4IDYA

Mycobacterium tuberculosis methionine aminopeptidase type 1c in complex with 2-hydroxyethyl disulfide
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
282
structure length
281
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
total genus 87
structure length 281
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4idyA01
5E5BA 4FLJA 3CB6A 3S6BA 4IKTA 5D6EA 2BHAA 3IU7A 2EA4A 2BB7A 5CLSA 1W2MA 1W7VA 3Q6DA 3PKBA 4A6WA 4FO7A 5CIKA 3RVAA 5JHUA 3BITA 1C22A 1R58A 1M35A 3PKDA 4A6VA 2DFIA 1PV9A 4IPAA 4S00A 5JFRA 2GU5A 3CB5A 3FM3A 4S2RP 4EGEA 4FLLA 2Q8KA 1QXYA 2GG8A 1WL6A 2GG2A 2BN7A 2B3KA 4IF7A 2BWXA 2GA2A 2ZSGA 4U70A 1R5GA 2Q94A 4U76A 4U71A 4Z7MA 1C21A 4FKCA 1B59A 3BIQA 3IU8A 1WLRA 2Q93A 3IG4A 4S2TP 3FMQA 4IKSA 2BWTA 4RZYA 1YW9A 4RGZ1 2EVMA 1N51A 1KQ9A 5FCFA 2BHCA 4U73A 4FLIA 1B6AA 1R5HA 1JAWA 4U6JA 2BWWA 2GU7A 2HOWA 2EVCA 3PKCA 2NQ6A 3MX6A 1YVMA 5JI6A 2GG9A 2V3XA 1XGOA 1WKMA 3D27A 3PKEA 4U75A 2V3ZA 4U6CA 1C23A 2Q92A 4FUKA 4IKRA 4IU6A 4U6EA 4ZWUA 4IKUA 1QXZA 2GG3A 2BHBA 1WY2A 1C24A 1MATA 4HXXA 1C27A 1A16A 3TB5A 2V3YA 4PNCA 4OOKA 1YW7A 2Q96A 3PKAA 2GZ5A 2GG7A 4QR8A 4FLKA 2ADUA 4ZWPA 2GU4A 4FO8A 2MATA 4PV4A 2EA2A 1XNZA 2P98A 3L24A 4U6ZA 5CDLA 4MATA 4R60A 2GGBA 2IW2A 4B28A 2Q95A 1WN1A 2EVOA 1QZYA 1WBQA 5CE6A 2P9AA 4U69A 5D6FA 1QXWA 4ZWOA 1BN5A 1KQ0A 4RZZA 4U6WA 5CDEA 2OKNA 2BWUA 3CTZA 2V6CA 1CHMA 4IDYA 2GGCA 3MATA 1YJ3A 3MR1A 5CDVA 2BH3A 1KP0A 3RORA 3TAVA 4U1BA 2BWYA 1O0XA 4JUQA 4IECA 2GG5A 2NQ7A 3BIPA 4S01A 2GG0A 1XGMA 1Y1NA 2GTXA 4ZNGA 1XGSA 5FCHA 2BHDA 2B3HA 2G6PA 1XGNA 2B3LA 3IU9A 4KM3A 1BOAA 5CNXA 1YW8A 2OAZA 2GU6A 3L7GA 2BWVA 2BWSA 3FMRA 1WL9A 2P99A
chains in the Genus database with same CATH superfamily
5E5BA 4FLJA 3CB6A 3S6BA 4IKTA 5D6EA 2BHAA 3IU7A 2EA4A 2BB7A 5CLSA 1W2MA 1W7VA 3Q6DA 3PKBA 4A6WA 4FO7A 5CIKA 3RVAA 5JHUA 3BITA 1C22A 1R58A 1M35A 3PKDA 4A6VA 2DFIA 1PV9A 4IPAA 4S00A 5JFRA 2GU5A 3CB5A 3FM3A 4S2RP 4EGEA 4FLLA 2Q8KA 1QXYA 2GG8A 1WL6A 2GG2A 2BN7A 2B3KA 4IF7A 2BWXA 2GA2A 2ZSGA 4U70A 1R5GA 2Q94A 4U76A 4U71A 4Z7MA 1C21A 4FKCA 1B59A 3BIQA 3IU8A 1WLRA 2Q93A 3IG4A 