3PKEA

M. tuberculosis metap with bengamide analog y10, in ni form
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
284
structure length
284
Chain Sequence
PSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Methionine aminopeptidase
total genus 88
structure length 284
sequence length 284
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2010-11-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3pkeA01
2P9AA 2EVOA 4PNCA 2Q92A 1R5GA 1WL6A 1B59A 2GU5A 2EA2A 1C27A 2EVMA 1B6AA 1R58A 4IECA 4IDYA 3RORA 2BWSA 5FCHA 4S01A 5CNXA 2GG7A 3RVAA 3TB5A 2GG8A 2B3LA 2P99A 2GU4A 1W7VA 2OKNA 5CDEA 5JFRA 1WBQA 3PKAA 3PKBA 4IF7A 5D6FA 4ZWPA 1YW9A 1WKMA 4FKCA 2GG2A 4U69A 4B28A 2GZ5A 2Q95A 1WLRA 1C24A 1WL9A 2BWTA 5JI6A 1KQ9A 2GA2A 2GGBA 4IKRA 4FO7A 2EA4A 4A6WA 4OOKA 2GG0A 5JHUA 2Q96A 3FMQA 2HOWA 2GG9A 3FM3A 3IU9A 2BN7A 4PV4A 3CTZA 2P98A 1YVMA 4HXXA 1M35A 2Q93A 3IU7A 4R60A 1WN1A 4RGZ1 4U76A 3IG4A 5D6EA 2OAZA 3MATA 3L24A 3MX6A 3D27A 1KP0A 1N51A 4IPAA 2BWXA 2BB7A 1C22A 4U6EA 2B3KA 1A16A 4U75A 3BIPA 2BWWA 2B3HA 3PKCA 1YJ3A 1BN5A 3PKDA 1BOAA 4U1BA 1XGOA 2DFIA 2EVCA 3TAVA 2IW2A 2GG3A 4Z7MA 2GTXA 1Y1NA 1XGSA 4IKUA 4A6VA 1YW8A 1XNZA 1YW7A 3FMRA 4EGEA 3IU8A 4IKTA 4U6CA 1C21A 2BWYA 1C23A 1QXWA 2NQ7A 1KQ0A 4FUKA 4JUQA 2V3YA 2MATA 1XGMA 3PKEA 2Q8KA 3CB6A 1QZYA 4FLIA 1O0XA 4FLJA 4ZWUA 1JAWA 2GU6A 3BITA 1WY2A 3S6BA 4U6WA 4QR8A 2V6CA 2BHAA 1MATA 2BWUA 3Q6DA 2ZSGA 4MATA 4U70A 1W2MA 4FO8A 1QXZA 4FLLA 1QXYA 2GGCA 4S2TP 2V3XA 5CIKA 5E5BA 1CHMA 3CB5A 3BIQA 2V3ZA 1XGNA 2BHCA 2BH3A 4U6ZA 2BHDA 4S2RP 2G6PA 2ADUA 4U6JA 5CLSA 4IKSA 2Q94A 5FCFA 4ZWOA 4U71A 3MR1A 2NQ6A 2BWVA 4IU6A 2GG5A 1R5HA 3L7GA 4KM3A 4ZNGA 5CDLA 5CE6A 4S00A 4RZYA 4FLKA 4RZZA 1PV9A 5CDVA 2GU7A 4U73A 2BHBA
chains in the Genus database with same CATH superfamily
2P9AA 2EVOA 4PNCA 2Q92A 1R5GA 1WL6A 1B59A 2GU5A 2EA2A 1C27A 2EVMA 1B6AA 1R58A 4IECA 4IDYA 3RORA 2BWSA 5FCHA 4S01A 5CNXA 2GG7A 3RVAA 3TB5A 2GG8A 2B3LA 2P99A 2GU4A 1W7VA 2OKNA 5CDEA 5JFRA 1WBQA 3PKAA 3PKBA 4IF7A 5D6FA 4ZWPA 1YW9A 1WKMA 4FKCA 2GG2A 4U69A 4B28A 2GZ5A 2Q95A 1WLRA 1C24A 1WL9A 2BWTA 5JI6A 1KQ9A 