4IDYA

Mycobacterium tuberculosis methionine aminopeptidase type 1c in complex with 2-hydroxyethyl disulfide
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
282
structure length
281
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
total genus 87
structure length 281
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4idyA01
1C21A 3PKEA 2GA2A 3BIQA 3FM3A 4RZZA 2NQ6A 1WY2A 2OAZA 5JHUA 1XNZA 2GG2A 2BHCA 2EA4A 3CB5A 5FCHA 4ZWOA 1KQ9A 4IDYA 3L24A 5CE6A 1B59A 2ZSGA 1JAWA 1XGOA 4JUQA 1MATA 4IKUA 3BITA 1KP0A 2BH3A 2BB7A 2BN7A 4IPAA 2EA2A 3CB6A 2GGCA 3RORA 4EGEA 4U6WA 3PKDA 4U76A 2BWUA 1WBQA 4FLJA 4IF7A 4ZWPA 4U71A 4ZNGA 2P99A 3Q6DA 4IECA 2P98A 4S2TP 4FLKA 2V3XA 2GTXA 3BIPA 4IKRA 4U6JA 2BWXA 5E5BA 4QR8A 2EVCA 4U1BA 2BWTA 2GZ5A 2BWVA 1QXWA 2G6PA 4B28A 2B3HA 1YW8A 2GG8A 1R5GA 1Y1NA 5CLSA 3FMQA 3MX6A 4R60A 1XGMA 4FLLA 3D27A 2BHBA 3MATA 4MATA 2BHDA 2DFIA 1QXYA 2GGBA 3PKBA 1W7VA 1C23A 4U75A 2Q8KA 1C24A 5CDVA 5CNXA 3TAVA 4FKCA 1R58A 1YW7A 2BWYA 2OKNA 4S01A 1C27A 1O0XA 4U6ZA 2GU4A 3IU8A 3RVAA 2GG5A 4U73A 3TB5A 4IKTA 4FO8A 4S00A 3L7GA 4ZWUA 5CDLA 1XGNA 2P9AA 4FO7A 4PV4A 2BHAA 2Q92A 1PV9A 2MATA 2B3LA 3MR1A 5CDEA 2Q94A 3S6BA 1W2MA 1XGSA 1QZYA 1C22A 4RGZ1 2Q96A 4U69A 3IU9A 1N51A 3FMRA 5FCFA 2GU5A 4IU6A 1WKMA 5D6EA 5D6FA 4FLIA 1A16A 2NQ7A 2V6CA 4S2RP 4IKSA 4KM3A 1YW9A 2GU6A 1BOAA 3IG4A 2IW2A 4U70A 1WLRA 2ADUA 4A6WA 2GG9A 5JI6A 2B3KA 1CHMA 1KQ0A 1WL6A 5CIKA 4Z7MA 4PNCA 2EVOA 4U6CA 1WN1A 3PKCA 2GG3A 2HOWA 1BN5A 1B6AA 1QXZA 1WL9A 1YJ3A 2GG0A 2Q93A 3CTZA 4HXXA 4U6EA 4FUKA 2V3ZA 3PKAA 2Q95A 2BWWA 5JFRA 4OOKA 1R5HA 2GG7A 2EVMA 3IU7A 4RZYA 2GU7A 2V3YA 4A6VA 2BWSA 1M35A 1YVMA
chains in the Genus database with same CATH superfamily
1C21A 3PKEA 2GA2A 3BIQA 3FM3A 4RZZA 2NQ6A 1WY2A 2OAZA 5JHUA 1XNZA 2GG2A 2BHCA 2EA4A 3CB5A 5FCHA 4ZWOA 1KQ9A 4IDYA 3L24A 5CE6A 1B59A 2ZSGA 1JAWA 1XGOA 4JUQA 1MATA 4IKUA 3BITA 1KP0A 2BH3A 2BB7A 2BN7A 4IPAA 2EA2A 3CB6A 2GGCA 3RORA 4EGEA 4U6WA 3PKDA 4U76A 2BWUA 1WBQA 4FLJA 4IF7A 4ZWPA 4U71A 4ZNGA 2P99A 3Q6DA 4IECA 2P98A 4S2TP 4FLKA 2V3XA 2GTXA 3BIPA 4IKRA 4U6JA 2BWXA 5E5BA 