4S2TP 3FMQA 4IKSA 2BWTA 4RZYA 1YW9A 4RGZ1 2EVMA 1N51A 1KQ9A 5FCFA 2BHCA 4U73A 4FLIA 1B6AA 1R5HA 1JAWA 4U6JA 2BWWA 2GU7A 2HOWA 2EVCA 3PKCA 2NQ6A 3MX6A 1YVMA 5JI6A 2GG9A 2V3XA 1XGOA 1WKMA 3D27A 3PKEA 4U75A 2V3ZA 4U6CA 1C23A 2Q92A 4FUKA 4IKRA 4IU6A 4U6EA 4ZWUA 4IKUA 1QXZA 2GG3A 2BHBA 1WY2A 1C24A 1MATA 4HXXA 1C27A 1A16A 3TB5A 2V3YA 4PNCA 4OOKA 1YW7A 2Q96A 3PKAA 2GZ5A 2GG7A 4QR8A 4FLKA 2ADUA 4ZWPA 2GU4A 4FO8A 2MATA 4PV4A 2EA2A 1XNZA 2P98A 3L24A 4U6ZA 5CDLA 4MATA 4R60A 2GGBA 2IW2A 4B28A 2Q95A 1WN1A 2EVOA 1QZYA 1WBQA 5CE6A 2P9AA 4U69A 5D6FA 1QXWA 4ZWOA 1BN5A 1KQ0A 4RZZA 4U6WA 5CDEA 2OKNA 2BWUA 3CTZA 2V6CA 1CHMA 4IDYA 2GGCA 3MATA 1YJ3A 3MR1A 5CDVA 2BH3A 1KP0A 3RORA 3TAVA 4U1BA 2BWYA 1O0XA 4JUQA 4IECA 2GG5A 2NQ7A 3BIPA 4S01A 2GG0A 1XGMA 1Y1NA 2GTXA 4ZNGA 1XGSA 5FCHA 2BHDA 2B3HA 2G6PA 1XGNA 2B3LA 3IU9A 4KM3A 1BOAA 5CNXA 1YW8A 2OAZA 2GU6A 3L7GA 2BWVA 2BWSA 3FMRA 1WL9A 2P99A
chains in the Genus database with same CATH topology
5E5BA 4FLJA 3CB6A 3S6BA 4IKTA 5D6EA 2BHAA 3IU7A 2EA4A 2BB7A 5CLSA 1W2MA 1W7VA 3Q6DA 3PKBA 4A6WA 4FO7A 5CIKA 3RVAA 5JHUA 3BITA 1C22A 1R58A 1M35A 3PKDA 4A6VA 2DFIA 1PV9A 4IPAA 4S00A 5JFRA 2GU5A 3CB5A 3FM3A 4S2RP 4EGEA 4FLLA 2Q8KA 1QXYA 2GG8A 1WL6A 2GG2A 2BN7A 2B3KA 4IF7A 2BWXA 2GA2A 2ZSGA 4U70A 1R5GA 2Q94A 4U76A 4U71A 4Z7MA 1C21A 4FKCA 1B59A 3BIQA 3IU8A 1WLRA 2Q93A 3IG4A 4S2TP 3FMQA 4IKSA 2BWTA 4RZYA 1YW9A 4RGZ1 2EVMA 1N51A 1KQ9A 5FCFA 2BHCA 4U73A 4FLIA 1B6AA 1R5HA 1JAWA 4U6JA 2BWWA 2GU7A 2HOWA 2EVCA 3PKCA 2NQ6A 3MX6A 1YVMA 5JI6A 2GG9A 2V3XA 1XGOA 1WKMA 3D27A 3PKEA 4U75A 2V3ZA 4U6CA 1C23A 2Q92A 4FUKA 4IKRA 4IU6A 4U6EA 4ZWUA 4IKUA 1QXZA 2GG3A 2BHBA 1WY2A 1C24A 1MATA 4HXXA 1C27A 1A16A 3TB5A 2V3YA 4PNCA 4OOKA 1YW7A 2Q96A 3PKAA 2GZ5A 2GG7A 4QR8A 4FLKA 2ADUA 4ZWPA 2GU4A 4FO8A 2MATA 4PV4A 2EA2A 1XNZA 2P98A 3L24A 4U6ZA 5CDLA 4MATA 4R60A 2GGBA 2IW2A 4B28A 2Q95A 1WN1A 2EVOA 1QZYA 1WBQA 5CE6A 2P9AA 4U69A 5D6FA 1QXWA 4ZWOA 1BN5A 1KQ0A 4RZZA 4U6WA 5CDEA 2OKNA 2BWUA 3CTZA 2V6CA 1CHMA 4IDYA 2GGCA 3MATA 1YJ3A 3MR1A 5CDVA 2BH3A 1KP0A 3RORA 3TAVA 4U1BA 2BWYA 1O0XA 4JUQA 4IECA 2GG5A 2NQ7A 