4FLKA

Human metap1 with bengamide analog y10, in mn form
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 98
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4flkA00
4U1BA 2BH3A 4FLKA 4U76A 1C23A 3MR1A 2P9AA 1XGSA 2B3LA 1B59A 1JAWA 2GG8A 2GGCA 1O0XA 1XGNA 2B3KA 2G6PA 4IDYA 4U6WA 2BWWA 2BWUA 2BHDA 1YW8A 1PV9A 2BWTA 2MATA 2P99A 4KM3A 2HOWA 2BB7A 3IU9A 4FKCA 4U6CA 2EA4A 4FLJA 1Y1NA 4U6EA 2EVCA 4B28A 5CDEA 1C22A 2Q93A 4QR8A 4U73A 1QXWA 2GA2A 1CHMA 2BHBA 2GG2A 4RZYA 2Q92A 1WL6A 5CE6A 5CIKA 3BITA 3BIPA 3IG4A 2Q94A 1YW9A 3L24A 5JI6A 1C21A 2GG5A 5FCFA 5E5BA 1R58A 2GG7A 2NQ7A 1BN5A 4FLLA 5CNXA 4ZWUA 3D27A 2ZSGA 4Z7MA 3FMQA 4A6WA 4A6VA 3PKAA 1M35A 2BWSA 4IKSA 2V6CA 4ZNGA 2DFIA 3CB5A 4S2RP 4HXXA 3PKBA 3BIQA 1WL9A 4FUKA 5JHUA 3L7GA 1W2MA 4IKTA 1WN1A 5D6EA 5CDVA 1MATA 2OAZA 3IU8A 4IKUA 3RVAA 3TB5A 2GU5A 3MX6A 4IKRA 3FM3A 2Q8KA 3CB6A 4RGZ1 2GU7A 4U69A 4S2TP 1C27A 1KQ0A 2GG0A 2GU6A 3MATA 3Q6DA 3TAVA 2BWYA 1XGMA 2Q96A 2ADUA 4FLIA 4IF7A 1XGOA 2GG9A 3S6BA 4U75A 1R5GA 1QZYA 2GU4A 2EVOA 2EA2A 2NQ6A 1WKMA 5CLSA 2BHCA 4PV4A 1R5HA 2P98A 4IPAA 4U70A 4JUQA 3RORA 2GG3A 4R60A 4OOKA 4U6JA 1YJ3A 2OKNA 4EGEA 2GGBA 3FMRA 1WBQA 2V3ZA 1YW7A 2GZ5A 2BWVA 4S01A 1B6AA 5JFRA 3IU7A 1XNZA 4U6ZA 4MATA 1WLRA 4ZWOA 1YVMA 2V3XA 1QXZA 3CTZA 1BOAA 4IU6A 4S00A 5CDLA 3PKDA 1A16A 2GTXA 5D6FA 1W7VA 1WY2A 3PKCA 4U71A 1QXYA 4ZWPA 2IW2A 2Q95A 1KQ9A 5FCHA 4RZZA 2EVMA 4IECA 2B3HA 1KP0A 2BHAA 3PKEA 2V3YA 4FO8A 1C24A 4FO7A 4PNCA 1N51A 2BWXA 2BN7A
chains in the Genus database with same CATH superfamily
4U1BA 2BH3A 4FLKA 4U76A 1C23A 3MR1A 2P9AA 1XGSA 2B3LA 1B59A 1JAWA 2GG8A 2GGCA 1O0XA 1XGNA 2B3KA 2G6PA 4IDYA 4U6WA 2BWWA 2BWUA 2BHDA 1YW8A 1PV9A 2BWTA 2MATA 2P99A 4KM3A 2HOWA 2BB7A 3IU9A 4FKCA 4U6CA 2EA4A 4FLJA 1Y1NA 4U6EA 2EVCA 4B28A 5CDEA 1C22A 2Q93A 4QR8A 4U73A 1QXWA 2GA2A 1CHMA 2BHBA 2GG2A 4RZYA 2Q92A 1WL6A 5CE6A 5CIKA 3BITA 3BIPA 3IG4A 2Q94A 1YW9A 3L24A 5JI6A 1C21A 2GG5A 5FCFA 5E5BA 1R58A 2GG7A 2NQ7A 1BN5A 4FLLA 5CNXA 4ZWUA 3D27A 2ZSGA 4Z7MA 3FMQA 4A6WA 4A6VA 3PKAA 1M35A 2BWSA 4IKSA 2V6CA 4ZNGA 