4EGEA

Crystal structure of dipeptidase pepe from mycobacterium ulcerans
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
371
structure length
371
Chain Sequence
b'GRFDTAVYARRLAAAAAATEQAGLAGLVITPGYDLRYLIGSRADTFERLTALVLPASGVPTIVLPRLELASLKESAASDLGVCVRDWVDGDDPYQLVAVALGGAPAATAVTDSMPALHLLPLADALGVLPVLATDVLRQLRMVKEAAEVDALAKAGAAIDRVHARVPAFLVPGRTEAQVAADIAEAIVAEGHSAVAFVIVGSGPHGADPHHGYSDRKLQVGDIVVVDIGGTYEPGYYSDSTRTYSIGDPSPDVAQQYSALQRAQRAAVDAVRPGVTAAQVDAAARDVLADAGLAEYFVHRTGHGIGLCVHEEPYIVAGNELPLVAGMAFSIEPGIYFPGRWGARIEDIVVVTENGALSVNNRPHELMVVPV'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Dipeptidase PepE
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium ulcerans
molecule tags Hydrolase
total genus 124
structure length 371
sequence length 371
ec nomenclature
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF01321 Creatinase_N Creatinase/Prolidase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4egeA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4egeA02
2GG9A 4S2RP 2V3XA 2EVMA 4OOKA 2GG5A 4RZYA 3CB5A 3IL0A 2G6PA 4IU6A 2P9AA 1O0XA 3MATA 4FO7A 1B6AA 1WBQA 3O5VA 2GG2A 3PN9A 3PKDA 4U6CA 1W7VA 1BOAA 5CLSA 5CDEA 5D6EA 3L7GA 1XNZA 5E2CA 3IU8A 3PKBA 4IPAA 4U75A 3FM3A 2BH3A 2BWXA 1XGNA 4PV4A 4IKUA 5JHUA 5JFRA 3CB6A 4B28A 3IU9A 2BB7A 4U6JA 2GU4A 4Z7MA 1QXZA 1YW7A 1Y1NA 1R5HA 2Q92A 4IECA 3FMQA 4A6VA 2P98A 2P99A 1WL6A 4ZWPA 2GG8A 2B3LA 2BWSA 3QOCA 4KM3A 4JUQA 2V6CA 2EVCA 2EVOA 1M35A 1R58A 5CDLA 3BIPA 1R5GA 4FLIA 4U71A 3TAVA 2EA2A 1KP0A 2GU7A 4S00A 3PKAA 1WLRA 1WN1A 4A6WA 1YJ3A 1JAWA 1N51A 3IG4A 3L24A 4S01A 1WKMA 3FMRA 2OAZA 1A16A 1BN5A 5CE6A 1XGOA 3S6BA 2GTXA 5JI6A 3MR1A 1WY2A 2B3HA 3MX6A 1YW8A 2GU6A 3CTZA 4FKCA 1YVMA 4EGEA 2GG7A 4FUKA 2BWYA 4FLKA 3BIQA 4RZZA 1KQ0A 4U6ZA 5CIKA 5CNXA 1WL9A 1C24A 2BWVA 3OVKA 1XGSA 2EA4A 2MATA 1B59A 3TB5A 3PKEA 4U6EA 2BWUA 3RVAA 1QZYA 2GZ5A 4R60A 5E5BA 4U69A 1PV9A 4U76A 4U6WA 4QR8A 2GU5A 