4KM3A

Discovery of a novel structural motif in methionine aminopeptidase from streptococci with possible post-translational modification
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
286
structure length
286
Chain Sequence
b'MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Streptococcus pneumoniae
publication title Discovery of a new genetic variant of methionine aminopeptidase from streptococci with possible post-translational modifications: biochemical and structural characterization.
pubmed doi rcsb
total genus 72
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4km3A00
1W2MA 3D27A 1B59A 4FO8A 1R5GA 2GTXA 1A16A 4S00A 1W7VA 4U6WA 5JFRA 2B3HA 2BWSA 2ADUA 2GU4A 2EA4A 4U75A 2BN7A 1R58A 2GA2A 4ZWOA 3CB6A 2P98A 3FMRA 1WLRA 2GU7A 1BOAA 4IKUA 1C21A 4Z7MA 4B28A 4ZNGA 4RZYA 2GGCA 1XNZA 1YW7A 1WN1A 1O0XA 3MX6A 3PKAA 2BWXA 2ZSGA 4IKTA 4FLLA 3IG4A 2V6CA 4ZWPA 2DFIA 3CTZA 3IU7A 1KQ9A 1BN5A 2P9AA 1QXZA 3L24A 4IKRA 4EGEA 1YW8A 1KQ0A 2MATA 5D6FA 1N51A 2B3LA 4U70A 2V3YA 2BWYA 5CDLA 3MR1A 3Q6DA 2GG5A 5JI6A 4FUKA 4KM3A 2BWWA 1KP0A 2OAZA 2GG7A 4S2RP 5FCFA 3S6BA 1C23A 1YJ3A 3PKEA 1C24A 1JAWA 3IU8A 4FLJA 4JUQA 2BHAA 2Q96A 1XGOA 2Q95A 2GZ5A 4U69A 4IU6A 2BWTA 4U6JA 2BWUA 4FLKA 2GG2A 2Q93A 1MATA 2P99A 1R5HA 1CHMA 2Q8KA 4U71A 1C22A 3FMQA 2NQ7A 5E5BA 5FCHA 2NQ6A 3L7GA 4FLIA 4IECA 4U6ZA 1QXYA 3PKBA 4R60A 3MATA 4U76A 2BWVA 2IW2A 2Q94A 4U1BA 2B3KA 4U73A 2BHCA 2EVOA 1M35A 1XGNA 4IPAA 1QXWA 2EVCA 1WL9A 4IKSA 4RZZA 4OOKA 2BHBA 2V3ZA 5JHUA 4RGZ1 5CLSA 2G6PA 3BIPA 1YW9A 5CDVA 2HOWA 4A6WA 3TB5A 3BIQA 2GG8A 2GU6A 3CB5A 2EA2A 2OKNA 4HXXA 1YVMA 5CIKA 4S2TP 2BB7A 4IDYA 4S01A 4MATA 4U6EA 1WL6A 1B6AA 1QZYA 5CDEA 1WKMA 5D6EA 1WY2A 1WBQA 1PV9A 5CNXA 3RVAA 5CE6A 1XGMA 2V3XA 2BHDA 2GU5A 4QR8A 2Q92A 2EVMA 3BITA 2GG3A 4U6CA 3RORA 1XGSA 3IU9A 3TAVA 2GG0A 4PV4A 4FKCA 3PKCA 4FO7A 4ZWUA 4A6VA 2GG9A 3FM3A 3PKDA 2BH3A 4PNCA 2GGBA 4IF7A 1Y1NA 1C27A
chains in the Genus database with same CATH superfamily
