4IKTA

Crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with n1-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)-n2-(5-(trifluoromethyl)pyridin-2-yl)ethane-1,2-diamine
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4iktA00
1C21A 1B59A 4ZWOA 1YW8A 4JUQA 3FMQA 4HXXA 1W7VA 1W2MA 4FLLA 2GTXA 2BH3A 4U75A 5E5BA 4EGEA 4U71A 1QZYA 4S00A 4FLIA 5D6EA 1KQ9A 4ZWPA 5JHUA 5CIKA 2IW2A 1R5GA 4QR8A 4Z7MA 2GG0A 3BIQA 4FUKA 2BHDA 2EA4A 4U1BA 4ZNGA 3IG4A 2GU7A 1YJ3A 3L24A 1WKMA 3PKBA 2G6PA 4MATA 4IDYA 1WBQA 4IF7A 3BIPA 1KQ0A 3MATA 2P98A 4U69A 4IKUA 5D6FA 4IKSA 1MATA 1QXYA 4U6JA 2HOWA 2EVCA 2V3YA 2B3KA 1WL9A 4PNCA 1XNZA 2GGCA 2DFIA 5FCFA 3TAVA 4IKRA 1C27A 1PV9A 3FM3A 1XGSA 1WL6A 2ZSGA 3S6BA 4FO7A 5CDVA 4S2RP 4KM3A 1XGNA 3RVAA 2EA2A 1BN5A 3TB5A 5JFRA 1CHMA 2GG3A 4ZWUA 2BHBA 2Q93A 1O0XA 2Q96A 5CLSA 2P99A 4FLKA 4FO8A 4RGZ1 2Q94A 2BWXA 1YW9A 3CB5A 1N51A 1WLRA 4FLJA 2GG5A 2ADUA 1R5HA 5FCHA 2GU5A 1KP0A 2OAZA 4S2TP 4U6EA 4IPAA 4U70A 3MR1A 2GU6A 4RZYA 2BWSA 2MATA 2P9AA 3MX6A 4U6ZA 3CTZA 4RZZA 5JI6A 1BOAA 2GG2A 5CDEA 2GU4A 3D27A 2Q8KA 2EVOA 3PKDA 2GZ5A 2BWYA 4FKCA 5CE6A 1XGMA 2BHCA 2Q95A 2B3HA 3Q6DA 1WN1A 2BWWA 4U73A 4A6VA 4S01A 1YW7A 3IU9A 3IU7A 1A16A 2BWVA 2Q92A 2BB7A 5CNXA 2NQ7A 1QXWA 2EVMA 1C24A 4R60A 3CB6A 2GA2A 1XGOA 1JAWA 3PKEA 1YVMA 2GG8A 2V3ZA 3RORA 4U6CA 2B3LA 4B28A 1C22A 1R58A 4PV4A 4IKTA 1C23A 2BHAA 2BN7A 2BWUA 2GG7A 2NQ6A 3L7GA 3PKCA 4OOKA 2GG9A 2V3XA 1M35A 3IU8A 1B6AA 1QXZA 2GGBA 4A6WA 5CDLA 2OKNA 4U76A 2BWTA 4U6WA 3FMRA 2V6CA 4IU6A 3BITA 3PKAA 1Y1NA 1WY2A 4IECA
chains in the Genus database with same CATH superfamily
1C21A 1B59A 4ZWOA 1YW8A 4JUQA 3FMQA 4HXXA 1W7VA 1W2MA 4FLLA 2GTXA 2BH3A 4U75A 5E5BA 4EGEA 4U71A 1QZYA 4S00A 4FLIA 5D6EA 1KQ9A 4ZWPA 5JHUA 5CIKA 2IW2A 1R5GA 4QR8A 4Z7MA 2GG0A 3BIQA 4FUKA 2BHDA 2EA4A 4U1BA 4ZNGA 3IG4A 2GU7A 1YJ3A 3L24A 1WKMA 3PKBA 2G6PA 4MATA 4IDYA 1WBQA 4IF7A 3BIPA 1KQ0A 3MATA 2P98A 4U69A 4IKUA 5D6FA 4IKSA 1MATA 1QXYA 4U6JA 2HOWA 2EVCA 2V3YA 2B3KA 1WL9A 4PNCA 1XNZA 2GGCA 2DFIA 5FCFA 3TAVA 4IKRA 1C27A 1PV9A 3FM3A 1XGSA 1WL6A 2ZSGA 