4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
1BOAA 4IKTA 1B59A 1C27A 1BN5A 1MATA 4OOKA 5D6FA 5FCFA 3FMRA 2GG3A 1B6AA 2BWSA 4RGZ1 1YVMA 4HXXA 4ZWUA 4A6VA 3MATA 1KQ0A 4ZWOA 2BWXA 2GGCA 4U76A 3TB5A 2BHBA 3L24A 2BWTA 4U69A 2Q92A 2V6CA 5CIKA 4ZWPA 1KQ9A 1CHMA 3IU9A 2V3ZA 4FLIA 4IF7A 5CDVA 4IKSA 2BH3A 4IECA 1XGSA 1A16A 2BWUA 3MX6A 5CNXA 3MR1A 5E5BA 2BB7A 4Z7MA 4S2TP 1C23A 3BIQA 2P99A 2BWYA 1C21A 2G6PA 4QR8A 3TAVA 3D27A 3Q6DA 2MATA 4A6WA 1YW7A 2EVOA 1WN1A 1XGNA 4PNCA 4U6CA 1QZYA 3CTZA 1WY2A 2P98A 3BIPA 4IDYA 4U1BA 2DFIA 4IKRA 1KP0A 3IG4A 2B3KA 3PKBA 4FKCA 1R58A 2GG9A 3PKAA 4FLKA 2EA4A 2OAZA 4FO7A 2NQ7A 4IU6A 3BITA 2GU6A 3PKDA 1Y1NA 4JUQA 2GG2A 2BHCA 1WL9A 4U6WA 4S01A 1QXWA 3PKEA 3L7GA 1W7VA 3S6BA 2V3YA 1PV9A 2GGBA 5D6EA 1QXZA 2GU5A 2GZ5A 2BHAA 2OKNA 4U6ZA 1YW8A 2B3LA 2EA2A 4U71A 1WKMA 2GU4A 3PKCA 5JHUA 4U70A 4PV4A 4RZYA 2ZSGA 4RZZA 1JAWA 1WL6A 2GG5A 2GG7A 2P9AA 2V3XA 1QXYA 5FCHA 4ZNGA 3CB6A 2BWVA 2EVMA 3RORA 5CDEA 1C24A 2BHDA 3RVAA 5JI6A 1XNZA 4U75A 2BN7A 3IU8A 5CLSA 3FM3A 1R5HA 2Q94A 4R60A 2ADUA 2Q95A 1WLRA 1XGOA 5JFRA 2EVCA 2HOWA 2Q96A 3FMQA 1W2MA 4B28A 2GG8A 2BWWA 2GU7A 2NQ6A 2IW2A 1N51A 4FLJA 4IPAA 4KM3A 4EGEA 2GTXA 4FLLA 4U73A 1R5GA 2Q8KA 2GG0A 4FUKA 4MATA 4S00A 5CE6A 2GA2A 5CDLA 4U6EA 4FO8A 1M35A 1XGMA 1YJ3A 1C22A 1YW9A 2Q93A 3IU7A 4IKUA 1O0XA 4S2RP 4U6JA 3CB5A 1WBQA 2B3HA
chains in the Genus database with same CATH superfamily
1BOAA 4IKTA 1B59A 1C27A 1BN5A 1MATA 4OOKA 5D6FA 5FCFA 3FMRA 2GG3A 1B6AA 2BWSA 4RGZ1 1YVMA 4HXXA 4ZWUA 4A6VA 3MATA 1KQ0A 4ZWOA 2BWXA 2GGCA 4U76A 3TB5A 2BHBA 3L24A 2BWTA 4U69A 2Q92A 2V6CA 5CIKA 4ZWPA 1KQ9A 1CHMA 3IU9A 2V3ZA 4FLIA 4IF7A 5CDVA 4IKSA 2BH3A 4IECA 1XGSA 1A16A 2BWUA 3MX6A 5CNXA 3MR1A 5E5BA 2BB7A 4Z7MA 4S2TP 1C23A 3BIQA 2P99A 2BWYA 1C21A 2G6PA 4QR8A 3TAVA 3D27A 3Q6DA 2MATA 4A6WA 1YW7A 2EVOA 1WN1A 1XGNA 4PNCA 4U6CA 1QZYA 3CTZA 1WY2A 2P98A 3BIPA 4IDYA 4U1BA 2DFIA 4IKRA 1KP0A 3IG4A 2B3KA 3PKBA 4FKCA 1R58A 2GG9A 3PKAA 4FLKA 2EA4A 2OAZA 4FO7A 2NQ7A 4IU6A 3BITA 2GU6A 3PKDA 1Y1NA 4JUQA 2GG2A 