2DFIA 3CB5A 4S2RP 4HXXA 3PKBA 3BIQA 1WL9A 4FUKA 5JHUA 3L7GA 1W2MA 4IKTA 1WN1A 5D6EA 5CDVA 1MATA 2OAZA 3IU8A 4IKUA 3RVAA 3TB5A 2GU5A 3MX6A 4IKRA 3FM3A 2Q8KA 3CB6A 4RGZ1 2GU7A 4U69A 4S2TP 1C27A 1KQ0A 2GG0A 2GU6A 3MATA 3Q6DA 3TAVA 2BWYA 1XGMA 2Q96A 2ADUA 4FLIA 4IF7A 1XGOA 2GG9A 3S6BA 4U75A 1R5GA 1QZYA 2GU4A 2EVOA 2EA2A 2NQ6A 1WKMA 5CLSA 2BHCA 4PV4A 1R5HA 2P98A 4IPAA 4U70A 4JUQA 3RORA 2GG3A 4R60A 4OOKA 4U6JA 1YJ3A 2OKNA 4EGEA 2GGBA 3FMRA 1WBQA 2V3ZA 1YW7A 2GZ5A 2BWVA 4S01A 1B6AA 5JFRA 3IU7A 1XNZA 4U6ZA 4MATA 1WLRA 4ZWOA 1YVMA 2V3XA 1QXZA 3CTZA 1BOAA 4IU6A 4S00A 5CDLA 3PKDA 1A16A 2GTXA 5D6FA 1W7VA 1WY2A 3PKCA 4U71A 1QXYA 4ZWPA 2IW2A 2Q95A 1KQ9A 5FCHA 4RZZA 2EVMA 4IECA 2B3HA 1KP0A 2BHAA 3PKEA 2V3YA 4FO8A 1C24A 4FO7A 4PNCA 1N51A 2BWXA 2BN7A
chains in the Genus database with same CATH topology
4U1BA 2BH3A 4FLKA 4U76A 1C23A 3MR1A 2P9AA 1XGSA 2B3LA 1B59A 1JAWA 2GG8A 2GGCA 1O0XA 1XGNA 2B3KA 2G6PA 4IDYA 4U6WA 2BWWA 2BWUA 2BHDA 1YW8A 1PV9A 2BWTA 2MATA 2P99A 4KM3A 2HOWA 2BB7A 3IU9A 4FKCA 4U6CA 2EA4A 4FLJA 1Y1NA 4U6EA 2EVCA 4B28A 5CDEA 1C22A 2Q93A 4QR8A 4U73A 1QXWA 2GA2A 1CHMA 2BHBA 2GG2A 4RZYA 2Q92A 1WL6A 5CE6A 5CIKA 3BITA 3BIPA 3IG4A 2Q94A 1YW9A 3L24A 5JI6A 1C21A 2GG5A 5FCFA 5E5BA 1R58A 2GG7A 2NQ7A 1BN5A 4FLLA 5CNXA 4ZWUA 3D27A 2ZSGA 4Z7MA 3FMQA 4A6WA 4A6VA 3PKAA 1M35A 2BWSA 4IKSA 2V6CA 4ZNGA 2DFIA 3CB5A 4S2RP 4HXXA 3PKBA 3BIQA 1WL9A 4FUKA 5JHUA 3L7GA 1W2MA 4IKTA 1WN1A 5D6EA 5CDVA 1MATA 2OAZA 3IU8A 4IKUA 3RVAA 3TB5A 2GU5A 3MX6A 4IKRA 3FM3A 2Q8KA 3CB6A 4RGZ1 2GU7A 4U69A 4S2TP 1C27A 1KQ0A 2GG0A 2GU6A 3MATA 3Q6DA 3TAVA 2BWYA 1XGMA 2Q96A 2ADUA 4FLIA 4IF7A 1XGOA 2GG9A 3S6BA 4U75A 1R5GA 1QZYA 2GU4A 2EVOA 2EA2A 2NQ6A 1WKMA 5CLSA 2BHCA 4PV4A 1R5HA 2P98A 4IPAA 4U70A 4JUQA 3RORA 2GG3A 4R60A 4OOKA 4U6JA 1YJ3A 2OKNA 4EGEA 2GGBA 3FMRA 1WBQA 2V3ZA 1YW7A 2GZ5A 2BWVA 4S01A 1B6AA 5JFRA 3IU7A 1XNZA 4U6ZA 4MATA 1WLRA 4ZWOA 1YVMA 2V3XA 1QXZA 3CTZA 1BOAA 4IU6A 4S00A 5CDLA 3PKDA 1A16A 2GTXA 5D6FA 1W7VA 1WY2A 3PKCA 4U71A 1QXYA 4ZWPA 2IW2A 2Q95A 1KQ9A 5FCHA 4RZZA 2EVMA 4IECA 2B3HA 