1WY2A

Crystal structure of the prolidase from pyrococcus horikoshii ot3
Total Genus 126
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
126
sequence length
351
structure length
351
Chain Sequence
MDIMNEKVKKIIEFMDKNSIDAVLIAKNPNVYYISGASPLAGGYILITGESATLYVPELEYEMAKEESNIPVEKFKKMDEFYKALEGIKSLGIESSLPYGFIEELKKKANIKEFKKVDDVIRDMRIIKSEKEIKIIEKACEIADKAVMAAIEEITEGKKEREVAAKVEYLMKMNGAEKPAFDTIIASGYRSALPHGVASDKRIERGDLVVIDLGALYQHYNSDITRTIVVGSPNEKQKEIYEIVLEAQKKAVESAKPGITAKELDSIARNIIAEYGYGEYFNHSLGHGVGLEVHEWPRVSQYDETVLREGMVITIEPGIYIPKIGGVRIEDTILITKNGSKRLTKTERELI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of the Prolidase from Pyrococcus horikoshii OT3
rcsb
source organism Pyrococcus horikoshii
molecule tags Hydrolase
molecule keywords Xaa-Pro dipeptidase
total genus 126
structure length 351
sequence length 351
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2005-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF01321 Creatinase_N Creatinase/Prolidase N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 1wy2A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1wy2A02
3CTZA 2Q8KA 1W2MA 2P99A 2EVCA 4FLJA 1KQ9A 4U6EA 3RVAA 2Q92A 5JHUA 1WL6A 2BWSA 3BITA 1QZYA 3BIQA 2Q95A 4FO7A 1WN1A 5D6FA 2P9AA 4A6VA 1XGSA 3PKCA 2BN7A 3PKEA 1C27A 2GU7A 1MATA 3PEBA 2BB7A 4JUQA 2EVMA 3OOOA 2BHAA 2IW2A 1QXZA 4R60A 4S00A 2GG3A 4IF7A 3FMQA 2BWWA 3PKDA 4FLIA 4EGEA 1R5HA 5D6EA 2GGBA 3IU7A 3MX6A 4ZWOA 4IKTA 1WLRA 3CB6A 3TB5A 3PN9A 4ZWUA 1QXYA 4Z7MA 5CDLA 3S6BA 1WBQA 2GG0A 4IECA 1XGNA 4U6WA 2GZ5A 4IKSA 1XGOA 3CB5A 1WL9A 3FMRA 4B28A 4U6JA 1Y1NA 2GG5A 4ZWPA 2GTXA 4U73A 2ADUA 2B3KA 1B6AA 2EA4A 4U70A 2GG2A 3BIPA 2BWUA 4FLLA 3IU8A 1R58A 2V3ZA 2GG7A 2BWYA 4U6ZA 4RZYA 1A16A 2GU4A 4IKUA 1BOAA 2GU6A 4HXXA 1BN5A 5E5BA 3L7GA 4U6CA 2OKNA 2EA2A 4IPAA 1M35A 2HOWA 4S2RP 2BH3A 4A6WA 5JI6A 2BHBA 3TAVA 5E2CA 1B59A 2G6PA 5JFRA 1XGMA 5FCFA 4U75A 4S01A 4IKRA 3L24A 5CDVA 3FM3A 4IU6A 