2P98A

E. coli methionine aminopeptidase monometalated with inhibitor ye7
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli
publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p98A00
1KQ0A 5CIKA 2B3HA 2OKNA 2NQ7A 1XGSA 2EVOA 1XGMA 1C24A 3BIPA 1YW8A 1MATA 3PKDA 1WL6A 2Q93A 1R5HA 4KM3A 2Q96A 3BIQA 5JHUA 1QXZA 2P9AA 4U73A 3IU9A 1C27A 1B6AA 2P99A 4IPAA 4QR8A 1BN5A 1JAWA 2GG9A 2GG8A 4U76A 4FO7A 4B28A 3MR1A 3TB5A 4U6ZA 5D6FA 4RZYA 2Q8KA 1W2MA 2BHBA 2DFIA 4FLIA 4U6WA 4U6JA 1WKMA 4U75A 4ZWPA 2GU4A 2BHAA 2BHCA 4IDYA 4S01A 2EVCA 4IECA 2B3LA 4FO8A 1XGNA 2BB7A 4U71A 1YW7A 3RVAA 4U70A 2GU7A 2EA4A 4OOKA 2BWTA 1QZYA 1C21A 4U6EA 4ZWUA 2Q94A 1BOAA 1KQ9A 4PNCA 2BWUA 4ZNGA 4IKRA 1O0XA 3PKCA 4RGZ1 1M35A 4A6WA 4MATA 1QXYA 3CB6A 4S2TP 2GTXA 2GG3A 2GG2A 4FLLA 4FKCA 2EVMA 2Q92A 3D27A 4PV4A 2GA2A 1CHMA 2OAZA 4U69A 3TAVA 2GGCA 2V3XA 3L7GA 4A6VA 5CDLA 2GG7A 2GGBA 4S00A 2EA2A 3BITA 3CB5A 1Y1NA 2HOWA 4U6CA 4Z7MA 2BWSA 2GZ5A 2BWVA 4S2RP 1XGOA 1A16A 1N51A 1C23A 5D6EA 1WBQA 3MATA 1PV9A 4HXXA 2GG5A 2P98A 4FUKA 1W7VA 1C22A 2GU6A 4JUQA 5JI6A 4IU6A 2BHDA 3IU7A 3FMQA 3FMRA 5FCFA 1KP0A 1WN1A 4IKTA 4ZWOA 2IW2A 5CE6A 3RORA 5FCHA 5JFRA 2V3YA 2V3ZA 2G6PA 1QXWA 3PKEA 4U1BA 3IU8A 2BWXA 2GU5A 3L24A 1WLRA 2BWWA 2ZSGA 2BH3A 2BWYA 2V6CA 3PKAA 1YVMA 4IF7A 1WY2A 1B59A 4IKSA 1R58A 1R5GA 3FM3A 1YW9A 3CTZA 5E5BA 2MATA 4FLKA 4IKUA 4EGEA 2ADUA 2GG0A 3MX6A 2B3KA 5CDEA 5CDVA 5CNXA 3Q6DA 1YJ3A 4RZZA 3PKBA 2Q95A 2NQ6A 4R60A 5CLSA 3S6BA 1WL9A 2BN7A 4FLJA 1XNZA 3IG4A
chains in the Genus database with same CATH superfamily
1KQ0A 5CIKA 2B3HA 2OKNA 2NQ7A 1XGSA 2EVOA 1XGMA 1C24A 3BIPA 1YW8A 1MATA 3PKDA 1WL6A 2Q93A 1R5HA 4KM3A 2Q96A 3BIQA 5JHUA 1QXZA 2P9AA 4U73A 3IU9A 1C27A 1B6AA 2P99A 4IPAA 4QR8A 1BN5A 1JAWA 2GG9A 2GG8A 4U76A 4FO7A 4B28A 3MR1A 3TB5A 4U6ZA 5D6FA 4RZYA 2Q8KA 1W2MA 2BHBA 2DFIA 4FLIA 4U6WA 4U6JA 1WKMA 4U75A 4ZWPA 2GU4A 2BHAA 2BHCA 4IDYA 4S01A 2EVCA 4IECA 2B3LA 4FO8A 1XGNA 2BB7A 4U71A 1YW7A 3RVAA 4U70A 2GU7A 2EA4A 4OOKA 2BWTA 1QZYA 1C21A 4U6EA 4ZWUA 2Q94A 1BOAA 1KQ9A 4PNCA 2BWUA 4ZNGA 4IKRA 