4ZWUA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f, v342l, i215y
Total Genus 154
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
sequence length
439
structure length
435
Chain Sequence
NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNYVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQLHDVGGFMADEQGAHQEPGHPFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords ORGANOPHOSPHATE ANHYDROLASE/PROLIDASE
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
total genus 154
structure length 435
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwuA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwuA02
5CLSA 1WL6A 5JI6A 2BWXA 4PV4A 4ZWUA 5CIKA 2Q95A 4FLKA 4B28A 5CDVA 4IKUA 1QXYA 1C22A 4OOKA 1C23A 4U71A 2V3XA 4ZWOA 5D6FA 1KQ0A 2V3YA 4A6VA 4S2TP 3O5VA 2Q8KA 3I7MA 2BWWA 2GG2A 2V6CA 4U73A 3BIQA 2EA4A 2EA2A 3FMQA 2BWSA 1C24A 5E2CA 2EVCA 2EVOA 4U69A 3OOOA 4U1BA 3MR1A 3Q6DA 4FUKA 3BITA 1WY2A 1YW7A 3L7GA 4FLIA 1A16A 1YJ3A 5CDLA 4U6WA 1W2MA 4QR8A 1JAWA 3IU9A 3CB6A 1KP0A 2BWUA 1B59A 3BIPA 1YW9A 2GU5A 2P99A 1BN5A 4IKSA 3TAVA 1WKMA 1R58A 1W7VA 1R5GA 2BB7A 3FM3A 3PKBA 3TB5A 1C21A 5D6EA 4U6ZA 1QZYA 4JUQA 2BHDA 4RZZA 2GG3A 2BHCA 1XGOA 2GU6A 1WLRA 3RVAA 2P9AA 5CNXA 2BWTA 2IW2A 5CE6A 2GG8A 1XGNA 2B3KA 2GZ5A 2NQ6A 1WBQA 3PN9A 4ZNGA 2BHBA 1XNZA 1YVMA 3CB5A 2GTXA 4Z7MA 4S01A 4FKCA 1QXWA 2NQ7A 3QOCA 5E5BA 3CTZA 3FMRA 4KM3A 2GA2A 2Q92A 4PNCA 4IKRA 4EGEA 4R60A 3IL0A 2OAZA 4FLJA 3PEBA 2ADUA 2EVMA 4IKTA 1MATA 1O0XA 2DFIA 2Q93A 1WN1A 1C27A 2B3HA 1B6AA 4IU6A 2GU4A 2GU7A 3IU8A 3S6BA 3PKEA 2Q96A 4ZWPA 3L24A 4FLLA 2GG7A 4FO7A 4IPAA 3IU7A 3PKAA 4U75A 2BH3A 1Y1NA 4RGZ1 1QXZA 3PKCA 5FCFA 2V3ZA 1PV9A 4U70A 5JFRA 2OKNA 4FO8A 2Q94A 3MX6A 2ZSGA 3MATA 2BN7A 1CHMA 1N51A 5CDEA 3PKDA 1M35A 2GGCA 4A6WA 2G6PA 2HOWA 4RZYA 1KQ9A 2B3LA 2BWYA 1XGSA 2MATA 4HXXA 1WL9A 4IF7A 2BHAA 2GGBA 4IECA 4IDYA 5FCHA 2GG0A 4U6EA 3OVKA 4MATA 4S2RP 2P98A 2GG9A 2GG5A 3RORA 1XGMA 4U6JA 4U76A 3IG4A 4U6CA 1YW8A 5JHUA 2BWVA 3D27A 4S00A 1BOAA 1R5HA
chains in the Genus database with same CATH superfamily
