4IF7A

Mycobacterium tuberculosis methionine aminopeptidase type 1c in complex with homocysteine-methyl disulfide
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
281
Chain Sequence
b'RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Methionine aminopeptidase 2
molecule tags Hydrolase
source organism Mycobacterium tuberculosis
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
total genus 86
structure length 281
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4if7A01
1C21A 1C23A 1Y1NA 4ZWOA 1XGSA 1XGMA 3FM3A 2BN7A 4MATA 2GU4A 4U6ZA 3TAVA 1C24A 2OAZA 1PV9A 1QXWA 3PKEA 2V3YA 2DFIA 2BHDA 3PKCA 1R58A 1BN5A 3PKAA 4IECA 2NQ7A 2BWVA 4IKSA 5CIKA 3RORA 3TB5A 2EVOA 5CE6A 4U6JA 5FCFA 2GU5A 2MATA 4PNCA 4IDYA 1WY2A 2Q94A 2HOWA 1N51A 2V3XA 4R60A 1WBQA 4S2TP 4U6CA 3PKBA 2B3KA 3FMQA 4JUQA 4IKUA 1XGOA 2V6CA 2EVCA 2Q96A 2GG8A 1B6AA 1C27A 5CDLA 4ZWPA 2GTXA 4S00A 1MATA 4U70A 1JAWA 1R5HA 2BWYA 4A6WA 3IG4A 5D6FA 2Q92A 5FCHA 2GGBA 4U6EA 4IKTA 4U69A 2GZ5A 1R5GA 3BITA 2BWSA 2BWWA 3CB6A 5CLSA 3MATA 3IU7A 1M35A 2P98A 2EA2A 3L24A 4IU6A 1W7VA 4QR8A 4RGZ1 1YW7A 1YJ3A 2ADUA 4FLLA 5CDEA 2GG2A 4FLJA 2BWXA 1B59A 2BHBA 1XNZA 1XGNA 2P99A 4U75A 1O0XA 1YVMA 1CHMA 2GG3A 2GG5A 4U1BA 4PV4A 4FLKA 1BOAA 2GG7A 2BHAA 2GU7A 4OOKA 4EGEA 1KP0A 2IW2A 3CB5A 1WLRA 5D6EA 4U6WA 2GG0A 2B3LA 2GA2A 2EA4A 4RZYA 4B28A 4Z7MA 2BB7A 5E5BA 2Q95A 3Q6DA 1YW9A 2GU6A 4ZNGA 1QZYA 2OKNA 2GG9A 2BWTA 2Q8KA 3S6BA 1A16A 3BIPA 4IPAA 1WL9A 1W2MA 2P9AA 4FLIA 4FO8A 4ZWUA 3FMRA 1WL6A 2ZSGA 2BH3A 4U71A 2G6PA 1WN1A 3IU8A 4S2RP 1QXZA 3MX6A 2B3HA 2BHCA 1KQ9A 4FKCA 2Q93A 3PKDA 4U73A 4U76A 5CNXA 4HXXA 2EVMA 4KM3A 2NQ6A 3IU9A 4FO7A 3L7GA 1QXYA 3D27A 3CTZA 4RZZA 1WKMA 3RVAA 4IF7A 4S01A 2GGCA 5CDVA 1C22A 5JHUA 1KQ0A 4IKRA 5JFRA 2BWUA 4A6VA 2V3ZA 3BIQA 1YW8A 4FUKA 3MR1A 5JI6A
chains in the Genus database with same CATH superfamily