2B3HA 4S2TP 4PV4A 2Q93A 2Q96A 3RORA 1C22A 3IU9A 2BWXA 2GG9A 2OAZA 1N51A 2GG8A 2ZSGA 4RGZ1 5FCHA 4U76A 3IG4A 3PKBA 2BHDA 4PNCA 1KQ0A 2EVOA 2P98A 5CLSA 1R5GA 4FUKA 3OVKA 1PV9A 1YJ3A 1CHMA 1W7VA 2V3YA 4ZNGA 2B3LA 1C21A 4QR8A 4U69A 2GU5A 4U1BA 5CIKA 1YVMA 1JAWA 2V3XA 1YW9A 2BWVA 4FKCA 3D27A 4FLKA 4FO8A 1KP0A 3QOCA 4IDYA 1WKMA 5CNXA 2MATA 4MATA 5CE6A 5CDEA 2BHCA 1YW8A 1C23A 2GGCA 2GA2A 3PKAA 4U71A 2Q94A 1O0XA 3MR1A 3O5VA 4RZZA 4KM3A 2NQ6A 2DFIA 3Q6DA 1WY2A 1XNZA 1YW7A 2BWTA 4OOKA 1QXWA 3IL0A 3MATA 1C24A 3I7MA 2V6CA 2NQ7A
chains in the Genus database with same CATH superfamily
3CTZA 2Q8KA 1W2MA 2P99A 2EVCA 4FLJA 1KQ9A 4U6EA 3RVAA 2Q92A 5JHUA 1WL6A 2BWSA 3BITA 1QZYA 3BIQA 2Q95A 4FO7A 1WN1A 5D6FA 2P9AA 4A6VA 1XGSA 3PKCA 2BN7A 3PKEA 1C27A 2GU7A 1MATA 3PEBA 2BB7A 4JUQA 2EVMA 3OOOA 2BHAA 2IW2A 1QXZA 4R60A 4S00A 2GG3A 4IF7A 3FMQA 2BWWA 3PKDA 4FLIA 4EGEA 1R5HA 5D6EA 2GGBA 3IU7A 3MX6A 4ZWOA 4IKTA 1WLRA 3CB6A 3TB5A 3PN9A 4ZWUA 1QXYA 4Z7MA 5CDLA 3S6BA 1WBQA 2GG0A 4IECA 1XGNA 4U6WA 2GZ5A 4IKSA 1XGOA 3CB5A 1WL9A 3FMRA 4B28A 4U6JA 1Y1NA 2GG5A 4ZWPA 2GTXA 4U73A 2ADUA 2B3KA 1B6AA 2EA4A 4U70A 2GG2A 3BIPA 2BWUA 4FLLA 3IU8A 1R58A 2V3ZA 2GG7A 2BWYA 4U6ZA 4RZYA 1A16A 2GU4A 4IKUA 1BOAA 2GU6A 4HXXA 1BN5A 5E5BA 3L7GA 4U6CA 2OKNA 2EA2A 4IPAA 1M35A 2HOWA 4S2RP 2BH3A 4A6WA 5JI6A 2BHBA 3TAVA 5E2CA 1B59A 2G6PA 5JFRA 1XGMA 5FCFA 4U75A 4S01A 4IKRA 3L24A 5CDVA 3FM3A 4IU6A 2B3HA 4S2TP 4PV4A 2Q93A 2Q96A 3RORA 1C22A 3IU9A 2BWXA 2GG9A 2OAZA 1N51A 2GG8A 2ZSGA 4RGZ1 5FCHA 4U76A 3IG4A 3PKBA 2BHDA 4PNCA 1KQ0A 2EVOA 2P98A 5CLSA 1R5GA 4FUKA 3OVKA 1PV9A 1YJ3A 1CHMA 1W7VA 2V3YA 4ZNGA 2B3LA 1C21A 4QR8A 4U69A 2GU5A 4U1BA 5CIKA 1YVMA 1JAWA 2V3XA 1YW9A 2BWVA 4FKCA 3D27A 4FLKA 4FO8A 1KP0A 3QOCA 4IDYA 1WKMA 5CNXA 2MATA 4MATA 5CE6A 5CDEA 2BHCA 1YW8A 1C23A 2GGCA 2GA2A 3PKAA 4U71A 2Q94A 1O0XA 3MR1A 3O5VA 4RZZA 4KM3A 2NQ6A 2DFIA 3Q6DA 1WY2A 1XNZA 1YW7A 2BWTA 4OOKA 1QXWA 3IL0A 3MATA 1C24A 3I7MA 2V6CA 2NQ7A
