4EGEA

Crystal structure of dipeptidase pepe from mycobacterium ulcerans
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
371
structure length
371
Chain Sequence
GRFDTAVYARRLAAAAAATEQAGLAGLVITPGYDLRYLIGSRADTFERLTALVLPASGVPTIVLPRLELASLKESAASDLGVCVRDWVDGDDPYQLVAVALGGAPAATAVTDSMPALHLLPLADALGVLPVLATDVLRQLRMVKEAAEVDALAKAGAAIDRVHARVPAFLVPGRTEAQVAADIAEAIVAEGHSAVAFVIVGSGPHGADPHHGYSDRKLQVGDIVVVDIGGTYEPGYYSDSTRTYSIGDPSPDVAQQYSALQRAQRAAVDAVRPGVTAAQVDAAARDVLADAGLAEYFVHRTGHGIGLCVHEEPYIVAGNELPLVAGMAFSIEPGIYFPGRWGARIEDIVVVTENGALSVNNRPHELMVVPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Dipeptidase PepE
publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium ulcerans
total genus 124
structure length 371
sequence length 371
ec nomenclature
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF01321 Creatinase_N Creatinase/Prolidase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4egeA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4egeA02
3D27A 4IU6A 4ZWUA 2V6CA 1W7VA 1XGMA 3RVAA 5CLSA 3BIPA 1BOAA 2GG8A 4RZYA 2GU7A 1WN1A 4S01A 3MR1A 1R58A 1XNZA 3QOCA 1C23A 4IKUA 4FO8A 3FMQA 1A16A 5JHUA 2B3LA 2BHCA 4S00A 5D6EA 1QZYA 2P9AA 3IU7A 4U69A 5CDEA 3Q6DA 1B59A 1WLRA 3CB6A 3RORA 4A6VA 4ZNGA 3MATA 3IU9A 4HXXA 2NQ6A 2BHBA 4FLKA 4U6WA 5CNXA 3OOOA 2G6PA 2EVCA 2GG9A 4IKRA 3TAVA 5CIKA 2ZSGA 4U6JA 4U73A 4B28A 5E5BA 1JAWA 1QXZA 4U71A 4FO7A 4U6EA 3PN9A 1W2MA 4QR8A 1YVMA 2Q94A 5D6FA 4Z7MA 4S2RP 2BN7A 3L7GA 3PKDA 4FKCA 3PKCA 2P99A 4U70A 3S6BA 4IDYA 4U6ZA 1YW7A 2V3ZA 2GG7A 5JI6A 1N51A 2OKNA 2BWYA 4FUKA 2GU4A 1XGNA 4ZWPA 2EVMA 2GU6A 2NQ7A 2Q92A 4IKSA 2GTXA 2EA4A 2GG2A 1WL9A 1R5HA 1Y1NA 3OVKA 2BWXA 1MATA 4IF7A 3O5VA 2EA2A 3IL0A 4ZWOA 1QXYA 2ADUA 2Q95A 5CDLA 3PKEA 2MATA 2BHDA 4IPAA 4JUQA 3MX6A 2V3YA 2GGCA 3TB5A 3I7MA 1QXWA 2BWVA 2BWSA 2V3XA 2GGBA 2BWWA 3BITA 1YJ3A 2B3HA 1KP0A 4FLJA 3FM3A 1B6AA 1YW9A 4U76A 1R5GA 5FCFA 1BN5A 2GZ5A 2OAZA 