4U71A

Hsmetap(f309m) in complex with 1- amino(cyclohexyl)methy)phosphonic acid
Total Genus 99
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u71A00
4Z7MA 2P98A 2GG0A 4RZZA 1WLRA 2G6PA 2GU5A 2Q96A 3BIQA 3TB5A 4U75A 1XGMA 2GG9A 3MATA 4IKRA 4R60A 2B3LA 3PKDA 4RZYA 4MATA 4U6JA 4S00A 2V6CA 4QR8A 4IKUA 5CLSA 1Y1NA 4ZWPA 1O0XA 2V3ZA 1BN5A 2GU7A 1R5HA 3PKBA 4EGEA 2ADUA 3IU8A 3BIPA 2Q94A 2GU4A 2HOWA 1YW8A 1WKMA 3CB6A 5JHUA 2Q93A 1YVMA 2B3KA 4RGZ1 4U73A 3Q6DA 4FLJA 4U71A 2OAZA 1QXZA 4U6WA 2GGCA 3S6BA 1WN1A 1XGNA 1QXYA 3IU9A 4S01A 4ZWOA 5JI6A 1XGSA 2GG3A 2V3YA 1KQ9A 2GA2A 5CDLA 4IPAA 4IKSA 5D6EA 5CDEA 2BHAA 2BHCA 1WY2A 2EVMA 2GG2A 4U69A 2Q95A 4ZNGA 1WL9A 5CDVA 2BWSA 2GU6A 1B59A 1C21A 3IG4A 3BITA 4U70A 2P9AA 2OKNA 1QXWA 4IKTA 5JFRA 4FO8A 2BWUA 2GZ5A 2NQ6A 1XNZA 2BHDA 1C22A 2BN7A 1R5GA 2EVCA 5CE6A 1YJ3A 1KQ0A 3RVAA 2ZSGA 3CTZA 5CIKA 2Q92A 4ZWUA 3PKCA 4FLLA 5FCFA 2GG7A 1C23A 4FO7A 1YW7A 1PV9A 4OOKA 2MATA 2GG8A 2BWYA 1C27A 3D27A 4PNCA 2P99A 1R58A 2GGBA 4A6VA 4S2RP 3CB5A 4KM3A 2BWVA 4PV4A 2NQ7A 3MX6A 3PKEA 1YW9A 2BH3A 2DFIA 5CNXA 4FLKA 2B3HA 2BWWA 4FKCA 3FM3A 2GG5A 3MR1A 2Q8KA 4IF7A 1A16A 4U6ZA 1WBQA 1BOAA 4IU6A 4U6EA 1MATA 1C24A 2IW2A 4JUQA 1W7VA 2EA4A 2V3XA 3FMRA 4U76A 3RORA 1N51A 2BHBA 4U1BA 2EA2A 1W2MA 3PKAA 5D6FA 1QZYA 3L7GA 2BWXA 4U6CA 2EVOA 3L24A 5FCHA 2GTXA 1KP0A 4FLIA 4HXXA 1CHMA 4IDYA 2BB7A 1M35A 2BWTA 3TAVA 1XGOA 4IECA 4A6WA 5E5BA 4B28A 4FUKA 3FMQA 4S2TP 1B6AA 1WL6A 1JAWA 3IU7A
chains in the Genus database with same CATH superfamily
4Z7MA 2P98A 2GG0A 4RZZA 1WLRA 2G6PA 2GU5A 2Q96A 3BIQA 3TB5A 4U75A 1XGMA 2GG9A 3MATA 4IKRA 4R60A 2B3LA 3PKDA 4RZYA 4MATA 4U6JA 4S00A 2V6CA 4QR8A 4IKUA 5CLSA 1Y1NA 4ZWPA 1O0XA 2V3ZA 1BN5A 2GU7A 1R5HA 3PKBA 4EGEA 2ADUA 3IU8A 3BIPA 2Q94A 2GU4A 2HOWA 1YW8A 1WKMA 3CB6A 5JHUA 2Q93A 1YVMA 2B3KA 4RGZ1 4U73A 3Q6DA 4FLJA 4U71A 2OAZA 1QXZA 4U6WA 2GGCA 3S6BA 1WN1A 1XGNA 1QXYA 3IU9A 4S01A 4ZWOA 5JI6A 1XGSA 2GG3A 2V3YA 1KQ9A 2GA2A 5CDLA 4IPAA 4IKSA 5D6EA 5CDEA 2BHAA 2BHCA 1WY2A 2EVMA 2GG2A 4U69A 2Q95A 4ZNGA 1WL9A 5CDVA 