4QR8A 2EVCA 4U1BA 2BWTA 2GZ5A 2BWVA 1QXWA 2G6PA 4B28A 2B3HA 1YW8A 2GG8A 1R5GA 1Y1NA 5CLSA 3FMQA 3MX6A 4R60A 1XGMA 4FLLA 3D27A 2BHBA 3MATA 4MATA 2BHDA 2DFIA 1QXYA 2GGBA 3PKBA 1W7VA 1C23A 4U75A 2Q8KA 1C24A 5CDVA 5CNXA 3TAVA 4FKCA 1R58A 1YW7A 2BWYA 2OKNA 4S01A 1C27A 1O0XA 4U6ZA 2GU4A 3IU8A 3RVAA 2GG5A 4U73A 3TB5A 4IKTA 4FO8A 4S00A 3L7GA 4ZWUA 5CDLA 1XGNA 2P9AA 4FO7A 4PV4A 2BHAA 2Q92A 1PV9A 2MATA 2B3LA 3MR1A 5CDEA 2Q94A 3S6BA 1W2MA 1XGSA 1QZYA 1C22A 4RGZ1 2Q96A 4U69A 3IU9A 1N51A 3FMRA 5FCFA 2GU5A 4IU6A 1WKMA 5D6EA 5D6FA 4FLIA 1A16A 2NQ7A 2V6CA 4S2RP 4IKSA 4KM3A 1YW9A 2GU6A 1BOAA 3IG4A 2IW2A 4U70A 1WLRA 2ADUA 4A6WA 2GG9A 5JI6A 2B3KA 1CHMA 1KQ0A 1WL6A 5CIKA 4Z7MA 4PNCA 2EVOA 4U6CA 1WN1A 3PKCA 2GG3A 2HOWA 1BN5A 1B6AA 1QXZA 1WL9A 1YJ3A 2GG0A 2Q93A 3CTZA 4HXXA 4U6EA 4FUKA 2V3ZA 3PKAA 2Q95A 2BWWA 5JFRA 4OOKA 1R5HA 2GG7A 2EVMA 3IU7A 4RZYA 2GU7A 2V3YA 4A6VA 2BWSA 1M35A 1YVMA
chains in the Genus database with same CATH topology
1C21A 3PKEA 2GA2A 3BIQA 3FM3A 4RZZA 2NQ6A 1WY2A 2OAZA 5JHUA 1XNZA 2GG2A 2BHCA 2EA4A 3CB5A 5FCHA 4ZWOA 1KQ9A 4IDYA 3L24A 5CE6A 1B59A 2ZSGA 1JAWA 1XGOA 4JUQA 1MATA 4IKUA 3BITA 1KP0A 2BH3A 2BB7A 2BN7A 4IPAA 2EA2A 3CB6A 2GGCA 3RORA 4EGEA 4U6WA 3PKDA 4U76A 2BWUA 1WBQA 4FLJA 4IF7A 4ZWPA 4U71A 4ZNGA 2P99A 3Q6DA 4IECA 2P98A 4S2TP 4FLKA 2V3XA 2GTXA 3BIPA 4IKRA 4U6JA 2BWXA 5E5BA 4QR8A 2EVCA 4U1BA 2BWTA 2GZ5A 2BWVA 1QXWA 2G6PA 4B28A 2B3HA 1YW8A 2GG8A 1R5GA 1Y1NA 5CLSA 3FMQA 3MX6A 4R60A 1XGMA 4FLLA 3D27A 2BHBA 3MATA 4MATA 2BHDA 2DFIA 1QXYA 2GGBA 3PKBA 1W7VA 1C23A 4U75A 2Q8KA 1C24A 5CDVA 5CNXA 3TAVA 4FKCA 1R58A 1YW7A 2BWYA 2OKNA 4S01A 1C27A 1O0XA 4U6ZA 2GU4A 3IU8A 3RVAA 2GG5A 4U73A 3TB5A 4IKTA 4FO8A 4S00A 3L7GA 4ZWUA 5CDLA 1XGNA 2P9AA 4FO7A 4PV4A 2BHAA 2Q92A 1PV9A 2MATA 2B3LA 3MR1A 5CDEA 2Q94A 3S6BA 1W2MA 1XGSA 1QZYA 1C22A 4RGZ1 2Q96A 4U69A 3IU9A 1N51A 3FMRA 5FCFA 2GU5A 4IU6A 1WKMA 5D6EA 5D6FA 4FLIA 1A16A 2NQ7A 2V6CA 4S2RP 4IKSA 4KM3A 1YW9A 2GU6A 1BOAA 3IG4A 2IW2A 4U70A 1WLRA 2ADUA 4A6WA 2GG9A 5JI6A 2B3KA 1CHMA 1KQ0A 1WL6A 5CIKA 4Z7MA 4PNCA 2EVOA 4U6CA 1WN1A 3PKCA 2GG3A 2HOWA 1BN5A 