1YVMA

E. coli methionine aminopeptidase in complex with thiabendazole
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Metal Ions as Cofactors for the Binding of Inhibitors to Methionine Aminopeptidase: A Critical View of the Relevance of In Vitro Metalloenzyme Assays.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Escherichia coli
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1yvmA00
4S01A 5CE6A 2BWSA 2P99A 3CB5A 2GG8A 3MATA 1C22A 4FUKA 2BHDA 2GG0A 1WKMA 4U70A 2GZ5A 1R58A 1C21A 5CIKA 1R5GA 1QXYA 1WLRA 2V3XA 3PKBA 2B3HA 3BIPA 4ZWPA 1Y1NA 1CHMA 2BH3A 5D6FA 2DFIA 3PKEA 4EGEA 2ADUA 1KQ9A 4S2TP 1XGSA 3CTZA 4U71A 1W7VA 3PKCA 3S6BA 2BWUA 2EVMA 4ZWUA 2EVCA 2BHBA 2GTXA 1A16A 2GG2A 1PV9A 1YW7A 4U75A 4U6CA 4U76A 2OKNA 2MATA 1WY2A 2B3KA 2IW2A 3IU7A 5FCHA 3PKAA 1YW8A 1WL9A 5JI6A 5CNXA 1C24A 1QXWA 2GGBA 2EVOA 3FMQA 3MX6A 2Q96A 2BHCA 4FLKA 1XGOA 3TAVA 2NQ7A 3L7GA 3Q6DA 5CDLA 2GU7A 1KQ0A 2Q93A 5D6EA 4IPAA 3RVAA 2BB7A 1C23A 2GG7A 3MR1A 4RZYA 4B28A 1BOAA 4Z7MA 5E5BA 1MATA 5JHUA 5JFRA 4R60A 4U6EA 4PV4A 1JAWA 4HXXA 4S00A 5CLSA 1XGNA 2GU4A 4FLLA 4FO7A 2B3LA 2BWYA 4RGZ1 3D27A 1KP0A 1YW9A 2P9AA 4IKTA 2V3YA 4JUQA 4FKCA 2Q92A 2G6PA 3BIQA 2Q8KA 2HOWA 3CB6A 5FCFA 4IKUA 4IECA 4U69A 2P98A 1YJ3A 2GU6A 2Q94A 4U6WA 2EA2A 4RZZA 1B59A 1C27A 1YVMA 3TB5A 3IU8A 2GGCA 2BN7A 2Q95A 3IG4A 4IKSA 2GG3A 1QZYA 4IU6A 3FMRA 4ZWOA 1WL6A 1W2MA 3IU9A 1N51A 3L24A 2V3ZA 2GG9A 4S2RP 1WN1A 4A6WA 1M35A 1XGMA 4OOKA 4U6ZA 1BN5A 2BWXA 1B6AA 4QR8A 1XNZA 1QXZA 2BWTA 2GU5A 4IKRA 2NQ6A 2EA4A 2OAZA 3RORA 1R5HA 1WBQA 4PNCA 3BITA 2GA2A 4A6VA 4FLJA 4KM3A 3PKDA 1O0XA 2BWWA 5CDVA 2GG5A 4U1BA 4U6JA 2BWVA 3FM3A 2V6CA 4ZNGA 4U73A 4FLIA 4IDYA 4FO8A 2ZSGA 4MATA 2BHAA 4IF7A 5CDEA
chains in the Genus database with same CATH superfamily
4S01A 5CE6A 2BWSA 2P99A 3CB5A 2GG8A 3MATA 1C22A 4FUKA 2BHDA 2GG0A 1WKMA 4U70A 2GZ5A 1R58A 1C21A 5CIKA 1R5GA 1QXYA 1WLRA 2V3XA 3PKBA 2B3HA 3BIPA 4ZWPA 1Y1NA 1CHMA 2BH3A 5D6FA 2DFIA 3PKEA 4EGEA 2ADUA 1KQ9A 4S2TP 1XGSA 3CTZA 4U71A 1W7VA 3PKCA 3S6BA 2BWUA 2EVMA 4ZWUA 2EVCA 2BHBA 2GTXA 1A16A 2GG2A 1PV9A 1YW7A 4U75A 4U6CA 