4ZWUA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f, v342l, i215y
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
sequence length
439
structure length
435
Chain Sequence
NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNYVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQLHDVGGFMADEQGAHQEPGHPFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords ORGANOPHOSPHATE ANHYDROLASE/PROLIDASE
total genus 154
structure length 435
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwuA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwuA02
2GG3A 4U71A 4FUKA 3L7GA 2GU4A 1C27A 1YJ3A 2OAZA 4R60A 4U1BA 4PV4A 2V3ZA 3O5VA 2GU6A 1XNZA 5FCFA 1Y1NA 1WL9A 4S01A 2EA4A 2IW2A 1A16A 4Z7MA 5D6EA 1QXZA 2GTXA 4U76A 1XGOA 5JFRA 4OOKA 4S2RP 3PN9A 2BWVA 4IDYA 5JI6A 2P98A 4ZNGA 5CDLA 2V6CA 2GG7A 2Q93A 2GGBA 3CB5A 4U6ZA 5CNXA 1C22A 1BN5A 1N51A 1B59A 1O0XA 2DFIA 4U6CA 2MATA 3I7MA 2BB7A 2NQ6A 3IU9A 2HOWA 2NQ7A 1YW9A 2BN7A 4ZWPA 1QXWA 4FLLA 4RZYA 4S2TP 1XGMA 3D27A 4U69A 4FLJA 1M35A 1WBQA 3IG4A 2P9AA 5E2CA 4U73A 1R5HA 4IKRA 3FMRA 1XGNA 5CIKA 3RVAA 5D6FA 3OOOA 2GG9A 4ZWOA 2GGCA 3MR1A 4IKSA 3FM3A 4U75A 1WKMA 4RGZ1 4KM3A 4IKUA 1C23A 2GU5A 2ZSGA 2Q94A 3TAVA 2B3HA 2BWTA 1WN1A 2BWUA 4FKCA 2GU7A 4U6EA 1YW7A 3CB6A 2GG5A 3FMQA 5CDVA 1YW8A 2Q96A 4FLKA 4S00A 2Q8KA 2GA2A 5CLSA 1B6AA 3MX6A 2EA2A 4IKTA 2BWSA 3IU8A 4QR8A 3RORA 4FO8A 4JUQA 1C24A 1W7VA 2EVOA 2GG0A 4IECA 2ADUA 1XGSA 1KP0A 3PKCA 3TB5A 2OKNA 1QZYA 2B3LA 1MATA 5CE6A 2V3XA 3IU7A 3PKAA 3BIPA 2B3KA 2V3YA 2BHBA 2Q95A 3MATA 3PKBA 2BHCA 2Q92A 3CTZA 1C21A 4FLIA 4EGEA 1WLRA 2BH3A 4U70A 1KQ9A 3BITA 1KQ0A 2P99A 3PKDA 1WL6A 2BHAA 1BOAA 3Q6DA 2EVCA 3S6BA 4FO7A 4A6WA 3BIQA 4RZZA 2G6PA 4IU6A 4PNCA 1QXYA 1JAWA 2BWWA 4A6VA 5CDEA 4ZWUA 5JHUA 3PKEA 2GZ5A 2GG8A 1R5GA 2EVMA 4U6JA 1R58A 3IL0A 4IF7A 4IPAA 3L24A 1WY2A 2BWYA 5E5BA 1W2MA 3QOCA 2BHDA 4U6WA 1YVMA 1CHMA 3OVKA 5FCHA 2GG2A 4HXXA 3PEBA 2BWXA 4B28A 4MATA 1PV9A
chains in the Genus database with same CATH superfamily