chains in the Genus database with same CATH topology
3CTZA 2Q8KA 1W2MA 2P99A 2EVCA 4FLJA 1KQ9A 4U6EA 3RVAA 2Q92A 5JHUA 1WL6A 2BWSA 3BITA 1QZYA 3BIQA 2Q95A 4FO7A 1WN1A 5D6FA 2P9AA 4A6VA 1XGSA 3PKCA 2BN7A 3PKEA 1C27A 2GU7A 1MATA 3PEBA 2BB7A 4JUQA 2EVMA 3OOOA 2BHAA 2IW2A 1QXZA 4R60A 4S00A 2GG3A 4IF7A 3FMQA 2BWWA 3PKDA 4FLIA 4EGEA 1R5HA 5D6EA 2GGBA 3IU7A 3MX6A 4ZWOA 4IKTA 1WLRA 3CB6A 3TB5A 3PN9A 4ZWUA 1QXYA 4Z7MA 5CDLA 3S6BA 1WBQA 2GG0A 4IECA 1XGNA 4U6WA 2GZ5A 4IKSA 1XGOA 3CB5A 1WL9A 3FMRA 4B28A 4U6JA 1Y1NA 2GG5A 4ZWPA 2GTXA 4U73A 2ADUA 2B3KA 1B6AA 2EA4A 4U70A 2GG2A 3BIPA 2BWUA 4FLLA 3IU8A 1R58A 2V3ZA 2GG7A 2BWYA 4U6ZA 4RZYA 1A16A 2GU4A 4IKUA 1BOAA 2GU6A 4HXXA 1BN5A 5E5BA 3L7GA 4U6CA 2OKNA 2EA2A 4IPAA 1M35A 2HOWA 4S2RP 2BH3A 4A6WA 5JI6A 2BHBA 3TAVA 5E2CA 1B59A 2G6PA 5JFRA 1XGMA 5FCFA 4U75A 4S01A 4IKRA 3L24A 5CDVA 3FM3A 4IU6A 2B3HA 4S2TP 4PV4A 2Q93A 2Q96A 3RORA 1C22A 3IU9A 2BWXA 2GG9A 2OAZA 1N51A 2GG8A 2ZSGA 4RGZ1 5FCHA 4U76A 3IG4A 3PKBA 2BHDA 4PNCA 1KQ0A 2EVOA 2P98A 5CLSA 1R5GA 4FUKA 3OVKA 1PV9A 1YJ3A 1CHMA 1W7VA 2V3YA 4ZNGA 2B3LA 1C21A 4QR8A 4U69A 2GU5A 4U1BA 5CIKA 1YVMA 1JAWA 2V3XA 1YW9A 2BWVA 4FKCA 3D27A 4FLKA 4FO8A 1KP0A 3QOCA 4IDYA 1WKMA 5CNXA 2MATA 4MATA 5CE6A 5CDEA 2BHCA 1YW8A 1C23A 2GGCA 2GA2A 3PKAA 4U71A 2Q94A 1O0XA 3MR1A 3O5VA 4RZZA 4KM3A 2NQ6A 2DFIA 3Q6DA 1WY2A 1XNZA 1YW7A 2BWTA 4OOKA 1QXWA 3IL0A 3MATA 1C24A 3I7MA 2V6CA 2NQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CTZ A;  2Q8K A;  1W2M A;  2P99 A;  2EVC A;  4FLJ A;  1KQ9 A;  4U6E A;  3RVA A;  2Q92 A;  5JHU A;  1WL6 A;  2BWS A;  3BIT A;  1QZY A;  3BIQ A;  2Q95 A;  4FO7 A;  1WN1 A;  5D6F A;  2P9A A;  4A6V A;  1XGS A;  3PKC A;  2BN7 A;  3PKE A;  1C27 A;  2GU7 A;  1MAT A;  3PEB A;  2BB7 A;  4JUQ A;  2EVM A;  3OOO A;  2BHA A;  2IW2 A;  1QXZ A;  4R60 A;  4S00 A;  2GG3 A;  4IF7 A;  3FMQ A;  2BWW A;  3PKD A;  4FLI A;  4EGE A;  1R5H A;  5D6E A;  2GGB A;  3IU7 A;  3MX6 A;  