1W2MA 3D27A 1B59A 4FO8A 1R5GA 2GTXA 1A16A 4S00A 1W7VA 4U6WA 5JFRA 2B3HA 2BWSA 2ADUA 2GU4A 2EA4A 4U75A 2BN7A 1R58A 2GA2A 4ZWOA 3CB6A 2P98A 3FMRA 1WLRA 2GU7A 1BOAA 4IKUA 1C21A 4Z7MA 4B28A 4ZNGA 4RZYA 2GGCA 1XNZA 1YW7A 1WN1A 1O0XA 3MX6A 3PKAA 2BWXA 2ZSGA 4IKTA 4FLLA 3IG4A 2V6CA 4ZWPA 2DFIA 3CTZA 3IU7A 1KQ9A 1BN5A 2P9AA 1QXZA 3L24A 4IKRA 4EGEA 1YW8A 1KQ0A 2MATA 5D6FA 1N51A 2B3LA 4U70A 2V3YA 2BWYA 5CDLA 3MR1A 3Q6DA 2GG5A 5JI6A 4FUKA 4KM3A 2BWWA 1KP0A 2OAZA 2GG7A 4S2RP 5FCFA 3S6BA 1C23A 1YJ3A 3PKEA 1C24A 1JAWA 3IU8A 4FLJA 4JUQA 2BHAA 2Q96A 1XGOA 2Q95A 2GZ5A 4U69A 4IU6A 2BWTA 4U6JA 2BWUA 4FLKA 2GG2A 2Q93A 1MATA 2P99A 1R5HA 1CHMA 2Q8KA 4U71A 1C22A 3FMQA 2NQ7A 5E5BA 5FCHA 2NQ6A 3L7GA 4FLIA 4IECA 4U6ZA 1QXYA 3PKBA 4R60A 3MATA 4U76A 2BWVA 2IW2A 2Q94A 4U1BA 2B3KA 4U73A 2BHCA 2EVOA 1M35A 1XGNA 4IPAA 1QXWA 2EVCA 1WL9A 4IKSA 4RZZA 4OOKA 2BHBA 2V3ZA 5JHUA 4RGZ1 5CLSA 2G6PA 3BIPA 1YW9A 5CDVA 2HOWA 4A6WA 3TB5A 3BIQA 2GG8A 2GU6A 3CB5A 2EA2A 2OKNA 4HXXA 1YVMA 5CIKA 4S2TP 2BB7A 4IDYA 4S01A 4MATA 4U6EA 1WL6A 1B6AA 1QZYA 5CDEA 1WKMA 5D6EA 1WY2A 1WBQA 1PV9A 5CNXA 3RVAA 5CE6A 1XGMA 2V3XA 2BHDA 2GU5A 4QR8A 2Q92A 2EVMA 3BITA 2GG3A 4U6CA 3RORA 1XGSA 3IU9A 3TAVA 2GG0A 4PV4A 4FKCA 3PKCA 4FO7A 4ZWUA 4A6VA 2GG9A 3FM3A 3PKDA 2BH3A 4PNCA 2GGBA 4IF7A 1Y1NA 1C27A
chains in the Genus database with same CATH topology
1W2MA 3D27A 1B59A 4FO8A 1R5GA 2GTXA 1A16A 4S00A 1W7VA 4U6WA 5JFRA 2B3HA 2BWSA 2ADUA 2GU4A 2EA4A 4U75A 2BN7A 1R58A 2GA2A 4ZWOA 3CB6A 2P98A 3FMRA 1WLRA 2GU7A 1BOAA 4IKUA 1C21A 4Z7MA 4B28A 4ZNGA 4RZYA 2GGCA 1XNZA 1YW7A 1WN1A 1O0XA 3MX6A 3PKAA 2BWXA 2ZSGA 4IKTA 4FLLA 3IG4A 2V6CA 4ZWPA 2DFIA 3CTZA 3IU7A 1KQ9A 1BN5A 2P9AA 1QXZA 3L24A 4IKRA 4EGEA 1YW8A 1KQ0A 2MATA 5D6FA 1N51A 2B3LA 4U70A 2V3YA 2BWYA 5CDLA 3MR1A 3Q6DA 2GG5A 5JI6A 4FUKA 4KM3A 2BWWA 1KP0A 2OAZA 2GG7A 4S2RP 5FCFA 3S6BA 1C23A 1YJ3A 3PKEA 1C24A 1JAWA 3IU8A 4FLJA 4JUQA 2BHAA 2Q96A 1XGOA 2Q95A 2GZ5A 4U69A 4IU6A 2BWTA 4U6JA 2BWUA 4FLKA 2GG2A 2Q93A 1MATA 2P99A 1R5HA 1CHMA 2Q8KA 4U71A 1C22A 3FMQA 2NQ7A 5E5BA 5FCHA 2NQ6A 3L7GA 4FLIA 4IECA 4U6ZA 1QXYA 3PKBA 4R60A 3MATA 4U76A 2BWVA 2IW2A 2Q94A 4U1BA 2B3KA 4U73A 2BHCA 2EVOA 1M35A 1XGNA 4IPAA 1QXWA 2EVCA 1WL9A 4IKSA 4RZZA 4OOKA 2BHBA 2V3ZA 5JHUA 4RGZ1 5CLSA 2G6PA 3BIPA 1YW9A 5CDVA 2HOWA 4A6WA 3TB5A 3BIQA 2GG8A 2GU6A 3CB5A 