4EGEA

Crystal structure of dipeptidase pepe from mycobacterium ulcerans
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
371
structure length
371
Chain Sequence
GRFDTAVYARRLAAAAAATEQAGLAGLVITPGYDLRYLIGSRADTFERLTALVLPASGVPTIVLPRLELASLKESAASDLGVCVRDWVDGDDPYQLVAVALGGAPAATAVTDSMPALHLLPLADALGVLPVLATDVLRQLRMVKEAAEVDALAKAGAAIDRVHARVPAFLVPGRTEAQVAADIAEAIVAEGHSAVAFVIVGSGPHGADPHHGYSDRKLQVGDIVVVDIGGTYEPGYYSDSTRTYSIGDPSPDVAQQYSALQRAQRAAVDAVRPGVTAAQVDAAARDVLADAGLAEYFVHRTGHGIGLCVHEEPYIVAGNELPLVAGMAFSIEPGIYFPGRWGARIEDIVVVTENGALSVNNRPHELMVVPV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Increasing the structural coverage of tuberculosis drug targets.
pubmed doi rcsb
source organism Mycobacterium ulcerans
molecule tags Hydrolase
molecule keywords Dipeptidase PepE
total genus 124
structure length 371
sequence length 371
ec nomenclature
pdb deposition date 2012-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF01321 Creatinase_N Creatinase/Prolidase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4egeA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4egeA02
4U73A 1BN5A 3BIQA 1MATA 5CIKA 1WL9A 3I7MA 3RVAA 3CB6A 4U70A 4RGZ1 4MATA 4JUQA 2BN7A 1B6AA 4FLIA 3L7GA 1XGSA 2BWYA 3TB5A 2BHAA 5CDLA 2V3XA 1YVMA 3PKDA 2NQ7A 3MR1A 2G6PA 2OKNA 2OAZA 1QXZA 2BWVA 2GG2A 2V3YA 2EA2A 3Q6DA 2GU5A 5CNXA 4S2RP 4S2TP 1C22A 2P9AA 4ZWPA 2BWXA 4IDYA 4U71A 1N51A 3PN9A 2EA4A 4U6JA 4U6ZA 5JI6A 4U1BA 4U6CA 4U76A 1WL6A 5FCHA 4S00A 1YW8A 1R5GA 4S01A 1YJ3A 1YW7A 5JFRA 1R58A 2GG9A 2MATA 1XGMA 3S6BA 2GG3A 2BHBA 5D6FA 4FO8A 4FUKA 2GU6A 3FMQA 3IG4A 1KQ9A 1QXYA 3IU9A 2NQ6A 5CE6A 1BOAA 1KQ0A 4FLKA 1WKMA 1W2MA 2Q8KA 1WBQA 2B3LA 2GG5A 2Q95A 3CB5A 3OOOA 4IF7A 4KM3A 2GU7A 1WLRA 4IU6A 4HXXA 4B28A 2BHCA 1PV9A 4U69A 2HOWA 4FKCA 2BWTA 2P99A 4U75A 4IKTA 4A6WA 3L24A 4IECA 1KP0A 2V6CA 2B3HA 2IW2A 3FM3A 5JHUA 2BWUA 1C21A 1O0XA 3RORA 1WY2A 2GG8A 4PNCA 5E5BA 3PKBA 3IU8A 1C27A 1XGNA 3OVKA 