4ZWO A;  4IKT A;  1WLR A;  3CB6 A;  3TB5 A;  3PN9 A;  4ZWU A;  1QXY A;  4Z7M A;  5CDL A;  3S6B A;  1WBQ A;  2GG0 A;  4IEC A;  1XGN A;  4U6W A;  2GZ5 A;  4IKS A;  1XGO A;  3CB5 A;  1WL9 A;  3FMR A;  4B28 A;  4U6J A;  1Y1N A;  2GG5 A;  4ZWP A;  2GTX A;  4U73 A;  2ADU A;  2B3K A;  1B6A A;  2EA4 A;  4U70 A;  2GG2 A;  3BIP A;  2BWU A;  4FLL A;  3IU8 A;  1R58 A;  2V3Z A;  2GG7 A;  2BWY A;  4U6Z A;  4RZY A;  1A16 A;  2GU4 A;  4IKU A;  1BOA A;  2GU6 A;  4HXX A;  1BN5 A;  5E5B A;  3L7G A;  4U6C A;  2OKN A;  2EA2 A;  4IPA A;  1M35 A;  2HOW A;  4S2R P;  2BH3 A;  4A6W A;  5JI6 A;  2BHB A;  3TAV A;  5E2C A;  1B59 A;  2G6P A;  5JFR A;  1XGM A;  5FCF A;  4U75 A;  4S01 A;  4IKR A;  3L24 A;  5CDV A;  3FM3 A;  4IU6 A;  2B3H A;  4S2T P;  4PV4 A;  2Q93 A;  2Q96 A;  3ROR A;  1C22 A;  3IU9 A;  2BWX A;  2GG9 A;  2OAZ A;  1N51 A;  2GG8 A;  2ZSG A;  4RGZ 1;  5FCH A;  4U76 A;  3IG4 A;  3PKB A;  2BHD A;  4PNC A;  1KQ0 A;  2EVO A;  2P98 A;  5CLS A;  1R5G A;  4FUK A;  3OVK A;  1PV9 A;  1YJ3 A;  1CHM A;  1W7V A;  2V3Y A;  4ZNG A;  2B3L A;  1C21 A;  4QR8 A;  4U69 A;  2GU5 A;  4U1B A;  5CIK A;  1YVM A;  1JAW A;  2V3X A;  1YW9 A;  2BWV A;  4FKC A;  3D27 A;  4FLK A;  4FO8 A;  1KP0 A;  3QOC A;  4IDY A;  1WKM A;  5CNX A;  2MAT A;  4MAT A;  5CE6 A;  5CDE A;  2BHC A;  1YW8 A;  1C23 A;  2GGC A;  2GA2 A;  3PKA A;  4U71 A;  2Q94 A;  1O0X A;  3MR1 A;  3O5V A;  4RZZ A;  4KM3 A;  2NQ6 A;  2DFI A;  3Q6D A;  1WY2 A;  1XNZ A;  1YW7 A;  2BWT A;  4OOK A;  1QXW A;  3IL0 A;  3MAT A;  1C24 A;  3I7M A;  2V6C A;  2NQ7 A; 
#chains in the Genus database with same CATH topology
 3CTZ A;  2Q8K A;  1W2M A;  2P99 A;  2EVC A;  4FLJ A;  1KQ9 A;  4U6E A;  3RVA A;  2Q92 A;  5JHU A;  1WL6 A;  2BWS A;  3BIT A;  1QZY A;  3BIQ A;  2Q95 A;  4FO7 A;  1WN1 A;  5D6F A;  2P9A A;  4A6V A;  1XGS A;  3PKC A;  2BN7 A;  3PKE A;  1C27 A;  2GU7 A;  1MAT A;  3PEB A;  2BB7 A;  4JUQ A;  2EVM A;  3OOO A;  2BHA A;  2IW2 