3BIPA 4S01A 2GG0A 1XGMA 1Y1NA 2GTXA 4ZNGA 1XGSA 5FCHA 2BHDA 2B3HA 2G6PA 1XGNA 2B3LA 3IU9A 4KM3A 1BOAA 5CNXA 1YW8A 2OAZA 2GU6A 3L7GA 2BWVA 2BWSA 3FMRA 1WL9A 2P99A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5E5B A;  4FLJ A;  3CB6 A;  3S6B A;  4IKT A;  5D6E A;  2BHA A;  3IU7 A;  2EA4 A;  2BB7 A;  5CLS A;  1W2M A;  1W7V A;  3Q6D A;  3PKB A;  4A6W A;  4FO7 A;  5CIK A;  3RVA A;  5JHU A;  3BIT A;  1C22 A;  1R58 A;  1M35 A;  3PKD A;  4A6V A;  2DFI A;  1PV9 A;  4IPA A;  4S00 A;  5JFR A;  2GU5 A;  3CB5 A;  3FM3 A;  4S2R P;  4EGE A;  4FLL A;  2Q8K A;  1QXY A;  2GG8 A;  1WL6 A;  2GG2 A;  2BN7 A;  2B3K A;  4IF7 A;  2BWX A;  2GA2 A;  2ZSG A;  4U70 A;  1R5G A;  2Q94 A;  4U76 A;  4U71 A;  4Z7M A;  1C21 A;  4FKC A;  1B59 A;  3BIQ A;  3IU8 A;  1WLR A;  2Q93 A;  3IG4 A;  4S2T P;  3FMQ A;  4IKS A;  2BWT A;  4RZY A;  1YW9 A;  4RGZ 1;  2EVM A;  1N51 A;  1KQ9 A;  5FCF A;  2BHC A;  4U73 A;  4FLI A;  1B6A A;  1R5H A;  1JAW A;  4U6J A;  2BWW A;  2GU7 A;  2HOW A;  2EVC A;  3PKC A;  2NQ6 A;  3MX6 A;  1YVM A;  5JI6 A;  2GG9 A;  2V3X A;  1XGO A;  1WKM A;  3D27 A;  3PKE A;  4U75 A;  2V3Z A;  4U6C A;  1C23 A;  2Q92 A;  4FUK A;  4IKR A;  4IU6 A;  4U6E A;  4ZWU A;  4IKU A;  1QXZ A;  2GG3 A;  2BHB A;  1WY2 A;  1C24 A;  1MAT A;  4HXX A;  1C27 A;  1A16 A;  3TB5 A;  2V3Y A;  4PNC A;  4OOK A;  1YW7 A;  2Q96 A;  3PKA A;  2GZ5 A;  2GG7 A;  4QR8 A;  4FLK A;  2ADU A;  4ZWP A;  2GU4 A;  4FO8 A;  2MAT A;  4PV4 A;  2EA2 A;  1XNZ A;  2P98 A;  3L24 A;  4U6Z A;  5CDL A;  4MAT A;  4R60 A;  2GGB A;  2IW2 A;  4B28 A;  2Q95 A;  1WN1 A;  2EVO A;  1QZY A;  1WBQ A;  5CE6 A;  2P9A A;  4U69 A;  5D6F A;  1QXW A;  4ZWO A;  1BN5 A;  1KQ0 A;  4RZZ A;  4U6W A;  5CDE A;  2OKN A;  2BWU A;  3CTZ A;  2V6C A;  1CHM A;  4IDY A;  2GGC A;  3MAT A;  1YJ3 A;  3MR1 A;  5CDV A;  2BH3 A;  1KP0 A;  3ROR A;  3TAV A;  4U1B A;  2BWY A;  1O0X A;  4JUQ A;  4IEC A;  2GG5 A;  2NQ7 A;  3BIP A;  4S01 A;  2GG0 A;  1XGM A;  1Y1N A;  2GTX A;  4ZNG A;  1XGS A;  5FCH A;  2BHD A;  2B3H A;  2G6P A;  1XGN A;  2B3L A;  3IU9 A;  4KM3 A;  1BOA A;  5CNX A;  1YW8 A;  2OAZ A;  2GU6 A;  3L7G A;  2BWV A;  2BWS A;  3FMR A;  1WL9 A;  2P99 A; 