2EVCA 1YW9A 2BB7A 3PKCA 5D6EA 1C23A 2GTXA 2Q96A 4A6VA 5CDVA 2BWWA 3PKAA 4IKUA 3PKEA 1QZYA 2GG0A 3D27A 2Q92A 3FMRA 3IL0A 1XNZA 1XGOA 2Q93A 3CTZA 1QXWA 3PEBA 3BITA 5CDEA 2DFIA 3IU7A 2GU4A 3BIPA 1C24A 5E2CA 1JAWA 5FCFA 5CLSA 4U6EA 4U6WA 4ZNGA 2GGCA 4FLJA 2EVMA 4RZYA 4FLLA 2GZ5A 4Z7MA 2EVOA 3QOCA 4OOKA 1B59A 2ZSGA 1Y1NA 4ZWUA 2B3KA 4PV4A 4ZWOA 3MATA 4FO7A 1CHMA 1W7VA 1M35A 4IPAA 2ADUA 2Q94A 4IKSA 2P98A 2GGBA 4EGEA 1A16A 2GG7A 4QR8A 4IKRA 2GA2A 3TAVA 3O5VA 2BH3A 2BWSA 4R60A 2BHDA 3MX6A 2V3ZA 1WN1A 4RZZA 1R5HA
chains in the Genus database with same CATH superfamily
4U73A 1BN5A 3BIQA 1MATA 5CIKA 1WL9A 3I7MA 3RVAA 3CB6A 4U70A 4RGZ1 4MATA 4JUQA 2BN7A 1B6AA 4FLIA 3L7GA 1XGSA 2BWYA 3TB5A 2BHAA 5CDLA 2V3XA 1YVMA 3PKDA 2NQ7A 3MR1A 2G6PA 2OKNA 2OAZA 1QXZA 2BWVA 2GG2A 2V3YA 2EA2A 3Q6DA 2GU5A 5CNXA 4S2RP 4S2TP 1C22A 2P9AA 4ZWPA 2BWXA 4IDYA 4U71A 1N51A 3PN9A 2EA4A 4U6JA 4U6ZA 5JI6A 4U1BA 4U6CA 4U76A 1WL6A 5FCHA 4S00A 1YW8A 1R5GA 4S01A 1YJ3A 1YW7A 5JFRA 1R58A 2GG9A 2MATA 1XGMA 3S6BA 2GG3A 2BHBA 5D6FA 4FO8A 4FUKA 2GU6A 3FMQA 3IG4A 1KQ9A 1QXYA 3IU9A 2NQ6A 5CE6A 1BOAA 1KQ0A 4FLKA 1WKMA 1W2MA 2Q8KA 1WBQA 2B3LA 2GG5A 2Q95A 3CB5A 3OOOA 4IF7A 4KM3A 2GU7A 1WLRA 4IU6A 4HXXA 4B28A 2BHCA 1PV9A 4U69A 2HOWA 4FKCA 2BWTA 2P99A 4U75A 4IKTA 4A6WA 3L24A 4IECA 1KP0A 2V6CA 2B3HA 2IW2A 3FM3A 5JHUA 2BWUA 1C21A 1O0XA 3RORA 1WY2A 2GG8A 4PNCA 5E5BA 3PKBA 3IU8A 1C27A 1XGNA 3OVKA 2EVCA 1YW9A 2BB7A 3PKCA 5D6EA 1C23A 2GTXA 2Q96A 4A6VA 5CDVA 2BWWA 3PKAA 4IKUA 3PKEA 1QZYA 2GG0A 3D27A 2Q92A 3FMRA 3IL0A 1XNZA 1XGOA 2Q93A 3CTZA 1QXWA 3PEBA 3BITA 5CDEA 2DFIA 3IU7A 2GU4A 3BIPA 1C24A 5E2CA 1JAWA 5FCFA 5CLSA 4U6EA 4U6WA 4ZNGA 2GGCA 4FLJA 2EVMA 4RZYA 4FLLA 2GZ5A 4Z7MA 2EVOA 3QOCA 4OOKA 1B59A 2ZSGA 1Y1NA 4ZWUA 2B3KA 4PV4A 4ZWOA 3MATA 4FO7A 1CHMA 1W7VA 1M35A 4IPAA 2ADUA 2Q94A 4IKSA 2P98A 2GGBA 4EGEA 1A16A 2GG7A 4QR8A 4IKRA 2GA2A 3TAVA 3O5VA 2BH3A 2BWSA 4R60A 2BHDA 3MX6A 2V3ZA 1WN1A 4RZZA 1R5HA
