4U71A

Hsmetap(f309m) in complex with 1- amino(cyclohexyl)methy)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u71A00
1MATA 2V3ZA 3TB5A 5JHUA 4U75A 1YW7A 2P98A 3PKDA 4PNCA 1QXYA 1B6AA 5JFRA 3L24A 3FMQA 5JI6A 1XNZA 3IG4A 1C27A 4JUQA 2GGCA 3BIQA 3RVAA 1R5GA 2P9AA 4U6EA 4S01A 3CTZA 2GZ5A 4RZZA 5CDEA 2GG0A 2Q8KA 4FUKA 2EVCA 4FLKA 3S6BA 4EGEA 4IECA 3FMRA 5CDLA 4FKCA 2NQ7A 1WL6A 2ADUA 4IDYA 1KP0A 1JAWA 3IU8A 1KQ0A 1R58A 2MATA 4QR8A 5CLSA 4U70A 5D6FA 2GG9A 5CE6A 1C24A 1A16A 2EA2A 4S2TP 3PKBA 2ZSGA 3D27A 2BWUA 5CNXA 4Z7MA 2Q95A 2NQ6A 4KM3A 2P99A 1N51A 4A6WA 2GG2A 5CIKA 5CDVA 1Y1NA 2BHAA 2EVMA 3CB6A 1XGNA 3BITA 5D6EA 2BB7A 4S00A 1WKMA 4FLLA 3PKCA 2GGBA 1XGSA 2B3HA 4U6ZA 3MX6A 5E5BA 4ZWOA 3TAVA 1KQ9A 4B28A 3PKEA 2GTXA 1W2MA 3MATA 2GG5A 2Q92A 1XGOA 2BHBA 2BWWA 4RZYA 4U71A 2BWYA 1B59A 4IPAA 2BWTA 4U69A 1QXWA 4IKTA 2BWVA 4IF7A 1BOAA 1WN1A 2BWSA 4R60A 4U73A 4FO8A 4U76A 2EA4A 1M35A 1QZYA 2GU4A 1C22A 2DFIA 1WY2A 2Q96A 4IU6A 2GU6A 2GG7A 2BWXA 2BHDA 2GG3A 4OOKA 4U1BA 2HOWA 4U6WA 3MR1A 4A6VA 1PV9A 1YJ3A 2OKNA 2GU7A 3CB5A 5FCHA 3IU9A 4S2RP 1C23A 2GU5A 4MATA 2Q94A 2Q93A 3Q6DA 1C21A 1XGMA 3FM3A 2BHCA 3RORA 3L7GA 4ZWPA 1WL9A 1YVMA 3BIPA 1BN5A 3PKAA 4RGZ1 1O0XA 4FLJA 4FO7A 1YW9A 2GA2A 2B3KA 2EVOA 1W7VA 2GG8A 2V3YA 4ZWUA 1CHMA 4IKRA 1R5HA 2BH3A 2BN7A 2V6CA 2G6PA 2V3XA 5FCFA 4IKSA 4FLIA 2OAZA 4U6CA 4ZNGA 1WBQA 4IKUA 1YW8A 4HXXA 2IW2A 1QXZA 3IU7A 4U6JA 2B3LA 4PV4A 1WLRA
chains in the Genus database with same CATH superfamily
1MATA 2V3ZA 3TB5A 5JHUA 4U75A 1YW7A 2P98A 3PKDA 4PNCA 1QXYA 1B6AA 5JFRA 3L24A 3FMQA 5JI6A 1XNZA 3IG4A 1C27A 4JUQA 2GGCA 3BIQA 3RVAA 1R5GA 2P9AA 4U6EA 4S01A 3CTZA 2GZ5A 4RZZA 5CDEA 2GG0A 2Q8KA 4FUKA 2EVCA 4FLKA 3S6BA 4EGEA 4IECA 3FMRA 5CDLA 4FKCA 2NQ7A 1WL6A 2ADUA 4IDYA 1KP0A 1JAWA 3IU8A 1KQ0A 1R58A 2MATA 4QR8A 5CLSA 4U70A 5D6FA 2GG9A 5CE6A 1C24A 1A16A 2EA2A 4S2TP 3PKBA 2ZSGA 3D27A 2BWUA 5CNXA 4Z7MA 2Q95A 2NQ6A 4KM3A 2P99A 1N51A 4A6WA 2GG2A 5CIKA 5CDVA 1Y1NA 2BHAA 2EVMA 3CB6A 1XGNA 3BITA 5D6EA 2BB7A 4S00A 1WKMA 4FLLA 3PKCA 2GGBA 1XGSA 