1O0XA 3PKCA 4RGZ1 1M35A 4A6WA 4MATA 1QXYA 3CB6A 4S2TP 2GTXA 2GG3A 2GG2A 4FLLA 4FKCA 2EVMA 2Q92A 3D27A 4PV4A 2GA2A 1CHMA 2OAZA 4U69A 3TAVA 2GGCA 2V3XA 3L7GA 4A6VA 5CDLA 2GG7A 2GGBA 4S00A 2EA2A 3BITA 3CB5A 1Y1NA 2HOWA 4U6CA 4Z7MA 2BWSA 2GZ5A 2BWVA 4S2RP 1XGOA 1A16A 1N51A 1C23A 5D6EA 1WBQA 3MATA 1PV9A 4HXXA 2GG5A 2P98A 4FUKA 1W7VA 1C22A 2GU6A 4JUQA 5JI6A 4IU6A 2BHDA 3IU7A 3FMQA 3FMRA 5FCFA 1KP0A 1WN1A 4IKTA 4ZWOA 2IW2A 5CE6A 3RORA 5FCHA 5JFRA 2V3YA 2V3ZA 2G6PA 1QXWA 3PKEA 4U1BA 3IU8A 2BWXA 2GU5A 3L24A 1WLRA 2BWWA 2ZSGA 2BH3A 2BWYA 2V6CA 3PKAA 1YVMA 4IF7A 1WY2A 1B59A 4IKSA 1R58A 1R5GA 3FM3A 1YW9A 3CTZA 5E5BA 2MATA 4FLKA 4IKUA 4EGEA 2ADUA 2GG0A 3MX6A 2B3KA 5CDEA 5CDVA 5CNXA 3Q6DA 1YJ3A 4RZZA 3PKBA 2Q95A 2NQ6A 4R60A 5CLSA 3S6BA 1WL9A 2BN7A 4FLJA 1XNZA 3IG4A
chains in the Genus database with same CATH topology
1KQ0A 5CIKA 2B3HA 2OKNA 2NQ7A 1XGSA 2EVOA 1XGMA 1C24A 3BIPA 1YW8A 1MATA 3PKDA 1WL6A 2Q93A 1R5HA 4KM3A 2Q96A 3BIQA 5JHUA 1QXZA 2P9AA 4U73A 3IU9A 1C27A 1B6AA 2P99A 4IPAA 4QR8A 1BN5A 1JAWA 2GG9A 2GG8A 4U76A 4FO7A 4B28A 3MR1A 3TB5A 4U6ZA 5D6FA 4RZYA 2Q8KA 1W2MA 2BHBA 2DFIA 4FLIA 4U6WA 4U6JA 1WKMA 4U75A 4ZWPA 2GU4A 2BHAA 2BHCA 4IDYA 4S01A 2EVCA 4IECA 2B3LA 4FO8A 1XGNA 2BB7A 4U71A 1YW7A 3RVAA 4U70A 2GU7A 2EA4A 4OOKA 2BWTA 1QZYA 1C21A 4U6EA 4ZWUA 2Q94A 1BOAA 1KQ9A 4PNCA 2BWUA 4ZNGA 4IKRA 1O0XA 3PKCA 4RGZ1 1M35A 4A6WA 4MATA 1QXYA 3CB6A 4S2TP 2GTXA 2GG3A 2GG2A 4FLLA 4FKCA 2EVMA 2Q92A 3D27A 4PV4A 2GA2A 1CHMA 2OAZA 4U69A 3TAVA 2GGCA 2V3XA 3L7GA 4A6VA 5CDLA 2GG7A 2GGBA 4S00A 2EA2A 3BITA 3CB5A 1Y1NA 2HOWA 4U6CA 4Z7MA 2BWSA 2GZ5A 2BWVA 4S2RP 1XGOA 1A16A 1N51A 1C23A 5D6EA 1WBQA 3MATA 1PV9A 4HXXA 2GG5A 2P98A 4FUKA 1W7VA 1C22A 2GU6A 4JUQA 5JI6A 4IU6A 2BHDA 3IU7A 3FMQA 3FMRA 5FCFA 1KP0A 1WN1A 4IKTA 4ZWOA 2IW2A 5CE6A 3RORA 5FCHA 5JFRA 2V3YA 2V3ZA 2G6PA 1QXWA 3PKEA 4U1BA 3IU8A 2BWXA 2GU5A 3L24A 1WLRA 2BWWA 2ZSGA 2BH3A 2BWYA 2V6CA 3PKAA 1YVMA 4IF7A 1WY2A 1B59A 4IKSA 1R58A 1R5GA 3FM3A 1YW9A 3CTZA 5E5BA 2MATA 4FLKA 4IKUA 4EGEA 2ADUA 2GG0A 3MX6A 2B3KA 5CDEA 5CDVA 5CNXA 3Q6DA 