3S6BA 4FO7A 5CDVA 4S2RP 4KM3A 1XGNA 3RVAA 2EA2A 1BN5A 3TB5A 5JFRA 1CHMA 2GG3A 4ZWUA 2BHBA 2Q93A 1O0XA 2Q96A 5CLSA 2P99A 4FLKA 4FO8A 4RGZ1 2Q94A 2BWXA 1YW9A 3CB5A 1N51A 1WLRA 4FLJA 2GG5A 2ADUA 1R5HA 5FCHA 2GU5A 1KP0A 2OAZA 4S2TP 4U6EA 4IPAA 4U70A 3MR1A 2GU6A 4RZYA 2BWSA 2MATA 2P9AA 3MX6A 4U6ZA 3CTZA 4RZZA 5JI6A 1BOAA 2GG2A 5CDEA 2GU4A 3D27A 2Q8KA 2EVOA 3PKDA 2GZ5A 2BWYA 4FKCA 5CE6A 1XGMA 2BHCA 2Q95A 2B3HA 3Q6DA 1WN1A 2BWWA 4U73A 4A6VA 4S01A 1YW7A 3IU9A 3IU7A 1A16A 2BWVA 2Q92A 2BB7A 5CNXA 2NQ7A 1QXWA 2EVMA 1C24A 4R60A 3CB6A 2GA2A 1XGOA 1JAWA 3PKEA 1YVMA 2GG8A 2V3ZA 3RORA 4U6CA 2B3LA 4B28A 1C22A 1R58A 4PV4A 4IKTA 1C23A 2BHAA 2BN7A 2BWUA 2GG7A 2NQ6A 3L7GA 3PKCA 4OOKA 2GG9A 2V3XA 1M35A 3IU8A 1B6AA 1QXZA 2GGBA 4A6WA 5CDLA 2OKNA 4U76A 2BWTA 4U6WA 3FMRA 2V6CA 4IU6A 3BITA 3PKAA 1Y1NA 1WY2A 4IECA
chains in the Genus database with same CATH topology
1C21A 1B59A 4ZWOA 1YW8A 4JUQA 3FMQA 4HXXA 1W7VA 1W2MA 4FLLA 2GTXA 2BH3A 4U75A 5E5BA 4EGEA 4U71A 1QZYA 4S00A 4FLIA 5D6EA 1KQ9A 4ZWPA 5JHUA 5CIKA 2IW2A 1R5GA 4QR8A 4Z7MA 2GG0A 3BIQA 4FUKA 2BHDA 2EA4A 4U1BA 4ZNGA 3IG4A 2GU7A 1YJ3A 3L24A 1WKMA 3PKBA 2G6PA 4MATA 4IDYA 1WBQA 4IF7A 3BIPA 1KQ0A 3MATA 2P98A 4U69A 4IKUA 5D6FA 4IKSA 1MATA 1QXYA 4U6JA 2HOWA 2EVCA 2V3YA 2B3KA 1WL9A 4PNCA 1XNZA 2GGCA 2DFIA 5FCFA 3TAVA 4IKRA 1C27A 1PV9A 3FM3A 1XGSA 1WL6A 2ZSGA 3S6BA 4FO7A 5CDVA 4S2RP 4KM3A 1XGNA 3RVAA 2EA2A 1BN5A 3TB5A 5JFRA 1CHMA 2GG3A 4ZWUA 2BHBA 2Q93A 1O0XA 2Q96A 5CLSA 2P99A 4FLKA 4FO8A 4RGZ1 2Q94A 2BWXA 1YW9A 3CB5A 1N51A 1WLRA 4FLJA 2GG5A 2ADUA 1R5HA 5FCHA 2GU5A 1KP0A 2OAZA 4S2TP 4U6EA 4IPAA 4U70A 3MR1A 2GU6A 4RZYA 2BWSA 2MATA 2P9AA 3MX6A 4U6ZA 3CTZA 4RZZA 5JI6A 1BOAA 2GG2A 5CDEA 2GU4A 3D27A 2Q8KA 2EVOA 3PKDA 2GZ5A 2BWYA 4FKCA 5CE6A 1XGMA 2BHCA 2Q95A 2B3HA 3Q6DA 1WN1A 2BWWA 4U73A 4A6VA 4S01A 1YW7A 3IU9A 3IU7A 1A16A 2BWVA 2Q92A 2BB7A 5CNXA 2NQ7A 1QXWA 2EVMA 1C24A 4R60A 3CB6A 2GA2A 1XGOA 1JAWA 3PKEA 1YVMA 2GG8A 2V3ZA 3RORA 4U6CA 2B3LA 4B28A 1C22A 1R58A 4PV4A 4IKTA 1C23A 2BHAA 2BN7A 2BWUA 2GG7A 2NQ6A 3L7GA 3PKCA 4OOKA 2GG9A 2V3XA 1M35A 