2BHCA 1WL9A 4U6WA 4S01A 1QXWA 3PKEA 3L7GA 1W7VA 3S6BA 2V3YA 1PV9A 2GGBA 5D6EA 1QXZA 2GU5A 2GZ5A 2BHAA 2OKNA 4U6ZA 1YW8A 2B3LA 2EA2A 4U71A 1WKMA 2GU4A 3PKCA 5JHUA 4U70A 4PV4A 4RZYA 2ZSGA 4RZZA 1JAWA 1WL6A 2GG5A 2GG7A 2P9AA 2V3XA 1QXYA 5FCHA 4ZNGA 3CB6A 2BWVA 2EVMA 3RORA 5CDEA 1C24A 2BHDA 3RVAA 5JI6A 1XNZA 4U75A 2BN7A 3IU8A 5CLSA 3FM3A 1R5HA 2Q94A 4R60A 2ADUA 2Q95A 1WLRA 1XGOA 5JFRA 2EVCA 2HOWA 2Q96A 3FMQA 1W2MA 4B28A 2GG8A 2BWWA 2GU7A 2NQ6A 2IW2A 1N51A 4FLJA 4IPAA 4KM3A 4EGEA 2GTXA 4FLLA 4U73A 1R5GA 2Q8KA 2GG0A 4FUKA 4MATA 4S00A 5CE6A 2GA2A 5CDLA 4U6EA 4FO8A 1M35A 1XGMA 1YJ3A 1C22A 1YW9A 2Q93A 3IU7A 4IKUA 1O0XA 4S2RP 4U6JA 3CB5A 1WBQA 2B3HA
chains in the Genus database with same CATH topology
1BOAA 4IKTA 1B59A 1C27A 1BN5A 1MATA 4OOKA 5D6FA 5FCFA 3FMRA 2GG3A 1B6AA 2BWSA 4RGZ1 1YVMA 4HXXA 4ZWUA 4A6VA 3MATA 1KQ0A 4ZWOA 2BWXA 2GGCA 4U76A 3TB5A 2BHBA 3L24A 2BWTA 4U69A 2Q92A 2V6CA 5CIKA 4ZWPA 1KQ9A 1CHMA 3IU9A 2V3ZA 4FLIA 4IF7A 5CDVA 4IKSA 2BH3A 4IECA 1XGSA 1A16A 2BWUA 3MX6A 5CNXA 3MR1A 5E5BA 2BB7A 4Z7MA 4S2TP 1C23A 3BIQA 2P99A 2BWYA 1C21A 2G6PA 4QR8A 3TAVA 3D27A 3Q6DA 2MATA 4A6WA 1YW7A 2EVOA 1WN1A 1XGNA 4PNCA 4U6CA 1QZYA 3CTZA 1WY2A 2P98A 3BIPA 4IDYA 4U1BA 2DFIA 4IKRA 1KP0A 3IG4A 2B3KA 3PKBA 4FKCA 1R58A 2GG9A 3PKAA 4FLKA 2EA4A 2OAZA 4FO7A 2NQ7A 4IU6A 3BITA 2GU6A 3PKDA 1Y1NA 4JUQA 2GG2A 2BHCA 1WL9A 4U6WA 4S01A 1QXWA 3PKEA 3L7GA 1W7VA 3S6BA 2V3YA 1PV9A 2GGBA 5D6EA 1QXZA 2GU5A 2GZ5A 2BHAA 2OKNA 4U6ZA 1YW8A 2B3LA 2EA2A 4U71A 1WKMA 2GU4A 3PKCA 5JHUA 4U70A 4PV4A 4RZYA 2ZSGA 4RZZA 1JAWA 1WL6A 2GG5A 2GG7A 2P9AA 2V3XA 1QXYA 5FCHA 4ZNGA 3CB6A 2BWVA 2EVMA 3RORA 5CDEA 1C24A 2BHDA 3RVAA 5JI6A 1XNZA 4U75A 2BN7A 3IU8A 5CLSA 3FM3A 1R5HA 2Q94A 4R60A 2ADUA 2Q95A 1WLRA 1XGOA 5JFRA 2EVCA 2HOWA 2Q96A 3FMQA 1W2MA 4B28A 2GG8A 2BWWA 2GU7A 2NQ6A 2IW2A 1N51A 4FLJA 4IPAA 4KM3A 4EGEA 2GTXA 4FLLA 4U73A 1R5GA 2Q8KA 2GG0A 4FUKA 4MATA 4S00A 5CE6A 2GA2A 5CDLA 4U6EA 4FO8A 1M35A 1XGMA 1YJ3A 1C22A 1YW9A 2Q93A 3IU7A 4IKUA 1O0XA 4S2RP 4U6JA 3CB5A 1WBQA 