4EGEA

Crystal structure of dipeptidase pepe from mycobacterium ulcerans
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
371
structure length
371
Chain Sequence
GRFDTAVYARRLAAAAAATEQAGLAGLVITPGYDLRYLIGSRADTFERLTALVLPASGVPTIVLPRLELASLKESAASDLGVCVRDWVDGDDPYQLVAVALGGAPAATAVTDSMPALHLLPLADALGVLPVLATDVLRQLRMVKEAAEVDALAKAGAAIDRVHARVPAFLVPGRTEAQVAADIAEAIVAEGHSAVAFVIVGSGPHGADPHHGYSDRKLQVGDIVVVDIGGTYEPGYYSDSTRTYSIGDPSPDVAQQYSALQRAQRAAVDAVRPGVTAAQVDAAARDVLADAGLAEYFVHRTGHGIGLCVHEEPYIVAGNELPLVAGMAFSIEPGIYFPGRWGARIEDIVVVTENGALSVNNRPHELMVVPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium ulcerans
molecule tags Hydrolase
molecule keywords Dipeptidase PepE
total genus 124
structure length 371
sequence length 371
ec nomenclature
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF01321 Creatinase_N Creatinase/Prolidase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4egeA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4egeA02
2BWUA 4RZZA 2BWYA 2BHDA 2MATA 5JHUA 5D6FA 3OOOA 3PKDA 3MR1A 1O0XA 2GG0A 2GU4A 3IU8A 4OOKA 2EVCA 2HOWA 4FO7A 2V6CA 1WN1A 4IPAA 4Z7MA 3PKEA 3Q6DA 2Q93A 2IW2A 4U1BA 2Q96A 3PKAA 4S00A 1W2MA 2GG9A 2BHAA 1QXYA 3O5VA 3BIQA 2EA2A 4U6WA 4S2TP 4ZWOA 1N51A 1R58A 4U69A 3D27A 5CLSA 3CTZA 1KQ9A 4ZNGA 5CIKA 2P98A 4A6WA 5JFRA 1XGNA 3QOCA 1KQ0A 2GZ5A 1WLRA 4B28A 3L7GA 4IU6A 3TAVA 3PN9A 5E5BA 2GA2A 2Q94A 3IG4A 5CDLA 3PKCA 5CNXA 3IU9A 4JUQA 2GU7A 4PV4A 3RVAA 5CE6A 4U76A 4S2RP 4HXXA 2GG5A 5CDEA 1Y1NA 1R5HA 4FLKA 5D6EA 1XGMA 4U75A 2BWVA 1BOAA 1C27A 2DFIA 2GTXA 4FLJA 4MATA 4FO8A 2BWWA 1BN5A 1YW9A 3I7MA 4U6CA 2Q8KA 3OVKA 1W7VA 5JI6A 1B59A 4IDYA 4IKUA 4A6VA 3L24A 2B3LA 2P9AA 4FLIA 1XGSA 2GU5A 1JAWA 4IKTA 1WY2A 1WBQA 4U6ZA 4RZYA 3FMQA 4PNCA 4ZWPA 4FUKA 3BITA 3TB5A 3IU7A 4IKSA 2BWXA 2ZSGA 2B3KA 2V3ZA 4IKRA 1WKMA 1XGOA 3S6BA 4QR8A 1YVMA 3CB5A 1YJ3A 2GGBA 1WL6A 2EA4A 2GG7A 3PEBA 1WL9A 1B6AA 2GG3A 4IECA 2GU6A 3FMRA 