4IU6A

Human methionine aminopeptidase in complex with fz1: pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
publication title Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2013-01-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF15801 zf-C6H2 zf-MYND-like zinc finger, mRNA-binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4iu6A00
1WN1A 1N51A 4S2RP 2OKNA 2EA2A 2Q95A 2EVOA 5CE6A 2BWSA 2B3LA 4U6EA 2BWWA 2NQ7A 1XGOA 4FLIA 4RZZA 3CB5A 5FCHA 1XNZA 2BHCA 3D27A 3PKCA 4IECA 2P98A 1JAWA 1B6AA 1XGNA 2BWVA 1BOAA 3S6BA 2GA2A 4ZWOA 4U6ZA 2BHDA 2HOWA 2B3HA 4S2TP 2ZSGA 5CIKA 4IDYA 5JHUA 5FCFA 1QXWA 2GU4A 2GZ5A 3RVAA 4B28A 1BN5A 4RZYA 3TB5A 1YW7A 2GG7A 1W2MA 3BIQA 1W7VA 3PKAA 4PNCA 1PV9A 2GU5A 4PV4A 2BHAA 1QXYA 3BITA 1C21A 5CDEA 3IG4A 3CTZA 4U73A 4R60A 2V3ZA 4RGZ1 5E5BA 4A6WA 3TAVA 4IPAA 1R5HA 2GG2A 3PKDA 4U6JA 3PKBA 2OAZA 1Y1NA 2V3YA 2P9AA 4U75A 1C27A 4IF7A 3FMRA 1R58A 1KQ0A 4S00A 4OOKA 4U6WA 1MATA 5D6FA 2Q93A 4IKUA 2Q92A 1WL9A 4S01A 2GU6A 4FO8A 2BH3A 2B3KA 1R5GA 5JI6A 2EVCA 4FLKA 1CHMA 2G6PA 4HXXA 3MX6A 3Q6DA 2GG9A 2BB7A 2BWTA 3FM3A 4U1BA 3RORA 4FUKA 3PKEA 4IKRA 4EGEA 4ZNGA 2P99A 1WBQA 3BIPA 4U70A 2GG0A 1A16A 3CB6A 4U6CA 5CNXA 1WL6A 3MATA 1WKMA 2Q94A 2BWYA 1YW9A 4FKCA 2BWUA 1M35A 4U71A 3L7GA 4FO7A 2Q96A 2GG3A 4IU6A 5JFRA 1YJ3A 1QZYA 1B59A 5CLSA 4FLJA 3MR1A 1XGMA 2IW2A 1O0XA 2NQ6A 1C24A 5CDLA 2GGBA 2V6CA 4JUQA 2MATA 5CDVA 2GTXA 1WLRA 2DFIA 4Z7MA 2EA4A 1C22A 1KQ9A 3IU9A 3L24A 4QR8A 5D6EA 2BWXA 1XGSA 3FMQA 4FLLA 3IU7A 1WY2A 4ZWPA 2V3XA 2ADUA 4A6VA 2EVMA 2GGCA 4MATA 4IKTA 4ZWUA 4U69A 2GG8A 4KM3A 1YW8A 1YVMA 2BHBA 4U76A 1C23A 1QXZA 2GU7A 3IU8A 4IKSA 2BN7A 2Q8KA 2GG5A 1KP0A
chains in the Genus database with same CATH superfamily
1WN1A 1N51A 4S2RP 2OKNA 2EA2A 2Q95A 2EVOA 5CE6A 2BWSA 2B3LA 4U6EA 2BWWA 2NQ7A 1XGOA 4FLIA 4RZZA 3CB5A 5FCHA 1XNZA 2BHCA 3D27A 3PKCA 4IECA 2P98A 1JAWA 1B6AA 1XGNA 2BWVA 1BOAA 3S6BA 2GA2A 4ZWOA 4U6ZA 2BHDA 2HOWA 2B3HA 4S2TP 2ZSGA 5CIKA 4IDYA 5JHUA 5FCFA 1QXWA 2GU4A 2GZ5A 3RVAA 4B28A 1BN5A 4RZYA 3TB5A 1YW7A 2GG7A 1W2MA 3BIQA 1W7VA 3PKAA 4PNCA 1PV9A 2GU5A 4PV4A 