4IF7A

Mycobacterium tuberculosis methionine aminopeptidase type 1c in complex with homocysteine-methyl disulfide
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
281
Chain Sequence
b'RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Methionine aminopeptidase 2
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 86
structure length 281
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4if7A01
5E5BA 2EVCA 2GG0A 4ZWPA 4S01A 4HXXA 4A6WA 3CTZA 1BN5A 4RGZ1 2BH3A 4B28A 5JFRA 1XGSA 2GU5A 1WL6A 3BIPA 4A6VA 4JUQA 3MATA 1JAWA 4Z7MA 2BWYA 3PKBA 2Q92A 4FO7A 5JHUA 4FLJA 3CB6A 4PV4A 3S6BA 1A16A 4U6CA 4IPAA 2GG9A 4QR8A 1CHMA 1XGNA 1O0XA 2BN7A 5FCFA 4U6WA 3D27A 2GA2A 2BWWA 2NQ7A 3L7GA 5CLSA 2BHAA 2BB7A 1XGOA 4IF7A 4RZZA 2B3LA 1KQ9A 5CNXA 1N51A 1C21A 2BHBA 4U6ZA 2P99A 3RORA 2EVOA 1C24A 4FLKA 2V3ZA 4EGEA 2OKNA 2IW2A 4S2TP 1KQ0A 1R5GA 1Y1NA 2ZSGA 2GG3A 2BHCA 2DFIA 2P9AA 2BHDA 2Q8KA 4FO8A 4S00A 3PKDA 2GG7A 4R60A 3RVAA 2GGBA 3FMQA 1C22A 1WKMA 2BWUA 1C27A 4IKTA 4U69A 4IKUA 1BOAA 2V3YA 3MR1A 4FUKA 2EA2A 1QXWA 2GGCA 4U6JA 1XGMA 2Q94A 2V3XA 1KP0A 2Q96A 4MATA 2Q95A 5FCHA 2GU7A 5CDEA 2GU4A 1YW7A 1B59A 4S2RP 1WY2A 3MX6A 5D6EA 3CB5A 2EVMA 2BWSA 4U73A 1C23A 3TB5A 2B3HA 4IU6A 1QXZA 3PKCA 1WBQA 4IDYA 5CDLA 2BWXA 1YJ3A 2OAZA 2HOWA 4FKCA 4OOKA 3PKEA 2BWTA 5D6FA 4FLLA 5CIKA 2G6PA 3Q6DA 4U71A 1R58A 1W2MA 1WN1A 2V6CA 4IKRA 2BWVA 4U6EA 5CE6A 4ZNGA 4FLIA 5CDVA 4U70A 3IG4A 3BITA 4RZYA 4KM3A 3BIQA 1XNZA 1M35A 3FM3A 1W7VA 4IECA 2GU6A 4U75A 1QZYA 4U76A 2P98A 1QXYA 1WLRA 2EA4A 2ADUA 2B3KA 1YVMA 4ZWUA 1R5HA 1PV9A 2GTXA 3PKAA 1YW8A 2GG5A 4IKSA 1YW9A 1WL9A 2GG8A 3IU7A 3IU9A 4PNCA 3TAVA 2NQ6A 3L24A 4U1BA 1B6AA 2MATA 2GG2A 2Q93A 3FMRA 3IU8A 4ZWOA 1MATA 2GZ5A 5JI6A
chains in the Genus database with same CATH superfamily
5E5BA 2EVCA 2GG0A 4ZWPA 4S01A 4HXXA 4A6WA 3CTZA 1BN5A 4RGZ1 2BH3A 4B28A 5JFRA 1XGSA 2GU5A 1WL6A 3BIPA 4A6VA 4JUQA 3MATA 1JAWA 4Z7MA 2BWYA 3PKBA 2Q92A 4FO7A 5JHUA 4FLJA 3CB6A 4PV4A 3S6BA 1A16A 4U6CA 4IPAA 2GG9A 4QR8A 1CHMA 1XGNA 1O0XA 2BN7A 5FCFA 4U6WA 3D27A 2GA2A 2BWWA 2NQ7A 3L7GA 5CLSA 2BHAA 2BB7A 1XGOA 4IF7A 