2BWSA 2GU6A 1B59A 1C21A 3IG4A 3BITA 4U70A 2P9AA 2OKNA 1QXWA 4IKTA 5JFRA 4FO8A 2BWUA 2GZ5A 2NQ6A 1XNZA 2BHDA 1C22A 2BN7A 1R5GA 2EVCA 5CE6A 1YJ3A 1KQ0A 3RVAA 2ZSGA 3CTZA 5CIKA 2Q92A 4ZWUA 3PKCA 4FLLA 5FCFA 2GG7A 1C23A 4FO7A 1YW7A 1PV9A 4OOKA 2MATA 2GG8A 2BWYA 1C27A 3D27A 4PNCA 2P99A 1R58A 2GGBA 4A6VA 4S2RP 3CB5A 4KM3A 2BWVA 4PV4A 2NQ7A 3MX6A 3PKEA 1YW9A 2BH3A 2DFIA 5CNXA 4FLKA 2B3HA 2BWWA 4FKCA 3FM3A 2GG5A 3MR1A 2Q8KA 4IF7A 1A16A 4U6ZA 1WBQA 1BOAA 4IU6A 4U6EA 1MATA 1C24A 2IW2A 4JUQA 1W7VA 2EA4A 2V3XA 3FMRA 4U76A 3RORA 1N51A 2BHBA 4U1BA 2EA2A 1W2MA 3PKAA 5D6FA 1QZYA 3L7GA 2BWXA 4U6CA 2EVOA 3L24A 5FCHA 2GTXA 1KP0A 4FLIA 4HXXA 1CHMA 4IDYA 2BB7A 1M35A 2BWTA 3TAVA 1XGOA 4IECA 4A6WA 5E5BA 4B28A 4FUKA 3FMQA 4S2TP 1B6AA 1WL6A 1JAWA 3IU7A
chains in the Genus database with same CATH topology
4Z7MA 2P98A 2GG0A 4RZZA 1WLRA 2G6PA 2GU5A 2Q96A 3BIQA 3TB5A 4U75A 1XGMA 2GG9A 3MATA 4IKRA 4R60A 2B3LA 3PKDA 4RZYA 4MATA 4U6JA 4S00A 2V6CA 4QR8A 4IKUA 5CLSA 1Y1NA 4ZWPA 1O0XA 2V3ZA 1BN5A 2GU7A 1R5HA 3PKBA 4EGEA 2ADUA 3IU8A 3BIPA 2Q94A 2GU4A 2HOWA 1YW8A 1WKMA 3CB6A 5JHUA 2Q93A 1YVMA 2B3KA 4RGZ1 4U73A 3Q6DA 4FLJA 4U71A 2OAZA 1QXZA 4U6WA 2GGCA 3S6BA 1WN1A 1XGNA 1QXYA 3IU9A 4S01A 4ZWOA 5JI6A 1XGSA 2GG3A 2V3YA 1KQ9A 2GA2A 5CDLA 4IPAA 4IKSA 5D6EA 5CDEA 2BHAA 2BHCA 1WY2A 2EVMA 2GG2A 4U69A 2Q95A 4ZNGA 1WL9A 5CDVA 2BWSA 2GU6A 1B59A 1C21A 3IG4A 3BITA 4U70A 2P9AA 2OKNA 1QXWA 4IKTA 5JFRA 4FO8A 2BWUA 2GZ5A 2NQ6A 1XNZA 2BHDA 1C22A 2BN7A 1R5GA 2EVCA 5CE6A 1YJ3A 1KQ0A 3RVAA 2ZSGA 3CTZA 5CIKA 2Q92A 4ZWUA 3PKCA 4FLLA 5FCFA 2GG7A 1C23A 4FO7A 1YW7A 1PV9A 4OOKA 2MATA 2GG8A 2BWYA 1C27A 3D27A 4PNCA 2P99A 1R58A 2GGBA 4A6VA 4S2RP 3CB5A 4KM3A 2BWVA 4PV4A 2NQ7A 3MX6A 3PKEA 1YW9A 2BH3A 2DFIA 5CNXA 4FLKA 2B3HA 2BWWA 4FKCA 3FM3A 2GG5A 3MR1A 2Q8KA 4IF7A 1A16A 4U6ZA 1WBQA 1BOAA 4IU6A 4U6EA 1MATA 1C24A 2IW2A 4JUQA 1W7VA 2EA4A 2V3XA 3FMRA 4U76A 3RORA 1N51A 2BHBA 4U1BA 2EA2A 1W2MA 3PKAA 5D6FA 1QZYA 3L7GA 2BWXA 4U6CA 2EVOA 3L24A 5FCHA 2GTXA 1KP0A 4FLIA 4HXXA 1CHMA 4IDYA 2BB7A 1M35A 2BWTA 3TAVA 