4PNCA

E. coli methionine aminopeptidase in complex with inhibitor 7-methoxy-2-methylen-3,4-dihydronaphthalen-1(2h)-one
Total Genus 88
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords Methionine aminopeptidase
publication title Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4pncA00
5JFRA 1R5GA 4HXXA 4IF7A 4PNCA 4U1BA 1WY2A 1XGSA 2OKNA 1A16A 4RGZ1 4Z7MA 2GG8A 5JHUA 4U6ZA 2BHAA 2Q95A 3PKDA 2V6CA 1WKMA 2GG3A 2Q8KA 1C23A 4R60A 4S00A 1XGMA 1BOAA 1N51A 2Q93A 3FMQA 4S2TP 1M35A 5FCFA 2EVMA 3IU8A 4IDYA 1O0XA 4U73A 5D6FA 1CHMA 2ZSGA 3MR1A 2OAZA 2BWWA 1XGOA 3CB5A 4U70A 4FUKA 1KP0A 2EA2A 4RZYA 3CB6A 4FLJA 1BN5A 2BB7A 2GA2A 4FLKA 4FO7A 2BHBA 2BWVA 3BITA 2GGCA 3IU7A 3RORA 5CDEA 5CDLA 4A6WA 3BIPA 2EVCA 1QZYA 5CIKA 4MATA 2BWXA 3IU9A 1R5HA 2P99A 2Q92A 2GU5A 2P9AA 4IPAA 5D6EA 5CDVA 2BWYA 3TAVA 4U76A 2MATA 1C22A 4IKUA 1W2MA 1YW9A 2EVOA 2GU7A 3IG4A 3Q6DA 2DFIA 4JUQA 4S2RP 2GU6A 2G6PA 1XGNA 4KM3A 2GGBA 2GTXA 3CTZA 4ZWPA 3MX6A 3PKEA 3D27A 1WBQA 4QR8A 5CLSA 3L24A 1W7VA 4B28A 2BN7A 3S6BA 5FCHA 4U71A 2Q96A 4U75A 1C21A 1KQ0A 4U69A 1QXYA 4IKRA 3PKCA 4IECA 1WN1A 4U6WA 4U6EA 1B6AA 2B3KA 4RZZA 1YVMA 1B59A 2Q94A 2NQ6A 4U6CA 4EGEA 4A6VA 2BWUA 2IW2A 2HOWA 2V3XA 4ZNGA 2GG0A 4IKTA 3PKAA 2V3ZA 1WL9A 1JAWA 2BHDA 3MATA 2V3YA 1WLRA 3BIQA 4ZWOA 2GG7A 5CNXA 1YJ3A 2NQ7A 3PKBA 1C27A 2B3LA 1YW8A 1R58A 5JI6A 2ADUA 3TB5A 2GZ5A 4PV4A 1WL6A 3L7GA 2EA4A 2BWSA 4IU6A 1QXZA 2GG5A 4FO8A 2GU4A 2GG2A 2BWTA 1MATA 3FM3A 1QXWA 4FLIA 4FLLA 2BHCA 4OOKA 1Y1NA 2B3HA 4IKSA 5CE6A 2P98A 1C24A 3FMRA 4FKCA 5E5BA 1YW7A 3RVAA 4U6JA 2GG9A 4ZWUA 1XNZA 4S01A 1PV9A 2BH3A 1KQ9A
chains in the Genus database with same CATH superfamily
5JFRA 1R5GA 4HXXA 4IF7A 4PNCA 4U1BA 1WY2A 1XGSA 2OKNA 1A16A 4RGZ1 4Z7MA 2GG8A 5JHUA 4U6ZA 2BHAA 2Q95A 3PKDA 2V6CA 1WKMA 2GG3A 2Q8KA 1C23A 4R60A 4S00A 1XGMA 1BOAA 1N51A 2Q93A 3FMQA 4S2TP 1M35A 5FCFA 2EVMA 3IU8A 4IDYA 1O0XA 4U73A 5D6FA 1CHMA 2ZSGA 3MR1A 2OAZA 2BWWA 1XGOA 3CB5A 4U70A 4FUKA 1KP0A 2EA2A 4RZYA 3CB6A 4FLJA 1BN5A 2BB7A 2GA2A 4FLKA 4FO7A 2BHBA 2BWVA 3BITA 2GGCA 3IU7A 3RORA 5CDEA 5CDLA 