2B3HA

Crystal structure of human methionine aminopeptidase type i with a third cobalt in the active site
Total Genus 103
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
103
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 103
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2b3hA00
3IG4A 5CDEA 2ADUA 4U6CA 2BWVA 2V3YA 2Q92A 1XGNA 5E5BA 1WL6A 4JUQA 5D6FA 4A6WA 4FO7A 4FUKA 1WN1A 1C27A 2GA2A 4U1BA 2GG8A 1B59A 4U75A 2DFIA 3S6BA 1KQ9A 4U70A 1YW8A 2IW2A 2BHAA 1W2MA 1YW7A 3MATA 3MR1A 4MATA 2ZSGA 4FKCA 1CHMA 4Z7MA 1QXYA 1QXZA 3IU9A 3PKEA 1BN5A 3PKBA 3CB5A 4U73A 2GG9A 4IPAA 4RZZA 1XGSA 2GU6A 2BWTA 4FLLA 1W7VA 2EVMA 4PNCA 4S2TP 1C24A 2Q93A 3BIPA 3TB5A 1XNZA 4ZWOA 2EA4A 1YVMA 1PV9A 5D6EA 1JAWA 4U76A 3MX6A 5CIKA 2OKNA 1N51A 1WKMA 3Q6DA 1KP0A 1C21A 5JHUA 2B3HA 3BIQA 2B3LA 3CB6A 1YJ3A 4IKRA 5FCHA 5CDLA 2Q96A 2BWYA 2BWUA 4PV4A 4U71A 3PKDA 3FM3A 2GG2A 4IKUA 4EGEA 4U6JA 1WBQA 4RGZ1 4S2RP 5JI6A 1KQ0A 4A6VA 4U69A 1M35A 1R5HA 1R58A 2GGCA 2P98A 2NQ7A 1R5GA 2GZ5A 4ZNGA 5CE6A 3L7GA 4IDYA 4FLIA 4IF7A 1A16A 3RORA 3IU7A 2EVCA 4IKTA 1QZYA 1XGMA 4HXXA 2GU7A 2G6PA 2GU4A 2NQ6A 4FO8A 2GU5A 4U6WA 1WLRA 5CDVA 2GG0A 4S01A 2BWSA 4FLKA 4IU6A 2OAZA 3PKAA 2V3XA 2BH3A 2V3ZA 3D27A 2Q94A 2BB7A 2BN7A 2EVOA 2BWXA 4B28A 4U6ZA 4ZWPA 2BHDA 1QXWA 1MATA 1WL9A 1YW9A 3FMRA 3PKCA 2EA2A 2P9AA 4KM3A 2Q95A 4ZWUA 1C23A 1O0XA 2BHBA 1B6AA 2Q8KA 4RZYA 2GG3A 3L24A 3IU8A 3RVAA 1C22A 2GG7A 2P99A 4IKSA 3CTZA 1Y1NA 2MATA 2GGBA 2GTXA 3FMQA 3BITA 4IECA 4FLJA 2GG5A 2B3KA 1WY2A 2HOWA 4OOKA 5JFRA 2BWWA 1XGOA 4QR8A 1BOAA 5CNXA 4S00A 2BHCA 5FCFA 5CLSA 4R60A 2V6CA 3TAVA 4U6EA
chains in the Genus database with same CATH superfamily
3IG4A 5CDEA 2ADUA 4U6CA 2BWVA 2V3YA 2Q92A 1XGNA 5E5BA 1WL6A 4JUQA 5D6FA 4A6WA 4FO7A 4FUKA 1WN1A 1C27A 2GA2A 4U1BA 2GG8A 1B59A 4U75A 2DFIA 3S6BA 1KQ9A 4U70A 1YW8A 2IW2A 2BHAA 1W2MA 1YW7A 3MATA 3MR1A 4MATA 2ZSGA 4FKCA 1CHMA 4Z7MA 1QXYA 1QXZA 3IU9A 3PKEA 1BN5A 3PKBA 3CB5A 4U73A 2GG9A 4IPAA 4RZZA 1XGSA 2GU6A 2BWTA 4FLLA 1W7VA 2EVMA 4PNCA 4S2TP 1C24A 2Q93A 3BIPA 3TB5A 1XNZA 4ZWOA 2EA4A 1YVMA 1PV9A 5D6EA 