4KM3A

Discovery of a novel structural motif in methionine aminopeptidase from streptococci with possible post-translational modification
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
286
structure length
286
Chain Sequence
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Discovery of a new genetic variant of methionine aminopeptidase from streptococci with possible post-translational modifications: biochemical and structural characterization.
pubmed doi rcsb
source organism Streptococcus pneumoniae
total genus 72
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4km3A00
1XGSA 2GU7A 2BWVA 4QR8A 2Q8KA 4U6EA 4A6VA 3CTZA 1YVMA 2GGCA 1W2MA 2OKNA 4IPAA 4IKSA 3RVAA 1B59A 2V3YA 2GTXA 4S01A 2GG5A 2V3XA 2Q96A 1JAWA 2DFIA 4S2RP 1QXZA 4R60A 1M35A 3BITA 4U69A 5CLSA 1C27A 1BOAA 4FLKA 2V3ZA 3IU8A 2ZSGA 4IF7A 3TB5A 4U6WA 1W7VA 4ZWOA 4FLLA 2NQ6A 1R5GA 4U70A 5D6EA 4IKUA 3CB5A 4FO8A 3S6BA 2EVOA 1BN5A 2OAZA 2GG9A 3MATA 3FMRA 4FO7A 2Q94A 2HOWA 5E5BA 4B28A 2V6CA 4A6WA 2ADUA 1QXWA 3Q6DA 1CHMA 2BH3A 4U1BA 1Y1NA 1XGOA 5FCFA 4ZNGA 2BHDA 2GGBA 1C24A 5CNXA 4Z7MA 4KM3A 1A16A 2BWYA 4RGZ1 2EA4A 1N51A 1WBQA 1QZYA 4U6JA 1WY2A 5JI6A 4OOKA 2Q92A 3L7GA 4HXXA 2BHCA 4U71A 1XGMA 3PKDA 4U75A 2Q93A 4U73A 4FLIA 2BWWA 4FUKA 2GG8A 4RZZA 2MATA 1KQ0A 1WN1A 2P98A 2BWXA 1WL6A 2B3KA 2BWTA 5D6FA 3FMQA 4IU6A 4PNCA 2BN7A 3BIQA 3PKBA 1PV9A 3PKCA 5CDEA 4S00A 2B3LA 1B6AA 1YW7A 2Q95A 4S2TP 2B3HA 2GU5A 1YW8A 3PKEA 5FCHA 5CDLA 4ZWPA 5CIKA 2EVCA 4RZYA 4ZWUA 1XGNA 1KQ9A 3IU9A 3IU7A 2P9AA 3MR1A 4FKCA 1XNZA 2EA2A 4U76A 4JUQA 2GG3A 2GU4A 2IW2A 4IKTA 2G6PA 5JHUA 2BHBA 4FLJA 4PV4A 3FM3A 1WL9A 4IECA 3IG4A 5CE6A 3BIPA 4U6CA 2NQ7A 2GG2A 1KP0A 1MATA 2BWUA 2P99A 3D27A 2GU6A 3CB6A 2GA2A 4MATA 1C21A 1YJ3A 2GZ5A 3L24A 1C22A 3TAVA 1QXYA 2GG0A 5CDVA 5JFRA 3MX6A 4U6ZA 2BWSA 1R58A 1YW9A 1WLRA 2BB7A 3RORA 4IDYA 3PKAA 1O0XA 1WKMA 1C23A 4IKRA 2EVMA 1R5HA 2BHAA 4EGEA 2GG7A
chains in the Genus database with same CATH superfamily