2GG3A 4U71A 4FUKA 3L7GA 2GU4A 1C27A 1YJ3A 2OAZA 4R60A 4U1BA 4PV4A 2V3ZA 3O5VA 2GU6A 1XNZA 5FCFA 1Y1NA 1WL9A 4S01A 2EA4A 2IW2A 1A16A 4Z7MA 5D6EA 1QXZA 2GTXA 4U76A 1XGOA 5JFRA 4OOKA 4S2RP 3PN9A 2BWVA 4IDYA 5JI6A 2P98A 4ZNGA 5CDLA 2V6CA 2GG7A 2Q93A 2GGBA 3CB5A 4U6ZA 5CNXA 1C22A 1BN5A 1N51A 1B59A 1O0XA 2DFIA 4U6CA 2MATA 3I7MA 2BB7A 2NQ6A 3IU9A 2HOWA 2NQ7A 1YW9A 2BN7A 4ZWPA 1QXWA 4FLLA 4RZYA 4S2TP 1XGMA 3D27A 4U69A 4FLJA 1M35A 1WBQA 3IG4A 2P9AA 5E2CA 4U73A 1R5HA 4IKRA 3FMRA 1XGNA 5CIKA 3RVAA 5D6FA 3OOOA 2GG9A 4ZWOA 2GGCA 3MR1A 4IKSA 3FM3A 4U75A 1WKMA 4RGZ1 4KM3A 4IKUA 1C23A 2GU5A 2ZSGA 2Q94A 3TAVA 2B3HA 2BWTA 1WN1A 2BWUA 4FKCA 2GU7A 4U6EA 1YW7A 3CB6A 2GG5A 3FMQA 5CDVA 1YW8A 2Q96A 4FLKA 4S00A 2Q8KA 2GA2A 5CLSA 1B6AA 3MX6A 2EA2A 4IKTA 2BWSA 3IU8A 4QR8A 3RORA 4FO8A 4JUQA 1C24A 1W7VA 2EVOA 2GG0A 4IECA 2ADUA 1XGSA 1KP0A 3PKCA 3TB5A 2OKNA 1QZYA 2B3LA 1MATA 5CE6A 2V3XA 3IU7A 3PKAA 3BIPA 2B3KA 2V3YA 2BHBA 2Q95A 3MATA 3PKBA 2BHCA 2Q92A 3CTZA 1C21A 4FLIA 4EGEA 1WLRA 2BH3A 4U70A 1KQ9A 3BITA 1KQ0A 2P99A 3PKDA 1WL6A 2BHAA 1BOAA 3Q6DA 2EVCA 3S6BA 4FO7A 4A6WA 3BIQA 4RZZA 2G6PA 4IU6A 4PNCA 1QXYA 1JAWA 2BWWA 4A6VA 5CDEA 4ZWUA 5JHUA 3PKEA 2GZ5A 2GG8A 1R5GA 2EVMA 4U6JA 1R58A 3IL0A 4IF7A 4IPAA 3L24A 1WY2A 2BWYA 5E5BA 1W2MA 3QOCA 2BHDA 4U6WA 1YVMA 1CHMA 3OVKA 5FCHA 2GG2A 4HXXA 3PEBA 2BWXA 4B28A 4MATA 1PV9A
chains in the Genus database with same CATH topology
2GG3A 4U71A 4FUKA 3L7GA 2GU4A 1C27A 1YJ3A 2OAZA 4R60A 4U1BA 4PV4A 2V3ZA 3O5VA 2GU6A 1XNZA 5FCFA 1Y1NA 1WL9A 4S01A 2EA4A 2IW2A 1A16A 4Z7MA 5D6EA 1QXZA 2GTXA 4U76A 1XGOA 5JFRA 4OOKA 4S2RP 3PN9A 2BWVA 4IDYA 5JI6A 2P98A 4ZNGA 5CDLA 2V6CA 2GG7A 2Q93A 2GGBA 3CB5A 4U6ZA 5CNXA 1C22A 1BN5A 1N51A 1B59A 1O0XA 2DFIA 4U6CA 2MATA 3I7MA 2BB7A 2NQ6A 3IU9A 2HOWA 2NQ7A 1YW9A 2BN7A 4ZWPA 1QXWA 4FLLA 4RZYA 4S2TP 1XGMA 3D27A 4U69A 4FLJA 1M35A 1WBQA 3IG4A 2P9AA 5E2CA 4U73A 1R5HA 4IKRA 3FMRA 1XGNA 5CIKA 3RVAA 5D6FA 3OOOA 2GG9A 4ZWOA 2GGCA 3MR1A 4IKSA 3FM3A 4U75A 1WKMA 4RGZ1 4KM3A 4IKUA 1C23A 2GU5A 2ZSGA 2Q94A 3TAVA 2B3HA 2BWTA 1WN1A 2BWUA 4FKCA 2GU7A 4U6EA 1YW7A 3CB6A 2GG5A 3FMQA 5CDVA 1YW8A 2Q96A 4FLKA 4S00A 2Q8KA 2GA2A 5CLSA 1B6AA 3MX6A 2EA2A 4IKTA 2BWSA 3IU8A 4QR8A 3RORA 4FO8A 4JUQA 1C24A 1W7VA 2EVOA 2GG0A 4IECA 2ADUA 1XGSA 1KP0A 3PKCA 3TB5A 2OKNA 1QZYA 2B3LA 1MATA 5CE6A 2V3XA 3IU7A 3PKAA 3BIPA 2B3KA 2V3YA 2BHBA 2Q95A 3MATA 3PKBA 2BHCA 2Q92A 3CTZA 1C21A 4FLIA 4EGEA 1WLRA 2BH3A 4U70A 1KQ9A 3BITA 1KQ0A 2P99A 