1YJ3A 4RZZA 3PKBA 2Q95A 2NQ6A 4R60A 5CLSA 3S6BA 1WL9A 2BN7A 4FLJA 1XNZA 3IG4A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1KQ0 A;  5CIK A;  2B3H A;  2OKN A;  2NQ7 A;  1XGS A;  2EVO A;  1XGM A;  1C24 A;  3BIP A;  1YW8 A;  1MAT A;  3PKD A;  1WL6 A;  2Q93 A;  1R5H A;  4KM3 A;  2Q96 A;  3BIQ A;  5JHU A;  1QXZ A;  2P9A A;  4U73 A;  3IU9 A;  1C27 A;  1B6A A;  2P99 A;  4IPA A;  4QR8 A;  1BN5 A;  1JAW A;  2GG9 A;  2GG8 A;  4U76 A;  4FO7 A;  4B28 A;  3MR1 A;  3TB5 A;  4U6Z A;  5D6F A;  4RZY A;  2Q8K A;  1W2M A;  2BHB A;  2DFI A;  4FLI A;  4U6W A;  4U6J A;  1WKM A;  4U75 A;  4ZWP A;  2GU4 A;  2BHA A;  2BHC A;  4IDY A;  4S01 A;  2EVC A;  4IEC A;  2B3L A;  4FO8 A;  1XGN A;  2BB7 A;  4U71 A;  1YW7 A;  3RVA A;  4U70 A;  2GU7 A;  2EA4 A;  4OOK A;  2BWT A;  1QZY A;  1C21 A;  4U6E A;  4ZWU A;  2Q94 A;  1BOA A;  1KQ9 A;  4PNC A;  2BWU A;  4ZNG A;  4IKR A;  1O0X A;  3PKC A;  4RGZ 1;  1M35 A;  4A6W A;  4MAT A;  1QXY A;  3CB6 A;  4S2T P;  2GTX A;  2GG3 A;  2GG2 A;  4FLL A;  4FKC A;  2EVM A;  2Q92 A;  3D27 A;  4PV4 A;  2GA2 A;  1CHM A;  2OAZ A;  4U69 A;  3TAV A;  2GGC A;  2V3X A;  3L7G A;  4A6V A;  5CDL A;  2GG7 A;  2GGB A;  4S00 A;  2EA2 A;  3BIT A;  3CB5 A;  1Y1N A;  2HOW A;  4U6C A;  4Z7M A;  2BWS A;  2GZ5 A;  2BWV A;  4S2R P;  1XGO A;  1A16 A;  1N51 A;  1C23 A;  5D6E A;  1WBQ A;  3MAT A;  1PV9 A;  4HXX A;  2GG5 A;  2P98 A;  4FUK A;  1W7V A;  1C22 A;  2GU6 A;  4JUQ A;  5JI6 A;  4IU6 A;  2BHD A;  3IU7 A;  3FMQ A;  3FMR A;  5FCF A;  1KP0 A;  1WN1 A;  4IKT A;  4ZWO A;  2IW2 A;  5CE6 A;  3ROR A;  5FCH A;  5JFR A;  2V3Y A;  2V3Z A;  2G6P A;  1QXW A;  3PKE A;  4U1B A;  3IU8 A;  2BWX A;  2GU5 A;  3L24 A;  1WLR A;  2BWW A;  2ZSG A;  2BH3 A;  2BWY A;  2V6C A;  3PKA A;  1YVM A;  4IF7 A;  1WY2 A;  1B59 A;  4IKS A;  1R58 A;  1R5G A;  3FM3 A;  1YW9 A;  3CTZ A;  5E5B A;  2MAT A;  4FLK A;  4IKU A;  4EGE A;  2ADU A;  2GG0 A;  3MX6 A;  2B3K A;  5CDE A;  5CDV A;  5CNX A;  3Q6D A;  1YJ3 A;  4RZZ A;  3PKB A;  2Q95 A;  2NQ6 A;  4R60 A;  5CLS A;  3S6B A;  1WL9 A;  2BN7 A;  4FLJ A;  1XNZ A;  3IG4 A; 