2B3HA 4U6ZA 3MX6A 5E5BA 4ZWOA 3TAVA 1KQ9A 4B28A 3PKEA 2GTXA 1W2MA 3MATA 2GG5A 2Q92A 1XGOA 2BHBA 2BWWA 4RZYA 4U71A 2BWYA 1B59A 4IPAA 2BWTA 4U69A 1QXWA 4IKTA 2BWVA 4IF7A 1BOAA 1WN1A 2BWSA 4R60A 4U73A 4FO8A 4U76A 2EA4A 1M35A 1QZYA 2GU4A 1C22A 2DFIA 1WY2A 2Q96A 4IU6A 2GU6A 2GG7A 2BWXA 2BHDA 2GG3A 4OOKA 4U1BA 2HOWA 4U6WA 3MR1A 4A6VA 1PV9A 1YJ3A 2OKNA 2GU7A 3CB5A 5FCHA 3IU9A 4S2RP 1C23A 2GU5A 4MATA 2Q94A 2Q93A 3Q6DA 1C21A 1XGMA 3FM3A 2BHCA 3RORA 3L7GA 4ZWPA 1WL9A 1YVMA 3BIPA 1BN5A 3PKAA 4RGZ1 1O0XA 4FLJA 4FO7A 1YW9A 2GA2A 2B3KA 2EVOA 1W7VA 2GG8A 2V3YA 4ZWUA 1CHMA 4IKRA 1R5HA 2BH3A 2BN7A 2V6CA 2G6PA 2V3XA 5FCFA 4IKSA 4FLIA 2OAZA 4U6CA 4ZNGA 1WBQA 4IKUA 1YW8A 4HXXA 2IW2A 1QXZA 3IU7A 4U6JA 2B3LA 4PV4A 1WLRA
chains in the Genus database with same CATH topology
1MATA 2V3ZA 3TB5A 5JHUA 4U75A 1YW7A 2P98A 3PKDA 4PNCA 1QXYA 1B6AA 5JFRA 3L24A 3FMQA 5JI6A 1XNZA 3IG4A 1C27A 4JUQA 2GGCA 3BIQA 3RVAA 1R5GA 2P9AA 4U6EA 4S01A 3CTZA 2GZ5A 4RZZA 5CDEA 2GG0A 2Q8KA 4FUKA 2EVCA 4FLKA 3S6BA 4EGEA 4IECA 3FMRA 5CDLA 4FKCA 2NQ7A 1WL6A 2ADUA 4IDYA 1KP0A 1JAWA 3IU8A 1KQ0A 1R58A 2MATA 4QR8A 5CLSA 4U70A 5D6FA 2GG9A 5CE6A 1C24A 1A16A 2EA2A 4S2TP 3PKBA 2ZSGA 3D27A 2BWUA 5CNXA 4Z7MA 2Q95A 2NQ6A 4KM3A 2P99A 1N51A 4A6WA 2GG2A 5CIKA 5CDVA 1Y1NA 2BHAA 2EVMA 3CB6A 1XGNA 3BITA 5D6EA 2BB7A 4S00A 1WKMA 4FLLA 3PKCA 2GGBA 1XGSA 2B3HA 4U6ZA 3MX6A 5E5BA 4ZWOA 3TAVA 1KQ9A 4B28A 3PKEA 2GTXA 1W2MA 3MATA 2GG5A 2Q92A 1XGOA 2BHBA 2BWWA 4RZYA 4U71A 2BWYA 1B59A 4IPAA 2BWTA 4U69A 1QXWA 4IKTA 2BWVA 4IF7A 1BOAA 1WN1A 2BWSA 4R60A 4U73A 4FO8A 4U76A 2EA4A 1M35A 1QZYA 2GU4A 1C22A 2DFIA 1WY2A 2Q96A 4IU6A 2GU6A 2GG7A 2BWXA 2BHDA 2GG3A 4OOKA 4U1BA 2HOWA 4U6WA 3MR1A 4A6VA 1PV9A 1YJ3A 2OKNA 2GU7A 3CB5A 5FCHA 3IU9A 4S2RP 1C23A 2GU5A 4MATA 2Q94A 2Q93A 3Q6DA 1C21A 1XGMA 3FM3A 2BHCA 3RORA 3L7GA 4ZWPA 1WL9A 1YVMA 3BIPA 1BN5A 3PKAA 4RGZ1 1O0XA 4FLJA 4FO7A 1YW9A 2GA2A 2B3KA 2EVOA 1W7VA 2GG8A 2V3YA 4ZWUA 1CHMA 4IKRA 1R5HA 2BH3A 2BN7A 2V6CA 2G6PA 2V3XA 5FCFA 4IKSA 4FLIA 2OAZA 4U6CA 4ZNGA 1WBQA 4IKUA 1YW8A 4HXXA 2IW2A 