4ZWOA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f
Total Genus 158
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
158
sequence length
439
structure length
425
Chain Sequence
NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNIVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQVHDVGGFMADEQGAFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords organophosphate anhydrolase/prolidase
total genus 158
structure length 425
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwoA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwoA02
3PKEA 2Q92A 3FM3A 5JHUA 1R58A 4IKTA 3S6BA 2V3ZA 4IPAA 5CNXA 4ZNGA 4U71A 3QOCA 2GA2A 2V3YA 1YW8A 1YW7A 2GG2A 2EA2A 2GG7A 2BHDA 5CIKA 2P9AA 4FLIA 4JUQA 1QXYA 4OOKA 5CDEA 2NQ7A 3MATA 3PN9A 1C22A 1XGNA 5D6FA 3BIQA 3TB5A 4U73A 5CLSA 2Q96A 2BB7A 4HXXA 3D27A 4IKRA 3IU9A 1WLRA 2BHCA 2BWTA 2HOWA 1KP0A 3BITA 1KQ0A 3MR1A 3CB6A 4U6WA 2MATA 3FMRA 2ZSGA 2GGCA 2OAZA 2Q94A 1CHMA 5CDLA 3CB5A 1B59A 2BWVA 1C23A 3O5VA 4RZZA 3MX6A 2ADUA 1XGMA 1PV9A 4FLJA 1N51A 2BHAA 2BN7A 1C27A 4IU6A 4U6JA 1WKMA 4U70A 2GU5A 4FO8A 2GTXA 1BOAA 4ZWUA 1XNZA 5JFRA 2EA4A 4FKCA 4A6VA 1WL6A 1C24A 1W7VA 4S01A 4U1BA 4FLKA 2BWXA 1R5HA 2P99A 1YJ3A 4ZWPA 1WL9A 4S2RP 2GG3A 2B3KA 2BH3A 5FCFA 1W2MA 1QZYA 1QXWA 4PV4A 2GG8A 4PNCA 2GGBA 2GU6A 5E5BA 1JAWA 1M35A 4FLLA 2BWWA 1WN1A 3TAVA 2Q95A 4FO7A 1WY2A 2GG0A 2V6CA 4U75A 4A6WA 3IL0A 4IKSA 3I7MA 2DFIA 1Y1NA 1A16A 3CTZA 5FCHA 3PKAA 3PKDA 2GU7A 4U76A 4IKUA 5D6EA 2GZ5A 2Q93A 3RORA 2B3LA 2IW2A 3PKCA 3IU8A 4QR8A 2EVMA 4U69A 4IECA 3RVAA 1B6AA 4EGEA 4ZWOA 4U6ZA 4Z7MA 2EVCA 3PKBA 3BIPA 3Q6DA 1WBQA 2OKNA 3OVKA 1KQ9A 1QXZA 2Q8KA 4U6EA 1MATA 1C21A 3IG4A 4U6CA 1XGSA 3FMQA 5E2CA 2P98A 3L24A 3OOOA 1O0XA 4IDYA 5JI6A 2V3XA 1R5GA 4S00A 2B3HA 2GU4A 2EVOA 4RZYA 4B28A 2BWYA 3PEBA 5CE6A 2BWUA 2GG5A 4IF7A 2BWSA 5CDVA 4RGZ1 1YW9A 4KM3A 4MATA 3L7GA 4R60A 1BN5A 4S2TP 3IU7A 1XGOA 2NQ6A 2BHBA 4FUKA 2G6PA 1YVMA 2GG9A
chains in the Genus database with same CATH superfamily
