4KM3A

Discovery of a novel structural motif in methionine aminopeptidase from streptococci with possible post-translational modification
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
286
structure length
286
Chain Sequence
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a new genetic variant of methionine aminopeptidase from streptococci with possible post-translational modifications: biochemical and structural characterization.
pubmed doi rcsb
source organism Streptococcus pneumoniae
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
total genus 72
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4km3A00
1A16A 2GA2A 4U73A 2BHDA 4KM3A 1XGSA 4ZWUA 1C27A 4S00A 2B3HA 4IKUA 4RZYA 1O0XA 1XGNA 2HOWA 2BWYA 2GG5A 5JFRA 2B3KA 4Z7MA 1WLRA 5CDEA 3CB5A 1WBQA 1W7VA 3PKEA 3S6BA 1BN5A 1R58A 3PKDA 1W2MA 4IPAA 5JHUA 1C24A 4U76A 5FCFA 2EVMA 2Q95A 2GG3A 1C21A 1CHMA 3Q6DA 3CB6A 2Q8KA 3D27A 2GU6A 4ZNGA 5FCHA 2BN7A 2V6CA 4MATA 5CDVA 2IW2A 1WL9A 2EVOA 4IECA 4FO8A 4U6WA 5E5BA 2OKNA 4IKSA 4IF7A 4IKRA 1QZYA 5CDLA 4U6EA 1YW9A 4FLLA 1B59A 2EVCA 1KQ9A 1C22A 4S2RP 4HXXA 2V3XA 4FUKA 3FM3A 2GG0A 4U6ZA 4ZWOA 4U69A 3MATA 1C23A 2B3LA 2EA2A 2GU5A 4QR8A 3RORA 3BIQA 3IU8A 4A6WA 1XGMA 4B28A 4U70A 3BIPA 2GG9A 1BOAA 2BWUA 2GGCA 3BITA 4FO7A 2BWSA 1R5GA 2P99A 3TB5A 4A6VA 3IU7A 3FMRA 1YW7A 5CIKA 4R60A 1WN1A 1Y1NA 4ZWPA 4IU6A 1PV9A 4OOKA 2GG7A 3IG4A 4RZZA 3PKBA 1KP0A 2OAZA 2G6PA 4FLJA 3L7GA 2Q93A 4U75A 2DFIA 5CLSA 2GTXA 3FMQA 2GG8A 2BWWA 2GG2A 2P9AA 4EGEA 2BB7A 3MX6A 1YVMA 5JI6A 5D6FA 1M35A 2BHCA 2Q94A 4IKTA 2MATA 4JUQA 4U6CA 5D6EA 2BWVA 2V3ZA 2GU7A 4FKCA 1QXZA 4S2TP 1KQ0A 1XNZA 1R5HA 4PV4A 3RVAA 1WY2A 3IU9A 2BHAA 3L24A 2NQ7A 3TAVA 2BHBA 1QXWA 2BH3A 3PKAA 1B6AA 1YJ3A 3MR1A 2P98A 2ADUA 2EA4A 1WL6A 4U6JA 2NQ6A 4FLKA 2Q96A 4IDYA 2GU4A 4RGZ1 1YW8A 1JAWA 2BWXA 3CTZA 5CNXA 2ZSGA 1XGOA 2GGBA 1MATA 2Q92A 5CE6A 3PKCA 2BWTA 4FLIA 1QXYA 4U1BA 2GZ5A 4PNCA 4S01A 4U71A 1N51A 1WKMA 2V3YA
chains in the Genus database with same CATH superfamily