2GA2A 2GGBA 4IKRA 4FO7A 2EA4A 4A6WA 4OOKA 2GG0A 5JHUA 2Q96A 3FMQA 2HOWA 2GG9A 3FM3A 3IU9A 2BN7A 4PV4A 3CTZA 2P98A 1YVMA 4HXXA 1M35A 2Q93A 3IU7A 4R60A 1WN1A 4RGZ1 4U76A 3IG4A 5D6EA 2OAZA 3MATA 3L24A 3MX6A 3D27A 1KP0A 1N51A 4IPAA 2BWXA 2BB7A 1C22A 4U6EA 2B3KA 1A16A 4U75A 3BIPA 2BWWA 2B3HA 3PKCA 1YJ3A 1BN5A 3PKDA 1BOAA 4U1BA 1XGOA 2DFIA 2EVCA 3TAVA 2IW2A 2GG3A 4Z7MA 2GTXA 1Y1NA 1XGSA 4IKUA 4A6VA 1YW8A 1XNZA 1YW7A 3FMRA 4EGEA 3IU8A 4IKTA 4U6CA 1C21A 2BWYA 1C23A 1QXWA 2NQ7A 1KQ0A 4FUKA 4JUQA 2V3YA 2MATA 1XGMA 3PKEA 2Q8KA 3CB6A 1QZYA 4FLIA 1O0XA 4FLJA 4ZWUA 1JAWA 2GU6A 3BITA 1WY2A 3S6BA 4U6WA 4QR8A 2V6CA 2BHAA 1MATA 2BWUA 3Q6DA 2ZSGA 4MATA 4U70A 1W2MA 4FO8A 1QXZA 4FLLA 1QXYA 2GGCA 4S2TP 2V3XA 5CIKA 5E5BA 1CHMA 3CB5A 3BIQA 2V3ZA 1XGNA 2BHCA 2BH3A 4U6ZA 2BHDA 4S2RP 2G6PA 2ADUA 4U6JA 5CLSA 4IKSA 2Q94A 5FCFA 4ZWOA 4U71A 3MR1A 2NQ6A 2BWVA 4IU6A 2GG5A 1R5HA 3L7GA 4KM3A 4ZNGA 5CDLA 5CE6A 4S00A 4RZYA 4FLKA 4RZZA 1PV9A 5CDVA 2GU7A 4U73A 2BHBA
chains in the Genus database with same CATH topology
2P9AA 2EVOA 4PNCA 2Q92A 1R5GA 1WL6A 1B59A 2GU5A 2EA2A 1C27A 2EVMA 1B6AA 1R58A 4IECA 4IDYA 3RORA 2BWSA 5FCHA 4S01A 5CNXA 2GG7A 3RVAA 3TB5A 2GG8A 2B3LA 2P99A 2GU4A 1W7VA 2OKNA 5CDEA 5JFRA 1WBQA 3PKAA 3PKBA 4IF7A 5D6FA 4ZWPA 1YW9A 1WKMA 4FKCA 2GG2A 4U69A 4B28A 2GZ5A 2Q95A 1WLRA 1C24A 1WL9A 2BWTA 5JI6A 1KQ9A 2GA2A 2GGBA 4IKRA 4FO7A 2EA4A 4A6WA 4OOKA 2GG0A 5JHUA 2Q96A 3FMQA 2HOWA 2GG9A 3FM3A 3IU9A 2BN7A 4PV4A 3CTZA 2P98A 1YVMA 4HXXA 1M35A 2Q93A 3IU7A 4R60A 1WN1A 4RGZ1 4U76A 3IG4A 5D6EA 2OAZA 3MATA 3L24A 3MX6A 3D27A 1KP0A 1N51A 4IPAA 2BWXA 2BB7A 1C22A 4U6EA 2B3KA 1A16A 4U75A 3BIPA 2BWWA 2B3HA 3PKCA 1YJ3A 1BN5A 3PKDA 1BOAA 4U1BA 1XGOA 2DFIA 2EVCA 3TAVA 2IW2A 2GG3A 4Z7MA 2GTXA 1Y1NA 1XGSA 4IKUA 4A6VA 1YW8A 1XNZA 1YW7A 3FMRA 4EGEA 3IU8A 4IKTA 4U6CA 1C21A 2BWYA 1C23A 1QXWA 2NQ7A 1KQ0A 4FUKA 4JUQA 2V3YA 2MATA 1XGMA 3PKEA 2Q8KA 3CB6A 1QZYA 4FLIA 1O0XA 4FLJA 4ZWUA 1JAWA 2GU6A 3BITA 1WY2A 3S6BA 4U6WA 4QR8A 2V6CA 2BHAA 1MATA 2BWUA 3Q6DA 2ZSGA 4MATA 4U70A 1W2MA 4FO8A 1QXZA 4FLLA 1QXYA 2GGCA 4S2TP 2V3XA 5CIKA 5E5BA 1CHMA 3CB5A 3BIQA 2V3ZA 