4ZWOA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
sequence length
439
structure length
425
Chain Sequence
b'NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords organophosphate anhydrolase/prolidase
molecule tags Hydrolase
source organism Alteromonas sp.
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
total genus 158
structure length 425
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwoA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwoA02
4U6EA 4RGZ1 2BWWA 1A16A 3L7GA 3PKAA 4IKTA 5CIKA 3RVAA 5CE6A 3BITA 3I7MA 2GZ5A 2V3ZA 5E2CA 1QXWA 3OOOA 1WN1A 2ZSGA 2EVMA 2GG9A 3TAVA 3PKCA 2Q92A 5E5BA 4QR8A 2BH3A 4EGEA 3FMRA 2B3LA 2GU5A 3PKDA 2EVOA 1B6AA 2GG3A 2GU7A 1MATA 2Q96A 4ZNGA 1N51A 1PV9A 3CB6A 1R5HA 2BHAA 2P98A 4HXXA 4IKRA 3IL0A 2GGBA 4OOKA 3MATA 1WKMA 2NQ7A 4ZWUA 5CDVA 3L24A 3PKEA 1XGOA 2BWSA 3RORA 3S6BA 5JI6A 2BWVA 3IU9A 4U75A 3FMQA 5FCFA 2B3KA 2OKNA 1YW8A 4U76A 1B59A 1QXZA 2GG2A 2ADUA 1W2MA 2HOWA 4S2RP 2GU4A 5JFRA 2BHDA 2P9AA 2OAZA 3FM3A 2DFIA 2BWTA 1C24A 1YJ3A 4MATA 4A6VA 3MR1A 3QOCA 1XGSA 3BIPA 5CDLA 1WBQA 3PN9A 4RZZA 1KP0A 3Q6DA 4FKCA 1WL9A 2GA2A 4U6WA 2BB7A 3O5VA 4FO8A 2BHCA 1JAWA 4FUKA 4IPAA 2GGCA 3CB5A 5CLSA 2BN7A 4FLKA 1XGMA 1YVMA 3IU7A 4U6ZA 3CTZA 5CDEA 1R58A 2EVCA 4U69A 3BIQA 4B28A 2B3HA 3MX6A 4S2TP 4PNCA 4IDYA 2EA4A 4FO7A 3PKBA 3PEBA 4U70A 1C23A 4ZWOA 5D6FA 2GG5A 1BOAA 1C27A 1KQ9A 4IKSA 4KM3A 1C22A 2BHBA 3OVKA 4U6JA 3TB5A 2Q93A 4U6CA 4U71A 4R60A 4U1BA 5D6EA 4IF7A 2P99A 4FLJA 4IU6A 4ZWPA 1YW9A 4PV4A 3IU8A 2BWXA 2EA2A 1BN5A 1YW7A 1W7VA 2GG0A 4Z7MA 4U73A 2Q95A 2BWUA 2MATA 4S00A 5FCHA 2V3XA 1O0XA 1XNZA 1WL6A 2NQ6A 4FLLA 1XGNA 4IECA 1QZYA 2Q94A 5CNXA 4JUQA 1C21A 2GU6A 2V3YA 1R5GA 3D27A 4A6WA 1WLRA 2V6CA 4IKUA 2GTXA 1QXYA 2Q8KA 1M35A 3IG4A 2IW2A 2GG7A 4FLIA 2BWYA 1KQ0A 5JHUA 1CHMA 2G6PA 2GG8A 1Y1NA 1WY2A 4RZYA 4S01A
chains in the Genus database with same CATH superfamily