4A6WA 3BIPA 2EVCA 1QZYA 5CIKA 4MATA 2BWXA 3IU9A 1R5HA 2P99A 2Q92A 2GU5A 2P9AA 4IPAA 5D6EA 5CDVA 2BWYA 3TAVA 4U76A 2MATA 1C22A 4IKUA 1W2MA 1YW9A 2EVOA 2GU7A 3IG4A 3Q6DA 2DFIA 4JUQA 4S2RP 2GU6A 2G6PA 1XGNA 4KM3A 2GGBA 2GTXA 3CTZA 4ZWPA 3MX6A 3PKEA 3D27A 1WBQA 4QR8A 5CLSA 3L24A 1W7VA 4B28A 2BN7A 3S6BA 5FCHA 4U71A 2Q96A 4U75A 1C21A 1KQ0A 4U69A 1QXYA 4IKRA 3PKCA 4IECA 1WN1A 4U6WA 4U6EA 1B6AA 2B3KA 4RZZA 1YVMA 1B59A 2Q94A 2NQ6A 4U6CA 4EGEA 4A6VA 2BWUA 2IW2A 2HOWA 2V3XA 4ZNGA 2GG0A 4IKTA 3PKAA 2V3ZA 1WL9A 1JAWA 2BHDA 3MATA 2V3YA 1WLRA 3BIQA 4ZWOA 2GG7A 5CNXA 1YJ3A 2NQ7A 3PKBA 1C27A 2B3LA 1YW8A 1R58A 5JI6A 2ADUA 3TB5A 2GZ5A 4PV4A 1WL6A 3L7GA 2EA4A 2BWSA 4IU6A 1QXZA 2GG5A 4FO8A 2GU4A 2GG2A 2BWTA 1MATA 3FM3A 1QXWA 4FLIA 4FLLA 2BHCA 4OOKA 1Y1NA 2B3HA 4IKSA 5CE6A 2P98A 1C24A 3FMRA 4FKCA 5E5BA 1YW7A 3RVAA 4U6JA 2GG9A 4ZWUA 1XNZA 4S01A 1PV9A 2BH3A 1KQ9A
chains in the Genus database with same CATH topology
5JFRA 1R5GA 4HXXA 4IF7A 4PNCA 4U1BA 1WY2A 1XGSA 2OKNA 1A16A 4RGZ1 4Z7MA 2GG8A 5JHUA 4U6ZA 2BHAA 2Q95A 3PKDA 2V6CA 1WKMA 2GG3A 2Q8KA 1C23A 4R60A 4S00A 1XGMA 1BOAA 1N51A 2Q93A 3FMQA 4S2TP 1M35A 5FCFA 2EVMA 3IU8A 4IDYA 1O0XA 4U73A 5D6FA 1CHMA 2ZSGA 3MR1A 2OAZA 2BWWA 1XGOA 3CB5A 4U70A 4FUKA 1KP0A 2EA2A 4RZYA 3CB6A 4FLJA 1BN5A 2BB7A 2GA2A 4FLKA 4FO7A 2BHBA 2BWVA 3BITA 2GGCA 3IU7A 3RORA 5CDEA 5CDLA 4A6WA 3BIPA 2EVCA 1QZYA 5CIKA 4MATA 2BWXA 3IU9A 1R5HA 2P99A 2Q92A 2GU5A 2P9AA 4IPAA 5D6EA 5CDVA 2BWYA 3TAVA 4U76A 2MATA 1C22A 4IKUA 1W2MA 1YW9A 2EVOA 2GU7A 3IG4A 3Q6DA 2DFIA 4JUQA 4S2RP 2GU6A 2G6PA 1XGNA 4KM3A 2GGBA 2GTXA 3CTZA 4ZWPA 3MX6A 3PKEA 3D27A 1WBQA 4QR8A 5CLSA 3L24A 1W7VA 4B28A 2BN7A 3S6BA 5FCHA 4U71A 2Q96A 4U75A 1C21A 1KQ0A 4U69A 1QXYA 4IKRA 3PKCA 4IECA 1WN1A 4U6WA 4U6EA 1B6AA 2B3KA 4RZZA 1YVMA 1B59A 2Q94A 2NQ6A 4U6CA 4EGEA 4A6VA 2BWUA 2IW2A 2HOWA 2V3XA 4ZNGA 2GG0A 4IKTA 3PKAA 2V3ZA 1WL9A 1JAWA 2BHDA 3MATA 2V3YA 1WLRA 3BIQA 4ZWOA 2GG7A 5CNXA 1YJ3A 2NQ7A 3PKBA 1C27A 2B3LA 1YW8A 1R58A 5JI6A 2ADUA 3TB5A 2GZ5A 4PV4A 1WL6A 3L7GA 2EA4A 2BWSA 4IU6A 1QXZA 2GG5A 4FO8A 2GU4A 2GG2A 2BWTA 