4ZWOA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
sequence length
439
structure length
425
Chain Sequence
NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords organophosphate anhydrolase/prolidase
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
total genus 158
structure length 425
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwoA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwoA02
2G6PA 4IKRA 3PKBA 2BHBA 1CHMA 4ZWPA 3IU7A 1MATA 2BH3A 2BHCA 2BN7A 4ZWOA 1XGNA 4RZZA 2P98A 1XGOA 2V6CA 2NQ7A 5JI6A 3OOOA 1W2MA 1B59A 1BOAA 3CB5A 2GA2A 1R5HA 2NQ6A 5CDEA 4FLLA 1O0XA 3Q6DA 2BWVA 2GG2A 2P9AA 1C27A 2BHAA 1YVMA 1JAWA 4FUKA 4FKCA 2Q93A 3QOCA 1WBQA 1XGMA 5CDLA 5CE6A 2V3XA 4FLKA 3I7MA 3PEBA 3CB6A 3MX6A 4IECA 2B3HA 1Y1NA 3IU9A 3PKCA 3IU8A 2Q94A 5JFRA 2GG0A 5D6FA 3TAVA 1M35A 4U69A 2BHDA 2GGBA 1W7VA 2V3YA 2GU7A 1WLRA 4U6WA 2OAZA 2HOWA 2BWYA 4S2TP 4Z7MA 5CLSA 4S01A 2ADUA 3FM3A 1BN5A 3BITA 1C24A 2Q96A 2MATA 4U73A 3RVAA 2GGCA 4KM3A 4IDYA 5CDVA 2BB7A 1WKMA 1WN1A 3MR1A 4U6JA 4EGEA 4A6VA 1N51A 1B6AA 4FLIA 4U71A 3S6BA 5E2CA 2B3LA 1YW7A 2GU5A 1KQ0A 2GG9A 4U1BA 5JHUA 4R60A 1YJ3A 1A16A 2P99A 4ZNGA 5D6EA 3IL0A 4IKSA 4U6ZA 3PKAA 4QR8A 4FLJA 2IW2A 1YW9A 4JUQA 3PN9A 2ZSGA 3FMRA 4S00A 1QXWA 2EA4A 3RORA 4U6EA 2GG3A 2EVOA 2DFIA 4PV4A 3PKEA 1QXYA 4A6WA 2OKNA 3BIPA 1KQ9A 1XNZA 3TB5A 2V3ZA 5CNXA 2GG8A 2Q95A 2B3KA 5CIKA 3OVKA 4FO7A 4U6CA 4U70A 3CTZA 1YW8A 1QXZA 1WL6A 4S2RP 2GG5A 5E5BA 4ZWUA 2EA2A 2GG7A 3MATA 1XGSA 4IU6A 3BIQA 2EVMA 1C21A 3FMQA 3L7GA 2BWXA 1KP0A 4IPAA 1QZYA 2EVCA 2BWUA 1WY2A 4MATA 3D27A 3L24A 2GU6A 2GTXA 4U75A 4IF7A 2Q92A 2BWSA 4OOKA 2GU4A 4HXXA 2BWTA 4IKUA 4RZYA 4PNCA 5FCFA 2Q8KA 1WL9A 3O5VA 1C23A 1R5GA 3IG4A 1PV9A 5FCHA 4B28A 4FO8A 2GZ5A 1C22A 1R58A 4IKTA 3PKDA 4RGZ1 4U76A 2BWWA
chains in the Genus database with same CATH superfamily
2G6PA 4IKRA 3PKBA 2BHBA 1CHMA 4ZWPA 3IU7A 1MATA 2BH3A 2BHCA 2BN7A 4ZWOA 1XGNA 4RZZA 2P98A 1XGOA 2V6CA 2NQ7A 5JI6A 3OOOA 1W2MA 1B59A 1BOAA 3CB5A 2GA2A 1R5HA 2NQ6A 5CDEA 4FLLA 1O0XA 3Q6DA 2BWVA 2GG2A 2P9AA 1C27A 2BHAA 1YVMA 1JAWA 4FUKA 4FKCA 2Q93A 3QOCA 1WBQA 1XGMA 5CDLA 5CE6A 2V3XA 4FLKA 3I7MA 3PEBA 3CB6A 3MX6A 4IECA 2B3HA 1Y1NA 3IU9A 