3IU8A 1B6AA 1QXZA 2GGBA 4A6WA 5CDLA 2OKNA 4U76A 2BWTA 4U6WA 3FMRA 2V6CA 4IU6A 3BITA 3PKAA 1Y1NA 1WY2A 4IECA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C21 A;  1B59 A;  4ZWO A;  1YW8 A;  4JUQ A;  3FMQ A;  4HXX A;  1W7V A;  1W2M A;  4FLL A;  2GTX A;  2BH3 A;  4U75 A;  5E5B A;  4EGE A;  4U71 A;  1QZY A;  4S00 A;  4FLI A;  5D6E A;  1KQ9 A;  4ZWP A;  5JHU A;  5CIK A;  2IW2 A;  1R5G A;  4QR8 A;  4Z7M A;  2GG0 A;  3BIQ A;  4FUK A;  2BHD A;  2EA4 A;  4U1B A;  4ZNG A;  3IG4 A;  2GU7 A;  1YJ3 A;  3L24 A;  1WKM A;  3PKB A;  2G6P A;  4MAT A;  4IDY A;  1WBQ A;  4IF7 A;  3BIP A;  1KQ0 A;  3MAT A;  2P98 A;  4U69 A;  4IKU A;  5D6F A;  4IKS A;  1MAT A;  1QXY A;  4U6J A;  2HOW A;  2EVC A;  2V3Y A;  2B3K A;  1WL9 A;  4PNC A;  1XNZ A;  2GGC A;  2DFI A;  5FCF A;  3TAV A;  4IKR A;  1C27 A;  1PV9 A;  3FM3 A;  1XGS A;  1WL6 A;  2ZSG A;  3S6B A;  4FO7 A;  5CDV A;  4S2R P;  4KM3 A;  1XGN A;  3RVA A;  2EA2 A;  1BN5 A;  3TB5 A;  5JFR A;  1CHM A;  2GG3 A;  4ZWU A;  2BHB A;  2Q93 A;  1O0X A;  2Q96 A;  5CLS A;  2P99 A;  4FLK A;  4FO8 A;  4RGZ 1;  2Q94 A;  2BWX A;  1YW9 A;  3CB5 A;  1N51 A;  1WLR A;  4FLJ A;  2GG5 A;  2ADU A;  1R5H A;  5FCH A;  2GU5 A;  1KP0 A;  2OAZ A;  4S2T P;  4U6E A;  4IPA A;  4U70 A;  3MR1 A;  2GU6 A;  4RZY A;  2BWS A;  2MAT A;  2P9A A;  3MX6 A;  4U6Z A;  3CTZ A;  4RZZ A;  5JI6 A;  1BOA A;  2GG2 A;  5CDE A;  2GU4 A;  3D27 A;  2Q8K A;  2EVO A;  3PKD A;  2GZ5 A;  2BWY A;  4FKC A;  5CE6 A;  1XGM A;  2BHC A;  2Q95 A;  2B3H A;  3Q6D A;  1WN1 A;  2BWW A;  4U73 A;  4A6V A;  4S01 A;  1YW7 A;  3IU9 A;  3IU7 A;  1A16 A;  2BWV A;  2Q92 A;  2BB7 A;  5CNX A;  2NQ7 A;  1QXW A;  2EVM A;  1C24 A;  4R60 A;  3CB6 A;  2GA2 A;  1XGO A;  1JAW A;  3PKE A;  1YVM A;  2GG8 A;  2V3Z A;  3ROR A;  4U6C A;  2B3L A;  4B28 A;  1C22 A;  1R58 A;  4PV4 A;  4IKT A;  1C23 A;  2BHA A;  2BN7 A;  2BWU A;  2GG7 A;  2NQ6 A;  3L7G A;  3PKC A;  4OOK A;  2GG9 A;  2V3X A;  1M35 A;  3IU8 A;  1B6A A;  1QXZ A;  2GGB A;  4A6W A;  5CDL A;  2OKN A;  4U76 A;  2BWT A;  4U6W A;  3FMR A;  2V6C A;  4IU6 A;  3BIT A;  3PKA A;  1Y1N A;  1WY2 A;  4IEC A; 