4FLIA 2HOWA 4RGZ1 2GG0A 4FLLA 4U75A 4S2TP 3IG4A 4U1BA 5CE6A 2BHAA 3PKAA 4RZZA 5CDVA 2GU5A 1CHMA 1XGOA 2DFIA 4EGEA 1WBQA 4IKTA 2Q96A 2GG5A 1WL6A 4PNCA 1C27A 4PV4A 3PKBA 4A6WA 1C21A 2IW2A 2B3KA 3FMRA 4MATA 1C24A 5FCHA 2GG3A 2P98A 3L24A 1C22A 2BH3A 4R60A 4OOKA 4IECA 1YW8A 2EVOA 1M35A 1KQ0A 4U6CA 2GA2A 1WY2A 3CB5A 3BIQA 1KQ9A 4KM3A 1XGSA 2BWUA 2Q93A 1PV9A 2BWTA 3PEBA 3CTZA 1WKMA 3IU8A 2Q8KA 5JFRA 1O0XA 2BB7A 5E2CA
chains in the Genus database with same CATH superfamily
3D27A 4IU6A 4ZWUA 2V6CA 1W7VA 1XGMA 3RVAA 5CLSA 3BIPA 1BOAA 2GG8A 4RZYA 2GU7A 1WN1A 4S01A 3MR1A 1R58A 1XNZA 3QOCA 1C23A 4IKUA 4FO8A 3FMQA 1A16A 5JHUA 2B3LA 2BHCA 4S00A 5D6EA 1QZYA 2P9AA 3IU7A 4U69A 5CDEA 3Q6DA 1B59A 1WLRA 3CB6A 3RORA 4A6VA 4ZNGA 3MATA 3IU9A 4HXXA 2NQ6A 2BHBA 4FLKA 4U6WA 5CNXA 3OOOA 2G6PA 2EVCA 2GG9A 4IKRA 3TAVA 5CIKA 2ZSGA 4U6JA 4U73A 4B28A 5E5BA 1JAWA 1QXZA 4U71A 4FO7A 4U6EA 3PN9A 1W2MA 4QR8A 1YVMA 2Q94A 5D6FA 4Z7MA 4S2RP 2BN7A 3L7GA 3PKDA 4FKCA 3PKCA 2P99A 4U70A 3S6BA 4IDYA 4U6ZA 1YW7A 2V3ZA 2GG7A 5JI6A 1N51A 2OKNA 2BWYA 4FUKA 2GU4A 1XGNA 4ZWPA 2EVMA 2GU6A 2NQ7A 2Q92A 4IKSA 2GTXA 2EA4A 2GG2A 1WL9A 1R5HA 1Y1NA 3OVKA 2BWXA 1MATA 4IF7A 3O5VA 2EA2A 3IL0A 4ZWOA 1QXYA 2ADUA 2Q95A 5CDLA 3PKEA 2MATA 2BHDA 4IPAA 4JUQA 3MX6A 2V3YA 2GGCA 3TB5A 3I7MA 1QXWA 2BWVA 2BWSA 2V3XA 2GGBA 2BWWA 3BITA 1YJ3A 2B3HA 1KP0A 4FLJA 3FM3A 1B6AA 1YW9A 4U76A 1R5GA 5FCFA 1BN5A 2GZ5A 2OAZA 4FLIA 2HOWA 4RGZ1 2GG0A 4FLLA 4U75A 4S2TP 3IG4A 4U1BA 5CE6A 2BHAA 3PKAA 4RZZA 5CDVA 2GU5A 1CHMA 1XGOA 2DFIA 4EGEA 1WBQA 4IKTA 2Q96A 2GG5A 1WL6A 4PNCA 1C27A 4PV4A 3PKBA 4A6WA 1C21A 2IW2A 2B3KA 3FMRA 4MATA 1C24A 5FCHA 2GG3A 2P98A 3L24A 1C22A 2BH3A 4R60A 4OOKA 4IECA 1YW8A 2EVOA 1M35A 1KQ0A 4U6CA 2GA2A 1WY2A 3CB5A 3BIQA 1KQ9A 4KM3A 1XGSA 2BWUA 2Q93A 1PV9A 2BWTA 3PEBA 3CTZA 1WKMA 3IU8A 2Q8KA 5JFRA 1O0XA 2BB7A 5E2CA
chains in the Genus database with same CATH topology