4U6EA 4RGZ1 2BWWA 1A16A 3L7GA 3PKAA 4IKTA 5CIKA 3RVAA 5CE6A 3BITA 3I7MA 2GZ5A 2V3ZA 5E2CA 1QXWA 3OOOA 1WN1A 2ZSGA 2EVMA 2GG9A 3TAVA 3PKCA 2Q92A 5E5BA 4QR8A 2BH3A 4EGEA 3FMRA 2B3LA 2GU5A 3PKDA 2EVOA 1B6AA 2GG3A 2GU7A 1MATA 2Q96A 4ZNGA 1N51A 1PV9A 3CB6A 1R5HA 2BHAA 2P98A 4HXXA 4IKRA 3IL0A 2GGBA 4OOKA 3MATA 1WKMA 2NQ7A 4ZWUA 5CDVA 3L24A 3PKEA 1XGOA 2BWSA 3RORA 3S6BA 5JI6A 2BWVA 3IU9A 4U75A 3FMQA 5FCFA 2B3KA 2OKNA 1YW8A 4U76A 1B59A 1QXZA 2GG2A 2ADUA 1W2MA 2HOWA 4S2RP 2GU4A 5JFRA 2BHDA 2P9AA 2OAZA 3FM3A 2DFIA 2BWTA 1C24A 1YJ3A 4MATA 4A6VA 3MR1A 3QOCA 1XGSA 3BIPA 5CDLA 1WBQA 3PN9A 4RZZA 1KP0A 3Q6DA 4FKCA 1WL9A 2GA2A 4U6WA 2BB7A 3O5VA 4FO8A 2BHCA 1JAWA 4FUKA 4IPAA 2GGCA 3CB5A 5CLSA 2BN7A 4FLKA 1XGMA 1YVMA 3IU7A 4U6ZA 3CTZA 5CDEA 1R58A 2EVCA 4U69A 3BIQA 4B28A 2B3HA 3MX6A 4S2TP 4PNCA 4IDYA 2EA4A 4FO7A 3PKBA 3PEBA 4U70A 1C23A 4ZWOA 5D6FA 2GG5A 1BOAA 1C27A 1KQ9A 4IKSA 4KM3A 1C22A 2BHBA 3OVKA 4U6JA 3TB5A 2Q93A 4U6CA 4U71A 4R60A 4U1BA 5D6EA 4IF7A 2P99A 4FLJA 4IU6A 4ZWPA 1YW9A 4PV4A 3IU8A 2BWXA 2EA2A 1BN5A 1YW7A 1W7VA 2GG0A 4Z7MA 4U73A 2Q95A 2BWUA 2MATA 4S00A 5FCHA 2V3XA 1O0XA 1XNZA 1WL6A 2NQ6A 4FLLA 1XGNA 4IECA 1QZYA 2Q94A 5CNXA 4JUQA 1C21A 2GU6A 2V3YA 1R5GA 3D27A 4A6WA 1WLRA 2V6CA 4IKUA 2GTXA 1QXYA 2Q8KA 1M35A 3IG4A 2IW2A 2GG7A 4FLIA 2BWYA 1KQ0A 5JHUA 1CHMA 2G6PA 2GG8A 1Y1NA 1WY2A 4RZYA 4S01A
chains in the Genus database with same CATH topology
4U6EA 4RGZ1 2BWWA 1A16A 3L7GA 3PKAA 4IKTA 5CIKA 3RVAA 5CE6A 3BITA 3I7MA 2GZ5A 2V3ZA 5E2CA 1QXWA 3OOOA 1WN1A 2ZSGA 2EVMA 2GG9A 3TAVA 3PKCA 2Q92A 5E5BA 4QR8A 2BH3A 4EGEA 3FMRA 2B3LA 2GU5A 3PKDA 2EVOA 1B6AA 2GG3A 2GU7A 1MATA 2Q96A 4ZNGA 1N51A 1PV9A 3CB6A 1R5HA 2BHAA 2P98A 4HXXA 4IKRA 3IL0A 2GGBA 4OOKA 3MATA 1WKMA 2NQ7A 4ZWUA 5CDVA 3L24A 3PKEA 1XGOA 2BWSA 3RORA 3S6BA 5JI6A 2BWVA 3IU9A 4U75A 3FMQA 5FCFA 2B3KA 2OKNA 1YW8A 4U76A 1B59A 1QXZA 2GG2A 2ADUA 1W2MA 2HOWA 4S2RP 2GU4A 5JFRA 2BHDA 2P9AA 2OAZA 3FM3A 2DFIA 2BWTA 1C24A 1YJ3A 4MATA 4A6VA 3MR1A 3QOCA 1XGSA 3BIPA 5CDLA 1WBQA 3PN9A 4RZZA 1KP0A 3Q6DA 4FKCA 1WL9A 2GA2A 4U6WA 2BB7A 3O5VA 4FO8A 2BHCA 1JAWA 4FUKA 4IPAA 2GGCA 3CB5A 5CLSA 2BN7A 4FLKA 1XGMA 1YVMA 3IU7A 4U6ZA 3CTZA 5CDEA 1R58A 2EVCA 4U69A 3BIQA 4B28A 2B3HA 3MX6A 4S2TP 4PNCA 4IDYA 2EA4A 4FO7A 3PKBA 3PEBA 4U70A 1C23A 4ZWOA 5D6FA 2GG5A 1BOAA 1C27A 1KQ9A 4IKSA 4KM3A 1C22A 2BHBA 3OVKA 4U6JA 3TB5A 2Q93A 4U6CA 4U71A 4R60A 4U1BA 5D6EA 4IF7A 2P99A 4FLJA 4IU6A 4ZWPA 1YW9A 4PV4A 3IU8A 2BWXA 2EA2A 1BN5A 1YW7A 1W7VA 2GG0A 4Z7MA 4U73A 2Q95A 2BWUA 2MATA 