4IF7A

Mycobacterium tuberculosis methionine aminopeptidase type 1c in complex with homocysteine-methyl disulfide
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
281
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
total genus 86
structure length 281
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4if7A01
1XGNA 2Q93A 3RVAA 5CNXA 4U6WA 1WL9A 1KQ0A 4EGEA 3CB6A 4R60A 4U6EA 3IG4A 2BHBA 2G6PA 2ZSGA 2GG2A 1BN5A 2B3KA 2GU7A 4U76A 2Q95A 4S2TP 4IKSA 4IECA 3MX6A 5E5BA 1XGMA 5CDVA 3IU7A 2BH3A 3FMRA 4S01A 1YW9A 1C22A 2EVOA 2GGCA 4IPAA 4U6JA 2GU4A 3Q6DA 4RZYA 4ZNGA 1W2MA 1C27A 2V3ZA 3D27A 3TAVA 5CIKA 1C23A 2P9AA 1WL6A 4IU6A 2GG0A 4JUQA 2EA2A 2GG3A 4FO7A 2BWXA 4U6CA 4S00A 2DFIA 1QXWA 2IW2A 4RGZ1 2B3LA 2B3HA 4FLJA 4FLKA 5D6FA 2GG9A 4U1BA 2EA4A 3IU9A 1JAWA 4U70A 2BHCA 3TB5A 3PKCA 2GTXA 3CTZA 4OOKA 4A6VA 4A6WA 4ZWUA 2BWSA 1BOAA 4IF7A 2MATA 2GGBA 2BWVA 4IKUA 4FKCA 2V6CA 2Q94A 2P99A 3PKBA 3PKEA 4U71A 2Q92A 1A16A 2HOWA 2Q8KA 2BWUA 2GA2A 3PKDA 4ZWOA 2GG5A 5FCFA 2BWWA 2BB7A 1R5HA 1B6AA 4U69A 1R5GA 4Z7MA 4S2RP 4B28A 1R58A 5JHUA 1PV9A 2BHAA 4FLLA 2GU6A 5JI6A 4IKRA 4PV4A 4FO8A 2NQ6A 3L24A 1XGSA 3BITA 3L7GA 4IDYA 3PKAA 2V3XA 1WBQA 3MATA 4FLIA 4IKTA 5CLSA 1C24A 5JFRA 1WN1A 2GU5A 2OKNA 1KP0A 3FM3A 2BN7A 5CE6A 4U6ZA 1W7VA 3IU8A 5D6EA 3FMQA 3BIQA 4U75A 1WLRA 3RORA 1C21A 1N51A 1QXYA 2V3YA 4HXXA 2ADUA 1YVMA 1XNZA 4RZZA 3MR1A 1O0XA 5CDEA 2GG7A 4PNCA 1YJ3A 2BHDA 1YW7A 3CB5A 2GG8A 5FCHA 4MATA 2Q96A 3BIPA 1WY2A 4U73A 2GZ5A 4ZWPA 1WKMA 1QXZA 5CDLA 2EVMA 1M35A 2BWTA 2EVCA 1B59A 1YW8A 1Y1NA 2NQ7A 4FUKA 4QR8A 1CHMA 2OAZA 3S6BA 2P98A 4KM3A 1XGOA 1KQ9A 2BWYA 1QZYA 1MATA
chains in the Genus database with same CATH superfamily
1XGNA 2Q93A 3RVAA 5CNXA 4U6WA 1WL9A 1KQ0A 4EGEA 3CB6A 4R60A 4U6EA 3IG4A 2BHBA 2G6PA 2ZSGA 2GG2A 1BN5A 2B3KA 2GU7A 4U76A 2Q95A 4S2TP 4IKSA 4IECA 3MX6A 5E5BA 1XGMA 5CDVA 3IU7A 2BH3A 3FMRA 4S01A 1YW9A 1C22A 2EVOA 2GGCA 4IPAA 4U6JA 2GU4A 3Q6DA 4RZYA 4ZNGA 1W2MA 1C27A 2V3ZA 3D27A 3TAVA 5CIKA 1C23A 2P9AA 1WL6A 4IU6A 2GG0A 4JUQA 2EA2A 2GG3A 4FO7A 2BWXA 4U6CA 4S00A 2DFIA 1QXWA 2IW2A 4RGZ1 