4U76A 2OKNA 2MATA 1WY2A 2B3KA 2IW2A 3IU7A 5FCHA 3PKAA 1YW8A 1WL9A 5JI6A 5CNXA 1C24A 1QXWA 2GGBA 2EVOA 3FMQA 3MX6A 2Q96A 2BHCA 4FLKA 1XGOA 3TAVA 2NQ7A 3L7GA 3Q6DA 5CDLA 2GU7A 1KQ0A 2Q93A 5D6EA 4IPAA 3RVAA 2BB7A 1C23A 2GG7A 3MR1A 4RZYA 4B28A 1BOAA 4Z7MA 5E5BA 1MATA 5JHUA 5JFRA 4R60A 4U6EA 4PV4A 1JAWA 4HXXA 4S00A 5CLSA 1XGNA 2GU4A 4FLLA 4FO7A 2B3LA 2BWYA 4RGZ1 3D27A 1KP0A 1YW9A 2P9AA 4IKTA 2V3YA 4JUQA 4FKCA 2Q92A 2G6PA 3BIQA 2Q8KA 2HOWA 3CB6A 5FCFA 4IKUA 4IECA 4U69A 2P98A 1YJ3A 2GU6A 2Q94A 4U6WA 2EA2A 4RZZA 1B59A 1C27A 1YVMA 3TB5A 3IU8A 2GGCA 2BN7A 2Q95A 3IG4A 4IKSA 2GG3A 1QZYA 4IU6A 3FMRA 4ZWOA 1WL6A 1W2MA 3IU9A 1N51A 3L24A 2V3ZA 2GG9A 4S2RP 1WN1A 4A6WA 1M35A 1XGMA 4OOKA 4U6ZA 1BN5A 2BWXA 1B6AA 4QR8A 1XNZA 1QXZA 2BWTA 2GU5A 4IKRA 2NQ6A 2EA4A 2OAZA 3RORA 1R5HA 1WBQA 4PNCA 3BITA 2GA2A 4A6VA 4FLJA 4KM3A 3PKDA 1O0XA 2BWWA 5CDVA 2GG5A 4U1BA 4U6JA 2BWVA 3FM3A 2V6CA 4ZNGA 4U73A 4FLIA 4IDYA 4FO8A 2ZSGA 4MATA 2BHAA 4IF7A 5CDEA
chains in the Genus database with same CATH topology
4S01A 5CE6A 2BWSA 2P99A 3CB5A 2GG8A 3MATA 1C22A 4FUKA 2BHDA 2GG0A 1WKMA 4U70A 2GZ5A 1R58A 1C21A 5CIKA 1R5GA 1QXYA 1WLRA 2V3XA 3PKBA 2B3HA 3BIPA 4ZWPA 1Y1NA 1CHMA 2BH3A 5D6FA 2DFIA 3PKEA 4EGEA 2ADUA 1KQ9A 4S2TP 1XGSA 3CTZA 4U71A 1W7VA 3PKCA 3S6BA 2BWUA 2EVMA 4ZWUA 2EVCA 2BHBA 2GTXA 1A16A 2GG2A 1PV9A 1YW7A 4U75A 4U6CA 4U76A 2OKNA 2MATA 1WY2A 2B3KA 2IW2A 3IU7A 5FCHA 3PKAA 1YW8A 1WL9A 5JI6A 5CNXA 1C24A 1QXWA 2GGBA 2EVOA 3FMQA 3MX6A 2Q96A 2BHCA 4FLKA 1XGOA 3TAVA 2NQ7A 3L7GA 3Q6DA 5CDLA 2GU7A 1KQ0A 2Q93A 5D6EA 4IPAA 3RVAA 2BB7A 1C23A 2GG7A 3MR1A 4RZYA 4B28A 1BOAA 4Z7MA 5E5BA 1MATA 5JHUA 5JFRA 4R60A 4U6EA 4PV4A 1JAWA 4HXXA 4S00A 5CLSA 1XGNA 2GU4A 4FLLA 4FO7A 2B3LA 2BWYA 4RGZ1 3D27A 1KP0A 1YW9A 2P9AA 4IKTA 2V3YA 4JUQA 4FKCA 2Q92A 2G6PA 3BIQA 2Q8KA 2HOWA 3CB6A 5FCFA 4IKUA 4IECA 4U69A 2P98A 1YJ3A 2GU6A 2Q94A 4U6WA 2EA2A 4RZZA 1B59A 1C27A 1YVMA 3TB5A 3IU8A 2GGCA 2BN7A 2Q95A 3IG4A 4IKSA 2GG3A 1QZYA 4IU6A 3FMRA 4ZWOA 1WL6A 1W2MA 3IU9A 1N51A 3L24A 2V3ZA 2GG9A 4S2RP 1WN1A 4A6WA 1M35A 1XGMA 4OOKA 4U6ZA 1BN5A 2BWXA 1B6AA 4QR8A 1XNZA 1QXZA 2BWTA 