3PKCA 3IU8A 2Q94A 5JFRA 2GG0A 5D6FA 3TAVA 1M35A 4U69A 2BHDA 2GGBA 1W7VA 2V3YA 2GU7A 1WLRA 4U6WA 2OAZA 2HOWA 2BWYA 4S2TP 4Z7MA 5CLSA 4S01A 2ADUA 3FM3A 1BN5A 3BITA 1C24A 2Q96A 2MATA 4U73A 3RVAA 2GGCA 4KM3A 4IDYA 5CDVA 2BB7A 1WKMA 1WN1A 3MR1A 4U6JA 4EGEA 4A6VA 1N51A 1B6AA 4FLIA 4U71A 3S6BA 5E2CA 2B3LA 1YW7A 2GU5A 1KQ0A 2GG9A 4U1BA 5JHUA 4R60A 1YJ3A 1A16A 2P99A 4ZNGA 5D6EA 3IL0A 4IKSA 4U6ZA 3PKAA 4QR8A 4FLJA 2IW2A 1YW9A 4JUQA 3PN9A 2ZSGA 3FMRA 4S00A 1QXWA 2EA4A 3RORA 4U6EA 2GG3A 2EVOA 2DFIA 4PV4A 3PKEA 1QXYA 4A6WA 2OKNA 3BIPA 1KQ9A 1XNZA 3TB5A 2V3ZA 5CNXA 2GG8A 2Q95A 2B3KA 5CIKA 3OVKA 4FO7A 4U6CA 4U70A 3CTZA 1YW8A 1QXZA 1WL6A 4S2RP 2GG5A 5E5BA 4ZWUA 2EA2A 2GG7A 3MATA 1XGSA 4IU6A 3BIQA 2EVMA 1C21A 3FMQA 3L7GA 2BWXA 1KP0A 4IPAA 1QZYA 2EVCA 2BWUA 1WY2A 4MATA 3D27A 3L24A 2GU6A 2GTXA 4U75A 4IF7A 2Q92A 2BWSA 4OOKA 2GU4A 4HXXA 2BWTA 4IKUA 4RZYA 4PNCA 5FCFA 2Q8KA 1WL9A 3O5VA 1C23A 1R5GA 3IG4A 1PV9A 5FCHA 4B28A 4FO8A 2GZ5A 1C22A 1R58A 4IKTA 3PKDA 4RGZ1 4U76A 2BWWA
chains in the Genus database with same CATH topology
2G6PA 4IKRA 3PKBA 2BHBA 1CHMA 4ZWPA 3IU7A 1MATA 2BH3A 2BHCA 2BN7A 4ZWOA 1XGNA 4RZZA 2P98A 1XGOA 2V6CA 2NQ7A 5JI6A 3OOOA 1W2MA 1B59A 1BOAA 3CB5A 2GA2A 1R5HA 2NQ6A 5CDEA 4FLLA 1O0XA 3Q6DA 2BWVA 2GG2A 2P9AA 1C27A 2BHAA 1YVMA 1JAWA 4FUKA 4FKCA 2Q93A 3QOCA 1WBQA 1XGMA 5CDLA 5CE6A 2V3XA 4FLKA 3I7MA 3PEBA 3CB6A 3MX6A 4IECA 2B3HA 1Y1NA 3IU9A 3PKCA 3IU8A 2Q94A 5JFRA 2GG0A 5D6FA 3TAVA 1M35A 4U69A 2BHDA 2GGBA 1W7VA 2V3YA 2GU7A 1WLRA 4U6WA 2OAZA 2HOWA 2BWYA 4S2TP 4Z7MA 5CLSA 4S01A 2ADUA 3FM3A 1BN5A 3BITA 1C24A 2Q96A 2MATA 4U73A 3RVAA 2GGCA 4KM3A 4IDYA 5CDVA 2BB7A 1WKMA 1WN1A 3MR1A 4U6JA 4EGEA 4A6VA 1N51A 1B6AA 4FLIA 4U71A 3S6BA 5E2CA 2B3LA 1YW7A 2GU5A 1KQ0A 2GG9A 4U1BA 5JHUA 4R60A 1YJ3A 1A16A 2P99A 4ZNGA 5D6EA 3IL0A 4IKSA 4U6ZA 3PKAA 4QR8A 4FLJA 2IW2A 1YW9A 4JUQA 3PN9A 2ZSGA 3FMRA 4S00A 1QXWA 2EA4A 3RORA 4U6EA 2GG3A 2EVOA 2DFIA 4PV4A 3PKEA 1QXYA 4A6WA 2OKNA 3BIPA 1KQ9A 1XNZA 3TB5A 2V3ZA 5CNXA 2GG8A 2Q95A 2B3KA 5CIKA 3OVKA 4FO7A 4U6CA 4U70A 3CTZA 1YW8A 1QXZA 1WL6A 4S2RP 2GG5A 5E5BA 4ZWUA 2EA2A 2GG7A 3MATA 1XGSA 4IU6A 3BIQA 2EVMA 1C21A 3FMQA 3L7GA 2BWXA 1KP0A 4IPAA 1QZYA 2EVCA 2BWUA 1WY2A 