#chains in the Genus database with same CATH topology
 5E5B A;  4FLJ A;  3CB6 A;  3S6B A;  4IKT A;  5D6E A;  2BHA A;  3IU7 A;  2EA4 A;  2BB7 A;  5CLS A;  1W2M A;  1W7V A;  3Q6D A;  3PKB A;  4A6W A;  4FO7 A;  5CIK A;  3RVA A;  5JHU A;  3BIT A;  1C22 A;  1R58 A;  1M35 A;  3PKD A;  4A6V A;  2DFI A;  1PV9 A;  4IPA A;  4S00 A;  5JFR A;  2GU5 A;  3CB5 A;  3FM3 A;  4S2R P;  4EGE A;  4FLL A;  2Q8K A;  1QXY A;  2GG8 A;  1WL6 A;  2GG2 A;  2BN7 A;  2B3K A;  4IF7 A;  2BWX A;  2GA2 A;  2ZSG A;  4U70 A;  1R5G A;  2Q94 A;  4U76 A;  4U71 A;  4Z7M A;  1C21 A;  4FKC A;  1B59 A;  3BIQ A;  3IU8 A;  1WLR A;  2Q93 A;  3IG4 A;  4S2T P;  3FMQ A;  4IKS A;  2BWT A;  4RZY A;  1YW9 A;  4RGZ 1;  2EVM A;  1N51 A;  1KQ9 A;  5FCF A;  2BHC A;  4U73 A;  4FLI A;  1B6A A;  1R5H A;  1JAW A;  4U6J A;  2BWW A;  2GU7 A;  2HOW A;  2EVC A;  3PKC A;  2NQ6 A;  3MX6 A;  1YVM A;  5JI6 A;  2GG9 A;  2V3X A;  1XGO A;  1WKM A;  3D27 A;  3PKE A;  4U75 A;  2V3Z A;  4U6C A;  1C23 A;  2Q92 A;  4FUK A;  4IKR A;  4IU6 A;  4U6E A;  4ZWU A;  4IKU A;  1QXZ A;  2GG3 A;  2BHB A;  1WY2 A;  1C24 A;  1MAT A;  4HXX A;  1C27 A;  1A16 A;  3TB5 A;  2V3Y A;  4PNC A;  4OOK A;  1YW7 A;  2Q96 A;  3PKA A;  2GZ5 A;  2GG7 A;  4QR8 A;  4FLK A;  2ADU A;  4ZWP A;  2GU4 A;  4FO8 A;  2MAT A;  4PV4 A;  2EA2 A;  1XNZ A;  2P98 A;  3L24 A;  4U6Z A;  5CDL A;  4MAT A;  4R60 A;  2GGB A;  2IW2 A;  4B28 A;  2Q95 A;  1WN1 A;  2EVO A;  1QZY A;  1WBQ A;  5CE6 A;  2P9A A;  4U69 A;  5D6F A;  1QXW A;  4ZWO A;  1BN5 A;  1KQ0 A;  4RZZ A;  4U6W A;  5CDE A;  2OKN A;  2BWU A;  3CTZ A;  2V6C A;  1CHM A;  4IDY A;  2GGC A;  3MAT A;  1YJ3 A;  3MR1 A;  5CDV A;  2BH3 A;  1KP0 A;  3ROR A;  3TAV A;  4U1B A;  2BWY A;  1O0X A;  4JUQ A;  4IEC A;  2GG5 A;  2NQ7 A;  3BIP A;  4S01 A;  2GG0 A;  1XGM A;  1Y1N A;  2GTX A;  4ZNG A;  1XGS A;  5FCH A;  2BHD A;  2B3H A;  2G6P A;  1XGN A;  2B3L A;  3IU9 A;  4KM3 A;  1BOA A;  5CNX A;  1YW8 A;  2OAZ A;  2GU6 A;  3L7G A;  2BWV A;  2BWS A;  3FMR A;  1WL9 A;  2P99 A; 