1KP0A 2BHAA 3PKEA 2V3YA 4FO8A 1C24A 4FO7A 4PNCA 1N51A 2BWXA 2BN7A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4U1B A;  2BH3 A;  4FLK A;  4U76 A;  1C23 A;  3MR1 A;  2P9A A;  1XGS A;  2B3L A;  1B59 A;  1JAW A;  2GG8 A;  2GGC A;  1O0X A;  1XGN A;  2B3K A;  2G6P A;  4IDY A;  4U6W A;  2BWW A;  2BWU A;  2BHD A;  1YW8 A;  1PV9 A;  2BWT A;  2MAT A;  2P99 A;  4KM3 A;  2HOW A;  2BB7 A;  3IU9 A;  4FKC A;  4U6C A;  2EA4 A;  4FLJ A;  1Y1N A;  4U6E A;  2EVC A;  4B28 A;  5CDE A;  1C22 A;  2Q93 A;  4QR8 A;  4U73 A;  1QXW A;  2GA2 A;  1CHM A;  2BHB A;  2GG2 A;  4RZY A;  2Q92 A;  1WL6 A;  5CE6 A;  5CIK A;  3BIT A;  3BIP A;  3IG4 A;  2Q94 A;  1YW9 A;  3L24 A;  5JI6 A;  1C21 A;  2GG5 A;  5FCF A;  5E5B A;  1R58 A;  2GG7 A;  2NQ7 A;  1BN5 A;  4FLL A;  5CNX A;  4ZWU A;  3D27 A;  2ZSG A;  4Z7M A;  3FMQ A;  4A6W A;  4A6V A;  3PKA A;  1M35 A;  2BWS A;  4IKS A;  2V6C A;  4ZNG A;  2DFI A;  3CB5 A;  4S2R P;  4HXX A;  3PKB A;  3BIQ A;  1WL9 A;  4FUK A;  5JHU A;  3L7G A;  1W2M A;  4IKT A;  1WN1 A;  5D6E A;  5CDV A;  1MAT A;  2OAZ A;  3IU8 A;  4IKU A;  3RVA A;  3TB5 A;  2GU5 A;  3MX6 A;  4IKR A;  3FM3 A;  2Q8K A;  3CB6 A;  4RGZ 1;  2GU7 A;  4U69 A;  4S2T P;  1C27 A;  1KQ0 A;  2GG0 A;  2GU6 A;  3MAT A;  3Q6D A;  3TAV A;  2BWY A;  1XGM A;  2Q96 A;  2ADU A;  4FLI A;  4IF7 A;  1XGO A;  2GG9 A;  3S6B A;  4U75 A;  1R5G A;  1QZY A;  2GU4 A;  2EVO A;  2EA2 A;  2NQ6 A;  1WKM A;  5CLS A;  2BHC A;  4PV4 A;  1R5H A;  2P98 A;  4IPA A;  4U70 A;  4JUQ A;  3ROR A;  2GG3 A;  4R60 A;  4OOK A;  4U6J A;  1YJ3 A;  2OKN A;  4EGE A;  2GGB A;  3FMR A;  1WBQ A;  2V3Z A;  1YW7 A;  2GZ5 A;  2BWV A;  4S01 A;  1B6A A;  5JFR A;  3IU7 A;  1XNZ A;  4U6Z A;  4MAT A;  1WLR A;  4ZWO A;  1YVM A;  2V3X A;  1QXZ A;  3CTZ A;  1BOA A;  4IU6 A;  4S00 A;  5CDL A;  3PKD A;  1A16 A;  2GTX A;  5D6F A;  1W7V A;  1WY2 A;  3PKC A;  4U71 A;  1QXY A;  4ZWP A;  2IW2 A;  2Q95 A;  1KQ9 A;  5FCH A;  4RZZ A;  2EVM A;  4IEC A;  2B3H A;  1KP0 A;  2BHA A;  3PKE A;  2V3Y A;  4FO8 A;  1C24 A;  4FO7 A;  4PNC A;  1N51 A;  2BWX A;  2BN7 A; 