1A16A 2GA2A 4U73A 2BHDA 4KM3A 1XGSA 4ZWUA 1C27A 4S00A 2B3HA 4IKUA 4RZYA 1O0XA 1XGNA 2HOWA 2BWYA 2GG5A 5JFRA 2B3KA 4Z7MA 1WLRA 5CDEA 3CB5A 1WBQA 1W7VA 3PKEA 3S6BA 1BN5A 1R58A 3PKDA 1W2MA 4IPAA 5JHUA 1C24A 4U76A 5FCFA 2EVMA 2Q95A 2GG3A 1C21A 1CHMA 3Q6DA 3CB6A 2Q8KA 3D27A 2GU6A 4ZNGA 5FCHA 2BN7A 2V6CA 4MATA 5CDVA 2IW2A 1WL9A 2EVOA 4IECA 4FO8A 4U6WA 5E5BA 2OKNA 4IKSA 4IF7A 4IKRA 1QZYA 5CDLA 4U6EA 1YW9A 4FLLA 1B59A 2EVCA 1KQ9A 1C22A 4S2RP 4HXXA 2V3XA 4FUKA 3FM3A 2GG0A 4U6ZA 4ZWOA 4U69A 3MATA 1C23A 2B3LA 2EA2A 2GU5A 4QR8A 3RORA 3BIQA 3IU8A 4A6WA 1XGMA 4B28A 4U70A 3BIPA 2GG9A 1BOAA 2BWUA 2GGCA 3BITA 4FO7A 2BWSA 1R5GA 2P99A 3TB5A 4A6VA 3IU7A 3FMRA 1YW7A 5CIKA 4R60A 1WN1A 1Y1NA 4ZWPA 4IU6A 1PV9A 4OOKA 2GG7A 3IG4A 4RZZA 3PKBA 1KP0A 2OAZA 2G6PA 4FLJA 3L7GA 2Q93A 4U75A 2DFIA 5CLSA 2GTXA 3FMQA 2GG8A 2BWWA 2GG2A 2P9AA 4EGEA 2BB7A 3MX6A 1YVMA 5JI6A 5D6FA 1M35A 2BHCA 2Q94A 4IKTA 2MATA 4JUQA 4U6CA 5D6EA 2BWVA 2V3ZA 2GU7A 4FKCA 1QXZA 4S2TP 1KQ0A 1XNZA 1R5HA 4PV4A 3RVAA 1WY2A 3IU9A 2BHAA 3L24A 2NQ7A 3TAVA 2BHBA 1QXWA 2BH3A 3PKAA 1B6AA 1YJ3A 3MR1A 2P98A 2ADUA 2EA4A 1WL6A 4U6JA 2NQ6A 4FLKA 2Q96A 4IDYA 2GU4A 4RGZ1 1YW8A 1JAWA 2BWXA 3CTZA 5CNXA 2ZSGA 1XGOA 2GGBA 1MATA 2Q92A 5CE6A 3PKCA 2BWTA 4FLIA 1QXYA 4U1BA 2GZ5A 4PNCA 4S01A 4U71A 1N51A 1WKMA 2V3YA
chains in the Genus database with same CATH topology
1A16A 2GA2A 4U73A 2BHDA 4KM3A 1XGSA 4ZWUA 1C27A 4S00A 2B3HA 4IKUA 4RZYA 1O0XA 1XGNA 2HOWA 2BWYA 2GG5A 5JFRA 2B3KA 4Z7MA 1WLRA 5CDEA 3CB5A 1WBQA 1W7VA 3PKEA 3S6BA 1BN5A 1R58A 3PKDA 1W2MA 4IPAA 5JHUA 1C24A 4U76A 5FCFA 2EVMA 2Q95A 2GG3A 1C21A 1CHMA 3Q6DA 3CB6A 2Q8KA 3D27A 2GU6A 4ZNGA 5FCHA 2BN7A 2V6CA 4MATA 5CDVA 2IW2A 1WL9A 2EVOA 4IECA 4FO8A 4U6WA 5E5BA 2OKNA 4IKSA 4IF7A 4IKRA 1QZYA 5CDLA 4U6EA 1YW9A 4FLLA 1B59A 2EVCA 1KQ9A 1C22A 4S2RP 4HXXA 2V3XA 4FUKA 3FM3A 2GG0A 4U6ZA 4ZWOA 4U69A 3MATA 1C23A 2B3LA 2EA2A 2GU5A 4QR8A 3RORA 3BIQA 3IU8A 4A6WA 1XGMA 4B28A 4U70A 3BIPA 2GG9A 1BOAA 2BWUA 2GGCA 3BITA 4FO7A 2BWSA 1R5GA 2P99A 3TB5A 4A6VA 3IU7A 3FMRA 1YW7A 5CIKA 4R60A 1WN1A 1Y1NA 4ZWPA 4IU6A 1PV9A 4OOKA 2GG7A 3IG4A 4RZZA 3PKBA 1KP0A 2OAZA 2G6PA 4FLJA 3L7GA 2Q93A 4U75A 2DFIA 5CLSA 2GTXA 3FMQA 2GG8A 2BWWA 2GG2A 2P9AA 4EGEA 2BB7A 3MX6A 1YVMA 5JI6A 5D6FA 1M35A 2BHCA 2Q94A 4IKTA 2MATA 4JUQA 4U6CA 5D6EA 2BWVA 