2EA2A 2OKNA 4HXXA 1YVMA 5CIKA 4S2TP 2BB7A 4IDYA 4S01A 4MATA 4U6EA 1WL6A 1B6AA 1QZYA 5CDEA 1WKMA 5D6EA 1WY2A 1WBQA 1PV9A 5CNXA 3RVAA 5CE6A 1XGMA 2V3XA 2BHDA 2GU5A 4QR8A 2Q92A 2EVMA 3BITA 2GG3A 4U6CA 3RORA 1XGSA 3IU9A 3TAVA 2GG0A 4PV4A 4FKCA 3PKCA 4FO7A 4ZWUA 4A6VA 2GG9A 3FM3A 3PKDA 2BH3A 4PNCA 2GGBA 4IF7A 1Y1NA 1C27A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1W2M A;  3D27 A;  1B59 A;  4FO8 A;  1R5G A;  2GTX A;  1A16 A;  4S00 A;  1W7V A;  4U6W A;  5JFR A;  2B3H A;  2BWS A;  2ADU A;  2GU4 A;  2EA4 A;  4U75 A;  2BN7 A;  1R58 A;  2GA2 A;  4ZWO A;  3CB6 A;  2P98 A;  3FMR A;  1WLR A;  2GU7 A;  1BOA A;  4IKU A;  1C21 A;  4Z7M A;  4B28 A;  4ZNG A;  4RZY A;  2GGC A;  1XNZ A;  1YW7 A;  1WN1 A;  1O0X A;  3MX6 A;  3PKA A;  2BWX A;  2ZSG A;  4IKT A;  4FLL A;  3IG4 A;  2V6C A;  4ZWP A;  2DFI A;  3CTZ A;  3IU7 A;  1KQ9 A;  1BN5 A;  2P9A A;  1QXZ A;  3L24 A;  4IKR A;  4EGE A;  1YW8 A;  1KQ0 A;  2MAT A;  5D6F A;  1N51 A;  2B3L A;  4U70 A;  2V3Y A;  2BWY A;  5CDL A;  3MR1 A;  3Q6D A;  2GG5 A;  5JI6 A;  4FUK A;  4KM3 A;  2BWW A;  1KP0 A;  2OAZ A;  2GG7 A;  4S2R P;  5FCF A;  3S6B A;  1C23 A;  1YJ3 A;  3PKE A;  1C24 A;  1JAW A;  3IU8 A;  4FLJ A;  4JUQ A;  2BHA A;  2Q96 A;  1XGO A;  2Q95 A;  2GZ5 A;  4U69 A;  4IU6 A;  2BWT A;  4U6J A;  2BWU A;  4FLK A;  2GG2 A;  2Q93 A;  1MAT A;  2P99 A;  1R5H A;  1CHM A;  2Q8K A;  4U71 A;  1C22 A;  3FMQ A;  2NQ7 A;  5E5B A;  5FCH A;  2NQ6 A;  3L7G A;  4FLI A;  4IEC A;  4U6Z A;  1QXY A;  3PKB A;  4R60 A;  3MAT A;  4U76 A;  2BWV A;  2IW2 A;  2Q94 A;  4U1B A;  2B3K A;  4U73 A;  2BHC A;  2EVO A;  1M35 A;  1XGN A;  4IPA A;  1QXW A;  2EVC A;  1WL9 A;  4IKS A;  4RZZ A;  4OOK A;  2BHB A;  2V3Z A;  5JHU A;  4RGZ 1;  5CLS A;  2G6P A;  3BIP A;  1YW9 A;  5CDV A;  2HOW A;  4A6W A;  3TB5 A;  3BIQ A;  2GG8 A;  2GU6 A;  3CB5 A;  2EA2 A;  2OKN A;  4HXX A;  1YVM A;  5CIK A;  4S2T P;  2BB7 A;  4IDY A;  4S01 A;  4MAT A;  4U6E A;  1WL6 A;  1B6A A;  1QZY A;  5CDE A;  1WKM A;  5D6E A;  1WY2 A;  1WBQ A;  1PV9 A;  5CNX A;  3RVA A;  5CE6 A;  1XGM A;  2V3X A;  2BHD A;  2GU5 A;  4QR8 A;  2Q92 A;  2EVM A;  3BIT A;  2GG3 A;  4U6C A;  3ROR A;  1XGS A;  3IU9 A;  3TAV A;  2GG0 A;  4PV4 A;  4FKC A;  3PKC A;  4FO7 A;  4ZWU A;  4A6V A;  2GG9 A;  3FM3 A;  3PKD A;  2BH3 A;  4PNC A;  2GGB A;  4IF7 A;  1Y1N A;  1C27 A; 
