4KM3A

Discovery of a novel structural motif in methionine aminopeptidase from streptococci with possible post-translational modification
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
286
structure length
286
Chain Sequence
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a new genetic variant of methionine aminopeptidase from streptococci with possible post-translational modifications: biochemical and structural characterization.
pubmed doi rcsb
source organism Streptococcus pneumoniae
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
total genus 72
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4km3A00
4PV4A 2EA4A 4IKTA 2GG7A 4IKRA 2P98A 4RZZA 3IU8A 2GG2A 1KP0A 2V3XA 2BHCA 2BWTA 2GZ5A 1C21A 5CDVA 1B6AA 4U1BA 1W7VA 1YJ3A 2MATA 2ADUA 2P99A 1YVMA 5JI6A 1QXZA 4IKSA 1XNZA 4OOKA 5CIKA 2GGBA 2ZSGA 2Q93A 1QXYA 1QXWA 4B28A 4ZNGA 3PKDA 4RZYA 1W2MA 5D6EA 3RVAA 2GG0A 4ZWUA 2GU7A 3PKCA 1A16A 2BHAA 2EA2A 4U69A 2OAZA 1O0XA 4IDYA 1JAWA 1YW7A 2GG5A 5CNXA 1WN1A 2V3ZA 4R60A 3BITA 2G6PA 4HXXA 2Q8KA 4A6WA 1YW8A 1CHMA 2GGCA 3PKAA 4FLLA 3CTZA 4FLJA 4S01A 2GTXA 1KQ9A 1YW9A 4U6JA 3IU9A 4U70A 4S2RP 3S6BA 1WL6A 2OKNA 3MATA 2GU4A 1KQ0A 2BN7A 2DFIA 3L24A 2NQ7A 2GU6A 3MX6A 3Q6DA 1Y1NA 1C23A 2Q94A 4S2TP 4U6ZA 2BWXA 3D27A 2B3HA 1XGOA 1C24A 4U73A 2BWSA 3PKBA 2GG8A 2BWUA 4Z7MA 2BWYA 4JUQA 5FCHA 1MATA 4RGZ1 4ZWPA 1XGSA 4FO7A 4FKCA 1BN5A 3RORA 3FMQA 3PKEA 3TB5A 4A6VA 4IF7A 3IG4A 2IW2A 4U76A 4MATA 1C27A 4IKUA 2GG3A 4FUKA 1C22A 1N51A 1WY2A 4IPAA 5CE6A 1XGMA 3CB6A 2BWVA 1R5GA 3IU7A 1WBQA 4KM3A 1PV9A 5D6FA 4FLKA 2GU5A 4ZWOA 4U75A 2B3KA 1WL9A 5FCFA 2Q92A 4PNCA 4U6WA 4IU6A 2Q95A 3BIPA 2GA2A 4EGEA 1R5HA 2BWWA 4S00A 2Q96A 5CLSA 3CB5A 3TAVA 3BIQA 2V3YA 1WKMA 2BHBA 2P9AA 2V6CA 4IECA 1B59A 5JHUA 2EVCA 4U6EA 4U71A 2B3LA 2EVMA 1R58A 2BB7A 2NQ6A 1M35A 3L7GA 3MR1A 5E5BA 5CDLA 2HOWA 5CDEA 2BH3A 3FM3A 4QR8A 4U6CA 2GG9A 2BHDA 1BOAA 5JFRA 1WLRA 1XGNA 4FLIA 2EVOA 1QZYA 3FMRA 4FO8A
chains in the Genus database with same CATH superfamily
