4IF7A

Mycobacterium tuberculosis methionine aminopeptidase type 1c in complex with homocysteine-methyl disulfide
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
281
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Methionine aminopeptidase 2
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 86
structure length 281
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4if7A01
2GG3A 4IKRA 5JI6A 1W7VA 3Q6DA 1BOAA 2GU4A 5CIKA 2Q94A 1R5GA 2B3HA 4HXXA 4IECA 4S01A 1KQ0A 4S2TP 2EA4A 5CDLA 2V6CA 2EVMA 4B28A 1QXZA 3PKBA 1C21A 3PKEA 2BWWA 4EGEA 2G6PA 5JHUA 3MX6A 5E5BA 2EVCA 4ZWUA 3BIQA 2GGBA 4U6JA 5CDVA 2GG7A 1QXYA 2BB7A 4KM3A 2BWVA 1BN5A 2GTXA 1M35A 2GGCA 3CB5A 4IU6A 4S2RP 5CLSA 3RORA 2DFIA 5FCFA 4QR8A 1Y1NA 3L7GA 2ZSGA 2Q95A 4U76A 2BWTA 4U6WA 2Q96A 1XGMA 1PV9A 3MATA 4U69A 3IU7A 2Q93A 1B59A 4U1BA 4RGZ1 1WL9A 2NQ7A 1QXWA 3RVAA 2BHAA 2P99A 4Z7MA 3L24A 4FUKA 2Q8KA 2GG2A 4IKTA 2BH3A 1CHMA 1WN1A 2GG8A 5JFRA 4IKSA 4IPAA 2OKNA 5CDEA 2HOWA 2MATA 4MATA 4FKCA 4ZNGA 3IU8A 1C23A 1R5HA 1MATA 5D6EA 2BN7A 3PKAA 3PKCA 4U71A 4A6WA 1WLRA 1XGNA 4U6CA 4U70A 1YW7A 1XNZA 4FLLA 4IF7A 2EVOA 2GU6A 3BIPA 1XGSA 3FMQA 4FLKA 3S6BA 4R60A 1R58A 5D6FA 2B3LA 1B6AA 2BWYA 2P98A 1W2MA 4PV4A 1N51A 3IU9A 2GZ5A 3PKDA 4OOKA 5FCHA 4RZYA 2GU5A 2BWSA 1A16A 1YVMA 4ZWOA 1O0XA 1QZYA 4PNCA 4FLJA 1C24A 4JUQA 2BHBA 3D27A 2GG5A 3FMRA 2BHCA 1KP0A 1JAWA 3IG4A 2P9AA 5CNXA 2BWXA 2B3KA 2ADUA 2IW2A 1WBQA 1YW8A 4IKUA 2NQ6A 2V3ZA 4S00A 1C22A 4FO8A 2GG0A 1C27A 1WL6A 2GA2A 2OAZA 1KQ9A 4FO7A 4RZZA 3TAVA 4U75A 2BHDA 3FM3A 4U6ZA 4FLIA 4U73A 3BITA 4A6VA 2BWUA 3TB5A 2GG9A 1WY2A 2EA2A 1XGOA 4U6EA 1YW9A 2GU7A 4ZWPA 1YJ3A 4IDYA 3MR1A 1WKMA 5CE6A 3CB6A 2V3XA 2Q92A 3CTZA 2V3YA
chains in the Genus database with same CATH superfamily
2GG3A 4IKRA 5JI6A 1W7VA 3Q6DA 1BOAA 2GU4A 5CIKA 2Q94A 1R5GA 2B3HA 4HXXA 4IECA 4S01A 1KQ0A 4S2TP 2EA4A 5CDLA 2V6CA 2EVMA 4B28A 1QXZA 3PKBA 1C21A 3PKEA 2BWWA 4EGEA 2G6PA 5JHUA 3MX6A 5E5BA 2EVCA 4ZWUA 3BIQA 2GGBA 4U6JA 5CDVA 2GG7A 1QXYA 2BB7A 4KM3A 2BWVA 1BN5A 2GTXA 1M35A 2GGCA 3CB5A 4IU6A 4S2RP 5CLSA 3RORA 2DFIA 5FCFA 4QR8A 1Y1NA 