A;  1QXZ A;  4R60 A;  4S00 A;  2GG3 A;  4IF7 A;  3FMQ A;  2BWW A;  3PKD A;  4FLI A;  4EGE A;  1R5H A;  5D6E A;  2GGB A;  3IU7 A;  3MX6 A;  4ZWO A;  4IKT A;  1WLR A;  3CB6 A;  3TB5 A;  3PN9 A;  4ZWU A;  1QXY A;  4Z7M A;  5CDL A;  3S6B A;  1WBQ A;  2GG0 A;  4IEC A;  1XGN A;  4U6W A;  2GZ5 A;  4IKS A;  1XGO A;  3CB5 A;  1WL9 A;  3FMR A;  4B28 A;  4U6J A;  1Y1N A;  2GG5 A;  4ZWP A;  2GTX A;  4U73 A;  2ADU A;  2B3K A;  1B6A A;  2EA4 A;  4U70 A;  2GG2 A;  3BIP A;  2BWU A;  4FLL A;  3IU8 A;  1R58 A;  2V3Z A;  2GG7 A;  2BWY A;  4U6Z A;  4RZY A;  1A16 A;  2GU4 A;  4IKU A;  1BOA A;  2GU6 A;  4HXX A;  1BN5 A;  5E5B A;  3L7G A;  4U6C A;  2OKN A;  2EA2 A;  4IPA A;  1M35 A;  2HOW A;  4S2R P;  2BH3 A;  4A6W A;  5JI6 A;  2BHB A;  3TAV A;  5E2C A;  1B59 A;  2G6P A;  5JFR A;  1XGM A;  5FCF A;  4U75 A;  4S01 A;  4IKR A;  3L24 A;  5CDV A;  3FM3 A;  4IU6 A;  2B3H A;  4S2T P;  4PV4 A;  2Q93 A;  2Q96 A;  3ROR A;  1C22 A;  3IU9 A;  2BWX A;  2GG9 A;  2OAZ A;  1N51 A;  2GG8 A;  2ZSG A;  4RGZ 1;  5FCH A;  4U76 A;  3IG4 A;  3PKB A;  2BHD A;  4PNC A;  1KQ0 A;  2EVO A;  2P98 A;  5CLS A;  1R5G A;  4FUK A;  3OVK A;  1PV9 A;  1YJ3 A;  1CHM A;  1W7V A;  2V3Y A;  4ZNG A;  2B3L A;  1C21 A;  4QR8 A;  4U69 A;  2GU5 A;  4U1B A;  5CIK A;  1YVM A;  1JAW A;  2V3X A;  1YW9 A;  2BWV A;  4FKC A;  3D27 A;  4FLK A;  4FO8 A;  1KP0 A;  3QOC A;  4IDY A;  1WKM A;  5CNX A;  2MAT A;  4MAT A;  5CE6 A;  5CDE A;  2BHC A;  1YW8 A;  1C23 A;  2GGC A;  2GA2 A;  3PKA A;  4U71 A;  2Q94 A;  1O0X A;  3MR1 A;  3O5V A;  4RZZ A;  4KM3 A;  2NQ6 A;  2DFI A;  3Q6D A;  1WY2 A;  1XNZ A;  1YW7 A;  2BWT A;  4OOK A;  1QXW A;  3IL0 A;  3MAT A;  1C24 A;  3I7M A;  2V6C A;  2NQ7 A; 
#chains in the Genus database with same CATH homology