4PV4A 2EA4A 4IKTA 2GG7A 4IKRA 2P98A 4RZZA 3IU8A 2GG2A 1KP0A 2V3XA 2BHCA 2BWTA 2GZ5A 1C21A 5CDVA 1B6AA 4U1BA 1W7VA 1YJ3A 2MATA 2ADUA 2P99A 1YVMA 5JI6A 1QXZA 4IKSA 1XNZA 4OOKA 5CIKA 2GGBA 2ZSGA 2Q93A 1QXYA 1QXWA 4B28A 4ZNGA 3PKDA 4RZYA 1W2MA 5D6EA 3RVAA 2GG0A 4ZWUA 2GU7A 3PKCA 1A16A 2BHAA 2EA2A 4U69A 2OAZA 1O0XA 4IDYA 1JAWA 1YW7A 2GG5A 5CNXA 1WN1A 2V3ZA 4R60A 3BITA 2G6PA 4HXXA 2Q8KA 4A6WA 1YW8A 1CHMA 2GGCA 3PKAA 4FLLA 3CTZA 4FLJA 4S01A 2GTXA 1KQ9A 1YW9A 4U6JA 3IU9A 4U70A 4S2RP 3S6BA 1WL6A 2OKNA 3MATA 2GU4A 1KQ0A 2BN7A 2DFIA 3L24A 2NQ7A 2GU6A 3MX6A 3Q6DA 1Y1NA 1C23A 2Q94A 4S2TP 4U6ZA 2BWXA 3D27A 2B3HA 1XGOA 1C24A 4U73A 2BWSA 3PKBA 2GG8A 2BWUA 4Z7MA 2BWYA 4JUQA 5FCHA 1MATA 4RGZ1 4ZWPA 1XGSA 4FO7A 4FKCA 1BN5A 3RORA 3FMQA 3PKEA 3TB5A 4A6VA 4IF7A 3IG4A 2IW2A 4U76A 4MATA 1C27A 4IKUA 2GG3A 4FUKA 1C22A 1N51A 1WY2A 4IPAA 5CE6A 1XGMA 3CB6A 2BWVA 1R5GA 3IU7A 1WBQA 4KM3A 1PV9A 5D6FA 4FLKA 2GU5A 4ZWOA 4U75A 2B3KA 1WL9A 5FCFA 2Q92A 4PNCA 4U6WA 4IU6A 2Q95A 3BIPA 2GA2A 4EGEA 1R5HA 2BWWA 4S00A 2Q96A 5CLSA 3CB5A 3TAVA 3BIQA 2V3YA 1WKMA 2BHBA 2P9AA 2V6CA 4IECA 1B59A 5JHUA 2EVCA 4U6EA 4U71A 2B3LA 2EVMA 1R58A 2BB7A 2NQ6A 1M35A 3L7GA 3MR1A 5E5BA 5CDLA 2HOWA 5CDEA 2BH3A 3FM3A 4QR8A 4U6CA 2GG9A 2BHDA 1BOAA 5JFRA 1WLRA 1XGNA 4FLIA 2EVOA 1QZYA 3FMRA 4FO8A
chains in the Genus database with same CATH topology
4PV4A 2EA4A 4IKTA 2GG7A 4IKRA 2P98A 4RZZA 3IU8A 2GG2A 1KP0A 2V3XA 2BHCA 2BWTA 2GZ5A 1C21A 5CDVA 1B6AA 4U1BA 1W7VA 1YJ3A 2MATA 2ADUA 2P99A 1YVMA 5JI6A 1QXZA 4IKSA 1XNZA 4OOKA 5CIKA 2GGBA 2ZSGA 2Q93A 1QXYA 1QXWA 4B28A 4ZNGA 3PKDA 4RZYA 1W2MA 5D6EA 3RVAA 2GG0A 4ZWUA 2GU7A 3PKCA 1A16A 2BHAA 2EA2A 4U69A 2OAZA 1O0XA 4IDYA 1JAWA 1YW7A 2GG5A 5CNXA 1WN1A 2V3ZA 4R60A 3BITA 2G6PA 4HXXA 2Q8KA 4A6WA 1YW8A 1CHMA 2GGCA 3PKAA 4FLLA 3CTZA 4FLJA 4S01A 2GTXA 1KQ9A 1YW9A 4U6JA 3IU9A 4U70A 4S2RP 3S6BA 1WL6A 2OKNA 3MATA 2GU4A 1KQ0A 2BN7A 2DFIA 3L24A 2NQ7A 2GU6A 3MX6A 3Q6DA 1Y1NA 1C23A 2Q94A 4S2TP 4U6ZA 2BWXA 3D27A 2B3HA 1XGOA 1C24A 4U73A 2BWSA 3PKBA 2GG8A 2BWUA 4Z7MA 2BWYA 4JUQA 5FCHA 1MATA 4RGZ1 4ZWPA 1XGSA 4FO7A 4FKCA 1BN5A 3RORA 3FMQA 3PKEA 3TB5A 4A6VA 4IF7A 3IG4A 2IW2A 4U76A 4MATA 1C27A 4IKUA 2GG3A 4FUKA 1C22A 1N51A 1WY2A 4IPAA 5CE6A 1XGMA 3CB6A 2BWVA 1R5GA 3IU7A 1WBQA 4KM3A 1PV9A 5D6FA 4FLKA 2GU5A 4ZWOA 4U75A 