#chains in the Genus database with same CATH topology
 1KQ0 A;  5CIK A;  2B3H A;  2OKN A;  2NQ7 A;  1XGS A;  2EVO A;  1XGM A;  1C24 A;  3BIP A;  1YW8 A;  1MAT A;  3PKD A;  1WL6 A;  2Q93 A;  1R5H A;  4KM3 A;  2Q96 A;  3BIQ A;  5JHU A;  1QXZ A;  2P9A A;  4U73 A;  3IU9 A;  1C27 A;  1B6A A;  2P99 A;  4IPA A;  4QR8 A;  1BN5 A;  1JAW A;  2GG9 A;  2GG8 A;  4U76 A;  4FO7 A;  4B28 A;  3MR1 A;  3TB5 A;  4U6Z A;  5D6F A;  4RZY A;  2Q8K A;  1W2M A;  2BHB A;  2DFI A;  4FLI A;  4U6W A;  4U6J A;  1WKM A;  4U75 A;  4ZWP A;  2GU4 A;  2BHA A;  2BHC A;  4IDY A;  4S01 A;  2EVC A;  4IEC A;  2B3L A;  4FO8 A;  1XGN A;  2BB7 A;  4U71 A;  1YW7 A;  3RVA A;  4U70 A;  2GU7 A;  2EA4 A;  4OOK A;  2BWT A;  1QZY A;  1C21 A;  4U6E A;  4ZWU A;  2Q94 A;  1BOA A;  1KQ9 A;  4PNC A;  2BWU A;  4ZNG A;  4IKR A;  1O0X A;  3PKC A;  4RGZ 1;  1M35 A;  4A6W A;  4MAT A;  1QXY A;  3CB6 A;  4S2T P;  2GTX A;  2GG3 A;  2GG2 A;  4FLL A;  4FKC A;  2EVM A;  2Q92 A;  3D27 A;  4PV4 A;  2GA2 A;  1CHM A;  2OAZ A;  4U69 A;  3TAV A;  2GGC A;  2V3X A;  3L7G A;  4A6V A;  5CDL A;  2GG7 A;  2GGB A;  4S00 A;  2EA2 A;  3BIT A;  3CB5 A;  1Y1N A;  2HOW A;  4U6C A;  4Z7M A;  2BWS A;  2GZ5 A;  2BWV A;  4S2R P;  1XGO A;  1A16 A;  1N51 A;  1C23 A;  5D6E A;  1WBQ A;  3MAT A;  1PV9 A;  4HXX A;  2GG5 A;  2P98 A;  4FUK A;  1W7V A;  1C22 A;  2GU6 A;  4JUQ A;  5JI6 A;  4IU6 A;  2BHD A;  3IU7 A;  3FMQ A;  3FMR A;  5FCF A;  1KP0 A;  1WN1 A;  4IKT A;  4ZWO A;  2IW2 A;  5CE6 A;  3ROR A;  5FCH A;  5JFR A;  2V3Y A;  2V3Z A;  2G6P A;  1QXW A;  3PKE A;  4U1B A;  3IU8 A;  2BWX A;  2GU5 A;  3L24 A;  1WLR A;  2BWW A;  2ZSG A;  2BH3 A;  2BWY A;  2V6C A;  3PKA A;  1YVM A;  4IF7 A;  1WY2 A;  1B59 A;  4IKS A;  1R58 A;  1R5G A;  3FM3 A;  1YW9 A;  3CTZ A;  5E5B A;  2MAT A;  4FLK A;  4IKU A;  4EGE A;  2ADU A;  2GG0 A;  3MX6 A;  2B3K A;  5CDE A;  5CDV A;  5CNX A;  3Q6D A;  1YJ3 A;  4RZZ A;  3PKB A;  2Q95 A;  2NQ6 A;  4R60 A;  5CLS A;  3S6B A;  1WL9 A;  2BN7 A;  4FLJ A;  1XNZ A;  3IG4 A; 
#chains in the Genus database with same CATH homology