#chains in the Genus database with same CATH topology
 4U1B A;  2BH3 A;  4FLK A;  4U76 A;  1C23 A;  3MR1 A;  2P9A A;  1XGS A;  2B3L A;  1B59 A;  1JAW A;  2GG8 A;  2GGC A;  1O0X A;  1XGN A;  2B3K A;  2G6P A;  4IDY A;  4U6W A;  2BWW A;  2BWU A;  2BHD A;  1YW8 A;  1PV9 A;  2BWT A;  2MAT A;  2P99 A;  4KM3 A;  2HOW A;  2BB7 A;  3IU9 A;  4FKC A;  4U6C A;  2EA4 A;  4FLJ A;  1Y1N A;  4U6E A;  2EVC A;  4B28 A;  5CDE A;  1C22 A;  2Q93 A;  4QR8 A;  4U73 A;  1QXW A;  2GA2 A;  1CHM A;  2BHB A;  2GG2 A;  4RZY A;  2Q92 A;  1WL6 A;  5CE6 A;  5CIK A;  3BIT A;  3BIP A;  3IG4 A;  2Q94 A;  1YW9 A;  3L24 A;  5JI6 A;  1C21 A;  2GG5 A;  5FCF A;  5E5B A;  1R58 A;  2GG7 A;  2NQ7 A;  1BN5 A;  4FLL A;  5CNX A;  4ZWU A;  3D27 A;  2ZSG A;  4Z7M A;  3FMQ A;  4A6W A;  4A6V A;  3PKA A;  1M35 A;  2BWS A;  4IKS A;  2V6C A;  4ZNG A;  2DFI A;  3CB5 A;  4S2R P;  4HXX A;  3PKB A;  3BIQ A;  1WL9 A;  4FUK A;  5JHU A;  3L7G A;  1W2M A;  4IKT A;  1WN1 A;  5D6E A;  5CDV A;  1MAT A;  2OAZ A;  3IU8 A;  4IKU A;  3RVA A;  3TB5 A;  2GU5 A;  3MX6 A;  4IKR A;  3FM3 A;  2Q8K A;  3CB6 A;  4RGZ 1;  2GU7 A;  4U69 A;  4S2T P;  1C27 A;  1KQ0 A;  2GG0 A;  2GU6 A;  3MAT A;  3Q6D A;  3TAV A;  2BWY A;  1XGM A;  2Q96 A;  2ADU A;  4FLI A;  4IF7 A;  1XGO A;  2GG9 A;  3S6B A;  4U75 A;  1R5G A;  1QZY A;  2GU4 A;  2EVO A;  2EA2 A;  2NQ6 A;  1WKM A;  5CLS A;  2BHC A;  4PV4 A;  1R5H A;  2P98 A;  4IPA A;  4U70 A;  4JUQ A;  3ROR A;  2GG3 A;  4R60 A;  4OOK A;  4U6J A;  1YJ3 A;  2OKN A;  4EGE A;  2GGB A;  3FMR A;  1WBQ A;  2V3Z A;  1YW7 A;  2GZ5 A;  2BWV A;  4S01 A;  1B6A A;  5JFR A;  3IU7 A;  1XNZ A;  4U6Z A;  4MAT A;  1WLR A;  4ZWO A;  1YVM A;  2V3X A;  1QXZ A;  3CTZ A;  1BOA A;  4IU6 A;  4S00 A;  5CDL A;  3PKD A;  1A16 A;  2GTX A;  5D6F A;  1W7V A;  1WY2 A;  3PKC A;  4U71 A;  1QXY A;  4ZWP A;  2IW2 A;  2Q95 A;  1KQ9 A;  5FCH A;  4RZZ A;  2EVM A;  4IEC A;  2B3H A;  1KP0 A;  2BHA A;  3PKE A;  2V3Y A;  4FO8 A;  1C24 A;  4FO7 A;  4PNC A;  1N51 A;  2BWX A;  2BN7 A; 
#chains in the Genus database with same CATH homology