3D27A 4IU6A 4ZWUA 2V6CA 1W7VA 1XGMA 3RVAA 5CLSA 3BIPA 1BOAA 2GG8A 4RZYA 2GU7A 1WN1A 4S01A 3MR1A 1R58A 1XNZA 3QOCA 1C23A 4IKUA 4FO8A 3FMQA 1A16A 5JHUA 2B3LA 2BHCA 4S00A 5D6EA 1QZYA 2P9AA 3IU7A 4U69A 5CDEA 3Q6DA 1B59A 1WLRA 3CB6A 3RORA 4A6VA 4ZNGA 3MATA 3IU9A 4HXXA 2NQ6A 2BHBA 4FLKA 4U6WA 5CNXA 3OOOA 2G6PA 2EVCA 2GG9A 4IKRA 3TAVA 5CIKA 2ZSGA 4U6JA 4U73A 4B28A 5E5BA 1JAWA 1QXZA 4U71A 4FO7A 4U6EA 3PN9A 1W2MA 4QR8A 1YVMA 2Q94A 5D6FA 4Z7MA 4S2RP 2BN7A 3L7GA 3PKDA 4FKCA 3PKCA 2P99A 4U70A 3S6BA 4IDYA 4U6ZA 1YW7A 2V3ZA 2GG7A 5JI6A 1N51A 2OKNA 2BWYA 4FUKA 2GU4A 1XGNA 4ZWPA 2EVMA 2GU6A 2NQ7A 2Q92A 4IKSA 2GTXA 2EA4A 2GG2A 1WL9A 1R5HA 1Y1NA 3OVKA 2BWXA 1MATA 4IF7A 3O5VA 2EA2A 3IL0A 4ZWOA 1QXYA 2ADUA 2Q95A 5CDLA 3PKEA 2MATA 2BHDA 4IPAA 4JUQA 3MX6A 2V3YA 2GGCA 3TB5A 3I7MA 1QXWA 2BWVA 2BWSA 2V3XA 2GGBA 2BWWA 3BITA 1YJ3A 2B3HA 1KP0A 4FLJA 3FM3A 1B6AA 1YW9A 4U76A 1R5GA 5FCFA 1BN5A 2GZ5A 2OAZA 4FLIA 2HOWA 4RGZ1 2GG0A 4FLLA 4U75A 4S2TP 3IG4A 4U1BA 5CE6A 2BHAA 3PKAA 4RZZA 5CDVA 2GU5A 1CHMA 1XGOA 2DFIA 4EGEA 1WBQA 4IKTA 2Q96A 2GG5A 1WL6A 4PNCA 1C27A 4PV4A 3PKBA 4A6WA 1C21A 2IW2A 2B3KA 3FMRA 4MATA 1C24A 5FCHA 2GG3A 2P98A 3L24A 1C22A 2BH3A 4R60A 4OOKA 4IECA 1YW8A 2EVOA 1M35A 1KQ0A 4U6CA 2GA2A 1WY2A 3CB5A 3BIQA 1KQ9A 4KM3A 1XGSA 2BWUA 2Q93A 1PV9A 2BWTA 3PEBA 3CTZA 1WKMA 3IU8A 2Q8KA 5JFRA 1O0XA 2BB7A 5E2CA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3D27 A;  4IU6 A;  4ZWU A;  2V6C A;  1W7V A;  1XGM A;  3RVA A;  5CLS A;  3BIP A;  1BOA A;  2GG8 A;  4RZY A;  2GU7 A;  1WN1 A;  4S01 A;  3MR1 A;  1R58 A;  1XNZ A;  3QOC A;  1C23 A;  4IKU A;  4FO8 A;  3FMQ A;  1A16 A;  5JHU A;  2B3L A;  2BHC A;  4S00 A;  5D6E A;  1QZY A;  2P9A A;  3IU7 A;  4U69 A;  5CDE A;  3Q6D A;  1B59 A;  1WLR A;  3CB6 A;  3ROR A;  4A6V A;  4ZNG A;  3MAT A;  3IU9 A;  4HXX A;  2NQ6 A;  2BHB A;  4FLK A;  4U6W A;  5CNX A;  3OOO A;  2G6P A;  2EVC A;  2GG9 A;  4IKR A;  3TAV A;  5CIK A;  2ZSG A;  4U6J A;  