2B3LA 2B3HA 4FLJA 4FLKA 5D6FA 2GG9A 4U1BA 2EA4A 3IU9A 1JAWA 4U70A 2BHCA 3TB5A 3PKCA 2GTXA 3CTZA 4OOKA 4A6VA 4A6WA 4ZWUA 2BWSA 1BOAA 4IF7A 2MATA 2GGBA 2BWVA 4IKUA 4FKCA 2V6CA 2Q94A 2P99A 3PKBA 3PKEA 4U71A 2Q92A 1A16A 2HOWA 2Q8KA 2BWUA 2GA2A 3PKDA 4ZWOA 2GG5A 5FCFA 2BWWA 2BB7A 1R5HA 1B6AA 4U69A 1R5GA 4Z7MA 4S2RP 4B28A 1R58A 5JHUA 1PV9A 2BHAA 4FLLA 2GU6A 5JI6A 4IKRA 4PV4A 4FO8A 2NQ6A 3L24A 1XGSA 3BITA 3L7GA 4IDYA 3PKAA 2V3XA 1WBQA 3MATA 4FLIA 4IKTA 5CLSA 1C24A 5JFRA 1WN1A 2GU5A 2OKNA 1KP0A 3FM3A 2BN7A 5CE6A 4U6ZA 1W7VA 3IU8A 5D6EA 3FMQA 3BIQA 4U75A 1WLRA 3RORA 1C21A 1N51A 1QXYA 2V3YA 4HXXA 2ADUA 1YVMA 1XNZA 4RZZA 3MR1A 1O0XA 5CDEA 2GG7A 4PNCA 1YJ3A 2BHDA 1YW7A 3CB5A 2GG8A 5FCHA 4MATA 2Q96A 3BIPA 1WY2A 4U73A 2GZ5A 4ZWPA 1WKMA 1QXZA 5CDLA 2EVMA 1M35A 2BWTA 2EVCA 1B59A 1YW8A 1Y1NA 2NQ7A 4FUKA 4QR8A 1CHMA 2OAZA 3S6BA 2P98A 4KM3A 1XGOA 1KQ9A 2BWYA 1QZYA 1MATA
chains in the Genus database with same CATH topology
1XGNA 2Q93A 3RVAA 5CNXA 4U6WA 1WL9A 1KQ0A 4EGEA 3CB6A 4R60A 4U6EA 3IG4A 2BHBA 2G6PA 2ZSGA 2GG2A 1BN5A 2B3KA 2GU7A 4U76A 2Q95A 4S2TP 4IKSA 4IECA 3MX6A 5E5BA 1XGMA 5CDVA 3IU7A 2BH3A 3FMRA 4S01A 1YW9A 1C22A 2EVOA 2GGCA 4IPAA 4U6JA 2GU4A 3Q6DA 4RZYA 4ZNGA 1W2MA 1C27A 2V3ZA 3D27A 3TAVA 5CIKA 1C23A 2P9AA 1WL6A 4IU6A 2GG0A 4JUQA 2EA2A 2GG3A 4FO7A 2BWXA 4U6CA 4S00A 2DFIA 1QXWA 2IW2A 4RGZ1 2B3LA 2B3HA 4FLJA 4FLKA 5D6FA 2GG9A 4U1BA 2EA4A 3IU9A 1JAWA 4U70A 2BHCA 3TB5A 3PKCA 2GTXA 3CTZA 4OOKA 4A6VA 4A6WA 4ZWUA 2BWSA 1BOAA 4IF7A 2MATA 2GGBA 2BWVA 4IKUA 4FKCA 2V6CA 2Q94A 2P99A 3PKBA 3PKEA 4U71A 2Q92A 1A16A 2HOWA 2Q8KA 2BWUA 2GA2A 3PKDA 4ZWOA 2GG5A 5FCFA 2BWWA 2BB7A 1R5HA 1B6AA 4U69A 1R5GA 4Z7MA 4S2RP 4B28A 1R58A 5JHUA 1PV9A 2BHAA 4FLLA 2GU6A 5JI6A 4IKRA 4PV4A 4FO8A 2NQ6A 3L24A 1XGSA 3BITA 3L7GA 4IDYA 3PKAA 2V3XA 1WBQA 3MATA 4FLIA 4IKTA 5CLSA 1C24A 5JFRA 1WN1A 2GU5A 2OKNA 1KP0A 3FM3A 2BN7A 5CE6A 4U6ZA 1W7VA 3IU8A 5D6EA 3FMQA 3BIQA 4U75A 1WLRA 3RORA 1C21A 1N51A 1QXYA 2V3YA 4HXXA 2ADUA 1YVMA 1XNZA 4RZZA 3MR1A 1O0XA 5CDEA 2GG7A 4PNCA 1YJ3A 2BHDA 1YW7A 3CB5A 2GG8A 5FCHA 4MATA 2Q96A 3BIPA 1WY2A 