2BHAA 1QXYA 3BITA 1C21A 5CDEA 3IG4A 3CTZA 4U73A 4R60A 2V3ZA 4RGZ1 5E5BA 4A6WA 3TAVA 4IPAA 1R5HA 2GG2A 3PKDA 4U6JA 3PKBA 2OAZA 1Y1NA 2V3YA 2P9AA 4U75A 1C27A 4IF7A 3FMRA 1R58A 1KQ0A 4S00A 4OOKA 4U6WA 1MATA 5D6FA 2Q93A 4IKUA 2Q92A 1WL9A 4S01A 2GU6A 4FO8A 2BH3A 2B3KA 1R5GA 5JI6A 2EVCA 4FLKA 1CHMA 2G6PA 4HXXA 3MX6A 3Q6DA 2GG9A 2BB7A 2BWTA 3FM3A 4U1BA 3RORA 4FUKA 3PKEA 4IKRA 4EGEA 4ZNGA 2P99A 1WBQA 3BIPA 4U70A 2GG0A 1A16A 3CB6A 4U6CA 5CNXA 1WL6A 3MATA 1WKMA 2Q94A 2BWYA 1YW9A 4FKCA 2BWUA 1M35A 4U71A 3L7GA 4FO7A 2Q96A 2GG3A 4IU6A 5JFRA 1YJ3A 1QZYA 1B59A 5CLSA 4FLJA 3MR1A 1XGMA 2IW2A 1O0XA 2NQ6A 1C24A 5CDLA 2GGBA 2V6CA 4JUQA 2MATA 5CDVA 2GTXA 1WLRA 2DFIA 4Z7MA 2EA4A 1C22A 1KQ9A 3IU9A 3L24A 4QR8A 5D6EA 2BWXA 1XGSA 3FMQA 4FLLA 3IU7A 1WY2A 4ZWPA 2V3XA 2ADUA 4A6VA 2EVMA 2GGCA 4MATA 4IKTA 4ZWUA 4U69A 2GG8A 4KM3A 1YW8A 1YVMA 2BHBA 4U76A 1C23A 1QXZA 2GU7A 3IU8A 4IKSA 2BN7A 2Q8KA 2GG5A 1KP0A
chains in the Genus database with same CATH topology
1WN1A 1N51A 4S2RP 2OKNA 2EA2A 2Q95A 2EVOA 5CE6A 2BWSA 2B3LA 4U6EA 2BWWA 2NQ7A 1XGOA 4FLIA 4RZZA 3CB5A 5FCHA 1XNZA 2BHCA 3D27A 3PKCA 4IECA 2P98A 1JAWA 1B6AA 1XGNA 2BWVA 1BOAA 3S6BA 2GA2A 4ZWOA 4U6ZA 2BHDA 2HOWA 2B3HA 4S2TP 2ZSGA 5CIKA 4IDYA 5JHUA 5FCFA 1QXWA 2GU4A 2GZ5A 3RVAA 4B28A 1BN5A 4RZYA 3TB5A 1YW7A 2GG7A 1W2MA 3BIQA 1W7VA 3PKAA 4PNCA 1PV9A 2GU5A 4PV4A 2BHAA 1QXYA 3BITA 1C21A 5CDEA 3IG4A 3CTZA 4U73A 4R60A 2V3ZA 4RGZ1 5E5BA 4A6WA 3TAVA 4IPAA 1R5HA 2GG2A 3PKDA 4U6JA 3PKBA 2OAZA 1Y1NA 2V3YA 2P9AA 4U75A 1C27A 4IF7A 3FMRA 1R58A 1KQ0A 4S00A 4OOKA 4U6WA 1MATA 5D6FA 2Q93A 4IKUA 2Q92A 1WL9A 4S01A 2GU6A 4FO8A 2BH3A 2B3KA 1R5GA 5JI6A 2EVCA 4FLKA 1CHMA 2G6PA 4HXXA 3MX6A 3Q6DA 2GG9A 2BB7A 2BWTA 3FM3A 4U1BA 3RORA 4FUKA 3PKEA 4IKRA 4EGEA 4ZNGA 2P99A 1WBQA 3BIPA 4U70A 2GG0A 1A16A 3CB6A 4U6CA 5CNXA 1WL6A 3MATA 1WKMA 2Q94A 2BWYA 1YW9A 4FKCA 2BWUA 1M35A 4U71A 3L7GA 4FO7A 2Q96A 2GG3A 4IU6A 5JFRA 1YJ3A 1QZYA 1B59A 5CLSA 4FLJA 3MR1A 1XGMA 2IW2A 1O0XA 2NQ6A 1C24A 5CDLA 2GGBA 2V6CA 4JUQA 2MATA 5CDVA 2GTXA 1WLRA 2DFIA 4Z7MA 2EA4A 1C22A 1KQ9A 3IU9A 3L24A 4QR8A 5D6EA 2BWXA 1XGSA 