3PKEA 2Q92A 3FM3A 5JHUA 1R58A 4IKTA 3S6BA 2V3ZA 4IPAA 5CNXA 4ZNGA 4U71A 3QOCA 2GA2A 2V3YA 1YW8A 1YW7A 2GG2A 2EA2A 2GG7A 2BHDA 5CIKA 2P9AA 4FLIA 4JUQA 1QXYA 4OOKA 5CDEA 2NQ7A 3MATA 3PN9A 1C22A 1XGNA 5D6FA 3BIQA 3TB5A 4U73A 5CLSA 2Q96A 2BB7A 4HXXA 3D27A 4IKRA 3IU9A 1WLRA 2BHCA 2BWTA 2HOWA 1KP0A 3BITA 1KQ0A 3MR1A 3CB6A 4U6WA 2MATA 3FMRA 2ZSGA 2GGCA 2OAZA 2Q94A 1CHMA 5CDLA 3CB5A 1B59A 2BWVA 1C23A 3O5VA 4RZZA 3MX6A 2ADUA 1XGMA 1PV9A 4FLJA 1N51A 2BHAA 2BN7A 1C27A 4IU6A 4U6JA 1WKMA 4U70A 2GU5A 4FO8A 2GTXA 1BOAA 4ZWUA 1XNZA 5JFRA 2EA4A 4FKCA 4A6VA 1WL6A 1C24A 1W7VA 4S01A 4U1BA 4FLKA 2BWXA 1R5HA 2P99A 1YJ3A 4ZWPA 1WL9A 4S2RP 2GG3A 2B3KA 2BH3A 5FCFA 1W2MA 1QZYA 1QXWA 4PV4A 2GG8A 4PNCA 2GGBA 2GU6A 5E5BA 1JAWA 1M35A 4FLLA 2BWWA 1WN1A 3TAVA 2Q95A 4FO7A 1WY2A 2GG0A 2V6CA 4U75A 4A6WA 3IL0A 4IKSA 3I7MA 2DFIA 1Y1NA 1A16A 3CTZA 5FCHA 3PKAA 3PKDA 2GU7A 4U76A 4IKUA 5D6EA 2GZ5A 2Q93A 3RORA 2B3LA 2IW2A 3PKCA 3IU8A 4QR8A 2EVMA 4U69A 4IECA 3RVAA 1B6AA 4EGEA 4ZWOA 4U6ZA 4Z7MA 2EVCA 3PKBA 3BIPA 3Q6DA 1WBQA 2OKNA 3OVKA 1KQ9A 1QXZA 2Q8KA 4U6EA 1MATA 1C21A 3IG4A 4U6CA 1XGSA 3FMQA 5E2CA 2P98A 3L24A 3OOOA 1O0XA 4IDYA 5JI6A 2V3XA 1R5GA 4S00A 2B3HA 2GU4A 2EVOA 4RZYA 4B28A 2BWYA 3PEBA 5CE6A 2BWUA 2GG5A 4IF7A 2BWSA 5CDVA 4RGZ1 1YW9A 4KM3A 4MATA 3L7GA 4R60A 1BN5A 4S2TP 3IU7A 1XGOA 2NQ6A 2BHBA 4FUKA 2G6PA 1YVMA 2GG9A
chains in the Genus database with same CATH topology
3PKEA 2Q92A 3FM3A 5JHUA 1R58A 4IKTA 3S6BA 2V3ZA 4IPAA 5CNXA 4ZNGA 4U71A 3QOCA 2GA2A 2V3YA 1YW8A 1YW7A 2GG2A 2EA2A 2GG7A 2BHDA 5CIKA 2P9AA 4FLIA 4JUQA 1QXYA 4OOKA 5CDEA 2NQ7A 3MATA 3PN9A 1C22A 1XGNA 5D6FA 3BIQA 3TB5A 4U73A 5CLSA 2Q96A 2BB7A 4HXXA 3D27A 4IKRA 3IU9A 1WLRA 2BHCA 2BWTA 2HOWA 1KP0A 3BITA 1KQ0A 3MR1A 3CB6A 4U6WA 2MATA 3FMRA 2ZSGA 2GGCA 2OAZA 2Q94A 1CHMA 5CDLA 3CB5A 1B59A 2BWVA 1C23A 3O5VA 4RZZA 3MX6A 2ADUA 1XGMA 1PV9A 4FLJA 1N51A 2BHAA 2BN7A 1C27A 4IU6A 4U6JA 1WKMA 4U70A 2GU5A 4FO8A 2GTXA 1BOAA 4ZWUA 1XNZA 5JFRA 2EA4A 4FKCA 4A6VA 1WL6A 1C24A 1W7VA 4S01A 4U1BA 4FLKA 2BWXA 1R5HA 2P99A 1YJ3A 4ZWPA 1WL9A 4S2RP 2GG3A 2B3KA 2BH3A 5FCFA 1W2MA 1QZYA 1QXWA 4PV4A 2GG8A 4PNCA 2GGBA 2GU6A 5E5BA 1JAWA 1M35A 4FLLA 2BWWA 1WN1A 3TAVA 2Q95A 4FO7A 1WY2A 2GG0A 2V6CA 4U75A 4A6WA 3IL0A 4IKSA 3I7MA 2DFIA 1Y1NA 1A16A 3CTZA 5FCHA 3PKAA 3PKDA 2GU7A 4U76A 4IKUA 5D6EA 2GZ5A 2Q93A 3RORA 2B3LA 2IW2A 3PKCA 3IU8A 4QR8A 2EVMA 4U69A 4IECA 3RVAA 1B6AA 4EGEA 4ZWOA 4U6ZA 4Z7MA 2EVCA 3PKBA 3BIPA 3Q6DA 1WBQA 2OKNA 