4MATA 3D27A 3L24A 2GU6A 2GTXA 4U75A 4IF7A 2Q92A 2BWSA 4OOKA 2GU4A 4HXXA 2BWTA 4IKUA 4RZYA 4PNCA 5FCFA 2Q8KA 1WL9A 3O5VA 1C23A 1R5GA 3IG4A 1PV9A 5FCHA 4B28A 4FO8A 2GZ5A 1C22A 1R58A 4IKTA 3PKDA 4RGZ1 4U76A 2BWWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2G6P A;  4IKR A;  3PKB A;  2BHB A;  1CHM A;  4ZWP A;  3IU7 A;  1MAT A;  2BH3 A;  2BHC A;  2BN7 A;  4ZWO A;  1XGN A;  4RZZ A;  2P98 A;  1XGO A;  2V6C A;  2NQ7 A;  5JI6 A;  3OOO A;  1W2M A;  1B59 A;  1BOA A;  3CB5 A;  2GA2 A;  1R5H A;  2NQ6 A;  5CDE A;  4FLL A;  1O0X A;  3Q6D A;  2BWV A;  2GG2 A;  2P9A A;  1C27 A;  2BHA A;  1YVM A;  1JAW A;  4FUK A;  4FKC A;  2Q93 A;  3QOC A;  1WBQ A;  1XGM A;  5CDL A;  5CE6 A;  2V3X A;  4FLK A;  3I7M A;  3PEB A;  3CB6 A;  3MX6 A;  4IEC A;  2B3H A;  1Y1N A;  3IU9 A;  3PKC A;  3IU8 A;  2Q94 A;  5JFR A;  2GG0 A;  5D6F A;  3TAV A;  1M35 A;  4U69 A;  2BHD A;  2GGB A;  1W7V A;  2V3Y A;  2GU7 A;  1WLR A;  4U6W A;  2OAZ A;  2HOW A;  2BWY A;  4S2T P;  4Z7M A;  5CLS A;  4S01 A;  2ADU A;  3FM3 A;  1BN5 A;  3BIT A;  1C24 A;  2Q96 A;  2MAT A;  4U73 A;  3RVA A;  2GGC A;  4KM3 A;  4IDY A;  5CDV A;  2BB7 A;  1WKM A;  1WN1 A;  3MR1 A;  4U6J A;  4EGE A;  4A6V A;  1N51 A;  1B6A A;  4FLI A;  4U71 A;  3S6B A;  5E2C A;  2B3L A;  1YW7 A;  2GU5 A;  1KQ0 A;  2GG9 A;  4U1B A;  5JHU A;  4R60 A;  1YJ3 A;  1A16 A;  2P99 A;  4ZNG A;  5D6E A;  3IL0 A;  4IKS A;  4U6Z A;  3PKA A;  4QR8 A;  4FLJ A;  2IW2 A;  1YW9 A;  4JUQ A;  3PN9 A;  2ZSG A;  3FMR A;  4S00 A;  1QXW A;  2EA4 A;  3ROR A;  4U6E A;  2GG3 A;  2EVO A;  2DFI A;  4PV4 A;  3PKE A;  1QXY A;  4A6W A;  2OKN A;  3BIP A;  1KQ9 A;  1XNZ A;  3TB5 A;  2V3Z A;  5CNX A;  2GG8 A;  2Q95 A;  2B3K A;  5CIK A;  3OVK A;  4FO7 A;  4U6C A;  4U70 A;  3CTZ A;  1YW8 A;  1QXZ A;  1WL6 A;  4S2R P;  2GG5 A;  5E5B A;  4ZWU A;  2EA2 A;  2GG7 A;  3MAT A;  1XGS A;  4IU6 A;  3BIQ A;  2EVM A;  1C21 A;  3FMQ A;  3L7G A;  2BWX A;  1KP0 A;  4IPA A;  1QZY A;  2EVC A;  2BWU A;  1WY2 A;  4MAT A;  3D27 A;  3L24 A;  2GU6 A;  2GTX A;  4U75 A;  4IF7 A;  2Q92 A;  2BWS A;  4OOK A;  2GU4 A;  4HXX A;  2BWT A;  4IKU A;  4RZY A;  4PNC A;  5FCF A;  2Q8K A;  1WL9 A;  3O5V A;  1C23 A;  1R5G A;  3IG4 A;  1PV9 A;  5FCH A;  4B28 A;  4FO8 A;  2GZ5 A;  1C22 A;  1R58 A;  4IKT A;  3PKD A;  4RGZ 1;  4U76 A;  2BWW A; 