2B3HA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1BOA A;  4IKT A;  1B59 A;  1C27 A;  1BN5 A;  1MAT A;  4OOK A;  5D6F A;  5FCF A;  3FMR A;  2GG3 A;  1B6A A;  2BWS A;  4RGZ 1;  1YVM A;  4HXX A;  4ZWU A;  4A6V A;  3MAT A;  1KQ0 A;  4ZWO A;  2BWX A;  2GGC A;  4U76 A;  3TB5 A;  2BHB A;  3L24 A;  2BWT A;  4U69 A;  2Q92 A;  2V6C A;  5CIK A;  4ZWP A;  1KQ9 A;  1CHM A;  3IU9 A;  2V3Z A;  4FLI A;  4IF7 A;  5CDV A;  4IKS A;  2BH3 A;  4IEC A;  1XGS A;  1A16 A;  2BWU A;  3MX6 A;  5CNX A;  3MR1 A;  5E5B A;  2BB7 A;  4Z7M A;  4S2T P;  1C23 A;  3BIQ A;  2P99 A;  2BWY A;  1C21 A;  2G6P A;  4QR8 A;  3TAV A;  3D27 A;  3Q6D A;  2MAT A;  4A6W A;  1YW7 A;  2EVO A;  1WN1 A;  1XGN A;  4PNC A;  4U6C A;  1QZY A;  3CTZ A;  1WY2 A;  2P98 A;  3BIP A;  4IDY A;  4U1B A;  2DFI A;  4IKR A;  1KP0 A;  3IG4 A;  2B3K A;  3PKB A;  4FKC A;  1R58 A;  2GG9 A;  3PKA A;  4FLK A;  2EA4 A;  2OAZ A;  4FO7 A;  2NQ7 A;  4IU6 A;  3BIT A;  2GU6 A;  3PKD A;  1Y1N A;  4JUQ A;  2GG2 A;  2BHC A;  1WL9 A;  4U6W A;  4S01 A;  1QXW A;  3PKE A;  3L7G A;  1W7V A;  3S6B A;  2V3Y A;  1PV9 A;  2GGB A;  5D6E A;  1QXZ A;  2GU5 A;  2GZ5 A;  2BHA A;  2OKN A;  4U6Z A;  1YW8 A;  2B3L A;  2EA2 A;  4U71 A;  1WKM A;  2GU4 A;  3PKC A;  5JHU A;  4U70 A;  4PV4 A;  4RZY A;  2ZSG A;  4RZZ A;  1JAW A;  1WL6 A;  2GG5 A;  2GG7 A;  2P9A A;  2V3X A;  1QXY A;  5FCH A;  4ZNG A;  3CB6 A;  2BWV A;  2EVM A;  3ROR A;  5CDE A;  1C24 A;  2BHD A;  3RVA A;  5JI6 A;  1XNZ A;  4U75 A;  2BN7 A;  3IU8 A;  5CLS A;  3FM3 A;  1R5H A;  2Q94 A;  4R60 A;  2ADU A;  2Q95 A;  1WLR A;  1XGO A;  5JFR A;  2EVC A;  2HOW A;  2Q96 A;  3FMQ A;  1W2M A;  4B28 A;  2GG8 A;  2BWW A;  2GU7 A;  2NQ6 A;  2IW2 A;  1N51 A;  4FLJ A;  4IPA A;  4KM3 A;  4EGE A;  2GTX A;  4FLL A;  4U73 A;  1R5G A;  2Q8K A;  2GG0 A;  4FUK A;  4MAT A;  4S00 A;  5CE6 A;  2GA2 A;  5CDL A;  4U6E A;  4FO8 A;  1M35 A;  1XGM A;  1YJ3 A;  1C22 A;  1YW9 A;  2Q93 A;  3IU7 A;  4IKU A;  1O0X A;  4S2R P;  4U6J A;  3CB5 A;  1WBQ A;  2B3H A; 
#chains in the Genus database with same CATH topology