#chains in the Genus database with same CATH topology
 1W2M A;  3D27 A;  1B59 A;  4FO8 A;  1R5G A;  2GTX A;  1A16 A;  4S00 A;  1W7V A;  4U6W A;  5JFR A;  2B3H A;  2BWS A;  2ADU A;  2GU4 A;  2EA4 A;  4U75 A;  2BN7 A;  1R58 A;  2GA2 A;  4ZWO A;  3CB6 A;  2P98 A;  3FMR A;  1WLR A;  2GU7 A;  1BOA A;  4IKU A;  1C21 A;  4Z7M A;  4B28 A;  4ZNG A;  4RZY A;  2GGC A;  1XNZ A;  1YW7 A;  1WN1 A;  1O0X A;  3MX6 A;  3PKA A;  2BWX A;  2ZSG A;  4IKT A;  4FLL A;  3IG4 A;  2V6C A;  4ZWP A;  2DFI A;  3CTZ A;  3IU7 A;  1KQ9 A;  1BN5 A;  2P9A A;  1QXZ A;  3L24 A;  4IKR A;  4EGE A;  1YW8 A;  1KQ0 A;  2MAT A;  5D6F A;  1N51 A;  2B3L A;  4U70 A;  2V3Y A;  2BWY A;  5CDL A;  3MR1 A;  3Q6D A;  2GG5 A;  5JI6 A;  4FUK A;  4KM3 A;  2BWW A;  1KP0 A;  2OAZ A;  2GG7 A;  4S2R P;  5FCF A;  3S6B A;  1C23 A;  1YJ3 A;  3PKE A;  1C24 A;  1JAW A;  3IU8 A;  4FLJ A;  4JUQ A;  2BHA A;  2Q96 A;  1XGO A;  2Q95 A;  2GZ5 A;  4U69 A;  4IU6 A;  2BWT A;  4U6J A;  2BWU A;  4FLK A;  2GG2 A;  2Q93 A;  1MAT A;  2P99 A;  1R5H A;  1CHM A;  2Q8K A;  4U71 A;  1C22 A;  3FMQ A;  2NQ7 A;  5E5B A;  5FCH A;  2NQ6 A;  3L7G A;  4FLI A;  4IEC A;  4U6Z A;  1QXY A;  3PKB A;  4R60 A;  3MAT A;  4U76 A;  2BWV A;  2IW2 A;  2Q94 A;  4U1B A;  2B3K A;  4U73 A;  2BHC A;  2EVO A;  1M35 A;  1XGN A;  4IPA A;  1QXW A;  2EVC A;  1WL9 A;  4IKS A;  4RZZ A;  4OOK A;  2BHB A;  2V3Z A;  5JHU A;  4RGZ 1;  5CLS A;  2G6P A;  3BIP A;  1YW9 A;  5CDV A;  2HOW A;  4A6W A;  3TB5 A;  3BIQ A;  2GG8 A;  2GU6 A;  3CB5 A;  2EA2 A;  2OKN A;  4HXX A;  1YVM A;  5CIK A;  4S2T P;  2BB7 A;  4IDY A;  4S01 A;  4MAT A;  4U6E A;  1WL6 A;  1B6A A;  1QZY A;  5CDE A;  1WKM A;  5D6E A;  1WY2 A;  1WBQ A;  1PV9 A;  5CNX A;  3RVA A;  5CE6 A;  1XGM A;  2V3X A;  2BHD A;  2GU5 A;  4QR8 A;  2Q92 A;  2EVM A;  3BIT A;  2GG3 A;  4U6C A;  3ROR A;  1XGS A;  3IU9 A;  3TAV A;  2GG0 A;  4PV4 A;  4FKC A;  3PKC A;  4FO7 A;  4ZWU A;  4A6V A;  2GG9 A;  3FM3 A;  3PKD A;  2BH3 A;  4PNC A;  2GGB A;  4IF7 A;  1Y1N A;  1C27 A; 
