4ZWUA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f, v342l, i215y
Total Genus 154
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
sequence length
439
structure length
435
Chain Sequence
b'NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNYVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQLHDVGGFMADEQGAHQEPGHPFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ORGANOPHOSPHATE ANHYDROLASE/PROLIDASE
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
total genus 154
structure length 435
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwuA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwuA02
4U71A 2BWVA 1MATA 5E2CA 4U1BA 1XGMA 1CHMA 5CE6A 1C22A 2EVOA 1R5HA 2NQ7A 1QZYA 2BB7A 3FMQA 4FLLA 4U6WA 2V3XA 2BWTA 3IL0A 1XGSA 2BN7A 4HXXA 4U69A 2Q96A 2B3LA 1JAWA 4OOKA 2DFIA 1WBQA 4R60A 5JI6A 5CDEA 1C27A 3FMRA 4PNCA 2P9AA 2GG7A 1R5GA 3L24A 1QXWA 1BN5A 2GG9A 4ZWUA 1B59A 4PV4A 4U75A 2B3KA 3MATA 1WN1A 4Z7MA 4QR8A 4FUKA 2Q93A 3PEBA 1YW7A 4B28A 1W7VA 2Q92A 5JFRA 2IW2A 3QOCA 1KQ9A 3OVKA 1Y1NA 4ZNGA 4FLKA 3PN9A 1C21A 2GGBA 3MX6A 4RZYA 2OAZA 4U6ZA 1XGOA 1KP0A 2Q95A 2BWWA 1QXYA 5D6FA 2GU4A 3O5VA 5FCHA 4IECA 3TAVA 3MR1A 2BWSA 2EA4A 3BITA 4ZWPA 2G6PA 2BHBA 2P99A 2BWXA 2GGCA 5CDLA 2ZSGA 3IU9A 1QXZA 1YW9A 2V6CA 3OOOA 3FM3A 5CLSA 3TB5A 1C23A 1M35A 5FCFA 3PKDA 1XGNA 5CDVA 4FLIA 4IKUA 3PKEA 3PKAA 2MATA 4MATA 1C24A 3RVAA 2GG8A 4RGZ1 1WKMA 4JUQA 2BHAA 1YW8A 2BWYA 4EGEA 1XNZA 2GZ5A 2GG0A 4S2RP 4A6WA 3L7GA 5E5BA 2Q94A 5D6EA 2V3ZA 4IU6A 4IPAA 2EA2A 4IF7A 2BWUA 2HOWA 2NQ6A 1WY2A 3PKCA 2GTXA 4U6EA 4U70A 1W2MA 4ZWOA 2BHDA 4U6CA 4U73A 2P98A 3RORA 1WL6A 5JHUA 4IKSA 1BOAA 3D27A 4IKRA 2ADUA 4FLJA 3CTZA 3BIQA 2V3YA 4FKCA 3PKBA 2BH3A 2BHCA 1YJ3A 2GU6A 1WLRA 3CB6A 1N51A 1O0XA 4A6VA 1A16A 3BIPA 1R58A 2GG5A 2GU5A 3IG4A 4S2TP 4FO8A 2GG2A 5CNXA 5CIKA 4IDYA 3I7MA 3IU8A 4U6JA 3S6BA 3Q6DA 1YVMA 4S01A 2Q8KA 2EVCA 4IKTA 4FO7A 2EVMA 3CB5A 2GA2A 2B3HA 4KM3A 3IU7A 2GU7A 1KQ0A 2OKNA 4U76A 4S00A 1B6AA 1PV9A 1WL9A 4RZZA 2GG3A
chains in the Genus database with same CATH superfamily