 3CTZ A;  2Q8K A;  1W2M A;  2P99 A;  2EVC A;  4FLJ A;  1KQ9 A;  4U6E A;  3RVA A;  2Q92 A;  5JHU A;  1WL6 A;  2BWS A;  3BIT A;  1QZY A;  3BIQ A;  2Q95 A;  4FO7 A;  1WN1 A;  5D6F A;  2P9A A;  4A6V A;  1XGS A;  3PKC A;  2BN7 A;  3PKE A;  1C27 A;  2GU7 A;  1MAT A;  3PEB A;  2BB7 A;  4JUQ A;  2EVM A;  3OOO A;  2BHA A;  2IW2 A;  1QXZ A;  4R60 A;  4S00 A;  2GG3 A;  4IF7 A;  3FMQ A;  2BWW A;  3PKD A;  4FLI A;  4EGE A;  1R5H A;  5D6E A;  2GGB A;  3IU7 A;  3MX6 A;  4ZWO A;  4IKT A;  1WLR A;  3CB6 A;  3TB5 A;  3PN9 A;  4ZWU A;  1QXY A;  4Z7M A;  5CDL A;  3S6B A;  1WBQ A;  2GG0 A;  4IEC A;  1XGN A;  4U6W A;  2GZ5 A;  4IKS A;  1XGO A;  3CB5 A;  1WL9 A;  3FMR A;  4B28 A;  4U6J A;  1Y1N A;  2GG5 A;  4ZWP A;  2GTX A;  4U73 A;  2ADU A;  2B3K A;  1B6A A;  2EA4 A;  4U70 A;  2GG2 A;  3BIP A;  2BWU A;  4FLL A;  3IU8 A;  1R58 A;  2V3Z A;  2GG7 A;  2BWY A;  4U6Z A;  4RZY A;  1A16 A;  2GU4 A;  4IKU A;  1BOA A;  2GU6 A;  4HXX A;  1BN5 A;  5E5B A;  3L7G A;  4U6C A;  2OKN A;  2EA2 A;  4IPA A;  1M35 A;  2HOW A;  4S2R P;  2BH3 A;  4A6W A;  5JI6 A;  2BHB A;  3TAV A;  5E2C A;  1B59 A;  2G6P A;  5JFR A;  1XGM A;  5FCF A;  4U75 A;  4S01 A;  4IKR A;  3L24 A;  5CDV A;  3FM3 A;  4IU6 A;  2B3H A;  4S2T P;  4PV4 A;  2Q93 A;  2Q96 A;  3ROR A;  1C22 A;  3IU9 A;  2BWX A;  2GG9 A;  2OAZ A;  1N51 A;  2GG8 A;  2ZSG A;  4RGZ 1;  5FCH A;  4U76 A;  3IG4 A;  3PKB A;  2BHD A;  4PNC A;  1KQ0 A;  2EVO A;  2P98 A;  5CLS A;  1R5G A;  4FUK A;  3OVK A;  1PV9 A;  1YJ3 A;  1CHM A;  1W7V A;  2V3Y A;  4ZNG A;  2B3L A;  1C21 A;  4QR8 A;  4U69 A;  2GU5 A;  4U1B A;  5CIK A;  1YVM A;  1JAW A;  2V3X A;  1YW9 A;  2BWV A;  4FKC A;  3D27 A;  4FLK A;  4FO8 A;  1KP0 A;  3QOC A;  4IDY A;  1WKM A;  5CNX A;  2MAT A;  4MAT A;  5CE6 A;  5CDE A;  2BHC A;  1YW8 A;  1C23 A;  2GGC A;  2GA2 A;  3PKA A;  4U71 A;  2Q94 A;  1O0X A;  3MR1 A;  3O5V A;  4RZZ A;  4KM3 A;  2NQ6 A;  2DFI A;  3Q6D A;  1WY2 A;  1XNZ A;  1YW7 A;  2BWT A;  4OOK A;  1QXW A;  3IL0 A;  3MAT A;  1C24 A;  3I7M A;  2V6C A;  2NQ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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