4S00A 5FCHA 2V3XA 1O0XA 1XNZA 1WL6A 2NQ6A 4FLLA 1XGNA 4IECA 1QZYA 2Q94A 5CNXA 4JUQA 1C21A 2GU6A 2V3YA 1R5GA 3D27A 4A6WA 1WLRA 2V6CA 4IKUA 2GTXA 1QXYA 2Q8KA 1M35A 3IG4A 2IW2A 2GG7A 4FLIA 2BWYA 1KQ0A 5JHUA 1CHMA 2G6PA 2GG8A 1Y1NA 1WY2A 4RZYA 4S01A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U6E A;  4RGZ 1;  2BWW A;  1A16 A;  3L7G A;  3PKA A;  4IKT A;  5CIK A;  3RVA A;  5CE6 A;  3BIT A;  3I7M A;  2GZ5 A;  2V3Z A;  5E2C A;  1QXW A;  3OOO A;  1WN1 A;  2ZSG A;  2EVM A;  2GG9 A;  3TAV A;  3PKC A;  2Q92 A;  5E5B A;  4QR8 A;  2BH3 A;  4EGE A;  3FMR A;  2B3L A;  2GU5 A;  3PKD A;  2EVO A;  1B6A A;  2GG3 A;  2GU7 A;  1MAT A;  2Q96 A;  4ZNG A;  1N51 A;  1PV9 A;  3CB6 A;  1R5H A;  2BHA A;  2P98 A;  4HXX A;  4IKR A;  3IL0 A;  2GGB A;  4OOK A;  3MAT A;  1WKM A;  2NQ7 A;  4ZWU A;  5CDV A;  3L24 A;  3PKE A;  1XGO A;  2BWS A;  3ROR A;  3S6B A;  5JI6 A;  2BWV A;  3IU9 A;  4U75 A;  3FMQ A;  5FCF A;  2B3K A;  2OKN A;  1YW8 A;  4U76 A;  1B59 A;  1QXZ A;  2GG2 A;  2ADU A;  1W2M A;  2HOW A;  4S2R P;  2GU4 A;  5JFR A;  2BHD A;  2P9A A;  2OAZ A;  3FM3 A;  2DFI A;  2BWT A;  1C24 A;  1YJ3 A;  4MAT A;  4A6V A;  3MR1 A;  3QOC A;  1XGS A;  3BIP A;  5CDL A;  1WBQ A;  3PN9 A;  4RZZ A;  1KP0 A;  3Q6D A;  4FKC A;  1WL9 A;  2GA2 A;  4U6W A;  2BB7 A;  3O5V A;  4FO8 A;  2BHC A;  1JAW A;  4FUK A;  4IPA A;  2GGC A;  3CB5 A;  5CLS A;  2BN7 A;  4FLK A;  1XGM A;  1YVM A;  3IU7 A;  4U6Z A;  3CTZ A;  5CDE A;  1R58 A;  2EVC A;  4U69 A;  3BIQ A;  4B28 A;  2B3H A;  3MX6 A;  4S2T P;  4PNC A;  4IDY A;  2EA4 A;  4FO7 A;  3PKB A;  3PEB A;  4U70 A;  1C23 A;  4ZWO A;  5D6F A;  2GG5 A;  1BOA A;  1C27 A;  1KQ9 A;  4IKS A;  4KM3 A;  1C22 A;  2BHB A;  3OVK A;  4U6J A;  3TB5 A;  2Q93 A;  4U6C A;  4U71 A;  4R60 A;  4U1B A;  5D6E A;  4IF7 A;  2P99 A;  4FLJ A;  4IU6 A;  4ZWP A;  1YW9 A;  4PV4 A;  3IU8 A;  2BWX A;  2EA2 A;  1BN5 A;  1YW7 A;  1W7V A;  2GG0 A;  4Z7M A;  4U73 A;  2Q95 A;  2BWU A;  2MAT A;  4S00 A;  5FCH A;  2V3X A;  1O0X A;  1XNZ A;  1WL6 A;  2NQ6 A;  4FLL A;  1XGN A;  4IEC A;  1QZY A;  2Q94 A;  5CNX A;  4JUQ A;  1C21 A;  2GU6 A;  2V3Y A;  1R5G A;  3D27 A;  4A6W A;  1WLR A;  2V6C A;  4IKU A;  2GTX A;  1QXY A;  2Q8K A;  1M35 A;  3IG4 A;  2IW2 A;  2GG7 A;  4FLI A;  2BWY A;  1KQ0 A;  5JHU A;  1CHM A;  2G6P A;  2GG8 A;  1Y1N A;  1WY2 A;  4RZY A;  4S01 A; 