1JAWA 4U76A 3MX6A 5CIKA 2OKNA 1N51A 1WKMA 3Q6DA 1KP0A 1C21A 5JHUA 2B3HA 3BIQA 2B3LA 3CB6A 1YJ3A 4IKRA 5FCHA 5CDLA 2Q96A 2BWYA 2BWUA 4PV4A 4U71A 3PKDA 3FM3A 2GG2A 4IKUA 4EGEA 4U6JA 1WBQA 4RGZ1 4S2RP 5JI6A 1KQ0A 4A6VA 4U69A 1M35A 1R5HA 1R58A 2GGCA 2P98A 2NQ7A 1R5GA 2GZ5A 4ZNGA 5CE6A 3L7GA 4IDYA 4FLIA 4IF7A 1A16A 3RORA 3IU7A 2EVCA 4IKTA 1QZYA 1XGMA 4HXXA 2GU7A 2G6PA 2GU4A 2NQ6A 4FO8A 2GU5A 4U6WA 1WLRA 5CDVA 2GG0A 4S01A 2BWSA 4FLKA 4IU6A 2OAZA 3PKAA 2V3XA 2BH3A 2V3ZA 3D27A 2Q94A 2BB7A 2BN7A 2EVOA 2BWXA 4B28A 4U6ZA 4ZWPA 2BHDA 1QXWA 1MATA 1WL9A 1YW9A 3FMRA 3PKCA 2EA2A 2P9AA 4KM3A 2Q95A 4ZWUA 1C23A 1O0XA 2BHBA 1B6AA 2Q8KA 4RZYA 2GG3A 3L24A 3IU8A 3RVAA 1C22A 2GG7A 2P99A 4IKSA 3CTZA 1Y1NA 2MATA 2GGBA 2GTXA 3FMQA 3BITA 4IECA 4FLJA 2GG5A 2B3KA 1WY2A 2HOWA 4OOKA 5JFRA 2BWWA 1XGOA 4QR8A 1BOAA 5CNXA 4S00A 2BHCA 5FCFA 5CLSA 4R60A 2V6CA 3TAVA 4U6EA
chains in the Genus database with same CATH topology
3IG4A 5CDEA 2ADUA 4U6CA 2BWVA 2V3YA 2Q92A 1XGNA 5E5BA 1WL6A 4JUQA 5D6FA 4A6WA 4FO7A 4FUKA 1WN1A 1C27A 2GA2A 4U1BA 2GG8A 1B59A 4U75A 2DFIA 3S6BA 1KQ9A 4U70A 1YW8A 2IW2A 2BHAA 1W2MA 1YW7A 3MATA 3MR1A 4MATA 2ZSGA 4FKCA 1CHMA 4Z7MA 1QXYA 1QXZA 3IU9A 3PKEA 1BN5A 3PKBA 3CB5A 4U73A 2GG9A 4IPAA 4RZZA 1XGSA 2GU6A 2BWTA 4FLLA 1W7VA 2EVMA 4PNCA 4S2TP 1C24A 2Q93A 3BIPA 3TB5A 1XNZA 4ZWOA 2EA4A 1YVMA 1PV9A 5D6EA 1JAWA 4U76A 3MX6A 5CIKA 2OKNA 1N51A 1WKMA 3Q6DA 1KP0A 1C21A 5JHUA 2B3HA 3BIQA 2B3LA 3CB6A 1YJ3A 4IKRA 5FCHA 5CDLA 2Q96A 2BWYA 2BWUA 4PV4A 4U71A 3PKDA 3FM3A 2GG2A 4IKUA 4EGEA 4U6JA 1WBQA 4RGZ1 4S2RP 5JI6A 1KQ0A 4A6VA 4U69A 1M35A 1R5HA 1R58A 2GGCA 2P98A 2NQ7A 1R5GA 2GZ5A 4ZNGA 5CE6A 3L7GA 4IDYA 4FLIA 4IF7A 1A16A 3RORA 3IU7A 2EVCA 4IKTA 1QZYA 1XGMA 4HXXA 2GU7A 2G6PA 2GU4A 2NQ6A 4FO8A 2GU5A 4U6WA 1WLRA 5CDVA 2GG0A 4S01A 2BWSA 4FLKA 4IU6A 2OAZA 3PKAA 2V3XA 2BH3A 2V3ZA 3D27A 2Q94A 2BB7A 2BN7A 2EVOA 2BWXA 4B28A 4U6ZA 4ZWPA 2BHDA 1QXWA 1MATA 1WL9A 1YW9A 3FMRA 3PKCA 2EA2A 2P9AA 4KM3A 2Q95A 4ZWUA 1C23A 1O0XA 2BHBA 1B6AA 2Q8KA 4RZYA 2GG3A 3L24A 3IU8A 3RVAA 1C22A 2GG7A 2P99A 4IKSA 3CTZA 1Y1NA 2MATA 2GGBA 2GTXA 