1C21A 1C23A 1Y1NA 4ZWOA 1XGSA 1XGMA 3FM3A 2BN7A 4MATA 2GU4A 4U6ZA 3TAVA 1C24A 2OAZA 1PV9A 1QXWA 3PKEA 2V3YA 2DFIA 2BHDA 3PKCA 1R58A 1BN5A 3PKAA 4IECA 2NQ7A 2BWVA 4IKSA 5CIKA 3RORA 3TB5A 2EVOA 5CE6A 4U6JA 5FCFA 2GU5A 2MATA 4PNCA 4IDYA 1WY2A 2Q94A 2HOWA 1N51A 2V3XA 4R60A 1WBQA 4S2TP 4U6CA 3PKBA 2B3KA 3FMQA 4JUQA 4IKUA 1XGOA 2V6CA 2EVCA 2Q96A 2GG8A 1B6AA 1C27A 5CDLA 4ZWPA 2GTXA 4S00A 1MATA 4U70A 1JAWA 1R5HA 2BWYA 4A6WA 3IG4A 5D6FA 2Q92A 5FCHA 2GGBA 4U6EA 4IKTA 4U69A 2GZ5A 1R5GA 3BITA 2BWSA 2BWWA 3CB6A 5CLSA 3MATA 3IU7A 1M35A 2P98A 2EA2A 3L24A 4IU6A 1W7VA 4QR8A 4RGZ1 1YW7A 1YJ3A 2ADUA 4FLLA 5CDEA 2GG2A 4FLJA 2BWXA 1B59A 2BHBA 1XNZA 1XGNA 2P99A 4U75A 1O0XA 1YVMA 1CHMA 2GG3A 2GG5A 4U1BA 4PV4A 4FLKA 1BOAA 2GG7A 2BHAA 2GU7A 4OOKA 4EGEA 1KP0A 2IW2A 3CB5A 1WLRA 5D6EA 4U6WA 2GG0A 2B3LA 2GA2A 2EA4A 4RZYA 4B28A 4Z7MA 2BB7A 5E5BA 2Q95A 3Q6DA 1YW9A 2GU6A 4ZNGA 1QZYA 2OKNA 2GG9A 2BWTA 2Q8KA 3S6BA 1A16A 3BIPA 4IPAA 1WL9A 1W2MA 2P9AA 4FLIA 4FO8A 4ZWUA 3FMRA 1WL6A 2ZSGA 2BH3A 4U71A 2G6PA 1WN1A 3IU8A 4S2RP 1QXZA 3MX6A 2B3HA 2BHCA 1KQ9A 4FKCA 2Q93A 3PKDA 4U73A 4U76A 5CNXA 4HXXA 2EVMA 4KM3A 2NQ6A 3IU9A 4FO7A 3L7GA 1QXYA 3D27A 3CTZA 4RZZA 1WKMA 3RVAA 4IF7A 4S01A 2GGCA 5CDVA 1C22A 5JHUA 1KQ0A 4IKRA 5JFRA 2BWUA 4A6VA 2V3ZA 3BIQA 1YW8A 4FUKA 3MR1A 5JI6A
chains in the Genus database with same CATH topology
1C21A 1C23A 1Y1NA 4ZWOA 1XGSA 1XGMA 3FM3A 2BN7A 4MATA 2GU4A 4U6ZA 3TAVA 1C24A 2OAZA 1PV9A 1QXWA 3PKEA 2V3YA 2DFIA 2BHDA 3PKCA 1R58A 1BN5A 3PKAA 4IECA 2NQ7A 2BWVA 4IKSA 5CIKA 3RORA 3TB5A 2EVOA 5CE6A 4U6JA 5FCFA 2GU5A 2MATA 4PNCA 4IDYA 1WY2A 2Q94A 2HOWA 1N51A 2V3XA 4R60A 1WBQA 4S2TP 4U6CA 3PKBA 2B3KA 3FMQA 4JUQA 4IKUA 1XGOA 2V6CA 2EVCA 2Q96A 2GG8A 1B6AA 1C27A 5CDLA 4ZWPA 2GTXA 4S00A 1MATA 4U70A 1JAWA 1R5HA 2BWYA 4A6WA 3IG4A 5D6FA 2Q92A 5FCHA 2GGBA 4U6EA 4IKTA 4U69A 2GZ5A 1R5GA 3BITA 2BWSA 2BWWA 3CB6A 5CLSA 3MATA 3IU7A 1M35A 2P98A 2EA2A 3L24A 4IU6A 1W7VA 4QR8A 4RGZ1 1YW7A 1YJ3A 2ADUA 4FLLA 5CDEA 2GG2A 4FLJA 2BWXA 1B59A 2BHBA 1XNZA 1XGNA 2P99A 4U75A 1O0XA 1YVMA 1CHMA 2GG3A 2GG5A 4U1BA 4PV4A 4FLKA 1BOAA 2GG7A 2BHAA 2GU7A 4OOKA 4EGEA 1KP0A 2IW2A 3CB5A 1WLRA 5D6EA 4U6WA 2GG0A 2B3LA 2GA2A 2EA4A 4RZYA 4B28A 4Z7MA 2BB7A 5E5BA 2Q95A 3Q6DA 1YW9A 2GU6A 4ZNGA 1QZYA 2OKNA 2GG9A 2BWTA 2Q8KA 3S6BA 1A16A 3BIPA 4IPAA 1WL9A 1W2MA 2P9AA 4FLIA 4FO8A 4ZWUA 3FMRA 1WL6A 2ZSGA 2BH3A 4U71A 2G6PA 1WN1A 3IU8A 