4IF7A

Mycobacterium tuberculosis methionine aminopeptidase type 1c in complex with homocysteine-methyl disulfide
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
281
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
total genus 86
structure length 281
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4if7A01
4S01A 3IG4A 2BHBA 3Q6DA 3PKCA 5CDEA 1JAWA 3FMQA 4HXXA 1QZYA 5D6EA 3PKDA 4ZWPA 1WKMA 2BWVA 4A6WA 4IECA 3TAVA 3D27A 1KP0A 5CDVA 2BWXA 4EGEA 1R58A 4RGZ1 1PV9A 3PKEA 4JUQA 3IU8A 1XGMA 1WBQA 2NQ7A 2BWWA 3BIPA 5CNXA 4U69A 4FKCA 2GG7A 1WN1A 4FO8A 1A16A 3PKAA 4U71A 2P99A 4IPAA 2Q96A 4PV4A 2GG5A 3FM3A 4U75A 1YW7A 2NQ6A 2V6CA 1YJ3A 2GG8A 2IW2A 4IKSA 3BIQA 5CE6A 2GGCA 1W2MA 4ZWUA 2GU7A 2HOWA 1C24A 1QXZA 2DFIA 2EVMA 2EA4A 3FMRA 2BWUA 1WL6A 2G6PA 1KQ9A 2Q8KA 3MATA 3MX6A 4IU6A 2BN7A 1XGSA 2ZSGA 2EVCA 4OOKA 1N51A 4IKUA 1WY2A 4PNCA 1Y1NA 4FLJA 1O0XA 1C22A 2BWYA 2GG9A 1YW9A 1R5GA 3IU7A 4FLLA 5JHUA 4FLKA 2GZ5A 2B3HA 2P9AA 2V3XA 2MATA 5CDLA 5D6FA 2BHDA 2P98A 2Q92A 4U73A 1QXYA 1XGNA 2EVOA 5CIKA 2BWTA 2GTXA 2B3LA 4U76A 1WLRA 1C27A 5CLSA 4ZWOA 3IU9A 1MATA 4RZYA 4KM3A 2B3KA 2BB7A 4A6VA 2OAZA 5JFRA 1BOAA 4U6CA 4U6ZA 4S2RP 1QXWA 2BHAA 4MATA 3PKBA 1W7VA 4R60A 4U6EA 3TB5A 1C21A 1WL9A 1YVMA 4RZZA 2BH3A 5FCFA 1B6AA 2BWSA 4Z7MA 2GG0A 4ZNGA 3RORA 5FCHA 4FUKA 2GU5A 3CTZA 4IKTA 2GU4A 1YW8A 3L7GA 5E5BA 2GGBA 4U6WA 1XGOA 4IDYA 4S2TP 2Q94A 4U6JA 1BN5A 4IKRA 4S00A 1XNZA 4U1BA 4B28A 4U70A 2GA2A 2GG3A 2ADUA 1M35A 3BITA 2Q93A 2Q95A 3CB5A 2BHCA 3MR1A 3RVAA 2OKNA 1KQ0A 4IF7A 1R5HA 3L24A 3CB6A 2GU6A 1C23A 3S6BA 4FLIA 1B59A 2EA2A 2V3ZA 1CHMA 2GG2A 4FO7A 4QR8A 5JI6A 2V3YA
chains in the Genus database with same CATH superfamily
4S01A 3IG4A 2BHBA 3Q6DA 3PKCA 5CDEA 1JAWA 3FMQA 4HXXA 1QZYA 5D6EA 3PKDA 4ZWPA 1WKMA 2BWVA 4A6WA 4IECA 3TAVA 3D27A 1KP0A 5CDVA 2BWXA 4EGEA 1R58A 4RGZ1 1PV9A 3PKEA 4JUQA 3IU8A 1XGMA 1WBQA 2NQ7A 2BWWA 3BIPA 5CNXA 4U69A 4FKCA 2GG7A 1WN1A 4FO8A 1A16A 3PKAA 4U71A 2P99A 4IPAA 2Q96A 4PV4A 2GG5A 3FM3A 4U75A 1YW7A 2NQ6A 2V6CA 1YJ3A 2GG8A 2IW2A 4IKSA 3BIQA 5CE6A 2GGCA 1W2MA 4ZWUA 2GU7A 2HOWA 