3FMQA 3BITA 4IECA 4FLJA 2GG5A 2B3KA 1WY2A 2HOWA 4OOKA 5JFRA 2BWWA 1XGOA 4QR8A 1BOAA 5CNXA 4S00A 2BHCA 5FCFA 5CLSA 4R60A 2V6CA 3TAVA 4U6EA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3IG4 A;  5CDE A;  2ADU A;  4U6C A;  2BWV A;  2V3Y A;  2Q92 A;  1XGN A;  5E5B A;  1WL6 A;  4JUQ A;  5D6F A;  4A6W A;  4FO7 A;  4FUK A;  1WN1 A;  1C27 A;  2GA2 A;  4U1B A;  2GG8 A;  1B59 A;  4U75 A;  2DFI A;  3S6B A;  1KQ9 A;  4U70 A;  1YW8 A;  2IW2 A;  2BHA A;  1W2M A;  1YW7 A;  3MAT A;  3MR1 A;  4MAT A;  2ZSG A;  4FKC A;  1CHM A;  4Z7M A;  1QXY A;  1QXZ A;  3IU9 A;  3PKE A;  1BN5 A;  3PKB A;  3CB5 A;  4U73 A;  2GG9 A;  4IPA A;  4RZZ A;  1XGS A;  2GU6 A;  2BWT A;  4FLL A;  1W7V A;  2EVM A;  4PNC A;  4S2T P;  1C24 A;  2Q93 A;  3BIP A;  3TB5 A;  1XNZ A;  4ZWO A;  2EA4 A;  1YVM A;  1PV9 A;  5D6E A;  1JAW A;  4U76 A;  3MX6 A;  5CIK A;  2OKN A;  1N51 A;  1WKM A;  3Q6D A;  1KP0 A;  1C21 A;  5JHU A;  2B3H A;  3BIQ A;  2B3L A;  3CB6 A;  1YJ3 A;  4IKR A;  5FCH A;  5CDL A;  2Q96 A;  2BWY A;  2BWU A;  4PV4 A;  4U71 A;  3PKD A;  3FM3 A;  2GG2 A;  4IKU A;  4EGE A;  4U6J A;  1WBQ A;  4RGZ 1;  4S2R P;  5JI6 A;  1KQ0 A;  4A6V A;  4U69 A;  1M35 A;  1R5H A;  1R58 A;  2GGC A;  2P98 A;  2NQ7 A;  1R5G A;  2GZ5 A;  4ZNG A;  5CE6 A;  3L7G A;  4IDY A;  4FLI A;  4IF7 A;  1A16 A;  3ROR A;  3IU7 A;  2EVC A;  4IKT A;  1QZY A;  1XGM A;  4HXX A;  2GU7 A;  2G6P A;  2GU4 A;  2NQ6 A;  4FO8 A;  2GU5 A;  4U6W A;  1WLR A;  5CDV A;  2GG0 A;  4S01 A;  2BWS A;  4FLK A;  4IU6 A;  2OAZ A;  3PKA A;  2V3X A;  2BH3 A;  2V3Z A;  3D27 A;  2Q94 A;  2BB7 A;  2BN7 A;  2EVO A;  2BWX A;  4B28 A;  4U6Z A;  4ZWP A;  2BHD A;  1QXW A;  1MAT A;  1WL9 A;  1YW9 A;  3FMR A;  3PKC A;  2EA2 A;  2P9A A;  4KM3 A;  2Q95 A;  4ZWU A;  1C23 A;  1O0X A;  2BHB A;  1B6A A;  2Q8K A;  4RZY A;  2GG3 A;  3L24 A;  3IU8 A;  3RVA A;  1C22 A;  2GG7 A;  2P99 A;  4IKS A;  3CTZ A;  1Y1N A;  2MAT A;  2GGB A;  2GTX A;  3FMQ A;  3BIT A;  4IEC A;  4FLJ A;  2GG5 A;  2B3K A;  1WY2 A;  2HOW A;  4OOK A;  5JFR A;  2BWW A;  1XGO A;  4QR8 A;  1BOA A;  5CNX A;  4S00 A;  2BHC A;  5FCF A;  5CLS A;  4R60 A;  2V6C A;  3TAV A;  4U6E A; 
