4ZWOA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 158
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
sequence length
439
structure length
425
Chain Sequence
NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule keywords organophosphate anhydrolase/prolidase
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
total genus 158
structure length 425
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwoA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwoA02
2B3LA 2EVOA 2GU7A 3PKEA 4S00A 4U1BA 4ZWOA 3L7GA 2BHAA 2BN7A 1W7VA 3FMQA 2P98A 3L24A 4HXXA 4U6JA 1BOAA 4U76A 2EA4A 2GGBA 2BWTA 2BWSA 5E2CA 4FUKA 1YW8A 1WY2A 2OKNA 1C23A 2GG0A 3MX6A 2Q94A 4Z7MA 2GG8A 3PEBA 1C27A 4RZZA 4MATA 1WKMA 5CE6A 1C24A 1QXZA 2OAZA 2Q93A 3OOOA 1XGSA 2MATA 4FLJA 4EGEA 2EVCA 2GG3A 4IKTA 4U71A 2GU4A 3TB5A 2P9AA 5FCFA 1R5GA 2Q96A 3CB6A 2GZ5A 3S6BA 2BHBA 4S01A 3BIQA 1R58A 3CTZA 4FO8A 4PNCA 3TAVA 2HOWA 4S2RP 2ZSGA 4IKSA 4U73A 4FLIA 3PKDA 5JHUA 2V6CA 2BWUA 4IF7A 2GG5A 2BB7A 2BH3A 5CIKA 5D6FA 1MATA 2ADUA 4U69A 3IU7A 2P99A 4IU6A 2BHCA 1M35A 4QR8A 4FLKA 5E5BA 1YJ3A 4RGZ1 4IKUA 2BWVA 3PN9A 4ZWPA 4JUQA 2DFIA 4IDYA 3Q6DA 4S2TP 3IU8A 1N51A 2Q92A 1WBQA 3OVKA 1BN5A 1QXYA 4KM3A 4U6CA 4U70A 2BWYA 4FO7A 5CDVA 2GTXA 4B28A 3O5VA 3RVAA 5JFRA 1C21A 4ZNGA 4IECA 3PKCA 1Y1NA 2Q8KA 4PV4A 1CHMA 5JI6A 2GG2A 4IPAA 3D27A 3IL0A 2BHDA 1B59A 1R5HA 3QOCA 3IU9A 3I7MA 2B3KA 1WLRA 3FM3A 2NQ7A 1WN1A 4ZWUA 1YW7A 1XGOA 4IKRA 2GA2A 1XNZA 1B6AA 1KP0A 2IW2A 1O0XA 2EVMA 2GU6A 1KQ9A 4A6VA 1YVMA 4FLLA 3PKBA 4U75A 5CDEA 1QZYA 5CDLA 1WL6A 1XGNA 1A16A 2G6PA 1XGMA 1PV9A 5FCHA 4U6ZA 5D6EA 3MR1A 3RORA 2GU5A 1C22A 3BIPA 2NQ6A 1WL9A 2B3HA 3FMRA 2EA2A 5CLSA 4RZYA 2GG7A 3MATA 2V3ZA 3IG4A 4U6EA 4R60A 4OOKA 3BITA 4A6WA 2BWWA 2BWXA 2Q95A 1JAWA 2V3XA 3PKAA 1KQ0A 4FKCA 5CNXA 2V3YA 2GG9A 1YW9A 3CB5A 2GGCA 1W2MA 4U6WA 1QXWA
chains in the Genus database with same CATH superfamily