4U73A 2GZ5A 4ZWPA 1WKMA 1QXZA 5CDLA 2EVMA 1M35A 2BWTA 2EVCA 1B59A 1YW8A 1Y1NA 2NQ7A 4FUKA 4QR8A 1CHMA 2OAZA 3S6BA 2P98A 4KM3A 1XGOA 1KQ9A 2BWYA 1QZYA 1MATA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XGN A;  2Q93 A;  3RVA A;  5CNX A;  4U6W A;  1WL9 A;  1KQ0 A;  4EGE A;  3CB6 A;  4R60 A;  4U6E A;  3IG4 A;  2BHB A;  2G6P A;  2ZSG A;  2GG2 A;  1BN5 A;  2B3K A;  2GU7 A;  4U76 A;  2Q95 A;  4S2T P;  4IKS A;  4IEC A;  3MX6 A;  5E5B A;  1XGM A;  5CDV A;  3IU7 A;  2BH3 A;  3FMR A;  4S01 A;  1YW9 A;  1C22 A;  2EVO A;  2GGC A;  4IPA A;  4U6J A;  2GU4 A;  3Q6D A;  4RZY A;  4ZNG A;  1W2M A;  1C27 A;  2V3Z A;  3D27 A;  3TAV A;  5CIK A;  1C23 A;  2P9A A;  1WL6 A;  4IU6 A;  2GG0 A;  4JUQ A;  2EA2 A;  2GG3 A;  4FO7 A;  2BWX A;  4U6C A;  4S00 A;  2DFI A;  1QXW A;  2IW2 A;  4RGZ 1;  2B3L A;  2B3H A;  4FLJ A;  4FLK A;  5D6F A;  2GG9 A;  4U1B A;  2EA4 A;  3IU9 A;  1JAW A;  4U70 A;  2BHC A;  3TB5 A;  3PKC A;  2GTX A;  3CTZ A;  4OOK A;  4A6V A;  4A6W A;  4ZWU A;  2BWS A;  1BOA A;  4IF7 A;  2MAT A;  2GGB A;  2BWV A;  4IKU A;  4FKC A;  2V6C A;  2Q94 A;  2P99 A;  3PKB A;  3PKE A;  4U71 A;  2Q92 A;  1A16 A;  2HOW A;  2Q8K A;  2BWU A;  2GA2 A;  3PKD A;  4ZWO A;  2GG5 A;  5FCF A;  2BWW A;  2BB7 A;  1R5H A;  1B6A A;  4U69 A;  1R5G A;  4Z7M A;  4S2R P;  4B28 A;  1R58 A;  5JHU A;  1PV9 A;  2BHA A;  4FLL A;  2GU6 A;  5JI6 A;  4IKR A;  4PV4 A;  4FO8 A;  2NQ6 A;  3L24 A;  1XGS A;  3BIT A;  3L7G A;  4IDY A;  3PKA A;  2V3X A;  1WBQ A;  3MAT A;  4FLI A;  4IKT A;  5CLS A;  1C24 A;  5JFR A;  1WN1 A;  2GU5 A;  2OKN A;  1KP0 A;  3FM3 A;  2BN7 A;  5CE6 A;  4U6Z A;  1W7V A;  3IU8 A;  5D6E A;  3FMQ A;  3BIQ A;  4U75 A;  1WLR A;  3ROR A;  1C21 A;  1N51 A;  1QXY A;  2V3Y A;  4HXX A;  2ADU A;  1YVM A;  1XNZ A;  4RZZ A;  3MR1 A;  1O0X A;  5CDE A;  2GG7 A;  4PNC A;  1YJ3 A;  2BHD A;  1YW7 A;  3CB5 A;  2GG8 A;  5FCH A;  4MAT A;  2Q96 A;  3BIP A;  1WY2 A;  4U73 A;  2GZ5 A;  4ZWP A;  1WKM A;  1QXZ A;  5CDL A;  2EVM A;  1M35 A;  2BWT A;  2EVC A;  1B59 A;  1YW8 A;  1Y1N A;  2NQ7 A;  4FUK A;  4QR8 A;  1CHM A;  2OAZ A;  3S6B A;  2P98 A;  4KM3 A;  1XGO A;  1KQ9 A;  2BWY A;  1QZY A;  1MAT A; 