2GGCA 2NQ7A 3CB6A 2BH3A 1A16A 4FKCA 4R60A 1C24A 2Q95A 4KM3A 4U6JA 2ADUA 1C23A 4RGZ1 2BHCA 4U6EA 1QXWA 1QZYA 2BHBA 3FM3A 3MATA 1PV9A 1C22A 2OKNA 3RORA 2GG8A 2P99A 2OAZA 1YW8A 4U70A 1R5GA 4S01A 4EGEA 2EVMA 5FCHA 4U71A 1MATA 1KP0A 3PKBA 3IL0A 2V3XA 2B3HA 3MX6A 2BWSA 3BIPA 5E2CA 1C21A 2NQ6A 4IF7A 4U73A 1CHMA 1XNZA 2BN7A 2V3YA 2EVOA 1M35A 2GG2A 2BWTA 1QXZA 4ZWUA 2G6PA 2Q92A 5CDVA 5FCFA 4FLLA 2BB7A 1YW7A
chains in the Genus database with same CATH superfamily
2BWUA 4RZZA 2BWYA 2BHDA 2MATA 5JHUA 5D6FA 3OOOA 3PKDA 3MR1A 1O0XA 2GG0A 2GU4A 3IU8A 4OOKA 2EVCA 2HOWA 4FO7A 2V6CA 1WN1A 4IPAA 4Z7MA 3PKEA 3Q6DA 2Q93A 2IW2A 4U1BA 2Q96A 3PKAA 4S00A 1W2MA 2GG9A 2BHAA 1QXYA 3O5VA 3BIQA 2EA2A 4U6WA 4S2TP 4ZWOA 1N51A 1R58A 4U69A 3D27A 5CLSA 3CTZA 1KQ9A 4ZNGA 5CIKA 2P98A 4A6WA 5JFRA 1XGNA 3QOCA 1KQ0A 2GZ5A 1WLRA 4B28A 3L7GA 4IU6A 3TAVA 3PN9A 5E5BA 2GA2A 2Q94A 3IG4A 5CDLA 3PKCA 5CNXA 3IU9A 4JUQA 2GU7A 4PV4A 3RVAA 5CE6A 4U76A 4S2RP 4HXXA 2GG5A 5CDEA 1Y1NA 1R5HA 4FLKA 5D6EA 1XGMA 4U75A 2BWVA 1BOAA 1C27A 2DFIA 2GTXA 4FLJA 4MATA 4FO8A 2BWWA 1BN5A 1YW9A 3I7MA 4U6CA 2Q8KA 3OVKA 1W7VA 5JI6A 1B59A 4IDYA 4IKUA 4A6VA 3L24A 2B3LA 2P9AA 4FLIA 1XGSA 2GU5A 1JAWA 4IKTA 1WY2A 1WBQA 4U6ZA 4RZYA 3FMQA 4PNCA 4ZWPA 4FUKA 3BITA 3TB5A 3IU7A 4IKSA 2BWXA 2ZSGA 2B3KA 2V3ZA 4IKRA 1WKMA 1XGOA 3S6BA 4QR8A 1YVMA 3CB5A 1YJ3A 2GGBA 1WL6A 2EA4A 2GG7A 3PEBA 1WL9A 1B6AA 2GG3A 4IECA 2GU6A 3FMRA 2GGCA 2NQ7A 3CB6A 2BH3A 1A16A 4FKCA 4R60A 1C24A 2Q95A 4KM3A 4U6JA 2ADUA 1C23A 4RGZ1 2BHCA 4U6EA 1QXWA 1QZYA 2BHBA 3FM3A 3MATA 1PV9A 1C22A 2OKNA 3RORA 2GG8A 2P99A 2OAZA 1YW8A 4U70A 1R5GA 4S01A 4EGEA 2EVMA 5FCHA 4U71A 1MATA 1KP0A 3PKBA 3IL0A 2V3XA 2B3HA 3MX6A 2BWSA 3BIPA 5E2CA 1C21A 2NQ6A 4IF7A 4U73A 1CHMA 1XNZA 2BN7A 2V3YA 2EVOA 1M35A 2GG2A 2BWTA 1QXZA 4ZWUA 2G6PA 2Q92A 5CDVA 5FCFA 4FLLA 2BB7A 1YW7A
chains in the Genus database with same CATH topology