1XGOA 4IECA 4A6WA 5E5BA 4B28A 4FUKA 3FMQA 4S2TP 1B6AA 1WL6A 1JAWA 3IU7A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4Z7M A;  2P98 A;  2GG0 A;  4RZZ A;  1WLR A;  2G6P A;  2GU5 A;  2Q96 A;  3BIQ A;  3TB5 A;  4U75 A;  1XGM A;  2GG9 A;  3MAT A;  4IKR A;  4R60 A;  2B3L A;  3PKD A;  4RZY A;  4MAT A;  4U6J A;  4S00 A;  2V6C A;  4QR8 A;  4IKU A;  5CLS A;  1Y1N A;  4ZWP A;  1O0X A;  2V3Z A;  1BN5 A;  2GU7 A;  1R5H A;  3PKB A;  4EGE A;  2ADU A;  3IU8 A;  3BIP A;  2Q94 A;  2GU4 A;  2HOW A;  1YW8 A;  1WKM A;  3CB6 A;  5JHU A;  2Q93 A;  1YVM A;  2B3K A;  4RGZ 1;  4U73 A;  3Q6D A;  4FLJ A;  4U71 A;  2OAZ A;  1QXZ A;  4U6W A;  2GGC A;  3S6B A;  1WN1 A;  1XGN A;  1QXY A;  3IU9 A;  4S01 A;  4ZWO A;  5JI6 A;  1XGS A;  2GG3 A;  2V3Y A;  1KQ9 A;  2GA2 A;  5CDL A;  4IPA A;  4IKS A;  5D6E A;  5CDE A;  2BHA A;  2BHC A;  1WY2 A;  2EVM A;  2GG2 A;  4U69 A;  2Q95 A;  4ZNG A;  1WL9 A;  5CDV A;  2BWS A;  2GU6 A;  1B59 A;  1C21 A;  3IG4 A;  3BIT A;  4U70 A;  2P9A A;  2OKN A;  1QXW A;  4IKT A;  5JFR A;  4FO8 A;  2BWU A;  2GZ5 A;  2NQ6 A;  1XNZ A;  2BHD A;  1C22 A;  2BN7 A;  1R5G A;  2EVC A;  5CE6 A;  1YJ3 A;  1KQ0 A;  3RVA A;  2ZSG A;  3CTZ A;  5CIK A;  2Q92 A;  4ZWU A;  3PKC A;  4FLL A;  5FCF A;  2GG7 A;  1C23 A;  4FO7 A;  1YW7 A;  1PV9 A;  4OOK A;  2MAT A;  2GG8 A;  2BWY A;  1C27 A;  3D27 A;  4PNC A;  2P99 A;  1R58 A;  2GGB A;  4A6V A;  4S2R P;  3CB5 A;  4KM3 A;  2BWV A;  4PV4 A;  2NQ7 A;  3MX6 A;  3PKE A;  1YW9 A;  2BH3 A;  2DFI A;  5CNX A;  4FLK A;  2B3H A;  2BWW A;  4FKC A;  3FM3 A;  2GG5 A;  3MR1 A;  2Q8K A;  4IF7 A;  1A16 A;  4U6Z A;  1WBQ A;  1BOA A;  4IU6 A;  4U6E A;  1MAT A;  1C24 A;  2IW2 A;  4JUQ A;  1W7V A;  2EA4 A;  2V3X A;  3FMR A;  4U76 A;  3ROR A;  1N51 A;  2BHB A;  4U1B A;  2EA2 A;  1W2M A;  3PKA A;  5D6F A;  1QZY A;  3L7G A;  2BWX A;  4U6C A;  2EVO A;  3L24 A;  5FCH A;  2GTX A;  1KP0 A;  4FLI A;  4HXX A;  1CHM A;  4IDY A;  2BB7 A;  1M35 A;  2BWT A;  3TAV A;  1XGO A;  4IEC A;  4A6W A;  5E5B A;  4B28 A;  4FUK A;  3FMQ A;  4S2T P;  1B6A A;  1WL6 A;  1JAW A;  3IU7 A; 