chains in the Genus database with same CATH topology
4U73A 1BN5A 3BIQA 1MATA 5CIKA 1WL9A 3I7MA 3RVAA 3CB6A 4U70A 4RGZ1 4MATA 4JUQA 2BN7A 1B6AA 4FLIA 3L7GA 1XGSA 2BWYA 3TB5A 2BHAA 5CDLA 2V3XA 1YVMA 3PKDA 2NQ7A 3MR1A 2G6PA 2OKNA 2OAZA 1QXZA 2BWVA 2GG2A 2V3YA 2EA2A 3Q6DA 2GU5A 5CNXA 4S2RP 4S2TP 1C22A 2P9AA 4ZWPA 2BWXA 4IDYA 4U71A 1N51A 3PN9A 2EA4A 4U6JA 4U6ZA 5JI6A 4U1BA 4U6CA 4U76A 1WL6A 5FCHA 4S00A 1YW8A 1R5GA 4S01A 1YJ3A 1YW7A 5JFRA 1R58A 2GG9A 2MATA 1XGMA 3S6BA 2GG3A 2BHBA 5D6FA 4FO8A 4FUKA 2GU6A 3FMQA 3IG4A 1KQ9A 1QXYA 3IU9A 2NQ6A 5CE6A 1BOAA 1KQ0A 4FLKA 1WKMA 1W2MA 2Q8KA 1WBQA 2B3LA 2GG5A 2Q95A 3CB5A 3OOOA 4IF7A 4KM3A 2GU7A 1WLRA 4IU6A 4HXXA 4B28A 2BHCA 1PV9A 4U69A 2HOWA 4FKCA 2BWTA 2P99A 4U75A 4IKTA 4A6WA 3L24A 4IECA 1KP0A 2V6CA 2B3HA 2IW2A 3FM3A 5JHUA 2BWUA 1C21A 1O0XA 3RORA 1WY2A 2GG8A 4PNCA 5E5BA 3PKBA 3IU8A 1C27A 1XGNA 3OVKA 2EVCA 1YW9A 2BB7A 3PKCA 5D6EA 1C23A 2GTXA 2Q96A 4A6VA 5CDVA 2BWWA 3PKAA 4IKUA 3PKEA 1QZYA 2GG0A 3D27A 2Q92A 3FMRA 3IL0A 1XNZA 1XGOA 2Q93A 3CTZA 1QXWA 3PEBA 3BITA 5CDEA 2DFIA 3IU7A 2GU4A 3BIPA 1C24A 5E2CA 1JAWA 5FCFA 5CLSA 4U6EA 4U6WA 4ZNGA 2GGCA 4FLJA 2EVMA 4RZYA 4FLLA 2GZ5A 4Z7MA 2EVOA 3QOCA 4OOKA 1B59A 2ZSGA 1Y1NA 4ZWUA 2B3KA 4PV4A 4ZWOA 3MATA 4FO7A 1CHMA 1W7VA 1M35A 4IPAA 2ADUA 2Q94A 4IKSA 2P98A 2GGBA 4EGEA 1A16A 2GG7A 4QR8A 4IKRA 2GA2A 3TAVA 3O5VA 2BH3A 2BWSA 4R60A 2BHDA 3MX6A 2V3ZA 1WN1A 4RZZA 1R5HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U73 A;  1BN5 A;  3BIQ A;  1MAT A;  5CIK A;  1WL9 A;  3I7M A;  3RVA A;  3CB6 A;  4U70 A;  4RGZ 1;  4MAT A;  4JUQ A;  2BN7 A;  1B6A A;  4FLI A;  3L7G A;  1XGS A;  2BWY A;  3TB5 A;  2BHA A;  5CDL A;  2V3X A;  1YVM A;  3PKD A;  2NQ7 A;  3MR1 A;  2G6P A;  2OKN A;  2OAZ A;  1QXZ A;  2BWV A;  2GG2 A;  2V3Y A;  2EA2 A;  3Q6D A;  2GU5 A;  5CNX A;  4S2R P;  4S2T P;  1C22 A;  2P9A A;  4ZWP A;  2BWX A;  4IDY A;  4U71 A;  1N51 A;  3PN9 A;  2EA4 A;  4U6J A;  4U6Z A;  5JI6 