3L7GA 2ZSGA 2Q95A 4U76A 2BWTA 4U6WA 2Q96A 1XGMA 1PV9A 3MATA 4U69A 3IU7A 2Q93A 1B59A 4U1BA 4RGZ1 1WL9A 2NQ7A 1QXWA 3RVAA 2BHAA 2P99A 4Z7MA 3L24A 4FUKA 2Q8KA 2GG2A 4IKTA 2BH3A 1CHMA 1WN1A 2GG8A 5JFRA 4IKSA 4IPAA 2OKNA 5CDEA 2HOWA 2MATA 4MATA 4FKCA 4ZNGA 3IU8A 1C23A 1R5HA 1MATA 5D6EA 2BN7A 3PKAA 3PKCA 4U71A 4A6WA 1WLRA 1XGNA 4U6CA 4U70A 1YW7A 1XNZA 4FLLA 4IF7A 2EVOA 2GU6A 3BIPA 1XGSA 3FMQA 4FLKA 3S6BA 4R60A 1R58A 5D6FA 2B3LA 1B6AA 2BWYA 2P98A 1W2MA 4PV4A 1N51A 3IU9A 2GZ5A 3PKDA 4OOKA 5FCHA 4RZYA 2GU5A 2BWSA 1A16A 1YVMA 4ZWOA 1O0XA 1QZYA 4PNCA 4FLJA 1C24A 4JUQA 2BHBA 3D27A 2GG5A 3FMRA 2BHCA 1KP0A 1JAWA 3IG4A 2P9AA 5CNXA 2BWXA 2B3KA 2ADUA 2IW2A 1WBQA 1YW8A 4IKUA 2NQ6A 2V3ZA 4S00A 1C22A 4FO8A 2GG0A 1C27A 1WL6A 2GA2A 2OAZA 1KQ9A 4FO7A 4RZZA 3TAVA 4U75A 2BHDA 3FM3A 4U6ZA 4FLIA 4U73A 3BITA 4A6VA 2BWUA 3TB5A 2GG9A 1WY2A 2EA2A 1XGOA 4U6EA 1YW9A 2GU7A 4ZWPA 1YJ3A 4IDYA 3MR1A 1WKMA 5CE6A 3CB6A 2V3XA 2Q92A 3CTZA 2V3YA
chains in the Genus database with same CATH topology
2GG3A 4IKRA 5JI6A 1W7VA 3Q6DA 1BOAA 2GU4A 5CIKA 2Q94A 1R5GA 2B3HA 4HXXA 4IECA 4S01A 1KQ0A 4S2TP 2EA4A 5CDLA 2V6CA 2EVMA 4B28A 1QXZA 3PKBA 1C21A 3PKEA 2BWWA 4EGEA 2G6PA 5JHUA 3MX6A 5E5BA 2EVCA 4ZWUA 3BIQA 2GGBA 4U6JA 5CDVA 2GG7A 1QXYA 2BB7A 4KM3A 2BWVA 1BN5A 2GTXA 1M35A 2GGCA 3CB5A 4IU6A 4S2RP 5CLSA 3RORA 2DFIA 5FCFA 4QR8A 1Y1NA 3L7GA 2ZSGA 2Q95A 4U76A 2BWTA 4U6WA 2Q96A 1XGMA 1PV9A 3MATA 4U69A 3IU7A 2Q93A 1B59A 4U1BA 4RGZ1 1WL9A 2NQ7A 1QXWA 3RVAA 2BHAA 2P99A 4Z7MA 3L24A 4FUKA 2Q8KA 2GG2A 4IKTA 2BH3A 1CHMA 1WN1A 2GG8A 5JFRA 4IKSA 4IPAA 2OKNA 5CDEA 2HOWA 2MATA 4MATA 4FKCA 4ZNGA 3IU8A 1C23A 1R5HA 1MATA 5D6EA 2BN7A 3PKAA 3PKCA 4U71A 4A6WA 1WLRA 1XGNA 4U6CA 4U70A 1YW7A 1XNZA 4FLLA 4IF7A 2EVOA 2GU6A 3BIPA 1XGSA 3FMQA 4FLKA 3S6BA 4R60A 1R58A 5D6FA 2B3LA 1B6AA 2BWYA 2P98A 1W2MA 4PV4A 1N51A 3IU9A 2GZ5A 3PKDA 4OOKA 5FCHA 4RZYA 2GU5A 2BWSA 1A16A 1YVMA 4ZWOA 1O0XA 1QZYA 4PNCA 4FLJA 1C24A 4JUQA 2BHBA 3D27A 2GG5A 3FMRA 2BHCA 1KP0A 1JAWA 3IG4A 2P9AA 5CNXA 2BWXA 2B3KA 2ADUA 2IW2A 1WBQA 1YW8A 4IKUA 2NQ6A 2V3ZA 4S00A 1C22A 4FO8A 2GG0A 1C27A 1WL6A 2GA2A 