4ZWUA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f, v342l, i215y
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
sequence length
439
structure length
435
Chain Sequence
b'NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNYVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQLHDVGGFMADEQGAHQEPGHPFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ORGANOPHOSPHATE ANHYDROLASE/PROLIDASE
molecule tags Hydrolase
source organism Alteromonas sp.
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
total genus 154
structure length 435
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwuA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwuA02
3PKCA 2IW2A 5FCHA 2GU6A 2Q96A 5JFRA 4IDYA 4EGEA 4FLLA 1BN5A 3RORA 3FMRA 3IU9A 1W7VA 4B28A 5CDLA 3MATA 1YVMA 2V3ZA 1W2MA 2BH3A 1B59A 1KQ9A 4R60A 4U75A 2BWUA 1R5HA 5CNXA 3I7MA 4U73A 2MATA 3PKBA 1YW9A 2B3HA 2EA2A 4A6VA 3IG4A 4IKRA 2EVOA 3L7GA 2GG7A 4OOKA 2BWVA 1XGSA 4U1BA 1B6AA 2GGBA 1C23A 1YW7A 2BWWA 2P98A 4RZYA 2DFIA 4U6JA 1M35A 2BHAA 5E5BA 2BB7A 3PKEA 5CIKA 2BHCA 4U71A 2GZ5A 2BWYA 3BITA 2GG3A 4FLIA 3QOCA 2EA4A 2EVCA 2G6PA 4FO8A 1WY2A 1Y1NA 1C21A 1XGNA 3L24A 3PEBA 2V6CA 2GU5A 4FLKA 1R58A 2Q8KA 2GTXA 4KM3A 4U76A 3FMQA 1QXZA 1XGOA 4FKCA 3IU7A 2BHDA 5CDEA 2Q94A 2OAZA 4MATA 1WL6A 1C22A 4IECA 3IU8A 4ZWPA 2P9AA 3CTZA 1MATA 3OVKA 1O0XA 5E2CA 4PNCA 1QXYA 4RGZ1 1WBQA 3RVAA 1QZYA 1KP0A 4Z7MA 1N51A 3IL0A 4ZWUA 1XGMA 1YW8A 2B3KA 3Q6DA 3OOOA 3S6BA 1XNZA 4S01A 3PKDA 1QXWA 3BIQA 3CB6A 4IKSA 4PV4A 2GG0A 5D6FA 5CE6A 2EVMA 5CDVA 4ZNGA 5FCFA 3O5VA 5CLSA 2Q93A 4FO7A 2NQ6A 3FM3A 5JI6A 3MR1A 3TB5A 4U6EA 3D27A 4U6WA 2Q92A 1WL9A 4S2TP 4U6ZA 2GG2A 3MX6A 4JUQA 4FLJA 2V3XA 2ADUA 3PN9A 2GG5A 4IF7A 4QR8A 1C27A 1C24A 1WKMA 2HOWA 1KQ0A 5JHUA 4RZZA 2B3LA 4U6CA 2GA2A 4IKUA 1WN1A 3BIPA 3CB5A 4ZWOA 4IKTA 2BHBA 5D6EA 4IU6A 4FUKA 4HXXA 2NQ7A 2P99A 2GU4A 2BWTA 2GGCA 2GG9A 1WLRA 4U69A 2GG8A 2ZSGA 4U70A 4IPAA 1JAWA 2V3YA 2BN7A 1BOAA 2Q95A 2BWSA 1A16A 4S2RP 3PKAA 1PV9A 2OKNA 3TAVA 4A6WA 2GU7A 2BWXA 1R5GA 4S00A 1YJ3A 1CHMA
chains in the Genus database with same CATH superfamily