#chains in the Genus database with same CATH topology
 1XGN A;  2Q93 A;  3RVA A;  5CNX A;  4U6W A;  1WL9 A;  1KQ0 A;  4EGE A;  3CB6 A;  4R60 A;  4U6E A;  3IG4 A;  2BHB A;  2G6P A;  2ZSG A;  2GG2 A;  1BN5 A;  2B3K A;  2GU7 A;  4U76 A;  2Q95 A;  4S2T P;  4IKS A;  4IEC A;  3MX6 A;  5E5B A;  1XGM A;  5CDV A;  3IU7 A;  2BH3 A;  3FMR A;  4S01 A;  1YW9 A;  1C22 A;  2EVO A;  2GGC A;  4IPA A;  4U6J A;  2GU4 A;  3Q6D A;  4RZY A;  4ZNG A;  1W2M A;  1C27 A;  2V3Z A;  3D27 A;  3TAV A;  5CIK A;  1C23 A;  2P9A A;  1WL6 A;  4IU6 A;  2GG0 A;  4JUQ A;  2EA2 A;  2GG3 A;  4FO7 A;  2BWX A;  4U6C A;  4S00 A;  2DFI A;  1QXW A;  2IW2 A;  4RGZ 1;  2B3L A;  2B3H A;  4FLJ A;  4FLK A;  5D6F A;  2GG9 A;  4U1B A;  2EA4 A;  3IU9 A;  1JAW A;  4U70 A;  2BHC A;  3TB5 A;  3PKC A;  2GTX A;  3CTZ A;  4OOK A;  4A6V A;  4A6W A;  4ZWU A;  2BWS A;  1BOA A;  4IF7 A;  2MAT A;  2GGB A;  2BWV A;  4IKU A;  4FKC A;  2V6C A;  2Q94 A;  2P99 A;  3PKB A;  3PKE A;  4U71 A;  2Q92 A;  1A16 A;  2HOW A;  2Q8K A;  2BWU A;  2GA2 A;  3PKD A;  4ZWO A;  2GG5 A;  5FCF A;  2BWW A;  2BB7 A;  1R5H A;  1B6A A;  4U69 A;  1R5G A;  4Z7M A;  4S2R P;  4B28 A;  1R58 A;  5JHU A;  1PV9 A;  2BHA A;  4FLL A;  2GU6 A;  5JI6 A;  4IKR A;  4PV4 A;  4FO8 A;  2NQ6 A;  3L24 A;  1XGS A;  3BIT A;  3L7G A;  4IDY A;  3PKA A;  2V3X A;  1WBQ A;  3MAT A;  4FLI A;  4IKT A;  5CLS A;  1C24 A;  5JFR A;  1WN1 A;  2GU5 A;  2OKN A;  1KP0 A;  3FM3 A;  2BN7 A;  5CE6 A;  4U6Z A;  1W7V A;  3IU8 A;  5D6E A;  3FMQ A;  3BIQ A;  4U75 A;  1WLR A;  3ROR A;  1C21 A;  1N51 A;  1QXY A;  2V3Y A;  4HXX A;  2ADU A;  1YVM A;  1XNZ A;  4RZZ A;  3MR1 A;  1O0X A;  5CDE A;  2GG7 A;  4PNC A;  1YJ3 A;  2BHD A;  1YW7 A;  3CB5 A;  2GG8 A;  5FCH A;  4MAT A;  2Q96 A;  3BIP A;  1WY2 A;  4U73 A;  2GZ5 A;  4ZWP A;  1WKM A;  1QXZ A;  5CDL A;  2EVM A;  1M35 A;  2BWT A;  2EVC A;  1B59 A;  1YW8 A;  1Y1N A;  2NQ7 A;  4FUK A;  4QR8 A;  1CHM A;  2OAZ A;  3S6B A;  2P98 A;  4KM3 A;  1XGO A;  1KQ9 A;  2BWY A;  1QZY A;  1MAT A; 