A;  4U1B A;  4U6C A;  4U76 A;  1WL6 A;  5FCH A;  4S00 A;  1YW8 A;  1R5G A;  4S01 A;  1YJ3 A;  1YW7 A;  5JFR A;  1R58 A;  2GG9 A;  2MAT A;  1XGM A;  3S6B A;  2GG3 A;  2BHB A;  5D6F A;  4FO8 A;  4FUK A;  2GU6 A;  3FMQ A;  3IG4 A;  1KQ9 A;  1QXY A;  3IU9 A;  2NQ6 A;  5CE6 A;  1BOA A;  1KQ0 A;  4FLK A;  1WKM A;  1W2M A;  2Q8K A;  1WBQ A;  2B3L A;  2GG5 A;  2Q95 A;  3CB5 A;  3OOO A;  4IF7 A;  4KM3 A;  2GU7 A;  1WLR A;  4IU6 A;  4HXX A;  4B28 A;  2BHC A;  1PV9 A;  4U69 A;  2HOW A;  4FKC A;  2BWT A;  2P99 A;  4U75 A;  4IKT A;  4A6W A;  3L24 A;  4IEC A;  1KP0 A;  2V6C A;  2B3H A;  2IW2 A;  3FM3 A;  5JHU A;  2BWU A;  1C21 A;  1O0X A;  3ROR A;  1WY2 A;  2GG8 A;  4PNC A;  5E5B A;  3PKB A;  3IU8 A;  1C27 A;  1XGN A;  3OVK A;  2EVC A;  1YW9 A;  2BB7 A;  3PKC A;  5D6E A;  1C23 A;  2GTX A;  2Q96 A;  4A6V A;  5CDV A;  2BWW A;  3PKA A;  4IKU A;  3PKE A;  1QZY A;  2GG0 A;  3D27 A;  2Q92 A;  3FMR A;  3IL0 A;  1XNZ A;  1XGO A;  2Q93 A;  3CTZ A;  1QXW A;  3PEB A;  3BIT A;  5CDE A;  2DFI A;  3IU7 A;  2GU4 A;  3BIP A;  1C24 A;  5E2C A;  1JAW A;  5FCF A;  5CLS A;  4U6E A;  4U6W A;  4ZNG A;  2GGC A;  4FLJ A;  2EVM A;  4RZY A;  4FLL A;  2GZ5 A;  4Z7M A;  2EVO A;  3QOC A;  4OOK A;  1B59 A;  2ZSG A;  1Y1N A;  4ZWU A;  2B3K A;  4PV4 A;  4ZWO A;  3MAT A;  4FO7 A;  1CHM A;  1W7V A;  1M35 A;  4IPA A;  2ADU A;  2Q94 A;  4IKS A;  2P98 A;  2GGB A;  4EGE A;  1A16 A;  2GG7 A;  4QR8 A;  4IKR A;  2GA2 A;  3TAV A;  3O5V A;  2BH3 A;  2BWS A;  4R60 A;  2BHD A;  3MX6 A;  2V3Z A;  1WN1 A;  4RZZ A;  1R5H A; 
#chains in the Genus database with same CATH topology
 4U73 A;  1BN5 A;  3BIQ A;  1MAT A;  5CIK A;  1WL9 A;  3I7M A;  3RVA A;  3CB6 A;  4U70 A;  4RGZ 1;  4MAT A;  4JUQ A;  2BN7 A;  1B6A A;  4FLI A;  3L7G A;  1XGS A;  2BWY A;  3TB5 A;  2BHA A;  5CDL A;  2V3X A;  1YVM A;  3PKD A;  2NQ7 A;  3MR1 A;  2G6P A;  2OKN A;  2OAZ A;  1QXZ A;  2BWV A;  2GG2 A;  2V3Y A;  2EA2 A;  3Q6D A;  