1B6AA 1QXZA 1WL9A 1YJ3A 2GG0A 2Q93A 3CTZA 4HXXA 4U6EA 4FUKA 2V3ZA 3PKAA 2Q95A 2BWWA 5JFRA 4OOKA 1R5HA 2GG7A 2EVMA 3IU7A 4RZYA 2GU7A 2V3YA 4A6VA 2BWSA 1M35A 1YVMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C21 A;  3PKE A;  2GA2 A;  3BIQ A;  3FM3 A;  4RZZ A;  2NQ6 A;  1WY2 A;  2OAZ A;  5JHU A;  1XNZ A;  2GG2 A;  2BHC A;  2EA4 A;  3CB5 A;  5FCH A;  4ZWO A;  1KQ9 A;  4IDY A;  3L24 A;  5CE6 A;  1B59 A;  2ZSG A;  1JAW A;  1XGO A;  4JUQ A;  1MAT A;  4IKU A;  3BIT A;  1KP0 A;  2BH3 A;  2BB7 A;  2BN7 A;  4IPA A;  2EA2 A;  3CB6 A;  2GGC A;  3ROR A;  4EGE A;  4U6W A;  3PKD A;  4U76 A;  2BWU A;  1WBQ A;  4FLJ A;  4IF7 A;  4ZWP A;  4U71 A;  4ZNG A;  2P99 A;  3Q6D A;  4IEC A;  2P98 A;  4S2T P;  4FLK A;  2V3X A;  2GTX A;  3BIP A;  4IKR A;  4U6J A;  2BWX A;  5E5B A;  4QR8 A;  2EVC A;  4U1B A;  2BWT A;  2GZ5 A;  2BWV A;  1QXW A;  2G6P A;  4B28 A;  2B3H A;  1YW8 A;  2GG8 A;  1R5G A;  1Y1N A;  5CLS A;  3FMQ A;  3MX6 A;  4R60 A;  1XGM A;  4FLL A;  3D27 A;  2BHB A;  3MAT A;  4MAT A;  2BHD A;  2DFI A;  1QXY A;  2GGB A;  3PKB A;  1W7V A;  1C23 A;  4U75 A;  2Q8K A;  1C24 A;  5CDV A;  5CNX A;  3TAV A;  4FKC A;  1R58 A;  1YW7 A;  2BWY A;  2OKN A;  4S01 A;  1C27 A;  1O0X A;  4U6Z A;  2GU4 A;  3IU8 A;  3RVA A;  2GG5 A;  4U73 A;  3TB5 A;  4IKT A;  4FO8 A;  4S00 A;  3L7G A;  4ZWU A;  5CDL A;  1XGN A;  2P9A A;  4FO7 A;  4PV4 A;  2BHA A;  2Q92 A;  1PV9 A;  2MAT A;  2B3L A;  3MR1 A;  5CDE A;  2Q94 A;  3S6B A;  1W2M A;  1XGS A;  1QZY A;  1C22 A;  4RGZ 1;  2Q96 A;  4U69 A;  3IU9 A;  1N51 A;  3FMR A;  5FCF A;  2GU5 A;  4IU6 A;  1WKM A;  5D6E A;  5D6F A;  4FLI A;  1A16 A;  2NQ7 A;  2V6C A;  4S2R P;  4IKS A;  4KM3 A;  1YW9 A;  2GU6 A;  1BOA A;  3IG4 A;  2IW2 A;  4U70 A;  1WLR A;  2ADU A;  4A6W A;  2GG9 A;  5JI6 A;  2B3K A;  1CHM A;  1KQ0 A;  1WL6 A;  5CIK A;  4Z7M A;  4PNC A;  2EVO A;  4U6C A;  1WN1 A;  3PKC A;  2GG3 A;  2HOW A;  1BN5 A;  1B6A A;  1QXZ A;  1WL9 A;  1YJ3 A;  2GG0 A;  2Q93 A;  3CTZ A;  4HXX A;  4U6E A;  4FUK A;  2V3Z A;  3PKA A;  2Q95 A;  2BWW A;  5JFR A;  4OOK A;  1R5H A;  2GG7 A;  2EVM A;  3IU7 A;  4RZY A;  2GU7 A;  2V3Y A;  4A6V A;  2BWS A;  1M35 A;  1YVM A; 