4S2RP 1QXZA 3MX6A 2B3HA 2BHCA 1KQ9A 4FKCA 2Q93A 3PKDA 4U73A 4U76A 5CNXA 4HXXA 2EVMA 4KM3A 2NQ6A 3IU9A 4FO7A 3L7GA 1QXYA 3D27A 3CTZA 4RZZA 1WKMA 3RVAA 4IF7A 4S01A 2GGCA 5CDVA 1C22A 5JHUA 1KQ0A 4IKRA 5JFRA 2BWUA 4A6VA 2V3ZA 3BIQA 1YW8A 4FUKA 3MR1A 5JI6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C21 A;  1C23 A;  1Y1N A;  4ZWO A;  1XGS A;  1XGM A;  3FM3 A;  2BN7 A;  4MAT A;  2GU4 A;  4U6Z A;  3TAV A;  1C24 A;  2OAZ A;  1PV9 A;  1QXW A;  3PKE A;  2V3Y A;  2DFI A;  2BHD A;  3PKC A;  1R58 A;  1BN5 A;  3PKA A;  4IEC A;  2NQ7 A;  2BWV A;  4IKS A;  5CIK A;  3ROR A;  3TB5 A;  2EVO A;  5CE6 A;  4U6J A;  5FCF A;  2GU5 A;  2MAT A;  4PNC A;  4IDY A;  1WY2 A;  2Q94 A;  2HOW A;  1N51 A;  2V3X A;  4R60 A;  1WBQ A;  4S2T P;  4U6C A;  3PKB A;  2B3K A;  3FMQ A;  4JUQ A;  4IKU A;  1XGO A;  2V6C A;  2EVC A;  2Q96 A;  2GG8 A;  1B6A A;  1C27 A;  5CDL A;  4ZWP A;  2GTX A;  4S00 A;  1MAT A;  4U70 A;  1JAW A;  1R5H A;  2BWY A;  4A6W A;  3IG4 A;  5D6F A;  2Q92 A;  5FCH A;  2GGB A;  4U6E A;  4IKT A;  4U69 A;  2GZ5 A;  1R5G A;  3BIT A;  2BWS A;  2BWW A;  3CB6 A;  5CLS A;  3MAT A;  3IU7 A;  1M35 A;  2P98 A;  2EA2 A;  3L24 A;  4IU6 A;  1W7V A;  4QR8 A;  4RGZ 1;  1YW7 A;  1YJ3 A;  2ADU A;  4FLL A;  5CDE A;  2GG2 A;  4FLJ A;  2BWX A;  1B59 A;  2BHB A;  1XNZ A;  1XGN A;  2P99 A;  4U75 A;  1O0X A;  1YVM A;  1CHM A;  2GG3 A;  2GG5 A;  4U1B A;  4PV4 A;  4FLK A;  1BOA A;  2GG7 A;  2BHA A;  2GU7 A;  4OOK A;  4EGE A;  1KP0 A;  2IW2 A;  3CB5 A;  1WLR A;  5D6E A;  4U6W A;  2GG0 A;  2B3L A;  2GA2 A;  2EA4 A;  4RZY A;  4B28 A;  4Z7M A;  2BB7 A;  5E5B A;  2Q95 A;  3Q6D A;  1YW9 A;  2GU6 A;  4ZNG A;  1QZY A;  2OKN A;  2GG9 A;  2BWT A;  2Q8K A;  3S6B A;  1A16 A;  3BIP A;  4IPA A;  1WL9 A;  1W2M A;  2P9A A;  4FLI A;  4FO8 A;  4ZWU A;  3FMR A;  1WL6 A;  2ZSG A;  2BH3 A;  4U71 A;  2G6P A;  1WN1 A;  3IU8 A;  4S2R P;  1QXZ A;  3MX6 A;  2B3H A;  2BHC A;  1KQ9 A;  4FKC A;  2Q93 A;  3PKD A;  4U73 A;  4U76 A;  5CNX A;  4HXX A;  2EVM A;  4KM3 A;  2NQ6 A;  3IU9 A;  4FO7 A;  3L7G A;  1QXY A;  3D27 A;  3CTZ A;  4RZZ A;  1WKM A;  3RVA A;  4IF7 A;  4S01 A;  2GGC A;  5CDV A;  1C22 A;  5JHU A;  1KQ0 A;  4IKR A;  5JFR A;  2BWU A;  4A6V A;  2V3Z A;  3BIQ A;  1YW8 A;  4FUK A;  3MR1 A;  5JI6 A; 