2GU5 A;  5CNX A;  4S2R P;  4S2T P;  1C22 A;  2P9A A;  4ZWP A;  2BWX A;  4IDY A;  4U71 A;  1N51 A;  3PN9 A;  2EA4 A;  4U6J A;  4U6Z A;  5JI6 A;  4U1B A;  4U6C A;  4U76 A;  1WL6 A;  5FCH A;  4S00 A;  1YW8 A;  1R5G A;  4S01 A;  1YJ3 A;  1YW7 A;  5JFR A;  1R58 A;  2GG9 A;  2MAT A;  1XGM A;  3S6B A;  2GG3 A;  2BHB A;  5D6F A;  4FO8 A;  4FUK A;  2GU6 A;  3FMQ A;  3IG4 A;  1KQ9 A;  1QXY A;  3IU9 A;  2NQ6 A;  5CE6 A;  1BOA A;  1KQ0 A;  4FLK A;  1WKM A;  1W2M A;  2Q8K A;  1WBQ A;  2B3L A;  2GG5 A;  2Q95 A;  3CB5 A;  3OOO A;  4IF7 A;  4KM3 A;  2GU7 A;  1WLR A;  4IU6 A;  4HXX A;  4B28 A;  2BHC A;  1PV9 A;  4U69 A;  2HOW A;  4FKC A;  2BWT A;  2P99 A;  4U75 A;  4IKT A;  4A6W A;  3L24 A;  4IEC A;  1KP0 A;  2V6C A;  2B3H A;  2IW2 A;  3FM3 A;  5JHU A;  2BWU A;  1C21 A;  1O0X A;  3ROR A;  1WY2 A;  2GG8 A;  4PNC A;  5E5B A;  3PKB A;  3IU8 A;  1C27 A;  1XGN A;  3OVK A;  2EVC A;  1YW9 A;  2BB7 A;  3PKC A;  5D6E A;  1C23 A;  2GTX A;  2Q96 A;  4A6V A;  5CDV A;  2BWW A;  3PKA A;  4IKU A;  3PKE A;  1QZY A;  2GG0 A;  3D27 A;  2Q92 A;  3FMR A;  3IL0 A;  1XNZ A;  1XGO A;  2Q93 A;  3CTZ A;  1QXW A;  3PEB A;  3BIT A;  5CDE A;  2DFI A;  3IU7 A;  2GU4 A;  3BIP A;  1C24 A;  5E2C A;  1JAW A;  5FCF A;  5CLS A;  4U6E A;  4U6W A;  4ZNG A;  2GGC A;  4FLJ A;  2EVM A;  4RZY A;  4FLL A;  2GZ5 A;  4Z7M A;  2EVO A;  3QOC A;  4OOK A;  1B59 A;  2ZSG A;  1Y1N A;  4ZWU A;  2B3K A;  4PV4 A;  4ZWO A;  3MAT A;  4FO7 A;  1CHM A;  1W7V A;  1M35 A;  4IPA A;  2ADU A;  2Q94 A;  4IKS A;  2P98 A;  2GGB A;  4EGE A;  1A16 A;  2GG7 A;  4QR8 A;  4IKR A;  2GA2 A;  3TAV A;  3O5V A;  2BH3 A;  2BWS A;  4R60 A;  2BHD A;  3MX6 A;  2V3Z A;  1WN1 A;  4RZZ A;  1R5H A; 
#chains in the Genus database with same CATH homology