1C24A 1QXZA 2DFIA 2EVMA 2EA4A 3FMRA 2BWUA 1WL6A 2G6PA 1KQ9A 2Q8KA 3MATA 3MX6A 4IU6A 2BN7A 1XGSA 2ZSGA 2EVCA 4OOKA 1N51A 4IKUA 1WY2A 4PNCA 1Y1NA 4FLJA 1O0XA 1C22A 2BWYA 2GG9A 1YW9A 1R5GA 3IU7A 4FLLA 5JHUA 4FLKA 2GZ5A 2B3HA 2P9AA 2V3XA 2MATA 5CDLA 5D6FA 2BHDA 2P98A 2Q92A 4U73A 1QXYA 1XGNA 2EVOA 5CIKA 2BWTA 2GTXA 2B3LA 4U76A 1WLRA 1C27A 5CLSA 4ZWOA 3IU9A 1MATA 4RZYA 4KM3A 2B3KA 2BB7A 4A6VA 2OAZA 5JFRA 1BOAA 4U6CA 4U6ZA 4S2RP 1QXWA 2BHAA 4MATA 3PKBA 1W7VA 4R60A 4U6EA 3TB5A 1C21A 1WL9A 1YVMA 4RZZA 2BH3A 5FCFA 1B6AA 2BWSA 4Z7MA 2GG0A 4ZNGA 3RORA 5FCHA 4FUKA 2GU5A 3CTZA 4IKTA 2GU4A 1YW8A 3L7GA 5E5BA 2GGBA 4U6WA 1XGOA 4IDYA 4S2TP 2Q94A 4U6JA 1BN5A 4IKRA 4S00A 1XNZA 4U1BA 4B28A 4U70A 2GA2A 2GG3A 2ADUA 1M35A 3BITA 2Q93A 2Q95A 3CB5A 2BHCA 3MR1A 3RVAA 2OKNA 1KQ0A 4IF7A 1R5HA 3L24A 3CB6A 2GU6A 1C23A 3S6BA 4FLIA 1B59A 2EA2A 2V3ZA 1CHMA 2GG2A 4FO7A 4QR8A 5JI6A 2V3YA
chains in the Genus database with same CATH topology
4S01A 3IG4A 2BHBA 3Q6DA 3PKCA 5CDEA 1JAWA 3FMQA 4HXXA 1QZYA 5D6EA 3PKDA 4ZWPA 1WKMA 2BWVA 4A6WA 4IECA 3TAVA 3D27A 1KP0A 5CDVA 2BWXA 4EGEA 1R58A 4RGZ1 1PV9A 3PKEA 4JUQA 3IU8A 1XGMA 1WBQA 2NQ7A 2BWWA 3BIPA 5CNXA 4U69A 4FKCA 2GG7A 1WN1A 4FO8A 1A16A 3PKAA 4U71A 2P99A 4IPAA 2Q96A 4PV4A 2GG5A 3FM3A 4U75A 1YW7A 2NQ6A 2V6CA 1YJ3A 2GG8A 2IW2A 4IKSA 3BIQA 5CE6A 2GGCA 1W2MA 4ZWUA 2GU7A 2HOWA 1C24A 1QXZA 2DFIA 2EVMA 2EA4A 3FMRA 2BWUA 1WL6A 2G6PA 1KQ9A 2Q8KA 3MATA 3MX6A 4IU6A 2BN7A 1XGSA 2ZSGA 2EVCA 4OOKA 1N51A 4IKUA 1WY2A 4PNCA 1Y1NA 4FLJA 1O0XA 1C22A 2BWYA 2GG9A 1YW9A 1R5GA 3IU7A 4FLLA 5JHUA 4FLKA 2GZ5A 2B3HA 2P9AA 2V3XA 2MATA 5CDLA 5D6FA 2BHDA 2P98A 2Q92A 4U73A 1QXYA 1XGNA 2EVOA 5CIKA 2BWTA 2GTXA 2B3LA 4U76A 1WLRA 1C27A 5CLSA 4ZWOA 3IU9A 1MATA 4RZYA 4KM3A 2B3KA 2BB7A 4A6VA 2OAZA 5JFRA 1BOAA 4U6CA 4U6ZA 4S2RP 1QXWA 2BHAA 4MATA 3PKBA 1W7VA 4R60A 4U6EA 3TB5A 1C21A 1WL9A 1YVMA 4RZZA 2BH3A 5FCFA 1B6AA 2BWSA 4Z7MA 2GG0A 4ZNGA 3RORA 5FCHA 4FUKA 2GU5A 3CTZA 4IKTA 2GU4A 1YW8A 3L7GA 5E5BA 2GGBA 4U6WA 1XGOA 4IDYA 4S2TP 2Q94A 4U6JA 1BN5A 4IKRA 4S00A 1XNZA 4U1BA 4B28A 4U70A 2GA2A 2GG3A 2ADUA 1M35A 