4EGEA

Crystal structure of dipeptidase pepe from mycobacterium ulcerans
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
371
structure length
371
Chain Sequence
GRFDTAVYARRLAAAAAATEQAGLAGLVITPGYDLRYLIGSRADTFERLTALVLPASGVPTIVLPRLELASLKESAASDLGVCVRDWVDGDDPYQLVAVALGGAPAATAVTDSMPALHLLPLADALGVLPVLATDVLRQLRMVKEAAEVDALAKAGAAIDRVHARVPAFLVPGRTEAQVAADIAEAIVAEGHSAVAFVIVGSGPHGADPHHGYSDRKLQVGDIVVVDIGGTYEPGYYSDSTRTYSIGDPSPDVAQQYSALQRAQRAAVDAVRPGVTAAQVDAAARDVLADAGLAEYFVHRTGHGIGLCVHEEPYIVAGNELPLVAGMAFSIEPGIYFPGRWGARIEDIVVVTENGALSVNNRPHELMVVPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Dipeptidase PepE
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium ulcerans
molecule tags Hydrolase
total genus 124
structure length 371
sequence length 371
ec nomenclature
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF01321 Creatinase_N Creatinase/Prolidase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4egeA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4egeA02
4IKTA 2Q95A 2EVMA 4FUKA 4U76A 2EA4A 3PKCA 2GZ5A 1XGMA 4FLLA 5E5BA 2V3ZA 5CE6A 2Q92A 4FLIA 1A16A 4U73A 4QR8A 3RVAA 3S6BA 3FMQA 1WBQA 1QXYA 1C27A 3PKAA 4RZYA 1YVMA 2GG8A 2GG9A 3Q6DA 2BWUA 3CTZA 1BOAA 1C21A 1PV9A 2Q96A 3IU9A 1QXZA 4IDYA 4FO8A 4FKCA 2B3LA 2NQ6A 4Z7MA 4A6VA 1WL6A 5CLSA 2BWVA 1R5HA 4IF7A 1O0XA 5D6FA 5FCFA 2NQ7A 4S00A 2P98A 2BB7A 1M35A 2EVOA 1WN1A 2BN7A 3OOOA 2Q8KA 4MATA 4U6ZA 1CHMA 4PV4A 2ZSGA 1C24A 2Q94A 3PKEA 3I7MA 1N51A 3PN9A 1R58A 4B28A 3MX6A 4PNCA 2G6PA 1W7VA 5CDLA 4IPAA 4JUQA 3L7GA 1QXWA 3BIPA 4S2RP 2GU7A 4FLKA 1BN5A 4EGEA 4FO7A 4FLJA 2BHBA 2OKNA 2GGBA 1WLRA 4U6CA 4U70A 3CB6A 4IKUA 2MATA 3FM3A 1R5GA 3IL0A 3QOCA 1W2MA 5CNXA 3IG4A 4S2TP 1C23A 2BWSA 5FCHA 3FMRA 4ZWOA 2EVCA 4U69A 4A6WA 2Q93A 1WKMA 2V3YA 2P99A 3RORA 1XGOA 3MATA 1B6AA 4U71A 2GG3A 2IW2A 4S01A 2HOWA 4U6JA 2GU5A 4U6EA 4ZWUA 3PKBA 3BITA 3CB5A 3O5VA 1C22A 3IU8A 4IKRA 5CDEA 2GG0A 2BH3A 2BWWA 1KQ9A 5D6EA 2BWXA 5CDVA 4RGZ1 2GA2A 2GTXA 4IU6A 2GU6A 1B59A 5JHUA 5E2CA 2GG2A 2GG5A 2ADUA 3MR1A 1Y1NA 1KQ0A 2GU4A 1QZYA 3TAVA 3D27A 3OVKA 3BIQA 3IU7A 4U75A 4ZNGA 2B3KA 1YW7A 4U6WA 2GGCA 1WL9A 2BWTA 3L24A 3PKDA 5JFRA 3TB5A 4ZWPA 4IKSA 5JI6A 2BHAA 4RZZA 2B3HA 1MATA 1YJ3A 4KM3A 2BHCA 3PEBA 4U1BA 5CIKA 2BHDA 1JAWA 2DFIA 4HXXA 1WY2A 2GG7A 1XGSA 2V3XA 4R60A 2EA2A 2OAZA 1YW9A 2P9AA 2V6CA 4IECA 1KP0A 1XGNA 1XNZA 1YW8A 2BWYA 4OOKA
chains in the Genus database with same CATH superfamily
4IKTA 2Q95A 2EVMA 4FUKA 4U76A 2EA4A 3PKCA 2GZ5A 1XGMA 4FLLA 5E5BA 2V3ZA 5CE6A 2Q92A 4FLIA 1A16A 4U73A 4QR8A 3RVAA 3S6BA 3FMQA 1WBQA 1QXYA 1C27A 3PKAA 4RZYA 1YVMA 2GG8A 2GG9A 3Q6DA 2BWUA 3CTZA 1BOAA 1C21A 1PV9A 2Q96A 3IU9A 1QXZA 4IDYA 4FO8A 4FKCA 2B3LA 2NQ6A 4Z7MA 4A6VA 1WL6A 5CLSA 2BWVA 1R5HA 4IF7A 1O0XA 5D6FA 5FCFA 2NQ7A 4S00A 2P98A 2BB7A 1M35A 2EVOA 1WN1A 2BN7A 3OOOA 2Q8KA 4MATA 4U6ZA 1CHMA 4PV4A 2ZSGA 1C24A 2Q94A 3PKEA 3I7MA 1N51A 3PN9A 1R58A 4B28A 3MX6A 4PNCA 2G6PA 1W7VA 5CDLA 4IPAA 4JUQA 3L7GA 1QXWA 3BIPA 4S2RP 2GU7A 4FLKA 1BN5A 4EGEA 4FO7A 4FLJA 2BHBA 2OKNA 2GGBA 1WLRA 4U6CA 4U70A 3CB6A 4IKUA 2MATA 3FM3A 1R5GA 3IL0A 3QOCA 1W2MA 5CNXA 3IG4A 4S2TP 1C23A 2BWSA 5FCHA 3FMRA 4ZWOA 2EVCA 4U69A 4A6WA 2Q93A 1WKMA 2V3YA 2P99A 3RORA 1XGOA 3MATA 1B6AA 4U71A 2GG3A 2IW2A 4S01A 2HOWA 4U6JA 2GU5A 4U6EA 4ZWUA 3PKBA 3BITA 3CB5A 3O5VA 1C22A 3IU8A 4IKRA 5CDEA 2GG0A 2BH3A 2BWWA 1KQ9A 5D6EA 2BWXA 5CDVA 4RGZ1 2GA2A 2GTXA 4IU6A 2GU6A 1B59A 5JHUA 5E2CA 2GG2A 2GG5A 2ADUA 3MR1A 1Y1NA 1KQ0A 2GU4A 1QZYA 3TAVA 3D27A 3OVKA 3BIQA 3IU7A 4U75A 4ZNGA 2B3KA 1YW7A 4U6WA 2GGCA 1WL9A 2BWTA 3L24A 3PKDA 5JFRA 3TB5A 4ZWPA 4IKSA 5JI6A 2BHAA 4RZZA 2B3HA 1MATA 1YJ3A 4KM3A 2BHCA 3PEBA 4U1BA 5CIKA 2BHDA 1JAWA 2DFIA 4HXXA 1WY2A 2GG7A 1XGSA 2V3XA 4R60A 2EA2A 2OAZA 1YW9A 2P9AA 2V6CA 4IECA 1KP0A 1XGNA 1XNZA 1YW8A 2BWYA 4OOKA
chains in the Genus database with same CATH topology
4IKTA 2Q95A 2EVMA 4FUKA 4U76A 2EA4A 3PKCA 2GZ5A 1XGMA 4FLLA 5E5BA 2V3ZA 5CE6A 2Q92A 4FLIA 1A16A 4U73A 4QR8A 3RVAA 3S6BA 3FMQA 1WBQA 1QXYA 1C27A 3PKAA 4RZYA 1YVMA 2GG8A 2GG9A 3Q6DA 2BWUA 3CTZA 1BOAA 1C21A 1PV9A 2Q96A 3IU9A 1QXZA 4IDYA 4FO8A 4FKCA 2B3LA 2NQ6A 4Z7MA 4A6VA 1WL6A 5CLSA 2BWVA 1R5HA 4IF7A 1O0XA 5D6FA 5FCFA 2NQ7A 4S00A 2P98A 2BB7A 1M35A 2EVOA 1WN1A 2BN7A 3OOOA 2Q8KA 4MATA 4U6ZA 1CHMA 4PV4A 2ZSGA 1C24A 2Q94A 3PKEA 3I7MA 1N51A 3PN9A 1R58A 4B28A 3MX6A 4PNCA 2G6PA 1W7VA 5CDLA 4IPAA 4JUQA 3L7GA 1QXWA 3BIPA 4S2RP 2GU7A 4FLKA 1BN5A 4EGEA 4FO7A 4FLJA 2BHBA 2OKNA 2GGBA 1WLRA 4U6CA 4U70A 3CB6A 4IKUA 2MATA 3FM3A 1R5GA 3IL0A 3QOCA 1W2MA 5CNXA 3IG4A 4S2TP 1C23A 2BWSA 5FCHA 3FMRA 4ZWOA 2EVCA 4U69A 4A6WA 2Q93A 1WKMA 2V3YA 2P99A 3RORA 1XGOA 3MATA 1B6AA 4U71A 2GG3A 2IW2A 4S01A 2HOWA 4U6JA 2GU5A 4U6EA 4ZWUA 3PKBA 3BITA 3CB5A 3O5VA 1C22A 3IU8A 4IKRA 5CDEA 2GG0A 2BH3A 2BWWA 1KQ9A 5D6EA 2BWXA 5CDVA 4RGZ1 2GA2A 2GTXA 4IU6A 2GU6A 1B59A 5JHUA 5E2CA 2GG2A 2GG5A 2ADUA 3MR1A 1Y1NA 1KQ0A 2GU4A 1QZYA 3TAVA 3D27A 3OVKA 3BIQA 3IU7A 4U75A 4ZNGA 2B3KA 1YW7A 4U6WA 2GGCA 1WL9A 2BWTA 3L24A 3PKDA 5JFRA 3TB5A 4ZWPA 4IKSA 5JI6A 2BHAA 4RZZA 2B3HA 1MATA 1YJ3A 4KM3A 2BHCA 3PEBA 4U1BA 5CIKA 2BHDA 1JAWA 2DFIA 4HXXA 1WY2A 2GG7A 1XGSA 2V3XA 4R60A 2EA2A 2OAZA 1YW9A 2P9AA 2V6CA 4IECA 1KP0A 1XGNA 1XNZA 1YW8A 2BWYA 4OOKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4IKT A;  2Q95 A;  2EVM A;  4FUK A;  4U76 A;  2EA4 A;  3PKC A;  2GZ5 A;  1XGM A;  4FLL A;  5E5B A;  2V3Z A;  5CE6 A;  2Q92 A;  4FLI A;  1A16 A;  4U73 A;  4QR8 A;  3RVA A;  3S6B A;  3FMQ A;  1WBQ A;  1QXY A;  1C27 A;  3PKA A;  4RZY A;  1YVM A;  2GG8 A;  2GG9 A;  3Q6D A;  2BWU A;  3CTZ A;  1BOA A;  1C21 A;  1PV9 A;  2Q96 A;  3IU9 A;  1QXZ A;  4IDY A;  4FO8 A;  4FKC A;  2B3L A;  2NQ6 A;  4Z7M A;  4A6V A;  1WL6 A;  5CLS A;  2BWV A;  1R5H A;  4IF7 A;  1O0X A;  5D6F A;  5FCF A;  2NQ7 A;  4S00 A;  2P98 A;  2BB7 A;  1M35 A;  2EVO A;  1WN1 A;  2BN7 A;  3OOO A;  2Q8K A;  4MAT A;  4U6Z A;  1CHM A;  4PV4 A;  2ZSG A;  1C24 A;  2Q94 A;  3PKE A;  3I7M A;  1N51 A;  3PN9 A;  1R58 A;  4B28 A;  3MX6 A;  4PNC A;  2G6P A;  1W7V A;  5CDL A;  4IPA A;  4JUQ A;  3L7G A;  1QXW A;  3BIP A;  4S2R P;  2GU7 A;  4FLK A;  1BN5 A;  4EGE A;  4FO7 A;  4FLJ A;  2BHB A;  2OKN A;  2GGB A;  1WLR A;  4U6C A;  4U70 A;  3CB6 A;  4IKU A;  2MAT A;  3FM3 A;  1R5G A;  3IL0 A;  3QOC A;  1W2M A;  5CNX A;  3IG4 A;  4S2T P;  1C23 A;  2BWS A;  5FCH A;  3FMR A;  4ZWO A;  2EVC A;  4U69 A;  4A6W A;  2Q93 A;  1WKM A;  2V3Y A;  2P99 A;  3ROR A;  1XGO A;  3MAT A;  1B6A A;  4U71 A;  2GG3 A;  2IW2 A;  4S01 A;  2HOW A;  4U6J A;  2GU5 A;  4U6E A;  4ZWU A;  3PKB A;  3BIT A;  3CB5 A;  3O5V A;  1C22 A;  3IU8 A;  4IKR A;  5CDE A;  2GG0 A;  2BH3 A;  2BWW A;  1KQ9 A;  5D6E A;  2BWX A;  5CDV A;  4RGZ 1;  2GA2 A;  2GTX A;  4IU6 A;  2GU6 A;  1B59 A;  5JHU A;  5E2C A;  2GG2 A;  2GG5 A;  2ADU A;  3MR1 A;  1Y1N A;  1KQ0 A;  2GU4 A;  1QZY A;  3TAV A;  3D27 A;  3OVK A;  3BIQ A;  3IU7 A;  4U75 A;  4ZNG A;  2B3K A;  1YW7 A;  4U6W A;  2GGC A;  1WL9 A;  2BWT A;  3L24 A;  3PKD A;  5JFR A;  3TB5 A;  4ZWP A;  4IKS A;  5JI6 A;  2BHA A;  4RZZ A;  2B3H A;  1MAT A;  1YJ3 A;  4KM3 A;  2BHC A;  3PEB A;  4U1B A;  5CIK A;  2BHD A;  1JAW A;  2DFI A;  4HXX A;  1WY2 A;  2GG7 A;  1XGS A;  2V3X A;  4R60 A;  2EA2 A;  2OAZ A;  1YW9 A;  2P9A A;  2V6C A;  4IEC A;  1KP0 A;  1XGN A;  1XNZ A;  1YW8 A;  2BWY A;  4OOK A; 
#chains in the Genus database with same CATH topology
 4IKT A;  2Q95 A;  2EVM A;  4FUK A;  4U76 A;  2EA4 A;  3PKC A;  2GZ5 A;  1XGM A;  4FLL A;  5E5B A;  2V3Z A;  5CE6 A;  2Q92 A;  4FLI A;  1A16 A;  4U73 A;  4QR8 A;  3RVA A;  3S6B A;  3FMQ A;  1WBQ A;  1QXY A;  1C27 A;  3PKA A;  4RZY A;  1YVM A;  2GG8 A;  2GG9 A;  3Q6D A;  2BWU A;  3CTZ A;  1BOA A;  1C21 A;  1PV9 A;  2Q96 A;  3IU9 A;  1QXZ A;  4IDY A;  4FO8 A;  4FKC A;  2B3L A;  2NQ6 A;  4Z7M A;  4A6V A;  1WL6 A;  5CLS A;  2BWV A;  1R5H A;  4IF7 A;  1O0X A;  5D6F A;  5FCF A;  2NQ7 A;  4S00 A;  2P98 A;  2BB7 A;  1M35 A;  2EVO A;  1WN1 A;  2BN7 A;  3OOO A;  2Q8K A;  4MAT A;  4U6Z A;  1CHM A;  4PV4 A;  2ZSG A;  1C24 A;  2Q94 A;  3PKE A;  3I7M A;  1N51 A;  3PN9 A;  1R58 A;  4B28 A;  3MX6 A;  4PNC A;  2G6P A;  1W7V A;  5CDL A;  4IPA A;  4JUQ A;  3L7G A;  1QXW A;  3BIP A;  4S2R P;  2GU7 A;  4FLK A;  1BN5 A;  4EGE A;  4FO7 A;  4FLJ A;  2BHB A;  2OKN A;  2GGB A;  1WLR A;  4U6C A;  4U70 A;  3CB6 A;  4IKU A;  2MAT A;  3FM3 A;  1R5G A;  3IL0 A;  3QOC A;  1W2M A;  5CNX A;  3IG4 A;  4S2T P;  1C23 A;  2BWS A;  5FCH A;  3FMR A;  4ZWO A;  2EVC A;  4U69 A;  4A6W A;  2Q93 A;  1WKM A;  2V3Y A;  2P99 A;  3ROR A;  1XGO A;  3MAT A;  1B6A A;  4U71 A;  2GG3 A;  2IW2 A;  4S01 A;  2HOW A;  4U6J A;  2GU5 A;  4U6E A;  4ZWU A;  3PKB A;  3BIT A;  3CB5 A;  3O5V A;  1C22 A;  3IU8 A;  4IKR A;  5CDE A;  2GG0 A;  2BH3 A;  2BWW A;  1KQ9 A;  5D6E A;  2BWX A;  5CDV A;  4RGZ 1;  2GA2 A;  2GTX A;  4IU6 A;  2GU6 A;  1B59 A;  5JHU A;  5E2C A;  2GG2 A;  2GG5 A;  2ADU A;  3MR1 A;  1Y1N A;  1KQ0 A;  2GU4 A;  1QZY A;  3TAV A;  3D27 A;  3OVK A;  3BIQ A;  3IU7 A;  4U75 A;  4ZNG A;  2B3K A;  1YW7 A;  4U6W A;  2GGC A;  1WL9 A;  2BWT A;  3L24 A;  3PKD A;  5JFR A;  3TB5 A;  4ZWP A;  4IKS A;  5JI6 A;  2BHA A;  4RZZ A;  2B3H A;  1MAT A;  1YJ3 A;  4KM3 A;  2BHC A;  3PEB A;  4U1B A;  5CIK A;  2BHD A;  1JAW A;  2DFI A;  4HXX A;  1WY2 A;  2GG7 A;  1XGS A;  2V3X A;  4R60 A;  2EA2 A;  2OAZ A;  1YW9 A;  2P9A A;  2V6C A;  4IEC A;  1KP0 A;  1XGN A;  1XNZ A;  1YW8 A;  2BWY A;  4OOK A; 
#chains in the Genus database with same CATH homology
 4IKT A;  2Q95 A;  2EVM A;  4FUK A;  4U76 A;  2EA4 A;  3PKC A;  2GZ5 A;  1XGM A;  4FLL A;  5E5B A;  2V3Z A;  5CE6 A;  2Q92 A;  4FLI A;  1A16 A;  4U73 A;  4QR8 A;  3RVA A;  3S6B A;  3FMQ A;  1WBQ A;  1QXY A;  1C27 A;  3PKA A;  4RZY A;  1YVM A;  2GG8 A;  2GG9 A;  3Q6D A;  2BWU A;  3CTZ A;  1BOA A;  1C21 A;  1PV9 A;  2Q96 A;  3IU9 A;  1QXZ A;  4IDY A;  4FO8 A;  4FKC A;  2B3L A;  2NQ6 A;  4Z7M A;  4A6V A;  1WL6 A;  5CLS A;  2BWV A;  1R5H A;  4IF7 A;  1O0X A;  5D6F A;  5FCF A;  2NQ7 A;  4S00 A;  2P98 A;  2BB7 A;  1M35 A;  2EVO A;  1WN1 A;  2BN7 A;  3OOO A;  2Q8K A;  4MAT A;  4U6Z A;  1CHM A;  4PV4 A;  2ZSG A;  1C24 A;  2Q94 A;  3PKE A;  3I7M A;  1N51 A;  3PN9 A;  1R58 A;  4B28 A;  3MX6 A;  4PNC A;  2G6P A;  1W7V A;  5CDL A;  4IPA A;  4JUQ A;  3L7G A;  1QXW A;  3BIP A;  4S2R P;  2GU7 A;  4FLK A;  1BN5 A;  4EGE A;  4FO7 A;  4FLJ A;  2BHB A;  2OKN A;  2GGB A;  1WLR A;  4U6C A;  4U70 A;  3CB6 A;  4IKU A;  2MAT A;  3FM3 A;  1R5G A;  3IL0 A;  3QOC A;  1W2M A;  5CNX A;  3IG4 A;  4S2T P;  1C23 A;  2BWS A;  5FCH A;  3FMR A;  4ZWO A;  2EVC A;  4U69 A;  4A6W A;  2Q93 A;  1WKM A;  2V3Y A;  2P99 A;  3ROR A;  1XGO A;  3MAT A;  1B6A A;  4U71 A;  2GG3 A;  2IW2 A;  4S01 A;  2HOW A;  4U6J A;  2GU5 A;  4U6E A;  4ZWU A;  3PKB A;  3BIT A;  3CB5 A;  3O5V A;  1C22 A;  3IU8 A;  4IKR A;  5CDE A;  2GG0 A;  2BH3 A;  2BWW A;  1KQ9 A;  5D6E A;  2BWX A;  5CDV A;  4RGZ 1;  2GA2 A;  2GTX A;  4IU6 A;  2GU6 A;  1B59 A;  5JHU A;  5E2C A;  2GG2 A;  2GG5 A;  2ADU A;  3MR1 A;  1Y1N A;  1KQ0 A;  2GU4 A;  1QZY A;  3TAV A;  3D27 A;  3OVK A;  3BIQ A;  3IU7 A;  4U75 A;  4ZNG A;  2B3K A;  1YW7 A;  4U6W A;  2GGC A;  1WL9 A;  2BWT A;  3L24 A;  3PKD A;  5JFR A;  3TB5 A;  4ZWP A;  4IKS A;  5JI6 A;  2BHA A;  4RZZ A;  2B3H A;  1MAT A;  1YJ3 A;  4KM3 A;  2BHC A;  3PEB A;  4U1B A;  5CIK A;  2BHD A;  1JAW A;  2DFI A;  4HXX A;  1WY2 A;  2GG7 A;  1XGS A;  2V3X A;  4R60 A;  2EA2 A;  2OAZ A;  1YW9 A;  2P9A A;  2V6C A;  4IEC A;  1KP0 A;  1XGN A;  1XNZ A;  1YW8 A;  2BWY A;  4OOK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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