4ZWOA 1C22A 2Q93A 4FLJA 2NQ7A 2BHCA 2Q96A 5CDVA 2IW2A 1MATA 1XGMA 2Q8KA 3PKCA 4IKTA 2ZSGA 3IU7A 1CHMA 3OOOA 1KQ9A 1YW9A 4IKRA 2ADUA 2BHDA 2HOWA 2BN7A 4U1BA 2BHAA 4ZNGA 4S2TP 2GG3A 4MATA 4HXXA 2V3ZA 3I7MA 3PEBA 3D27A 2V3YA 2DFIA 2NQ6A 2Q95A 4ZWUA 4U70A 1W2MA 2B3KA 1QXWA 2GGBA 2BWTA 4U73A 4FO8A 5FCHA 2GA2A 2GGCA 2OKNA 5D6FA 4RGZ1 1QXYA 3RORA 2Q94A 3Q6DA 4IF7A 4IDYA 4IKSA 1C27A 2GG0A 4FLLA 4PNCA 1C23A 2BWWA 3BITA 5FCFA 2BHBA 1C21A
chains in the Genus database with same CATH superfamily
2GG9A 4S2RP 2V3XA 2EVMA 4OOKA 2GG5A 4RZYA 3CB5A 3IL0A 2G6PA 4IU6A 2P9AA 1O0XA 3MATA 4FO7A 1B6AA 1WBQA 3O5VA 2GG2A 3PN9A 3PKDA 4U6CA 1W7VA 1BOAA 5CLSA 5CDEA 5D6EA 3L7GA 1XNZA 5E2CA 3IU8A 3PKBA 4IPAA 4U75A 3FM3A 2BH3A 2BWXA 1XGNA 4PV4A 4IKUA 5JHUA 5JFRA 3CB6A 4B28A 3IU9A 2BB7A 4U6JA 2GU4A 4Z7MA 1QXZA 1YW7A 1Y1NA 1R5HA 2Q92A 4IECA 3FMQA 4A6VA 2P98A 2P99A 1WL6A 4ZWPA 2GG8A 2B3LA 2BWSA 3QOCA 4KM3A 4JUQA 2V6CA 2EVCA 2EVOA 1M35A 1R58A 5CDLA 3BIPA 1R5GA 4FLIA 4U71A 3TAVA 2EA2A 1KP0A 2GU7A 4S00A 3PKAA 1WLRA 1WN1A 4A6WA 1YJ3A 1JAWA 1N51A 3IG4A 3L24A 4S01A 1WKMA 3FMRA 2OAZA 1A16A 1BN5A 5CE6A 1XGOA 3S6BA 2GTXA 5JI6A 3MR1A 1WY2A 2B3HA 3MX6A 1YW8A 2GU6A 3CTZA 4FKCA 1YVMA 4EGEA 2GG7A 4FUKA 2BWYA 4FLKA 3BIQA 4RZZA 1KQ0A 4U6ZA 5CIKA 5CNXA 1WL9A 1C24A 2BWVA 3OVKA 1XGSA 2EA4A 2MATA 1B59A 3TB5A 3PKEA 4U6EA 2BWUA 3RVAA 1QZYA 2GZ5A 4R60A 5E5BA 4U69A 1PV9A 4U76A 4U6WA 4QR8A 2GU5A 4ZWOA 1C22A 2Q93A 4FLJA 2NQ7A 2BHCA 2Q96A 5CDVA 2IW2A 1MATA 1XGMA 2Q8KA 3PKCA 4IKTA 2ZSGA 3IU7A 1CHMA 3OOOA 1KQ9A 1YW9A 4IKRA 2ADUA 2BHDA 2HOWA 2BN7A 4U1BA 2BHAA 4ZNGA 4S2TP 2GG3A 4MATA 4HXXA 2V3ZA 3I7MA 3PEBA 3D27A 2V3YA 2DFIA 2NQ6A 2Q95A 4ZWUA 4U70A 1W2MA 2B3KA 1QXWA 2GGBA 2BWTA 4U73A 4FO8A 5FCHA 2GA2A 2GGCA 2OKNA 5D6FA 4RGZ1 1QXYA 3RORA 2Q94A 3Q6DA 4IF7A 4IDYA 4IKSA 1C27A 2GG0A 4FLLA 4PNCA 1C23A 2BWWA 3BITA 5FCFA 2BHBA 1C21A
chains in the Genus database with same CATH topology