2BWUA 4RZZA 2BWYA 2BHDA 2MATA 5JHUA 5D6FA 3OOOA 3PKDA 3MR1A 1O0XA 2GG0A 2GU4A 3IU8A 4OOKA 2EVCA 2HOWA 4FO7A 2V6CA 1WN1A 4IPAA 4Z7MA 3PKEA 3Q6DA 2Q93A 2IW2A 4U1BA 2Q96A 3PKAA 4S00A 1W2MA 2GG9A 2BHAA 1QXYA 3O5VA 3BIQA 2EA2A 4U6WA 4S2TP 4ZWOA 1N51A 1R58A 4U69A 3D27A 5CLSA 3CTZA 1KQ9A 4ZNGA 5CIKA 2P98A 4A6WA 5JFRA 1XGNA 3QOCA 1KQ0A 2GZ5A 1WLRA 4B28A 3L7GA 4IU6A 3TAVA 3PN9A 5E5BA 2GA2A 2Q94A 3IG4A 5CDLA 3PKCA 5CNXA 3IU9A 4JUQA 2GU7A 4PV4A 3RVAA 5CE6A 4U76A 4S2RP 4HXXA 2GG5A 5CDEA 1Y1NA 1R5HA 4FLKA 5D6EA 1XGMA 4U75A 2BWVA 1BOAA 1C27A 2DFIA 2GTXA 4FLJA 4MATA 4FO8A 2BWWA 1BN5A 1YW9A 3I7MA 4U6CA 2Q8KA 3OVKA 1W7VA 5JI6A 1B59A 4IDYA 4IKUA 4A6VA 3L24A 2B3LA 2P9AA 4FLIA 1XGSA 2GU5A 1JAWA 4IKTA 1WY2A 1WBQA 4U6ZA 4RZYA 3FMQA 4PNCA 4ZWPA 4FUKA 3BITA 3TB5A 3IU7A 4IKSA 2BWXA 2ZSGA 2B3KA 2V3ZA 4IKRA 1WKMA 1XGOA 3S6BA 4QR8A 1YVMA 3CB5A 1YJ3A 2GGBA 1WL6A 2EA4A 2GG7A 3PEBA 1WL9A 1B6AA 2GG3A 4IECA 2GU6A 3FMRA 2GGCA 2NQ7A 3CB6A 2BH3A 1A16A 4FKCA 4R60A 1C24A 2Q95A 4KM3A 4U6JA 2ADUA 1C23A 4RGZ1 2BHCA 4U6EA 1QXWA 1QZYA 2BHBA 3FM3A 3MATA 1PV9A 1C22A 2OKNA 3RORA 2GG8A 2P99A 2OAZA 1YW8A 4U70A 1R5GA 4S01A 4EGEA 2EVMA 5FCHA 4U71A 1MATA 1KP0A 3PKBA 3IL0A 2V3XA 2B3HA 3MX6A 2BWSA 3BIPA 5E2CA 1C21A 2NQ6A 4IF7A 4U73A 1CHMA 1XNZA 2BN7A 2V3YA 2EVOA 1M35A 2GG2A 2BWTA 1QXZA 4ZWUA 2G6PA 2Q92A 5CDVA 5FCFA 4FLLA 2BB7A 1YW7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BWU A;  4RZZ A;  2BWY A;  2BHD A;  2MAT A;  5JHU A;  5D6F A;  3OOO A;  3PKD A;  3MR1 A;  1O0X A;  2GG0 A;  2GU4 A;  3IU8 A;  4OOK A;  2EVC A;  2HOW A;  4FO7 A;  2V6C A;  1WN1 A;  4IPA A;  4Z7M A;  3PKE A;  3Q6D A;  2Q93 A;  2IW2 A;  4U1B A;  2Q96 A;  3PKA A;  4S00 A;  1W2M A;  2GG9 A;  2BHA A;  1QXY A;  3O5V A;  3BIQ A;  2EA2 A;  4U6W A;  4S2T P;  4ZWO A;  1N51 A;  1R58 A;  4U69 A;  3D27 A;  5CLS A;  3CTZ A;  1KQ9 A;  4ZNG A;  5CIK A;  2P98 A;  4A6W A;  5JFR A;  1XGN A;  3QOC A;  1KQ0 A;  2GZ5 A;  1WLR A;  4B28 A;  3L7G