4RZZA 2B3LA 1KQ9A 5CNXA 1N51A 1C21A 2BHBA 4U6ZA 2P99A 3RORA 2EVOA 1C24A 4FLKA 2V3ZA 4EGEA 2OKNA 2IW2A 4S2TP 1KQ0A 1R5GA 1Y1NA 2ZSGA 2GG3A 2BHCA 2DFIA 2P9AA 2BHDA 2Q8KA 4FO8A 4S00A 3PKDA 2GG7A 4R60A 3RVAA 2GGBA 3FMQA 1C22A 1WKMA 2BWUA 1C27A 4IKTA 4U69A 4IKUA 1BOAA 2V3YA 3MR1A 4FUKA 2EA2A 1QXWA 2GGCA 4U6JA 1XGMA 2Q94A 2V3XA 1KP0A 2Q96A 4MATA 2Q95A 5FCHA 2GU7A 5CDEA 2GU4A 1YW7A 1B59A 4S2RP 1WY2A 3MX6A 5D6EA 3CB5A 2EVMA 2BWSA 4U73A 1C23A 3TB5A 2B3HA 4IU6A 1QXZA 3PKCA 1WBQA 4IDYA 5CDLA 2BWXA 1YJ3A 2OAZA 2HOWA 4FKCA 4OOKA 3PKEA 2BWTA 5D6FA 4FLLA 5CIKA 2G6PA 3Q6DA 4U71A 1R58A 1W2MA 1WN1A 2V6CA 4IKRA 2BWVA 4U6EA 5CE6A 4ZNGA 4FLIA 5CDVA 4U70A 3IG4A 3BITA 4RZYA 4KM3A 3BIQA 1XNZA 1M35A 3FM3A 1W7VA 4IECA 2GU6A 4U75A 1QZYA 4U76A 2P98A 1QXYA 1WLRA 2EA4A 2ADUA 2B3KA 1YVMA 4ZWUA 1R5HA 1PV9A 2GTXA 3PKAA 1YW8A 2GG5A 4IKSA 1YW9A 1WL9A 2GG8A 3IU7A 3IU9A 4PNCA 3TAVA 2NQ6A 3L24A 4U1BA 1B6AA 2MATA 2GG2A 2Q93A 3FMRA 3IU8A 4ZWOA 1MATA 2GZ5A 5JI6A
chains in the Genus database with same CATH topology
5E5BA 2EVCA 2GG0A 4ZWPA 4S01A 4HXXA 4A6WA 3CTZA 1BN5A 4RGZ1 2BH3A 4B28A 5JFRA 1XGSA 2GU5A 1WL6A 3BIPA 4A6VA 4JUQA 3MATA 1JAWA 4Z7MA 2BWYA 3PKBA 2Q92A 4FO7A 5JHUA 4FLJA 3CB6A 4PV4A 3S6BA 1A16A 4U6CA 4IPAA 2GG9A 4QR8A 1CHMA 1XGNA 1O0XA 2BN7A 5FCFA 4U6WA 3D27A 2GA2A 2BWWA 2NQ7A 3L7GA 5CLSA 2BHAA 2BB7A 1XGOA 4IF7A 4RZZA 2B3LA 1KQ9A 5CNXA 1N51A 1C21A 2BHBA 4U6ZA 2P99A 3RORA 2EVOA 1C24A 4FLKA 2V3ZA 4EGEA 2OKNA 2IW2A 4S2TP 1KQ0A 1R5GA 1Y1NA 2ZSGA 2GG3A 2BHCA 2DFIA 2P9AA 2BHDA 2Q8KA 4FO8A 4S00A 3PKDA 2GG7A 4R60A 3RVAA 2GGBA 3FMQA 1C22A 1WKMA 2BWUA 1C27A 4IKTA 4U69A 4IKUA 1BOAA 2V3YA 3MR1A 4FUKA 2EA2A 1QXWA 2GGCA 4U6JA 1XGMA 2Q94A 2V3XA 1KP0A 2Q96A 4MATA 2Q95A 5FCHA 2GU7A 5CDEA 2GU4A 1YW7A 1B59A 4S2RP 1WY2A 3MX6A 5D6EA 3CB5A 2EVMA 2BWSA 4U73A 1C23A 3TB5A 2B3HA 4IU6A 1QXZA 3PKCA 1WBQA 4IDYA 5CDLA 2BWXA 1YJ3A 2OAZA 2HOWA 4FKCA 4OOKA 3PKEA 2BWTA 5D6FA 4FLLA 5CIKA 2G6PA 3Q6DA 4U71A 1R58A 1W2MA 1WN1A 2V6CA 4IKRA 2BWVA 4U6EA 5CE6A 4ZNGA 4FLIA 5CDVA 4U70A 3IG4A 3BITA 4RZYA 4KM3A 3BIQA 1XNZA 1M35A 3FM3A 1W7VA 4IECA 2GU6A 4U75A 1QZYA 4U76A 2P98A 