#chains in the Genus database with same CATH homology
 1W2M A;  3D27 A;  1B59 A;  4FO8 A;  1R5G A;  2GTX A;  1A16 A;  4S00 A;  1W7V A;  4U6W A;  5JFR A;  2B3H A;  2BWS A;  2ADU A;  2GU4 A;  2EA4 A;  4U75 A;  2BN7 A;  1R58 A;  2GA2 A;  4ZWO A;  3CB6 A;  2P98 A;  3FMR A;  1WLR A;  2GU7 A;  1BOA A;  4IKU A;  1C21 A;  4Z7M A;  4B28 A;  4ZNG A;  4RZY A;  2GGC A;  1XNZ A;  1YW7 A;  1WN1 A;  1O0X A;  3MX6 A;  3PKA A;  2BWX A;  2ZSG A;  4IKT A;  4FLL A;  3IG4 A;  2V6C A;  4ZWP A;  2DFI A;  3CTZ A;  3IU7 A;  1KQ9 A;  1BN5 A;  2P9A A;  1QXZ A;  3L24 A;  4IKR A;  4EGE A;  1YW8 A;  1KQ0 A;  2MAT A;  5D6F A;  1N51 A;  2B3L A;  4U70 A;  2V3Y A;  2BWY A;  5CDL A;  3MR1 A;  3Q6D A;  2GG5 A;  5JI6 A;  4FUK A;  4KM3 A;  2BWW A;  1KP0 A;  2OAZ A;  2GG7 A;  4S2R P;  5FCF A;  3S6B A;  1C23 A;  1YJ3 A;  3PKE A;  1C24 A;  1JAW A;  3IU8 A;  4FLJ A;  4JUQ A;  2BHA A;  2Q96 A;  1XGO A;  2Q95 A;  2GZ5 A;  4U69 A;  4IU6 A;  2BWT A;  4U6J A;  2BWU A;  4FLK A;  2GG2 A;  2Q93 A;  1MAT A;  2P99 A;  1R5H A;  1CHM A;  2Q8K A;  4U71 A;  1C22 A;  3FMQ A;  2NQ7 A;  5E5B A;  5FCH A;  2NQ6 A;  3L7G A;  4FLI A;  4IEC A;  4U6Z A;  1QXY A;  3PKB A;  4R60 A;  3MAT A;  4U76 A;  2BWV A;  2IW2 A;  2Q94 A;  4U1B A;  2B3K A;  4U73 A;  2BHC A;  2EVO A;  1M35 A;  1XGN A;  4IPA A;  1QXW A;  2EVC A;  1WL9 A;  4IKS A;  4RZZ A;  4OOK A;  2BHB A;  2V3Z A;  5JHU A;  4RGZ 1;  5CLS A;  2G6P A;  3BIP A;  1YW9 A;  5CDV A;  2HOW A;  4A6W A;  3TB5 A;  3BIQ A;  2GG8 A;  2GU6 A;  3CB5 A;  2EA2 A;  2OKN A;  4HXX A;  1YVM A;  5CIK A;  4S2T P;  2BB7 A;  4IDY A;  4S01 A;  4MAT A;  4U6E A;  1WL6 A;  1B6A A;  1QZY A;  5CDE A;  1WKM A;  5D6E A;  1WY2 A;  1WBQ A;  1PV9 A;  5CNX A;  3RVA A;  5CE6 A;  1XGM A;  2V3X A;  2BHD A;  2GU5 A;  4QR8 A;  2Q92 A;  2EVM A;  3BIT A;  2GG3 A;  4U6C A;  3ROR A;  1XGS A;  3IU9 A;  3TAV A;  2GG0 A;  4PV4 A;  4FKC A;  3PKC A;  4FO7 A;  4ZWU A;  4A6V A;  2GG9 A;  3FM3 A;  3PKD A;  2BH3 A;  4PNC A;  2GGB A;  4IF7 A;  1Y1N A;  1C27 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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