#chains in the Genus database with same CATH topology
 1C21 A;  1C23 A;  1Y1N A;  4ZWO A;  1XGS A;  1XGM A;  3FM3 A;  2BN7 A;  4MAT A;  2GU4 A;  4U6Z A;  3TAV A;  1C24 A;  2OAZ A;  1PV9 A;  1QXW A;  3PKE A;  2V3Y A;  2DFI A;  2BHD A;  3PKC A;  1R58 A;  1BN5 A;  3PKA A;  4IEC A;  2NQ7 A;  2BWV A;  4IKS A;  5CIK A;  3ROR A;  3TB5 A;  2EVO A;  5CE6 A;  4U6J A;  5FCF A;  2GU5 A;  2MAT A;  4PNC A;  4IDY A;  1WY2 A;  2Q94 A;  2HOW A;  1N51 A;  2V3X A;  4R60 A;  1WBQ A;  4S2T P;  4U6C A;  3PKB A;  2B3K A;  3FMQ A;  4JUQ A;  4IKU A;  1XGO A;  2V6C A;  2EVC A;  2Q96 A;  2GG8 A;  1B6A A;  1C27 A;  5CDL A;  4ZWP A;  2GTX A;  4S00 A;  1MAT A;  4U70 A;  1JAW A;  1R5H A;  2BWY A;  4A6W A;  3IG4 A;  5D6F A;  2Q92 A;  5FCH A;  2GGB A;  4U6E A;  4IKT A;  4U69 A;  2GZ5 A;  1R5G A;  3BIT A;  2BWS A;  2BWW A;  3CB6 A;  5CLS A;  3MAT A;  3IU7 A;  1M35 A;  2P98 A;  2EA2 A;  3L24 A;  4IU6 A;  1W7V A;  4QR8 A;  4RGZ 1;  1YW7 A;  1YJ3 A;  2ADU A;  4FLL A;  5CDE A;  2GG2 A;  4FLJ A;  2BWX A;  1B59 A;  2BHB A;  1XNZ A;  1XGN A;  2P99 A;  4U75 A;  1O0X A;  1YVM A;  1CHM A;  2GG3 A;  2GG5 A;  4U1B A;  4PV4 A;  4FLK A;  1BOA A;  2GG7 A;  2BHA A;  2GU7 A;  4OOK A;  4EGE A;  1KP0 A;  2IW2 A;  3CB5 A;  1WLR A;  5D6E A;  4U6W A;  2GG0 A;  2B3L A;  2GA2 A;  2EA4 A;  4RZY A;  4B28 A;  4Z7M A;  2BB7 A;  5E5B A;  2Q95 A;  3Q6D A;  1YW9 A;  2GU6 A;  4ZNG A;  1QZY A;  2OKN A;  2GG9 A;  2BWT A;  2Q8K A;  3S6B A;  1A16 A;  3BIP A;  4IPA A;  1WL9 A;  1W2M A;  2P9A A;  4FLI A;  4FO8 A;  4ZWU A;  3FMR A;  1WL6 A;  2ZSG A;  2BH3 A;  4U71 A;  2G6P A;  1WN1 A;  3IU8 A;  4S2R P;  1QXZ A;  3MX6 A;  2B3H A;  2BHC A;  1KQ9 A;  4FKC A;  2Q93 A;  3PKD A;  4U73 A;  4U76 A;  5CNX A;  4HXX A;  2EVM A;  4KM3 A;  2NQ6 A;  3IU9 A;  4FO7 A;  3L7G A;  1QXY A;  3D27 A;  3CTZ A;  4RZZ A;  1WKM A;  3RVA A;  4IF7 A;  4S01 A;  2GGC A;  5CDV A;  1C22 A;  5JHU A;  1KQ0 A;  4IKR A;  5JFR A;  2BWU A;  4A6V A;  2V3Z A;  3BIQ A;  1YW8 A;  4FUK A;  3MR1 A;  5JI6 A; 