#chains in the Genus database with same CATH topology
 1C21 A;  1B59 A;  4ZWO A;  1YW8 A;  4JUQ A;  3FMQ A;  4HXX A;  1W7V A;  1W2M A;  4FLL A;  2GTX A;  2BH3 A;  4U75 A;  5E5B A;  4EGE A;  4U71 A;  1QZY A;  4S00 A;  4FLI A;  5D6E A;  1KQ9 A;  4ZWP A;  5JHU A;  5CIK A;  2IW2 A;  1R5G A;  4QR8 A;  4Z7M A;  2GG0 A;  3BIQ A;  4FUK A;  2BHD A;  2EA4 A;  4U1B A;  4ZNG A;  3IG4 A;  2GU7 A;  1YJ3 A;  3L24 A;  1WKM A;  3PKB A;  2G6P A;  4MAT A;  4IDY A;  1WBQ A;  4IF7 A;  3BIP A;  1KQ0 A;  3MAT A;  2P98 A;  4U69 A;  4IKU A;  5D6F A;  4IKS A;  1MAT A;  1QXY A;  4U6J A;  2HOW A;  2EVC A;  2V3Y A;  2B3K A;  1WL9 A;  4PNC A;  1XNZ A;  2GGC A;  2DFI A;  5FCF A;  3TAV A;  4IKR A;  1C27 A;  1PV9 A;  3FM3 A;  1XGS A;  1WL6 A;  2ZSG A;  3S6B A;  4FO7 A;  5CDV A;  4S2R P;  4KM3 A;  1XGN A;  3RVA A;  2EA2 A;  1BN5 A;  3TB5 A;  5JFR A;  1CHM A;  2GG3 A;  4ZWU A;  2BHB A;  2Q93 A;  1O0X A;  2Q96 A;  5CLS A;  2P99 A;  4FLK A;  4FO8 A;  4RGZ 1;  2Q94 A;  2BWX A;  1YW9 A;  3CB5 A;  1N51 A;  1WLR A;  4FLJ A;  2GG5 A;  2ADU A;  1R5H A;  5FCH A;  2GU5 A;  1KP0 A;  2OAZ A;  4S2T P;  4U6E A;  4IPA A;  4U70 A;  3MR1 A;  2GU6 A;  4RZY A;  2BWS A;  2MAT A;  2P9A A;  3MX6 A;  4U6Z A;  3CTZ A;  4RZZ A;  5JI6 A;  1BOA A;  2GG2 A;  5CDE A;  2GU4 A;  3D27 A;  2Q8K A;  2EVO A;  3PKD A;  2GZ5 A;  2BWY A;  4FKC A;  5CE6 A;  1XGM A;  2BHC A;  2Q95 A;  2B3H A;  3Q6D A;  1WN1 A;  2BWW A;  4U73 A;  4A6V A;  4S01 A;  1YW7 A;  3IU9 A;  3IU7 A;  1A16 A;  2BWV A;  2Q92 A;  2BB7 A;  5CNX A;  2NQ7 A;  1QXW A;  2EVM A;  1C24 A;  4R60 A;  3CB6 A;  2GA2 A;  1XGO A;  1JAW A;  3PKE A;  1YVM A;  2GG8 A;  2V3Z A;  3ROR A;  4U6C A;  2B3L A;  4B28 A;  1C22 A;  1R58 A;  4PV4 A;  4IKT A;  1C23 A;  2BHA A;  2BN7 A;  2BWU A;  2GG7 A;  2NQ6 A;  3L7G A;  3PKC A;  4OOK A;  2GG9 A;  2V3X A;  1M35 A;  3IU8 A;  1B6A A;  1QXZ A;  2GGB A;  4A6W A;  5CDL A;  2OKN A;  4U76 A;  2BWT A;  4U6W A;  3FMR A;  2V6C A;  4IU6 A;  3BIT A;  3PKA A;  1Y1N A;  1WY2 A;  4IEC A; 
#chains in the Genus database with same CATH homology
