4ZWUA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f, v342l, i215y
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
sequence length
439
structure length
435
Chain Sequence
NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNYVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQLHDVGGFMADEQGAHQEPGHPFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
molecule keywords ORGANOPHOSPHATE ANHYDROLASE/PROLIDASE
total genus 154
structure length 435
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwuA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwuA02
1A16A 4IKRA 3PKBA 1W2MA 1WKMA 5CDLA 4PNCA 4U6ZA 4OOKA 2BWVA 2OKNA 2BWXA 3MATA 3MR1A 4RGZ1 1QXWA 1YW7A 1C24A 1KQ9A 1QXYA 3IG4A 1R5HA 2GU7A 4RZYA 5JI6A 2DFIA 4FO8A 4IECA 1XGOA 2GGBA 2GG7A 2GTXA 5JFRA 1YW8A 5CDEA 4IPAA 2ZSGA 2BWWA 2EA2A 4PV4A 2BHCA 1BN5A 3FMRA 1B6AA 1M35A 3BIQA 2GZ5A 5D6EA 5FCFA 4FLKA 1B59A 2Q96A 3BITA 1XNZA 2P99A 3L24A 3MX6A 3PKCA 4U6WA 4U75A 3RORA 2BHAA 2B3LA 1WY2A 2V3ZA 3O5VA 1YW9A 2B3HA 3PKEA 4U71A 3PKDA 3QOCA 2G6PA 1QXZA 4HXXA 4U1BA 1WN1A 3PN9A 3IU9A 2Q8KA 2P9AA 2GG0A 3L7GA 2GG9A 4ZWUA 2Q94A 1WL6A 5E5BA 2EA4A 1WBQA 2V3YA 4IU6A 2B3KA 2GG5A 4FKCA 4A6VA 4IDYA 1W7VA 4S2TP 4U6EA 1QZYA 4FO7A 3TB5A 1C27A 1N51A 4EGEA 4QR8A 3FM3A 5JHUA 5CIKA 2GG3A 5CDVA 4U6JA 2V6CA 1Y1NA 1MATA 5E2CA 3S6BA 1CHMA 5D6FA 2GGCA 2BHBA 2HOWA 4S2RP 4KM3A 2ADUA 1JAWA 4R60A 1C23A 3PKAA 1R58A 2GG8A 2BHDA 4A6WA 1KP0A 4FUKA 2BB7A 2Q93A 1YVMA 3TAVA 4IKTA 3CB5A 2BN7A 3OOOA 1C21A 1C22A 2IW2A 2GU6A 3OVKA 3I7MA 4S00A 4RZZA 3PEBA 1KQ0A 2Q92A 4Z7MA 5CE6A 4JUQA 2V3XA 2EVCA 4IKSA 2EVOA 4FLLA 3BIPA 4U70A 4U73A 3Q6DA 1WL9A 5CNXA 3IL0A 3RVAA 4IF7A 4ZWPA 1WLRA 3CTZA 5FCHA 3FMQA 2NQ6A 2Q95A 3IU7A 1PV9A 4ZNGA 2P98A 2BH3A 3CB6A 2GG2A 2BWUA 2BWSA 4ZWOA 1XGMA 2GA2A 5CLSA 1R5GA 4U76A 1XGSA 4IKUA 2MATA 4B28A 1O0XA 3D27A 4FLJA 2BWTA 3IU8A 1YJ3A 4U6CA 4FLIA 2NQ7A 2GU5A 1XGNA 2EVMA 4S01A 1BOAA 2GU4A 2BWYA 4MATA 4U69A 2OAZA
chains in the Genus database with same CATH superfamily