2GU5A 4IKRA 2NQ6A 2EA4A 2OAZA 3RORA 1R5HA 1WBQA 4PNCA 3BITA 2GA2A 4A6VA 4FLJA 4KM3A 3PKDA 1O0XA 2BWWA 5CDVA 2GG5A 4U1BA 4U6JA 2BWVA 3FM3A 2V6CA 4ZNGA 4U73A 4FLIA 4IDYA 4FO8A 2ZSGA 4MATA 2BHAA 4IF7A 5CDEA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4S01 A;  5CE6 A;  2BWS A;  2P99 A;  3CB5 A;  2GG8 A;  3MAT A;  1C22 A;  4FUK A;  2BHD A;  2GG0 A;  1WKM A;  4U70 A;  2GZ5 A;  1R58 A;  1C21 A;  5CIK A;  1R5G A;  1QXY A;  1WLR A;  2V3X A;  3PKB A;  2B3H A;  3BIP A;  4ZWP A;  1Y1N A;  1CHM A;  2BH3 A;  5D6F A;  2DFI A;  3PKE A;  4EGE A;  2ADU A;  1KQ9 A;  4S2T P;  1XGS A;  3CTZ A;  4U71 A;  1W7V A;  3PKC A;  3S6B A;  2BWU A;  2EVM A;  4ZWU A;  2EVC A;  2BHB A;  2GTX A;  1A16 A;  2GG2 A;  1PV9 A;  1YW7 A;  4U75 A;  4U6C A;  4U76 A;  2OKN A;  2MAT A;  1WY2 A;  2B3K A;  2IW2 A;  3IU7 A;  5FCH A;  3PKA A;  1YW8 A;  1WL9 A;  5JI6 A;  5CNX A;  1C24 A;  1QXW A;  2GGB A;  2EVO A;  3FMQ A;  3MX6 A;  2Q96 A;  2BHC A;  4FLK A;  1XGO A;  3TAV A;  2NQ7 A;  3L7G A;  3Q6D A;  5CDL A;  2GU7 A;  1KQ0 A;  2Q93 A;  5D6E A;  4IPA A;  3RVA A;  2BB7 A;  1C23 A;  2GG7 A;  3MR1 A;  4RZY A;  4B28 A;  1BOA A;  4Z7M A;  5E5B A;  1MAT A;  5JHU A;  5JFR A;  4R60 A;  4U6E A;  4PV4 A;  1JAW A;  4HXX A;  4S00 A;  5CLS A;  1XGN A;  2GU4 A;  4FLL A;  4FO7 A;  2B3L A;  2BWY A;  4RGZ 1;  3D27 A;  1KP0 A;  1YW9 A;  2P9A A;  4IKT A;  2V3Y A;  4JUQ A;  4FKC A;  2Q92 A;  2G6P A;  3BIQ A;  2Q8K A;  2HOW A;  3CB6 A;  5FCF A;  4IKU A;  4IEC A;  4U69 A;  2P98 A;  1YJ3 A;  2GU6 A;  2Q94 A;  4U6W A;  2EA2 A;  4RZZ A;  1B59 A;  1C27 A;  1YVM A;  3TB5 A;  3IU8 A;  2GGC A;  2BN7 A;  2Q95 A;  3IG4 A;  4IKS A;  2GG3 A;  1QZY A;  4IU6 A;  3FMR A;  4ZWO A;  1WL6 A;  1W2M A;  3IU9 A;  1N51 A;  3L24 A;  2V3Z A;  2GG9 A;  4S2R P;  1WN1 A;  4A6W A;  1M35 A;  1XGM A;  4OOK A;  4U6Z A;  1BN5 A;  2BWX A;  1B6A A;  4QR8 A;  1XNZ A;  1QXZ A;  2BWT A;  2GU5 A;  4IKR A;  2NQ6 A;  2EA4 A;  2OAZ A;  3ROR A;  1R5H A;  1WBQ A;  4PNC A;  3BIT A;  2GA2 A;  4A6V A;  4FLJ A;  4KM3 A;  3PKD A;  1O0X A;  2BWW A;  5CDV A;  2GG5 A;  4U1B A;  4U6J A;  2BWV A;  3FM3 A;  2V6C A;  4ZNG A;  4U73 A;  4FLI A;  4IDY A;  4FO8 A;  2ZSG A;  4MAT A;  2BHA A;  4IF7 A;  5CDE A; 