5CLSA 1WL6A 5JI6A 2BWXA 4PV4A 4ZWUA 5CIKA 2Q95A 4FLKA 4B28A 5CDVA 4IKUA 1QXYA 1C22A 4OOKA 1C23A 4U71A 2V3XA 4ZWOA 5D6FA 1KQ0A 2V3YA 4A6VA 4S2TP 3O5VA 2Q8KA 3I7MA 2BWWA 2GG2A 2V6CA 4U73A 3BIQA 2EA4A 2EA2A 3FMQA 2BWSA 1C24A 5E2CA 2EVCA 2EVOA 4U69A 3OOOA 4U1BA 3MR1A 3Q6DA 4FUKA 3BITA 1WY2A 1YW7A 3L7GA 4FLIA 1A16A 1YJ3A 5CDLA 4U6WA 1W2MA 4QR8A 1JAWA 3IU9A 3CB6A 1KP0A 2BWUA 1B59A 3BIPA 1YW9A 2GU5A 2P99A 1BN5A 4IKSA 3TAVA 1WKMA 1R58A 1W7VA 1R5GA 2BB7A 3FM3A 3PKBA 3TB5A 1C21A 5D6EA 4U6ZA 1QZYA 4JUQA 2BHDA 4RZZA 2GG3A 2BHCA 1XGOA 2GU6A 1WLRA 3RVAA 2P9AA 5CNXA 2BWTA 2IW2A 5CE6A 2GG8A 1XGNA 2B3KA 2GZ5A 2NQ6A 1WBQA 3PN9A 4ZNGA 2BHBA 1XNZA 1YVMA 3CB5A 2GTXA 4Z7MA 4S01A 4FKCA 1QXWA 2NQ7A 3QOCA 5E5BA 3CTZA 3FMRA 4KM3A 2GA2A 2Q92A 4PNCA 4IKRA 4EGEA 4R60A 3IL0A 2OAZA 4FLJA 3PEBA 2ADUA 2EVMA 4IKTA 1MATA 1O0XA 2DFIA 2Q93A 1WN1A 1C27A 2B3HA 1B6AA 4IU6A 2GU4A 2GU7A 3IU8A 3S6BA 3PKEA 2Q96A 4ZWPA 3L24A 4FLLA 2GG7A 4FO7A 4IPAA 3IU7A 3PKAA 4U75A 2BH3A 1Y1NA 4RGZ1 1QXZA 3PKCA 5FCFA 2V3ZA 1PV9A 4U70A 5JFRA 2OKNA 4FO8A 2Q94A 3MX6A 2ZSGA 3MATA 2BN7A 1CHMA 1N51A 5CDEA 3PKDA 1M35A 2GGCA 4A6WA 2G6PA 2HOWA 4RZYA 1KQ9A 2B3LA 2BWYA 1XGSA 2MATA 4HXXA 1WL9A 4IF7A 2BHAA 2GGBA 4IECA 4IDYA 5FCHA 2GG0A 4U6EA 3OVKA 4MATA 4S2RP 2P98A 2GG9A 2GG5A 3RORA 1XGMA 4U6JA 4U76A 3IG4A 4U6CA 1YW8A 5JHUA 2BWVA 3D27A 4S00A 1BOAA 1R5HA
chains in the Genus database with same CATH topology
5CLSA 1WL6A 5JI6A 2BWXA 4PV4A 4ZWUA 5CIKA 2Q95A 4FLKA 4B28A 5CDVA 4IKUA 1QXYA 1C22A 4OOKA 1C23A 4U71A 2V3XA 4ZWOA 5D6FA 1KQ0A 2V3YA 4A6VA 4S2TP 3O5VA 2Q8KA 3I7MA 2BWWA 2GG2A 2V6CA 4U73A 3BIQA 2EA4A 2EA2A 3FMQA 2BWSA 1C24A 5E2CA 2EVCA 2EVOA 4U69A 3OOOA 4U1BA 3MR1A 3Q6DA 4FUKA 3BITA 1WY2A 1YW7A 3L7GA 4FLIA 1A16A 1YJ3A 5CDLA 4U6WA 1W2MA 4QR8A 1JAWA 3IU9A 3CB6A 1KP0A 2BWUA 1B59A 3BIPA 1YW9A 2GU5A 2P99A 1BN5A 4IKSA 3TAVA 1WKMA 1R58A 1W7VA 1R5GA 2BB7A 3FM3A 3PKBA 3TB5A 1C21A 5D6EA 4U6ZA 1QZYA 4JUQA 2BHDA 4RZZA 2GG3A 2BHCA 1XGOA 2GU6A 1WLRA 3RVAA 2P9AA 5CNXA 2BWTA 2IW2A 5CE6A 2GG8A 1XGNA 2B3KA 2GZ5A 2NQ6A 1WBQA 3PN9A 4ZNGA 2BHBA 1XNZA 1YVMA 3CB5A 2GTXA 4Z7MA 4S01A 4FKCA 1QXWA 2NQ7A 3QOCA 5E5BA 3CTZA 3FMRA 4KM3A 2GA2A 2Q92A 4PNCA 4IKRA 4EGEA 4R60A 3IL0A 2OAZA 4FLJA 3PEBA 2ADUA 2EVMA 4IKTA 1MATA 1O0XA 2DFIA 2Q93A 1WN1A 1C27A 2B3HA 1B6AA 4IU6A 2GU4A 2GU7A 3IU8A 3S6BA 3PKEA 2Q96A 4ZWPA 3L24A 4FLLA 2GG7A 4FO7A 4IPAA 3IU7A 3PKAA 4U75A 2BH3A 