4U71A 2BWVA 1MATA 5E2CA 4U1BA 1XGMA 1CHMA 5CE6A 1C22A 2EVOA 1R5HA 2NQ7A 1QZYA 2BB7A 3FMQA 4FLLA 4U6WA 2V3XA 2BWTA 3IL0A 1XGSA 2BN7A 4HXXA 4U69A 2Q96A 2B3LA 1JAWA 4OOKA 2DFIA 1WBQA 4R60A 5JI6A 5CDEA 1C27A 3FMRA 4PNCA 2P9AA 2GG7A 1R5GA 3L24A 1QXWA 1BN5A 2GG9A 4ZWUA 1B59A 4PV4A 4U75A 2B3KA 3MATA 1WN1A 4Z7MA 4QR8A 4FUKA 2Q93A 3PEBA 1YW7A 4B28A 1W7VA 2Q92A 5JFRA 2IW2A 3QOCA 1KQ9A 3OVKA 1Y1NA 4ZNGA 4FLKA 3PN9A 1C21A 2GGBA 3MX6A 4RZYA 2OAZA 4U6ZA 1XGOA 1KP0A 2Q95A 2BWWA 1QXYA 5D6FA 2GU4A 3O5VA 5FCHA 4IECA 3TAVA 3MR1A 2BWSA 2EA4A 3BITA 4ZWPA 2G6PA 2BHBA 2P99A 2BWXA 2GGCA 5CDLA 2ZSGA 3IU9A 1QXZA 1YW9A 2V6CA 3OOOA 3FM3A 5CLSA 3TB5A 1C23A 1M35A 5FCFA 3PKDA 1XGNA 5CDVA 4FLIA 4IKUA 3PKEA 3PKAA 2MATA 4MATA 1C24A 3RVAA 2GG8A 4RGZ1 1WKMA 4JUQA 2BHAA 1YW8A 2BWYA 4EGEA 1XNZA 2GZ5A 2GG0A 4S2RP 4A6WA 3L7GA 5E5BA 2Q94A 5D6EA 2V3ZA 4IU6A 4IPAA 2EA2A 4IF7A 2BWUA 2HOWA 2NQ6A 1WY2A 3PKCA 2GTXA 4U6EA 4U70A 1W2MA 4ZWOA 2BHDA 4U6CA 4U73A 2P98A 3RORA 1WL6A 5JHUA 4IKSA 1BOAA 3D27A 4IKRA 2ADUA 4FLJA 3CTZA 3BIQA 2V3YA 4FKCA 3PKBA 2BH3A 2BHCA 1YJ3A 2GU6A 1WLRA 3CB6A 1N51A 1O0XA 4A6VA 1A16A 3BIPA 1R58A 2GG5A 2GU5A 3IG4A 4S2TP 4FO8A 2GG2A 5CNXA 5CIKA 4IDYA 3I7MA 3IU8A 4U6JA 3S6BA 3Q6DA 1YVMA 4S01A 2Q8KA 2EVCA 4IKTA 4FO7A 2EVMA 3CB5A 2GA2A 2B3HA 4KM3A 3IU7A 2GU7A 1KQ0A 2OKNA 4U76A 4S00A 1B6AA 1PV9A 1WL9A 4RZZA 2GG3A
chains in the Genus database with same CATH topology
4U71A 2BWVA 1MATA 5E2CA 4U1BA 1XGMA 1CHMA 5CE6A 1C22A 2EVOA 1R5HA 2NQ7A 1QZYA 2BB7A 3FMQA 4FLLA 4U6WA 2V3XA 2BWTA 3IL0A 1XGSA 2BN7A 4HXXA 4U69A 2Q96A 2B3LA 1JAWA 4OOKA 2DFIA 1WBQA 4R60A 5JI6A 5CDEA 1C27A 3FMRA 4PNCA 2P9AA 2GG7A 1R5GA 3L24A 1QXWA 1BN5A 2GG9A 4ZWUA 1B59A 4PV4A 4U75A 2B3KA 3MATA 1WN1A 4Z7MA 4QR8A 4FUKA 2Q93A 3PEBA 1YW7A 4B28A 1W7VA 2Q92A 5JFRA 2IW2A 3QOCA 1KQ9A 3OVKA 1Y1NA 4ZNGA 4FLKA 3PN9A 1C21A 2GGBA 3MX6A 4RZYA 2OAZA 4U6ZA 1XGOA 1KP0A 2Q95A 2BWWA 1QXYA 5D6FA 2GU4A 3O5VA 5FCHA 4IECA 3TAVA 3MR1A 2BWSA 2EA4A 3BITA 4ZWPA 2G6PA 2BHBA 2P99A 2BWXA 2GGCA 5CDLA 2ZSGA 3IU9A 1QXZA 1YW9A 2V6CA 3OOOA 3FM3A 5CLSA 3TB5A 1C23A 1M35A 5FCFA 3PKDA 1XGNA 5CDVA 4FLIA 4IKUA 3PKEA 3PKAA 2MATA 4MATA 1C24A 3RVAA 2GG8A 4RGZ1 1WKMA 4JUQA 2BHAA 1YW8A 2BWYA 4EGEA 1XNZA 2GZ5A 2GG0A 4S2RP 4A6WA 3L7GA 5E5BA 2Q94A 5D6EA 2V3ZA 4IU6A 4IPAA 2EA2A 4IF7A 2BWUA 2HOWA 2NQ6A 1WY2A 3PKCA 2GTXA 4U6EA 4U70A 1W2MA 4ZWOA 2BHDA 4U6CA 4U73A 2P98A 3RORA 1WL6A 