1MATA 3FM3A 1QXWA 4FLIA 4FLLA 2BHCA 4OOKA 1Y1NA 2B3HA 4IKSA 5CE6A 2P98A 1C24A 3FMRA 4FKCA 5E5BA 1YW7A 3RVAA 4U6JA 2GG9A 4ZWUA 1XNZA 4S01A 1PV9A 2BH3A 1KQ9A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 5JFR A;  1R5G A;  4HXX A;  4IF7 A;  4PNC A;  4U1B A;  1WY2 A;  1XGS A;  2OKN A;  1A16 A;  4RGZ 1;  4Z7M A;  2GG8 A;  5JHU A;  4U6Z A;  2BHA A;  2Q95 A;  3PKD A;  2V6C A;  1WKM A;  2GG3 A;  2Q8K A;  1C23 A;  4R60 A;  4S00 A;  1XGM A;  1BOA A;  1N51 A;  2Q93 A;  3FMQ A;  4S2T P;  1M35 A;  5FCF A;  2EVM A;  3IU8 A;  4IDY A;  1O0X A;  4U73 A;  5D6F A;  1CHM A;  2ZSG A;  3MR1 A;  2OAZ A;  2BWW A;  1XGO A;  3CB5 A;  4U70 A;  4FUK A;  1KP0 A;  2EA2 A;  4RZY A;  3CB6 A;  4FLJ A;  1BN5 A;  2BB7 A;  2GA2 A;  4FLK A;  4FO7 A;  2BHB A;  2BWV A;  3BIT A;  2GGC A;  3IU7 A;  3ROR A;  5CDE A;  5CDL A;  4A6W A;  3BIP A;  2EVC A;  1QZY A;  5CIK A;  4MAT A;  2BWX A;  3IU9 A;  1R5H A;  2P99 A;  2Q92 A;  2GU5 A;  2P9A A;  4IPA A;  5D6E A;  5CDV A;  2BWY A;  3TAV A;  4U76 A;  2MAT A;  1C22 A;  4IKU A;  1W2M A;  1YW9 A;  2EVO A;  2GU7 A;  3IG4 A;  3Q6D A;  2DFI A;  4JUQ A;  4S2R P;  2GU6 A;  2G6P A;  1XGN A;  4KM3 A;  2GGB A;  2GTX A;  3CTZ A;  4ZWP A;  3MX6 A;  3PKE A;  3D27 A;  1WBQ A;  4QR8 A;  5CLS A;  3L24 A;  1W7V A;  4B28 A;  2BN7 A;  3S6B A;  5FCH A;  4U71 A;  2Q96 A;  4U75 A;  1C21 A;  1KQ0 A;  4U69 A;  1QXY A;  4IKR A;  3PKC A;  4IEC A;  1WN1 A;  4U6W A;  4U6E A;  1B6A A;  2B3K A;  4RZZ A;  1YVM A;  1B59 A;  2Q94 A;  2NQ6 A;  4U6C A;  4EGE A;  4A6V A;  2BWU A;  2IW2 A;  2HOW A;  2V3X A;  4ZNG A;  2GG0 A;  4IKT A;  3PKA A;  2V3Z A;  1WL9 A;  1JAW A;  2BHD A;  3MAT A;  2V3Y A;  1WLR A;  3BIQ A;  4ZWO A;  2GG7 A;  5CNX A;  1YJ3 A;  2NQ7 A;  3PKB A;  1C27 A;  2B3L A;  1YW8 A;  1R58 A;  5JI6 A;  2ADU A;  3TB5 A;  2GZ5 A;  4PV4 A;  1WL6 A;  3L7G A;  2EA4 A;  2BWS A;  4IU6 A;  1QXZ A;  2GG5 A;  4FO8 A;  2GU4 A;  2GG2 A;  2BWT A;  1MAT A;  3FM3 A;  1QXW A;  4FLI A;  4FLL A;  2BHC A;  4OOK A;  1Y1N A;  2B3H A;  4IKS A;  5CE6 A;  2P98 A;  1C24 A;  3FMR A;  4FKC A;  5E5B A;  1YW7 A;  3RVA A;  4U6J A;  2GG9 A;  4ZWU A;  1XNZ A;  4S01 A;  1PV9 A;  2BH3 A;  1KQ9 A; 