1Y1NA 4RGZ1 1QXZA 3PKCA 5FCFA 2V3ZA 1PV9A 4U70A 5JFRA 2OKNA 4FO8A 2Q94A 3MX6A 2ZSGA 3MATA 2BN7A 1CHMA 1N51A 5CDEA 3PKDA 1M35A 2GGCA 4A6WA 2G6PA 2HOWA 4RZYA 1KQ9A 2B3LA 2BWYA 1XGSA 2MATA 4HXXA 1WL9A 4IF7A 2BHAA 2GGBA 4IECA 4IDYA 5FCHA 2GG0A 4U6EA 3OVKA 4MATA 4S2RP 2P98A 2GG9A 2GG5A 3RORA 1XGMA 4U6JA 4U76A 3IG4A 4U6CA 1YW8A 5JHUA 2BWVA 3D27A 4S00A 1BOAA 1R5HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CLS A;  1WL6 A;  5JI6 A;  2BWX A;  4PV4 A;  4ZWU A;  5CIK A;  2Q95 A;  4FLK A;  4B28 A;  5CDV A;  4IKU A;  1QXY A;  1C22 A;  4OOK A;  1C23 A;  4U71 A;  2V3X A;  4ZWO A;  5D6F A;  1KQ0 A;  2V3Y A;  4A6V A;  4S2T P;  3O5V A;  2Q8K A;  3I7M A;  2BWW A;  2GG2 A;  2V6C A;  4U73 A;  3BIQ A;  2EA4 A;  2EA2 A;  3FMQ A;  2BWS A;  1C24 A;  5E2C A;  2EVC A;  2EVO A;  4U69 A;  3OOO A;  4U1B A;  3MR1 A;  3Q6D A;  4FUK A;  3BIT A;  1WY2 A;  1YW7 A;  3L7G A;  4FLI A;  1A16 A;  1YJ3 A;  5CDL A;  4U6W A;  1W2M A;  4QR8 A;  1JAW A;  3IU9 A;  3CB6 A;  1KP0 A;  2BWU A;  1B59 A;  3BIP A;  1YW9 A;  2GU5 A;  2P99 A;  1BN5 A;  4IKS A;  3TAV A;  1WKM A;  1R58 A;  1W7V A;  1R5G A;  2BB7 A;  3FM3 A;  3PKB A;  3TB5 A;  1C21 A;  5D6E A;  4U6Z A;  1QZY A;  4JUQ A;  2BHD A;  4RZZ A;  2GG3 A;  2BHC A;  1XGO A;  2GU6 A;  1WLR A;  3RVA A;  2P9A A;  5CNX A;  2BWT A;  2IW2 A;  5CE6 A;  2GG8 A;  1XGN A;  2B3K A;  2GZ5 A;  2NQ6 A;  1WBQ A;  3PN9 A;  4ZNG A;  2BHB A;  1XNZ A;  1YVM A;  3CB5 A;  2GTX A;  4Z7M A;  4S01 A;  4FKC A;  1QXW A;  2NQ7 A;  3QOC A;  5E5B A;  3CTZ A;  3FMR A;  4KM3 A;  2GA2 A;  2Q92 A;  4PNC A;  4IKR A;  4EGE A;  4R60 A;  3IL0 A;  2OAZ A;  4FLJ A;  3PEB A;  2ADU A;  2EVM A;  4IKT A;  1MAT A;  1O0X A;  2DFI A;  2Q93 A;  1WN1 A;  1C27 A;  2B3H A;  1B6A A;  4IU6 A;  2GU4 A;  2GU7 A;  3IU8 A;  3S6B A;  3PKE A;  2Q96 A;  4ZWP A;  3L24 A;  4FLL A;  2GG7 A;  4FO7 A;  4IPA A;  3IU7 A;  3PKA A;  4U75 A;  2BH3 A;  1Y1N A;  4RGZ 1;  1QXZ A;  3PKC A;  5FCF A;  2V3Z A;  1PV9 A;  4U70 A;  5JFR A;  2OKN A;  4FO8 A;  2Q94 A;  3MX6 A;  2ZSG A;  3MAT A;  2BN7 A;  1CHM A;  1N51 A;  5CDE A;  3PKD A;  1M35 A;  2GGC A;  4A6W A;  2G6P A;  2HOW A;  4RZY A;  1KQ9 A;  2B3L A;  2BWY A;  1XGS A;  2MAT A;  4HXX A;  1WL9 A;  4IF7 A;  2BHA A;  2GGB A;  4IEC A;  4IDY A;  5FCH A;  2GG0 A;  4U6E A;  3OVK A;  4MAT A;  4S2R P;  2P98 A;  2GG9 A;  2GG5 A;  3ROR A;  1XGM A;  4U6J A;  4U76 A;  3IG4 A;  4U6C A;  1YW8 A;  5JHU A;  2BWV A;  3D27 A;  4S00 A;  1BOA A;  1R5H A; 