#chains in the Genus database with same CATH homology
 1XGN A;  2Q93 A;  3RVA A;  5CNX A;  4U6W A;  1WL9 A;  1KQ0 A;  4EGE A;  3CB6 A;  4R60 A;  4U6E A;  3IG4 A;  2BHB A;  2G6P A;  2ZSG A;  2GG2 A;  1BN5 A;  2B3K A;  2GU7 A;  4U76 A;  2Q95 A;  4S2T P;  4IKS A;  4IEC A;  3MX6 A;  5E5B A;  1XGM A;  5CDV A;  3IU7 A;  2BH3 A;  3FMR A;  4S01 A;  1YW9 A;  1C22 A;  2EVO A;  2GGC A;  4IPA A;  4U6J A;  2GU4 A;  3Q6D A;  4RZY A;  4ZNG A;  1W2M A;  1C27 A;  2V3Z A;  3D27 A;  3TAV A;  5CIK A;  1C23 A;  2P9A A;  1WL6 A;  4IU6 A;  2GG0 A;  4JUQ A;  2EA2 A;  2GG3 A;  4FO7 A;  2BWX A;  4U6C A;  4S00 A;  2DFI A;  1QXW A;  2IW2 A;  4RGZ 1;  2B3L A;  2B3H A;  4FLJ A;  4FLK A;  5D6F A;  2GG9 A;  4U1B A;  2EA4 A;  3IU9 A;  1JAW A;  4U70 A;  2BHC A;  3TB5 A;  3PKC A;  2GTX A;  3CTZ A;  4OOK A;  4A6V A;  4A6W A;  4ZWU A;  2BWS A;  1BOA A;  4IF7 A;  2MAT A;  2GGB A;  2BWV A;  4IKU A;  4FKC A;  2V6C A;  2Q94 A;  2P99 A;  3PKB A;  3PKE A;  4U71 A;  2Q92 A;  1A16 A;  2HOW A;  2Q8K A;  2BWU A;  2GA2 A;  3PKD A;  4ZWO A;  2GG5 A;  5FCF A;  2BWW A;  2BB7 A;  1R5H A;  1B6A A;  4U69 A;  1R5G A;  4Z7M A;  4S2R P;  4B28 A;  1R58 A;  5JHU A;  1PV9 A;  2BHA A;  4FLL A;  2GU6 A;  5JI6 A;  4IKR A;  4PV4 A;  4FO8 A;  2NQ6 A;  3L24 A;  1XGS A;  3BIT A;  3L7G A;  4IDY A;  3PKA A;  2V3X A;  1WBQ A;  3MAT A;  4FLI A;  4IKT A;  5CLS A;  1C24 A;  5JFR A;  1WN1 A;  2GU5 A;  2OKN A;  1KP0 A;  3FM3 A;  2BN7 A;  5CE6 A;  4U6Z A;  1W7V A;  3IU8 A;  5D6E A;  3FMQ A;  3BIQ A;  4U75 A;  1WLR A;  3ROR A;  1C21 A;  1N51 A;  1QXY A;  2V3Y A;  4HXX A;  2ADU A;  1YVM A;  1XNZ A;  4RZZ A;  3MR1 A;  1O0X A;  5CDE A;  2GG7 A;  4PNC A;  1YJ3 A;  2BHD A;  1YW7 A;  3CB5 A;  2GG8 A;  5FCH A;  4MAT A;  2Q96 A;  3BIP A;  1WY2 A;  4U73 A;  2GZ5 A;  4ZWP A;  1WKM A;  1QXZ A;  5CDL A;  2EVM A;  1M35 A;  2BWT A;  2EVC A;  1B59 A;  1YW8 A;  1Y1N A;  2NQ7 A;  4FUK A;  4QR8 A;  1CHM A;  2OAZ A;  3S6B A;  2P98 A;  4KM3 A;  1XGO A;  1KQ9 A;  2BWY A;  1QZY A;  1MAT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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