5JHUA 4IKSA 1BOAA 3D27A 4IKRA 2ADUA 4FLJA 3CTZA 3BIQA 2V3YA 4FKCA 3PKBA 2BH3A 2BHCA 1YJ3A 2GU6A 1WLRA 3CB6A 1N51A 1O0XA 4A6VA 1A16A 3BIPA 1R58A 2GG5A 2GU5A 3IG4A 4S2TP 4FO8A 2GG2A 5CNXA 5CIKA 4IDYA 3I7MA 3IU8A 4U6JA 3S6BA 3Q6DA 1YVMA 4S01A 2Q8KA 2EVCA 4IKTA 4FO7A 2EVMA 3CB5A 2GA2A 2B3HA 4KM3A 3IU7A 2GU7A 1KQ0A 2OKNA 4U76A 4S00A 1B6AA 1PV9A 1WL9A 4RZZA 2GG3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U71 A;  2BWV A;  1MAT A;  5E2C A;  4U1B A;  1XGM A;  1CHM A;  5CE6 A;  1C22 A;  2EVO A;  1R5H A;  2NQ7 A;  1QZY A;  2BB7 A;  3FMQ A;  4FLL A;  4U6W A;  2V3X A;  2BWT A;  3IL0 A;  1XGS A;  2BN7 A;  4HXX A;  4U69 A;  2Q96 A;  2B3L A;  1JAW A;  4OOK A;  2DFI A;  1WBQ A;  4R60 A;  5JI6 A;  5CDE A;  1C27 A;  3FMR A;  4PNC A;  2P9A A;  2GG7 A;  1R5G A;  3L24 A;  1QXW A;  1BN5 A;  2GG9 A;  4ZWU A;  1B59 A;  4PV4 A;  4U75 A;  2B3K A;  3MAT A;  1WN1 A;  4Z7M A;  4QR8 A;  4FUK A;  2Q93 A;  3PEB A;  1YW7 A;  4B28 A;  1W7V A;  2Q92 A;  5JFR A;  2IW2 A;  3QOC A;  1KQ9 A;  3OVK A;  1Y1N A;  4ZNG A;  4FLK A;  3PN9 A;  1C21 A;  2GGB A;  3MX6 A;  4RZY A;  2OAZ A;  4U6Z A;  1XGO A;  1KP0 A;  2Q95 A;  2BWW A;  1QXY A;  5D6F A;  2GU4 A;  3O5V A;  5FCH A;  4IEC A;  3TAV A;  3MR1 A;  2BWS A;  2EA4 A;  3BIT A;  4ZWP A;  2G6P A;  2BHB A;  2P99 A;  2BWX A;  2GGC A;  5CDL A;  2ZSG A;  3IU9 A;  1QXZ A;  1YW9 A;  2V6C A;  3OOO A;  3FM3 A;  5CLS A;  3TB5 A;  1C23 A;  1M35 A;  5FCF A;  3PKD A;  1XGN A;  5CDV A;  4FLI A;  4IKU A;  3PKE A;  3PKA A;  2MAT A;  4MAT A;  1C24 A;  3RVA A;  2GG8 A;  4RGZ 1;  1WKM A;  4JUQ A;  2BHA A;  1YW8 A;  2BWY A;  4EGE A;  1XNZ A;  2GZ5 A;  2GG0 A;  4S2R P;  4A6W A;  3L7G A;  5E5B A;  2Q94 A;  5D6E A;  2V3Z A;  4IU6 A;  4IPA A;  2EA2 A;  4IF7 A;  2BWU A;  2HOW A;  2NQ6 A;  1WY2 A;  3PKC A;  2GTX A;  4U6E A;  4U70 A;  1W2M A;  4ZWO A;  2BHD A;  4U6C A;  4U73 A;  2P98 A;  3ROR A;  1WL6 A;  5JHU A;  4IKS A;  1BOA A;  3D27 A;  4IKR A;  2ADU A;  4FLJ A;  3CTZ A;  3BIQ A;  2V3Y A;  4FKC A;  3PKB A;  2BH3 A;  2BHC A;  1YJ3 A;  2GU6 A;  1WLR A;  3CB6 A;  1N51 A;  1O0X A;  4A6V A;  1A16 A;  3BIP A;  1R58 A;  2GG5 A;  2GU5 A;  3IG4 A;  4S2T P;  4FO8 A;  2GG2 A;  5CNX A;  5CIK A;  4IDY A;  3I7M A;  3IU8 A;  4U6J A;  3S6B A;  3Q6D A;  1YVM A;  4S01 A;  2Q8K A;  2EVC A;  4IKT A;  4FO7 A;  2EVM A;  3CB5 A;  2GA2 A;  2B3H A;  4KM3 A;  3IU7 A;  2GU7 A;  1KQ0 A;  2OKN A;  4U76 A;  4S00 A;  1B6A A;  1PV9 A;  1WL9 A;  4RZZ A;  2GG3 A; 