 1BOA A;  4IKT A;  1B59 A;  1C27 A;  1BN5 A;  1MAT A;  4OOK A;  5D6F A;  5FCF A;  3FMR A;  2GG3 A;  1B6A A;  2BWS A;  4RGZ 1;  1YVM A;  4HXX A;  4ZWU A;  4A6V A;  3MAT A;  1KQ0 A;  4ZWO A;  2BWX A;  2GGC A;  4U76 A;  3TB5 A;  2BHB A;  3L24 A;  2BWT A;  4U69 A;  2Q92 A;  2V6C A;  5CIK A;  4ZWP A;  1KQ9 A;  1CHM A;  3IU9 A;  2V3Z A;  4FLI A;  4IF7 A;  5CDV A;  4IKS A;  2BH3 A;  4IEC A;  1XGS A;  1A16 A;  2BWU A;  3MX6 A;  5CNX A;  3MR1 A;  5E5B A;  2BB7 A;  4Z7M A;  4S2T P;  1C23 A;  3BIQ A;  2P99 A;  2BWY A;  1C21 A;  2G6P A;  4QR8 A;  3TAV A;  3D27 A;  3Q6D A;  2MAT A;  4A6W A;  1YW7 A;  2EVO A;  1WN1 A;  1XGN A;  4PNC A;  4U6C A;  1QZY A;  3CTZ A;  1WY2 A;  2P98 A;  3BIP A;  4IDY A;  4U1B A;  2DFI A;  4IKR A;  1KP0 A;  3IG4 A;  2B3K A;  3PKB A;  4FKC A;  1R58 A;  2GG9 A;  3PKA A;  4FLK A;  2EA4 A;  2OAZ A;  4FO7 A;  2NQ7 A;  4IU6 A;  3BIT A;  2GU6 A;  3PKD A;  1Y1N A;  4JUQ A;  2GG2 A;  2BHC A;  1WL9 A;  4U6W A;  4S01 A;  1QXW A;  3PKE A;  3L7G A;  1W7V A;  3S6B A;  2V3Y A;  1PV9 A;  2GGB A;  5D6E A;  1QXZ A;  2GU5 A;  2GZ5 A;  2BHA A;  2OKN A;  4U6Z A;  1YW8 A;  2B3L A;  2EA2 A;  4U71 A;  1WKM A;  2GU4 A;  3PKC A;  5JHU A;  4U70 A;  4PV4 A;  4RZY A;  2ZSG A;  4RZZ A;  1JAW A;  1WL6 A;  2GG5 A;  2GG7 A;  2P9A A;  2V3X A;  1QXY A;  5FCH A;  4ZNG A;  3CB6 A;  2BWV A;  2EVM A;  3ROR A;  5CDE A;  1C24 A;  2BHD A;  3RVA A;  5JI6 A;  1XNZ A;  4U75 A;  2BN7 A;  3IU8 A;  5CLS A;  3FM3 A;  1R5H A;  2Q94 A;  4R60 A;  2ADU A;  2Q95 A;  1WLR A;  1XGO A;  5JFR A;  2EVC A;  2HOW A;  2Q96 A;  3FMQ A;  1W2M A;  4B28 A;  2GG8 A;  2BWW A;  2GU7 A;  2NQ6 A;  2IW2 A;  1N51 A;  4FLJ A;  4IPA A;  4KM3 A;  4EGE A;  2GTX A;  4FLL A;  4U73 A;  1R5G A;  2Q8K A;  2GG0 A;  4FUK A;  4MAT A;  4S00 A;  5CE6 A;  2GA2 A;  5CDL A;  4U6E A;  4FO8 A;  1M35 A;  1XGM A;  1YJ3 A;  1C22 A;  1YW9 A;  2Q93 A;  3IU7 A;  4IKU A;  1O0X A;  4S2R P;  4U6J A;  3CB5 A;  1WBQ A;  2B3H A; 
#chains in the Genus database with same CATH homology