#chains in the Genus database with same CATH topology
 4Z7M A;  2P98 A;  2GG0 A;  4RZZ A;  1WLR A;  2G6P A;  2GU5 A;  2Q96 A;  3BIQ A;  3TB5 A;  4U75 A;  1XGM A;  2GG9 A;  3MAT A;  4IKR A;  4R60 A;  2B3L A;  3PKD A;  4RZY A;  4MAT A;  4U6J A;  4S00 A;  2V6C A;  4QR8 A;  4IKU A;  5CLS A;  1Y1N A;  4ZWP A;  1O0X A;  2V3Z A;  1BN5 A;  2GU7 A;  1R5H A;  3PKB A;  4EGE A;  2ADU A;  3IU8 A;  3BIP A;  2Q94 A;  2GU4 A;  2HOW A;  1YW8 A;  1WKM A;  3CB6 A;  5JHU A;  2Q93 A;  1YVM A;  2B3K A;  4RGZ 1;  4U73 A;  3Q6D A;  4FLJ A;  4U71 A;  2OAZ A;  1QXZ A;  4U6W A;  2GGC A;  3S6B A;  1WN1 A;  1XGN A;  1QXY A;  3IU9 A;  4S01 A;  4ZWO A;  5JI6 A;  1XGS A;  2GG3 A;  2V3Y A;  1KQ9 A;  2GA2 A;  5CDL A;  4IPA A;  4IKS A;  5D6E A;  5CDE A;  2BHA A;  2BHC A;  1WY2 A;  2EVM A;  2GG2 A;  4U69 A;  2Q95 A;  4ZNG A;  1WL9 A;  5CDV A;  2BWS A;  2GU6 A;  1B59 A;  1C21 A;  3IG4 A;  3BIT A;  4U70 A;  2P9A A;  2OKN A;  1QXW A;  4IKT A;  5JFR A;  4FO8 A;  2BWU A;  2GZ5 A;  2NQ6 A;  1XNZ A;  2BHD A;  1C22 A;  2BN7 A;  1R5G A;  2EVC A;  5CE6 A;  1YJ3 A;  1KQ0 A;  3RVA A;  2ZSG A;  3CTZ A;  5CIK A;  2Q92 A;  4ZWU A;  3PKC A;  4FLL A;  5FCF A;  2GG7 A;  1C23 A;  4FO7 A;  1YW7 A;  1PV9 A;  4OOK A;  2MAT A;  2GG8 A;  2BWY A;  1C27 A;  3D27 A;  4PNC A;  2P99 A;  1R58 A;  2GGB A;  4A6V A;  4S2R P;  3CB5 A;  4KM3 A;  2BWV A;  4PV4 A;  2NQ7 A;  3MX6 A;  3PKE A;  1YW9 A;  2BH3 A;  2DFI A;  5CNX A;  4FLK A;  2B3H A;  2BWW A;  4FKC A;  3FM3 A;  2GG5 A;  3MR1 A;  2Q8K A;  4IF7 A;  1A16 A;  4U6Z A;  1WBQ A;  1BOA A;  4IU6 A;  4U6E A;  1MAT A;  1C24 A;  2IW2 A;  4JUQ A;  1W7V A;  2EA4 A;  2V3X A;  3FMR A;  4U76 A;  3ROR A;  1N51 A;  2BHB A;  4U1B A;  2EA2 A;  1W2M A;  3PKA A;  5D6F A;  1QZY A;  3L7G A;  2BWX A;  4U6C A;  2EVO A;  3L24 A;  5FCH A;  2GTX A;  1KP0 A;  4FLI A;  4HXX A;  1CHM A;  4IDY A;  2BB7 A;  1M35 A;  2BWT A;  3TAV A;  1XGO A;  4IEC A;  4A6W A;  5E5B A;  4B28 A;  4FUK A;  3FMQ A;  4S2T P;  1B6A A;  1WL6 A;  1JAW A;  3IU7 A; 