3BITA 2Q93A 2Q95A 3CB5A 2BHCA 3MR1A 3RVAA 2OKNA 1KQ0A 4IF7A 1R5HA 3L24A 3CB6A 2GU6A 1C23A 3S6BA 4FLIA 1B59A 2EA2A 2V3ZA 1CHMA 2GG2A 4FO7A 4QR8A 5JI6A 2V3YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4S01 A;  3IG4 A;  2BHB A;  3Q6D A;  3PKC A;  5CDE A;  1JAW A;  3FMQ A;  4HXX A;  1QZY A;  5D6E A;  3PKD A;  4ZWP A;  1WKM A;  2BWV A;  4A6W A;  4IEC A;  3TAV A;  3D27 A;  1KP0 A;  5CDV A;  2BWX A;  4EGE A;  1R58 A;  4RGZ 1;  1PV9 A;  3PKE A;  4JUQ A;  3IU8 A;  1XGM A;  1WBQ A;  2NQ7 A;  2BWW A;  3BIP A;  5CNX A;  4U69 A;  4FKC A;  2GG7 A;  1WN1 A;  4FO8 A;  1A16 A;  3PKA A;  4U71 A;  2P99 A;  4IPA A;  2Q96 A;  4PV4 A;  2GG5 A;  3FM3 A;  4U75 A;  1YW7 A;  2NQ6 A;  2V6C A;  1YJ3 A;  2GG8 A;  2IW2 A;  4IKS A;  3BIQ A;  5CE6 A;  2GGC A;  1W2M A;  4ZWU A;  2GU7 A;  2HOW A;  1C24 A;  1QXZ A;  2DFI A;  2EVM A;  2EA4 A;  3FMR A;  2BWU A;  1WL6 A;  2G6P A;  1KQ9 A;  2Q8K A;  3MAT A;  3MX6 A;  4IU6 A;  2BN7 A;  1XGS A;  2ZSG A;  2EVC A;  4OOK A;  1N51 A;  4IKU A;  1WY2 A;  4PNC A;  1Y1N A;  4FLJ A;  1O0X A;  1C22 A;  2BWY A;  2GG9 A;  1YW9 A;  1R5G A;  3IU7 A;  4FLL A;  5JHU A;  4FLK A;  2GZ5 A;  2B3H A;  2P9A A;  2V3X A;  2MAT A;  5CDL A;  5D6F A;  2BHD A;  2P98 A;  2Q92 A;  4U73 A;  1QXY A;  1XGN A;  2EVO A;  5CIK A;  2BWT A;  2GTX A;  2B3L A;  4U76 A;  1WLR A;  1C27 A;  5CLS A;  4ZWO A;  3IU9 A;  1MAT A;  4RZY A;  4KM3 A;  2B3K A;  2BB7 A;  4A6V A;  2OAZ A;  5JFR A;  1BOA A;  4U6C A;  4U6Z A;  4S2R P;  1QXW A;  2BHA A;  4MAT A;  3PKB A;  1W7V A;  4R60 A;  4U6E A;  3TB5 A;  1C21 A;  1WL9 A;  1YVM A;  4RZZ A;  2BH3 A;  5FCF A;  1B6A A;  2BWS A;  4Z7M A;  2GG0 A;  4ZNG A;  3ROR A;  5FCH A;  4FUK A;  2GU5 A;  3CTZ A;  4IKT A;  2GU4 A;  1YW8 A;  3L7G A;  5E5B A;  2GGB A;  4U6W A;  1XGO A;  4IDY A;  4S2T P;  2Q94 A;  4U6J A;  1BN5 A;  4IKR A;  4S00 A;  1XNZ A;  4U1B A;  4B28 A;  4U70 A;  2GA2 A;  2GG3 A;  2ADU A;  1M35 A;  3BIT A;  2Q93 A;  2Q95 A;  3CB5 A;  2BHC A;  3MR1 A;  3RVA A;  2OKN A;  1KQ0 A;  4IF7 A;  1R5H A;  3L24 A;  3CB6 A;  2GU6 A;  1C23 A;  3S6B A;  4FLI A;  1B59 A;  2EA2 A;  2V3Z A;  1CHM A;  2GG2 A;  4FO7 A;  4QR8 A;  5JI6 A;  2V3Y A; 