#chains in the Genus database with same CATH homology
 5E5B A;  4FLJ A;  3CB6 A;  3S6B A;  4IKT A;  5D6E A;  2BHA A;  3IU7 A;  2EA4 A;  2BB7 A;  5CLS A;  1W2M A;  1W7V A;  3Q6D A;  3PKB A;  4A6W A;  4FO7 A;  5CIK A;  3RVA A;  5JHU A;  3BIT A;  1C22 A;  1R58 A;  1M35 A;  3PKD A;  4A6V A;  2DFI A;  1PV9 A;  4IPA A;  4S00 A;  5JFR A;  2GU5 A;  3CB5 A;  3FM3 A;  4S2R P;  4EGE A;  4FLL A;  2Q8K A;  1QXY A;  2GG8 A;  1WL6 A;  2GG2 A;  2BN7 A;  2B3K A;  4IF7 A;  2BWX A;  2GA2 A;  2ZSG A;  4U70 A;  1R5G A;  2Q94 A;  4U76 A;  4U71 A;  4Z7M A;  1C21 A;  4FKC A;  1B59 A;  3BIQ A;  3IU8 A;  1WLR A;  2Q93 A;  3IG4 A;  4S2T P;  3FMQ A;  4IKS A;  2BWT A;  4RZY A;  1YW9 A;  4RGZ 1;  2EVM A;  1N51 A;  1KQ9 A;  5FCF A;  2BHC A;  4U73 A;  4FLI A;  1B6A A;  1R5H A;  1JAW A;  4U6J A;  2BWW A;  2GU7 A;  2HOW A;  2EVC A;  3PKC A;  2NQ6 A;  3MX6 A;  1YVM A;  5JI6 A;  2GG9 A;  2V3X A;  1XGO A;  1WKM A;  3D27 A;  3PKE A;  4U75 A;  2V3Z A;  4U6C A;  1C23 A;  2Q92 A;  4FUK A;  4IKR A;  4IU6 A;  4U6E A;  4ZWU A;  4IKU A;  1QXZ A;  2GG3 A;  2BHB A;  1WY2 A;  1C24 A;  1MAT A;  4HXX A;  1C27 A;  1A16 A;  3TB5 A;  2V3Y A;  4PNC A;  4OOK A;  1YW7 A;  2Q96 A;  3PKA A;  2GZ5 A;  2GG7 A;  4QR8 A;  4FLK A;  2ADU A;  4ZWP A;  2GU4 A;  4FO8 A;  2MAT A;  4PV4 A;  2EA2 A;  1XNZ A;  2P98 A;  3L24 A;  4U6Z A;  5CDL A;  4MAT A;  4R60 A;  2GGB A;  2IW2 A;  4B28 A;  2Q95 A;  1WN1 A;  2EVO A;  1QZY A;  1WBQ A;  5CE6 A;  2P9A A;  4U69 A;  5D6F A;  1QXW A;  4ZWO A;  1BN5 A;  1KQ0 A;  4RZZ A;  4U6W A;  5CDE A;  2OKN A;  2BWU A;  3CTZ A;  2V6C A;  1CHM A;  4IDY A;  2GGC A;  3MAT A;  1YJ3 A;  3MR1 A;  5CDV A;  2BH3 A;  1KP0 A;  3ROR A;  3TAV A;  4U1B A;  2BWY A;  1O0X A;  4JUQ A;  4IEC A;  2GG5 A;  2NQ7 A;  3BIP A;  4S01 A;  2GG0 A;  1XGM A;  1Y1N A;  2GTX A;  4ZNG A;  1XGS A;  5FCH A;  2BHD A;  2B3H A;  2G6P A;  1XGN A;  2B3L A;  3IU9 A;  4KM3 A;  1BOA A;  5CNX A;  1YW8 A;  2OAZ A;  2GU6 A;  3L7G A;  2BWV A;  2BWS A;  3FMR A;  1WL9 A;  2P99 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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