2V3ZA 2GU7A 4FKCA 1QXZA 4S2TP 1KQ0A 1XNZA 1R5HA 4PV4A 3RVAA 1WY2A 3IU9A 2BHAA 3L24A 2NQ7A 3TAVA 2BHBA 1QXWA 2BH3A 3PKAA 1B6AA 1YJ3A 3MR1A 2P98A 2ADUA 2EA4A 1WL6A 4U6JA 2NQ6A 4FLKA 2Q96A 4IDYA 2GU4A 4RGZ1 1YW8A 1JAWA 2BWXA 3CTZA 5CNXA 2ZSGA 1XGOA 2GGBA 1MATA 2Q92A 5CE6A 3PKCA 2BWTA 4FLIA 1QXYA 4U1BA 2GZ5A 4PNCA 4S01A 4U71A 1N51A 1WKMA 2V3YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A16 A;  2GA2 A;  4U73 A;  2BHD A;  4KM3 A;  1XGS A;  4ZWU A;  1C27 A;  4S00 A;  2B3H A;  4IKU A;  4RZY A;  1O0X A;  1XGN A;  2HOW A;  2BWY A;  2GG5 A;  5JFR A;  2B3K A;  4Z7M A;  1WLR A;  5CDE A;  3CB5 A;  1WBQ A;  1W7V A;  3PKE A;  3S6B A;  1BN5 A;  1R58 A;  3PKD A;  1W2M A;  4IPA A;  5JHU A;  1C24 A;  4U76 A;  5FCF A;  2EVM A;  2Q95 A;  2GG3 A;  1C21 A;  1CHM A;  3Q6D A;  3CB6 A;  2Q8K A;  3D27 A;  2GU6 A;  4ZNG A;  5FCH A;  2BN7 A;  2V6C A;  4MAT A;  5CDV A;  2IW2 A;  1WL9 A;  2EVO A;  4IEC A;  4FO8 A;  4U6W A;  5E5B A;  2OKN A;  4IKS A;  4IF7 A;  4IKR A;  1QZY A;  5CDL A;  4U6E A;  1YW9 A;  4FLL A;  1B59 A;  2EVC A;  1KQ9 A;  1C22 A;  4S2R P;  4HXX A;  2V3X A;  4FUK A;  3FM3 A;  2GG0 A;  4U6Z A;  4ZWO A;  4U69 A;  3MAT A;  1C23 A;  2B3L A;  2EA2 A;  2GU5 A;  4QR8 A;  3ROR A;  3BIQ A;  3IU8 A;  4A6W A;  1XGM A;  4B28 A;  4U70 A;  3BIP A;  2GG9 A;  1BOA A;  2BWU A;  2GGC A;  3BIT A;  4FO7 A;  2BWS A;  1R5G A;  2P99 A;  3TB5 A;  4A6V A;  3IU7 A;  3FMR A;  1YW7 A;  5CIK A;  4R60 A;  1WN1 A;  1Y1N A;  4ZWP A;  4IU6 A;  1PV9 A;  4OOK A;  2GG7 A;  3IG4 A;  4RZZ A;  3PKB A;  1KP0 A;  2OAZ A;  2G6P A;  4FLJ A;  3L7G A;  2Q93 A;  4U75 A;  2DFI A;  5CLS A;  2GTX A;  3FMQ A;  2GG8 A;  2BWW A;  2GG2 A;  2P9A A;  4EGE A;  2BB7 A;  3MX6 A;  1YVM A;  5JI6 A;  5D6F A;  1M35 A;  2BHC A;  2Q94 A;  4IKT A;  2MAT A;  4JUQ A;  4U6C A;  5D6E A;  2BWV A;  2V3Z A;  2GU7 A;  4FKC A;  1QXZ A;  4S2T P;  1KQ0 A;  1XNZ A;  1R5H A;  4PV4 A;  3RVA A;  1WY2 A;  3IU9 A;  2BHA A;  3L24 A;  2NQ7 A;  3TAV A;  2BHB A;  1QXW A;  2BH3 A;  3PKA A;  1B6A A;  1YJ3 A;  3MR1 A;  2P98 A;  2ADU A;  2EA4 A;  1WL6 A;  4U6J A;  2NQ6 A;  4FLK A;  2Q96 A;  4IDY A;  2GU4 A;  4RGZ 1;  1YW8 A;  1JAW A;  2BWX A;  3CTZ A;  5CNX A;  2ZSG A;  1XGO A;  2GGB A;  1MAT A;  2Q92 A;  5CE6 A;  3PKC A;  2BWT A;  4FLI A;  1QXY A;  4U1B A;  2GZ5 A;  4PNC A;  4S01 A;  4U71 A;  1N51 A;  1WKM A;  2V3Y A; 