 4U1B A;  2BH3 A;  4FLK A;  4U76 A;  1C23 A;  3MR1 A;  2P9A A;  1XGS A;  2B3L A;  1B59 A;  1JAW A;  2GG8 A;  2GGC A;  1O0X A;  1XGN A;  2B3K A;  2G6P A;  4IDY A;  4U6W A;  2BWW A;  2BWU A;  2BHD A;  1YW8 A;  1PV9 A;  2BWT A;  2MAT A;  2P99 A;  4KM3 A;  2HOW A;  2BB7 A;  3IU9 A;  4FKC A;  4U6C A;  2EA4 A;  4FLJ A;  1Y1N A;  4U6E A;  2EVC A;  4B28 A;  5CDE A;  1C22 A;  2Q93 A;  4QR8 A;  4U73 A;  1QXW A;  2GA2 A;  1CHM A;  2BHB A;  2GG2 A;  4RZY A;  2Q92 A;  1WL6 A;  5CE6 A;  5CIK A;  3BIT A;  3BIP A;  3IG4 A;  2Q94 A;  1YW9 A;  3L24 A;  5JI6 A;  1C21 A;  2GG5 A;  5FCF A;  5E5B A;  1R58 A;  2GG7 A;  2NQ7 A;  1BN5 A;  4FLL A;  5CNX A;  4ZWU A;  3D27 A;  2ZSG A;  4Z7M A;  3FMQ A;  4A6W A;  4A6V A;  3PKA A;  1M35 A;  2BWS A;  4IKS A;  2V6C A;  4ZNG A;  2DFI A;  3CB5 A;  4S2R P;  4HXX A;  3PKB A;  3BIQ A;  1WL9 A;  4FUK A;  5JHU A;  3L7G A;  1W2M A;  4IKT A;  1WN1 A;  5D6E A;  5CDV A;  1MAT A;  2OAZ A;  3IU8 A;  4IKU A;  3RVA A;  3TB5 A;  2GU5 A;  3MX6 A;  4IKR A;  3FM3 A;  2Q8K A;  3CB6 A;  4RGZ 1;  2GU7 A;  4U69 A;  4S2T P;  1C27 A;  1KQ0 A;  2GG0 A;  2GU6 A;  3MAT A;  3Q6D A;  3TAV A;  2BWY A;  1XGM A;  2Q96 A;  2ADU A;  4FLI A;  4IF7 A;  1XGO A;  2GG9 A;  3S6B A;  4U75 A;  1R5G A;  1QZY A;  2GU4 A;  2EVO A;  2EA2 A;  2NQ6 A;  1WKM A;  5CLS A;  2BHC A;  4PV4 A;  1R5H A;  2P98 A;  4IPA A;  4U70 A;  4JUQ A;  3ROR A;  2GG3 A;  4R60 A;  4OOK A;  4U6J A;  1YJ3 A;  2OKN A;  4EGE A;  2GGB A;  3FMR A;  1WBQ A;  2V3Z A;  1YW7 A;  2GZ5 A;  2BWV A;  4S01 A;  1B6A A;  5JFR A;  3IU7 A;  1XNZ A;  4U6Z A;  4MAT A;  1WLR A;  4ZWO A;  1YVM A;  2V3X A;  1QXZ A;  3CTZ A;  1BOA A;  4IU6 A;  4S00 A;  5CDL A;  3PKD A;  1A16 A;  2GTX A;  5D6F A;  1W7V A;  1WY2 A;  3PKC A;  4U71 A;  1QXY A;  4ZWP A;  2IW2 A;  2Q95 A;  1KQ9 A;  5FCH A;  4RZZ A;  2EVM A;  4IEC A;  2B3H A;  1KP0 A;  2BHA A;  3PKE A;  2V3Y A;  4FO8 A;  1C24 A;  4FO7 A;  4PNC A;  1N51 A;  2BWX A;  2BN7 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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