#chains in the Genus database with same CATH topology
 4S01 A;  3IG4 A;  2BHB A;  3Q6D A;  3PKC A;  5CDE A;  1JAW A;  3FMQ A;  4HXX A;  1QZY A;  5D6E A;  3PKD A;  4ZWP A;  1WKM A;  2BWV A;  4A6W A;  4IEC A;  3TAV A;  3D27 A;  1KP0 A;  5CDV A;  2BWX A;  4EGE A;  1R58 A;  4RGZ 1;  1PV9 A;  3PKE A;  4JUQ A;  3IU8 A;  1XGM A;  1WBQ A;  2NQ7 A;  2BWW A;  3BIP A;  5CNX A;  4U69 A;  4FKC A;  2GG7 A;  1WN1 A;  4FO8 A;  1A16 A;  3PKA A;  4U71 A;  2P99 A;  4IPA A;  2Q96 A;  4PV4 A;  2GG5 A;  3FM3 A;  4U75 A;  1YW7 A;  2NQ6 A;  2V6C A;  1YJ3 A;  2GG8 A;  2IW2 A;  4IKS A;  3BIQ A;  5CE6 A;  2GGC A;  1W2M A;  4ZWU A;  2GU7 A;  2HOW A;  1C24 A;  1QXZ A;  2DFI A;  2EVM A;  2EA4 A;  3FMR A;  2BWU A;  1WL6 A;  2G6P A;  1KQ9 A;  2Q8K A;  3MAT A;  3MX6 A;  4IU6 A;  2BN7 A;  1XGS A;  2ZSG A;  2EVC A;  4OOK A;  1N51 A;  4IKU A;  1WY2 A;  4PNC A;  1Y1N A;  4FLJ A;  1O0X A;  1C22 A;  2BWY A;  2GG9 A;  1YW9 A;  1R5G A;  3IU7 A;  4FLL A;  5JHU A;  4FLK A;  2GZ5 A;  2B3H A;  2P9A A;  2V3X A;  2MAT A;  5CDL A;  5D6F A;  2BHD A;  2P98 A;  2Q92 A;  4U73 A;  1QXY A;  1XGN A;  2EVO A;  5CIK A;  2BWT A;  2GTX A;  2B3L A;  4U76 A;  1WLR A;  1C27 A;  5CLS A;  4ZWO A;  3IU9 A;  1MAT A;  4RZY A;  4KM3 A;  2B3K A;  2BB7 A;  4A6V A;  2OAZ A;  5JFR A;  1BOA A;  4U6C A;  4U6Z A;  4S2R P;  1QXW A;  2BHA A;  4MAT A;  3PKB A;  1W7V A;  4R60 A;  4U6E A;  3TB5 A;  1C21 A;  1WL9 A;  1YVM A;  4RZZ A;  2BH3 A;  5FCF A;  1B6A A;  2BWS A;  4Z7M A;  2GG0 A;  4ZNG A;  3ROR A;  5FCH A;  4FUK A;  2GU5 A;  3CTZ A;  4IKT A;  2GU4 A;  1YW8 A;  3L7G A;  5E5B A;  2GGB A;  4U6W A;  1XGO A;  4IDY A;  4S2T P;  2Q94 A;  4U6J A;  1BN5 A;  4IKR A;  4S00 A;  1XNZ A;  4U1B A;  4B28 A;  4U70 A;  2GA2 A;  2GG3 A;  2ADU A;  1M35 A;  3BIT A;  2Q93 A;  2Q95 A;  3CB5 A;  2BHC A;  3MR1 A;  3RVA A;  2OKN A;  1KQ0 A;  4IF7 A;  1R5H A;  3L24 A;  3CB6 A;  2GU6 A;  1C23 A;  3S6B A;  4FLI A;  1B59 A;  2EA2 A;  2V3Z A;  1CHM A;  2GG2 A;  4FO7 A;  4QR8 A;  5JI6 A;  2V3Y A; 