2B3KA 1WL9A 5FCFA 2Q92A 4PNCA 4U6WA 4IU6A 2Q95A 3BIPA 2GA2A 4EGEA 1R5HA 2BWWA 4S00A 2Q96A 5CLSA 3CB5A 3TAVA 3BIQA 2V3YA 1WKMA 2BHBA 2P9AA 2V6CA 4IECA 1B59A 5JHUA 2EVCA 4U6EA 4U71A 2B3LA 2EVMA 1R58A 2BB7A 2NQ6A 1M35A 3L7GA 3MR1A 5E5BA 5CDLA 2HOWA 5CDEA 2BH3A 3FM3A 4QR8A 4U6CA 2GG9A 2BHDA 1BOAA 5JFRA 1WLRA 1XGNA 4FLIA 2EVOA 1QZYA 3FMRA 4FO8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PV4 A;  2EA4 A;  4IKT A;  2GG7 A;  4IKR A;  2P98 A;  4RZZ A;  3IU8 A;  2GG2 A;  1KP0 A;  2V3X A;  2BHC A;  2BWT A;  2GZ5 A;  1C21 A;  5CDV A;  1B6A A;  4U1B A;  1W7V A;  1YJ3 A;  2MAT A;  2ADU A;  2P99 A;  1YVM A;  5JI6 A;  1QXZ A;  4IKS A;  1XNZ A;  4OOK A;  5CIK A;  2GGB A;  2ZSG A;  2Q93 A;  1QXY A;  1QXW A;  4B28 A;  4ZNG A;  3PKD A;  4RZY A;  1W2M A;  5D6E A;  3RVA A;  2GG0 A;  4ZWU A;  2GU7 A;  3PKC A;  1A16 A;  2BHA A;  2EA2 A;  4U69 A;  2OAZ A;  1O0X A;  4IDY A;  1JAW A;  1YW7 A;  2GG5 A;  5CNX A;  1WN1 A;  2V3Z A;  4R60 A;  3BIT A;  2G6P A;  4HXX A;  2Q8K A;  4A6W A;  1YW8 A;  1CHM A;  2GGC A;  3PKA A;  4FLL A;  3CTZ A;  4FLJ A;  4S01 A;  2GTX A;  1KQ9 A;  1YW9 A;  4U6J A;  3IU9 A;  4U70 A;  4S2R P;  3S6B A;  1WL6 A;  2OKN A;  3MAT A;  2GU4 A;  1KQ0 A;  2BN7 A;  2DFI A;  3L24 A;  2NQ7 A;  2GU6 A;  3MX6 A;  3Q6D A;  1Y1N A;  1C23 A;  2Q94 A;  4S2T P;  4U6Z A;  2BWX A;  3D27 A;  2B3H A;  1XGO A;  1C24 A;  4U73 A;  2BWS A;  3PKB A;  2GG8 A;  2BWU A;  4Z7M A;  2BWY A;  4JUQ A;  5FCH A;  1MAT A;  4RGZ 1;  4ZWP A;  1XGS A;  4FO7 A;  4FKC A;  1BN5 A;  3ROR A;  3FMQ A;  3PKE A;  3TB5 A;  4A6V A;  4IF7 A;  3IG4 A;  2IW2 A;  4U76 A;  4MAT A;  1C27 A;  4IKU A;  2GG3 A;  4FUK A;  1C22 A;  1N51 A;  1WY2 A;  4IPA A;  5CE6 A;  1XGM A;  3CB6 A;  2BWV A;  1R5G A;  3IU7 A;  1WBQ A;  4KM3 A;  1PV9 A;  5D6F A;  4FLK A;  2GU5 A;  4ZWO A;  4U75 A;  2B3K A;  1WL9 A;  5FCF A;  2Q92 A;  4PNC A;  4U6W A;  4IU6 A;  2Q95 A;  3BIP A;  2GA2 A;  4EGE A;  1R5H A;  2BWW A;  4S00 A;  2Q96 A;  5CLS A;  3CB5 A;  3TAV A;  3BIQ A;  2V3Y A;  1WKM A;  2BHB A;  2P9A A;  2V6C A;  4IEC A;  1B59 A;  5JHU A;  2EVC A;  4U6E A;  4U71 A;  2B3L A;  2EVM A;  1R58 A;  2BB7 A;  2NQ6 A;  1M35 A;  3L7G A;  3MR1 A;  5E5B A;  5CDL A;  2HOW A;  5CDE A;  2BH3 A;  3FM3 A;  4QR8 A;  4U6C A;  2GG9 A;  2BHD A;  1BOA A;  5JFR A;  1WLR A;  1XGN A;  4FLI A;  2EVO A;  1QZY A;  3FMR A;  4FO8 A; 