3FMQA 4FLLA 3IU7A 1WY2A 4ZWPA 2V3XA 2ADUA 4A6VA 2EVMA 2GGCA 4MATA 4IKTA 4ZWUA 4U69A 2GG8A 4KM3A 1YW8A 1YVMA 2BHBA 4U76A 1C23A 1QXZA 2GU7A 3IU8A 4IKSA 2BN7A 2Q8KA 2GG5A 1KP0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WN1 A;  1N51 A;  4S2R P;  2OKN A;  2EA2 A;  2Q95 A;  2EVO A;  5CE6 A;  2BWS A;  2B3L A;  4U6E A;  2BWW A;  2NQ7 A;  1XGO A;  4FLI A;  4RZZ A;  3CB5 A;  5FCH A;  1XNZ A;  2BHC A;  3D27 A;  3PKC A;  4IEC A;  2P98 A;  1JAW A;  1B6A A;  1XGN A;  2BWV A;  1BOA A;  3S6B A;  2GA2 A;  4ZWO A;  4U6Z A;  2BHD A;  2HOW A;  2B3H A;  4S2T P;  2ZSG A;  5CIK A;  4IDY A;  5JHU A;  5FCF A;  1QXW A;  2GU4 A;  2GZ5 A;  3RVA A;  4B28 A;  1BN5 A;  4RZY A;  3TB5 A;  1YW7 A;  2GG7 A;  1W2M A;  3BIQ A;  1W7V A;  3PKA A;  4PNC A;  1PV9 A;  2GU5 A;  4PV4 A;  2BHA A;  1QXY A;  3BIT A;  1C21 A;  5CDE A;  3IG4 A;  3CTZ A;  4U73 A;  4R60 A;  2V3Z A;  4RGZ 1;  5E5B A;  4A6W A;  3TAV A;  4IPA A;  1R5H A;  2GG2 A;  3PKD A;  4U6J A;  3PKB A;  2OAZ A;  1Y1N A;  2V3Y A;  2P9A A;  4U75 A;  1C27 A;  4IF7 A;  3FMR A;  1R58 A;  1KQ0 A;  4S00 A;  4OOK A;  4U6W A;  1MAT A;  5D6F A;  2Q93 A;  4IKU A;  2Q92 A;  1WL9 A;  4S01 A;  2GU6 A;  4FO8 A;  2BH3 A;  2B3K A;  1R5G A;  5JI6 A;  2EVC A;  4FLK A;  1CHM A;  2G6P A;  4HXX A;  3MX6 A;  3Q6D A;  2GG9 A;  2BB7 A;  2BWT A;  3FM3 A;  4U1B A;  3ROR A;  4FUK A;  3PKE A;  4IKR A;  4EGE A;  4ZNG A;  2P99 A;  1WBQ A;  3BIP A;  4U70 A;  2GG0 A;  1A16 A;  3CB6 A;  4U6C A;  5CNX A;  1WL6 A;  3MAT A;  1WKM A;  2Q94 A;  2BWY A;  1YW9 A;  4FKC A;  2BWU A;  1M35 A;  4U71 A;  3L7G A;  4FO7 A;  2Q96 A;  2GG3 A;  4IU6 A;  5JFR A;  1YJ3 A;  1QZY A;  1B59 A;  5CLS A;  4FLJ A;  3MR1 A;  1XGM A;  2IW2 A;  1O0X A;  2NQ6 A;  1C24 A;  5CDL A;  2GGB A;  2V6C A;  4JUQ A;  2MAT A;  5CDV A;  2GTX A;  1WLR A;  2DFI A;  4Z7M A;  2EA4 A;  1C22 A;  1KQ9 A;  3IU9 A;  3L24 A;  4QR8 A;  5D6E A;  2BWX A;  1XGS A;  3FMQ A;  4FLL A;  3IU7 A;  1WY2 A;  4ZWP A;  2V3X A;  2ADU A;  4A6V A;  2EVM A;  2GGC A;  4MAT A;  4IKT A;  4ZWU A;  4U69 A;  2GG8 A;  4KM3 A;  1YW8 A;  1YVM A;  2BHB A;  4U76 A;  1C23 A;  1QXZ A;  2GU7 A;  3IU8 A;  4IKS A;  2BN7 A;  2Q8K A;  2GG5 A;  1KP0 A; 