1QXYA 1WLRA 2EA4A 2ADUA 2B3KA 1YVMA 4ZWUA 1R5HA 1PV9A 2GTXA 3PKAA 1YW8A 2GG5A 4IKSA 1YW9A 1WL9A 2GG8A 3IU7A 3IU9A 4PNCA 3TAVA 2NQ6A 3L24A 4U1BA 1B6AA 2MATA 2GG2A 2Q93A 3FMRA 3IU8A 4ZWOA 1MATA 2GZ5A 5JI6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5E5B A;  2EVC A;  2GG0 A;  4ZWP A;  4S01 A;  4HXX A;  4A6W A;  3CTZ A;  1BN5 A;  4RGZ 1;  2BH3 A;  4B28 A;  5JFR A;  1XGS A;  2GU5 A;  1WL6 A;  3BIP A;  4A6V A;  4JUQ A;  3MAT A;  1JAW A;  4Z7M A;  2BWY A;  3PKB A;  2Q92 A;  4FO7 A;  5JHU A;  4FLJ A;  3CB6 A;  4PV4 A;  3S6B A;  1A16 A;  4U6C A;  4IPA A;  2GG9 A;  4QR8 A;  1CHM A;  1XGN A;  1O0X A;  2BN7 A;  5FCF A;  4U6W A;  3D27 A;  2GA2 A;  2BWW A;  2NQ7 A;  3L7G A;  5CLS A;  2BHA A;  2BB7 A;  1XGO A;  4IF7 A;  4RZZ A;  2B3L A;  1KQ9 A;  5CNX A;  1N51 A;  1C21 A;  2BHB A;  4U6Z A;  2P99 A;  3ROR A;  2EVO A;  1C24 A;  4FLK A;  2V3Z A;  4EGE A;  2OKN A;  2IW2 A;  4S2T P;  1KQ0 A;  1R5G A;  1Y1N A;  2ZSG A;  2GG3 A;  2BHC A;  2DFI A;  2P9A A;  2BHD A;  2Q8K A;  4FO8 A;  4S00 A;  3PKD A;  2GG7 A;  4R60 A;  3RVA A;  2GGB A;  3FMQ A;  1C22 A;  1WKM A;  2BWU A;  1C27 A;  4IKT A;  4U69 A;  4IKU A;  1BOA A;  2V3Y A;  3MR1 A;  4FUK A;  2EA2 A;  1QXW A;  2GGC A;  4U6J A;  1XGM A;  2Q94 A;  2V3X A;  1KP0 A;  2Q96 A;  4MAT A;  2Q95 A;  5FCH A;  2GU7 A;  5CDE A;  2GU4 A;  1YW7 A;  1B59 A;  4S2R P;  1WY2 A;  3MX6 A;  5D6E A;  3CB5 A;  2EVM A;  2BWS A;  4U73 A;  1C23 A;  3TB5 A;  2B3H A;  4IU6 A;  1QXZ A;  3PKC A;  1WBQ A;  4IDY A;  5CDL A;  2BWX A;  1YJ3 A;  2OAZ A;  2HOW A;  4FKC A;  4OOK A;  3PKE A;  2BWT A;  5D6F A;  4FLL A;  5CIK A;  2G6P A;  3Q6D A;  4U71 A;  1R58 A;  1W2M A;  1WN1 A;  2V6C A;  4IKR A;  2BWV A;  4U6E A;  5CE6 A;  4ZNG A;  4FLI A;  5CDV A;  4U70 A;  3IG4 A;  3BIT A;  4RZY A;  4KM3 A;  3BIQ A;  1XNZ A;  1M35 A;  3FM3 A;  1W7V A;  4IEC A;  2GU6 A;  4U75 A;  1QZY A;  4U76 A;  2P98 A;  1QXY A;  1WLR A;  2EA4 A;  2ADU A;  2B3K A;  1YVM A;  4ZWU A;  1R5H A;  1PV9 A;  2GTX A;  3PKA A;  1YW8 A;  2GG5 A;  4IKS A;  1YW9 A;  1WL9 A;  2GG8 A;  3IU7 A;  3IU9 A;  4PNC A;  3TAV A;  2NQ6 A;  3L24 A;  4U1B A;  1B6A A;  2MAT A;  2GG2 A;  2Q93 A;  3FMR A;  3IU8 A;  4ZWO A;  1MAT A;  2GZ5 A;  5JI6 A; 