A;  4IU6 A;  3TAV A;  3PN9 A;  5E5B A;  2GA2 A;  2Q94 A;  3IG4 A;  5CDL A;  3PKC A;  5CNX A;  3IU9 A;  4JUQ A;  2GU7 A;  4PV4 A;  3RVA A;  5CE6 A;  4U76 A;  4S2R P;  4HXX A;  2GG5 A;  5CDE A;  1Y1N A;  1R5H A;  4FLK A;  5D6E A;  1XGM A;  4U75 A;  2BWV A;  1BOA A;  1C27 A;  2DFI A;  2GTX A;  4FLJ A;  4MAT A;  4FO8 A;  2BWW A;  1BN5 A;  1YW9 A;  3I7M A;  4U6C A;  2Q8K A;  3OVK A;  1W7V A;  5JI6 A;  1B59 A;  4IDY A;  4IKU A;  4A6V A;  3L24 A;  2B3L A;  2P9A A;  4FLI A;  1XGS A;  2GU5 A;  1JAW A;  4IKT A;  1WY2 A;  1WBQ A;  4U6Z A;  4RZY A;  3FMQ A;  4PNC A;  4ZWP A;  4FUK A;  3BIT A;  3TB5 A;  3IU7 A;  4IKS A;  2BWX A;  2ZSG A;  2B3K A;  2V3Z A;  4IKR A;  1WKM A;  1XGO A;  3S6B A;  4QR8 A;  1YVM A;  3CB5 A;  1YJ3 A;  2GGB A;  1WL6 A;  2EA4 A;  2GG7 A;  3PEB A;  1WL9 A;  1B6A A;  2GG3 A;  4IEC A;  2GU6 A;  3FMR A;  2GGC A;  2NQ7 A;  3CB6 A;  2BH3 A;  1A16 A;  4FKC A;  4R60 A;  1C24 A;  2Q95 A;  4KM3 A;  4U6J A;  2ADU A;  1C23 A;  4RGZ 1;  2BHC A;  4U6E A;  1QXW A;  1QZY A;  2BHB A;  3FM3 A;  3MAT A;  1PV9 A;  1C22 A;  2OKN A;  3ROR A;  2GG8 A;  2P99 A;  2OAZ A;  1YW8 A;  4U70 A;  1R5G A;  4S01 A;  4EGE A;  2EVM A;  5FCH A;  4U71 A;  1MAT A;  1KP0 A;  3PKB A;  3IL0 A;  2V3X A;  2B3H A;  3MX6 A;  2BWS A;  3BIP A;  5E2C A;  1C21 A;  2NQ6 A;  4IF7 A;  4U73 A;  1CHM A;  1XNZ A;  2BN7 A;  2V3Y A;  2EVO A;  1M35 A;  2GG2 A;  2BWT A;  1QXZ A;  4ZWU A;  2G6P A;  2Q92 A;  5CDV A;  5FCF A;  4FLL A;  2BB7 A;  1YW7 A; 
#chains in the Genus database with same CATH topology
 2BWU A;  4RZZ A;  2BWY A;  2BHD A;  2MAT A;  5JHU A;  5D6F A;  3OOO A;  3PKD A;  3MR1 A;  1O0X A;  2GG0 A;  2GU4 A;  3IU8 A;  4OOK A;  2EVC A;  2HOW A;  4FO7 A;  2V6C A;  1WN1 A;  4IPA A;  4Z7M A;  3PKE A;  3Q6D A;  2Q93 A;  2IW2 A;  4U1B A;  2Q96 A;  3PKA A;  4S00 A;  1W2M A;  2GG9 A;  2BHA A;  1QXY A;  3O5V A;  3BIQ A;  2EA2 A;  4U6W A;  4S2T P;  4ZWO A;  1N51 A;  