#chains in the Genus database with same CATH topology
 4U71 A;  2BWV A;  1MAT A;  5E2C A;  4U1B A;  1XGM A;  1CHM A;  5CE6 A;  1C22 A;  2EVO A;  1R5H A;  2NQ7 A;  1QZY A;  2BB7 A;  3FMQ A;  4FLL A;  4U6W A;  2V3X A;  2BWT A;  3IL0 A;  1XGS A;  2BN7 A;  4HXX A;  4U69 A;  2Q96 A;  2B3L A;  1JAW A;  4OOK A;  2DFI A;  1WBQ A;  4R60 A;  5JI6 A;  5CDE A;  1C27 A;  3FMR A;  4PNC A;  2P9A A;  2GG7 A;  1R5G A;  3L24 A;  1QXW A;  1BN5 A;  2GG9 A;  4ZWU A;  1B59 A;  4PV4 A;  4U75 A;  2B3K A;  3MAT A;  1WN1 A;  4Z7M A;  4QR8 A;  4FUK A;  2Q93 A;  3PEB A;  1YW7 A;  4B28 A;  1W7V A;  2Q92 A;  5JFR A;  2IW2 A;  3QOC A;  1KQ9 A;  3OVK A;  1Y1N A;  4ZNG A;  4FLK A;  3PN9 A;  1C21 A;  2GGB A;  3MX6 A;  4RZY A;  2OAZ A;  4U6Z A;  1XGO A;  1KP0 A;  2Q95 A;  2BWW A;  1QXY A;  5D6F A;  2GU4 A;  3O5V A;  5FCH A;  4IEC A;  3TAV A;  3MR1 A;  2BWS A;  2EA4 A;  3BIT A;  4ZWP A;  2G6P A;  2BHB A;  2P99 A;  2BWX A;  2GGC A;  5CDL A;  2ZSG A;  3IU9 A;  1QXZ A;  1YW9 A;  2V6C A;  3OOO A;  3FM3 A;  5CLS A;  3TB5 A;  1C23 A;  1M35 A;  5FCF A;  3PKD A;  1XGN A;  5CDV A;  4FLI A;  4IKU A;  3PKE A;  3PKA A;  2MAT A;  4MAT A;  1C24 A;  3RVA A;  2GG8 A;  4RGZ 1;  1WKM A;  4JUQ A;  2BHA A;  1YW8 A;  2BWY A;  4EGE A;  1XNZ A;  2GZ5 A;  2GG0 A;  4S2R P;  4A6W A;  3L7G A;  5E5B A;  2Q94 A;  5D6E A;  2V3Z A;  4IU6 A;  4IPA A;  2EA2 A;  4IF7 A;  2BWU A;  2HOW A;  2NQ6 A;  1WY2 A;  3PKC A;  2GTX A;  4U6E A;  4U70 A;  1W2M A;  4ZWO A;  2BHD A;  4U6C A;  4U73 A;  2P98 A;  3ROR A;  1WL6 A;  5JHU A;  4IKS A;  1BOA A;  3D27 A;  4IKR A;  2ADU A;  4FLJ A;  3CTZ A;  3BIQ A;  2V3Y A;  4FKC A;  3PKB A;  2BH3 A;  2BHC A;  1YJ3 A;  2GU6 A;  1WLR A;  3CB6 A;  1N51 A;  1O0X A;  4A6V A;  1A16 A;  3BIP A;  1R58 A;  2GG5 A;  2GU5 A;  3IG4 A;  4S2T P;  4FO8 A;  2GG2 A;  5CNX A;  5CIK A;  4IDY A;  3I7M A;  3IU8 A;  4U6J A;  3S6B A;  3Q6D A;  1YVM A;  4S01 A;  2Q8K A;  2EVC A;  4IKT A;  4FO7 A;  2EVM A;  3CB5 A;  2GA2 A;  2B3H A;  4KM3 A;  3IU7 A;  2GU7 A;  1KQ0 A;  2OKN A;  4U76 A;  4S00 A;  1B6A A;  1PV9 A;  1WL9 A;  4RZZ A;  2GG3 A; 