4U73 A;  4B28 A;  5E5B A;  1JAW A;  1QXZ A;  4U71 A;  4FO7 A;  4U6E A;  3PN9 A;  1W2M A;  4QR8 A;  1YVM A;  2Q94 A;  5D6F A;  4Z7M A;  4S2R P;  2BN7 A;  3L7G A;  3PKD A;  4FKC A;  3PKC A;  2P99 A;  4U70 A;  3S6B A;  4IDY A;  4U6Z A;  1YW7 A;  2V3Z A;  2GG7 A;  5JI6 A;  1N51 A;  2OKN A;  2BWY A;  4FUK A;  2GU4 A;  1XGN A;  4ZWP A;  2EVM A;  2GU6 A;  2NQ7 A;  2Q92 A;  4IKS A;  2GTX A;  2EA4 A;  2GG2 A;  1WL9 A;  1R5H A;  1Y1N A;  3OVK A;  2BWX A;  1MAT A;  4IF7 A;  3O5V A;  2EA2 A;  3IL0 A;  4ZWO A;  1QXY A;  2ADU A;  2Q95 A;  5CDL A;  3PKE A;  2MAT A;  2BHD A;  4IPA A;  4JUQ A;  3MX6 A;  2V3Y A;  2GGC A;  3TB5 A;  3I7M A;  1QXW A;  2BWV A;  2BWS A;  2V3X A;  2GGB A;  2BWW A;  3BIT A;  1YJ3 A;  2B3H A;  1KP0 A;  4FLJ A;  3FM3 A;  1B6A A;  1YW9 A;  4U76 A;  1R5G A;  5FCF A;  1BN5 A;  2GZ5 A;  2OAZ A;  4FLI A;  2HOW A;  4RGZ 1;  2GG0 A;  4FLL A;  4U75 A;  4S2T P;  3IG4 A;  4U1B A;  5CE6 A;  2BHA A;  3PKA A;  4RZZ A;  5CDV A;  2GU5 A;  1CHM A;  1XGO A;  2DFI A;  4EGE A;  1WBQ A;  4IKT A;  2Q96 A;  2GG5 A;  1WL6 A;  4PNC A;  1C27 A;  4PV4 A;  3PKB A;  4A6W A;  1C21 A;  2IW2 A;  2B3K A;  3FMR A;  4MAT A;  1C24 A;  5FCH A;  2GG3 A;  2P98 A;  3L24 A;  1C22 A;  2BH3 A;  4R60 A;  4OOK A;  4IEC A;  1YW8 A;  2EVO A;  1M35 A;  1KQ0 A;  4U6C A;  2GA2 A;  1WY2 A;  3CB5 A;  3BIQ A;  1KQ9 A;  4KM3 A;  1XGS A;  2BWU A;  2Q93 A;  1PV9 A;  2BWT A;  3PEB A;  3CTZ A;  1WKM A;  3IU8 A;  2Q8K A;  5JFR A;  1O0X A;  2BB7 A;  5E2C A; 
#chains in the Genus database with same CATH topology
 3D27 A;  4IU6 A;  4ZWU A;  2V6C A;  1W7V A;  1XGM A;  3RVA A;  5CLS A;  3BIP A;  1BOA A;  2GG8 A;  4RZY A;  2GU7 A;  1WN1 A;  4S01 A;  3MR1 A;  1R58 A;  1XNZ A;  3QOC A;  1C23 A;  4IKU A;  4FO8 A;  3FMQ A;  1A16 A;  5JHU A;  2B3L A;  2BHC A;  4S00 A;  5D6E A;  1QZY A;  2P9A A;  3IU7 A;  4U69 A;  5CDE A;  3Q6D A;  1B59 A;  1WLR A;  3CB6 A;  3ROR A;  4A6V A;  4ZNG