1R58 A;  4U69 A;  3D27 A;  5CLS A;  3CTZ A;  1KQ9 A;  4ZNG A;  5CIK A;  2P98 A;  4A6W A;  5JFR A;  1XGN A;  3QOC A;  1KQ0 A;  2GZ5 A;  1WLR A;  4B28 A;  3L7G A;  4IU6 A;  3TAV A;  3PN9 A;  5E5B A;  2GA2 A;  2Q94 A;  3IG4 A;  5CDL A;  3PKC A;  5CNX A;  3IU9 A;  4JUQ A;  2GU7 A;  4PV4 A;  3RVA A;  5CE6 A;  4U76 A;  4S2R P;  4HXX A;  2GG5 A;  5CDE A;  1Y1N A;  1R5H A;  4FLK A;  5D6E A;  1XGM A;  4U75 A;  2BWV A;  1BOA A;  1C27 A;  2DFI A;  2GTX A;  4FLJ A;  4MAT A;  4FO8 A;  2BWW A;  1BN5 A;  1YW9 A;  3I7M A;  4U6C A;  2Q8K A;  3OVK A;  1W7V A;  5JI6 A;  1B59 A;  4IDY A;  4IKU A;  4A6V A;  3L24 A;  2B3L A;  2P9A A;  4FLI A;  1XGS A;  2GU5 A;  1JAW A;  4IKT A;  1WY2 A;  1WBQ A;  4U6Z A;  4RZY A;  3FMQ A;  4PNC A;  4ZWP A;  4FUK A;  3BIT A;  3TB5 A;  3IU7 A;  4IKS A;  2BWX A;  2ZSG A;  2B3K A;  2V3Z A;  4IKR A;  1WKM A;  1XGO A;  3S6B A;  4QR8 A;  1YVM A;  3CB5 A;  1YJ3 A;  2GGB A;  1WL6 A;  2EA4 A;  2GG7 A;  3PEB A;  1WL9 A;  1B6A A;  2GG3 A;  4IEC A;  2GU6 A;  3FMR A;  2GGC A;  2NQ7 A;  3CB6 A;  2BH3 A;  1A16 A;  4FKC A;  4R60 A;  1C24 A;  2Q95 A;  4KM3 A;  4U6J A;  2ADU A;  1C23 A;  4RGZ 1;  2BHC A;  4U6E A;  1QXW A;  1QZY A;  2BHB A;  3FM3 A;  3MAT A;  1PV9 A;  1C22 A;  2OKN A;  3ROR A;  2GG8 A;  2P99 A;  2OAZ A;  1YW8 A;  4U70 A;  1R5G A;  4S01 A;  4EGE A;  2EVM A;  5FCH A;  4U71 A;  1MAT A;  1KP0 A;  3PKB A;  3IL0 A;  2V3X A;  2B3H A;  3MX6 A;  2BWS A;  3BIP A;  5E2C A;  1C21 A;  2NQ6 A;  4IF7 A;  4U73 A;  1CHM A;  1XNZ A;  2BN7 A;  2V3Y A;  2EVO A;  1M35 A;  2GG2 A;  2BWT A;  1QXZ A;  4ZWU A;  2G6P A;  2Q92 A;  5CDV A;  5FCF A;  4FLL A;  2BB7 A;  1YW7 A; 
#chains in the Genus database with same CATH homology