1XGNA 2BHCA 2BH3A 4U6ZA 2BHDA 4S2RP 2G6PA 2ADUA 4U6JA 5CLSA 4IKSA 2Q94A 5FCFA 4ZWOA 4U71A 3MR1A 2NQ6A 2BWVA 4IU6A 2GG5A 1R5HA 3L7GA 4KM3A 4ZNGA 5CDLA 5CE6A 4S00A 4RZYA 4FLKA 4RZZA 1PV9A 5CDVA 2GU7A 4U73A 2BHBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2P9A A;  2EVO A;  4PNC A;  2Q92 A;  1R5G A;  1WL6 A;  1B59 A;  2GU5 A;  2EA2 A;  1C27 A;  2EVM A;  1B6A A;  1R58 A;  4IEC A;  4IDY A;  3ROR A;  2BWS A;  5FCH A;  4S01 A;  5CNX A;  2GG7 A;  3RVA A;  3TB5 A;  2GG8 A;  2B3L A;  2P99 A;  2GU4 A;  1W7V A;  2OKN A;  5CDE A;  5JFR A;  1WBQ A;  3PKA A;  3PKB A;  4IF7 A;  5D6F A;  4ZWP A;  1YW9 A;  1WKM A;  4FKC A;  2GG2 A;  4U69 A;  4B28 A;  2GZ5 A;  2Q95 A;  1WLR A;  1C24 A;  1WL9 A;  2BWT A;  5JI6 A;  1KQ9 A;  2GA2 A;  2GGB A;  4IKR A;  4FO7 A;  2EA4 A;  4A6W A;  4OOK A;  2GG0 A;  5JHU A;  2Q96 A;  3FMQ A;  2HOW A;  2GG9 A;  3FM3 A;  3IU9 A;  2BN7 A;  4PV4 A;  3CTZ A;  2P98 A;  1YVM A;  4HXX A;  1M35 A;  2Q93 A;  3IU7 A;  4R60 A;  1WN1 A;  4RGZ 1;  4U76 A;  3IG4 A;  5D6E A;  2OAZ A;  3MAT A;  3L24 A;  3MX6 A;  3D27 A;  1KP0 A;  1N51 A;  4IPA A;  2BWX A;  2BB7 A;  1C22 A;  4U6E A;  2B3K A;  1A16 A;  4U75 A;  3BIP A;  2BWW A;  2B3H A;  3PKC A;  1YJ3 A;  1BN5 A;  3PKD A;  1BOA A;  4U1B A;  1XGO A;  2DFI A;  2EVC A;  3TAV A;  2IW2 A;  2GG3 A;  4Z7M A;  2GTX A;  1Y1N A;  1XGS A;  4IKU A;  4A6V A;  1YW8 A;  1XNZ A;  1YW7 A;  3FMR A;  4EGE A;  3IU8 A;  4IKT A;  4U6C A;  1C21 A;  2BWY A;  1C23 A;  1QXW A;  2NQ7 A;  1KQ0 A;  4FUK A;  4JUQ A;  2V3Y A;  2MAT A;  1XGM A;  3PKE A;  2Q8K A;  3CB6 A;  1QZY A;  4FLI A;  1O0X A;  4FLJ A;  4ZWU A;  1JAW A;  2GU6 A;  3BIT A;  1WY2 A;  3S6B A;  4U6W A;  4QR8 A;  2V6C A;  2BHA A;  1MAT A;  2BWU A;  3Q6D A;  2ZSG A;  4MAT A;  4U70 A;  1W2M A;  4FO8 A;  1QXZ A;  4FLL A;  1QXY A;  2GGC A;  4S2T P;  2V3X A;  5CIK A;  5E5B A;  1CHM A;  3CB5 A;  3BIQ A;  2V3Z A;  1XGN A;  2BHC A;  2BH3 A;  4U6Z A;  2BHD A;  4S2R P;  2G6P A;  2ADU A;  4U6J A;  5CLS A;  4IKS A;  2Q94 A;  5FCF A;  4ZWO A;  4U71 A;  3MR1 A;  2NQ6 A;  2BWV A;  4IU6 A;  2GG5 A;  1R5H A;  3L7G A;  4KM3 A;  4ZNG A;  5CDL A;  5CE6 A;  4S00 A;  4RZY A;  4FLK A;  4RZZ A;  1PV9 A;  5CDV A;  2GU7 A;  4U73 A;  2BHB A; 
#chains in the Genus database with same CATH topology
 2P9A A;  2EVO A;  4PNC A;  2Q92 A;  1R5G A;  1WL6 A;  1B59 A;  2GU5 A;  2EA2 A;  1C27 A;  2EVM A;  1B6A A;  1R58 A;  4IEC A;  4IDY A;  3ROR A;  2BWS A;  5FCH A;  4S01 A;  5CNX A;  2GG7 A;  3RVA A;  3TB5 A;  2GG8 A;  2B3L A;  2P99 A;  2GU4 A;  1W7V A;  2OKN A;  5CDE A;  5JFR A;  1WBQ A;  3PKA A;  3PKB A;  4IF7 A;  5D6F A;  4ZWP A;  1YW9 A;  1WKM A;  4FKC A;  2GG2 A;  4U69 A;  4B28 A;  2GZ5 A;  2Q95 A;  1WLR A;  1C24 A;  1WL9 A;  2BWT A;  5JI6 A;  1KQ9 A;  2GA2 A;  2GGB A;  4IKR A;  4FO7 A;  2EA4 A;  4A6W A;  4OOK A;  2GG0 A;  5JHU A;  2Q96 A;  3FMQ A;  2HOW A;  2GG9 A;  3FM3 A;  3IU9 A;  2BN7 A;  4PV4 A;  3CTZ A;  2P98 A;  1YVM A;  4HXX A;  1M35 A;  2Q93 A;  3IU7 A;  4R60 A;  1WN1 A;  4RGZ 1;  4U76 A;  3IG4 A;  5D6E A;  2OAZ A;  3MAT A;  3L24 A;  3MX6 A;  3D27 A;  1KP0 A;  1N51 A;  4IPA A;  2BWX A;  2BB7 A;  1C22 A;  4U6E A;  2B3K A;  1A16 A;  4U75 A;  3BIP A;  2BWW A;  2B3H A;  3PKC A;  1YJ3 A;  1BN5 A;  3PKD A;  1BOA A;  4U1B A;  1XGO A;  2DFI A;  2EVC A;  3TAV A;  2IW2 A;  2GG3 A;  4Z7M A;  2GTX A;  1Y1N A;  1XGS A;  4IKU A;  4A6V A;  1YW8 A;  1XNZ A;  1YW7 A;  3FMR A;  4EGE A;  3IU8 A;  4IKT A;  4U6C A;  1C21 A;  2BWY A;  1C23 A;  1QXW A;  2NQ7 A;  1KQ0 A;  4FUK A;  4JUQ A;  2V3Y A;  2MAT A;  1XGM A;  3PKE A;  2Q8K A;  3CB6 A;  1QZY A;  4FLI A;  1O0X A;  4FLJ A;  4ZWU A;  1JAW A;  2GU6 A;  3BIT A;  1WY2 A;  3S6B A;  4U6W A;  4QR8 A;  2V6C A;  2BHA A;  1MAT A;  2BWU A;  3Q6D A;  2ZSG A;  4MAT A;  4U70 A;  1W2M A;  4FO8 A;  1QXZ A;  4FLL A;  1QXY A;  2GGC A;  4S2T P;  2V3X A;  5CIK A;  5E5B A;  1CHM A;  3CB5 A;  3BIQ A;  2V3Z A;  1XGN A;  2BHC A;  2BH3 A;  4U6Z A;  2BHD A;  4S2R P;  2G6P A;  2ADU A;  4U6J A;  5CLS A;  4IKS A;  2Q94 A;  5FCF A;  4ZWO A;  4U71 A;  3MR1 A;  2NQ6 A;  2BWV A;  4IU6 A;  2GG5 A;  1R5H A;  3L7G A;  4KM3 A;  4ZNG A;  5CDL A;  5CE6 A;  4S00 A;  4RZY A;  4FLK A;  4RZZ A;  1PV9 A;  5CDV A;  2GU7 A;  4U73 A;  2BHB A; 