#chains in the Genus database with same CATH topology
 1C21 A;  3PKE A;  2GA2 A;  3BIQ A;  3FM3 A;  4RZZ A;  2NQ6 A;  1WY2 A;  2OAZ A;  5JHU A;  1XNZ A;  2GG2 A;  2BHC A;  2EA4 A;  3CB5 A;  5FCH A;  4ZWO A;  1KQ9 A;  4IDY A;  3L24 A;  5CE6 A;  1B59 A;  2ZSG A;  1JAW A;  1XGO A;  4JUQ A;  1MAT A;  4IKU A;  3BIT A;  1KP0 A;  2BH3 A;  2BB7 A;  2BN7 A;  4IPA A;  2EA2 A;  3CB6 A;  2GGC A;  3ROR A;  4EGE A;  4U6W A;  3PKD A;  4U76 A;  2BWU A;  1WBQ A;  4FLJ A;  4IF7 A;  4ZWP A;  4U71 A;  4ZNG A;  2P99 A;  3Q6D A;  4IEC A;  2P98 A;  4S2T P;  4FLK A;  2V3X A;  2GTX A;  3BIP A;  4IKR A;  4U6J A;  2BWX A;  5E5B A;  4QR8 A;  2EVC A;  4U1B A;  2BWT A;  2GZ5 A;  2BWV A;  1QXW A;  2G6P A;  4B28 A;  2B3H A;  1YW8 A;  2GG8 A;  1R5G A;  1Y1N A;  5CLS A;  3FMQ A;  3MX6 A;  4R60 A;  1XGM A;  4FLL A;  3D27 A;  2BHB A;  3MAT A;  4MAT A;  2BHD A;  2DFI A;  1QXY A;  2GGB A;  3PKB A;  1W7V A;  1C23 A;  4U75 A;  2Q8K A;  1C24 A;  5CDV A;  5CNX A;  3TAV A;  4FKC A;  1R58 A;  1YW7 A;  2BWY A;  2OKN A;  4S01 A;  1C27 A;  1O0X A;  4U6Z A;  2GU4 A;  3IU8 A;  3RVA A;  2GG5 A;  4U73 A;  3TB5 A;  4IKT A;  4FO8 A;  4S00 A;  3L7G A;  4ZWU A;  5CDL A;  1XGN A;  2P9A A;  4FO7 A;  4PV4 A;  2BHA A;  2Q92 A;  1PV9 A;  2MAT A;  2B3L A;  3MR1 A;  5CDE A;  2Q94 A;  3S6B A;  1W2M A;  1XGS A;  1QZY A;  1C22 A;  4RGZ 1;  2Q96 A;  4U69 A;  3IU9 A;  1N51 A;  3FMR A;  5FCF A;  2GU5 A;  4IU6 A;  1WKM A;  5D6E A;  5D6F A;  4FLI A;  1A16 A;  2NQ7 A;  2V6C A;  4S2R P;  4IKS A;  4KM3 A;  1YW9 A;  2GU6 A;  1BOA A;  3IG4 A;  2IW2 A;  4U70 A;  1WLR A;  2ADU A;  4A6W A;  2GG9 A;  5JI6 A;  2B3K A;  1CHM A;  1KQ0 A;  1WL6 A;  5CIK A;  4Z7M A;  4PNC A;  2EVO A;  4U6C A;  1WN1 A;  3PKC A;  2GG3 A;  2HOW A;  1BN5 A;  1B6A A;  1QXZ A;  1WL9 A;  1YJ3 A;  2GG0 A;  2Q93 A;  3CTZ A;  4HXX A;  4U6E A;  4FUK A;  2V3Z A;  3PKA A;  2Q95 A;  2BWW A;  5JFR A;  4OOK A;  1R5H A;  2GG7 A;  2EVM A;  3IU7 A;  4RZY A;  2GU7 A;  2V3Y A;  4A6V A;  2BWS A;  1M35 A;  1YVM A; 