#chains in the Genus database with same CATH topology
 4U6E A;  4RGZ 1;  2BWW A;  1A16 A;  3L7G A;  3PKA A;  4IKT A;  5CIK A;  3RVA A;  5CE6 A;  3BIT A;  3I7M A;  2GZ5 A;  2V3Z A;  5E2C A;  1QXW A;  3OOO A;  1WN1 A;  2ZSG A;  2EVM A;  2GG9 A;  3TAV A;  3PKC A;  2Q92 A;  5E5B A;  4QR8 A;  2BH3 A;  4EGE A;  3FMR A;  2B3L A;  2GU5 A;  3PKD A;  2EVO A;  1B6A A;  2GG3 A;  2GU7 A;  1MAT A;  2Q96 A;  4ZNG A;  1N51 A;  1PV9 A;  3CB6 A;  1R5H A;  2BHA A;  2P98 A;  4HXX A;  4IKR A;  3IL0 A;  2GGB A;  4OOK A;  3MAT A;  1WKM A;  2NQ7 A;  4ZWU A;  5CDV A;  3L24 A;  3PKE A;  1XGO A;  2BWS A;  3ROR A;  3S6B A;  5JI6 A;  2BWV A;  3IU9 A;  4U75 A;  3FMQ A;  5FCF A;  2B3K A;  2OKN A;  1YW8 A;  4U76 A;  1B59 A;  1QXZ A;  2GG2 A;  2ADU A;  1W2M A;  2HOW A;  4S2R P;  2GU4 A;  5JFR A;  2BHD A;  2P9A A;  2OAZ A;  3FM3 A;  2DFI A;  2BWT A;  1C24 A;  1YJ3 A;  4MAT A;  4A6V A;  3MR1 A;  3QOC A;  1XGS A;  3BIP A;  5CDL A;  1WBQ A;  3PN9 A;  4RZZ A;  1KP0 A;  3Q6D A;  4FKC A;  1WL9 A;  2GA2 A;  4U6W A;  2BB7 A;  3O5V A;  4FO8 A;  2BHC A;  1JAW A;  4FUK A;  4IPA A;  2GGC A;  3CB5 A;  5CLS A;  2BN7 A;  4FLK A;  1XGM A;  1YVM A;  3IU7 A;  4U6Z A;  3CTZ A;  5CDE A;  1R58 A;  2EVC A;  4U69 A;  3BIQ A;  4B28 A;  2B3H A;  3MX6 A;  4S2T P;  4PNC A;  4IDY A;  2EA4 A;  4FO7 A;  3PKB A;  3PEB A;  4U70 A;  1C23 A;  4ZWO A;  5D6F A;  2GG5 A;  1BOA A;  1C27 A;  1KQ9 A;  4IKS A;  4KM3 A;  1C22 A;  2BHB A;  3OVK A;  4U6J A;  3TB5 A;  2Q93 A;  4U6C A;  4U71 A;  4R60 A;  4U1B A;  5D6E A;  4IF7 A;  2P99 A;  4FLJ A;  4IU6 A;  4ZWP A;  1YW9 A;  4PV4 A;  3IU8 A;  2BWX A;  2EA2 A;  1BN5 A;  1YW7 A;  1W7V A;  2GG0 A;  4Z7M A;  4U73 A;  2Q95 A;  2BWU A;  2MAT A;  4S00 A;  5FCH A;  2V3X A;  1O0X A;  1XNZ A;  1WL6 A;  2NQ6 A;  4FLL A;  1XGN A;  4IEC A;  1QZY A;  2Q94 A;  5CNX A;  4JUQ A;  1C21 A;  2GU6 A;  2V3Y A;  1R5G A;  3D27 A;  4A6W A;  1WLR A;  2V6C A;  4IKU A;  2GTX A;  1QXY A;  2Q8K A;  1M35 A;  3IG4 A;  2IW2 A;  2GG7 A;  4FLI A;  2BWY A;  1KQ0 A;  5JHU A;  1CHM A;  2G6P A;  2GG8 A;  1Y1N A;  1WY2 A;  4RZY A;  4S01 A; 
#chains in the Genus database with same CATH homology
 4U6E A;  4RGZ 1;  2BWW A;  1A16 A;  3L7G A;  3PKA A;  4IKT A;  5CIK A;  3RVA A;  5CE6 A;  3BIT A;  3I7M A;  2GZ5 A;  2V3Z A;  5E2C A;  1QXW A;  3OOO A;  1WN1 A;  2ZSG A;  2EVM A;  2GG9 A;  3TAV A;  3PKC A;  2Q92 A;  5E5B A;  4QR8 A;  2BH3 A;  4EGE A;  3FMR A;  2B3L A;  2GU5 A;  3PKD A;  2EVO A;  1B6A A;  2GG3 A;  2GU7 A;  1MAT A;  2Q96 A;  4ZNG A;  1N51 A;  1PV9 A;  3CB6 A;  1R5H A;  2BHA A;  2P98 A;  4HXX A;  4IKR A;  3IL0 A;  2GGB A;  4OOK A;  3MAT A;  1WKM A;  2NQ7 A;  4ZWU A;  5CDV A;  3L24 A;  3PKE A;  1XGO A;  2BWS A;  3ROR A;  3S6B A;  5JI6 A;  2BWV A;  3IU9 A;  4U75 A;  3FMQ A;  5FCF A;  2B3K A;  2OKN A;  1YW8 A;  4U76 A;  1B59 A;  1QXZ A;  2GG2 A;  2ADU A;  1W2M A;  2HOW A;  4S2R P;  2GU4 A;  5JFR A;  2BHD A;  2P9A A;  2OAZ A;  3FM3 A;  2DFI A;  2BWT A;  1C24 A;  1YJ3 A;  4MAT A;  4A6V A;  3MR1 A;  3QOC A;  1XGS A;  3BIP A;  5CDL A;  1WBQ A;  3PN9 A;  4RZZ A;  1KP0 A;  3Q6D A;  4FKC A;  1WL9 A;  2GA2 A;  4U6W A;  2BB7 A;  3O5V A;  4FO8 A;  2BHC A;  1JAW A;  4FUK A;  4IPA A;  2GGC A;  3CB5 A;  5CLS A;  2BN7 A;  4FLK A;  1XGM A;  1YVM A;  3IU7 A;  4U6Z A;  3CTZ A;  5CDE A;  1R58 A;  2EVC A;  4U69 A;  3BIQ A;  4B28 A;  2B3H A;  3MX6 A;  4S2T P;  4PNC A;  4IDY A;  2EA4 A;  4FO7 A;  3PKB A;  3PEB A;  4U70 A;  1C23 A;  4ZWO A;  5D6F A;  2GG5 A;  1BOA A;  1C27 A;  1KQ9 A;  4IKS A;  4KM3 A;  1C22 A;  2BHB A;  3OVK A;  4U6J A;  3TB5 A;  2Q93 A;  4U6C A;  4U71 A;  4R60 A;  4U1B A;  5D6E A;  4IF7 A;  2P99 A;  4FLJ A;  4IU6 A;  4ZWP A;  1YW9 A;  4PV4 A;  3IU8 A;  2BWX A;  2EA2 A;  1BN5 A;  1YW7 A;  1W7V A;  2GG0 A;  4Z7M A;  4U73 A;  2Q95 A;  2BWU A;  2MAT A;  4S00 A;  5FCH A;  2V3X A;  1O0X A;  1XNZ A;  1WL6 A;  2NQ6 A;  4FLL A;  1XGN A;  4IEC A;  1QZY A;  2Q94 A;  5CNX A;  4JUQ A;  1C21 A;  2GU6 A;  2V3Y A;  1R5G A;  3D27 A;  4A6W A;  1WLR A;  2V6C A;  4IKU A;  2GTX A;  1QXY A;  2Q8K A;  1M35 A;  3IG4 A;  2IW2 A;  2GG7 A;  4FLI A;  2BWY A;  1KQ0 A;  5JHU A;  1CHM A;  2G6P A;  2GG8 A;  1Y1N A;  1WY2 A;  4RZY A;  4S01 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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