3PKDA 1WL6A 2BHAA 1BOAA 3Q6DA 2EVCA 3S6BA 4FO7A 4A6WA 3BIQA 4RZZA 2G6PA 4IU6A 4PNCA 1QXYA 1JAWA 2BWWA 4A6VA 5CDEA 4ZWUA 5JHUA 3PKEA 2GZ5A 2GG8A 1R5GA 2EVMA 4U6JA 1R58A 3IL0A 4IF7A 4IPAA 3L24A 1WY2A 2BWYA 5E5BA 1W2MA 3QOCA 2BHDA 4U6WA 1YVMA 1CHMA 3OVKA 5FCHA 2GG2A 4HXXA 3PEBA 2BWXA 4B28A 4MATA 1PV9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GG3 A;  4U71 A;  4FUK A;  3L7G A;  2GU4 A;  1C27 A;  1YJ3 A;  2OAZ A;  4R60 A;  4U1B A;  4PV4 A;  2V3Z A;  3O5V A;  2GU6 A;  1XNZ A;  5FCF A;  1Y1N A;  1WL9 A;  4S01 A;  2EA4 A;  2IW2 A;  1A16 A;  4Z7M A;  5D6E A;  1QXZ A;  2GTX A;  4U76 A;  1XGO A;  5JFR A;  4OOK A;  4S2R P;  3PN9 A;  2BWV A;  4IDY A;  5JI6 A;  2P98 A;  4ZNG A;  5CDL A;  2V6C A;  2GG7 A;  2Q93 A;  2GGB A;  3CB5 A;  4U6Z A;  5CNX A;  1C22 A;  1BN5 A;  1N51 A;  1B59 A;  1O0X A;  2DFI A;  4U6C A;  2MAT A;  3I7M A;  2BB7 A;  2NQ6 A;  3IU9 A;  2HOW A;  2NQ7 A;  1YW9 A;  2BN7 A;  4ZWP A;  1QXW A;  4FLL A;  4RZY A;  4S2T P;  1XGM A;  3D27 A;  4U69 A;  4FLJ A;  1M35 A;  1WBQ A;  3IG4 A;  2P9A A;  5E2C A;  4U73 A;  1R5H A;  4IKR A;  3FMR A;  1XGN A;  5CIK A;  3RVA A;  5D6F A;  3OOO A;  2GG9 A;  4ZWO A;  2GGC A;  3MR1 A;  4IKS A;  3FM3 A;  4U75 A;  1WKM A;  4RGZ 1;  4KM3 A;  4IKU A;  1C23 A;  2GU5 A;  2ZSG A;  2Q94 A;  3TAV A;  2B3H A;  2BWT A;  1WN1 A;  2BWU A;  4FKC A;  2GU7 A;  4U6E A;  1YW7 A;  3CB6 A;  2GG5 A;  3FMQ A;  5CDV A;  1YW8 A;  2Q96 A;  4FLK A;  4S00 A;  2Q8K A;  2GA2 A;  5CLS A;  1B6A A;  3MX6 A;  2EA2 A;  4IKT A;  2BWS A;  3IU8 A;  4QR8 A;  3ROR A;  4FO8 A;  4JUQ A;  1C24 A;  1W7V A;  2EVO A;  2GG0 A;  4IEC A;  2ADU A;  1XGS A;  1KP0 A;  3PKC A;  3TB5 A;  2OKN A;  1QZY A;  2B3L A;  1MAT A;  5CE6 A;  2V3X A;  3IU7 A;  3PKA A;  3BIP A;  2B3K A;  2V3Y A;  2BHB A;  2Q95 A;  3MAT A;  3PKB A;  2BHC A;  2Q92 A;  3CTZ A;  1C21 A;  4FLI A;  4EGE A;  1WLR A;  2BH3 A;  4U70 A;  1KQ9 A;  3BIT A;  1KQ0 A;  2P99 A;  3PKD A;  1WL6 A;  2BHA A;  1BOA A;  3Q6D A;  2EVC A;  3S6B A;  4FO7 A;  4A6W A;  3BIQ A;  4RZZ A;  2G6P A;  4IU6 A;  4PNC A;  1QXY A;  1JAW A;  2BWW A;  4A6V A;  5CDE A;  4ZWU A;  5JHU A;  3PKE A;  2GZ5 A;  2GG8 A;  1R5G A;  2EVM A;  4U6J A;  1R58 A;  3IL0 A;  4IF7 A;  4IPA A;  3L24 A;  1WY2 A;  2BWY A;  5E5B A;  1W2M A;  3QOC A;  2BHD A;  4U6W A;  1YVM A;  1CHM A;  3OVK A;  5FCH A;  2GG2 A;  4HXX A;  3PEB A;  2BWX A;  4B28 A;  4MAT A;  1PV9 A; 