2GG9A 4S2RP 2V3XA 2EVMA 4OOKA 2GG5A 4RZYA 3CB5A 3IL0A 2G6PA 4IU6A 2P9AA 1O0XA 3MATA 4FO7A 1B6AA 1WBQA 3O5VA 2GG2A 3PN9A 3PKDA 4U6CA 1W7VA 1BOAA 5CLSA 5CDEA 5D6EA 3L7GA 1XNZA 5E2CA 3IU8A 3PKBA 4IPAA 4U75A 3FM3A 2BH3A 2BWXA 1XGNA 4PV4A 4IKUA 5JHUA 5JFRA 3CB6A 4B28A 3IU9A 2BB7A 4U6JA 2GU4A 4Z7MA 1QXZA 1YW7A 1Y1NA 1R5HA 2Q92A 4IECA 3FMQA 4A6VA 2P98A 2P99A 1WL6A 4ZWPA 2GG8A 2B3LA 2BWSA 3QOCA 4KM3A 4JUQA 2V6CA 2EVCA 2EVOA 1M35A 1R58A 5CDLA 3BIPA 1R5GA 4FLIA 4U71A 3TAVA 2EA2A 1KP0A 2GU7A 4S00A 3PKAA 1WLRA 1WN1A 4A6WA 1YJ3A 1JAWA 1N51A 3IG4A 3L24A 4S01A 1WKMA 3FMRA 2OAZA 1A16A 1BN5A 5CE6A 1XGOA 3S6BA 2GTXA 5JI6A 3MR1A 1WY2A 2B3HA 3MX6A 1YW8A 2GU6A 3CTZA 4FKCA 1YVMA 4EGEA 2GG7A 4FUKA 2BWYA 4FLKA 3BIQA 4RZZA 1KQ0A 4U6ZA 5CIKA 5CNXA 1WL9A 1C24A 2BWVA 3OVKA 1XGSA 2EA4A 2MATA 1B59A 3TB5A 3PKEA 4U6EA 2BWUA 3RVAA 1QZYA 2GZ5A 4R60A 5E5BA 4U69A 1PV9A 4U76A 4U6WA 4QR8A 2GU5A 4ZWOA 1C22A 2Q93A 4FLJA 2NQ7A 2BHCA 2Q96A 5CDVA 2IW2A 1MATA 1XGMA 2Q8KA 3PKCA 4IKTA 2ZSGA 3IU7A 1CHMA 3OOOA 1KQ9A 1YW9A 4IKRA 2ADUA 2BHDA 2HOWA 2BN7A 4U1BA 2BHAA 4ZNGA 4S2TP 2GG3A 4MATA 4HXXA 2V3ZA 3I7MA 3PEBA 3D27A 2V3YA 2DFIA 2NQ6A 2Q95A 4ZWUA 4U70A 1W2MA 2B3KA 1QXWA 2GGBA 2BWTA 4U73A 4FO8A 5FCHA 2GA2A 2GGCA 2OKNA 5D6FA 4RGZ1 1QXYA 3RORA 2Q94A 3Q6DA 4IF7A 4IDYA 4IKSA 1C27A 2GG0A 4FLLA 4PNCA 1C23A 2BWWA 3BITA 5FCFA 2BHBA 1C21A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GG9 A;  4S2R P;  2V3X A;  2EVM A;  4OOK A;  2GG5 A;  4RZY A;  3CB5 A;  3IL0 A;  2G6P A;  4IU6 A;  2P9A A;  1O0X A;  3MAT A;  4FO7 A;  1B6A A;  1WBQ A;  3O5V A;  2GG2 A;  3PN9 A;  3PKD A;  4U6C A;  1W7V A;  1BOA A;  5CLS A;  5CDE A;  5D6E A;  3L7G A;  1XNZ A;  5E2C A;  3IU8 A;  3PKB A;  4IPA A;  4U75 A;  3FM3 A;  2BH3 A;  2BWX A;  1XGN A;  4PV4 A;  4IKU A;  5JHU A;  5JFR A;  3CB6 A;  4B28 A;  3IU9 A;  2BB7 A;  4U6J A;  2GU4 A;  4Z7M A;  1QXZ A;  1YW7 A;  1Y1N A;  1R5H A;  2Q92 A;  4IEC A;  3FMQ A;  4A6V