3PKCA 2IW2A 5FCHA 2GU6A 2Q96A 5JFRA 4IDYA 4EGEA 4FLLA 1BN5A 3RORA 3FMRA 3IU9A 1W7VA 4B28A 5CDLA 3MATA 1YVMA 2V3ZA 1W2MA 2BH3A 1B59A 1KQ9A 4R60A 4U75A 2BWUA 1R5HA 5CNXA 3I7MA 4U73A 2MATA 3PKBA 1YW9A 2B3HA 2EA2A 4A6VA 3IG4A 4IKRA 2EVOA 3L7GA 2GG7A 4OOKA 2BWVA 1XGSA 4U1BA 1B6AA 2GGBA 1C23A 1YW7A 2BWWA 2P98A 4RZYA 2DFIA 4U6JA 1M35A 2BHAA 5E5BA 2BB7A 3PKEA 5CIKA 2BHCA 4U71A 2GZ5A 2BWYA 3BITA 2GG3A 4FLIA 3QOCA 2EA4A 2EVCA 2G6PA 4FO8A 1WY2A 1Y1NA 1C21A 1XGNA 3L24A 3PEBA 2V6CA 2GU5A 4FLKA 1R58A 2Q8KA 2GTXA 4KM3A 4U76A 3FMQA 1QXZA 1XGOA 4FKCA 3IU7A 2BHDA 5CDEA 2Q94A 2OAZA 4MATA 1WL6A 1C22A 4IECA 3IU8A 4ZWPA 2P9AA 3CTZA 1MATA 3OVKA 1O0XA 5E2CA 4PNCA 1QXYA 4RGZ1 1WBQA 3RVAA 1QZYA 1KP0A 4Z7MA 1N51A 3IL0A 4ZWUA 1XGMA 1YW8A 2B3KA 3Q6DA 3OOOA 3S6BA 1XNZA 4S01A 3PKDA 1QXWA 3BIQA 3CB6A 4IKSA 4PV4A 2GG0A 5D6FA 5CE6A 2EVMA 5CDVA 4ZNGA 5FCFA 3O5VA 5CLSA 2Q93A 4FO7A 2NQ6A 3FM3A 5JI6A 3MR1A 3TB5A 4U6EA 3D27A 4U6WA 2Q92A 1WL9A 4S2TP 4U6ZA 2GG2A 3MX6A 4JUQA 4FLJA 2V3XA 2ADUA 3PN9A 2GG5A 4IF7A 4QR8A 1C27A 1C24A 1WKMA 2HOWA 1KQ0A 5JHUA 4RZZA 2B3LA 4U6CA 2GA2A 4IKUA 1WN1A 3BIPA 3CB5A 4ZWOA 4IKTA 2BHBA 5D6EA 4IU6A 4FUKA 4HXXA 2NQ7A 2P99A 2GU4A 2BWTA 2GGCA 2GG9A 1WLRA 4U69A 2GG8A 2ZSGA 4U70A 4IPAA 1JAWA 2V3YA 2BN7A 1BOAA 2Q95A 2BWSA 1A16A 4S2RP 3PKAA 1PV9A 2OKNA 3TAVA 4A6WA 2GU7A 2BWXA 1R5GA 4S00A 1YJ3A 1CHMA
chains in the Genus database with same CATH topology
3PKCA 2IW2A 5FCHA 2GU6A 2Q96A 5JFRA 4IDYA 4EGEA 4FLLA 1BN5A 3RORA 3FMRA 3IU9A 1W7VA 4B28A 5CDLA 3MATA 1YVMA 2V3ZA 1W2MA 2BH3A 1B59A 1KQ9A 4R60A 4U75A 2BWUA 1R5HA 5CNXA 3I7MA 4U73A 2MATA 3PKBA 1YW9A 2B3HA 2EA2A 4A6VA 3IG4A 4IKRA 2EVOA 3L7GA 2GG7A 4OOKA 2BWVA 1XGSA 4U1BA 1B6AA 2GGBA 1C23A 1YW7A 2BWWA 2P98A 4RZYA 2DFIA 4U6JA 1M35A 2BHAA 5E5BA 2BB7A 3PKEA 5CIKA 2BHCA 4U71A 2GZ5A 2BWYA 3BITA 2GG3A 4FLIA 3QOCA 2EA4A 2EVCA 2G6PA 4FO8A 1WY2A 1Y1NA 1C21A 1XGNA 3L24A 3PEBA 2V6CA 2GU5A 4FLKA 1R58A 2Q8KA 2GTXA 4KM3A 4U76A 3FMQA 1QXZA 1XGOA 4FKCA 3IU7A 2BHDA 5CDEA 2Q94A 2OAZA 4MATA 1WL6A 1C22A 4IECA 3IU8A 4ZWPA 2P9AA 3CTZA 1MATA 3OVKA 1O0XA 5E2CA 4PNCA 1QXYA 4RGZ1 1WBQA 3RVAA 1QZYA 1KP0A 4Z7MA 1N51A 3IL0A 4ZWUA 1XGMA 1YW8A 2B3KA 3Q6DA 3OOOA 3S6BA 1XNZA 4S01A 3PKDA 1QXWA 3BIQA 3CB6A 4IKSA 4PV4A 2GG0A 5D6FA 5CE6A 2EVMA 5CDVA 4ZNGA 5FCFA 3O5VA 5CLSA 2Q93A 4FO7A 2NQ6A 3FM3A 5JI6A 3MR1A 3TB5A 4U6EA 3D27A 4U6WA 2Q92A 1WL9A 4S2TP 4U6ZA 2GG2A 3MX6A 4JUQA 4FLJA 2V3XA 2ADUA 3PN9A 2GG5A 4IF7A 4QR8A 1C27A 1C24A 1WKMA 2HOWA 1KQ0A 5JHUA 4RZZA 2B3LA 4U6CA 2GA2A 4IKUA 1WN1A 3BIPA 3CB5A 4ZWOA 4IKTA 2BHBA 5D6EA 4IU6A 4FUKA 4HXXA 2NQ7A 2P99A 2GU4A 2BWTA 2GGCA 2GG9A 1WLRA 4U69A 2GG8A 2ZSGA 4U70A 4IPAA 1JAWA 2V3YA 2BN7A 1BOAA 2Q95A 2BWSA 1A16A 4S2RP 3PKAA 1PV9A 2OKNA 3TAVA 4A6WA 2GU7A 2BWXA 1R5GA 4S00A 1YJ3A 1CHMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PKC A;  2IW2 A;  5FCH A;  2GU6 A;  2Q96 A;  5JFR A;  4IDY A;  4EGE A;  4FLL A;  1BN5 A;  3ROR A;  3FMR A;  3IU9 A;  1W7V A;  4B28 A;  5CDL A;  3MAT A;  1YVM A;  2V3Z A;  1W2M A;  2BH3 A;  1B59 A;  1KQ9 A;  4R60 A;  4U75 A;  2BWU A;  1R5H A;  5CNX A;  3I7M A;  4U73 A;  2MAT A;  3PKB A;  1YW9 A;  2B3H A;  2EA2 A;  4A6V A;  3IG4 A;  4IKR A;  2EVO A;  3L7G A;  2GG7 A;  4OOK A;  2BWV A;  1XGS A;  4U1B A;  1B6A A;  2GGB A;  1C23 A;  1YW7 A;  2BWW A;  2P98 A;  4RZY A;  2DFI A;  4U6J A;  1M35 A;  2BHA A;  5E5B A;  2BB7 A;  3PKE A;  5CIK A;  2BHC A;  4U71 A;  2GZ5 A;  2BWY A;  3BIT A;  2GG3 A;  4FLI A;  3QOC A;  2EA4 A;  2EVC A;  2G6P A;  4FO8 A;  1WY2 A;  1Y1N A;  1C21 A;  1XGN A;  3L24 A;  3PEB A;  2V6C A;  2GU5 A;  4FLK A;  1R58 A;  2Q8K A;  2GTX A;  4KM3 A;  4U76 A;  3FMQ A;  1QXZ A;  1XGO A;  4FKC A;  3IU7 A;  2BHD A;  5CDE A;  2Q94 A;  2OAZ A;  4MAT A;  1WL6 A;  1C22 A;  4IEC A;  3IU8 A;  4ZWP A;  2P9A A;  3CTZ A;  1MAT A;  3OVK A;  1O0X A;  5E2C A;  4PNC A;  1QXY A;  4RGZ 1;  1WBQ A;  3RVA A;  1QZY A;  1KP0 A;  4Z7M A;  1N51 A;  3IL0 A;  4ZWU A;  1XGM A;  1YW8 A;  2B3K A;  3Q6D A;  3OOO A;  3S6B A;  1XNZ A;  4S01 A;  3PKD A;  1QXW A;  3BIQ A;  3CB6 A;  4IKS A;  4PV4 A;  2GG0 A;  5D6F A;  5CE6 A;  2EVM A;  5CDV A;  4ZNG A;  5FCF A;  3O5V A;  5CLS A;  2Q93 A;  4FO7 A;  2NQ6 A;  3FM3 A;  5JI6 A;  3MR1 A;  3TB5 A;  4U6E A;  3D27 A;  4U6W A;  2Q92 A;  1WL9 A;  4S2T P;  4U6Z A;  2GG2 A;  3MX6 A;  4JUQ A;  4FLJ A;  2V3X A;  2ADU A;  3PN9 A;  2GG5 A;  4IF7 A;  4QR8 A;  1C27 A;  1C24 A;  1WKM A;  2HOW A;  1KQ0 A;  5JHU A;  4RZZ A;  2B3L A;  4U6C A;  2GA2 A;  4IKU A;  1WN1 A;  3BIP A;  3CB5 A;  4ZWO A;  4IKT A;  2BHB A;  5D6E A;  4IU6 A;  4FUK A;  4HXX A;  2NQ7 A;  2P99 A;  2GU4 A;  2BWT A;  2GGC A;  2GG9 A;  1WLR A;  4U69 A;  2GG8 A;  2ZSG A;  4U70 A;  4IPA A;  1JAW A;  2V3Y A;  2BN7 A;  1BOA A;  2Q95 A;  2BWS A;  1A16 A;  4S2R P;  3PKA A;  1PV9 A;  2OKN A;  3TAV A;  4A6W A;  2GU7 A;  2BWX A;  1R5G A;  4S00 A;  1YJ3 A;  1CHM A; 