 1BOA A;  4IKT A;  1B59 A;  1C27 A;  1BN5 A;  1MAT A;  4OOK A;  5D6F A;  5FCF A;  3FMR A;  2GG3 A;  1B6A A;  2BWS A;  4RGZ 1;  1YVM A;  4HXX A;  4ZWU A;  4A6V A;  3MAT A;  1KQ0 A;  4ZWO A;  2BWX A;  2GGC A;  4U76 A;  3TB5 A;  2BHB A;  3L24 A;  2BWT A;  4U69 A;  2Q92 A;  2V6C A;  5CIK A;  4ZWP A;  1KQ9 A;  1CHM A;  3IU9 A;  2V3Z A;  4FLI A;  4IF7 A;  5CDV A;  4IKS A;  2BH3 A;  4IEC A;  1XGS A;  1A16 A;  2BWU A;  3MX6 A;  5CNX A;  3MR1 A;  5E5B A;  2BB7 A;  4Z7M A;  4S2T P;  1C23 A;  3BIQ A;  2P99 A;  2BWY A;  1C21 A;  2G6P A;  4QR8 A;  3TAV A;  3D27 A;  3Q6D A;  2MAT A;  4A6W A;  1YW7 A;  2EVO A;  1WN1 A;  1XGN A;  4PNC A;  4U6C A;  1QZY A;  3CTZ A;  1WY2 A;  2P98 A;  3BIP A;  4IDY A;  4U1B A;  2DFI A;  4IKR A;  1KP0 A;  3IG4 A;  2B3K A;  3PKB A;  4FKC A;  1R58 A;  2GG9 A;  3PKA A;  4FLK A;  2EA4 A;  2OAZ A;  4FO7 A;  2NQ7 A;  4IU6 A;  3BIT A;  2GU6 A;  3PKD A;  1Y1N A;  4JUQ A;  2GG2 A;  2BHC A;  1WL9 A;  4U6W A;  4S01 A;  1QXW A;  3PKE A;  3L7G A;  1W7V A;  3S6B A;  2V3Y A;  1PV9 A;  2GGB A;  5D6E A;  1QXZ A;  2GU5 A;  2GZ5 A;  2BHA A;  2OKN A;  4U6Z A;  1YW8 A;  2B3L A;  2EA2 A;  4U71 A;  1WKM A;  2GU4 A;  3PKC A;  5JHU A;  4U70 A;  4PV4 A;  4RZY A;  2ZSG A;  4RZZ A;  1JAW A;  1WL6 A;  2GG5 A;  2GG7 A;  2P9A A;  2V3X A;  1QXY A;  5FCH A;  4ZNG A;  3CB6 A;  2BWV A;  2EVM A;  3ROR A;  5CDE A;  1C24 A;  2BHD A;  3RVA A;  5JI6 A;  1XNZ A;  4U75 A;  2BN7 A;  3IU8 A;  5CLS A;  3FM3 A;  1R5H A;  2Q94 A;  4R60 A;  2ADU A;  2Q95 A;  1WLR A;  1XGO A;  5JFR A;  2EVC A;  2HOW A;  2Q96 A;  3FMQ A;  1W2M A;  4B28 A;  2GG8 A;  2BWW A;  2GU7 A;  2NQ6 A;  2IW2 A;  1N51 A;  4FLJ A;  4IPA A;  4KM3 A;  4EGE A;  2GTX A;  4FLL A;  4U73 A;  1R5G A;  2Q8K A;  2GG0 A;  4FUK A;  4MAT A;  4S00 A;  5CE6 A;  2GA2 A;  5CDL A;  4U6E A;  4FO8 A;  1M35 A;  1XGM A;  1YJ3 A;  1C22 A;  1YW9 A;  2Q93 A;  3IU7 A;  4IKU A;  1O0X A;  4S2R P;  4U6J A;  3CB5 A;  1WBQ A;  2B3H A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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