2OAZA 1KQ9A 4FO7A 4RZZA 3TAVA 4U75A 2BHDA 3FM3A 4U6ZA 4FLIA 4U73A 3BITA 4A6VA 2BWUA 3TB5A 2GG9A 1WY2A 2EA2A 1XGOA 4U6EA 1YW9A 2GU7A 4ZWPA 1YJ3A 4IDYA 3MR1A 1WKMA 5CE6A 3CB6A 2V3XA 2Q92A 3CTZA 2V3YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GG3 A;  4IKR A;  5JI6 A;  1W7V A;  3Q6D A;  1BOA A;  2GU4 A;  5CIK A;  2Q94 A;  1R5G A;  2B3H A;  4HXX A;  4IEC A;  4S01 A;  1KQ0 A;  4S2T P;  2EA4 A;  5CDL A;  2V6C A;  2EVM A;  4B28 A;  1QXZ A;  3PKB A;  1C21 A;  3PKE A;  2BWW A;  4EGE A;  2G6P A;  5JHU A;  3MX6 A;  5E5B A;  2EVC A;  4ZWU A;  3BIQ A;  2GGB A;  4U6J A;  5CDV A;  2GG7 A;  1QXY A;  2BB7 A;  4KM3 A;  2BWV A;  1BN5 A;  2GTX A;  1M35 A;  2GGC A;  3CB5 A;  4IU6 A;  4S2R P;  5CLS A;  3ROR A;  2DFI A;  5FCF A;  4QR8 A;  1Y1N A;  3L7G A;  2ZSG A;  2Q95 A;  4U76 A;  2BWT A;  4U6W A;  2Q96 A;  1XGM A;  1PV9 A;  3MAT A;  4U69 A;  3IU7 A;  2Q93 A;  1B59 A;  4U1B A;  4RGZ 1;  1WL9 A;  2NQ7 A;  1QXW A;  3RVA A;  2BHA A;  2P99 A;  4Z7M A;  3L24 A;  4FUK A;  2Q8K A;  2GG2 A;  4IKT A;  2BH3 A;  1CHM A;  1WN1 A;  2GG8 A;  5JFR A;  4IKS A;  4IPA A;  2OKN A;  5CDE A;  2HOW A;  2MAT A;  4MAT A;  4FKC A;  4ZNG A;  3IU8 A;  1C23 A;  1R5H A;  1MAT A;  5D6E A;  2BN7 A;  3PKA A;  3PKC A;  4U71 A;  4A6W A;  1WLR A;  1XGN A;  4U6C A;  4U70 A;  1YW7 A;  1XNZ A;  4FLL A;  4IF7 A;  2EVO A;  2GU6 A;  3BIP A;  1XGS A;  3FMQ A;  4FLK A;  3S6B A;  4R60 A;  1R58 A;  5D6F A;  2B3L A;  1B6A A;  2BWY A;  2P98 A;  1W2M A;  4PV4 A;  1N51 A;  3IU9 A;  2GZ5 A;  3PKD A;  4OOK A;  5FCH A;  4RZY A;  2GU5 A;  2BWS A;  1A16 A;  1YVM A;  4ZWO A;  1O0X A;  1QZY A;  4PNC A;  4FLJ A;  1C24 A;  4JUQ A;  2BHB A;  3D27 A;  2GG5 A;  3FMR A;  2BHC A;  1KP0 A;  1JAW A;  3IG4 A;  2P9A A;  5CNX A;  2BWX A;  2B3K A;  2ADU A;  2IW2 A;  1WBQ A;  1YW8 A;  4IKU A;  2NQ6 A;  2V3Z A;  4S00 A;  1C22 A;  4FO8 A;  2GG0 A;  1C27 A;  1WL6 A;  2GA2 A;  2OAZ A;  1KQ9 A;  4FO7 A;  4RZZ A;  3TAV A;  4U75 A;  2BHD A;  3FM3 A;  4U6Z A;  4FLI A;  4U73 A;  3BIT A;  4A6V A;  2BWU A;  3TB5 A;  2GG9 A;  1WY2 A;  2EA2 A;  1XGO A;  4U6E A;  1YW9 A;  2GU7 A;  4ZWP A;  1YJ3 A;  4IDY A;  3MR1 A;  1WKM A;  5CE6 A;  3CB6 A;  2V3X A;  2Q92 A;  3CTZ A;  2V3Y A; 