#chains in the Genus database with same CATH topology
 1A16 A;  2GA2 A;  4U73 A;  2BHD A;  4KM3 A;  1XGS A;  4ZWU A;  1C27 A;  4S00 A;  2B3H A;  4IKU A;  4RZY A;  1O0X A;  1XGN A;  2HOW A;  2BWY A;  2GG5 A;  5JFR A;  2B3K A;  4Z7M A;  1WLR A;  5CDE A;  3CB5 A;  1WBQ A;  1W7V A;  3PKE A;  3S6B A;  1BN5 A;  1R58 A;  3PKD A;  1W2M A;  4IPA A;  5JHU A;  1C24 A;  4U76 A;  5FCF A;  2EVM A;  2Q95 A;  2GG3 A;  1C21 A;  1CHM A;  3Q6D A;  3CB6 A;  2Q8K A;  3D27 A;  2GU6 A;  4ZNG A;  5FCH A;  2BN7 A;  2V6C A;  4MAT A;  5CDV A;  2IW2 A;  1WL9 A;  2EVO A;  4IEC A;  4FO8 A;  4U6W A;  5E5B A;  2OKN A;  4IKS A;  4IF7 A;  4IKR A;  1QZY A;  5CDL A;  4U6E A;  1YW9 A;  4FLL A;  1B59 A;  2EVC A;  1KQ9 A;  1C22 A;  4S2R P;  4HXX A;  2V3X A;  4FUK A;  3FM3 A;  2GG0 A;  4U6Z A;  4ZWO A;  4U69 A;  3MAT A;  1C23 A;  2B3L A;  2EA2 A;  2GU5 A;  4QR8 A;  3ROR A;  3BIQ A;  3IU8 A;  4A6W A;  1XGM A;  4B28 A;  4U70 A;  3BIP A;  2GG9 A;  1BOA A;  2BWU A;  2GGC A;  3BIT A;  4FO7 A;  2BWS A;  1R5G A;  2P99 A;  3TB5 A;  4A6V A;  3IU7 A;  3FMR A;  1YW7 A;  5CIK A;  4R60 A;  1WN1 A;  1Y1N A;  4ZWP A;  4IU6 A;  1PV9 A;  4OOK A;  2GG7 A;  3IG4 A;  4RZZ A;  3PKB A;  1KP0 A;  2OAZ A;  2G6P A;  4FLJ A;  3L7G A;  2Q93 A;  4U75 A;  2DFI A;  5CLS A;  2GTX A;  3FMQ A;  2GG8 A;  2BWW A;  2GG2 A;  2P9A A;  4EGE A;  2BB7 A;  3MX6 A;  1YVM A;  5JI6 A;  5D6F A;  1M35 A;  2BHC A;  2Q94 A;  4IKT A;  2MAT A;  4JUQ A;  4U6C A;  5D6E A;  2BWV A;  2V3Z A;  2GU7 A;  4FKC A;  1QXZ A;  4S2T P;  1KQ0 A;  1XNZ A;  1R5H A;  4PV4 A;  3RVA A;  1WY2 A;  3IU9 A;  2BHA A;  3L24 A;  2NQ7 A;  3TAV A;  2BHB A;  1QXW A;  2BH3 A;  3PKA A;  1B6A A;  1YJ3 A;  3MR1 A;  2P98 A;  2ADU A;  2EA4 A;  1WL6 A;  4U6J A;  2NQ6 A;  4FLK A;  2Q96 A;  4IDY A;  2GU4 A;  4RGZ 1;  1YW8 A;  1JAW A;  2BWX A;  3CTZ A;  5CNX A;  2ZSG A;  1XGO A;  2GGB A;  1MAT A;  2Q92 A;  5CE6 A;  3PKC A;  2BWT A;  4FLI A;  1QXY A;  4U1B A;  2GZ5 A;  4PNC A;  4S01 A;  4U71 A;  1N51 A;  1WKM A;  2V3Y A; 