1QXZA 3IU7A 4U6JA 2B3LA 4PV4A 1WLRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MAT A;  2V3Z A;  3TB5 A;  5JHU A;  4U75 A;  1YW7 A;  2P98 A;  3PKD A;  4PNC A;  1QXY A;  1B6A A;  5JFR A;  3L24 A;  3FMQ A;  5JI6 A;  1XNZ A;  3IG4 A;  1C27 A;  4JUQ A;  2GGC A;  3BIQ A;  3RVA A;  1R5G A;  2P9A A;  4U6E A;  4S01 A;  3CTZ A;  2GZ5 A;  4RZZ A;  5CDE A;  2GG0 A;  2Q8K A;  4FUK A;  2EVC A;  4FLK A;  3S6B A;  4EGE A;  4IEC A;  3FMR A;  5CDL A;  4FKC A;  2NQ7 A;  1WL6 A;  2ADU A;  4IDY A;  1KP0 A;  1JAW A;  3IU8 A;  1KQ0 A;  1R58 A;  2MAT A;  4QR8 A;  5CLS A;  4U70 A;  5D6F A;  2GG9 A;  5CE6 A;  1C24 A;  1A16 A;  2EA2 A;  4S2T P;  3PKB A;  2ZSG A;  3D27 A;  2BWU A;  5CNX A;  4Z7M A;  2Q95 A;  2NQ6 A;  4KM3 A;  2P99 A;  1N51 A;  4A6W A;  2GG2 A;  5CIK A;  5CDV A;  1Y1N A;  2BHA A;  2EVM A;  3CB6 A;  1XGN A;  3BIT A;  5D6E A;  2BB7 A;  4S00 A;  1WKM A;  4FLL A;  3PKC A;  2GGB A;  1XGS A;  2B3H A;  4U6Z A;  3MX6 A;  5E5B A;  4ZWO A;  3TAV A;  1KQ9 A;  4B28 A;  3PKE A;  2GTX A;  1W2M A;  3MAT A;  2GG5 A;  2Q92 A;  1XGO A;  2BHB A;  2BWW A;  4RZY A;  4U71 A;  2BWY A;  1B59 A;  4IPA A;  2BWT A;  4U69 A;  1QXW A;  4IKT A;  2BWV A;  4IF7 A;  1BOA A;  1WN1 A;  2BWS A;  4R60 A;  4U73 A;  4FO8 A;  4U76 A;  2EA4 A;  1M35 A;  1QZY A;  2GU4 A;  1C22 A;  2DFI A;  1WY2 A;  2Q96 A;  4IU6 A;  2GU6 A;  2GG7 A;  2BWX A;  2BHD A;  2GG3 A;  4OOK A;  4U1B A;  2HOW A;  4U6W A;  3MR1 A;  4A6V A;  1PV9 A;  1YJ3 A;  2OKN A;  2GU7 A;  3CB5 A;  5FCH A;  3IU9 A;  4S2R P;  1C23 A;  2GU5 A;  4MAT A;  2Q94 A;  2Q93 A;  3Q6D A;  1C21 A;  1XGM A;  3FM3 A;  2BHC A;  3ROR A;  3L7G A;  4ZWP A;  1WL9 A;  1YVM A;  3BIP A;  1BN5 A;  3PKA A;  4RGZ 1;  1O0X A;  4FLJ A;  4FO7 A;  1YW9 A;  2GA2 A;  2B3K A;  2EVO A;  1W7V A;  2GG8 A;  2V3Y A;  4ZWU A;  1CHM A;  4IKR A;  1R5H A;  2BH3 A;  2BN7 A;  2V6C A;  2G6P A;  2V3X A;  5FCF A;  4IKS A;  4FLI A;  2OAZ A;  4U6C A;  4ZNG A;  1WBQ A;  4IKU A;  1YW8 A;  4HXX A;  2IW2 A;  1QXZ A;  3IU7 A;  4U6J A;  2B3L A;  4PV4 A;  1WLR A; 