#chains in the Genus database with same CATH topology
 5JFR A;  1R5G A;  4HXX A;  4IF7 A;  4PNC A;  4U1B A;  1WY2 A;  1XGS A;  2OKN A;  1A16 A;  4RGZ 1;  4Z7M A;  2GG8 A;  5JHU A;  4U6Z A;  2BHA A;  2Q95 A;  3PKD A;  2V6C A;  1WKM A;  2GG3 A;  2Q8K A;  1C23 A;  4R60 A;  4S00 A;  1XGM A;  1BOA A;  1N51 A;  2Q93 A;  3FMQ A;  4S2T P;  1M35 A;  5FCF A;  2EVM A;  3IU8 A;  4IDY A;  1O0X A;  4U73 A;  5D6F A;  1CHM A;  2ZSG A;  3MR1 A;  2OAZ A;  2BWW A;  1XGO A;  3CB5 A;  4U70 A;  4FUK A;  1KP0 A;  2EA2 A;  4RZY A;  3CB6 A;  4FLJ A;  1BN5 A;  2BB7 A;  2GA2 A;  4FLK A;  4FO7 A;  2BHB A;  2BWV A;  3BIT A;  2GGC A;  3IU7 A;  3ROR A;  5CDE A;  5CDL A;  4A6W A;  3BIP A;  2EVC A;  1QZY A;  5CIK A;  4MAT A;  2BWX A;  3IU9 A;  1R5H A;  2P99 A;  2Q92 A;  2GU5 A;  2P9A A;  4IPA A;  5D6E A;  5CDV A;  2BWY A;  3TAV A;  4U76 A;  2MAT A;  1C22 A;  4IKU A;  1W2M A;  1YW9 A;  2EVO A;  2GU7 A;  3IG4 A;  3Q6D A;  2DFI A;  4JUQ A;  4S2R P;  2GU6 A;  2G6P A;  1XGN A;  4KM3 A;  2GGB A;  2GTX A;  3CTZ A;  4ZWP A;  3MX6 A;  3PKE A;  3D27 A;  1WBQ A;  4QR8 A;  5CLS A;  3L24 A;  1W7V A;  4B28 A;  2BN7 A;  3S6B A;  5FCH A;  4U71 A;  2Q96 A;  4U75 A;  1C21 A;  1KQ0 A;  4U69 A;  1QXY A;  4IKR A;  3PKC A;  4IEC A;  1WN1 A;  4U6W A;  4U6E A;  1B6A A;  2B3K A;  4RZZ A;  1YVM A;  1B59 A;  2Q94 A;  2NQ6 A;  4U6C A;  4EGE A;  4A6V A;  2BWU A;  2IW2 A;  2HOW A;  2V3X A;  4ZNG A;  2GG0 A;  4IKT A;  3PKA A;  2V3Z A;  1WL9 A;  1JAW A;  2BHD A;  3MAT A;  2V3Y A;  1WLR A;  3BIQ A;  4ZWO A;  2GG7 A;  5CNX A;  1YJ3 A;  2NQ7 A;  3PKB A;  1C27 A;  2B3L A;  1YW8 A;  1R58 A;  5JI6 A;  2ADU A;  3TB5 A;  2GZ5 A;  4PV4 A;  1WL6 A;  3L7G A;  2EA4 A;  2BWS A;  4IU6 A;  1QXZ A;  2GG5 A;  4FO8 A;  2GU4 A;  2GG2 A;  2BWT A;  1MAT A;  3FM3 A;  1QXW A;  4FLI A;  4FLL A;  2BHC A;  4OOK A;  1Y1N A;  2B3H A;  4IKS A;  5CE6 A;  2P98 A;  1C24 A;  3FMR A;  4FKC A;  5E5B A;  1YW7 A;  3RVA A;  4U6J A;  2GG9 A;  4ZWU A;  1XNZ A;  4S01 A;  1PV9 A;  2BH3 A;  1KQ9 A; 