#chains in the Genus database with same CATH topology
 4PV4 A;  2EA4 A;  4IKT A;  2GG7 A;  4IKR A;  2P98 A;  4RZZ A;  3IU8 A;  2GG2 A;  1KP0 A;  2V3X A;  2BHC A;  2BWT A;  2GZ5 A;  1C21 A;  5CDV A;  1B6A A;  4U1B A;  1W7V A;  1YJ3 A;  2MAT A;  2ADU A;  2P99 A;  1YVM A;  5JI6 A;  1QXZ A;  4IKS A;  1XNZ A;  4OOK A;  5CIK A;  2GGB A;  2ZSG A;  2Q93 A;  1QXY A;  1QXW A;  4B28 A;  4ZNG A;  3PKD A;  4RZY A;  1W2M A;  5D6E A;  3RVA A;  2GG0 A;  4ZWU A;  2GU7 A;  3PKC A;  1A16 A;  2BHA A;  2EA2 A;  4U69 A;  2OAZ A;  1O0X A;  4IDY A;  1JAW A;  1YW7 A;  2GG5 A;  5CNX A;  1WN1 A;  2V3Z A;  4R60 A;  3BIT A;  2G6P A;  4HXX A;  2Q8K A;  4A6W A;  1YW8 A;  1CHM A;  2GGC A;  3PKA A;  4FLL A;  3CTZ A;  4FLJ A;  4S01 A;  2GTX A;  1KQ9 A;  1YW9 A;  4U6J A;  3IU9 A;  4U70 A;  4S2R P;  3S6B A;  1WL6 A;  2OKN A;  3MAT A;  2GU4 A;  1KQ0 A;  2BN7 A;  2DFI A;  3L24 A;  2NQ7 A;  2GU6 A;  3MX6 A;  3Q6D A;  1Y1N A;  1C23 A;  2Q94 A;  4S2T P;  4U6Z A;  2BWX A;  3D27 A;  2B3H A;  1XGO A;  1C24 A;  4U73 A;  2BWS A;  3PKB A;  2GG8 A;  2BWU A;  4Z7M A;  2BWY A;  4JUQ A;  5FCH A;  1MAT A;  4RGZ 1;  4ZWP A;  1XGS A;  4FO7 A;  4FKC A;  1BN5 A;  3ROR A;  3FMQ A;  3PKE A;  3TB5 A;  4A6V A;  4IF7 A;  3IG4 A;  2IW2 A;  4U76 A;  4MAT A;  1C27 A;  4IKU A;  2GG3 A;  4FUK A;  1C22 A;  1N51 A;  1WY2 A;  4IPA A;  5CE6 A;  1XGM A;  3CB6 A;  2BWV A;  1R5G A;  3IU7 A;  1WBQ A;  4KM3 A;  1PV9 A;  5D6F A;  4FLK A;  2GU5 A;  4ZWO A;  4U75 A;  2B3K A;  1WL9 A;  5FCF A;  2Q92 A;  4PNC A;  4U6W A;  4IU6 A;  2Q95 A;  3BIP A;  2GA2 A;  4EGE A;  1R5H A;  2BWW A;  4S00 A;  2Q96 A;  5CLS A;  3CB5 A;  3TAV A;  3BIQ A;  2V3Y A;  1WKM A;  2BHB A;  2P9A A;  2V6C A;  4IEC A;  1B59 A;  5JHU A;  2EVC A;  4U6E A;  4U71 A;  2B3L A;  2EVM A;  1R58 A;  2BB7 A;  2NQ6 A;  1M35 A;  3L7G A;  3MR1 A;  5E5B A;  5CDL A;  2HOW A;  5CDE A;  2BH3 A;  3FM3 A;  4QR8 A;  4U6C A;  2GG9 A;  2BHD A;  1BOA A;  5JFR A;  1WLR A;  1XGN A;  4FLI A;  2EVO A;  1QZY A;  3FMR A;  4FO8 A; 