 1C21 A;  1B59 A;  4ZWO A;  1YW8 A;  4JUQ A;  3FMQ A;  4HXX A;  1W7V A;  1W2M A;  4FLL A;  2GTX A;  2BH3 A;  4U75 A;  5E5B A;  4EGE A;  4U71 A;  1QZY A;  4S00 A;  4FLI A;  5D6E A;  1KQ9 A;  4ZWP A;  5JHU A;  5CIK A;  2IW2 A;  1R5G A;  4QR8 A;  4Z7M A;  2GG0 A;  3BIQ A;  4FUK A;  2BHD A;  2EA4 A;  4U1B A;  4ZNG A;  3IG4 A;  2GU7 A;  1YJ3 A;  3L24 A;  1WKM A;  3PKB A;  2G6P A;  4MAT A;  4IDY A;  1WBQ A;  4IF7 A;  3BIP A;  1KQ0 A;  3MAT A;  2P98 A;  4U69 A;  4IKU A;  5D6F A;  4IKS A;  1MAT A;  1QXY A;  4U6J A;  2HOW A;  2EVC A;  2V3Y A;  2B3K A;  1WL9 A;  4PNC A;  1XNZ A;  2GGC A;  2DFI A;  5FCF A;  3TAV A;  4IKR A;  1C27 A;  1PV9 A;  3FM3 A;  1XGS A;  1WL6 A;  2ZSG A;  3S6B A;  4FO7 A;  5CDV A;  4S2R P;  4KM3 A;  1XGN A;  3RVA A;  2EA2 A;  1BN5 A;  3TB5 A;  5JFR A;  1CHM A;  2GG3 A;  4ZWU A;  2BHB A;  2Q93 A;  1O0X A;  2Q96 A;  5CLS A;  2P99 A;  4FLK A;  4FO8 A;  4RGZ 1;  2Q94 A;  2BWX A;  1YW9 A;  3CB5 A;  1N51 A;  1WLR A;  4FLJ A;  2GG5 A;  2ADU A;  1R5H A;  5FCH A;  2GU5 A;  1KP0 A;  2OAZ A;  4S2T P;  4U6E A;  4IPA A;  4U70 A;  3MR1 A;  2GU6 A;  4RZY A;  2BWS A;  2MAT A;  2P9A A;  3MX6 A;  4U6Z A;  3CTZ A;  4RZZ A;  5JI6 A;  1BOA A;  2GG2 A;  5CDE A;  2GU4 A;  3D27 A;  2Q8K A;  2EVO A;  3PKD A;  2GZ5 A;  2BWY A;  4FKC A;  5CE6 A;  1XGM A;  2BHC A;  2Q95 A;  2B3H A;  3Q6D A;  1WN1 A;  2BWW A;  4U73 A;  4A6V A;  4S01 A;  1YW7 A;  3IU9 A;  3IU7 A;  1A16 A;  2BWV A;  2Q92 A;  2BB7 A;  5CNX A;  2NQ7 A;  1QXW A;  2EVM A;  1C24 A;  4R60 A;  3CB6 A;  2GA2 A;  1XGO A;  1JAW A;  3PKE A;  1YVM A;  2GG8 A;  2V3Z A;  3ROR A;  4U6C A;  2B3L A;  4B28 A;  1C22 A;  1R58 A;  4PV4 A;  4IKT A;  1C23 A;  2BHA A;  2BN7 A;  2BWU A;  2GG7 A;  2NQ6 A;  3L7G A;  3PKC A;  4OOK A;  2GG9 A;  2V3X A;  1M35 A;  3IU8 A;  1B6A A;  1QXZ A;  2GGB A;  4A6W A;  5CDL A;  2OKN A;  4U76 A;  2BWT A;  4U6W A;  3FMR A;  2V6C A;  4IU6 A;  3BIT A;  3PKA A;  1Y1N A;  1WY2 A;  4IEC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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