#chains in the Genus database with same CATH homology
 4U71 A;  2BWV A;  1MAT A;  5E2C A;  4U1B A;  1XGM A;  1CHM A;  5CE6 A;  1C22 A;  2EVO A;  1R5H A;  2NQ7 A;  1QZY A;  2BB7 A;  3FMQ A;  4FLL A;  4U6W A;  2V3X A;  2BWT A;  3IL0 A;  1XGS A;  2BN7 A;  4HXX A;  4U69 A;  2Q96 A;  2B3L A;  1JAW A;  4OOK A;  2DFI A;  1WBQ A;  4R60 A;  5JI6 A;  5CDE A;  1C27 A;  3FMR A;  4PNC A;  2P9A A;  2GG7 A;  1R5G A;  3L24 A;  1QXW A;  1BN5 A;  2GG9 A;  4ZWU A;  1B59 A;  4PV4 A;  4U75 A;  2B3K A;  3MAT A;  1WN1 A;  4Z7M A;  4QR8 A;  4FUK A;  2Q93 A;  3PEB A;  1YW7 A;  4B28 A;  1W7V A;  2Q92 A;  5JFR A;  2IW2 A;  3QOC A;  1KQ9 A;  3OVK A;  1Y1N A;  4ZNG A;  4FLK A;  3PN9 A;  1C21 A;  2GGB A;  3MX6 A;  4RZY A;  2OAZ A;  4U6Z A;  1XGO A;  1KP0 A;  2Q95 A;  2BWW A;  1QXY A;  5D6F A;  2GU4 A;  3O5V A;  5FCH A;  4IEC A;  3TAV A;  3MR1 A;  2BWS A;  2EA4 A;  3BIT A;  4ZWP A;  2G6P A;  2BHB A;  2P99 A;  2BWX A;  2GGC A;  5CDL A;  2ZSG A;  3IU9 A;  1QXZ A;  1YW9 A;  2V6C A;  3OOO A;  3FM3 A;  5CLS A;  3TB5 A;  1C23 A;  1M35 A;  5FCF A;  3PKD A;  1XGN A;  5CDV A;  4FLI A;  4IKU A;  3PKE A;  3PKA A;  2MAT A;  4MAT A;  1C24 A;  3RVA A;  2GG8 A;  4RGZ 1;  1WKM A;  4JUQ A;  2BHA A;  1YW8 A;  2BWY A;  4EGE A;  1XNZ A;  2GZ5 A;  2GG0 A;  4S2R P;  4A6W A;  3L7G A;  5E5B A;  2Q94 A;  5D6E A;  2V3Z A;  4IU6 A;  4IPA A;  2EA2 A;  4IF7 A;  2BWU A;  2HOW A;  2NQ6 A;  1WY2 A;  3PKC A;  2GTX A;  4U6E A;  4U70 A;  1W2M A;  4ZWO A;  2BHD A;  4U6C A;  4U73 A;  2P98 A;  3ROR A;  1WL6 A;  5JHU A;  4IKS A;  1BOA A;  3D27 A;  4IKR A;  2ADU A;  4FLJ A;  3CTZ A;  3BIQ A;  2V3Y A;  4FKC A;  3PKB A;  2BH3 A;  2BHC A;  1YJ3 A;  2GU6 A;  1WLR A;  3CB6 A;  1N51 A;  1O0X A;  4A6V A;  1A16 A;  3BIP A;  1R58 A;  2GG5 A;  2GU5 A;  3IG4 A;  4S2T P;  4FO8 A;  2GG2 A;  5CNX A;  5CIK A;  4IDY A;  3I7M A;  3IU8 A;  4U6J A;  3S6B A;  3Q6D A;  1YVM A;  4S01 A;  2Q8K A;  2EVC A;  4IKT A;  4FO7 A;  2EVM A;  3CB5 A;  2GA2 A;  2B3H A;  4KM3 A;  3IU7 A;  2GU7 A;  1KQ0 A;  2OKN A;  4U76 A;  4S00 A;  1B6A A;  1PV9 A;  1WL9 A;  4RZZ A;  2GG3 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...