#chains in the Genus database with same CATH topology
 1WN1 A;  1N51 A;  4S2R P;  2OKN A;  2EA2 A;  2Q95 A;  2EVO A;  5CE6 A;  2BWS A;  2B3L A;  4U6E A;  2BWW A;  2NQ7 A;  1XGO A;  4FLI A;  4RZZ A;  3CB5 A;  5FCH A;  1XNZ A;  2BHC A;  3D27 A;  3PKC A;  4IEC A;  2P98 A;  1JAW A;  1B6A A;  1XGN A;  2BWV A;  1BOA A;  3S6B A;  2GA2 A;  4ZWO A;  4U6Z A;  2BHD A;  2HOW A;  2B3H A;  4S2T P;  2ZSG A;  5CIK A;  4IDY A;  5JHU A;  5FCF A;  1QXW A;  2GU4 A;  2GZ5 A;  3RVA A;  4B28 A;  1BN5 A;  4RZY A;  3TB5 A;  1YW7 A;  2GG7 A;  1W2M A;  3BIQ A;  1W7V A;  3PKA A;  4PNC A;  1PV9 A;  2GU5 A;  4PV4 A;  2BHA A;  1QXY A;  3BIT A;  1C21 A;  5CDE A;  3IG4 A;  3CTZ A;  4U73 A;  4R60 A;  2V3Z A;  4RGZ 1;  5E5B A;  4A6W A;  3TAV A;  4IPA A;  1R5H A;  2GG2 A;  3PKD A;  4U6J A;  3PKB A;  2OAZ A;  1Y1N A;  2V3Y A;  2P9A A;  4U75 A;  1C27 A;  4IF7 A;  3FMR A;  1R58 A;  1KQ0 A;  4S00 A;  4OOK A;  4U6W A;  1MAT A;  5D6F A;  2Q93 A;  4IKU A;  2Q92 A;  1WL9 A;  4S01 A;  2GU6 A;  4FO8 A;  2BH3 A;  2B3K A;  1R5G A;  5JI6 A;  2EVC A;  4FLK A;  1CHM A;  2G6P A;  4HXX A;  3MX6 A;  3Q6D A;  2GG9 A;  2BB7 A;  2BWT A;  3FM3 A;  4U1B A;  3ROR A;  4FUK A;  3PKE A;  4IKR A;  4EGE A;  4ZNG A;  2P99 A;  1WBQ A;  3BIP A;  4U70 A;  2GG0 A;  1A16 A;  3CB6 A;  4U6C A;  5CNX A;  1WL6 A;  3MAT A;  1WKM A;  2Q94 A;  2BWY A;  1YW9 A;  4FKC A;  2BWU A;  1M35 A;  4U71 A;  3L7G A;  4FO7 A;  2Q96 A;  2GG3 A;  4IU6 A;  5JFR A;  1YJ3 A;  1QZY A;  1B59 A;  5CLS A;  4FLJ A;  3MR1 A;  1XGM A;  2IW2 A;  1O0X A;  2NQ6 A;  1C24 A;  5CDL A;  2GGB A;  2V6C A;  4JUQ A;  2MAT A;  5CDV A;  2GTX A;  1WLR A;  2DFI A;  4Z7M A;  2EA4 A;  1C22 A;  1KQ9 A;  3IU9 A;  3L24 A;  4QR8 A;  5D6E A;  2BWX A;  1XGS A;  3FMQ A;  4FLL A;  3IU7 A;  1WY2 A;  4ZWP A;  2V3X A;  2ADU A;  4A6V A;  2EVM A;  2GGC A;  4MAT A;  4IKT A;  4ZWU A;  4U69 A;  2GG8 A;  4KM3 A;  1YW8 A;  1YVM A;  2BHB A;  4U76 A;  1C23 A;  1QXZ A;  2GU7 A;  3IU8 A;  4IKS A;  2BN7 A;  2Q8K A;  2GG5 A;  1KP0 A; 