#chains in the Genus database with same CATH topology
 5CLS A;  1WL6 A;  5JI6 A;  2BWX A;  4PV4 A;  4ZWU A;  5CIK A;  2Q95 A;  4FLK A;  4B28 A;  5CDV A;  4IKU A;  1QXY A;  1C22 A;  4OOK A;  1C23 A;  4U71 A;  2V3X A;  4ZWO A;  5D6F A;  1KQ0 A;  2V3Y A;  4A6V A;  4S2T P;  3O5V A;  2Q8K A;  3I7M A;  2BWW A;  2GG2 A;  2V6C A;  4U73 A;  3BIQ A;  2EA4 A;  2EA2 A;  3FMQ A;  2BWS A;  1C24 A;  5E2C A;  2EVC A;  2EVO A;  4U69 A;  3OOO A;  4U1B A;  3MR1 A;  3Q6D A;  4FUK A;  3BIT A;  1WY2 A;  1YW7 A;  3L7G A;  4FLI A;  1A16 A;  1YJ3 A;  5CDL A;  4U6W A;  1W2M A;  4QR8 A;  1JAW A;  3IU9 A;  3CB6 A;  1KP0 A;  2BWU A;  1B59 A;  3BIP A;  1YW9 A;  2GU5 A;  2P99 A;  1BN5 A;  4IKS A;  3TAV A;  1WKM A;  1R58 A;  1W7V A;  1R5G A;  2BB7 A;  3FM3 A;  3PKB A;  3TB5 A;  1C21 A;  5D6E A;  4U6Z A;  1QZY A;  4JUQ A;  2BHD A;  4RZZ A;  2GG3 A;  2BHC A;  1XGO A;  2GU6 A;  1WLR A;  3RVA A;  2P9A A;  5CNX A;  2BWT A;  2IW2 A;  5CE6 A;  2GG8 A;  1XGN A;  2B3K A;  2GZ5 A;  2NQ6 A;  1WBQ A;  3PN9 A;  4ZNG A;  2BHB A;  1XNZ A;  1YVM A;  3CB5 A;  2GTX A;  4Z7M A;  4S01 A;  4FKC A;  1QXW A;  2NQ7 A;  3QOC A;  5E5B A;  3CTZ A;  3FMR A;  4KM3 A;  2GA2 A;  2Q92 A;  4PNC A;  4IKR A;  4EGE A;  4R60 A;  3IL0 A;  2OAZ A;  4FLJ A;  3PEB A;  2ADU A;  2EVM A;  4IKT A;  1MAT A;  1O0X A;  2DFI A;  2Q93 A;  1WN1 A;  1C27 A;  2B3H A;  1B6A A;  4IU6 A;  2GU4 A;  2GU7 A;  3IU8 A;  3S6B A;  3PKE A;  2Q96 A;  4ZWP A;  3L24 A;  4FLL A;  2GG7 A;  4FO7 A;  4IPA A;  3IU7 A;  3PKA A;  4U75 A;  2BH3 A;  1Y1N A;  4RGZ 1;  1QXZ A;  3PKC A;  5FCF A;  2V3Z A;  1PV9 A;  4U70 A;  5JFR A;  2OKN A;  4FO8 A;  2Q94 A;  3MX6 A;  2ZSG A;  3MAT A;  2BN7 A;  1CHM A;  1N51 A;  5CDE A;  3PKD A;  1M35 A;  2GGC A;  4A6W A;  2G6P A;  2HOW A;  4RZY A;  1KQ9 A;  2B3L A;  2BWY A;  1XGS A;  2MAT A;  4HXX A;  1WL9 A;  4IF7 A;  2BHA A;  2GGB A;  4IEC A;  4IDY A;  5FCH A;  2GG0 A;  4U6E A;  3OVK A;  4MAT A;  4S2R P;  2P98 A;  2GG9 A;  2GG5 A;  3ROR A;  1XGM A;  4U6J A;  4U76 A;  3IG4 A;  4U6C A;  1YW8 A;  5JHU A;  2BWV A;  3D27 A;  4S00 A;  1BOA A;  1R5H A; 