1XGSA 2GU7A 2BWVA 4QR8A 2Q8KA 4U6EA 4A6VA 3CTZA 1YVMA 2GGCA 1W2MA 2OKNA 4IPAA 4IKSA 3RVAA 1B59A 2V3YA 2GTXA 4S01A 2GG5A 2V3XA 2Q96A 1JAWA 2DFIA 4S2RP 1QXZA 4R60A 1M35A 3BITA 4U69A 5CLSA 1C27A 1BOAA 4FLKA 2V3ZA 3IU8A 2ZSGA 4IF7A 3TB5A 4U6WA 1W7VA 4ZWOA 4FLLA 2NQ6A 1R5GA 4U70A 5D6EA 4IKUA 3CB5A 4FO8A 3S6BA 2EVOA 1BN5A 2OAZA 2GG9A 3MATA 3FMRA 4FO7A 2Q94A 2HOWA 5E5BA 4B28A 2V6CA 4A6WA 2ADUA 1QXWA 3Q6DA 1CHMA 2BH3A 4U1BA 1Y1NA 1XGOA 5FCFA 4ZNGA 2BHDA 2GGBA 1C24A 5CNXA 4Z7MA 4KM3A 1A16A 2BWYA 4RGZ1 2EA4A 1N51A 1WBQA 1QZYA 4U6JA 1WY2A 5JI6A 4OOKA 2Q92A 3L7GA 4HXXA 2BHCA 4U71A 1XGMA 3PKDA 4U75A 2Q93A 4U73A 4FLIA 2BWWA 4FUKA 2GG8A 4RZZA 2MATA 1KQ0A 1WN1A 2P98A 2BWXA 1WL6A 2B3KA 2BWTA 5D6FA 3FMQA 4IU6A 4PNCA 2BN7A 3BIQA 3PKBA 1PV9A 3PKCA 5CDEA 4S00A 2B3LA 1B6AA 1YW7A 2Q95A 4S2TP 2B3HA 2GU5A 1YW8A 3PKEA 5FCHA 5CDLA 4ZWPA 5CIKA 2EVCA 4RZYA 4ZWUA 1XGNA 1KQ9A 3IU9A 3IU7A 2P9AA 3MR1A 4FKCA 1XNZA 2EA2A 4U76A 4JUQA 2GG3A 2GU4A 2IW2A 4IKTA 2G6PA 5JHUA 2BHBA 4FLJA 4PV4A 3FM3A 1WL9A 4IECA 3IG4A 5CE6A 3BIPA 4U6CA 2NQ7A 2GG2A 1KP0A 1MATA 2BWUA 2P99A 3D27A 2GU6A 3CB6A 2GA2A 4MATA 1C21A 1YJ3A 2GZ5A 3L24A 1C22A 3TAVA 1QXYA 2GG0A 5CDVA 5JFRA 3MX6A 4U6ZA 2BWSA 1R58A 1YW9A 1WLRA 2BB7A 3RORA 4IDYA 3PKAA 1O0XA 1WKMA 1C23A 4IKRA 2EVMA 1R5HA 2BHAA 4EGEA 2GG7A
chains in the Genus database with same CATH topology
1XGSA 2GU7A 2BWVA 4QR8A 2Q8KA 4U6EA 4A6VA 3CTZA 1YVMA 2GGCA 1W2MA 2OKNA 4IPAA 4IKSA 3RVAA 1B59A 2V3YA 2GTXA 4S01A 2GG5A 2V3XA 2Q96A 1JAWA 2DFIA 4S2RP 1QXZA 4R60A 1M35A 3BITA 4U69A 5CLSA 1C27A 1BOAA 4FLKA 2V3ZA 3IU8A 2ZSGA 4IF7A 3TB5A 4U6WA 1W7VA 4ZWOA 4FLLA 2NQ6A 1R5GA 4U70A 5D6EA 4IKUA 3CB5A 4FO8A 3S6BA 2EVOA 1BN5A 2OAZA 2GG9A 3MATA 3FMRA 4FO7A 2Q94A 2HOWA 5E5BA 4B28A 2V6CA 4A6WA 2ADUA 1QXWA 3Q6DA 1CHMA 2BH3A 4U1BA 1Y1NA 1XGOA 5FCFA 4ZNGA 2BHDA 2GGBA 1C24A 5CNXA 4Z7MA 4KM3A 1A16A 2BWYA 4RGZ1 2EA4A 1N51A 1WBQA 1QZYA 4U6JA 1WY2A 5JI6A 4OOKA 2Q92A 3L7GA 4HXXA 2BHCA 4U71A 1XGMA 3PKDA 4U75A 2Q93A 4U73A 4FLIA 2BWWA 4FUKA 2GG8A 4RZZA 2MATA 1KQ0A 1WN1A 2P98A 2BWXA 1WL6A 2B3KA 2BWTA 5D6FA 3FMQA 4IU6A 4PNCA 2BN7A 3BIQA 3PKBA 1PV9A 3PKCA 5CDEA 4S00A 2B3LA 1B6AA 1YW7A 2Q95A 4S2TP 2B3HA 2GU5A 1YW8A 3PKEA 5FCHA 5CDLA 4ZWPA 5CIKA 2EVCA 4RZYA 4ZWUA 1XGNA 1KQ9A 3IU9A 3IU7A 2P9AA 3MR1A 4FKCA 1XNZA 2EA2A 4U76A 4JUQA 2GG3A 2GU4A 2IW2A 4IKTA 2G6PA 5JHUA 2BHBA 4FLJA 4PV4A 3FM3A 1WL9A 4IECA 3IG4A 5CE6A 3BIPA 4U6CA 2NQ7A 2GG2A 1KP0A 1MATA 2BWUA 2P99A 3D27A 2GU6A 3CB6A 2GA2A 4MATA 1C21A 1YJ3A 2GZ5A 3L24A 1C22A 3TAVA 1QXYA 2GG0A 5CDVA 5JFRA 3MX6A 4U6ZA 2BWSA 1R58A 1YW9A 1WLRA 2BB7A 3RORA 4IDYA 3PKAA 1O0XA 1WKMA 1C23A 4IKRA 2EVMA 1R5HA 2BHAA 4EGEA 2GG7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XGS A;  2GU7 A;  2BWV A;  4QR8 A;  2Q8K A;  4U6E A;  4A6V A;  3CTZ A;  1YVM A;  2GGC A;  1W2M A;  2OKN A;  4IPA A;  4IKS A;  3RVA A;  1B59 A;  2V3Y A;  2GTX A;  4S01 A;  2GG5 A;  2V3X A;  2Q96 A;  1JAW A;  2DFI A;  4S2R P;  1QXZ A;  4R60 A;  1M35 A;  3BIT A;  4U69 A;  5CLS A;  1C27 A;  1BOA A;  4FLK A;  2V3Z A;  3IU8 A;  2ZSG A;  4IF7 A;  3TB5 A;  4U6W A;  1W7V A;  4ZWO A;  4FLL A;  2NQ6 A;  1R5G A;  4U70 A;  5D6E A;  4IKU A;  3CB5 A;  4FO8 A;  3S6B A;  2EVO A;  1BN5 A;  2OAZ A;  2GG9 A;  3MAT A;  3FMR A;  4FO7 A;  2Q94 A;  2HOW A;  5E5B A;  4B28 A;  2V6C A;  4A6W A;  2ADU A;  1QXW A;  3Q6D A;  1CHM A;  2BH3 A;  4U1B A;  1Y1N A;  1XGO A;  5FCF A;  4ZNG A;  2BHD A;  2GGB A;  1C24 A;  5CNX A;  4Z7M A;  4KM3 A;  1A16 A;  2BWY A;  4RGZ 1;  2EA4 A;  1N51 A;  1WBQ A;  1QZY A;  4U6J A;  1WY2 A;  5JI6 A;  4OOK A;  2Q92 A;  3L7G A;  4HXX A;  2BHC A;  4U71 A;  1XGM A;  3PKD A;  4U75 A;  2Q93 A;  4U73 A;  4FLI A;  2BWW A;  4FUK A;  2GG8 A;  4RZZ A;  2MAT A;  1KQ0 A;  1WN1 A;  2P98 A;  2BWX A;  1WL6 A;  2B3K A;  2BWT A;  5D6F A;  3FMQ A;  4IU6 A;  4PNC A;  2BN7 A;  3BIQ A;  3PKB A;  1PV9 A;  3PKC A;  5CDE A;  4S00 A;  2B3L A;  1B6A A;  1YW7 A;  2Q95 A;  4S2T P;  2B3H A;  2GU5 A;  1YW8 A;  3PKE A;  5FCH A;  5CDL A;  4ZWP A;  5CIK A;  2EVC A;  4RZY A;  4ZWU A;  1XGN A;  1KQ9 A;  3IU9 A;  3IU7 A;  2P9A A;  3MR1 A;  4FKC A;  1XNZ A;  2EA2 A;  4U76 A;  4JUQ A;  2GG3 A;  2GU4 A;  2IW2 A;  4IKT A;  2G6P A;  5JHU A;  2BHB A;  4FLJ A;  4PV4 A;  3FM3 A;  1WL9 A;  4IEC A;  3IG4 A;  5CE6 A;  3BIP A;  4U6C A;  2NQ7 A;  2GG2 A;  1KP0 A;  1MAT A;  2BWU A;  2P99 A;  3D27 A;  2GU6 A;  3CB6 A;  2GA2 A;  4MAT A;  1C21 A;  1YJ3 A;  2GZ5 A;  3L24 A;  1C22 A;  3TAV A;  1QXY A;  2GG0 A;  5CDV A;  5JFR A;  3MX6 A;  4U6Z A;  2BWS A;  1R58 A;  1YW9 A;  1WLR A;  2BB7 A;  3ROR A;  4IDY A;  3PKA A;  1O0X A;  1WKM A;  1C23 A;  4IKR A;  2EVM A;  1R5H A;  2BHA A;  4EGE A;  2GG7 A; 
#chains in the Genus database with same CATH topology
 1XGS A;  2GU7 A;  2BWV A;  4QR8 A;  2Q8K A;  4U6E A;  4A6V A;  3CTZ A;  1YVM A;  2GGC A;  1W2M A;  2OKN A;  4IPA A;  4IKS A;  3RVA A;  1B59 A;  2V3Y A;  2GTX A;  4S01 A;  2GG5 A;  2V3X A;  2Q96 A;  1JAW A;  2DFI A;  4S2R P;  1QXZ A;  4R60 A;  1M35 A;  3BIT A;  4U69 A;  5CLS A;  1C27 A;  1BOA A;  4FLK A;  2V3Z A;  3IU8 A;  2ZSG A;  4IF7 A;  3TB5 A;  4U6W A;  1W7V A;  4ZWO A;  4FLL A;  2NQ6 A;  1R5G A;  4U70 A;  5D6E A;  4IKU A;  3CB5 A;  4FO8 A;  3S6B A;  2EVO A;  1BN5 A;  2OAZ A;  2GG9 A;  3MAT A;  3FMR A;  4FO7 A;  2Q94 A;  2HOW A;  5E5B A;  4B28 A;  2V6C A;  4A6W A;  2ADU A;  1QXW A;  3Q6D A;  1CHM A;  2BH3 A;  4U1B A;  1Y1N A;  1XGO A;  5FCF A;  4ZNG A;  2BHD A;  2GGB A;  1C24 A;  5CNX A;  4Z7M A;  4KM3 A;  1A16 A;  2BWY A;  4RGZ 1;  2EA4 A;  1N51 A;  1WBQ A;  1QZY A;  4U6J A;  1WY2 A;  5JI6 A;  4OOK A;  2Q92 A;  3L7G A;  4HXX A;  2BHC A;  4U71 A;  1XGM A;  3PKD A;  4U75 A;  2Q93 A;  4U73 A;  4FLI A;  2BWW A;  4FUK A;  2GG8 A;  4RZZ A;  2MAT A;  1KQ0 A;  1WN1 A;  2P98 A;  2BWX A;  1WL6 A;  2B3K A;  2BWT A;  5D6F A;  3FMQ A;  4IU6 A;  4PNC A;  2BN7 A;  3BIQ A;  3PKB A;  1PV9 A;  3PKC A;  5CDE A;  4S00 A;  2B3L A;  1B6A A;  1YW7 A;  2Q95 A;  4S2T P;  2B3H A;  2GU5 A;  1YW8 A;  3PKE A;  5FCH A;  5CDL A;  4ZWP A;  5CIK A;  2EVC A;  4RZY A;  4ZWU A;  1XGN A;  1KQ9 A;  3IU9 A;  3IU7 A;  2P9A A;  3MR1 A;  4FKC A;  1XNZ A;  2EA2 A;  4U76 A;  4JUQ A;  2GG3 A;  2GU4 A;  2IW2 A;  4IKT A;  2G6P A;  5JHU A;  2BHB A;  4FLJ A;  4PV4 A;  3FM3 A;  1WL9 A;  4IEC A;  3IG4 A;  5CE6 A;  3BIP A;  4U6C A;  2NQ7 A;  2GG2 A;  1KP0 A;  1MAT A;  2BWU A;  2P99 A;  3D27 A;  2GU6 A;  3CB6 A;  2GA2 A;  4MAT A;  1C21 A;  1YJ3 A;  2GZ5 A;  3L24 A;  1C22 A;  3TAV A;  1QXY A;  2GG0 A;  5CDV A;  5JFR A;  3MX6 A;  4U6Z A;  2BWS A;  1R58 A;  1YW9 A;  1WLR A;  2BB7 A;  3ROR A;  4IDY A;  3PKA A;  1O0X A;  1WKM A;  1C23 A;  4IKR A;  2EVM A;  1R5H A;  2BHA A;  4EGE A;  2GG7 A; 
#chains in the Genus database with same CATH homology
 1XGS A;  2GU7 A;  2BWV A;  4QR8 A;  2Q8K A;  4U6E A;  4A6V A;  3CTZ A;  1YVM A;  2GGC A;  1W2M A;  2OKN A;  4IPA A;  4IKS A;  3RVA A;  1B59 A;  2V3Y A;  2GTX A;  4S01 A;  2GG5 A;  2V3X A;  2Q96 A;  1JAW A;  2DFI A;  4S2R P;  1QXZ A;  4R60 A;  1M35 A;  3BIT A;  4U69 A;  5CLS A;  1C27 A;  1BOA A;  4FLK A;  2V3Z A;  3IU8 A;  2ZSG A;  4IF7 A;  3TB5 A;  4U6W A;  1W7V A;  4ZWO A;  4FLL A;  2NQ6 A;  1R5G A;  4U70 A;  5D6E A;  4IKU A;  3CB5 A;  4FO8 A;  3S6B A;  2EVO A;  1BN5 A;  2OAZ A;  2GG9 A;  3MAT A;  3FMR A;  4FO7 A;  2Q94 A;  2HOW A;  5E5B A;  4B28 A;  2V6C A;  4A6W A;  2ADU A;  1QXW A;  3Q6D A;  1CHM A;  2BH3 A;  4U1B A;  1Y1N A;  1XGO A;  5FCF A;  4ZNG A;  2BHD A;  2GGB A;  1C24 A;  5CNX A;  4Z7M A;  4KM3 A;  1A16 A;  2BWY A;  4RGZ 1;  2EA4 A;  1N51 A;  1WBQ A;  1QZY A;  4U6J A;  1WY2 A;  5JI6 A;  4OOK A;  2Q92 A;  3L7G A;  4HXX A;  2BHC A;  4U71 A;  1XGM A;  3PKD A;  4U75 A;  2Q93 A;  4U73 A;  4FLI A;  2BWW A;  4FUK A;  2GG8 A;  4RZZ A;  2MAT A;  1KQ0 A;  1WN1 A;  2P98 A;  2BWX A;  1WL6 A;  2B3K A;  2BWT A;  5D6F A;  3FMQ A;  4IU6 A;  4PNC A;  2BN7 A;  3BIQ A;  3PKB A;  1PV9 A;  3PKC A;  5CDE A;  4S00 A;  2B3L A;  1B6A A;  1YW7 A;  2Q95 A;  4S2T P;  2B3H A;  2GU5 A;  1YW8 A;  3PKE A;  5FCH A;  5CDL A;  4ZWP A;  5CIK A;  2EVC A;  4RZY A;  4ZWU A;  1XGN A;  1KQ9 A;  3IU9 A;  3IU7 A;  2P9A A;  3MR1 A;  4FKC A;  1XNZ A;  2EA2 A;  4U76 A;  4JUQ A;  2GG3 A;  2GU4 A;  2IW2 A;  4IKT A;  2G6P A;  5JHU A;  2BHB A;  4FLJ A;  4PV4 A;  3FM3 A;  1WL9 A;  4IEC A;  3IG4 A;  5CE6 A;  3BIP A;  4U6C A;  2NQ7 A;  2GG2 A;  1KP0 A;  1MAT A;  2BWU A;  2P99 A;  3D27 A;  2GU6 A;  3CB6 A;  2GA2 A;  4MAT A;  1C21 A;  1YJ3 A;  2GZ5 A;  3L24 A;  1C22 A;  3TAV A;  1QXY A;  2GG0 A;  5CDV A;  5JFR A;  3MX6 A;  4U6Z A;  2BWS A;  1R58 A;  1YW9 A;  1WLR A;  2BB7 A;  3ROR A;  4IDY A;  3PKA A;  1O0X A;  1WKM A;  1C23 A;  4IKR A;  2EVM A;  1R5H A;  2BHA A;  4EGE A;  2GG7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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