#chains in the Genus database with same CATH homology
 4S01 A;  3IG4 A;  2BHB A;  3Q6D A;  3PKC A;  5CDE A;  1JAW A;  3FMQ A;  4HXX A;  1QZY A;  5D6E A;  3PKD A;  4ZWP A;  1WKM A;  2BWV A;  4A6W A;  4IEC A;  3TAV A;  3D27 A;  1KP0 A;  5CDV A;  2BWX A;  4EGE A;  1R58 A;  4RGZ 1;  1PV9 A;  3PKE A;  4JUQ A;  3IU8 A;  1XGM A;  1WBQ A;  2NQ7 A;  2BWW A;  3BIP A;  5CNX A;  4U69 A;  4FKC A;  2GG7 A;  1WN1 A;  4FO8 A;  1A16 A;  3PKA A;  4U71 A;  2P99 A;  4IPA A;  2Q96 A;  4PV4 A;  2GG5 A;  3FM3 A;  4U75 A;  1YW7 A;  2NQ6 A;  2V6C A;  1YJ3 A;  2GG8 A;  2IW2 A;  4IKS A;  3BIQ A;  5CE6 A;  2GGC A;  1W2M A;  4ZWU A;  2GU7 A;  2HOW A;  1C24 A;  1QXZ A;  2DFI A;  2EVM A;  2EA4 A;  3FMR A;  2BWU A;  1WL6 A;  2G6P A;  1KQ9 A;  2Q8K A;  3MAT A;  3MX6 A;  4IU6 A;  2BN7 A;  1XGS A;  2ZSG A;  2EVC A;  4OOK A;  1N51 A;  4IKU A;  1WY2 A;  4PNC A;  1Y1N A;  4FLJ A;  1O0X A;  1C22 A;  2BWY A;  2GG9 A;  1YW9 A;  1R5G A;  3IU7 A;  4FLL A;  5JHU A;  4FLK A;  2GZ5 A;  2B3H A;  2P9A A;  2V3X A;  2MAT A;  5CDL A;  5D6F A;  2BHD A;  2P98 A;  2Q92 A;  4U73 A;  1QXY A;  1XGN A;  2EVO A;  5CIK A;  2BWT A;  2GTX A;  2B3L A;  4U76 A;  1WLR A;  1C27 A;  5CLS A;  4ZWO A;  3IU9 A;  1MAT A;  4RZY A;  4KM3 A;  2B3K A;  2BB7 A;  4A6V A;  2OAZ A;  5JFR A;  1BOA A;  4U6C A;  4U6Z A;  4S2R P;  1QXW A;  2BHA A;  4MAT A;  3PKB A;  1W7V A;  4R60 A;  4U6E A;  3TB5 A;  1C21 A;  1WL9 A;  1YVM A;  4RZZ A;  2BH3 A;  5FCF A;  1B6A A;  2BWS A;  4Z7M A;  2GG0 A;  4ZNG A;  3ROR A;  5FCH A;  4FUK A;  2GU5 A;  3CTZ A;  4IKT A;  2GU4 A;  1YW8 A;  3L7G A;  5E5B A;  2GGB A;  4U6W A;  1XGO A;  4IDY A;  4S2T P;  2Q94 A;  4U6J A;  1BN5 A;  4IKR A;  4S00 A;  1XNZ A;  4U1B A;  4B28 A;  4U70 A;  2GA2 A;  2GG3 A;  2ADU A;  1M35 A;  3BIT A;  2Q93 A;  2Q95 A;  3CB5 A;  2BHC A;  3MR1 A;  3RVA A;  2OKN A;  1KQ0 A;  4IF7 A;  1R5H A;  3L24 A;  3CB6 A;  2GU6 A;  1C23 A;  3S6B A;  4FLI A;  1B59 A;  2EA2 A;  2V3Z A;  1CHM A;  2GG2 A;  4FO7 A;  4QR8 A;  5JI6 A;  2V3Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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