1A16A 4IKRA 3PKBA 1W2MA 1WKMA 5CDLA 4PNCA 4U6ZA 4OOKA 2BWVA 2OKNA 2BWXA 3MATA 3MR1A 4RGZ1 1QXWA 1YW7A 1C24A 1KQ9A 1QXYA 3IG4A 1R5HA 2GU7A 4RZYA 5JI6A 2DFIA 4FO8A 4IECA 1XGOA 2GGBA 2GG7A 2GTXA 5JFRA 1YW8A 5CDEA 4IPAA 2ZSGA 2BWWA 2EA2A 4PV4A 2BHCA 1BN5A 3FMRA 1B6AA 1M35A 3BIQA 2GZ5A 5D6EA 5FCFA 4FLKA 1B59A 2Q96A 3BITA 1XNZA 2P99A 3L24A 3MX6A 3PKCA 4U6WA 4U75A 3RORA 2BHAA 2B3LA 1WY2A 2V3ZA 3O5VA 1YW9A 2B3HA 3PKEA 4U71A 3PKDA 3QOCA 2G6PA 1QXZA 4HXXA 4U1BA 1WN1A 3PN9A 3IU9A 2Q8KA 2P9AA 2GG0A 3L7GA 2GG9A 4ZWUA 2Q94A 1WL6A 5E5BA 2EA4A 1WBQA 2V3YA 4IU6A 2B3KA 2GG5A 4FKCA 4A6VA 4IDYA 1W7VA 4S2TP 4U6EA 1QZYA 4FO7A 3TB5A 1C27A 1N51A 4EGEA 4QR8A 3FM3A 5JHUA 5CIKA 2GG3A 5CDVA 4U6JA 2V6CA 1Y1NA 1MATA 5E2CA 3S6BA 1CHMA 5D6FA 2GGCA 2BHBA 2HOWA 4S2RP 4KM3A 2ADUA 1JAWA 4R60A 1C23A 3PKAA 1R58A 2GG8A 2BHDA 4A6WA 1KP0A 4FUKA 2BB7A 2Q93A 1YVMA 3TAVA 4IKTA 3CB5A 2BN7A 3OOOA 1C21A 1C22A 2IW2A 2GU6A 3OVKA 3I7MA 4S00A 4RZZA 3PEBA 1KQ0A 2Q92A 4Z7MA 5CE6A 4JUQA 2V3XA 2EVCA 4IKSA 2EVOA 4FLLA 3BIPA 4U70A 4U73A 3Q6DA 1WL9A 5CNXA 3IL0A 3RVAA 4IF7A 4ZWPA 1WLRA 3CTZA 5FCHA 3FMQA 2NQ6A 2Q95A 3IU7A 1PV9A 4ZNGA 2P98A 2BH3A 3CB6A 2GG2A 2BWUA 2BWSA 4ZWOA 1XGMA 2GA2A 5CLSA 1R5GA 4U76A 1XGSA 4IKUA 2MATA 4B28A 1O0XA 3D27A 4FLJA 2BWTA 3IU8A 1YJ3A 4U6CA 4FLIA 2NQ7A 2GU5A 1XGNA 2EVMA 4S01A 1BOAA 2GU4A 2BWYA 4MATA 4U69A 2OAZA
chains in the Genus database with same CATH topology
1A16A 4IKRA 3PKBA 1W2MA 1WKMA 5CDLA 4PNCA 4U6ZA 4OOKA 2BWVA 2OKNA 2BWXA 3MATA 3MR1A 4RGZ1 1QXWA 1YW7A 1C24A 1KQ9A 1QXYA 3IG4A 1R5HA 2GU7A 4RZYA 5JI6A 2DFIA 4FO8A 4IECA 1XGOA 2GGBA 2GG7A 2GTXA 5JFRA 1YW8A 5CDEA 4IPAA 2ZSGA 2BWWA 2EA2A 4PV4A 2BHCA 1BN5A 3FMRA 1B6AA 1M35A 3BIQA 2GZ5A 5D6EA 5FCFA 4FLKA 1B59A 2Q96A 3BITA 1XNZA 2P99A 3L24A 3MX6A 3PKCA 4U6WA 4U75A 3RORA 2BHAA 2B3LA 1WY2A 2V3ZA 3O5VA 1YW9A 2B3HA 3PKEA 4U71A 3PKDA 3QOCA 2G6PA 1QXZA 4HXXA 4U1BA 1WN1A 3PN9A 3IU9A 2Q8KA 2P9AA 2GG0A 3L7GA 2GG9A 4ZWUA 2Q94A 1WL6A 5E5BA 2EA4A 1WBQA 2V3YA 4IU6A 2B3KA 2GG5A 4FKCA 4A6VA 4IDYA 1W7VA 4S2TP 4U6EA 1QZYA 4FO7A 3TB5A 1C27A 1N51A 4EGEA 4QR8A 3FM3A 5JHUA 5CIKA 2GG3A 5CDVA 4U6JA 2V6CA 1Y1NA 1MATA 5E2CA 3S6BA 1CHMA 5D6FA 2GGCA 2BHBA 2HOWA 4S2RP 4KM3A 2ADUA 1JAWA 4R60A 1C23A 3PKAA 1R58A 2GG8A 2BHDA 4A6WA 1KP0A 4FUKA 2BB7A 2Q93A 1YVMA 3TAVA 4IKTA 3CB5A 2BN7A 3OOOA 1C21A 1C22A 2IW2A 2GU6A 3OVKA 3I7MA 4S00A 4RZZA 3PEBA 1KQ0A 2Q92A 4Z7MA 5CE6A 4JUQA 2V3XA 2EVCA 4IKSA 2EVOA 4FLLA 3BIPA 4U70A 4U73A 