#chains in the Genus database with same CATH homology
 1WN1 A;  1N51 A;  4S2R P;  2OKN A;  2EA2 A;  2Q95 A;  2EVO A;  5CE6 A;  2BWS A;  2B3L A;  4U6E A;  2BWW A;  2NQ7 A;  1XGO A;  4FLI A;  4RZZ A;  3CB5 A;  5FCH A;  1XNZ A;  2BHC A;  3D27 A;  3PKC A;  4IEC A;  2P98 A;  1JAW A;  1B6A A;  1XGN A;  2BWV A;  1BOA A;  3S6B A;  2GA2 A;  4ZWO A;  4U6Z A;  2BHD A;  2HOW A;  2B3H A;  4S2T P;  2ZSG A;  5CIK A;  4IDY A;  5JHU A;  5FCF A;  1QXW A;  2GU4 A;  2GZ5 A;  3RVA A;  4B28 A;  1BN5 A;  4RZY A;  3TB5 A;  1YW7 A;  2GG7 A;  1W2M A;  3BIQ A;  1W7V A;  3PKA A;  4PNC A;  1PV9 A;  2GU5 A;  4PV4 A;  2BHA A;  1QXY A;  3BIT A;  1C21 A;  5CDE A;  3IG4 A;  3CTZ A;  4U73 A;  4R60 A;  2V3Z A;  4RGZ 1;  5E5B A;  4A6W A;  3TAV A;  4IPA A;  1R5H A;  2GG2 A;  3PKD A;  4U6J A;  3PKB A;  2OAZ A;  1Y1N A;  2V3Y A;  2P9A A;  4U75 A;  1C27 A;  4IF7 A;  3FMR A;  1R58 A;  1KQ0 A;  4S00 A;  4OOK A;  4U6W A;  1MAT A;  5D6F A;  2Q93 A;  4IKU A;  2Q92 A;  1WL9 A;  4S01 A;  2GU6 A;  4FO8 A;  2BH3 A;  2B3K A;  1R5G A;  5JI6 A;  2EVC A;  4FLK A;  1CHM A;  2G6P A;  4HXX A;  3MX6 A;  3Q6D A;  2GG9 A;  2BB7 A;  2BWT A;  3FM3 A;  4U1B A;  3ROR A;  4FUK A;  3PKE A;  4IKR A;  4EGE A;  4ZNG A;  2P99 A;  1WBQ A;  3BIP A;  4U70 A;  2GG0 A;  1A16 A;  3CB6 A;  4U6C A;  5CNX A;  1WL6 A;  3MAT A;  1WKM A;  2Q94 A;  2BWY A;  1YW9 A;  4FKC A;  2BWU A;  1M35 A;  4U71 A;  3L7G A;  4FO7 A;  2Q96 A;  2GG3 A;  4IU6 A;  5JFR A;  1YJ3 A;  1QZY A;  1B59 A;  5CLS A;  4FLJ A;  3MR1 A;  1XGM A;  2IW2 A;  1O0X A;  2NQ6 A;  1C24 A;  5CDL A;  2GGB A;  2V6C A;  4JUQ A;  2MAT A;  5CDV A;  2GTX A;  1WLR A;  2DFI A;  4Z7M A;  2EA4 A;  1C22 A;  1KQ9 A;  3IU9 A;  3L24 A;  4QR8 A;  5D6E A;  2BWX A;  1XGS A;  3FMQ A;  4FLL A;  3IU7 A;  1WY2 A;  4ZWP A;  2V3X A;  2ADU A;  4A6V A;  2EVM A;  2GGC A;  4MAT A;  4IKT A;  4ZWU A;  4U69 A;  2GG8 A;  4KM3 A;  1YW8 A;  1YVM A;  2BHB A;  4U76 A;  1C23 A;  1QXZ A;  2GU7 A;  3IU8 A;  4IKS A;  2BN7 A;  2Q8K A;  2GG5 A;  1KP0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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