#chains in the Genus database with same CATH topology
 1MAT A;  2V3Z A;  3TB5 A;  5JHU A;  4U75 A;  1YW7 A;  2P98 A;  3PKD A;  4PNC A;  1QXY A;  1B6A A;  5JFR A;  3L24 A;  3FMQ A;  5JI6 A;  1XNZ A;  3IG4 A;  1C27 A;  4JUQ A;  2GGC A;  3BIQ A;  3RVA A;  1R5G A;  2P9A A;  4U6E A;  4S01 A;  3CTZ A;  2GZ5 A;  4RZZ A;  5CDE A;  2GG0 A;  2Q8K A;  4FUK A;  2EVC A;  4FLK A;  3S6B A;  4EGE A;  4IEC A;  3FMR A;  5CDL A;  4FKC A;  2NQ7 A;  1WL6 A;  2ADU A;  4IDY A;  1KP0 A;  1JAW A;  3IU8 A;  1KQ0 A;  1R58 A;  2MAT A;  4QR8 A;  5CLS A;  4U70 A;  5D6F A;  2GG9 A;  5CE6 A;  1C24 A;  1A16 A;  2EA2 A;  4S2T P;  3PKB A;  2ZSG A;  3D27 A;  2BWU A;  5CNX A;  4Z7M A;  2Q95 A;  2NQ6 A;  4KM3 A;  2P99 A;  1N51 A;  4A6W A;  2GG2 A;  5CIK A;  5CDV A;  1Y1N A;  2BHA A;  2EVM A;  3CB6 A;  1XGN A;  3BIT A;  5D6E A;  2BB7 A;  4S00 A;  1WKM A;  4FLL A;  3PKC A;  2GGB A;  1XGS A;  2B3H A;  4U6Z A;  3MX6 A;  5E5B A;  4ZWO A;  3TAV A;  1KQ9 A;  4B28 A;  3PKE A;  2GTX A;  1W2M A;  3MAT A;  2GG5 A;  2Q92 A;  1XGO A;  2BHB A;  2BWW A;  4RZY A;  4U71 A;  2BWY A;  1B59 A;  4IPA A;  2BWT A;  4U69 A;  1QXW A;  4IKT A;  2BWV A;  4IF7 A;  1BOA A;  1WN1 A;  2BWS A;  4R60 A;  4U73 A;  4FO8 A;  4U76 A;  2EA4 A;  1M35 A;  1QZY A;  2GU4 A;  1C22 A;  2DFI A;  1WY2 A;  2Q96 A;  4IU6 A;  2GU6 A;  2GG7 A;  2BWX A;  2BHD A;  2GG3 A;  4OOK A;  4U1B A;  2HOW A;  4U6W A;  3MR1 A;  4A6V A;  1PV9 A;  1YJ3 A;  2OKN A;  2GU7 A;  3CB5 A;  5FCH A;  3IU9 A;  4S2R P;  1C23 A;  2GU5 A;  4MAT A;  2Q94 A;  2Q93 A;  3Q6D A;  1C21 A;  1XGM A;  3FM3 A;  2BHC A;  3ROR A;  3L7G A;  4ZWP A;  1WL9 A;  1YVM A;  3BIP A;  1BN5 A;  3PKA A;  4RGZ 1;  1O0X A;  4FLJ A;  4FO7 A;  1YW9 A;  2GA2 A;  2B3K A;  2EVO A;  1W7V A;  2GG8 A;  2V3Y A;  4ZWU A;  1CHM A;  4IKR A;  1R5H A;  2BH3 A;  2BN7 A;  2V6C A;  2G6P A;  2V3X A;  5FCF A;  4IKS A;  4FLI A;  2OAZ A;  4U6C A;  4ZNG A;  1WBQ A;  4IKU A;  1YW8 A;  4HXX A;  2IW2 A;  1QXZ A;  3IU7 A;  4U6J A;  2B3L A;  4PV4 A;  1WLR A; 
#chains in the Genus database with same CATH homology