2B3LA 2EVOA 2GU7A 3PKEA 4S00A 4U1BA 4ZWOA 3L7GA 2BHAA 2BN7A 1W7VA 3FMQA 2P98A 3L24A 4HXXA 4U6JA 1BOAA 4U76A 2EA4A 2GGBA 2BWTA 2BWSA 5E2CA 4FUKA 1YW8A 1WY2A 2OKNA 1C23A 2GG0A 3MX6A 2Q94A 4Z7MA 2GG8A 3PEBA 1C27A 4RZZA 4MATA 1WKMA 5CE6A 1C24A 1QXZA 2OAZA 2Q93A 3OOOA 1XGSA 2MATA 4FLJA 4EGEA 2EVCA 2GG3A 4IKTA 4U71A 2GU4A 3TB5A 2P9AA 5FCFA 1R5GA 2Q96A 3CB6A 2GZ5A 3S6BA 2BHBA 4S01A 3BIQA 1R58A 3CTZA 4FO8A 4PNCA 3TAVA 2HOWA 4S2RP 2ZSGA 4IKSA 4U73A 4FLIA 3PKDA 5JHUA 2V6CA 2BWUA 4IF7A 2GG5A 2BB7A 2BH3A 5CIKA 5D6FA 1MATA 2ADUA 4U69A 3IU7A 2P99A 4IU6A 2BHCA 1M35A 4QR8A 4FLKA 5E5BA 1YJ3A 4RGZ1 4IKUA 2BWVA 3PN9A 4ZWPA 4JUQA 2DFIA 4IDYA 3Q6DA 4S2TP 3IU8A 1N51A 2Q92A 1WBQA 3OVKA 1BN5A 1QXYA 4KM3A 4U6CA 4U70A 2BWYA 4FO7A 5CDVA 2GTXA 4B28A 3O5VA 3RVAA 5JFRA 1C21A 4ZNGA 4IECA 3PKCA 1Y1NA 2Q8KA 4PV4A 1CHMA 5JI6A 2GG2A 4IPAA 3D27A 3IL0A 2BHDA 1B59A 1R5HA 3QOCA 3IU9A 3I7MA 2B3KA 1WLRA 3FM3A 2NQ7A 1WN1A 4ZWUA 1YW7A 1XGOA 4IKRA 2GA2A 1XNZA 1B6AA 1KP0A 2IW2A 1O0XA 2EVMA 2GU6A 1KQ9A 4A6VA 1YVMA 4FLLA 3PKBA 4U75A 5CDEA 1QZYA 5CDLA 1WL6A 1XGNA 1A16A 2G6PA 1XGMA 1PV9A 5FCHA 4U6ZA 5D6EA 3MR1A 3RORA 2GU5A 1C22A 3BIPA 2NQ6A 1WL9A 2B3HA 3FMRA 2EA2A 5CLSA 4RZYA 2GG7A 3MATA 2V3ZA 3IG4A 4U6EA 4R60A 4OOKA 3BITA 4A6WA 2BWWA 2BWXA 2Q95A 1JAWA 2V3XA 3PKAA 1KQ0A 4FKCA 5CNXA 2V3YA 2GG9A 1YW9A 3CB5A 2GGCA 1W2MA 4U6WA 1QXWA
chains in the Genus database with same CATH topology
2B3LA 2EVOA 2GU7A 3PKEA 4S00A 4U1BA 4ZWOA 3L7GA 2BHAA 2BN7A 1W7VA 3FMQA 2P98A 3L24A 4HXXA 4U6JA 1BOAA 4U76A 2EA4A 2GGBA 2BWTA 2BWSA 5E2CA 4FUKA 1YW8A 1WY2A 2OKNA 1C23A 2GG0A 3MX6A 2Q94A 4Z7MA 2GG8A 3PEBA 1C27A 4RZZA 4MATA 1WKMA 5CE6A 1C24A 1QXZA 2OAZA 2Q93A 3OOOA 1XGSA 2MATA 4FLJA 4EGEA 2EVCA 2GG3A 4IKTA 4U71A 2GU4A 3TB5A 2P9AA 5FCFA 1R5GA 2Q96A 3CB6A 2GZ5A 3S6BA 2BHBA 4S01A 3BIQA 1R58A 3CTZA 4FO8A 4PNCA 3TAVA 2HOWA 4S2RP 2ZSGA 4IKSA 4U73A 4FLIA 3PKDA 5JHUA 2V6CA 2BWUA 4IF7A 2GG5A 2BB7A 2BH3A 5CIKA 5D6FA 1MATA 2ADUA 4U69A 3IU7A 2P99A 4IU6A 2BHCA 1M35A 4QR8A 4FLKA 5E5BA 1YJ3A 4RGZ1 4IKUA 2BWVA 3PN9A 4ZWPA 4JUQA 2DFIA 4IDYA 3Q6DA 4S2TP 3IU8A 1N51A 2Q92A 1WBQA 3OVKA 1BN5A 1QXYA 4KM3A 4U6CA 4U70A 2BWYA 4FO7A 5CDVA 2GTXA 4B28A 3O5VA 3RVAA 5JFRA 1C21A 4ZNGA 4IECA 3PKCA 1Y1NA 2Q8KA 4PV4A 1CHMA 5JI6A 2GG2A 4IPAA 3D27A 3IL0A 2BHDA 1B59A 1R5HA 3QOCA 3IU9A 3I7MA 2B3KA 1WLRA 3FM3A 2NQ7A 1WN1A 4ZWUA 1YW7A 1XGOA 4IKRA 2GA2A 1XNZA 1B6AA 1KP0A 2IW2A 1O0XA 2EVMA 2GU6A 1KQ9A 4A6VA 1YVMA 4FLLA 3PKBA 4U75A 5CDEA 1QZYA 5CDLA 1WL6A 1XGNA 