 2BWU A;  4RZZ A;  2BWY A;  2BHD A;  2MAT A;  5JHU A;  5D6F A;  3OOO A;  3PKD A;  3MR1 A;  1O0X A;  2GG0 A;  2GU4 A;  3IU8 A;  4OOK A;  2EVC A;  2HOW A;  4FO7 A;  2V6C A;  1WN1 A;  4IPA A;  4Z7M A;  3PKE A;  3Q6D A;  2Q93 A;  2IW2 A;  4U1B A;  2Q96 A;  3PKA A;  4S00 A;  1W2M A;  2GG9 A;  2BHA A;  1QXY A;  3O5V A;  3BIQ A;  2EA2 A;  4U6W A;  4S2T P;  4ZWO A;  1N51 A;  1R58 A;  4U69 A;  3D27 A;  5CLS A;  3CTZ A;  1KQ9 A;  4ZNG A;  5CIK A;  2P98 A;  4A6W A;  5JFR A;  1XGN A;  3QOC A;  1KQ0 A;  2GZ5 A;  1WLR A;  4B28 A;  3L7G A;  4IU6 A;  3TAV A;  3PN9 A;  5E5B A;  2GA2 A;  2Q94 A;  3IG4 A;  5CDL A;  3PKC A;  5CNX A;  3IU9 A;  4JUQ A;  2GU7 A;  4PV4 A;  3RVA A;  5CE6 A;  4U76 A;  4S2R P;  4HXX A;  2GG5 A;  5CDE A;  1Y1N A;  1R5H A;  4FLK A;  5D6E A;  1XGM A;  4U75 A;  2BWV A;  1BOA A;  1C27 A;  2DFI A;  2GTX A;  4FLJ A;  4MAT A;  4FO8 A;  2BWW A;  1BN5 A;  1YW9 A;  3I7M A;  4U6C A;  2Q8K A;  3OVK A;  1W7V A;  5JI6 A;  1B59 A;  4IDY A;  4IKU A;  4A6V A;  3L24 A;  2B3L A;  2P9A A;  4FLI A;  1XGS A;  2GU5 A;  1JAW A;  4IKT A;  1WY2 A;  1WBQ A;  4U6Z A;  4RZY A;  3FMQ A;  4PNC A;  4ZWP A;  4FUK A;  3BIT A;  3TB5 A;  3IU7 A;  4IKS A;  2BWX A;  2ZSG A;  2B3K A;  2V3Z A;  4IKR A;  1WKM A;  1XGO A;  3S6B A;  4QR8 A;  1YVM A;  3CB5 A;  1YJ3 A;  2GGB A;  1WL6 A;  2EA4 A;  2GG7 A;  3PEB A;  1WL9 A;  1B6A A;  2GG3 A;  4IEC A;  2GU6 A;  3FMR A;  2GGC A;  2NQ7 A;  3CB6 A;  2BH3 A;  1A16 A;  4FKC A;  4R60 A;  1C24 A;  2Q95 A;  4KM3 A;  4U6J A;  2ADU A;  1C23 A;  4RGZ 1;  2BHC A;  4U6E A;  1QXW A;  1QZY A;  2BHB A;  3FM3 A;  3MAT A;  1PV9 A;  1C22 A;  2OKN A;  3ROR A;  2GG8 A;  2P99 A;  2OAZ A;  1YW8 A;  4U70 A;  1R5G A;  4S01 A;  4EGE A;  2EVM A;  5FCH A;  4U71 A;  1MAT A;  1KP0 A;  3PKB A;  3IL0 A;  2V3X A;  2B3H A;  3MX6 A;  2BWS A;  3BIP A;  5E2C A;  1C21 A;  2NQ6 A;  4IF7 A;  4U73 A;  1CHM A;  1XNZ A;  2BN7 A;  2V3Y A;  2EVO A;  1M35 A;  2GG2 A;  2BWT A;  1QXZ A;  4ZWU A;  2G6P A;  2Q92 A;  5CDV A;  5FCF A;  4FLL A;  2BB7 A;  1YW7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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