#chains in the Genus database with same CATH topology
 2GG3 A;  4U71 A;  4FUK A;  3L7G A;  2GU4 A;  1C27 A;  1YJ3 A;  2OAZ A;  4R60 A;  4U1B A;  4PV4 A;  2V3Z A;  3O5V A;  2GU6 A;  1XNZ A;  5FCF A;  1Y1N A;  1WL9 A;  4S01 A;  2EA4 A;  2IW2 A;  1A16 A;  4Z7M A;  5D6E A;  1QXZ A;  2GTX A;  4U76 A;  1XGO A;  5JFR A;  4OOK A;  4S2R P;  3PN9 A;  2BWV A;  4IDY A;  5JI6 A;  2P98 A;  4ZNG A;  5CDL A;  2V6C A;  2GG7 A;  2Q93 A;  2GGB A;  3CB5 A;  4U6Z A;  5CNX A;  1C22 A;  1BN5 A;  1N51 A;  1B59 A;  1O0X A;  2DFI A;  4U6C A;  2MAT A;  3I7M A;  2BB7 A;  2NQ6 A;  3IU9 A;  2HOW A;  2NQ7 A;  1YW9 A;  2BN7 A;  4ZWP A;  1QXW A;  4FLL A;  4RZY A;  4S2T P;  1XGM A;  3D27 A;  4U69 A;  4FLJ A;  1M35 A;  1WBQ A;  3IG4 A;  2P9A A;  5E2C A;  4U73 A;  1R5H A;  4IKR A;  3FMR A;  1XGN A;  5CIK A;  3RVA A;  5D6F A;  3OOO A;  2GG9 A;  4ZWO A;  2GGC A;  3MR1 A;  4IKS A;  3FM3 A;  4U75 A;  1WKM A;  4RGZ 1;  4KM3 A;  4IKU A;  1C23 A;  2GU5 A;  2ZSG A;  2Q94 A;  3TAV A;  2B3H A;  2BWT A;  1WN1 A;  2BWU A;  4FKC A;  2GU7 A;  4U6E A;  1YW7 A;  3CB6 A;  2GG5 A;  3FMQ A;  5CDV A;  1YW8 A;  2Q96 A;  4FLK A;  4S00 A;  2Q8K A;  2GA2 A;  5CLS A;  1B6A A;  3MX6 A;  2EA2 A;  4IKT A;  2BWS A;  3IU8 A;  4QR8 A;  3ROR A;  4FO8 A;  4JUQ A;  1C24 A;  1W7V A;  2EVO A;  2GG0 A;  4IEC A;  2ADU A;  1XGS A;  1KP0 A;  3PKC A;  3TB5 A;  2OKN A;  1QZY A;  2B3L A;  1MAT A;  5CE6 A;  2V3X A;  3IU7 A;  3PKA A;  3BIP A;  2B3K A;  2V3Y A;  2BHB A;  2Q95 A;  3MAT A;  3PKB A;  2BHC A;  2Q92 A;  3CTZ A;  1C21 A;  4FLI A;  4EGE A;  1WLR A;  2BH3 A;  4U70 A;  1KQ9 A;  3BIT A;  1KQ0 A;  2P99 A;  3PKD A;  1WL6 A;  2BHA A;  1BOA A;  3Q6D A;  2EVC A;  3S6B A;  4FO7 A;  4A6W A;  3BIQ A;  4RZZ A;  2G6P A;  4IU6 A;  4PNC A;  1QXY A;  1JAW A;  2BWW A;  4A6V A;  5CDE A;  4ZWU A;  5JHU A;  3PKE A;  2GZ5 A;  2GG8 A;  1R5G A;  2EVM A;  4U6J A;  1R58 A;  3IL0 A;  4IF7 A;  4IPA A;  3L24 A;  1WY2 A;  2BWY A;  5E5B A;  1W2M A;  3QOC A;  2BHD A;  4U6W A;  1YVM A;  1CHM A;  3OVK A;  5FCH A;  2GG2 A;  4HXX A;  3PEB A;  2BWX A;  4B28 A;  4MAT A;  1PV9 A; 