#chains in the Genus database with same CATH homology
 5JFR A;  1R5G A;  4HXX A;  4IF7 A;  4PNC A;  4U1B A;  1WY2 A;  1XGS A;  2OKN A;  1A16 A;  4RGZ 1;  4Z7M A;  2GG8 A;  5JHU A;  4U6Z A;  2BHA A;  2Q95 A;  3PKD A;  2V6C A;  1WKM A;  2GG3 A;  2Q8K A;  1C23 A;  4R60 A;  4S00 A;  1XGM A;  1BOA A;  1N51 A;  2Q93 A;  3FMQ A;  4S2T P;  1M35 A;  5FCF A;  2EVM A;  3IU8 A;  4IDY A;  1O0X A;  4U73 A;  5D6F A;  1CHM A;  2ZSG A;  3MR1 A;  2OAZ A;  2BWW A;  1XGO A;  3CB5 A;  4U70 A;  4FUK A;  1KP0 A;  2EA2 A;  4RZY A;  3CB6 A;  4FLJ A;  1BN5 A;  2BB7 A;  2GA2 A;  4FLK A;  4FO7 A;  2BHB A;  2BWV A;  3BIT A;  2GGC A;  3IU7 A;  3ROR A;  5CDE A;  5CDL A;  4A6W A;  3BIP A;  2EVC A;  1QZY A;  5CIK A;  4MAT A;  2BWX A;  3IU9 A;  1R5H A;  2P99 A;  2Q92 A;  2GU5 A;  2P9A A;  4IPA A;  5D6E A;  5CDV A;  2BWY A;  3TAV A;  4U76 A;  2MAT A;  1C22 A;  4IKU A;  1W2M A;  1YW9 A;  2EVO A;  2GU7 A;  3IG4 A;  3Q6D A;  2DFI A;  4JUQ A;  4S2R P;  2GU6 A;  2G6P A;  1XGN A;  4KM3 A;  2GGB A;  2GTX A;  3CTZ A;  4ZWP A;  3MX6 A;  3PKE A;  3D27 A;  1WBQ A;  4QR8 A;  5CLS A;  3L24 A;  1W7V A;  4B28 A;  2BN7 A;  3S6B A;  5FCH A;  4U71 A;  2Q96 A;  4U75 A;  1C21 A;  1KQ0 A;  4U69 A;  1QXY A;  4IKR A;  3PKC A;  4IEC A;  1WN1 A;  4U6W A;  4U6E A;  1B6A A;  2B3K A;  4RZZ A;  1YVM A;  1B59 A;  2Q94 A;  2NQ6 A;  4U6C A;  4EGE A;  4A6V A;  2BWU A;  2IW2 A;  2HOW A;  2V3X A;  4ZNG A;  2GG0 A;  4IKT A;  3PKA A;  2V3Z A;  1WL9 A;  1JAW A;  2BHD A;  3MAT A;  2V3Y A;  1WLR A;  3BIQ A;  4ZWO A;  2GG7 A;  5CNX A;  1YJ3 A;  2NQ7 A;  3PKB A;  1C27 A;  2B3L A;  1YW8 A;  1R58 A;  5JI6 A;  2ADU A;  3TB5 A;  2GZ5 A;  4PV4 A;  1WL6 A;  3L7G A;  2EA4 A;  2BWS A;  4IU6 A;  1QXZ A;  2GG5 A;  4FO8 A;  2GU4 A;  2GG2 A;  2BWT A;  1MAT A;  3FM3 A;  1QXW A;  4FLI A;  4FLL A;  2BHC A;  4OOK A;  1Y1N A;  2B3H A;  4IKS A;  5CE6 A;  2P98 A;  1C24 A;  3FMR A;  4FKC A;  5E5B A;  1YW7 A;  3RVA A;  4U6J A;  2GG9 A;  4ZWU A;  1XNZ A;  4S01 A;  1PV9 A;  2BH3 A;  1KQ9 A;
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite