4KM3A

Discovery of a novel structural motif in methionine aminopeptidase from streptococci with possible post-translational modification
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
286
structure length
286
Chain Sequence
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Methionine aminopeptidase
publication title Discovery of a new genetic variant of methionine aminopeptidase from streptococci with possible post-translational modifications: biochemical and structural characterization.
pubmed doi rcsb
source organism Streptococcus pneumoniae
molecule tags Hydrolase
total genus 72
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4km3A00
2P98A 1BOAA 4B28A 3PKAA 1WBQA 4PV4A 4FLJA 1BN5A 1C23A 3D27A 2BH3A 1W7VA 1A16A 4HXXA 2GG2A 2MATA 1JAWA 3RVAA 4S2RP 2GG5A 2GG0A 4R60A 4U6EA 1B6AA 4IKTA 4IKRA 2OAZA 4IKUA 3FMQA 4IU6A 1YVMA 1YW7A 1C21A 1R5GA 4FKCA 2EVCA 4IECA 2GG7A 3FM3A 1W2MA 3CB5A 3IU9A 1KP0A 3PKEA 4A6VA 3L7GA 2GU7A 1XGMA 3MX6A 2Q93A 5CNXA 2BWYA 2BWWA 2HOWA 2V3XA 3IG4A 4IPAA 1WL9A 4S2TP 3Q6DA 5CIKA 4FUKA 2GG8A 3TB5A 4EGEA 4U70A 2BWUA 2GGBA 2GTXA 3BITA 1XNZA 5CE6A 3L24A 5JHUA 4U6WA 5E5BA 1YW8A 4S00A 5CDEA 5D6FA 4A6WA 4Z7MA 2GZ5A 2EVOA 2OKNA 1YW9A 5D6EA 2P9AA 5FCHA 4U6CA 2NQ7A 2G6PA 3IU7A 1QZYA 1WLRA 1Y1NA 2BWSA 4ZWOA 2GU6A 2BWVA 4U75A 4KM3A 2BWTA 3MR1A 4RGZ1 4PNCA 1QXYA 3CB6A 2GG3A 4FLLA 1CHMA 5CDLA 2GG9A 3IU8A 2DFIA 2Q96A 4S01A 4IKSA 2Q8KA 4ZWPA 4FLKA 4U6ZA 1N51A 4IDYA 2BB7A 1O0XA 2BHCA 2Q94A 3BIPA 4RZYA 3RORA 3TAVA 5JI6A 1KQ9A 3FMRA 4FO7A 2Q95A 1R58A 2GA2A 4U1BA 4OOKA 1XGSA 3PKDA 2BWXA 4MATA 2BN7A 2GU5A 5JFRA 4U71A 1PV9A 2EA2A 3BIQA 1M35A 4ZWUA 4QR8A 5FCFA 2GU4A 3PKBA 4FO8A 1MATA 1XGOA 4U6JA 2B3LA 4RZZA 5CDVA 2B3KA 2GGCA 1WKMA 2BHBA 3MATA 1XGNA 2V3ZA 3PKCA 4IF7A 1R5HA 3S6BA 2V3YA 2EVMA 1B59A 2BHDA 1WN1A 4U73A 4ZNGA 2V6CA 4U76A 4JUQA 1QXZA 2EA4A 4FLIA 2Q92A 4U69A 1C27A 2BHAA 2IW2A 1C24A 2ADUA 2B3HA 1KQ0A 1YJ3A 2P99A 1C22A 2ZSGA 1WL6A 2NQ6A 1WY2A 5CLSA 3CTZA 1QXWA
chains in the Genus database with same CATH superfamily
2P98A 1BOAA 4B28A 3PKAA 1WBQA 4PV4A 4FLJA 1BN5A 1C23A 3D27A 2BH3A 1W7VA 1A16A 4HXXA 2GG2A 2MATA 1JAWA 3RVAA 4S2RP 2GG5A 2GG0A 4R60A 4U6EA 1B6AA 4IKTA 4IKRA 2OAZA 4IKUA 3FMQA 4IU6A 1YVMA 1YW7A 1C21A 1R5GA 4FKCA 2EVCA 4IECA 2GG7A 3FM3A 1W2MA 3CB5A 3IU9A 1KP0A 3PKEA 4A6VA 3L7GA 2GU7A 1XGMA 3MX6A 2Q93A 5CNXA 2BWYA 2BWWA 2HOWA 2V3XA 3IG4A 4IPAA 1WL9A 4S2TP 3Q6DA 5CIKA 4FUKA 2GG8A 3TB5A 4EGEA 4U70A 2BWUA 2GGBA 2GTXA 3BITA 1XNZA 5CE6A 3L24A 5JHUA 4U6WA 5E5BA 1YW8A 4S00A 5CDEA 5D6FA 4A6WA 4Z7MA 2GZ5A 2EVOA 2OKNA 1YW9A 5D6EA 2P9AA 5FCHA 4U6CA 2NQ7A 2G6PA 3IU7A 1QZYA 1WLRA 1Y1NA 2BWSA 4ZWOA 2GU6A 2BWVA 4U75A 4KM3A 2BWTA 3MR1A 4RGZ1 4PNCA 1QXYA 3CB6A 2GG3A 4FLLA 1CHMA 5CDLA 2GG9A 3IU8A 2DFIA 2Q96A 4S01A 4IKSA 2Q8KA 4ZWPA 4FLKA 4U6ZA 1N51A 4IDYA 2BB7A 1O0XA 2BHCA 2Q94A 3BIPA 4RZYA 3RORA 3TAVA 5JI6A 1KQ9A 3FMRA 4FO7A 2Q95A 1R58A 2GA2A 4U1BA 4OOKA 1XGSA 3PKDA 2BWXA 4MATA 2BN7A 2GU5A 5JFRA 4U71A 1PV9A 2EA2A 3BIQA 1M35A 4ZWUA 4QR8A 5FCFA 2GU4A 3PKBA 4FO8A 1MATA 1XGOA 4U6JA 2B3LA 4RZZA 5CDVA 2B3KA 2GGCA 1WKMA 2BHBA 3MATA 1XGNA 2V3ZA 3PKCA 4IF7A 1R5HA 3S6BA 2V3YA 2EVMA 1B59A 2BHDA 1WN1A 4U73A 4ZNGA 2V6CA 4U76A 4JUQA 1QXZA 2EA4A 4FLIA 2Q92A 4U69A 1C27A 2BHAA 2IW2A 1C24A 2ADUA 2B3HA 1KQ0A 1YJ3A 2P99A 1C22A 2ZSGA 1WL6A 2NQ6A 1WY2A 5CLSA 3CTZA 1QXWA
chains in the Genus database with same CATH topology
2P98A 1BOAA 4B28A 3PKAA 1WBQA 4PV4A 4FLJA 1BN5A 1C23A 3D27A 2BH3A 1W7VA 1A16A 4HXXA 2GG2A 2MATA 1JAWA 3RVAA 4S2RP 2GG5A 2GG0A 4R60A 4U6EA 1B6AA 4IKTA 4IKRA 2OAZA 4IKUA 3FMQA 4IU6A 1YVMA 1YW7A 1C21A 1R5GA 4FKCA 2EVCA 4IECA 2GG7A 3FM3A 1W2MA 3CB5A 3IU9A 1KP0A 3PKEA 4A6VA 3L7GA 2GU7A 1XGMA 3MX6A 2Q93A 5CNXA 2BWYA 2BWWA 2HOWA 2V3XA 3IG4A 4IPAA 1WL9A 4S2TP 3Q6DA 5CIKA 4FUKA 2GG8A 3TB5A 4EGEA 4U70A 2BWUA 2GGBA 2GTXA 3BITA 1XNZA 5CE6A 3L24A 5JHUA 4U6WA 5E5BA 1YW8A 4S00A 5CDEA 5D6FA 4A6WA 4Z7MA 2GZ5A 2EVOA 2OKNA 1YW9A 5D6EA 2P9AA 5FCHA 4U6CA 2NQ7A 2G6PA 3IU7A 1QZYA 1WLRA 1Y1NA 2BWSA 4ZWOA 2GU6A 2BWVA 4U75A 4KM3A 2BWTA 3MR1A 4RGZ1 4PNCA 1QXYA 3CB6A 2GG3A 4FLLA 1CHMA 5CDLA 2GG9A 3IU8A 2DFIA 2Q96A 4S01A 4IKSA 2Q8KA 4ZWPA 4FLKA 4U6ZA 1N51A 4IDYA 2BB7A 1O0XA 2BHCA 2Q94A 3BIPA 4RZYA 3RORA 3TAVA 5JI6A 1KQ9A 3FMRA 4FO7A 2Q95A 1R58A 2GA2A 4U1BA 4OOKA 1XGSA 3PKDA 2BWXA 4MATA 2BN7A 2GU5A 5JFRA 4U71A 1PV9A 2EA2A 3BIQA 1M35A 4ZWUA 4QR8A 5FCFA 2GU4A 3PKBA 4FO8A 1MATA 1XGOA 4U6JA 2B3LA 4RZZA 5CDVA 2B3KA 2GGCA 1WKMA 2BHBA 3MATA 1XGNA 2V3ZA 3PKCA 4IF7A 1R5HA 3S6BA 2V3YA 2EVMA 1B59A 2BHDA 1WN1A 4U73A 4ZNGA 2V6CA 4U76A 4JUQA 1QXZA 2EA4A 4FLIA 2Q92A 4U69A 1C27A 2BHAA 2IW2A 1C24A 2ADUA 2B3HA 1KQ0A 1YJ3A 2P99A 1C22A 2ZSGA 1WL6A 2NQ6A 1WY2A 5CLSA 3CTZA 1QXWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2P98 A;  1BOA A;  4B28 A;  3PKA A;  1WBQ A;  4PV4 A;  4FLJ A;  1BN5 A;  1C23 A;  3D27 A;  2BH3 A;  1W7V A;  1A16 A;  4HXX A;  2GG2 A;  2MAT A;  1JAW A;  3RVA A;  4S2R P;  2GG5 A;  2GG0 A;  4R60 A;  4U6E A;  1B6A A;  4IKT A;  4IKR A;  2OAZ A;  4IKU A;  3FMQ A;  4IU6 A;  1YVM A;  1YW7 A;  1C21 A;  1R5G A;  4FKC A;  2EVC A;  4IEC A;  2GG7 A;  3FM3 A;  1W2M A;  3CB5 A;  3IU9 A;  1KP0 A;  3PKE A;  4A6V A;  3L7G A;  2GU7 A;  1XGM A;  3MX6 A;  2Q93 A;  5CNX A;  2BWY A;  2BWW A;  2HOW A;  2V3X A;  3IG4 A;  4IPA A;  1WL9 A;  4S2T P;  3Q6D A;  5CIK A;  4FUK A;  2GG8 A;  3TB5 A;  4EGE A;  4U70 A;  2BWU A;  2GGB A;  2GTX A;  3BIT A;  1XNZ A;  5CE6 A;  3L24 A;  5JHU A;  4U6W A;  5E5B A;  1YW8 A;  4S00 A;  5CDE A;  5D6F A;  4A6W A;  4Z7M A;  2GZ5 A;  2EVO A;  2OKN A;  1YW9 A;  5D6E A;  2P9A A;  5FCH A;  4U6C A;  2NQ7 A;  2G6P A;  3IU7 A;  1QZY A;  1WLR A;  1Y1N A;  2BWS A;  4ZWO A;  2GU6 A;  2BWV A;  4U75 A;  4KM3 A;  2BWT A;  3MR1 A;  4RGZ 1;  4PNC A;  1QXY A;  3CB6 A;  2GG3 A;  4FLL A;  1CHM A;  5CDL A;  2GG9 A;  3IU8 A;  2DFI A;  2Q96 A;  4S01 A;  4IKS A;  2Q8K A;  4ZWP A;  4FLK A;  4U6Z A;  1N51 A;  4IDY A;  2BB7 A;  1O0X A;  2BHC A;  2Q94 A;  3BIP A;  4RZY A;  3ROR A;  3TAV A;  5JI6 A;  1KQ9 A;  3FMR A;  4FO7 A;  2Q95 A;  1R58 A;  2GA2 A;  4U1B A;  4OOK A;  1XGS A;  3PKD A;  2BWX A;  4MAT A;  2BN7 A;  2GU5 A;  5JFR A;  4U71 A;  1PV9 A;  2EA2 A;  3BIQ A;  1M35 A;  4ZWU A;  4QR8 A;  5FCF A;  2GU4 A;  3PKB A;  4FO8 A;  1MAT A;  1XGO A;  4U6J A;  2B3L A;  4RZZ A;  5CDV A;  2B3K A;  2GGC A;  1WKM A;  2BHB A;  3MAT A;  1XGN A;  2V3Z A;  3PKC A;  4IF7 A;  1R5H A;  3S6B A;  2V3Y A;  2EVM A;  1B59 A;  2BHD A;  1WN1 A;  4U73 A;  4ZNG A;  2V6C A;  4U76 A;  4JUQ A;  1QXZ A;  2EA4 A;  4FLI A;  2Q92 A;  4U69 A;  1C27 A;  2BHA A;  2IW2 A;  1C24 A;  2ADU A;  2B3H A;  1KQ0 A;  1YJ3 A;  2P99 A;  1C22 A;  2ZSG A;  1WL6 A;  2NQ6 A;  1WY2 A;  5CLS A;  3CTZ A;  1QXW A; 
#chains in the Genus database with same CATH topology
 2P98 A;  1BOA A;  4B28 A;  3PKA A;  1WBQ A;  4PV4 A;  4FLJ A;  1BN5 A;  1C23 A;  3D27 A;  2BH3 A;  1W7V A;  1A16 A;  4HXX A;  2GG2 A;  2MAT A;  1JAW A;  3RVA A;  4S2R P;  2GG5 A;  2GG0 A;  4R60 A;  4U6E A;  1B6A A;  4IKT A;  4IKR A;  2OAZ A;  4IKU A;  3FMQ A;  4IU6 A;  1YVM A;  1YW7 A;  1C21 A;  1R5G A;  4FKC A;  2EVC A;  4IEC A;  2GG7 A;  3FM3 A;  1W2M A;  3CB5 A;  3IU9 A;  1KP0 A;  3PKE A;  4A6V A;  3L7G A;  2GU7 A;  1XGM A;  3MX6 A;  2Q93 A;  5CNX A;  2BWY A;  2BWW A;  2HOW A;  2V3X A;  3IG4 A;  4IPA A;  1WL9 A;  4S2T P;  3Q6D A;  5CIK A;  4FUK A;  2GG8 A;  3TB5 A;  4EGE A;  4U70 A;  2BWU A;  2GGB A;  2GTX A;  3BIT A;  1XNZ A;  5CE6 A;  3L24 A;  5JHU A;  4U6W A;  5E5B A;  1YW8 A;  4S00 A;  5CDE A;  5D6F A;  4A6W A;  4Z7M A;  2GZ5 A;  2EVO A;  2OKN A;  1YW9 A;  5D6E A;  2P9A A;  5FCH A;  4U6C A;  2NQ7 A;  2G6P A;  3IU7 A;  1QZY A;  1WLR A;  1Y1N A;  2BWS A;  4ZWO A;  2GU6 A;  2BWV A;  4U75 A;  4KM3 A;  2BWT A;  3MR1 A;  4RGZ 1;  4PNC A;  1QXY A;  3CB6 A;  2GG3 A;  4FLL A;  1CHM A;  5CDL A;  2GG9 A;  3IU8 A;  2DFI A;  2Q96 A;  4S01 A;  4IKS A;  2Q8K A;  4ZWP A;  4FLK A;  4U6Z A;  1N51 A;  4IDY A;  2BB7 A;  1O0X A;  2BHC A;  2Q94 A;  3BIP A;  4RZY A;  3ROR A;  3TAV A;  5JI6 A;  1KQ9 A;  3FMR A;  4FO7 A;  2Q95 A;  1R58 A;  2GA2 A;  4U1B A;  4OOK A;  1XGS A;  3PKD A;  2BWX A;  4MAT A;  2BN7 A;  2GU5 A;  5JFR A;  4U71 A;  1PV9 A;  2EA2 A;  3BIQ A;  1M35 A;  4ZWU A;  4QR8 A;  5FCF A;  2GU4 A;  3PKB A;  4FO8 A;  1MAT A;  1XGO A;  4U6J A;  2B3L A;  4RZZ A;  5CDV A;  2B3K A;  2GGC A;  1WKM A;  2BHB A;  3MAT A;  1XGN A;  2V3Z A;  3PKC A;  4IF7 A;  1R5H A;  3S6B A;  2V3Y A;  2EVM A;  1B59 A;  2BHD A;  1WN1 A;  4U73 A;  4ZNG A;  2V6C A;  4U76 A;  4JUQ A;  1QXZ A;  2EA4 A;  4FLI A;  2Q92 A;  4U69 A;  1C27 A;  2BHA A;  2IW2 A;  1C24 A;  2ADU A;  2B3H A;  1KQ0 A;  1YJ3 A;  2P99 A;  1C22 A;  2ZSG A;  1WL6 A;  2NQ6 A;  1WY2 A;  5CLS A;  3CTZ A;  1QXW A; 
#chains in the Genus database with same CATH homology
 2P98 A;  1BOA A;  4B28 A;  3PKA A;  1WBQ A;  4PV4 A;  4FLJ A;  1BN5 A;  1C23 A;  3D27 A;  2BH3 A;  1W7V A;  1A16 A;  4HXX A;  2GG2 A;  2MAT A;  1JAW A;  3RVA A;  4S2R P;  2GG5 A;  2GG0 A;  4R60 A;  4U6E A;  1B6A A;  4IKT A;  4IKR A;  2OAZ A;  4IKU A;  3FMQ A;  4IU6 A;  1YVM A;  1YW7 A;  1C21 A;  1R5G A;  4FKC A;  2EVC A;  4IEC A;  2GG7 A;  3FM3 A;  1W2M A;  3CB5 A;  3IU9 A;  1KP0 A;  3PKE A;  4A6V A;  3L7G A;  2GU7 A;  1XGM A;  3MX6 A;  2Q93 A;  5CNX A;  2BWY A;  2BWW A;  2HOW A;  2V3X A;  3IG4 A;  4IPA A;  1WL9 A;  4S2T P;  3Q6D A;  5CIK A;  4FUK A;  2GG8 A;  3TB5 A;  4EGE A;  4U70 A;  2BWU A;  2GGB A;  2GTX A;  3BIT A;  1XNZ A;  5CE6 A;  3L24 A;  5JHU A;  4U6W A;  5E5B A;  1YW8 A;  4S00 A;  5CDE A;  5D6F A;  4A6W A;  4Z7M A;  2GZ5 A;  2EVO A;  2OKN A;  1YW9 A;  5D6E A;  2P9A A;  5FCH A;  4U6C A;  2NQ7 A;  2G6P A;  3IU7 A;  1QZY A;  1WLR A;  1Y1N A;  2BWS A;  4ZWO A;  2GU6 A;  2BWV A;  4U75 A;  4KM3 A;  2BWT A;  3MR1 A;  4RGZ 1;  4PNC A;  1QXY A;  3CB6 A;  2GG3 A;  4FLL A;  1CHM A;  5CDL A;  2GG9 A;  3IU8 A;  2DFI A;  2Q96 A;  4S01 A;  4IKS A;  2Q8K A;  4ZWP A;  4FLK A;  4U6Z A;  1N51 A;  4IDY A;  2BB7 A;  1O0X A;  2BHC A;  2Q94 A;  3BIP A;  4RZY A;  3ROR A;  3TAV A;  5JI6 A;  1KQ9 A;  3FMR A;  4FO7 A;  2Q95 A;  1R58 A;  2GA2 A;  4U1B A;  4OOK A;  1XGS A;  3PKD A;  2BWX A;  4MAT A;  2BN7 A;  2GU5 A;  5JFR A;  4U71 A;  1PV9 A;  2EA2 A;  3BIQ A;  1M35 A;  4ZWU A;  4QR8 A;  5FCF A;  2GU4 A;  3PKB A;  4FO8 A;  1MAT A;  1XGO A;  4U6J A;  2B3L A;  4RZZ A;  5CDV A;  2B3K A;  2GGC A;  1WKM A;  2BHB A;  3MAT A;  1XGN A;  2V3Z A;  3PKC A;  4IF7 A;  1R5H A;  3S6B A;  2V3Y A;  2EVM A;  1B59 A;  2BHD A;  1WN1 A;  4U73 A;  4ZNG A;  2V6C A;  4U76 A;  4JUQ A;  1QXZ A;  2EA4 A;  4FLI A;  2Q92 A;  4U69 A;  1C27 A;  2BHA A;  2IW2 A;  1C24 A;  2ADU A;  2B3H A;  1KQ0 A;  1YJ3 A;  2P99 A;  1C22 A;  2ZSG A;  1WL6 A;  2NQ6 A;  1WY2 A;  5CLS A;  3CTZ A;  1QXW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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