#chains in the Genus database with same CATH homology
 1A16 A;  2GA2 A;  4U73 A;  2BHD A;  4KM3 A;  1XGS A;  4ZWU A;  1C27 A;  4S00 A;  2B3H A;  4IKU A;  4RZY A;  1O0X A;  1XGN A;  2HOW A;  2BWY A;  2GG5 A;  5JFR A;  2B3K A;  4Z7M A;  1WLR A;  5CDE A;  3CB5 A;  1WBQ A;  1W7V A;  3PKE A;  3S6B A;  1BN5 A;  1R58 A;  3PKD A;  1W2M A;  4IPA A;  5JHU A;  1C24 A;  4U76 A;  5FCF A;  2EVM A;  2Q95 A;  2GG3 A;  1C21 A;  1CHM A;  3Q6D A;  3CB6 A;  2Q8K A;  3D27 A;  2GU6 A;  4ZNG A;  5FCH A;  2BN7 A;  2V6C A;  4MAT A;  5CDV A;  2IW2 A;  1WL9 A;  2EVO A;  4IEC A;  4FO8 A;  4U6W A;  5E5B A;  2OKN A;  4IKS A;  4IF7 A;  4IKR A;  1QZY A;  5CDL A;  4U6E A;  1YW9 A;  4FLL A;  1B59 A;  2EVC A;  1KQ9 A;  1C22 A;  4S2R P;  4HXX A;  2V3X A;  4FUK A;  3FM3 A;  2GG0 A;  4U6Z A;  4ZWO A;  4U69 A;  3MAT A;  1C23 A;  2B3L A;  2EA2 A;  2GU5 A;  4QR8 A;  3ROR A;  3BIQ A;  3IU8 A;  4A6W A;  1XGM A;  4B28 A;  4U70 A;  3BIP A;  2GG9 A;  1BOA A;  2BWU A;  2GGC A;  3BIT A;  4FO7 A;  2BWS A;  1R5G A;  2P99 A;  3TB5 A;  4A6V A;  3IU7 A;  3FMR A;  1YW7 A;  5CIK A;  4R60 A;  1WN1 A;  1Y1N A;  4ZWP A;  4IU6 A;  1PV9 A;  4OOK A;  2GG7 A;  3IG4 A;  4RZZ A;  3PKB A;  1KP0 A;  2OAZ A;  2G6P A;  4FLJ A;  3L7G A;  2Q93 A;  4U75 A;  2DFI A;  5CLS A;  2GTX A;  3FMQ A;  2GG8 A;  2BWW A;  2GG2 A;  2P9A A;  4EGE A;  2BB7 A;  3MX6 A;  1YVM A;  5JI6 A;  5D6F A;  1M35 A;  2BHC A;  2Q94 A;  4IKT A;  2MAT A;  4JUQ A;  4U6C A;  5D6E A;  2BWV A;  2V3Z A;  2GU7 A;  4FKC A;  1QXZ A;  4S2T P;  1KQ0 A;  1XNZ A;  1R5H A;  4PV4 A;  3RVA A;  1WY2 A;  3IU9 A;  2BHA A;  3L24 A;  2NQ7 A;  3TAV A;  2BHB A;  1QXW A;  2BH3 A;  3PKA A;  1B6A A;  1YJ3 A;  3MR1 A;  2P98 A;  2ADU A;  2EA4 A;  1WL6 A;  4U6J A;  2NQ6 A;  4FLK A;  2Q96 A;  4IDY A;  2GU4 A;  4RGZ 1;  1YW8 A;  1JAW A;  2BWX A;  3CTZ A;  5CNX A;  2ZSG A;  1XGO A;  2GGB A;  1MAT A;  2Q92 A;  5CE6 A;  3PKC A;  2BWT A;  4FLI A;  1QXY A;  4U1B A;  2GZ5 A;  4PNC A;  4S01 A;  4U71 A;  1N51 A;  1WKM A;  2V3Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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