#chains in the Genus database with same CATH topology
 5E5B A;  2EVC A;  2GG0 A;  4ZWP A;  4S01 A;  4HXX A;  4A6W A;  3CTZ A;  1BN5 A;  4RGZ 1;  2BH3 A;  4B28 A;  5JFR A;  1XGS A;  2GU5 A;  1WL6 A;  3BIP A;  4A6V A;  4JUQ A;  3MAT A;  1JAW A;  4Z7M A;  2BWY A;  3PKB A;  2Q92 A;  4FO7 A;  5JHU A;  4FLJ A;  3CB6 A;  4PV4 A;  3S6B A;  1A16 A;  4U6C A;  4IPA A;  2GG9 A;  4QR8 A;  1CHM A;  1XGN A;  1O0X A;  2BN7 A;  5FCF A;  4U6W A;  3D27 A;  2GA2 A;  2BWW A;  2NQ7 A;  3L7G A;  5CLS A;  2BHA A;  2BB7 A;  1XGO A;  4IF7 A;  4RZZ A;  2B3L A;  1KQ9 A;  5CNX A;  1N51 A;  1C21 A;  2BHB A;  4U6Z A;  2P99 A;  3ROR A;  2EVO A;  1C24 A;  4FLK A;  2V3Z A;  4EGE A;  2OKN A;  2IW2 A;  4S2T P;  1KQ0 A;  1R5G A;  1Y1N A;  2ZSG A;  2GG3 A;  2BHC A;  2DFI A;  2P9A A;  2BHD A;  2Q8K A;  4FO8 A;  4S00 A;  3PKD A;  2GG7 A;  4R60 A;  3RVA A;  2GGB A;  3FMQ A;  1C22 A;  1WKM A;  2BWU A;  1C27 A;  4IKT A;  4U69 A;  4IKU A;  1BOA A;  2V3Y A;  3MR1 A;  4FUK A;  2EA2 A;  1QXW A;  2GGC A;  4U6J A;  1XGM A;  2Q94 A;  2V3X A;  1KP0 A;  2Q96 A;  4MAT A;  2Q95 A;  5FCH A;  2GU7 A;  5CDE A;  2GU4 A;  1YW7 A;  1B59 A;  4S2R P;  1WY2 A;  3MX6 A;  5D6E A;  3CB5 A;  2EVM A;  2BWS A;  4U73 A;  1C23 A;  3TB5 A;  2B3H A;  4IU6 A;  1QXZ A;  3PKC A;  1WBQ A;  4IDY A;  5CDL A;  2BWX A;  1YJ3 A;  2OAZ A;  2HOW A;  4FKC A;  4OOK A;  3PKE A;  2BWT A;  5D6F A;  4FLL A;  5CIK A;  2G6P A;  3Q6D A;  4U71 A;  1R58 A;  1W2M A;  1WN1 A;  2V6C A;  4IKR A;  2BWV A;  4U6E A;  5CE6 A;  4ZNG A;  4FLI A;  5CDV A;  4U70 A;  3IG4 A;  3BIT A;  4RZY A;  4KM3 A;  3BIQ A;  1XNZ A;  1M35 A;  3FM3 A;  1W7V A;  4IEC A;  2GU6 A;  4U75 A;  1QZY A;  4U76 A;  2P98 A;  1QXY A;  1WLR A;  2EA4 A;  2ADU A;  2B3K A;  1YVM A;  4ZWU A;  1R5H A;  1PV9 A;  2GTX A;  3PKA A;  1YW8 A;  2GG5 A;  4IKS A;  1YW9 A;  1WL9 A;  2GG8 A;  3IU7 A;  3IU9 A;  4PNC A;  3TAV A;  2NQ6 A;  3L24 A;  4U1B A;  1B6A A;  2MAT A;  2GG2 A;  2Q93 A;  3FMR A;  3IU8 A;  4ZWO A;  1MAT A;  2GZ5 A;  5JI6 A; 