#chains in the Genus database with same CATH topology
 3IG4 A;  5CDE A;  2ADU A;  4U6C A;  2BWV A;  2V3Y A;  2Q92 A;  1XGN A;  5E5B A;  1WL6 A;  4JUQ A;  5D6F A;  4A6W A;  4FO7 A;  4FUK A;  1WN1 A;  1C27 A;  2GA2 A;  4U1B A;  2GG8 A;  1B59 A;  4U75 A;  2DFI A;  3S6B A;  1KQ9 A;  4U70 A;  1YW8 A;  2IW2 A;  2BHA A;  1W2M A;  1YW7 A;  3MAT A;  3MR1 A;  4MAT A;  2ZSG A;  4FKC A;  1CHM A;  4Z7M A;  1QXY A;  1QXZ A;  3IU9 A;  3PKE A;  1BN5 A;  3PKB A;  3CB5 A;  4U73 A;  2GG9 A;  4IPA A;  4RZZ A;  1XGS A;  2GU6 A;  2BWT A;  4FLL A;  1W7V A;  2EVM A;  4PNC A;  4S2T P;  1C24 A;  2Q93 A;  3BIP A;  3TB5 A;  1XNZ A;  4ZWO A;  2EA4 A;  1YVM A;  1PV9 A;  5D6E A;  1JAW A;  4U76 A;  3MX6 A;  5CIK A;  2OKN A;  1N51 A;  1WKM A;  3Q6D A;  1KP0 A;  1C21 A;  5JHU A;  2B3H A;  3BIQ A;  2B3L A;  3CB6 A;  1YJ3 A;  4IKR A;  5FCH A;  5CDL A;  2Q96 A;  2BWY A;  2BWU A;  4PV4 A;  4U71 A;  3PKD A;  3FM3 A;  2GG2 A;  4IKU A;  4EGE A;  4U6J A;  1WBQ A;  4RGZ 1;  4S2R P;  5JI6 A;  1KQ0 A;  4A6V A;  4U69 A;  1M35 A;  1R5H A;  1R58 A;  2GGC A;  2P98 A;  2NQ7 A;  1R5G A;  2GZ5 A;  4ZNG A;  5CE6 A;  3L7G A;  4IDY A;  4FLI A;  4IF7 A;  1A16 A;  3ROR A;  3IU7 A;  2EVC A;  4IKT A;  1QZY A;  1XGM A;  4HXX A;  2GU7 A;  2G6P A;  2GU4 A;  2NQ6 A;  4FO8 A;  2GU5 A;  4U6W A;  1WLR A;  5CDV A;  2GG0 A;  4S01 A;  2BWS A;  4FLK A;  4IU6 A;  2OAZ A;  3PKA A;  2V3X A;  2BH3 A;  2V3Z A;  3D27 A;  2Q94 A;  2BB7 A;  2BN7 A;  2EVO A;  2BWX A;  4B28 A;  4U6Z A;  4ZWP A;  2BHD A;  1QXW A;  1MAT A;  1WL9 A;  1YW9 A;  3FMR A;  3PKC A;  2EA2 A;  2P9A A;  4KM3 A;  2Q95 A;  4ZWU A;  1C23 A;  1O0X A;  2BHB A;  1B6A A;  2Q8K A;  4RZY A;  2GG3 A;  3L24 A;  3IU8 A;  3RVA A;  1C22 A;  2GG7 A;  2P99 A;  4IKS A;  3CTZ A;  1Y1N A;  2MAT A;  2GGB A;  2GTX A;  3FMQ A;  3BIT A;  4IEC A;  4FLJ A;  2GG5 A;  2B3K A;  1WY2 A;  2HOW A;  4OOK A;  5JFR A;  2BWW A;  1XGO A;  4QR8 A;  1BOA A;  5CNX A;  4S00 A;  2BHC A;  5FCF A;  5CLS A;  4R60 A;  2V6C A;  3TAV A;  4U6E A; 