#chains in the Genus database with same CATH homology
 1C21 A;  1C23 A;  1Y1N A;  4ZWO A;  1XGS A;  1XGM A;  3FM3 A;  2BN7 A;  4MAT A;  2GU4 A;  4U6Z A;  3TAV A;  1C24 A;  2OAZ A;  1PV9 A;  1QXW A;  3PKE A;  2V3Y A;  2DFI A;  2BHD A;  3PKC A;  1R58 A;  1BN5 A;  3PKA A;  4IEC A;  2NQ7 A;  2BWV A;  4IKS A;  5CIK A;  3ROR A;  3TB5 A;  2EVO A;  5CE6 A;  4U6J A;  5FCF A;  2GU5 A;  2MAT A;  4PNC A;  4IDY A;  1WY2 A;  2Q94 A;  2HOW A;  1N51 A;  2V3X A;  4R60 A;  1WBQ A;  4S2T P;  4U6C A;  3PKB A;  2B3K A;  3FMQ A;  4JUQ A;  4IKU A;  1XGO A;  2V6C A;  2EVC A;  2Q96 A;  2GG8 A;  1B6A A;  1C27 A;  5CDL A;  4ZWP A;  2GTX A;  4S00 A;  1MAT A;  4U70 A;  1JAW A;  1R5H A;  2BWY A;  4A6W A;  3IG4 A;  5D6F A;  2Q92 A;  5FCH A;  2GGB A;  4U6E A;  4IKT A;  4U69 A;  2GZ5 A;  1R5G A;  3BIT A;  2BWS A;  2BWW A;  3CB6 A;  5CLS A;  3MAT A;  3IU7 A;  1M35 A;  2P98 A;  2EA2 A;  3L24 A;  4IU6 A;  1W7V A;  4QR8 A;  4RGZ 1;  1YW7 A;  1YJ3 A;  2ADU A;  4FLL A;  5CDE A;  2GG2 A;  4FLJ A;  2BWX A;  1B59 A;  2BHB A;  1XNZ A;  1XGN A;  2P99 A;  4U75 A;  1O0X A;  1YVM A;  1CHM A;  2GG3 A;  2GG5 A;  4U1B A;  4PV4 A;  4FLK A;  1BOA A;  2GG7 A;  2BHA A;  2GU7 A;  4OOK A;  4EGE A;  1KP0 A;  2IW2 A;  3CB5 A;  1WLR A;  5D6E A;  4U6W A;  2GG0 A;  2B3L A;  2GA2 A;  2EA4 A;  4RZY A;  4B28 A;  4Z7M A;  2BB7 A;  5E5B A;  2Q95 A;  3Q6D A;  1YW9 A;  2GU6 A;  4ZNG A;  1QZY A;  2OKN A;  2GG9 A;  2BWT A;  2Q8K A;  3S6B A;  1A16 A;  3BIP A;  4IPA A;  1WL9 A;  1W2M A;  2P9A A;  4FLI A;  4FO8 A;  4ZWU A;  3FMR A;  1WL6 A;  2ZSG A;  2BH3 A;  4U71 A;  2G6P A;  1WN1 A;  3IU8 A;  4S2R P;  1QXZ A;  3MX6 A;  2B3H A;  2BHC A;  1KQ9 A;  4FKC A;  2Q93 A;  3PKD A;  4U73 A;  4U76 A;  5CNX A;  4HXX A;  2EVM A;  4KM3 A;  2NQ6 A;  3IU9 A;  4FO7 A;  3L7G A;  1QXY A;  3D27 A;  3CTZ A;  4RZZ A;  1WKM A;  3RVA A;  4IF7 A;  4S01 A;  2GGC A;  5CDV A;  1C22 A;  5JHU A;  1KQ0 A;  4IKR A;  5JFR A;  2BWU A;  4A6V A;  2V3Z A;  3BIQ A;  1YW8 A;  4FUK A;  3MR1 A;  5JI6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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