3Q6DA 1WL9A 5CNXA 3IL0A 3RVAA 4IF7A 4ZWPA 1WLRA 3CTZA 5FCHA 3FMQA 2NQ6A 2Q95A 3IU7A 1PV9A 4ZNGA 2P98A 2BH3A 3CB6A 2GG2A 2BWUA 2BWSA 4ZWOA 1XGMA 2GA2A 5CLSA 1R5GA 4U76A 1XGSA 4IKUA 2MATA 4B28A 1O0XA 3D27A 4FLJA 2BWTA 3IU8A 1YJ3A 4U6CA 4FLIA 2NQ7A 2GU5A 1XGNA 2EVMA 4S01A 1BOAA 2GU4A 2BWYA 4MATA 4U69A 2OAZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A16 A;  4IKR A;  3PKB A;  1W2M A;  1WKM A;  5CDL A;  4PNC A;  4U6Z A;  4OOK A;  2BWV A;  2OKN A;  2BWX A;  3MAT A;  3MR1 A;  4RGZ 1;  1QXW A;  1YW7 A;  1C24 A;  1KQ9 A;  1QXY A;  3IG4 A;  1R5H A;  2GU7 A;  4RZY A;  5JI6 A;  2DFI A;  4FO8 A;  4IEC A;  1XGO A;  2GGB A;  2GG7 A;  2GTX A;  5JFR A;  1YW8 A;  5CDE A;  4IPA A;  2ZSG A;  2BWW A;  2EA2 A;  4PV4 A;  2BHC A;  1BN5 A;  3FMR A;  1B6A A;  1M35 A;  3BIQ A;  2GZ5 A;  5D6E A;  5FCF A;  4FLK A;  1B59 A;  2Q96 A;  3BIT A;  1XNZ A;  2P99 A;  3L24 A;  3MX6 A;  3PKC A;  4U6W A;  4U75 A;  3ROR A;  2BHA A;  2B3L A;  1WY2 A;  2V3Z A;  3O5V A;  1YW9 A;  2B3H A;  3PKE A;  4U71 A;  3PKD A;  3QOC A;  2G6P A;  1QXZ A;  4HXX A;  4U1B A;  1WN1 A;  3PN9 A;  3IU9 A;  2Q8K A;  2P9A A;  2GG0 A;  3L7G A;  2GG9 A;  4ZWU A;  2Q94 A;  1WL6 A;  5E5B A;  2EA4 A;  1WBQ A;  2V3Y A;  4IU6 A;  2B3K A;  2GG5 A;  4FKC A;  4A6V A;  4IDY A;  1W7V A;  4S2T P;  4U6E A;  1QZY A;  4FO7 A;  3TB5 A;  1C27 A;  1N51 A;  4EGE A;  4QR8 A;  3FM3 A;  5JHU A;  5CIK A;  2GG3 A;  5CDV A;  4U6J A;  2V6C A;  1Y1N A;  1MAT A;  5E2C A;  3S6B A;  1CHM A;  5D6F A;  2GGC A;  2BHB A;  2HOW A;  4S2R P;  4KM3 A;  2ADU A;  1JAW A;  4R60 A;  1C23 A;  3PKA A;  1R58 A;  2GG8 A;  2BHD A;  4A6W A;  1KP0 A;  4FUK A;  2BB7 A;  2Q93 A;  1YVM A;  3TAV A;  4IKT A;  3CB5 A;  2BN7 A;  3OOO A;  1C21 A;  1C22 A;  2IW2 A;  2GU6 A;  3OVK A;  3I7M A;  4S00 A;  4RZZ A;  3PEB A;  1KQ0 A;  2Q92 A;  4Z7M A;  5CE6 A;  4JUQ A;  2V3X A;  2EVC A;  4IKS A;  2EVO A;  4FLL A;  3BIP A;  4U70 A;  4U73 A;  3Q6D A;  1WL9 A;  5CNX A;  3IL0 A;  3RVA A;  4IF7 A;  4ZWP A;  1WLR A;  3CTZ A;  5FCH A;  3FMQ A;  2NQ6 A;  2Q95 A;  3IU7 A;  1PV9 A;  4ZNG A;  2P98 A;  2BH3 A;  3CB6 A;  2GG2 A;  2BWU A;  2BWS A;  4ZWO A;  1XGM A;  2GA2 A;  5CLS A;  1R5G A;  4U76 A;  1XGS A;  4IKU A;  2MAT A;  4B28 A;  1O0X A;  3D27 A;  4FLJ A;  2BWT A;  3IU8 A;  1YJ3 A;  4U6C A;  4FLI A;  2NQ7 A;  2GU5 A;  1XGN A;  2EVM A;  4S01 A;  1BOA A;  2GU4 A;  2BWY A;  4MAT A;  4U69 A;  2OAZ A; 