 4U73 A;  1BN5 A;  3BIQ A;  1MAT A;  5CIK A;  1WL9 A;  3I7M A;  3RVA A;  3CB6 A;  4U70 A;  4RGZ 1;  4MAT A;  4JUQ A;  2BN7 A;  1B6A A;  4FLI A;  3L7G A;  1XGS A;  2BWY A;  3TB5 A;  2BHA A;  5CDL A;  2V3X A;  1YVM A;  3PKD A;  2NQ7 A;  3MR1 A;  2G6P A;  2OKN A;  2OAZ A;  1QXZ A;  2BWV A;  2GG2 A;  2V3Y A;  2EA2 A;  3Q6D A;  2GU5 A;  5CNX A;  4S2R P;  4S2T P;  1C22 A;  2P9A A;  4ZWP A;  2BWX A;  4IDY A;  4U71 A;  1N51 A;  3PN9 A;  2EA4 A;  4U6J A;  4U6Z A;  5JI6 A;  4U1B A;  4U6C A;  4U76 A;  1WL6 A;  5FCH A;  4S00 A;  1YW8 A;  1R5G A;  4S01 A;  1YJ3 A;  1YW7 A;  5JFR A;  1R58 A;  2GG9 A;  2MAT A;  1XGM A;  3S6B A;  2GG3 A;  2BHB A;  5D6F A;  4FO8 A;  4FUK A;  2GU6 A;  3FMQ A;  3IG4 A;  1KQ9 A;  1QXY A;  3IU9 A;  2NQ6 A;  5CE6 A;  1BOA A;  1KQ0 A;  4FLK A;  1WKM A;  1W2M A;  2Q8K A;  1WBQ A;  2B3L A;  2GG5 A;  2Q95 A;  3CB5 A;  3OOO A;  4IF7 A;  4KM3 A;  2GU7 A;  1WLR A;  4IU6 A;  4HXX A;  4B28 A;  2BHC A;  1PV9 A;  4U69 A;  2HOW A;  4FKC A;  2BWT A;  2P99 A;  4U75 A;  4IKT A;  4A6W A;  3L24 A;  4IEC A;  1KP0 A;  2V6C A;  2B3H A;  2IW2 A;  3FM3 A;  5JHU A;  2BWU A;  1C21 A;  1O0X A;  3ROR A;  1WY2 A;  2GG8 A;  4PNC A;  5E5B A;  3PKB A;  3IU8 A;  1C27 A;  1XGN A;  3OVK A;  2EVC A;  1YW9 A;  2BB7 A;  3PKC A;  5D6E A;  1C23 A;  2GTX A;  2Q96 A;  4A6V A;  5CDV A;  2BWW A;  3PKA A;  4IKU A;  3PKE A;  1QZY A;  2GG0 A;  3D27 A;  2Q92 A;  3FMR A;  3IL0 A;  1XNZ A;  1XGO A;  2Q93 A;  3CTZ A;  1QXW A;  3PEB A;  3BIT A;  5CDE A;  2DFI A;  3IU7 A;  2GU4 A;  3BIP A;  1C24 A;  5E2C A;  1JAW A;  5FCF A;  5CLS A;  4U6E A;  4U6W A;  4ZNG A;  2GGC A;  4FLJ A;  2EVM A;  4RZY A;  4FLL A;  2GZ5 A;  4Z7M A;  2EVO A;  3QOC A;  4OOK A;  1B59 A;  2ZSG A;  1Y1N A;  4ZWU A;  2B3K A;  4PV4 A;  4ZWO A;  3MAT A;  4FO7 A;  1CHM A;  1W7V A;  1M35 A;  4IPA A;  2ADU A;  2Q94 A;  4IKS A;  2P98 A;  2GGB A;  4EGE A;  1A16 A;  2GG7 A;  4QR8 A;  4IKR A;  2GA2 A;  3TAV A;  3O5V A;  2BH3 A;  2BWS A;  4R60 A;  2BHD A;  3MX6 A;  2V3Z A;  1WN1 A;  4RZZ A;  1R5H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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