A;  3MAT A;  3IU9 A;  4HXX A;  2NQ6 A;  2BHB A;  4FLK A;  4U6W A;  5CNX A;  3OOO A;  2G6P A;  2EVC A;  2GG9 A;  4IKR A;  3TAV A;  5CIK A;  2ZSG A;  4U6J A;  4U73 A;  4B28 A;  5E5B A;  1JAW A;  1QXZ A;  4U71 A;  4FO7 A;  4U6E A;  3PN9 A;  1W2M A;  4QR8 A;  1YVM A;  2Q94 A;  5D6F A;  4Z7M A;  4S2R P;  2BN7 A;  3L7G A;  3PKD A;  4FKC A;  3PKC A;  2P99 A;  4U70 A;  3S6B A;  4IDY A;  4U6Z A;  1YW7 A;  2V3Z A;  2GG7 A;  5JI6 A;  1N51 A;  2OKN A;  2BWY A;  4FUK A;  2GU4 A;  1XGN A;  4ZWP A;  2EVM A;  2GU6 A;  2NQ7 A;  2Q92 A;  4IKS A;  2GTX A;  2EA4 A;  2GG2 A;  1WL9 A;  1R5H A;  1Y1N A;  3OVK A;  2BWX A;  1MAT A;  4IF7 A;  3O5V A;  2EA2 A;  3IL0 A;  4ZWO A;  1QXY A;  2ADU A;  2Q95 A;  5CDL A;  3PKE A;  2MAT A;  2BHD A;  4IPA A;  4JUQ A;  3MX6 A;  2V3Y A;  2GGC A;  3TB5 A;  3I7M A;  1QXW A;  2BWV A;  2BWS A;  2V3X A;  2GGB A;  2BWW A;  3BIT A;  1YJ3 A;  2B3H A;  1KP0 A;  4FLJ A;  3FM3 A;  1B6A A;  1YW9 A;  4U76 A;  1R5G A;  5FCF A;  1BN5 A;  2GZ5 A;  2OAZ A;  4FLI A;  2HOW A;  4RGZ 1;  2GG0 A;  4FLL A;  4U75 A;  4S2T P;  3IG4 A;  4U1B A;  5CE6 A;  2BHA A;  3PKA A;  4RZZ A;  5CDV A;  2GU5 A;  1CHM A;  1XGO A;  2DFI A;  4EGE A;  1WBQ A;  4IKT A;  2Q96 A;  2GG5 A;  1WL6 A;  4PNC A;  1C27 A;  4PV4 A;  3PKB A;  4A6W A;  1C21 A;  2IW2 A;  2B3K A;  3FMR A;  4MAT A;  1C24 A;  5FCH A;  2GG3 A;  2P98 A;  3L24 A;  1C22 A;  2BH3 A;  4R60 A;  4OOK A;  4IEC A;  1YW8 A;  2EVO A;  1M35 A;  1KQ0 A;  4U6C A;  2GA2 A;  1WY2 A;  3CB5 A;  3BIQ A;  1KQ9 A;  4KM3 A;  1XGS A;  2BWU A;  2Q93 A;  1PV9 A;  2BWT A;  3PEB A;  3CTZ A;  1WKM A;  3IU8 A;  2Q8K A;  5JFR A;  1O0X A;  2BB7 A;  5E2C A; 
#chains in the Genus database with same CATH homology