#chains in the Genus database with same CATH topology
 4S01 A;  5CE6 A;  2BWS A;  2P99 A;  3CB5 A;  2GG8 A;  3MAT A;  1C22 A;  4FUK A;  2BHD A;  2GG0 A;  1WKM A;  4U70 A;  2GZ5 A;  1R58 A;  1C21 A;  5CIK A;  1R5G A;  1QXY A;  1WLR A;  2V3X A;  3PKB A;  2B3H A;  3BIP A;  4ZWP A;  1Y1N A;  1CHM A;  2BH3 A;  5D6F A;  2DFI A;  3PKE A;  4EGE A;  2ADU A;  1KQ9 A;  4S2T P;  1XGS A;  3CTZ A;  4U71 A;  1W7V A;  3PKC A;  3S6B A;  2BWU A;  2EVM A;  4ZWU A;  2EVC A;  2BHB A;  2GTX A;  1A16 A;  2GG2 A;  1PV9 A;  1YW7 A;  4U75 A;  4U6C A;  4U76 A;  2OKN A;  2MAT A;  1WY2 A;  2B3K A;  2IW2 A;  3IU7 A;  5FCH A;  3PKA A;  1YW8 A;  1WL9 A;  5JI6 A;  5CNX A;  1C24 A;  1QXW A;  2GGB A;  2EVO A;  3FMQ A;  3MX6 A;  2Q96 A;  2BHC A;  4FLK A;  1XGO A;  3TAV A;  2NQ7 A;  3L7G A;  3Q6D A;  5CDL A;  2GU7 A;  1KQ0 A;  2Q93 A;  5D6E A;  4IPA A;  3RVA A;  2BB7 A;  1C23 A;  2GG7 A;  3MR1 A;  4RZY A;  4B28 A;  1BOA A;  4Z7M A;  5E5B A;  1MAT A;  5JHU A;  5JFR A;  4R60 A;  4U6E A;  4PV4 A;  1JAW A;  4HXX A;  4S00 A;  5CLS A;  1XGN A;  2GU4 A;  4FLL A;  4FO7 A;  2B3L A;  2BWY A;  4RGZ 1;  3D27 A;  1KP0 A;  1YW9 A;  2P9A A;  4IKT A;  2V3Y A;  4JUQ A;  4FKC A;  2Q92 A;  2G6P A;  3BIQ A;  2Q8K A;  2HOW A;  3CB6 A;  5FCF A;  4IKU A;  4IEC A;  4U69 A;  2P98 A;  1YJ3 A;  2GU6 A;  2Q94 A;  4U6W A;  2EA2 A;  4RZZ A;  1B59 A;  1C27 A;  1YVM A;  3TB5 A;  3IU8 A;  2GGC A;  2BN7 A;  2Q95 A;  3IG4 A;  4IKS A;  2GG3 A;  1QZY A;  4IU6 A;  3FMR A;  4ZWO A;  1WL6 A;  1W2M A;  3IU9 A;  1N51 A;  3L24 A;  2V3Z A;  2GG9 A;  4S2R P;  1WN1 A;  4A6W A;  1M35 A;  1XGM A;  4OOK A;  4U6Z A;  1BN5 A;  2BWX A;  1B6A A;  4QR8 A;  1XNZ A;  1QXZ A;  2BWT A;  2GU5 A;  4IKR A;  2NQ6 A;  2EA4 A;  2OAZ A;  3ROR A;  1R5H A;  1WBQ A;  4PNC A;  3BIT A;  2GA2 A;  4A6V A;  4FLJ A;  4KM3 A;  3PKD A;  1O0X A;  2BWW A;  5CDV A;  2GG5 A;  4U1B A;  4U6J A;  2BWV A;  3FM3 A;  2V6C A;  4ZNG A;  4U73 A;  4FLI A;  4IDY A;  4FO8 A;  2ZSG A;  4MAT A;  2BHA A;  4IF7 A;  5CDE A; 