#chains in the Genus database with same CATH topology
 1A16 A;  4IKR A;  3PKB A;  1W2M A;  1WKM A;  5CDL A;  4PNC A;  4U6Z A;  4OOK A;  2BWV A;  2OKN A;  2BWX A;  3MAT A;  3MR1 A;  4RGZ 1;  1QXW A;  1YW7 A;  1C24 A;  1KQ9 A;  1QXY A;  3IG4 A;  1R5H A;  2GU7 A;  4RZY A;  5JI6 A;  2DFI A;  4FO8 A;  4IEC A;  1XGO A;  2GGB A;  2GG7 A;  2GTX A;  5JFR A;  1YW8 A;  5CDE A;  4IPA A;  2ZSG A;  2BWW A;  2EA2 A;  4PV4 A;  2BHC A;  1BN5 A;  3FMR A;  1B6A A;  1M35 A;  3BIQ A;  2GZ5 A;  5D6E A;  5FCF A;  4FLK A;  1B59 A;  2Q96 A;  3BIT A;  1XNZ A;  2P99 A;  3L24 A;  3MX6 A;  3PKC A;  4U6W A;  4U75 A;  3ROR A;  2BHA A;  2B3L A;  1WY2 A;  2V3Z A;  3O5V A;  1YW9 A;  2B3H A;  3PKE A;  4U71 A;  3PKD A;  3QOC A;  2G6P A;  1QXZ A;  4HXX A;  4U1B A;  1WN1 A;  3PN9 A;  3IU9 A;  2Q8K A;  2P9A A;  2GG0 A;  3L7G A;  2GG9 A;  4ZWU A;  2Q94 A;  1WL6 A;  5E5B A;  2EA4 A;  1WBQ A;  2V3Y A;  4IU6 A;  2B3K A;  2GG5 A;  4FKC A;  4A6V A;  4IDY A;  1W7V A;  4S2T P;  4U6E A;  1QZY A;  4FO7 A;  3TB5 A;  1C27 A;  1N51 A;  4EGE A;  4QR8 A;  3FM3 A;  5JHU A;  5CIK A;  2GG3 A;  5CDV A;  4U6J A;  2V6C A;  1Y1N A;  1MAT A;  5E2C A;  3S6B A;  1CHM A;  5D6F A;  2GGC A;  2BHB A;  2HOW A;  4S2R P;  4KM3 A;  2ADU A;  1JAW A;  4R60 A;  1C23 A;  3PKA A;  1R58 A;  2GG8 A;  2BHD A;  4A6W A;  1KP0 A;  4FUK A;  2BB7 A;  2Q93 A;  1YVM A;  3TAV A;  4IKT A;  3CB5 A;  2BN7 A;  3OOO A;  1C21 A;  1C22 A;  2IW2 A;  2GU6 A;  3OVK A;  3I7M A;  4S00 A;  4RZZ A;  3PEB A;  1KQ0 A;  2Q92 A;  4Z7M A;  5CE6 A;  4JUQ A;  2V3X A;  2EVC A;  4IKS A;  2EVO A;  4FLL A;  3BIP A;  4U70 A;  4U73 A;  3Q6D A;  1WL9 A;  5CNX A;  3IL0 A;  3RVA A;  4IF7 A;  4ZWP A;  1WLR A;  3CTZ A;  5FCH A;  3FMQ A;  2NQ6 A;  2Q95 A;  3IU7 A;  1PV9 A;  4ZNG A;  2P98 A;  2BH3 A;  3CB6 A;  2GG2 A;  2BWU A;  2BWS A;  4ZWO A;  1XGM A;  2GA2 A;  5CLS A;  1R5G A;  4U76 A;  1XGS A;  4IKU A;  2MAT A;  4B28 A;  1O0X A;  3D27 A;  4FLJ A;  2BWT A;  3IU8 A;  1YJ3 A;  4U6C A;  4FLI A;  2NQ7 A;  2GU5 A;  1XGN A;  2EVM A;  4S01 A;  1BOA A;  2GU4 A;  2BWY A;  4MAT A;  4U69 A;  2OAZ A; 