#chains in the Genus database with same CATH homology
 5E5B A;  2EVC A;  2GG0 A;  4ZWP A;  4S01 A;  4HXX A;  4A6W A;  3CTZ A;  1BN5 A;  4RGZ 1;  2BH3 A;  4B28 A;  5JFR A;  1XGS A;  2GU5 A;  1WL6 A;  3BIP A;  4A6V A;  4JUQ A;  3MAT A;  1JAW A;  4Z7M A;  2BWY A;  3PKB A;  2Q92 A;  4FO7 A;  5JHU A;  4FLJ A;  3CB6 A;  4PV4 A;  3S6B A;  1A16 A;  4U6C A;  4IPA A;  2GG9 A;  4QR8 A;  1CHM A;  1XGN A;  1O0X A;  2BN7 A;  5FCF A;  4U6W A;  3D27 A;  2GA2 A;  2BWW A;  2NQ7 A;  3L7G A;  5CLS A;  2BHA A;  2BB7 A;  1XGO A;  4IF7 A;  4RZZ A;  2B3L A;  1KQ9 A;  5CNX A;  1N51 A;  1C21 A;  2BHB A;  4U6Z A;  2P99 A;  3ROR A;  2EVO A;  1C24 A;  4FLK A;  2V3Z A;  4EGE A;  2OKN A;  2IW2 A;  4S2T P;  1KQ0 A;  1R5G A;  1Y1N A;  2ZSG A;  2GG3 A;  2BHC A;  2DFI A;  2P9A A;  2BHD A;  2Q8K A;  4FO8 A;  4S00 A;  3PKD A;  2GG7 A;  4R60 A;  3RVA A;  2GGB A;  3FMQ A;  1C22 A;  1WKM A;  2BWU A;  1C27 A;  4IKT A;  4U69 A;  4IKU A;  1BOA A;  2V3Y A;  3MR1 A;  4FUK A;  2EA2 A;  1QXW A;  2GGC A;  4U6J A;  1XGM A;  2Q94 A;  2V3X A;  1KP0 A;  2Q96 A;  4MAT A;  2Q95 A;  5FCH A;  2GU7 A;  5CDE A;  2GU4 A;  1YW7 A;  1B59 A;  4S2R P;  1WY2 A;  3MX6 A;  5D6E A;  3CB5 A;  2EVM A;  2BWS A;  4U73 A;  1C23 A;  3TB5 A;  2B3H A;  4IU6 A;  1QXZ A;  3PKC A;  1WBQ A;  4IDY A;  5CDL A;  2BWX A;  1YJ3 A;  2OAZ A;  2HOW A;  4FKC A;  4OOK A;  3PKE A;  2BWT A;  5D6F A;  4FLL A;  5CIK A;  2G6P A;  3Q6D A;  4U71 A;  1R58 A;  1W2M A;  1WN1 A;  2V6C A;  4IKR A;  2BWV A;  4U6E A;  5CE6 A;  4ZNG A;  4FLI A;  5CDV A;  4U70 A;  3IG4 A;  3BIT A;  4RZY A;  4KM3 A;  3BIQ A;  1XNZ A;  1M35 A;  3FM3 A;  1W7V A;  4IEC A;  2GU6 A;  4U75 A;  1QZY A;  4U76 A;  2P98 A;  1QXY A;  1WLR A;  2EA4 A;  2ADU A;  2B3K A;  1YVM A;  4ZWU A;  1R5H A;  1PV9 A;  2GTX A;  3PKA A;  1YW8 A;  2GG5 A;  4IKS A;  1YW9 A;  1WL9 A;  2GG8 A;  3IU7 A;  3IU9 A;  4PNC A;  3TAV A;  2NQ6 A;  3L24 A;  4U1B A;  1B6A A;  2MAT A;  2GG2 A;  2Q93 A;  3FMR A;  3IU8 A;  4ZWO A;  1MAT A;  2GZ5 A;  5JI6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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