#chains in the Genus database with same CATH topology
 2G6P A;  4IKR A;  3PKB A;  2BHB A;  1CHM A;  4ZWP A;  3IU7 A;  1MAT A;  2BH3 A;  2BHC A;  2BN7 A;  4ZWO A;  1XGN A;  4RZZ A;  2P98 A;  1XGO A;  2V6C A;  2NQ7 A;  5JI6 A;  3OOO A;  1W2M A;  1B59 A;  1BOA A;  3CB5 A;  2GA2 A;  1R5H A;  2NQ6 A;  5CDE A;  4FLL A;  1O0X A;  3Q6D A;  2BWV A;  2GG2 A;  2P9A A;  1C27 A;  2BHA A;  1YVM A;  1JAW A;  4FUK A;  4FKC A;  2Q93 A;  3QOC A;  1WBQ A;  1XGM A;  5CDL A;  5CE6 A;  2V3X A;  4FLK A;  3I7M A;  3PEB A;  3CB6 A;  3MX6 A;  4IEC A;  2B3H A;  1Y1N A;  3IU9 A;  3PKC A;  3IU8 A;  2Q94 A;  5JFR A;  2GG0 A;  5D6F A;  3TAV A;  1M35 A;  4U69 A;  2BHD A;  2GGB A;  1W7V A;  2V3Y A;  2GU7 A;  1WLR A;  4U6W A;  2OAZ A;  2HOW A;  2BWY A;  4S2T P;  4Z7M A;  5CLS A;  4S01 A;  2ADU A;  3FM3 A;  1BN5 A;  3BIT A;  1C24 A;  2Q96 A;  2MAT A;  4U73 A;  3RVA A;  2GGC A;  4KM3 A;  4IDY A;  5CDV A;  2BB7 A;  1WKM A;  1WN1 A;  3MR1 A;  4U6J A;  4EGE A;  4A6V A;  1N51 A;  1B6A A;  4FLI A;  4U71 A;  3S6B A;  5E2C A;  2B3L A;  1YW7 A;  2GU5 A;  1KQ0 A;  2GG9 A;  4U1B A;  5JHU A;  4R60 A;  1YJ3 A;  1A16 A;  2P99 A;  4ZNG A;  5D6E A;  3IL0 A;  4IKS A;  4U6Z A;  3PKA A;  4QR8 A;  4FLJ A;  2IW2 A;  1YW9 A;  4JUQ A;  3PN9 A;  2ZSG A;  3FMR A;  4S00 A;  1QXW A;  2EA4 A;  3ROR A;  4U6E A;  2GG3 A;  2EVO A;  2DFI A;  4PV4 A;  3PKE A;  1QXY A;  4A6W A;  2OKN A;  3BIP A;  1KQ9 A;  1XNZ A;  3TB5 A;  2V3Z A;  5CNX A;  2GG8 A;  2Q95 A;  2B3K A;  5CIK A;  3OVK A;  4FO7 A;  4U6C A;  4U70 A;  3CTZ A;  1YW8 A;  1QXZ A;  1WL6 A;  4S2R P;  2GG5 A;  5E5B A;  4ZWU A;  2EA2 A;  2GG7 A;  3MAT A;  1XGS A;  4IU6 A;  3BIQ A;  2EVM A;  1C21 A;  3FMQ A;  3L7G A;  2BWX A;  1KP0 A;  4IPA A;  1QZY A;  2EVC A;  2BWU A;  1WY2 A;  4MAT A;  3D27 A;  3L24 A;  2GU6 A;  2GTX A;  4U75 A;  4IF7 A;  2Q92 A;  2BWS A;  4OOK A;  2GU4 A;  4HXX A;  2BWT A;  4IKU A;  4RZY A;  4PNC A;  5FCF A;  2Q8K A;  1WL9 A;  3O5V A;  1C23 A;  1R5G A;  3IG4 A;  1PV9 A;  5FCH A;  4B28 A;  4FO8 A;  2GZ5 A;  1C22 A;  1R58 A;  4IKT A;  3PKD A;  4RGZ 1;  4U76 A;  2BWW A; 
#chains in the Genus database with same CATH homology
 2G6P A;  4IKR A;  3PKB A;  2BHB A;  1CHM A;  4ZWP A;  3IU7 A;  1MAT A;  2BH3 A;  2BHC A;  2BN7 A;  4ZWO A;  1XGN A;  4RZZ A;  2P98 A;  1XGO A;  2V6C A;  2NQ7 A;  5JI6 A;  3OOO A;  1W2M A;  1B59 A;  1BOA A;  3CB5 A;  2GA2 A;  1R5H A;  2NQ6 A;  5CDE A;  4FLL A;  1O0X A;  3Q6D A;  2BWV A;  2GG2 A;  2P9A A;  1C27 A;  2BHA A;  1YVM A;  1JAW A;  4FUK A;  4FKC A;  2Q93 A;  3QOC A;  1WBQ A;  1XGM A;  5CDL A;  5CE6 A;  2V3X A;  4FLK A;  3I7M A;  3PEB A;  3CB6 A;  3MX6 A;  4IEC A;  2B3H A;  1Y1N A;  3IU9 A;  3PKC A;  3IU8 A;  2Q94 A;  5JFR A;  2GG0 A;  5D6F A;  3TAV A;  1M35 A;  4U69 A;  2BHD A;  2GGB A;  1W7V A;  2V3Y A;  2GU7 A;  1WLR A;  4U6W A;  2OAZ A;  2HOW A;  2BWY A;  4S2T P;  4Z7M A;  5CLS A;  4S01 A;  2ADU A;  3FM3 A;  1BN5 A;  3BIT A;  1C24 A;  2Q96 A;  2MAT A;  4U73 A;  3RVA A;  2GGC A;  4KM3 A;  4IDY A;  5CDV A;  2BB7 A;  1WKM A;  1WN1 A;  3MR1 A;  4U6J A;  4EGE A;  4A6V A;  1N51 A;  1B6A A;  4FLI A;  4U71 A;  3S6B A;  5E2C A;  2B3L A;  1YW7 A;  2GU5 A;  1KQ0 A;  2GG9 A;  4U1B A;  5JHU A;  4R60 A;  1YJ3 A;  1A16 A;  2P99 A;  4ZNG A;  5D6E A;  3IL0 A;  4IKS A;  4U6Z A;  3PKA A;  4QR8 A;  4FLJ A;  2IW2 A;  1YW9 A;  4JUQ A;  3PN9 A;  2ZSG A;  3FMR A;  4S00 A;  1QXW A;  2EA4 A;  3ROR A;  4U6E A;  2GG3 A;  2EVO A;  2DFI A;  4PV4 A;  3PKE A;  1QXY A;  4A6W A;  2OKN A;  3BIP A;  1KQ9 A;  1XNZ A;  3TB5 A;  2V3Z A;  5CNX A;  2GG8 A;  2Q95 A;  2B3K A;  5CIK A;  3OVK A;  4FO7 A;  4U6C A;  4U70 A;  3CTZ A;  1YW8 A;  1QXZ A;  1WL6 A;  4S2R P;  2GG5 A;  5E5B A;  4ZWU A;  2EA2 A;  2GG7 A;  3MAT A;  1XGS A;  4IU6 A;  3BIQ A;  2EVM A;  1C21 A;  3FMQ A;  3L7G A;  2BWX A;  1KP0 A;  4IPA A;  1QZY A;  2EVC A;  2BWU A;  1WY2 A;  4MAT A;  3D27 A;  3L24 A;  2GU6 A;  2GTX A;  4U75 A;  4IF7 A;  2Q92 A;  2BWS A;  4OOK A;  2GU4 A;  4HXX A;  2BWT A;  4IKU A;  4RZY A;  4PNC A;  5FCF A;  2Q8K A;  1WL9 A;  3O5V A;  1C23 A;  1R5G A;  3IG4 A;  1PV9 A;  5FCH A;  4B28 A;  4FO8 A;  2GZ5 A;  1C22 A;  1R58 A;  4IKT A;  3PKD A;  4RGZ 1;  4U76 A;  2BWW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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