#chains in the Genus database with same CATH homology
 1A16 A;  4IKR A;  3PKB A;  1W2M A;  1WKM A;  5CDL A;  4PNC A;  4U6Z A;  4OOK A;  2BWV A;  2OKN A;  2BWX A;  3MAT A;  3MR1 A;  4RGZ 1;  1QXW A;  1YW7 A;  1C24 A;  1KQ9 A;  1QXY A;  3IG4 A;  1R5H A;  2GU7 A;  4RZY A;  5JI6 A;  2DFI A;  4FO8 A;  4IEC A;  1XGO A;  2GGB A;  2GG7 A;  2GTX A;  5JFR A;  1YW8 A;  5CDE A;  4IPA A;  2ZSG A;  2BWW A;  2EA2 A;  4PV4 A;  2BHC A;  1BN5 A;  3FMR A;  1B6A A;  1M35 A;  3BIQ A;  2GZ5 A;  5D6E A;  5FCF A;  4FLK A;  1B59 A;  2Q96 A;  3BIT A;  1XNZ A;  2P99 A;  3L24 A;  3MX6 A;  3PKC A;  4U6W A;  4U75 A;  3ROR A;  2BHA A;  2B3L A;  1WY2 A;  2V3Z A;  3O5V A;  1YW9 A;  2B3H A;  3PKE A;  4U71 A;  3PKD A;  3QOC A;  2G6P A;  1QXZ A;  4HXX A;  4U1B A;  1WN1 A;  3PN9 A;  3IU9 A;  2Q8K A;  2P9A A;  2GG0 A;  3L7G A;  2GG9 A;  4ZWU A;  2Q94 A;  1WL6 A;  5E5B A;  2EA4 A;  1WBQ A;  2V3Y A;  4IU6 A;  2B3K A;  2GG5 A;  4FKC A;  4A6V A;  4IDY A;  1W7V A;  4S2T P;  4U6E A;  1QZY A;  4FO7 A;  3TB5 A;  1C27 A;  1N51 A;  4EGE A;  4QR8 A;  3FM3 A;  5JHU A;  5CIK A;  2GG3 A;  5CDV A;  4U6J A;  2V6C A;  1Y1N A;  1MAT A;  5E2C A;  3S6B A;  1CHM A;  5D6F A;  2GGC A;  2BHB A;  2HOW A;  4S2R P;  4KM3 A;  2ADU A;  1JAW A;  4R60 A;  1C23 A;  3PKA A;  1R58 A;  2GG8 A;  2BHD A;  4A6W A;  1KP0 A;  4FUK A;  2BB7 A;  2Q93 A;  1YVM A;  3TAV A;  4IKT A;  3CB5 A;  2BN7 A;  3OOO A;  1C21 A;  1C22 A;  2IW2 A;  2GU6 A;  3OVK A;  3I7M A;  4S00 A;  4RZZ A;  3PEB A;  1KQ0 A;  2Q92 A;  4Z7M A;  5CE6 A;  4JUQ A;  2V3X A;  2EVC A;  4IKS A;  2EVO A;  4FLL A;  3BIP A;  4U70 A;  4U73 A;  3Q6D A;  1WL9 A;  5CNX A;  3IL0 A;  3RVA A;  4IF7 A;  4ZWP A;  1WLR A;  3CTZ A;  5FCH A;  3FMQ A;  2NQ6 A;  2Q95 A;  3IU7 A;  1PV9 A;  4ZNG A;  2P98 A;  2BH3 A;  3CB6 A;  2GG2 A;  2BWU A;  2BWS A;  4ZWO A;  1XGM A;  2GA2 A;  5CLS A;  1R5G A;  4U76 A;  1XGS A;  4IKU A;  2MAT A;  4B28 A;  1O0X A;  3D27 A;  4FLJ A;  2BWT A;  3IU8 A;  1YJ3 A;  4U6C A;  4FLI A;  2NQ7 A;  2GU5 A;  1XGN A;  2EVM A;  4S01 A;  1BOA A;  2GU4 A;  2BWY A;  4MAT A;  4U69 A;  2OAZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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