3OVKA 1KQ9A 1QXZA 2Q8KA 4U6EA 1MATA 1C21A 3IG4A 4U6CA 1XGSA 3FMQA 5E2CA 2P98A 3L24A 3OOOA 1O0XA 4IDYA 5JI6A 2V3XA 1R5GA 4S00A 2B3HA 2GU4A 2EVOA 4RZYA 4B28A 2BWYA 3PEBA 5CE6A 2BWUA 2GG5A 4IF7A 2BWSA 5CDVA 4RGZ1 1YW9A 4KM3A 4MATA 3L7GA 4R60A 1BN5A 4S2TP 3IU7A 1XGOA 2NQ6A 2BHBA 4FUKA 2G6PA 1YVMA 2GG9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PKE A;  2Q92 A;  3FM3 A;  5JHU A;  1R58 A;  4IKT A;  3S6B A;  2V3Z A;  4IPA A;  5CNX A;  4ZNG A;  4U71 A;  3QOC A;  2GA2 A;  2V3Y A;  1YW8 A;  1YW7 A;  2GG2 A;  2EA2 A;  2GG7 A;  2BHD A;  5CIK A;  2P9A A;  4FLI A;  4JUQ A;  1QXY A;  4OOK A;  5CDE A;  2NQ7 A;  3MAT A;  3PN9 A;  1C22 A;  1XGN A;  5D6F A;  3BIQ A;  3TB5 A;  4U73 A;  5CLS A;  2Q96 A;  2BB7 A;  4HXX A;  3D27 A;  4IKR A;  3IU9 A;  1WLR A;  2BHC A;  2BWT A;  2HOW A;  1KP0 A;  3BIT A;  1KQ0 A;  3MR1 A;  3CB6 A;  4U6W A;  2MAT A;  3FMR A;  2ZSG A;  2GGC A;  2OAZ A;  2Q94 A;  1CHM A;  5CDL A;  3CB5 A;  1B59 A;  2BWV A;  1C23 A;  3O5V A;  4RZZ A;  3MX6 A;  2ADU A;  1XGM A;  1PV9 A;  4FLJ A;  1N51 A;  2BHA A;  2BN7 A;  1C27 A;  4IU6 A;  4U6J A;  1WKM A;  4U70 A;  2GU5 A;  4FO8 A;  2GTX A;  1BOA A;  4ZWU A;  1XNZ A;  5JFR A;  2EA4 A;  4FKC A;  4A6V A;  1WL6 A;  1C24 A;  1W7V A;  4S01 A;  4U1B A;  4FLK A;  2BWX A;  1R5H A;  2P99 A;  1YJ3 A;  4ZWP A;  1WL9 A;  4S2R P;  2GG3 A;  2B3K A;  2BH3 A;  5FCF A;  1W2M A;  1QZY A;  1QXW A;  4PV4 A;  2GG8 A;  4PNC A;  2GGB A;  2GU6 A;  5E5B A;  1JAW A;  1M35 A;  4FLL A;  2BWW A;  1WN1 A;  3TAV A;  2Q95 A;  4FO7 A;  1WY2 A;  2GG0 A;  2V6C A;  4U75 A;  4A6W A;  3IL0 A;  4IKS A;  3I7M A;  2DFI A;  1Y1N A;  1A16 A;  3CTZ A;  5FCH A;  3PKA A;  3PKD A;  2GU7 A;  4U76 A;  4IKU A;  5D6E A;  2GZ5 A;  2Q93 A;  3ROR A;  2B3L A;  2IW2 A;  3PKC A;  3IU8 A;  4QR8 A;  2EVM A;  4U69 A;  4IEC A;  3RVA A;  1B6A A;  4EGE A;  4ZWO A;  4U6Z A;  4Z7M A;  2EVC A;  3PKB A;  3BIP A;  3Q6D A;  1WBQ A;  2OKN A;  3OVK A;  1KQ9 A;  1QXZ A;  2Q8K A;  4U6E A;  1MAT A;  1C21 A;  3IG4 A;  4U6C A;  1XGS A;  3FMQ A;  5E2C A;  2P98 A;  3L24 A;  3OOO A;  1O0X A;  4IDY A;  5JI6 A;  2V3X A;  1R5G A;  4S00 A;  2B3H A;  2GU4 A;  2EVO A;  4RZY A;  4B28 A;  2BWY A;  3PEB A;  5CE6 A;  2BWU A;  2GG5 A;  4IF7 A;  2BWS A;  5CDV A;  4RGZ 1;  1YW9 A;  4KM3 A;  4MAT A;  3L7G A;  4R60 A;  1BN5 A;  4S2T P;  3IU7 A;  1XGO A;  2NQ6 A;  2BHB A;  4FUK A;  2G6P A;  1YVM A;  2GG9 A; 
#chains in the Genus database with same CATH topology
 3PKE A;  2Q92 A;  3FM3 A;  5JHU A;  1R58 A;  4IKT A;  3S6B A;  2V3Z A;  4IPA A;  5CNX A;  4ZNG A;  4U71 A;  3QOC A;  2GA2 A;  2V3Y A;  1YW8 A;  1YW7 A;  2GG2 A;  2EA2 A;  2GG7 A;  2BHD A;  5CIK A;  2P9A A;  4FLI A;  4JUQ A;  1QXY A;  4OOK A;  5CDE A;  2NQ7 A;  3MAT A;  3PN9 A;  1C22 A;  1XGN A;  5D6F A;  3BIQ A;  3TB5 A;  4U73 A;  5CLS A;  2Q96 A;  2BB7 A;  4HXX A;  3D27 A;  4IKR A;  3IU9 A;  1WLR A;  2BHC A;  2BWT A;  2HOW A;  1KP0 A;  3BIT A;  1KQ0 A;  3MR1 A;  3CB6 A;  4U6W A;  2MAT A;  3FMR A;  2ZSG A;  2GGC A;  2OAZ A;  2Q94 A;  1CHM A;  5CDL A;  3CB5 A;  1B59 A;  2BWV A;  1C23 A;  3O5V A;  4RZZ A;  3MX6 A;  2ADU A;  1XGM A;  1PV9 A;  4FLJ A;  1N51 A;  2BHA A;  2BN7 A;  1C27 A;  4IU6 A;  4U6J A;  1WKM A;  4U70 A;  2GU5 A;  4FO8 A;  2GTX A;  1BOA A;  4ZWU A;  1XNZ A;  5JFR A;  2EA4 A;  4FKC A;  4A6V A;  1WL6 A;  1C24 A;  1W7V A;  4S01 A;  4U1B A;  4FLK A;  2BWX A;  1R5H A;  2P99 A;  1YJ3 A;  4ZWP A;  1WL9 A;  4S2R P;  2GG3 A;  2B3K A;  2BH3 A;  5FCF A;  1W2M A;  1QZY A;  1QXW A;  4PV4 A;  2GG8 A;  4PNC A;  2GGB A;  2GU6 A;  5E5B A;  1JAW A;  1M35 A;  4FLL A;  2BWW A;  1WN1 A;  3TAV A;  2Q95 A;  4FO7 A;  1WY2 A;  2GG0 A;  2V6C A;  4U75 A;  4A6W A;  3IL0 A;  4IKS A;  3I7M A;  2DFI A;  1Y1N A;  1A16 A;  3CTZ A;  5FCH A;  3PKA A;  3PKD A;  2GU7 A;  4U76 A;  4IKU A;  5D6E A;  2GZ5 A;  2Q93 A;  3ROR A;  2B3L A;  2IW2 A;  3PKC A;  3IU8 A;  4QR8 A;  2EVM A;  4U69 A;  4IEC A;  3RVA A;  1B6A A;  4EGE A;  4ZWO A;  4U6Z A;  4Z7M A;  2EVC A;  3PKB A;  3BIP A;  3Q6D A;  1WBQ A;  2OKN A;  3OVK A;  1KQ9 A;  1QXZ A;  2Q8K A;  4U6E A;  1MAT A;  1C21 A;  3IG4 A;  4U6C A;  1XGS A;  3FMQ A;  5E2C A;  2P98 A;  3L24 A;  3OOO A;  1O0X A;  4IDY A;  5JI6 A;  2V3X A;  1R5G A;  4S00 A;  2B3H A;  2GU4 A;  2EVO A;  4RZY A;  4B28 A;  2BWY A;  3PEB A;  5CE6 A;  2BWU A;  2GG5 A;  4IF7 A;  2BWS A;  5CDV A;  4RGZ 1;  1YW9 A;  4KM3 A;  4MAT A;  3L7G A;  4R60 A;  1BN5 A;  4S2T P;  3IU7 A;  1XGO A;  2NQ6 A;  2BHB A;  4FUK A;  2G6P A;  1YVM A;  2GG9 A; 
#chains in the Genus database with same CATH homology
 3PKE A;  2Q92 A;  3FM3 A;  5JHU A;  1R58 A;  4IKT A;  3S6B A;  2V3Z A;  4IPA A;  5CNX A;  4ZNG A;  4U71 A;  3QOC A;  2GA2 A;  2V3Y A;  1YW8 A;  1YW7 A;  2GG2 A;  2EA2 A;  2GG7 A;  2BHD A;  5CIK A;  2P9A A;  4FLI A;  4JUQ A;  1QXY A;  4OOK A;  5CDE A;  2NQ7 A;  3MAT A;  3PN9 A;  1C22 A;  1XGN A;  5D6F A;  3BIQ A;  3TB5 A;  4U73 A;  5CLS A;  2Q96 A;  2BB7 A;  4HXX A;  3D27 A;  4IKR A;  3IU9 A;  1WLR A;  2BHC A;  2BWT A;  2HOW A;  1KP0 A;  3BIT A;  1KQ0 A;  3MR1 A;  3CB6 A;  4U6W A;  2MAT A;  3FMR A;  2ZSG A;  2GGC A;  2OAZ A;  2Q94 A;  1CHM A;  5CDL A;  3CB5 A;  1B59 A;  2BWV A;  1C23 A;  3O5V A;  4RZZ A;  3MX6 A;  2ADU A;  1XGM A;  1PV9 A;  4FLJ A;  1N51 A;  2BHA A;  2BN7 A;  1C27 A;  4IU6 A;  4U6J A;  1WKM A;  4U70 A;  2GU5 A;  4FO8 A;  2GTX A;  1BOA A;  4ZWU A;  1XNZ A;  5JFR A;  2EA4 A;  4FKC A;  4A6V A;  1WL6 A;  1C24 A;  1W7V A;  4S01 A;  4U1B A;  4FLK A;  2BWX A;  1R5H A;  2P99 A;  1YJ3 A;  4ZWP A;  1WL9 A;  4S2R P;  2GG3 A;  2B3K A;  2BH3 A;  5FCF A;  1W2M A;  1QZY A;  1QXW A;  4PV4 A;  2GG8 A;  4PNC A;  2GGB A;  2GU6 A;  5E5B A;  1JAW A;  1M35 A;  4FLL A;  2BWW A;  1WN1 A;  3TAV A;  2Q95 A;  4FO7 A;  1WY2 A;  2GG0 A;  2V6C A;  4U75 A;  4A6W A;  3IL0 A;  4IKS A;  3I7M A;  2DFI A;  1Y1N A;  1A16 A;  3CTZ A;  5FCH A;  3PKA A;  3PKD A;  2GU7 A;  4U76 A;  4IKU A;  5D6E A;  2GZ5 A;  2Q93 A;  3ROR A;  2B3L A;  2IW2 A;  3PKC A;  3IU8 A;  4QR8 A;  2EVM A;  4U69 A;  4IEC A;  3RVA A;  1B6A A;  4EGE A;  4ZWO A;  4U6Z A;  4Z7M A;  2EVC A;  3PKB A;  3BIP A;  3Q6D A;  1WBQ A;  2OKN A;  3OVK A;  1KQ9 A;  1QXZ A;  2Q8K A;  4U6E A;  1MAT A;  1C21 A;  3IG4 A;  4U6C A;  1XGS A;  3FMQ A;  5E2C A;  2P98 A;  3L24 A;  3OOO A;  1O0X A;  4IDY A;  5JI6 A;  2V3X A;  1R5G A;  4S00 A;  2B3H A;  2GU4 A;  2EVO A;  4RZY A;  4B28 A;  2BWY A;  3PEB A;  5CE6 A;  2BWU A;  2GG5 A;  4IF7 A;  2BWS A;  5CDV A;  4RGZ 1;  1YW9 A;  4KM3 A;  4MAT A;  3L7G A;  4R60 A;  1BN5 A;  4S2T P;  3IU7 A;  1XGO A;  2NQ6 A;  2BHB A;  4FUK A;  2G6P A;  1YVM A;  2GG9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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