1A16A 2G6PA 1XGMA 1PV9A 5FCHA 4U6ZA 5D6EA 3MR1A 3RORA 2GU5A 1C22A 3BIPA 2NQ6A 1WL9A 2B3HA 3FMRA 2EA2A 5CLSA 4RZYA 2GG7A 3MATA 2V3ZA 3IG4A 4U6EA 4R60A 4OOKA 3BITA 4A6WA 2BWWA 2BWXA 2Q95A 1JAWA 2V3XA 3PKAA 1KQ0A 4FKCA 5CNXA 2V3YA 2GG9A 1YW9A 3CB5A 2GGCA 1W2MA 4U6WA 1QXWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B3L A;  2EVO A;  2GU7 A;  3PKE A;  4S00 A;  4U1B A;  4ZWO A;  3L7G A;  2BHA A;  2BN7 A;  1W7V A;  3FMQ A;  2P98 A;  3L24 A;  4HXX A;  4U6J A;  1BOA A;  4U76 A;  2EA4 A;  2GGB A;  2BWT A;  2BWS A;  5E2C A;  4FUK A;  1YW8 A;  1WY2 A;  2OKN A;  1C23 A;  2GG0 A;  3MX6 A;  2Q94 A;  4Z7M A;  2GG8 A;  3PEB A;  1C27 A;  4RZZ A;  4MAT A;  1WKM A;  5CE6 A;  1C24 A;  1QXZ A;  2OAZ A;  2Q93 A;  3OOO A;  1XGS A;  2MAT A;  4FLJ A;  4EGE A;  2EVC A;  2GG3 A;  4IKT A;  4U71 A;  2GU4 A;  3TB5 A;  2P9A A;  5FCF A;  1R5G A;  2Q96 A;  3CB6 A;  2GZ5 A;  3S6B A;  2BHB A;  4S01 A;  3BIQ A;  1R58 A;  3CTZ A;  4FO8 A;  4PNC A;  3TAV A;  2HOW A;  4S2R P;  2ZSG A;  4IKS A;  4U73 A;  4FLI A;  3PKD A;  5JHU A;  2V6C A;  2BWU A;  4IF7 A;  2GG5 A;  2BB7 A;  2BH3 A;  5CIK A;  5D6F A;  1MAT A;  2ADU A;  4U69 A;  3IU7 A;  2P99 A;  4IU6 A;  2BHC A;  1M35 A;  4QR8 A;  4FLK A;  5E5B A;  1YJ3 A;  4RGZ 1;  4IKU A;  2BWV A;  3PN9 A;  4ZWP A;  4JUQ A;  2DFI A;  4IDY A;  3Q6D A;  4S2T P;  3IU8 A;  1N51 A;  2Q92 A;  1WBQ A;  3OVK A;  1BN5 A;  1QXY A;  4KM3 A;  4U6C A;  4U70 A;  2BWY A;  4FO7 A;  5CDV A;  2GTX A;  4B28 A;  3O5V A;  3RVA A;  5JFR A;  1C21 A;  4ZNG A;  4IEC A;  3PKC A;  1Y1N A;  2Q8K A;  4PV4 A;  1CHM A;  5JI6 A;  2GG2 A;  4IPA A;  3D27 A;  3IL0 A;  2BHD A;  1B59 A;  1R5H A;  3QOC A;  3IU9 A;  3I7M A;  2B3K A;  1WLR A;  3FM3 A;  2NQ7 A;  1WN1 A;  4ZWU A;  1YW7 A;  1XGO A;  4IKR A;  2GA2 A;  1XNZ A;  1B6A A;  1KP0 A;  2IW2 A;  1O0X A;  2EVM A;  2GU6 A;  1KQ9 A;  4A6V A;  1YVM A;  4FLL A;  3PKB A;  4U75 A;  5CDE A;  1QZY A;  5CDL A;  1WL6 A;  1XGN A;  1A16 A;  2G6P A;  1XGM A;  1PV9 A;  5FCH A;  4U6Z A;  5D6E A;  3MR1 A;  3ROR A;  2GU5 A;  1C22 A;  3BIP A;  2NQ6 A;  1WL9 A;  2B3H A;  3FMR A;  2EA2 A;  5CLS A;  4RZY A;  2GG7 A;  3MAT A;  2V3Z A;  3IG4 A;  4U6E A;  4R60 A;  4OOK A;  3BIT A;  4A6W A;  2BWW A;  2BWX A;  2Q95 A;  1JAW A;  2V3X A;  3PKA A;  1KQ0 A;  4FKC A;  5CNX A;  2V3Y A;  2GG9 A;  1YW9 A;  3CB5 A;  2GGC A;  1W2M A;  4U6W A;  1QXW A; 