#chains in the Genus database with same CATH homology
 2P9A A;  2EVO A;  4PNC A;  2Q92 A;  1R5G A;  1WL6 A;  1B59 A;  2GU5 A;  2EA2 A;  1C27 A;  2EVM A;  1B6A A;  1R58 A;  4IEC A;  4IDY A;  3ROR A;  2BWS A;  5FCH A;  4S01 A;  5CNX A;  2GG7 A;  3RVA A;  3TB5 A;  2GG8 A;  2B3L A;  2P99 A;  2GU4 A;  1W7V A;  2OKN A;  5CDE A;  5JFR A;  1WBQ A;  3PKA A;  3PKB A;  4IF7 A;  5D6F A;  4ZWP A;  1YW9 A;  1WKM A;  4FKC A;  2GG2 A;  4U69 A;  4B28 A;  2GZ5 A;  2Q95 A;  1WLR A;  1C24 A;  1WL9 A;  2BWT A;  5JI6 A;  1KQ9 A;  2GA2 A;  2GGB A;  4IKR A;  4FO7 A;  2EA4 A;  4A6W A;  4OOK A;  2GG0 A;  5JHU A;  2Q96 A;  3FMQ A;  2HOW A;  2GG9 A;  3FM3 A;  3IU9 A;  2BN7 A;  4PV4 A;  3CTZ A;  2P98 A;  1YVM A;  4HXX A;  1M35 A;  2Q93 A;  3IU7 A;  4R60 A;  1WN1 A;  4RGZ 1;  4U76 A;  3IG4 A;  5D6E A;  2OAZ A;  3MAT A;  3L24 A;  3MX6 A;  3D27 A;  1KP0 A;  1N51 A;  4IPA A;  2BWX A;  2BB7 A;  1C22 A;  4U6E A;  2B3K A;  1A16 A;  4U75 A;  3BIP A;  2BWW A;  2B3H A;  3PKC A;  1YJ3 A;  1BN5 A;  3PKD A;  1BOA A;  4U1B A;  1XGO A;  2DFI A;  2EVC A;  3TAV A;  2IW2 A;  2GG3 A;  4Z7M A;  2GTX A;  1Y1N A;  1XGS A;  4IKU A;  4A6V A;  1YW8 A;  1XNZ A;  1YW7 A;  3FMR A;  4EGE A;  3IU8 A;  4IKT A;  4U6C A;  1C21 A;  2BWY A;  1C23 A;  1QXW A;  2NQ7 A;  1KQ0 A;  4FUK A;  4JUQ A;  2V3Y A;  2MAT A;  1XGM A;  3PKE A;  2Q8K A;  3CB6 A;  1QZY A;  4FLI A;  1O0X A;  4FLJ A;  4ZWU A;  1JAW A;  2GU6 A;  3BIT A;  1WY2 A;  3S6B A;  4U6W A;  4QR8 A;  2V6C A;  2BHA A;  1MAT A;  2BWU A;  3Q6D A;  2ZSG A;  4MAT A;  4U70 A;  1W2M A;  4FO8 A;  1QXZ A;  4FLL A;  1QXY A;  2GGC A;  4S2T P;  2V3X A;  5CIK A;  5E5B A;  1CHM A;  3CB5 A;  3BIQ A;  2V3Z A;  1XGN A;  2BHC A;  2BH3 A;  4U6Z A;  2BHD A;  4S2R P;  2G6P A;  2ADU A;  4U6J A;  5CLS A;  4IKS A;  2Q94 A;  5FCF A;  4ZWO A;  4U71 A;  3MR1 A;  2NQ6 A;  2BWV A;  4IU6 A;  2GG5 A;  1R5H A;  3L7G A;  4KM3 A;  4ZNG A;  5CDL A;  5CE6 A;  4S00 A;  4RZY A;  4FLK A;  4RZZ A;  1PV9 A;  5CDV A;  2GU7 A;  4U73 A;  2BHB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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