A;  2P98 A;  2P99 A;  1WL6 A;  4ZWP A;  2GG8 A;  2B3L A;  2BWS A;  3QOC A;  4KM3 A;  4JUQ A;  2V6C A;  2EVC A;  2EVO A;  1M35 A;  1R58 A;  5CDL A;  3BIP A;  1R5G A;  4FLI A;  4U71 A;  3TAV A;  2EA2 A;  1KP0 A;  2GU7 A;  4S00 A;  3PKA A;  1WLR A;  1WN1 A;  4A6W A;  1YJ3 A;  1JAW A;  1N51 A;  3IG4 A;  3L24 A;  4S01 A;  1WKM A;  3FMR A;  2OAZ A;  1A16 A;  1BN5 A;  5CE6 A;  1XGO A;  3S6B A;  2GTX A;  5JI6 A;  3MR1 A;  1WY2 A;  2B3H A;  3MX6 A;  1YW8 A;  2GU6 A;  3CTZ A;  4FKC A;  1YVM A;  4EGE A;  2GG7 A;  4FUK A;  2BWY A;  4FLK A;  3BIQ A;  4RZZ A;  1KQ0 A;  4U6Z A;  5CIK A;  5CNX A;  1WL9 A;  1C24 A;  2BWV A;  3OVK A;  1XGS A;  2EA4 A;  2MAT A;  1B59 A;  3TB5 A;  3PKE A;  4U6E A;  2BWU A;  3RVA A;  1QZY A;  2GZ5 A;  4R60 A;  5E5B A;  4U69 A;  1PV9 A;  4U76 A;  4U6W A;  4QR8 A;  2GU5 A;  4ZWO A;  1C22 A;  2Q93 A;  4FLJ A;  2NQ7 A;  2BHC A;  2Q96 A;  5CDV A;  2IW2 A;  1MAT A;  1XGM A;  2Q8K A;  3PKC A;  4IKT A;  2ZSG A;  3IU7 A;  1CHM A;  3OOO A;  1KQ9 A;  1YW9 A;  4IKR A;  2ADU A;  2BHD A;  2HOW A;  2BN7 A;  4U1B A;  2BHA A;  4ZNG A;  4S2T P;  2GG3 A;  4MAT A;  4HXX A;  2V3Z A;  3I7M A;  3PEB A;  3D27 A;  2V3Y A;  2DFI A;  2NQ6 A;  2Q95 A;  4ZWU A;  4U70 A;  1W2M A;  2B3K A;  1QXW A;  2GGB A;  2BWT A;  4U73 A;  4FO8 A;  5FCH A;  2GA2 A;  2GGC A;  2OKN A;  5D6F A;  4RGZ 1;  1QXY A;  3ROR A;  2Q94 A;  3Q6D A;  4IF7 A;  4IDY A;  4IKS A;  1C27 A;  2GG0 A;  4FLL A;  4PNC A;  1C23 A;  2BWW A;  3BIT A;  5FCF A;  2BHB A;  1C21 A; 
#chains in the Genus database with same CATH topology
 2GG9 A;  4S2R P;  2V3X A;  2EVM A;  4OOK A;  2GG5 A;  4RZY A;  3CB5 A;  3IL0 A;  2G6P A;  4IU6 A;  2P9A A;  1O0X A;  3MAT A;  4FO7 A;  1B6A A;  1WBQ A;  3O5V A;  2GG2 A;  3PN9 A;  3PKD A;  4U6C A;  1W7V A;  1BOA A;  5CLS A;  5CDE A;  5D6E A;  3L7G A;  1XNZ A;  5E2C A;  3IU8 A;  3PKB A;  4IPA A;  4U75 A;  3FM3 A;  2BH3 A;  2BWX A;  1XGN A;  4PV4 A;  4IKU