#chains in the Genus database with same CATH topology
 3PKC A;  2IW2 A;  5FCH A;  2GU6 A;  2Q96 A;  5JFR A;  4IDY A;  4EGE A;  4FLL A;  1BN5 A;  3ROR A;  3FMR A;  3IU9 A;  1W7V A;  4B28 A;  5CDL A;  3MAT A;  1YVM A;  2V3Z A;  1W2M A;  2BH3 A;  1B59 A;  1KQ9 A;  4R60 A;  4U75 A;  2BWU A;  1R5H A;  5CNX A;  3I7M A;  4U73 A;  2MAT A;  3PKB A;  1YW9 A;  2B3H A;  2EA2 A;  4A6V A;  3IG4 A;  4IKR A;  2EVO A;  3L7G A;  2GG7 A;  4OOK A;  2BWV A;  1XGS A;  4U1B A;  1B6A A;  2GGB A;  1C23 A;  1YW7 A;  2BWW A;  2P98 A;  4RZY A;  2DFI A;  4U6J A;  1M35 A;  2BHA A;  5E5B A;  2BB7 A;  3PKE A;  5CIK A;  2BHC A;  4U71 A;  2GZ5 A;  2BWY A;  3BIT A;  2GG3 A;  4FLI A;  3QOC A;  2EA4 A;  2EVC A;  2G6P A;  4FO8 A;  1WY2 A;  1Y1N A;  1C21 A;  1XGN A;  3L24 A;  3PEB A;  2V6C A;  2GU5 A;  4FLK A;  1R58 A;  2Q8K A;  2GTX A;  4KM3 A;  4U76 A;  3FMQ A;  1QXZ A;  1XGO A;  4FKC A;  3IU7 A;  2BHD A;  5CDE A;  2Q94 A;  2OAZ A;  4MAT A;  1WL6 A;  1C22 A;  4IEC A;  3IU8 A;  4ZWP A;  2P9A A;  3CTZ A;  1MAT A;  3OVK A;  1O0X A;  5E2C A;  4PNC A;  1QXY A;  4RGZ 1;  1WBQ A;  3RVA A;  1QZY A;  1KP0 A;  4Z7M A;  1N51 A;  3IL0 A;  4ZWU A;  1XGM A;  1YW8 A;  2B3K A;  3Q6D A;  3OOO A;  3S6B A;  1XNZ A;  4S01 A;  3PKD A;  1QXW A;  3BIQ A;  3CB6 A;  4IKS A;  4PV4 A;  2GG0 A;  5D6F A;  5CE6 A;  2EVM A;  5CDV A;  4ZNG A;  5FCF A;  3O5V A;  5CLS A;  2Q93 A;  4FO7 A;  2NQ6 A;  3FM3 A;  5JI6 A;  3MR1 A;  3TB5 A;  4U6E A;  3D27 A;  4U6W A;  2Q92 A;  1WL9 A;  4S2T P;  4U6Z A;  2GG2 A;  3MX6 A;  4JUQ A;  4FLJ A;  2V3X A;  2ADU A;  3PN9 A;  2GG5 A;  4IF7 A;  4QR8 A;  1C27 A;  1C24 A;  1WKM A;  2HOW A;  1KQ0 A;  5JHU A;  4RZZ A;  2B3L A;  4U6C A;  2GA2 A;  4IKU A;  1WN1 A;  3BIP A;  3CB5 A;  4ZWO A;  4IKT A;  2BHB A;  5D6E A;  4IU6 A;  4FUK A;  4HXX A;  2NQ7 A;  2P99 A;  2GU4 A;  2BWT A;  2GGC A;  2GG9 A;  1WLR A;  4U69 A;  2GG8 A;  2ZSG A;  4U70 A;  4IPA A;  1JAW A;  2V3Y A;  2BN7 A;  1BOA A;  2Q95 A;  2BWS A;  1A16 A;  4S2R P;  3PKA A;  1PV9 A;  2OKN A;  3TAV A;  4A6W A;  2GU7 A;  2BWX A;  1R5G A;  4S00 A;  1YJ3 A;  1CHM A; 