#chains in the Genus database with same CATH homology
 3IG4 A;  5CDE A;  2ADU A;  4U6C A;  2BWV A;  2V3Y A;  2Q92 A;  1XGN A;  5E5B A;  1WL6 A;  4JUQ A;  5D6F A;  4A6W A;  4FO7 A;  4FUK A;  1WN1 A;  1C27 A;  2GA2 A;  4U1B A;  2GG8 A;  1B59 A;  4U75 A;  2DFI A;  3S6B A;  1KQ9 A;  4U70 A;  1YW8 A;  2IW2 A;  2BHA A;  1W2M A;  1YW7 A;  3MAT A;  3MR1 A;  4MAT A;  2ZSG A;  4FKC A;  1CHM A;  4Z7M A;  1QXY A;  1QXZ A;  3IU9 A;  3PKE A;  1BN5 A;  3PKB A;  3CB5 A;  4U73 A;  2GG9 A;  4IPA A;  4RZZ A;  1XGS A;  2GU6 A;  2BWT A;  4FLL A;  1W7V A;  2EVM A;  4PNC A;  4S2T P;  1C24 A;  2Q93 A;  3BIP A;  3TB5 A;  1XNZ A;  4ZWO A;  2EA4 A;  1YVM A;  1PV9 A;  5D6E A;  1JAW A;  4U76 A;  3MX6 A;  5CIK A;  2OKN A;  1N51 A;  1WKM A;  3Q6D A;  1KP0 A;  1C21 A;  5JHU A;  2B3H A;  3BIQ A;  2B3L A;  3CB6 A;  1YJ3 A;  4IKR A;  5FCH A;  5CDL A;  2Q96 A;  2BWY A;  2BWU A;  4PV4 A;  4U71 A;  3PKD A;  3FM3 A;  2GG2 A;  4IKU A;  4EGE A;  4U6J A;  1WBQ A;  4RGZ 1;  4S2R P;  5JI6 A;  1KQ0 A;  4A6V A;  4U69 A;  1M35 A;  1R5H A;  1R58 A;  2GGC A;  2P98 A;  2NQ7 A;  1R5G A;  2GZ5 A;  4ZNG A;  5CE6 A;  3L7G A;  4IDY A;  4FLI A;  4IF7 A;  1A16 A;  3ROR A;  3IU7 A;  2EVC A;  4IKT A;  1QZY A;  1XGM A;  4HXX A;  2GU7 A;  2G6P A;  2GU4 A;  2NQ6 A;  4FO8 A;  2GU5 A;  4U6W A;  1WLR A;  5CDV A;  2GG0 A;  4S01 A;  2BWS A;  4FLK A;  4IU6 A;  2OAZ A;  3PKA A;  2V3X A;  2BH3 A;  2V3Z A;  3D27 A;  2Q94 A;  2BB7 A;  2BN7 A;  2EVO A;  2BWX A;  4B28 A;  4U6Z A;  4ZWP A;  2BHD A;  1QXW A;  1MAT A;  1WL9 A;  1YW9 A;  3FMR A;  3PKC A;  2EA2 A;  2P9A A;  4KM3 A;  2Q95 A;  4ZWU A;  1C23 A;  1O0X A;  2BHB A;  1B6A A;  2Q8K A;  4RZY A;  2GG3 A;  3L24 A;  3IU8 A;  3RVA A;  1C22 A;  2GG7 A;  2P99 A;  4IKS A;  3CTZ A;  1Y1N A;  2MAT A;  2GGB A;  2GTX A;  3FMQ A;  3BIT A;  4IEC A;  4FLJ A;  2GG5 A;  2B3K A;  1WY2 A;  2HOW A;  4OOK A;  5JFR A;  2BWW A;  1XGO A;  4QR8 A;  1BOA A;  5CNX A;  4S00 A;  2BHC A;  5FCF A;  5CLS A;  4R60 A;  2V6C A;  3TAV A;  4U6E A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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