A;  5JHU A;  5JFR A;  3CB6 A;  4B28 A;  3IU9 A;  2BB7 A;  4U6J A;  2GU4 A;  4Z7M A;  1QXZ A;  1YW7 A;  1Y1N A;  1R5H A;  2Q92 A;  4IEC A;  3FMQ A;  4A6V A;  2P98 A;  2P99 A;  1WL6 A;  4ZWP A;  2GG8 A;  2B3L A;  2BWS A;  3QOC A;  4KM3 A;  4JUQ A;  2V6C A;  2EVC A;  2EVO A;  1M35 A;  1R58 A;  5CDL A;  3BIP A;  1R5G A;  4FLI A;  4U71 A;  3TAV A;  2EA2 A;  1KP0 A;  2GU7 A;  4S00 A;  3PKA A;  1WLR A;  1WN1 A;  4A6W A;  1YJ3 A;  1JAW A;  1N51 A;  3IG4 A;  3L24 A;  4S01 A;  1WKM A;  3FMR A;  2OAZ A;  1A16 A;  1BN5 A;  5CE6 A;  1XGO A;  3S6B A;  2GTX A;  5JI6 A;  3MR1 A;  1WY2 A;  2B3H A;  3MX6 A;  1YW8 A;  2GU6 A;  3CTZ A;  4FKC A;  1YVM A;  4EGE A;  2GG7 A;  4FUK A;  2BWY A;  4FLK A;  3BIQ A;  4RZZ A;  1KQ0 A;  4U6Z A;  5CIK A;  5CNX A;  1WL9 A;  1C24 A;  2BWV A;  3OVK A;  1XGS A;  2EA4 A;  2MAT A;  1B59 A;  3TB5 A;  3PKE A;  4U6E A;  2BWU A;  3RVA A;  1QZY A;  2GZ5 A;  4R60 A;  5E5B A;  4U69 A;  1PV9 A;  4U76 A;  4U6W A;  4QR8 A;  2GU5 A;  4ZWO A;  1C22 A;  2Q93 A;  4FLJ A;  2NQ7 A;  2BHC A;  2Q96 A;  5CDV A;  2IW2 A;  1MAT A;  1XGM A;  2Q8K A;  3PKC A;  4IKT A;  2ZSG A;  3IU7 A;  1CHM A;  3OOO A;  1KQ9 A;  1YW9 A;  4IKR A;  2ADU A;  2BHD A;  2HOW A;  2BN7 A;  4U1B A;  2BHA A;  4ZNG A;  4S2T P;  2GG3 A;  4MAT A;  4HXX A;  2V3Z A;  3I7M A;  3PEB A;  3D27 A;  2V3Y A;  2DFI A;  2NQ6 A;  2Q95 A;  4ZWU A;  4U70 A;  1W2M A;  2B3K A;  1QXW A;  2GGB A;  2BWT A;  4U73 A;  4FO8 A;  5FCH A;  2GA2 A;  2GGC A;  2OKN A;  5D6F A;  4RGZ 1;  1QXY A;  3ROR A;  2Q94 A;  3Q6D A;  4IF7 A;  4IDY A;  4IKS A;  1C27 A;  2GG0 A;  4FLL A;  4PNC A;  1C23 A;  2BWW A;  3BIT A;  5FCF A;  2BHB A;  1C21 A; 
#chains in the Genus database with same CATH homology
 2GG9 A;  4S2R P;  2V3X A;  2EVM A;  4OOK A;  2GG5 A;  4RZY A;  3CB5 A;  3IL0 A;  2G6P A;  4IU6 A;  2P9A A;  1O0X A;  3MAT A;  4FO7 A;  1B6A A;  1WBQ A;  3O5V A;  2GG2 A;  3PN9 A;  3PKD A;  4U6C A;  1W7V A;  1BOA A;  5CLS A;  5CDE A;  5D6E A;  3L7G A;  1XNZ A;  5E2C A;  3IU8 A;  3PKB A;  4IPA A;  4U75 A;  3FM3 A;  2BH3 A;  2BWX A;  1XGN A;  4PV4 A;  4IKU A;  5JHU A;  5JFR A;  3CB6 A;  4B28 A;  3IU9 A;  2BB7 A;  4U6J A;  2GU4 A;  4Z7M A;  1QXZ A;  1YW7 A;  1Y1N A;  1R5H A;  2Q92 A;  4IEC A;  3FMQ A;  4A6V A;  2P98 A;  2P99 A;  1WL6 A;  4ZWP A;  2GG8 A;  2B3L A;  2BWS A;  3QOC A;  4KM3 A;  4JUQ A;  2V6C A;  2EVC A;  2EVO A;  1M35 A;  1R58 A;  5CDL A;  3BIP A;  1R5G A;  4FLI A;  4U71 A;  3TAV A;  2EA2 A;  1KP0 A;  2GU7 A;  4S00 A;  3PKA A;  1WLR A;  1WN1 A;  4A6W A;  1YJ3 A;  1JAW A;  1N51 A;  3IG4 A;  3L24 A;  4S01 A;  1WKM A;  3FMR A;  2OAZ A;  1A16 A;  1BN5 A;  5CE6 A;  1XGO A;  3S6B A;  2GTX A;  5JI6 A;  3MR1 A;  1WY2 A;  2B3H A;  3MX6 A;  1YW8 A;  2GU6 A;  3CTZ A;  4FKC A;  1YVM A;  4EGE A;  2GG7 A;  4FUK A;  2BWY A;  4FLK A;  3BIQ A;  4RZZ A;  1KQ0 A;  4U6Z A;  5CIK A;  5CNX A;  1WL9 A;  1C24 A;  2BWV A;  3OVK A;  1XGS A;  2EA4 A;  2MAT A;  1B59 A;  3TB5 A;  3PKE A;  4U6E A;  2BWU A;  3RVA A;  1QZY A;  2GZ5 A;  4R60 A;  5E5B A;  4U69 A;  1PV9 A;  4U76 A;  4U6W A;  4QR8 A;  2GU5 A;  4ZWO A;  1C22 A;  2Q93 A;  4FLJ A;  2NQ7 A;  2BHC A;  2Q96 A;  5CDV A;  2IW2 A;  1MAT A;  1XGM A;  2Q8K A;  3PKC A;  4IKT A;  2ZSG A;  3IU7 A;  1CHM A;  3OOO A;  1KQ9 A;  1YW9 A;  4IKR A;  2ADU A;  2BHD A;  2HOW A;  2BN7 A;  4U1B A;  2BHA A;  4ZNG A;  4S2T P;  2GG3 A;  4MAT A;  4HXX A;  2V3Z A;  3I7M A;  3PEB A;  3D27 A;  2V3Y A;  2DFI A;  2NQ6 A;  2Q95 A;  4ZWU A;  4U70 A;  1W2M A;  2B3K A;  1QXW A;  2GGB A;  2BWT A;  4U73 A;  4FO8 A;  5FCH A;  2GA2 A;  2GGC A;  2OKN A;  5D6F A;  4RGZ 1;  1QXY A;  3ROR A;  2Q94 A;  3Q6D A;  4IF7 A;  4IDY A;  4IKS A;  1C27 A;  2GG0 A;  4FLL A;  4PNC A;  1C23 A;  2BWW A;  3BIT A;  5FCF A;  2BHB A;  1C21 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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