 1MAT A;  2V3Z A;  3TB5 A;  5JHU A;  4U75 A;  1YW7 A;  2P98 A;  3PKD A;  4PNC A;  1QXY A;  1B6A A;  5JFR A;  3L24 A;  3FMQ A;  5JI6 A;  1XNZ A;  3IG4 A;  1C27 A;  4JUQ A;  2GGC A;  3BIQ A;  3RVA A;  1R5G A;  2P9A A;  4U6E A;  4S01 A;  3CTZ A;  2GZ5 A;  4RZZ A;  5CDE A;  2GG0 A;  2Q8K A;  4FUK A;  2EVC A;  4FLK A;  3S6B A;  4EGE A;  4IEC A;  3FMR A;  5CDL A;  4FKC A;  2NQ7 A;  1WL6 A;  2ADU A;  4IDY A;  1KP0 A;  1JAW A;  3IU8 A;  1KQ0 A;  1R58 A;  2MAT A;  4QR8 A;  5CLS A;  4U70 A;  5D6F A;  2GG9 A;  5CE6 A;  1C24 A;  1A16 A;  2EA2 A;  4S2T P;  3PKB A;  2ZSG A;  3D27 A;  2BWU A;  5CNX A;  4Z7M A;  2Q95 A;  2NQ6 A;  4KM3 A;  2P99 A;  1N51 A;  4A6W A;  2GG2 A;  5CIK A;  5CDV A;  1Y1N A;  2BHA A;  2EVM A;  3CB6 A;  1XGN A;  3BIT A;  5D6E A;  2BB7 A;  4S00 A;  1WKM A;  4FLL A;  3PKC A;  2GGB A;  1XGS A;  2B3H A;  4U6Z A;  3MX6 A;  5E5B A;  4ZWO A;  3TAV A;  1KQ9 A;  4B28 A;  3PKE A;  2GTX A;  1W2M A;  3MAT A;  2GG5 A;  2Q92 A;  1XGO A;  2BHB A;  2BWW A;  4RZY A;  4U71 A;  2BWY A;  1B59 A;  4IPA A;  2BWT A;  4U69 A;  1QXW A;  4IKT A;  2BWV A;  4IF7 A;  1BOA A;  1WN1 A;  2BWS A;  4R60 A;  4U73 A;  4FO8 A;  4U76 A;  2EA4 A;  1M35 A;  1QZY A;  2GU4 A;  1C22 A;  2DFI A;  1WY2 A;  2Q96 A;  4IU6 A;  2GU6 A;  2GG7 A;  2BWX A;  2BHD A;  2GG3 A;  4OOK A;  4U1B A;  2HOW A;  4U6W A;  3MR1 A;  4A6V A;  1PV9 A;  1YJ3 A;  2OKN A;  2GU7 A;  3CB5 A;  5FCH A;  3IU9 A;  4S2R P;  1C23 A;  2GU5 A;  4MAT A;  2Q94 A;  2Q93 A;  3Q6D A;  1C21 A;  1XGM A;  3FM3 A;  2BHC A;  3ROR A;  3L7G A;  4ZWP A;  1WL9 A;  1YVM A;  3BIP A;  1BN5 A;  3PKA A;  4RGZ 1;  1O0X A;  4FLJ A;  4FO7 A;  1YW9 A;  2GA2 A;  2B3K A;  2EVO A;  1W7V A;  2GG8 A;  2V3Y A;  4ZWU A;  1CHM A;  4IKR A;  1R5H A;  2BH3 A;  2BN7 A;  2V6C A;  2G6P A;  2V3X A;  5FCF A;  4IKS A;  4FLI A;  2OAZ A;  4U6C A;  4ZNG A;  1WBQ A;  4IKU A;  1YW8 A;  4HXX A;  2IW2 A;  1QXZ A;  3IU7 A;  4U6J A;  2B3L A;  4PV4 A;  1WLR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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