#chains in the Genus database with same CATH homology
 4PV4 A;  2EA4 A;  4IKT A;  2GG7 A;  4IKR A;  2P98 A;  4RZZ A;  3IU8 A;  2GG2 A;  1KP0 A;  2V3X A;  2BHC A;  2BWT A;  2GZ5 A;  1C21 A;  5CDV A;  1B6A A;  4U1B A;  1W7V A;  1YJ3 A;  2MAT A;  2ADU A;  2P99 A;  1YVM A;  5JI6 A;  1QXZ A;  4IKS A;  1XNZ A;  4OOK A;  5CIK A;  2GGB A;  2ZSG A;  2Q93 A;  1QXY A;  1QXW A;  4B28 A;  4ZNG A;  3PKD A;  4RZY A;  1W2M A;  5D6E A;  3RVA A;  2GG0 A;  4ZWU A;  2GU7 A;  3PKC A;  1A16 A;  2BHA A;  2EA2 A;  4U69 A;  2OAZ A;  1O0X A;  4IDY A;  1JAW A;  1YW7 A;  2GG5 A;  5CNX A;  1WN1 A;  2V3Z A;  4R60 A;  3BIT A;  2G6P A;  4HXX A;  2Q8K A;  4A6W A;  1YW8 A;  1CHM A;  2GGC A;  3PKA A;  4FLL A;  3CTZ A;  4FLJ A;  4S01 A;  2GTX A;  1KQ9 A;  1YW9 A;  4U6J A;  3IU9 A;  4U70 A;  4S2R P;  3S6B A;  1WL6 A;  2OKN A;  3MAT A;  2GU4 A;  1KQ0 A;  2BN7 A;  2DFI A;  3L24 A;  2NQ7 A;  2GU6 A;  3MX6 A;  3Q6D A;  1Y1N A;  1C23 A;  2Q94 A;  4S2T P;  4U6Z A;  2BWX A;  3D27 A;  2B3H A;  1XGO A;  1C24 A;  4U73 A;  2BWS A;  3PKB A;  2GG8 A;  2BWU A;  4Z7M A;  2BWY A;  4JUQ A;  5FCH A;  1MAT A;  4RGZ 1;  4ZWP A;  1XGS A;  4FO7 A;  4FKC A;  1BN5 A;  3ROR A;  3FMQ A;  3PKE A;  3TB5 A;  4A6V A;  4IF7 A;  3IG4 A;  2IW2 A;  4U76 A;  4MAT A;  1C27 A;  4IKU A;  2GG3 A;  4FUK A;  1C22 A;  1N51 A;  1WY2 A;  4IPA A;  5CE6 A;  1XGM A;  3CB6 A;  2BWV A;  1R5G A;  3IU7 A;  1WBQ A;  4KM3 A;  1PV9 A;  5D6F A;  4FLK A;  2GU5 A;  4ZWO A;  4U75 A;  2B3K A;  1WL9 A;  5FCF A;  2Q92 A;  4PNC A;  4U6W A;  4IU6 A;  2Q95 A;  3BIP A;  2GA2 A;  4EGE A;  1R5H A;  2BWW A;  4S00 A;  2Q96 A;  5CLS A;  3CB5 A;  3TAV A;  3BIQ A;  2V3Y A;  1WKM A;  2BHB A;  2P9A A;  2V6C A;  4IEC A;  1B59 A;  5JHU A;  2EVC A;  4U6E A;  4U71 A;  2B3L A;  2EVM A;  1R58 A;  2BB7 A;  2NQ6 A;  1M35 A;  3L7G A;  3MR1 A;  5E5B A;  5CDL A;  2HOW A;  5CDE A;  2BH3 A;  3FM3 A;  4QR8 A;  4U6C A;  2GG9 A;  2BHD A;  1BOA A;  5JFR A;  1WLR A;  1XGN A;  4FLI A;  2EVO A;  1QZY A;  3FMR A;  4FO8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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