#chains in the Genus database with same CATH homology
 2GG3 A;  4U71 A;  4FUK A;  3L7G A;  2GU4 A;  1C27 A;  1YJ3 A;  2OAZ A;  4R60 A;  4U1B A;  4PV4 A;  2V3Z A;  3O5V A;  2GU6 A;  1XNZ A;  5FCF A;  1Y1N A;  1WL9 A;  4S01 A;  2EA4 A;  2IW2 A;  1A16 A;  4Z7M A;  5D6E A;  1QXZ A;  2GTX A;  4U76 A;  1XGO A;  5JFR A;  4OOK A;  4S2R P;  3PN9 A;  2BWV A;  4IDY A;  5JI6 A;  2P98 A;  4ZNG A;  5CDL A;  2V6C A;  2GG7 A;  2Q93 A;  2GGB A;  3CB5 A;  4U6Z A;  5CNX A;  1C22 A;  1BN5 A;  1N51 A;  1B59 A;  1O0X A;  2DFI A;  4U6C A;  2MAT A;  3I7M A;  2BB7 A;  2NQ6 A;  3IU9 A;  2HOW A;  2NQ7 A;  1YW9 A;  2BN7 A;  4ZWP A;  1QXW A;  4FLL A;  4RZY A;  4S2T P;  1XGM A;  3D27 A;  4U69 A;  4FLJ A;  1M35 A;  1WBQ A;  3IG4 A;  2P9A A;  5E2C A;  4U73 A;  1R5H A;  4IKR A;  3FMR A;  1XGN A;  5CIK A;  3RVA A;  5D6F A;  3OOO A;  2GG9 A;  4ZWO A;  2GGC A;  3MR1 A;  4IKS A;  3FM3 A;  4U75 A;  1WKM A;  4RGZ 1;  4KM3 A;  4IKU A;  1C23 A;  2GU5 A;  2ZSG A;  2Q94 A;  3TAV A;  2B3H A;  2BWT A;  1WN1 A;  2BWU A;  4FKC A;  2GU7 A;  4U6E A;  1YW7 A;  3CB6 A;  2GG5 A;  3FMQ A;  5CDV A;  1YW8 A;  2Q96 A;  4FLK A;  4S00 A;  2Q8K A;  2GA2 A;  5CLS A;  1B6A A;  3MX6 A;  2EA2 A;  4IKT A;  2BWS A;  3IU8 A;  4QR8 A;  3ROR A;  4FO8 A;  4JUQ A;  1C24 A;  1W7V A;  2EVO A;  2GG0 A;  4IEC A;  2ADU A;  1XGS A;  1KP0 A;  3PKC A;  3TB5 A;  2OKN A;  1QZY A;  2B3L A;  1MAT A;  5CE6 A;  2V3X A;  3IU7 A;  3PKA A;  3BIP A;  2B3K A;  2V3Y A;  2BHB A;  2Q95 A;  3MAT A;  3PKB A;  2BHC A;  2Q92 A;  3CTZ A;  1C21 A;  4FLI A;  4EGE A;  1WLR A;  2BH3 A;  4U70 A;  1KQ9 A;  3BIT A;  1KQ0 A;  2P99 A;  3PKD A;  1WL6 A;  2BHA A;  1BOA A;  3Q6D A;  2EVC A;  3S6B A;  4FO7 A;  4A6W A;  3BIQ A;  4RZZ A;  2G6P A;  4IU6 A;  4PNC A;  1QXY A;  1JAW A;  2BWW A;  4A6V A;  5CDE A;  4ZWU A;  5JHU A;  3PKE A;  2GZ5 A;  2GG8 A;  1R5G A;  2EVM A;  4U6J A;  1R58 A;  3IL0 A;  4IF7 A;  4IPA A;  3L24 A;  1WY2 A;  2BWY A;  5E5B A;  1W2M A;  3QOC A;  2BHD A;  4U6W A;  1YVM A;  1CHM A;  3OVK A;  5FCH A;  2GG2 A;  4HXX A;  3PEB A;  2BWX A;  4B28 A;  4MAT A;  1PV9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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