#chains in the Genus database with same CATH topology
 2GG3 A;  4IKR A;  5JI6 A;  1W7V A;  3Q6D A;  1BOA A;  2GU4 A;  5CIK A;  2Q94 A;  1R5G A;  2B3H A;  4HXX A;  4IEC A;  4S01 A;  1KQ0 A;  4S2T P;  2EA4 A;  5CDL A;  2V6C A;  2EVM A;  4B28 A;  1QXZ A;  3PKB A;  1C21 A;  3PKE A;  2BWW A;  4EGE A;  2G6P A;  5JHU A;  3MX6 A;  5E5B A;  2EVC A;  4ZWU A;  3BIQ A;  2GGB A;  4U6J A;  5CDV A;  2GG7 A;  1QXY A;  2BB7 A;  4KM3 A;  2BWV A;  1BN5 A;  2GTX A;  1M35 A;  2GGC A;  3CB5 A;  4IU6 A;  4S2R P;  5CLS A;  3ROR A;  2DFI A;  5FCF A;  4QR8 A;  1Y1N A;  3L7G A;  2ZSG A;  2Q95 A;  4U76 A;  2BWT A;  4U6W A;  2Q96 A;  1XGM A;  1PV9 A;  3MAT A;  4U69 A;  3IU7 A;  2Q93 A;  1B59 A;  4U1B A;  4RGZ 1;  1WL9 A;  2NQ7 A;  1QXW A;  3RVA A;  2BHA A;  2P99 A;  4Z7M A;  3L24 A;  4FUK A;  2Q8K A;  2GG2 A;  4IKT A;  2BH3 A;  1CHM A;  1WN1 A;  2GG8 A;  5JFR A;  4IKS A;  4IPA A;  2OKN A;  5CDE A;  2HOW A;  2MAT A;  4MAT A;  4FKC A;  4ZNG A;  3IU8 A;  1C23 A;  1R5H A;  1MAT A;  5D6E A;  2BN7 A;  3PKA A;  3PKC A;  4U71 A;  4A6W A;  1WLR A;  1XGN A;  4U6C A;  4U70 A;  1YW7 A;  1XNZ A;  4FLL A;  4IF7 A;  2EVO A;  2GU6 A;  3BIP A;  1XGS A;  3FMQ A;  4FLK A;  3S6B A;  4R60 A;  1R58 A;  5D6F A;  2B3L A;  1B6A A;  2BWY A;  2P98 A;  1W2M A;  4PV4 A;  1N51 A;  3IU9 A;  2GZ5 A;  3PKD A;  4OOK A;  5FCH A;  4RZY A;  2GU5 A;  2BWS A;  1A16 A;  1YVM A;  4ZWO A;  1O0X A;  1QZY A;  4PNC A;  4FLJ A;  1C24 A;  4JUQ A;  2BHB A;  3D27 A;  2GG5 A;  3FMR A;  2BHC A;  1KP0 A;  1JAW A;  3IG4 A;  2P9A A;  5CNX A;  2BWX A;  2B3K A;  2ADU A;  2IW2 A;  1WBQ A;  1YW8 A;  4IKU A;  2NQ6 A;  2V3Z A;  4S00 A;  1C22 A;  4FO8 A;  2GG0 A;  1C27 A;  1WL6 A;  2GA2 A;  2OAZ A;  1KQ9 A;  4FO7 A;  4RZZ A;  3TAV A;  4U75 A;  2BHD A;  3FM3 A;  4U6Z A;  4FLI A;  4U73 A;  3BIT A;  4A6V A;  2BWU A;  3TB5 A;  2GG9 A;  1WY2 A;  2EA2 A;  1XGO A;  4U6E A;  1YW9 A;  2GU7 A;  4ZWP A;  1YJ3 A;  4IDY A;  3MR1 A;  1WKM A;  5CE6 A;  3CB6 A;  2V3X A;  2Q92 A;  3CTZ A;  2V3Y A; 