#chains in the Genus database with same CATH homology
 4Z7M A;  2P98 A;  2GG0 A;  4RZZ A;  1WLR A;  2G6P A;  2GU5 A;  2Q96 A;  3BIQ A;  3TB5 A;  4U75 A;  1XGM A;  2GG9 A;  3MAT A;  4IKR A;  4R60 A;  2B3L A;  3PKD A;  4RZY A;  4MAT A;  4U6J A;  4S00 A;  2V6C A;  4QR8 A;  4IKU A;  5CLS A;  1Y1N A;  4ZWP A;  1O0X A;  2V3Z A;  1BN5 A;  2GU7 A;  1R5H A;  3PKB A;  4EGE A;  2ADU A;  3IU8 A;  3BIP A;  2Q94 A;  2GU4 A;  2HOW A;  1YW8 A;  1WKM A;  3CB6 A;  5JHU A;  2Q93 A;  1YVM A;  2B3K A;  4RGZ 1;  4U73 A;  3Q6D A;  4FLJ A;  4U71 A;  2OAZ A;  1QXZ A;  4U6W A;  2GGC A;  3S6B A;  1WN1 A;  1XGN A;  1QXY A;  3IU9 A;  4S01 A;  4ZWO A;  5JI6 A;  1XGS A;  2GG3 A;  2V3Y A;  1KQ9 A;  2GA2 A;  5CDL A;  4IPA A;  4IKS A;  5D6E A;  5CDE A;  2BHA A;  2BHC A;  1WY2 A;  2EVM A;  2GG2 A;  4U69 A;  2Q95 A;  4ZNG A;  1WL9 A;  5CDV A;  2BWS A;  2GU6 A;  1B59 A;  1C21 A;  3IG4 A;  3BIT A;  4U70 A;  2P9A A;  2OKN A;  1QXW A;  4IKT A;  5JFR A;  4FO8 A;  2BWU A;  2GZ5 A;  2NQ6 A;  1XNZ A;  2BHD A;  1C22 A;  2BN7 A;  1R5G A;  2EVC A;  5CE6 A;  1YJ3 A;  1KQ0 A;  3RVA A;  2ZSG A;  3CTZ A;  5CIK A;  2Q92 A;  4ZWU A;  3PKC A;  4FLL A;  5FCF A;  2GG7 A;  1C23 A;  4FO7 A;  1YW7 A;  1PV9 A;  4OOK A;  2MAT A;  2GG8 A;  2BWY A;  1C27 A;  3D27 A;  4PNC A;  2P99 A;  1R58 A;  2GGB A;  4A6V A;  4S2R P;  3CB5 A;  4KM3 A;  2BWV A;  4PV4 A;  2NQ7 A;  3MX6 A;  3PKE A;  1YW9 A;  2BH3 A;  2DFI A;  5CNX A;  4FLK A;  2B3H A;  2BWW A;  4FKC A;  3FM3 A;  2GG5 A;  3MR1 A;  2Q8K A;  4IF7 A;  1A16 A;  4U6Z A;  1WBQ A;  1BOA A;  4IU6 A;  4U6E A;  1MAT A;  1C24 A;  2IW2 A;  4JUQ A;  1W7V A;  2EA4 A;  2V3X A;  3FMR A;  4U76 A;  3ROR A;  1N51 A;  2BHB A;  4U1B A;  2EA2 A;  1W2M A;  3PKA A;  5D6F A;  1QZY A;  3L7G A;  2BWX A;  4U6C A;  2EVO A;  3L24 A;  5FCH A;  2GTX A;  1KP0 A;  4FLI A;  4HXX A;  1CHM A;  4IDY A;  2BB7 A;  1M35 A;  2BWT A;  3TAV A;  1XGO A;  4IEC A;  4A6W A;  5E5B A;  4B28 A;  4FUK A;  3FMQ A;  4S2T P;  1B6A A;  1WL6 A;  1JAW A;  3IU7 A;
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite