2Q93A

E. coli methionine aminopeptidase mn-form with inhibitor b21
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli
publication title Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop flexibility in selective inhibition of bacterial enzymes.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 83
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-06-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2q93A00
1CHMA 1C22A 1WBQA 1YW7A 2EVMA 4S2RP 1C24A 1R5GA 2EA4A 2BWSA 4FLLA 4IECA 2V3XA 1WL6A 3IG4A 2OKNA 1KQ9A 1YVMA 2BWUA 2BWWA 4IDYA 4IKUA 5JI6A 5D6EA 1QXZA 3D27A 4B28A 2GG8A 2BHDA 3PKAA 2Q8KA 4U76A 4ZWPA 1WLRA 2GA2A 4MATA 2EA2A 1N51A 1WL9A 3RORA 4OOKA 3CB6A 2BWTA 2P9AA 5CDVA 3MX6A 5CE6A 1WKMA 2GU4A 4IKSA 1W2MA 3IU8A 1XGMA 3FM3A 4U70A 2EVCA 2ZSGA 4IKTA 1BN5A 1A16A 1W7VA 2Q94A 1WY2A 3FMQA 5CLSA 4ZWUA 2OAZA 2DFIA 2GGBA 4FO8A 4QR8A 4S00A 3Q6DA 1C21A 4Z7MA 3TB5A 5FCFA 5CIKA 1XGNA 4U71A 3CTZA 2BWYA 1O0XA 5CNXA 1R58A 2IW2A 2B3KA 1KQ0A 1C23A 2BHBA 4FUKA 2V6CA 2B3HA 3S6BA 5CDEA 2MATA 3L24A 3RVAA 2BH3A 1QZYA 4RZYA 4ZWOA 4RGZ1 4PV4A 2Q96A 2B3LA 2GG0A 1QXWA 2GU7A 2P98A 4JUQA 3MR1A 5CDLA 2Q92A 2GG9A 3IU9A 2GGCA 4FLKA 3TAVA 4IU6A 2GG7A 3PKDA 4ZNGA 4A6VA 1YW8A 3IU7A 3BIQA 2Q95A 4U6EA 3PKBA 3CB5A 3PKEA 1QXYA 1R5HA 2BN7A 4FKCA 2HOWA 2BWVA 4S01A 1C27A 4IPAA 4R60A 4IKRA 2V3ZA 5FCHA 1MATA 3FMRA 1BOAA 1JAWA 2GG5A 5JFRA 1YW9A 4FLIA 4U73A 3BITA 4U69A 4S2TP 5JHUA 3PKCA 4RZZA 3BIPA 2ADUA 2BB7A 4A6WA 3MATA 1Y1NA 1PV9A 2GU6A 2P99A 1WN1A 2BWXA 4U6ZA 2V3YA 4U1BA 4HXXA 4FO7A 5D6FA 1XGSA 2NQ7A 1B59A 4PNCA 1YJ3A 2Q93A 4U6WA 3L7GA 4U75A 5E5BA 2EVOA 4U6JA 2GG2A 2NQ6A 2GG3A 1B6AA 1XNZA 4FLJA 2BHCA 4KM3A 2GZ5A 2GTXA 4U6CA 1XGOA 4EGEA 4IF7A 2BHAA 2GU5A 1KP0A 2G6PA 1M35A
chains in the Genus database with same CATH superfamily
1CHMA 1C22A 1WBQA 1YW7A 2EVMA 4S2RP 1C24A 1R5GA 2EA4A 2BWSA 4FLLA 4IECA 2V3XA 1WL6A 3IG4A 2OKNA 1KQ9A 1YVMA 2BWUA 2BWWA 4IDYA 4IKUA 5JI6A 5D6EA 1QXZA 3D27A 4B28A 2GG8A 2BHDA 3PKAA 2Q8KA 4U76A 4ZWPA 1WLRA 2GA2A 4MATA 2EA2A 1N51A 1WL9A 3RORA 4OOKA 3CB6A 2BWTA 2P9AA 5CDVA 3MX6A 5CE6A 1WKMA 2GU4A 4IKSA 1W2MA 3IU8A 1XGMA 3FM3A 4U70A 2EVCA 2ZSGA 4IKTA 1BN5A 1A16A 1W7VA 2Q94A 1WY2A 3FMQA 5CLSA 4ZWUA 2OAZA 2DFIA 2GGBA 4FO8A 4QR8A 4S00A 3Q6DA 1C21A 4Z7MA 3TB5A 5FCFA 5CIKA 1XGNA 4U71A 3CTZA 2BWYA 1O0XA 5CNXA 1R58A 2IW2A 2B3KA 1KQ0A 1C23A 2BHBA 4FUKA 2V6CA 2B3HA 3S6BA 5CDEA 2MATA 3L24A 3RVAA 2BH3A 1QZYA 4RZYA 4ZWOA 4RGZ1 4PV4A 2Q96A 2B3LA 2GG0A 1QXWA 2GU7A 2P98A 4JUQA 3MR1A 5CDLA 2Q92A 2GG9A 3IU9A 2GGCA 4FLKA 3TAVA 4IU6A 2GG7A 3PKDA 4ZNGA 4A6VA 1YW8A 3IU7A 3BIQA 2Q95A 4U6EA 3PKBA 3CB5A 3PKEA 1QXYA 1R5HA 2BN7A 4FKCA 2HOWA 2BWVA 4S01A 1C27A 4IPAA 4R60A 4IKRA 2V3ZA 5FCHA 1MATA 3FMRA 1BOAA 1JAWA 2GG5A 5JFRA 1YW9A 4FLIA 4U73A 3BITA 4U69A 4S2TP 5JHUA 3PKCA 4RZZA 3BIPA 2ADUA 2BB7A 4A6WA 3MATA 1Y1NA 1PV9A 2GU6A 2P99A 1WN1A 2BWXA 4U6ZA 2V3YA 4U1BA 4HXXA 4FO7A 5D6FA 1XGSA 2NQ7A 1B59A 4PNCA 1YJ3A 2Q93A 4U6WA 3L7GA 4U75A 5E5BA 2EVOA 4U6JA 2GG2A 2NQ6A 2GG3A 1B6AA 1XNZA 4FLJA 2BHCA 4KM3A 2GZ5A 2GTXA 4U6CA 1XGOA 4EGEA 4IF7A 2BHAA 2GU5A 1KP0A 2G6PA 1M35A
chains in the Genus database with same CATH topology
1CHMA 1C22A 1WBQA 1YW7A 2EVMA 4S2RP 1C24A 1R5GA 2EA4A 2BWSA 4FLLA 4IECA 2V3XA 1WL6A 3IG4A 2OKNA 1KQ9A 1YVMA 2BWUA 2BWWA 4IDYA 4IKUA 5JI6A 5D6EA 1QXZA 3D27A 4B28A 2GG8A 2BHDA 3PKAA 2Q8KA 4U76A 4ZWPA 1WLRA 2GA2A 4MATA 2EA2A 1N51A 1WL9A 3RORA 4OOKA 3CB6A 2BWTA 2P9AA 5CDVA 3MX6A 5CE6A 1WKMA 2GU4A 4IKSA 1W2MA 3IU8A 1XGMA 3FM3A 4U70A 2EVCA 2ZSGA 4IKTA 1BN5A 1A16A 1W7VA 2Q94A 1WY2A 3FMQA 5CLSA 4ZWUA 2OAZA 2DFIA 2GGBA 4FO8A 4QR8A 4S00A 3Q6DA 1C21A 4Z7MA 3TB5A 5FCFA 5CIKA 1XGNA 4U71A 3CTZA 2BWYA 1O0XA 5CNXA 1R58A 2IW2A 2B3KA 1KQ0A 1C23A 2BHBA 4FUKA 2V6CA 2B3HA 3S6BA 5CDEA 2MATA 3L24A 3RVAA 2BH3A 1QZYA 4RZYA 4ZWOA 4RGZ1 4PV4A 2Q96A 2B3LA 2GG0A 1QXWA 2GU7A 2P98A 4JUQA 3MR1A 5CDLA 2Q92A 2GG9A 3IU9A 2GGCA 4FLKA 3TAVA 4IU6A 2GG7A 3PKDA 4ZNGA 4A6VA 1YW8A 3IU7A 3BIQA 2Q95A 4U6EA 3PKBA 3CB5A 3PKEA 1QXYA 1R5HA 2BN7A 4FKCA 2HOWA 2BWVA 4S01A 1C27A 4IPAA 4R60A 4IKRA 2V3ZA 5FCHA 1MATA 3FMRA 1BOAA 1JAWA 2GG5A 5JFRA 1YW9A 4FLIA 4U73A 3BITA 4U69A 4S2TP 5JHUA 3PKCA 4RZZA 3BIPA 2ADUA 2BB7A 4A6WA 3MATA 1Y1NA 1PV9A 2GU6A 2P99A 1WN1A 2BWXA 4U6ZA 2V3YA 4U1BA 4HXXA 4FO7A 5D6FA 1XGSA 2NQ7A 1B59A 4PNCA 1YJ3A 2Q93A 4U6WA 3L7GA 4U75A 5E5BA 2EVOA 4U6JA 2GG2A 2NQ6A 2GG3A 1B6AA 1XNZA 4FLJA 2BHCA 4KM3A 2GZ5A 2GTXA 4U6CA 1XGOA 4EGEA 4IF7A 2BHAA 2GU5A 1KP0A 2G6PA 1M35A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1CHM A;  1C22 A;  1WBQ A;  1YW7 A;  2EVM A;  4S2R P;  1C24 A;  1R5G A;  2EA4 A;  2BWS A;  4FLL A;  4IEC A;  2V3X A;  1WL6 A;  3IG4 A;  2OKN A;  1KQ9 A;  1YVM A;  2BWU A;  2BWW A;  4IDY A;  4IKU A;  5JI6 A;  5D6E A;  1QXZ A;  3D27 A;  4B28 A;  2GG8 A;  2BHD A;  3PKA A;  2Q8K A;  4U76 A;  4ZWP A;  1WLR A;  2GA2 A;  4MAT A;  2EA2 A;  1N51 A;  1WL9 A;  3ROR A;  4OOK A;  3CB6 A;  2BWT A;  2P9A A;  5CDV A;  3MX6 A;  5CE6 A;  1WKM A;  2GU4 A;  4IKS A;  1W2M A;  3IU8 A;  1XGM A;  3FM3 A;  4U70 A;  2EVC A;  2ZSG A;  4IKT A;  1BN5 A;  1A16 A;  1W7V A;  2Q94 A;  1WY2 A;  3FMQ A;  5CLS A;  4ZWU A;  2OAZ A;  2DFI A;  2GGB A;  4FO8 A;  4QR8 A;  4S00 A;  3Q6D A;  1C21 A;  4Z7M A;  3TB5 A;  5FCF A;  5CIK A;  1XGN A;  4U71 A;  3CTZ A;  2BWY A;  1O0X A;  5CNX A;  1R58 A;  2IW2 A;  2B3K A;  1KQ0 A;  1C23 A;  2BHB A;  4FUK A;  2V6C A;  2B3H A;  3S6B A;  5CDE A;  2MAT A;  3L24 A;  3RVA A;  2BH3 A;  1QZY A;  4RZY A;  4ZWO A;  4RGZ 1;  4PV4 A;  2Q96 A;  2B3L A;  2GG0 A;  1QXW A;  2GU7 A;  2P98 A;  4JUQ A;  3MR1 A;  5CDL A;  2Q92 A;  2GG9 A;  3IU9 A;  2GGC A;  4FLK A;  3TAV A;  4IU6 A;  2GG7 A;  3PKD A;  4ZNG A;  4A6V A;  1YW8 A;  3IU7 A;  3BIQ A;  2Q95 A;  4U6E A;  3PKB A;  3CB5 A;  3PKE A;  1QXY A;  1R5H A;  2BN7 A;  4FKC A;  2HOW A;  2BWV A;  4S01 A;  1C27 A;  4IPA A;  4R60 A;  4IKR A;  2V3Z A;  5FCH A;  1MAT A;  3FMR A;  1BOA A;  1JAW A;  2GG5 A;  5JFR A;  1YW9 A;  4FLI A;  4U73 A;  3BIT A;  4U69 A;  4S2T P;  5JHU A;  3PKC A;  4RZZ A;  3BIP A;  2ADU A;  2BB7 A;  4A6W A;  3MAT A;  1Y1N A;  1PV9 A;  2GU6 A;  2P99 A;  1WN1 A;  2BWX A;  4U6Z A;  2V3Y A;  4U1B A;  4HXX A;  4FO7 A;  5D6F A;  1XGS A;  2NQ7 A;  1B59 A;  4PNC A;  1YJ3 A;  2Q93 A;  4U6W A;  3L7G A;  4U75 A;  5E5B A;  2EVO A;  4U6J A;  2GG2 A;  2NQ6 A;  2GG3 A;  1B6A A;  1XNZ A;  4FLJ A;  2BHC A;  4KM3 A;  2GZ5 A;  2GTX A;  4U6C A;  1XGO A;  4EGE A;  4IF7 A;  2BHA A;  2GU5 A;  1KP0 A;  2G6P A;  1M35 A; 
#chains in the Genus database with same CATH topology
 1CHM A;  1C22 A;  1WBQ A;  1YW7 A;  2EVM A;  4S2R P;  1C24 A;  1R5G A;  2EA4 A;  2BWS A;  4FLL A;  4IEC A;  2V3X A;  1WL6 A;  3IG4 A;  2OKN A;  1KQ9 A;  1YVM A;  2BWU A;  2BWW A;  4IDY A;  4IKU A;  5JI6 A;  5D6E A;  1QXZ A;  3D27 A;  4B28 A;  2GG8 A;  2BHD A;  3PKA A;  2Q8K A;  4U76 A;  4ZWP A;  1WLR A;  2GA2 A;  4MAT A;  2EA2 A;  1N51 A;  1WL9 A;  3ROR A;  4OOK A;  3CB6 A;  2BWT A;  2P9A A;  5CDV A;  3MX6 A;  5CE6 A;  1WKM A;  2GU4 A;  4IKS A;  1W2M A;  3IU8 A;  1XGM A;  3FM3 A;  4U70 A;  2EVC A;  2ZSG A;  4IKT A;  1BN5 A;  1A16 A;  1W7V A;  2Q94 A;  1WY2 A;  3FMQ A;  5CLS A;  4ZWU A;  2OAZ A;  2DFI A;  2GGB A;  4FO8 A;  4QR8 A;  4S00 A;  3Q6D A;  1C21 A;  4Z7M A;  3TB5 A;  5FCF A;  5CIK A;  1XGN A;  4U71 A;  3CTZ A;  2BWY A;  1O0X A;  5CNX A;  1R58 A;  2IW2 A;  2B3K A;  1KQ0 A;  1C23 A;  2BHB A;  4FUK A;  2V6C A;  2B3H A;  3S6B A;  5CDE A;  2MAT A;  3L24 A;  3RVA A;  2BH3 A;  1QZY A;  4RZY A;  4ZWO A;  4RGZ 1;  4PV4 A;  2Q96 A;  2B3L A;  2GG0 A;  1QXW A;  2GU7 A;  2P98 A;  4JUQ A;  3MR1 A;  5CDL A;  2Q92 A;  2GG9 A;  3IU9 A;  2GGC A;  4FLK A;  3TAV A;  4IU6 A;  2GG7 A;  3PKD A;  4ZNG A;  4A6V A;  1YW8 A;  3IU7 A;  3BIQ A;  2Q95 A;  4U6E A;  3PKB A;  3CB5 A;  3PKE A;  1QXY A;  1R5H A;  2BN7 A;  4FKC A;  2HOW A;  2BWV A;  4S01 A;  1C27 A;  4IPA A;  4R60 A;  4IKR A;  2V3Z A;  5FCH A;  1MAT A;  3FMR A;  1BOA A;  1JAW A;  2GG5 A;  5JFR A;  1YW9 A;  4FLI A;  4U73 A;  3BIT A;  4U69 A;  4S2T P;  5JHU A;  3PKC A;  4RZZ A;  3BIP A;  2ADU A;  2BB7 A;  4A6W A;  3MAT A;  1Y1N A;  1PV9 A;  2GU6 A;  2P99 A;  1WN1 A;  2BWX A;  4U6Z A;  2V3Y A;  4U1B A;  4HXX A;  4FO7 A;  5D6F A;  1XGS A;  2NQ7 A;  1B59 A;  4PNC A;  1YJ3 A;  2Q93 A;  4U6W A;  3L7G A;  4U75 A;  5E5B A;  2EVO A;  4U6J A;  2GG2 A;  2NQ6 A;  2GG3 A;  1B6A A;  1XNZ A;  4FLJ A;  2BHC A;  4KM3 A;  2GZ5 A;  2GTX A;  4U6C A;  1XGO A;  4EGE A;  4IF7 A;  2BHA A;  2GU5 A;  1KP0 A;  2G6P A;  1M35 A; 