 3D27 A;  4IU6 A;  4ZWU A;  2V6C A;  1W7V A;  1XGM A;  3RVA A;  5CLS A;  3BIP A;  1BOA A;  2GG8 A;  4RZY A;  2GU7 A;  1WN1 A;  4S01 A;  3MR1 A;  1R58 A;  1XNZ A;  3QOC A;  1C23 A;  4IKU A;  4FO8 A;  3FMQ A;  1A16 A;  5JHU A;  2B3L A;  2BHC A;  4S00 A;  5D6E A;  1QZY A;  2P9A A;  3IU7 A;  4U69 A;  5CDE A;  3Q6D A;  1B59 A;  1WLR A;  3CB6 A;  3ROR A;  4A6V A;  4ZNG A;  3MAT A;  3IU9 A;  4HXX A;  2NQ6 A;  2BHB A;  4FLK A;  4U6W A;  5CNX A;  3OOO A;  2G6P A;  2EVC A;  2GG9 A;  4IKR A;  3TAV A;  5CIK A;  2ZSG A;  4U6J A;  4U73 A;  4B28 A;  5E5B A;  1JAW A;  1QXZ A;  4U71 A;  4FO7 A;  4U6E A;  3PN9 A;  1W2M A;  4QR8 A;  1YVM A;  2Q94 A;  5D6F A;  4Z7M A;  4S2R P;  2BN7 A;  3L7G A;  3PKD A;  4FKC A;  3PKC A;  2P99 A;  4U70 A;  3S6B A;  4IDY A;  4U6Z A;  1YW7 A;  2V3Z A;  2GG7 A;  5JI6 A;  1N51 A;  2OKN A;  2BWY A;  4FUK A;  2GU4 A;  1XGN A;  4ZWP A;  2EVM A;  2GU6 A;  2NQ7 A;  2Q92 A;  4IKS A;  2GTX A;  2EA4 A;  2GG2 A;  1WL9 A;  1R5H A;  1Y1N A;  3OVK A;  2BWX A;  1MAT A;  4IF7 A;  3O5V A;  2EA2 A;  3IL0 A;  4ZWO A;  1QXY A;  2ADU A;  2Q95 A;  5CDL A;  3PKE A;  2MAT A;  2BHD A;  4IPA A;  4JUQ A;  3MX6 A;  2V3Y A;  2GGC A;  3TB5 A;  3I7M A;  1QXW A;  2BWV A;  2BWS A;  2V3X A;  2GGB A;  2BWW A;  3BIT A;  1YJ3 A;  2B3H A;  1KP0 A;  4FLJ A;  3FM3 A;  1B6A A;  1YW9 A;  4U76 A;  1R5G A;  5FCF A;  1BN5 A;  2GZ5 A;  2OAZ A;  4FLI A;  2HOW A;  4RGZ 1;  2GG0 A;  4FLL A;  4U75 A;  4S2T P;  3IG4 A;  4U1B A;  5CE6 A;  2BHA A;  3PKA A;  4RZZ A;  5CDV A;  2GU5 A;  1CHM A;  1XGO A;  2DFI A;  4EGE A;  1WBQ A;  4IKT A;  2Q96 A;  2GG5 A;  1WL6 A;  4PNC A;  1C27 A;  4PV4 A;  3PKB A;  4A6W A;  1C21 A;  2IW2 A;  2B3K A;  3FMR A;  4MAT A;  1C24 A;  5FCH A;  2GG3 A;  2P98 A;  3L24 A;  1C22 A;  2BH3 A;  4R60 A;  4OOK A;  4IEC A;  1YW8 A;  2EVO A;  1M35 A;  1KQ0 A;  4U6C A;  2GA2 A;  1WY2 A;  3CB5 A;  3BIQ A;  1KQ9 A;  4KM3 A;  1XGS A;  2BWU A;  2Q93 A;  1PV9 A;  2BWT A;  3PEB A;  3CTZ A;  1WKM A;  3IU8 A;  2Q8K A;  5JFR A;  1O0X A;  2BB7 A;  5E2C A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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