#chains in the Genus database with same CATH homology
 5CLS A;  1WL6 A;  5JI6 A;  2BWX A;  4PV4 A;  4ZWU A;  5CIK A;  2Q95 A;  4FLK A;  4B28 A;  5CDV A;  4IKU A;  1QXY A;  1C22 A;  4OOK A;  1C23 A;  4U71 A;  2V3X A;  4ZWO A;  5D6F A;  1KQ0 A;  2V3Y A;  4A6V A;  4S2T P;  3O5V A;  2Q8K A;  3I7M A;  2BWW A;  2GG2 A;  2V6C A;  4U73 A;  3BIQ A;  2EA4 A;  2EA2 A;  3FMQ A;  2BWS A;  1C24 A;  5E2C A;  2EVC A;  2EVO A;  4U69 A;  3OOO A;  4U1B A;  3MR1 A;  3Q6D A;  4FUK A;  3BIT A;  1WY2 A;  1YW7 A;  3L7G A;  4FLI A;  1A16 A;  1YJ3 A;  5CDL A;  4U6W A;  1W2M A;  4QR8 A;  1JAW A;  3IU9 A;  3CB6 A;  1KP0 A;  2BWU A;  1B59 A;  3BIP A;  1YW9 A;  2GU5 A;  2P99 A;  1BN5 A;  4IKS A;  3TAV A;  1WKM A;  1R58 A;  1W7V A;  1R5G A;  2BB7 A;  3FM3 A;  3PKB A;  3TB5 A;  1C21 A;  5D6E A;  4U6Z A;  1QZY A;  4JUQ A;  2BHD A;  4RZZ A;  2GG3 A;  2BHC A;  1XGO A;  2GU6 A;  1WLR A;  3RVA A;  2P9A A;  5CNX A;  2BWT A;  2IW2 A;  5CE6 A;  2GG8 A;  1XGN A;  2B3K A;  2GZ5 A;  2NQ6 A;  1WBQ A;  3PN9 A;  4ZNG A;  2BHB A;  1XNZ A;  1YVM A;  3CB5 A;  2GTX A;  4Z7M A;  4S01 A;  4FKC A;  1QXW A;  2NQ7 A;  3QOC A;  5E5B A;  3CTZ A;  3FMR A;  4KM3 A;  2GA2 A;  2Q92 A;  4PNC A;  4IKR A;  4EGE A;  4R60 A;  3IL0 A;  2OAZ A;  4FLJ A;  3PEB A;  2ADU A;  2EVM A;  4IKT A;  1MAT A;  1O0X A;  2DFI A;  2Q93 A;  1WN1 A;  1C27 A;  2B3H A;  1B6A A;  4IU6 A;  2GU4 A;  2GU7 A;  3IU8 A;  3S6B A;  3PKE A;  2Q96 A;  4ZWP A;  3L24 A;  4FLL A;  2GG7 A;  4FO7 A;  4IPA A;  3IU7 A;  3PKA A;  4U75 A;  2BH3 A;  1Y1N A;  4RGZ 1;  1QXZ A;  3PKC A;  5FCF A;  2V3Z A;  1PV9 A;  4U70 A;  5JFR A;  2OKN A;  4FO8 A;  2Q94 A;  3MX6 A;  2ZSG A;  3MAT A;  2BN7 A;  1CHM A;  1N51 A;  5CDE A;  3PKD A;  1M35 A;  2GGC A;  4A6W A;  2G6P A;  2HOW A;  4RZY A;  1KQ9 A;  2B3L A;  2BWY A;  1XGS A;  2MAT A;  4HXX A;  1WL9 A;  4IF7 A;  2BHA A;  2GGB A;  4IEC A;  4IDY A;  5FCH A;  2GG0 A;  4U6E A;  3OVK A;  4MAT A;  4S2R P;  2P98 A;  2GG9 A;  2GG5 A;  3ROR A;  1XGM A;  4U6J A;  4U76 A;  3IG4 A;  4U6C A;  1YW8 A;  5JHU A;  2BWV A;  3D27 A;  4S00 A;  1BOA A;  1R5H A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...