#chains in the Genus database with same CATH homology
 4S01 A;  5CE6 A;  2BWS A;  2P99 A;  3CB5 A;  2GG8 A;  3MAT A;  1C22 A;  4FUK A;  2BHD A;  2GG0 A;  1WKM A;  4U70 A;  2GZ5 A;  1R58 A;  1C21 A;  5CIK A;  1R5G A;  1QXY A;  1WLR A;  2V3X A;  3PKB A;  2B3H A;  3BIP A;  4ZWP A;  1Y1N A;  1CHM A;  2BH3 A;  5D6F A;  2DFI A;  3PKE A;  4EGE A;  2ADU A;  1KQ9 A;  4S2T P;  1XGS A;  3CTZ A;  4U71 A;  1W7V A;  3PKC A;  3S6B A;  2BWU A;  2EVM A;  4ZWU A;  2EVC A;  2BHB A;  2GTX A;  1A16 A;  2GG2 A;  1PV9 A;  1YW7 A;  4U75 A;  4U6C A;  4U76 A;  2OKN A;  2MAT A;  1WY2 A;  2B3K A;  2IW2 A;  3IU7 A;  5FCH A;  3PKA A;  1YW8 A;  1WL9 A;  5JI6 A;  5CNX A;  1C24 A;  1QXW A;  2GGB A;  2EVO A;  3FMQ A;  3MX6 A;  2Q96 A;  2BHC A;  4FLK A;  1XGO A;  3TAV A;  2NQ7 A;  3L7G A;  3Q6D A;  5CDL A;  2GU7 A;  1KQ0 A;  2Q93 A;  5D6E A;  4IPA A;  3RVA A;  2BB7 A;  1C23 A;  2GG7 A;  3MR1 A;  4RZY A;  4B28 A;  1BOA A;  4Z7M A;  5E5B A;  1MAT A;  5JHU A;  5JFR A;  4R60 A;  4U6E A;  4PV4 A;  1JAW A;  4HXX A;  4S00 A;  5CLS A;  1XGN A;  2GU4 A;  4FLL A;  4FO7 A;  2B3L A;  2BWY A;  4RGZ 1;  3D27 A;  1KP0 A;  1YW9 A;  2P9A A;  4IKT A;  2V3Y A;  4JUQ A;  4FKC A;  2Q92 A;  2G6P A;  3BIQ A;  2Q8K A;  2HOW A;  3CB6 A;  5FCF A;  4IKU A;  4IEC A;  4U69 A;  2P98 A;  1YJ3 A;  2GU6 A;  2Q94 A;  4U6W A;  2EA2 A;  4RZZ A;  1B59 A;  1C27 A;  1YVM A;  3TB5 A;  3IU8 A;  2GGC A;  2BN7 A;  2Q95 A;  3IG4 A;  4IKS A;  2GG3 A;  1QZY A;  4IU6 A;  3FMR A;  4ZWO A;  1WL6 A;  1W2M A;  3IU9 A;  1N51 A;  3L24 A;  2V3Z A;  2GG9 A;  4S2R P;  1WN1 A;  4A6W A;  1M35 A;  1XGM A;  4OOK A;  4U6Z A;  1BN5 A;  2BWX A;  1B6A A;  4QR8 A;  1XNZ A;  1QXZ A;  2BWT A;  2GU5 A;  4IKR A;  2NQ6 A;  2EA4 A;  2OAZ A;  3ROR A;  1R5H A;  1WBQ A;  4PNC A;  3BIT A;  2GA2 A;  4A6V A;  4FLJ A;  4KM3 A;  3PKD A;  1O0X A;  2BWW A;  5CDV A;  2GG5 A;  4U1B A;  4U6J A;  2BWV A;  3FM3 A;  2V6C A;  4ZNG A;  4U73 A;  4FLI A;  4IDY A;  4FO8 A;  2ZSG A;  4MAT A;  2BHA A;  4IF7 A;  5CDE A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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