#chains in the Genus database with same CATH topology
 2B3L A;  2EVO A;  2GU7 A;  3PKE A;  4S00 A;  4U1B A;  4ZWO A;  3L7G A;  2BHA A;  2BN7 A;  1W7V A;  3FMQ A;  2P98 A;  3L24 A;  4HXX A;  4U6J A;  1BOA A;  4U76 A;  2EA4 A;  2GGB A;  2BWT A;  2BWS A;  5E2C A;  4FUK A;  1YW8 A;  1WY2 A;  2OKN A;  1C23 A;  2GG0 A;  3MX6 A;  2Q94 A;  4Z7M A;  2GG8 A;  3PEB A;  1C27 A;  4RZZ A;  4MAT A;  1WKM A;  5CE6 A;  1C24 A;  1QXZ A;  2OAZ A;  2Q93 A;  3OOO A;  1XGS A;  2MAT A;  4FLJ A;  4EGE A;  2EVC A;  2GG3 A;  4IKT A;  4U71 A;  2GU4 A;  3TB5 A;  2P9A A;  5FCF A;  1R5G A;  2Q96 A;  3CB6 A;  2GZ5 A;  3S6B A;  2BHB A;  4S01 A;  3BIQ A;  1R58 A;  3CTZ A;  4FO8 A;  4PNC A;  3TAV A;  2HOW A;  4S2R P;  2ZSG A;  4IKS A;  4U73 A;  4FLI A;  3PKD A;  5JHU A;  2V6C A;  2BWU A;  4IF7 A;  2GG5 A;  2BB7 A;  2BH3 A;  5CIK A;  5D6F A;  1MAT A;  2ADU A;  4U69 A;  3IU7 A;  2P99 A;  4IU6 A;  2BHC A;  1M35 A;  4QR8 A;  4FLK A;  5E5B A;  1YJ3 A;  4RGZ 1;  4IKU A;  2BWV A;  3PN9 A;  4ZWP A;  4JUQ A;  2DFI A;  4IDY A;  3Q6D A;  4S2T P;  3IU8 A;  1N51 A;  2Q92 A;  1WBQ A;  3OVK A;  1BN5 A;  1QXY A;  4KM3 A;  4U6C A;  4U70 A;  2BWY A;  4FO7 A;  5CDV A;  2GTX A;  4B28 A;  3O5V A;  3RVA A;  5JFR A;  1C21 A;  4ZNG A;  4IEC A;  3PKC A;  1Y1N A;  2Q8K A;  4PV4 A;  1CHM A;  5JI6 A;  2GG2 A;  4IPA A;  3D27 A;  3IL0 A;  2BHD A;  1B59 A;  1R5H A;  3QOC A;  3IU9 A;  3I7M A;  2B3K A;  1WLR A;  3FM3 A;  2NQ7 A;  1WN1 A;  4ZWU A;  1YW7 A;  1XGO A;  4IKR A;  2GA2 A;  1XNZ A;  1B6A A;  1KP0 A;  2IW2 A;  1O0X A;  2EVM A;  2GU6 A;  1KQ9 A;  4A6V A;  1YVM A;  4FLL A;  3PKB A;  4U75 A;  5CDE A;  1QZY A;  5CDL A;  1WL6 A;  1XGN A;  1A16 A;  2G6P A;  1XGM A;  1PV9 A;  5FCH A;  4U6Z A;  5D6E A;  3MR1 A;  3ROR A;  2GU5 A;  1C22 A;  3BIP A;  2NQ6 A;  1WL9 A;  2B3H A;  3FMR A;  2EA2 A;  5CLS A;  4RZY A;  2GG7 A;  3MAT A;  2V3Z A;  3IG4 A;  4U6E A;  4R60 A;  4OOK A;  3BIT A;  4A6W A;  2BWW A;  2BWX A;  2Q95 A;  1JAW A;  2V3X A;  3PKA A;  1KQ0 A;  4FKC A;  5CNX A;  2V3Y A;  2GG9 A;  1YW9 A;  3CB5 A;  2GGC A;  1W2M A;  4U6W A;  1QXW A; 
#chains in the Genus database with same CATH homology
 2B3L A;  2EVO A;  2GU7 A;  3PKE A;  4S00 A;  4U1B A;  4ZWO A;  3L7G A;  2BHA A;  2BN7 A;  1W7V A;  3FMQ A;  2P98 A;  3L24 A;  4HXX A;  4U6J A;  1BOA A;  4U76 A;  2EA4 A;  2GGB A;  2BWT A;  2BWS A;  5E2C A;  4FUK A;  1YW8 A;  1WY2 A;  2OKN A;  1C23 A;  2GG0 A;  3MX6 A;  2Q94 A;  4Z7M A;  2GG8 A;  3PEB A;  1C27 A;  4RZZ A;  4MAT A;  1WKM A;  5CE6 A;  1C24 A;  1QXZ A;  2OAZ A;  2Q93 A;  3OOO A;  1XGS A;  2MAT A;  4FLJ A;  4EGE A;  2EVC A;  2GG3 A;  4IKT A;  4U71 A;  2GU4 A;  3TB5 A;  2P9A A;  5FCF A;  1R5G A;  2Q96 A;  3CB6 A;  2GZ5 A;  3S6B A;  2BHB A;  4S01 A;  3BIQ A;  1R58 A;  3CTZ A;  4FO8 A;  4PNC A;  3TAV A;  2HOW A;  4S2R P;  2ZSG A;  4IKS A;  4U73 A;  4FLI A;  3PKD A;  5JHU A;  2V6C A;  2BWU A;  4IF7 A;  2GG5 A;  2BB7 A;  2BH3 A;  5CIK A;  5D6F A;  1MAT A;  2ADU A;  4U69 A;  3IU7 A;  2P99 A;  4IU6 A;  2BHC A;  1M35 A;  4QR8 A;  4FLK A;  5E5B A;  1YJ3 A;  4RGZ 1;  4IKU A;  2BWV A;  3PN9 A;  4ZWP A;  4JUQ A;  2DFI A;  4IDY A;  3Q6D A;  4S2T P;  3IU8 A;  1N51 A;  2Q92 A;  1WBQ A;  3OVK A;  1BN5 A;  1QXY A;  4KM3 A;  4U6C A;  4U70 A;  2BWY A;  4FO7 A;  5CDV A;  2GTX A;  4B28 A;  3O5V A;  3RVA A;  5JFR A;  1C21 A;  4ZNG A;  4IEC A;  3PKC A;  1Y1N A;  2Q8K A;  4PV4 A;  1CHM A;  5JI6 A;  2GG2 A;  4IPA A;  3D27 A;  3IL0 A;  2BHD A;  1B59 A;  1R5H A;  3QOC A;  3IU9 A;  3I7M A;  2B3K A;  1WLR A;  3FM3 A;  2NQ7 A;  1WN1 A;  4ZWU A;  1YW7 A;  1XGO A;  4IKR A;  2GA2 A;  1XNZ A;  1B6A A;  1KP0 A;  2IW2 A;  1O0X A;  2EVM A;  2GU6 A;  1KQ9 A;  4A6V A;  1YVM A;  4FLL A;  3PKB A;  4U75 A;  5CDE A;  1QZY A;  5CDL A;  1WL6 A;  1XGN A;  1A16 A;  2G6P A;  1XGM A;  1PV9 A;  5FCH A;  4U6Z A;  5D6E A;  3MR1 A;  3ROR A;  2GU5 A;  1C22 A;  3BIP A;  2NQ6 A;  1WL9 A;  2B3H A;  3FMR A;  2EA2 A;  5CLS A;  4RZY A;  2GG7 A;  3MAT A;  2V3Z A;  3IG4 A;  4U6E A;  4R60 A;  4OOK A;  3BIT A;  4A6W A;  2BWW A;  2BWX A;  2Q95 A;  1JAW A;  2V3X A;  3PKA A;  1KQ0 A;  4FKC A;  5CNX A;  2V3Y A;  2GG9 A;  1YW9 A;  3CB5 A;  2GGC A;  1W2M A;  4U6W A;  1QXW A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...