#chains in the Genus database with same CATH homology
 1CHM A;  1C22 A;  1WBQ A;  1YW7 A;  2EVM A;  4S2R P;  1C24 A;  1R5G A;  2EA4 A;  2BWS A;  4FLL A;  4IEC A;  2V3X A;  1WL6 A;  3IG4 A;  2OKN A;  1KQ9 A;  1YVM A;  2BWU A;  2BWW A;  4IDY A;  4IKU A;  5JI6 A;  5D6E A;  1QXZ A;  3D27 A;  4B28 A;  2GG8 A;  2BHD A;  3PKA A;  2Q8K A;  4U76 A;  4ZWP A;  1WLR A;  2GA2 A;  4MAT A;  2EA2 A;  1N51 A;  1WL9 A;  3ROR A;  4OOK A;  3CB6 A;  2BWT A;  2P9A A;  5CDV A;  3MX6 A;  5CE6 A;  1WKM A;  2GU4 A;  4IKS A;  1W2M A;  3IU8 A;  1XGM A;  3FM3 A;  4U70 A;  2EVC A;  2ZSG A;  4IKT A;  1BN5 A;  1A16 A;  1W7V A;  2Q94 A;  1WY2 A;  3FMQ A;  5CLS A;  4ZWU A;  2OAZ A;  2DFI A;  2GGB A;  4FO8 A;  4QR8 A;  4S00 A;  3Q6D A;  1C21 A;  4Z7M A;  3TB5 A;  5FCF A;  5CIK A;  1XGN A;  4U71 A;  3CTZ A;  2BWY A;  1O0X A;  5CNX A;  1R58 A;  2IW2 A;  2B3K A;  1KQ0 A;  1C23 A;  2BHB A;  4FUK A;  2V6C A;  2B3H A;  3S6B A;  5CDE A;  2MAT A;  3L24 A;  3RVA A;  2BH3 A;  1QZY A;  4RZY A;  4ZWO A;  4RGZ 1;  4PV4 A;  2Q96 A;  2B3L A;  2GG0 A;  1QXW A;  2GU7 A;  2P98 A;  4JUQ A;  3MR1 A;  5CDL A;  2Q92 A;  2GG9 A;  3IU9 A;  2GGC A;  4FLK A;  3TAV A;  4IU6 A;  2GG7 A;  3PKD A;  4ZNG A;  4A6V A;  1YW8 A;  3IU7 A;  3BIQ A;  2Q95 A;  4U6E A;  3PKB A;  3CB5 A;  3PKE A;  1QXY A;  1R5H A;  2BN7 A;  4FKC A;  2HOW A;  2BWV A;  4S01 A;  1C27 A;  4IPA A;  4R60 A;  4IKR A;  2V3Z A;  5FCH A;  1MAT A;  3FMR A;  1BOA A;  1JAW A;  2GG5 A;  5JFR A;  1YW9 A;  4FLI A;  4U73 A;  3BIT A;  4U69 A;  4S2T P;  5JHU A;  3PKC A;  4RZZ A;  3BIP A;  2ADU A;  2BB7 A;  4A6W A;  3MAT A;  1Y1N A;  1PV9 A;  2GU6 A;  2P99 A;  1WN1 A;  2BWX A;  4U6Z A;  2V3Y A;  4U1B A;  4HXX A;  4FO7 A;  5D6F A;  1XGS A;  2NQ7 A;  1B59 A;  4PNC A;  1YJ3 A;  2Q93 A;  4U6W A;  3L7G A;  4U75 A;  5E5B A;  2EVO A;  4U6J A;  2GG2 A;  2NQ6 A;  2GG3 A;  1B6A A;  1XNZ A;  4FLJ A;  2BHC A;  4KM3 A;  2GZ5 A;  2GTX A;  4U6C A;  1XGO A;  4EGE A;  4IF7 A;  2BHA A;  2GU5 A;  1KP0 A;  2G6P A;  1M35 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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