#chains in the Genus database with same CATH homology
 1C21 A;  3PKE A;  2GA2 A;  3BIQ A;  3FM3 A;  4RZZ A;  2NQ6 A;  1WY2 A;  2OAZ A;  5JHU A;  1XNZ A;  2GG2 A;  2BHC A;  2EA4 A;  3CB5 A;  5FCH A;  4ZWO A;  1KQ9 A;  4IDY A;  3L24 A;  5CE6 A;  1B59 A;  2ZSG A;  1JAW A;  1XGO A;  4JUQ A;  1MAT A;  4IKU A;  3BIT A;  1KP0 A;  2BH3 A;  2BB7 A;  2BN7 A;  4IPA A;  2EA2 A;  3CB6 A;  2GGC A;  3ROR A;  4EGE A;  4U6W A;  3PKD A;  4U76 A;  2BWU A;  1WBQ A;  4FLJ A;  4IF7 A;  4ZWP A;  4U71 A;  4ZNG A;  2P99 A;  3Q6D A;  4IEC A;  2P98 A;  4S2T P;  4FLK A;  2V3X A;  2GTX A;  3BIP A;  4IKR A;  4U6J A;  2BWX A;  5E5B A;  4QR8 A;  2EVC A;  4U1B A;  2BWT A;  2GZ5 A;  2BWV A;  1QXW A;  2G6P A;  4B28 A;  2B3H A;  1YW8 A;  2GG8 A;  1R5G A;  1Y1N A;  5CLS A;  3FMQ A;  3MX6 A;  4R60 A;  1XGM A;  4FLL A;  3D27 A;  2BHB A;  3MAT A;  4MAT A;  2BHD A;  2DFI A;  1QXY A;  2GGB A;  3PKB A;  1W7V A;  1C23 A;  4U75 A;  2Q8K A;  1C24 A;  5CDV A;  5CNX A;  3TAV A;  4FKC A;  1R58 A;  1YW7 A;  2BWY A;  2OKN A;  4S01 A;  1C27 A;  1O0X A;  4U6Z A;  2GU4 A;  3IU8 A;  3RVA A;  2GG5 A;  4U73 A;  3TB5 A;  4IKT A;  4FO8 A;  4S00 A;  3L7G A;  4ZWU A;  5CDL A;  1XGN A;  2P9A A;  4FO7 A;  4PV4 A;  2BHA A;  2Q92 A;  1PV9 A;  2MAT A;  2B3L A;  3MR1 A;  5CDE A;  2Q94 A;  3S6B A;  1W2M A;  1XGS A;  1QZY A;  1C22 A;  4RGZ 1;  2Q96 A;  4U69 A;  3IU9 A;  1N51 A;  3FMR A;  5FCF A;  2GU5 A;  4IU6 A;  1WKM A;  5D6E A;  5D6F A;  4FLI A;  1A16 A;  2NQ7 A;  2V6C A;  4S2R P;  4IKS A;  4KM3 A;  1YW9 A;  2GU6 A;  1BOA A;  3IG4 A;  2IW2 A;  4U70 A;  1WLR A;  2ADU A;  4A6W A;  2GG9 A;  5JI6 A;  2B3K A;  1CHM A;  1KQ0 A;  1WL6 A;  5CIK A;  4Z7M A;  4PNC A;  2EVO A;  4U6C A;  1WN1 A;  3PKC A;  2GG3 A;  2HOW A;  1BN5 A;  1B6A A;  1QXZ A;  1WL9 A;  1YJ3 A;  2GG0 A;  2Q93 A;  3CTZ A;  4HXX A;  4U6E A;  4FUK A;  2V3Z A;  3PKA A;  2Q95 A;  2BWW A;  5JFR A;  4OOK A;  1R5H A;  2GG7 A;  2EVM A;  3IU7 A;  4RZY A;  2GU7 A;  2V3Y A;  4A6V A;  2BWS A;  1M35 A;  1YVM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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