#chains in the Genus database with same CATH homology
 2GG3 A;  4IKR A;  5JI6 A;  1W7V A;  3Q6D A;  1BOA A;  2GU4 A;  5CIK A;  2Q94 A;  1R5G A;  2B3H A;  4HXX A;  4IEC A;  4S01 A;  1KQ0 A;  4S2T P;  2EA4 A;  5CDL A;  2V6C A;  2EVM A;  4B28 A;  1QXZ A;  3PKB A;  1C21 A;  3PKE A;  2BWW A;  4EGE A;  2G6P A;  5JHU A;  3MX6 A;  5E5B A;  2EVC A;  4ZWU A;  3BIQ A;  2GGB A;  4U6J A;  5CDV A;  2GG7 A;  1QXY A;  2BB7 A;  4KM3 A;  2BWV A;  1BN5 A;  2GTX A;  1M35 A;  2GGC A;  3CB5 A;  4IU6 A;  4S2R P;  5CLS A;  3ROR A;  2DFI A;  5FCF A;  4QR8 A;  1Y1N A;  3L7G A;  2ZSG A;  2Q95 A;  4U76 A;  2BWT A;  4U6W A;  2Q96 A;  1XGM A;  1PV9 A;  3MAT A;  4U69 A;  3IU7 A;  2Q93 A;  1B59 A;  4U1B A;  4RGZ 1;  1WL9 A;  2NQ7 A;  1QXW A;  3RVA A;  2BHA A;  2P99 A;  4Z7M A;  3L24 A;  4FUK A;  2Q8K A;  2GG2 A;  4IKT A;  2BH3 A;  1CHM A;  1WN1 A;  2GG8 A;  5JFR A;  4IKS A;  4IPA A;  2OKN A;  5CDE A;  2HOW A;  2MAT A;  4MAT A;  4FKC A;  4ZNG A;  3IU8 A;  1C23 A;  1R5H A;  1MAT A;  5D6E A;  2BN7 A;  3PKA A;  3PKC A;  4U71 A;  4A6W A;  1WLR A;  1XGN A;  4U6C A;  4U70 A;  1YW7 A;  1XNZ A;  4FLL A;  4IF7 A;  2EVO A;  2GU6 A;  3BIP A;  1XGS A;  3FMQ A;  4FLK A;  3S6B A;  4R60 A;  1R58 A;  5D6F A;  2B3L A;  1B6A A;  2BWY A;  2P98 A;  1W2M A;  4PV4 A;  1N51 A;  3IU9 A;  2GZ5 A;  3PKD A;  4OOK A;  5FCH A;  4RZY A;  2GU5 A;  2BWS A;  1A16 A;  1YVM A;  4ZWO A;  1O0X A;  1QZY A;  4PNC A;  4FLJ A;  1C24 A;  4JUQ A;  2BHB A;  3D27 A;  2GG5 A;  3FMR A;  2BHC A;  1KP0 A;  1JAW A;  3IG4 A;  2P9A A;  5CNX A;  2BWX A;  2B3K A;  2ADU A;  2IW2 A;  1WBQ A;  1YW8 A;  4IKU A;  2NQ6 A;  2V3Z A;  4S00 A;  1C22 A;  4FO8 A;  2GG0 A;  1C27 A;  1WL6 A;  2GA2 A;  2OAZ A;  1KQ9 A;  4FO7 A;  4RZZ A;  3TAV A;  4U75 A;  2BHD A;  3FM3 A;  4U6Z A;  4FLI A;  4U73 A;  3BIT A;  4A6V A;  2BWU A;  3TB5 A;  2GG9 A;  1WY2 A;  2EA2 A;  1XGO A;  4U6E A;  1YW9 A;  2GU7 A;  4ZWP A;  1YJ3 A;  4IDY A;  3MR1 A;  1WKM A;  5CE6 A;  3CB6 A;  2V3X A;  2Q92 A;  3CTZ A;  2V3Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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