#chains in the Genus database with same CATH homology
 3PKC A;  2IW2 A;  5FCH A;  2GU6 A;  2Q96 A;  5JFR A;  4IDY A;  4EGE A;  4FLL A;  1BN5 A;  3ROR A;  3FMR A;  3IU9 A;  1W7V A;  4B28 A;  5CDL A;  3MAT A;  1YVM A;  2V3Z A;  1W2M A;  2BH3 A;  1B59 A;  1KQ9 A;  4R60 A;  4U75 A;  2BWU A;  1R5H A;  5CNX A;  3I7M A;  4U73 A;  2MAT A;  3PKB A;  1YW9 A;  2B3H A;  2EA2 A;  4A6V A;  3IG4 A;  4IKR A;  2EVO A;  3L7G A;  2GG7 A;  4OOK A;  2BWV A;  1XGS A;  4U1B A;  1B6A A;  2GGB A;  1C23 A;  1YW7 A;  2BWW A;  2P98 A;  4RZY A;  2DFI A;  4U6J A;  1M35 A;  2BHA A;  5E5B A;  2BB7 A;  3PKE A;  5CIK A;  2BHC A;  4U71 A;  2GZ5 A;  2BWY A;  3BIT A;  2GG3 A;  4FLI A;  3QOC A;  2EA4 A;  2EVC A;  2G6P A;  4FO8 A;  1WY2 A;  1Y1N A;  1C21 A;  1XGN A;  3L24 A;  3PEB A;  2V6C A;  2GU5 A;  4FLK A;  1R58 A;  2Q8K A;  2GTX A;  4KM3 A;  4U76 A;  3FMQ A;  1QXZ A;  1XGO A;  4FKC A;  3IU7 A;  2BHD A;  5CDE A;  2Q94 A;  2OAZ A;  4MAT A;  1WL6 A;  1C22 A;  4IEC A;  3IU8 A;  4ZWP A;  2P9A A;  3CTZ A;  1MAT A;  3OVK A;  1O0X A;  5E2C A;  4PNC A;  1QXY A;  4RGZ 1;  1WBQ A;  3RVA A;  1QZY A;  1KP0 A;  4Z7M A;  1N51 A;  3IL0 A;  4ZWU A;  1XGM A;  1YW8 A;  2B3K A;  3Q6D A;  3OOO A;  3S6B A;  1XNZ A;  4S01 A;  3PKD A;  1QXW A;  3BIQ A;  3CB6 A;  4IKS A;  4PV4 A;  2GG0 A;  5D6F A;  5CE6 A;  2EVM A;  5CDV A;  4ZNG A;  5FCF A;  3O5V A;  5CLS A;  2Q93 A;  4FO7 A;  2NQ6 A;  3FM3 A;  5JI6 A;  3MR1 A;  3TB5 A;  4U6E A;  3D27 A;  4U6W A;  2Q92 A;  1WL9 A;  4S2T P;  4U6Z A;  2GG2 A;  3MX6 A;  4JUQ A;  4FLJ A;  2V3X A;  2ADU A;  3PN9 A;  2GG5 A;  4IF7 A;  4QR8 A;  1C27 A;  1C24 A;  1WKM A;  2HOW A;  1KQ0 A;  5JHU A;  4RZZ A;  2B3L A;  4U6C A;  2GA2 A;  4IKU A;  1WN1 A;  3BIP A;  3CB5 A;  4ZWO A;  4IKT A;  2BHB A;  5D6E A;  4IU6 A;  4FUK A;  4HXX A;  2NQ7 A;  2P99 A;  2GU4 A;  2BWT A;  2GGC A;  2GG9 A;  1WLR A;  4U69 A;  2GG8 A;  2ZSG A;  4U70 A;  4IPA A;  1JAW A;  2V3Y A;  2BN7 A;  1BOA A;  2Q95 A;  2BWS A;  1A16 A;  4S2R P;  3PKA A;  1PV9 A;  2OKN A;  3TAV A;  4A6W A;  2GU7 A;  2BWX A;  1R5G A;  4S00 A;  1YJ3 A;  1CHM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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