 1KQ0 A;  5CIK A;  2B3H A;  2OKN A;  2NQ7 A;  1XGS A;  2EVO A;  1XGM A;  1C24 A;  3BIP A;  1YW8 A;  1MAT A;  3PKD A;  1WL6 A;  2Q93 A;  1R5H A;  4KM3 A;  2Q96 A;  3BIQ A;  5JHU A;  1QXZ A;  2P9A A;  4U73 A;  3IU9 A;  1C27 A;  1B6A A;  2P99 A;  4IPA A;  4QR8 A;  1BN5 A;  1JAW A;  2GG9 A;  2GG8 A;  4U76 A;  4FO7 A;  4B28 A;  3MR1 A;  3TB5 A;  4U6Z A;  5D6F A;  4RZY A;  2Q8K A;  1W2M A;  2BHB A;  2DFI A;  4FLI A;  4U6W A;  4U6J A;  1WKM A;  4U75 A;  4ZWP A;  2GU4 A;  2BHA A;  2BHC A;  4IDY A;  4S01 A;  2EVC A;  4IEC A;  2B3L A;  4FO8 A;  1XGN A;  2BB7 A;  4U71 A;  1YW7 A;  3RVA A;  4U70 A;  2GU7 A;  2EA4 A;  4OOK A;  2BWT A;  1QZY A;  1C21 A;  4U6E A;  4ZWU A;  2Q94 A;  1BOA A;  1KQ9 A;  4PNC A;  2BWU A;  4ZNG A;  4IKR A;  1O0X A;  3PKC A;  4RGZ 1;  1M35 A;  4A6W A;  4MAT A;  1QXY A;  3CB6 A;  4S2T P;  2GTX A;  2GG3 A;  2GG2 A;  4FLL A;  4FKC A;  2EVM A;  2Q92 A;  3D27 A;  4PV4 A;  2GA2 A;  1CHM A;  2OAZ A;  4U69 A;  3TAV A;  2GGC A;  2V3X A;  3L7G A;  4A6V A;  5CDL A;  2GG7 A;  2GGB A;  4S00 A;  2EA2 A;  3BIT A;  3CB5 A;  1Y1N A;  2HOW A;  4U6C A;  4Z7M A;  2BWS A;  2GZ5 A;  2BWV A;  4S2R P;  1XGO A;  1A16 A;  1N51 A;  1C23 A;  5D6E A;  1WBQ A;  3MAT A;  1PV9 A;  4HXX A;  2GG5 A;  2P98 A;  4FUK A;  1W7V A;  1C22 A;  2GU6 A;  4JUQ A;  5JI6 A;  4IU6 A;  2BHD A;  3IU7 A;  3FMQ A;  3FMR A;  5FCF A;  1KP0 A;  1WN1 A;  4IKT A;  4ZWO A;  2IW2 A;  5CE6 A;  3ROR A;  5FCH A;  5JFR A;  2V3Y A;  2V3Z A;  2G6P A;  1QXW A;  3PKE A;  4U1B A;  3IU8 A;  2BWX A;  2GU5 A;  3L24 A;  1WLR A;  2BWW A;  2ZSG A;  2BH3 A;  2BWY A;  2V6C A;  3PKA A;  1YVM A;  4IF7 A;  1WY2 A;  1B59 A;  4IKS A;  1R58 A;  1R5G A;  3FM3 A;  1YW9 A;  3CTZ A;  5E5B A;  2MAT A;  4FLK A;  4IKU A;  4EGE A;  2ADU A;  2GG0 A;  3MX6 A;  2B3K A;  5CDE A;  5CDV A;  5CNX A;  3Q6D A;  1YJ3 A;  4RZZ A;  3PKB A;  2Q95 A;  2NQ6 A;  4R60 A;  5CLS A;  3S6B A;  1WL9 A;  2BN7 A;  4FLJ A;  1XNZ A;  3IG4 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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