4ZWUA

Crystal structure of organophosphate anhydrolase/prolidase mutant y212f, v342l, i215y
Total Genus 154
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
154
sequence length
439
structure length
435
Chain Sequence
NKLAVLYAEHIATLQKRTREIIERENLDGVVFHSGQAKRQFLDDMYYPFKVNPQFKAWLPVIDNPHCWIVANGTDKPKLIFYRPVDFWHKVEPNEYWADYFDIELLVKPDQVEKLLPYDKARFAYIGEYLEVAQALGFELMNPEPVMNFYHYHRAYKTQYELACMREANKIAVQGHKAARDAFFQGKSEFEIQQAYLLATQHSENDTPFGNYVALNENCAILHYTHFDRVAPATHRSFLIDAGANFNGYAADITRTYDFTGEGEFAELVATMKQHQIALCNQLAPGKLYGELHLDCHQRVAQTLSDFNIVNLSADEIVAKGITSTFFPHGLGHHIGLQLHDVGGFMADEQGAHQEPGHPFLRCTRKIEANQVFTIEPGLYFIDSLLGDLAATDNNQHINWDKVAELKPFGGIRIEDNIIVHEDSLENMTRELELD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords ORGANOPHOSPHATE ANHYDROLASE/PROLIDASE
publication title Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX.
pubmed doi rcsb
source organism Alteromonas sp.
molecule tags Hydrolase
total genus 154
structure length 435
sequence length 439
chains with identical sequence B
ec nomenclature ec 3.1.8.1: Aryldialkylphosphatase.
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 4zwuA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4zwuA02
3RVAA 2BWWA 4RZZA 1A16A 4S00A 2B3LA 2BHAA 2GGBA 4PV4A 3Q6DA 2BB7A 3FMQA 4FLLA 4IF7A 4IKSA 1MATA 2P98A 4U6CA 2BWXA 1QXYA 2GGCA 5D6FA 1WY2A 3CB5A 3PN9A 1WLRA 2BHCA 3BIPA 2OAZA 4ZWPA 1KQ0A 1XGMA 4MATA 5D6EA 2DFIA 1C23A 2GA2A 2V3XA 2MATA 1R5GA 3O5VA 5JHUA 2GU4A 3CTZA 1N51A 4U69A 1WBQA 4JUQA 3PKEA 4A6WA 3MX6A 1YW8A 4FO8A 1YJ3A 2EVCA 4ZNGA 3QOCA 2Q95A 2Q96A 1O0XA 2G6PA 4OOKA 3S6BA 1B59A 4S01A 2V3YA 5CDVA 2Q93A 3PKAA 4PNCA 2GTXA 2B3KA 4S2RP 4ZWOA 4U6ZA 1C27A 1KQ9A 1W7VA 4EGEA 4U6EA 4FKCA 2P9AA 2V3ZA 4B28A 2EA4A 2GZ5A 1C24A 2NQ7A 4HXXA 2BWSA 5CDLA 4FUKA 4U6WA 2V6CA 2GG8A 2EVMA 1Y1NA 3MATA 4IU6A 3BITA 5CE6A 5CIKA 1R5HA 1CHMA 5CDEA 2Q94A 5JFRA 3BIQA 2BN7A 1BN5A 2GU5A 3CB6A 1WL9A 2BH3A 1XGOA 2P99A 3D27A 4U6JA 3IU9A 4U70A 1W2MA 5E2CA 4FLKA 1C22A 4A6VA 2BHBA 2IW2A 4R60A 2BWUA 4KM3A 3MR1A 2BWYA 2GG0A 2EA2A 3PKBA 1XGSA 3IG4A 5JI6A 5FCFA 2BWVA 1WKMA 1WN1A 1QXWA 2GG3A 1YVMA 2HOWA 4U73A 4IKRA 4U76A 2GG9A 3FMRA 2GG2A 2GG7A 4QR8A 4U1BA 4IPAA 1R58A 3OVKA 2ZSGA 3TB5A 3TAVA 3OOOA 1PV9A 4ZWUA 4U75A 2B3HA 4IDYA 4IKTA 5FCHA 4RZYA 4S2TP 3RORA 3PEBA 1BOAA 1XNZA 4U71A 1KP0A 4RGZ1 1QXZA 5E5BA 2GU7A 5CLSA 1M35A 3L24A 4FO7A 2GG5A 1YW9A 4Z7MA 2BHDA 3L7GA 1JAWA 3IU8A 4IECA 2Q92A 1WL6A 5CNXA 1C21A 2OKNA 1YW7A 4IKUA 2GU6A 2NQ6A 3PKCA 1XGNA 1B6AA 2EVOA 4FLIA 3FM3A 3I7MA 2BWTA 3PKDA 2Q8KA 3IL0A 4FLJA 1QZYA 2ADUA 3IU7A
chains in the Genus database with same CATH superfamily
3RVAA 2BWWA 4RZZA 1A16A 4S00A 2B3LA 2BHAA 2GGBA 4PV4A 3Q6DA 2BB7A 3FMQA 4FLLA 4IF7A 4IKSA 1MATA 2P98A 4U6CA 2BWXA 1QXYA 2GGCA 5D6FA 1WY2A 3CB5A 3PN9A 1WLRA 2BHCA 3BIPA 2OAZA 4ZWPA 1KQ0A 1XGMA 4MATA 5D6EA 2DFIA 1C23A 2GA2A 2V3XA 2MATA 1R5GA 3O5VA 5JHUA 2GU4A 3CTZA 1N51A 4U69A 1WBQA 4JUQA 3PKEA 4A6WA 3MX6A 1YW8A 4FO8A 1YJ3A 2EVCA 4ZNGA 3QOCA 2Q95A 2Q96A 1O0XA 2G6PA 4OOKA 3S6BA 1B59A 4S01A 2V3YA 5CDVA 2Q93A 3PKAA 4PNCA 2GTXA 2B3KA 4S2RP 4ZWOA 4U6ZA 1C27A 1KQ9A 1W7VA 4EGEA 4U6EA 4FKCA 2P9AA 2V3ZA 4B28A 2EA4A 2GZ5A 1C24A 2NQ7A 4HXXA 2BWSA 5CDLA 4FUKA 4U6WA 2V6CA 2GG8A 2EVMA 1Y1NA 3MATA 4IU6A 3BITA 5CE6A 5CIKA 1R5HA 1CHMA 5CDEA 2Q94A 5JFRA 3BIQA 2BN7A 1BN5A 2GU5A 3CB6A 1WL9A 2BH3A 1XGOA 2P99A 3D27A 4U6JA 3IU9A 4U70A 1W2MA 5E2CA 4FLKA 1C22A 4A6VA 2BHBA 2IW2A 4R60A 2BWUA 4KM3A 3MR1A 2BWYA 2GG0A 2EA2A 3PKBA 1XGSA 3IG4A 5JI6A 5FCFA 2BWVA 1WKMA 1WN1A 1QXWA 2GG3A 1YVMA 2HOWA 4U73A 4IKRA 4U76A 2GG9A 3FMRA 2GG2A 2GG7A 4QR8A 4U1BA 4IPAA 1R58A 3OVKA 2ZSGA 3TB5A 3TAVA 3OOOA 1PV9A 4ZWUA 4U75A 2B3HA 4IDYA 4IKTA 5FCHA 4RZYA 4S2TP 3RORA 3PEBA 1BOAA 1XNZA 4U71A 1KP0A 4RGZ1 1QXZA 5E5BA 2GU7A 5CLSA 1M35A 3L24A 4FO7A 2GG5A 1YW9A 4Z7MA 2BHDA 3L7GA 1JAWA 3IU8A 4IECA 2Q92A 1WL6A 5CNXA 1C21A 2OKNA 1YW7A 4IKUA 2GU6A 2NQ6A 3PKCA 1XGNA 1B6AA 2EVOA 4FLIA 3FM3A 3I7MA 2BWTA 3PKDA 2Q8KA 3IL0A 4FLJA 1QZYA 2ADUA 3IU7A
chains in the Genus database with same CATH topology
3RVAA 2BWWA 4RZZA 1A16A 4S00A 2B3LA 2BHAA 2GGBA 4PV4A 3Q6DA 2BB7A 3FMQA 4FLLA 4IF7A 4IKSA 1MATA 2P98A 4U6CA 2BWXA 1QXYA 2GGCA 5D6FA 1WY2A 3CB5A 3PN9A 1WLRA 2BHCA 3BIPA 2OAZA 4ZWPA 1KQ0A 1XGMA 4MATA 5D6EA 2DFIA 1C23A 2GA2A 2V3XA 2MATA 1R5GA 3O5VA 5JHUA 2GU4A 3CTZA 1N51A 4U69A 1WBQA 4JUQA 3PKEA 4A6WA 3MX6A 1YW8A 4FO8A 1YJ3A 2EVCA 4ZNGA 3QOCA 2Q95A 2Q96A 1O0XA 2G6PA 4OOKA 3S6BA 1B59A 4S01A 2V3YA 5CDVA 2Q93A 3PKAA 4PNCA 2GTXA 2B3KA 4S2RP 4ZWOA 4U6ZA 1C27A 1KQ9A 1W7VA 4EGEA 4U6EA 4FKCA 2P9AA 2V3ZA 4B28A 2EA4A 2GZ5A 1C24A 2NQ7A 4HXXA 2BWSA 5CDLA 4FUKA 4U6WA 2V6CA 2GG8A 2EVMA 1Y1NA 3MATA 4IU6A 3BITA 5CE6A 5CIKA 1R5HA 1CHMA 5CDEA 2Q94A 5JFRA 3BIQA 2BN7A 1BN5A 2GU5A 3CB6A 1WL9A 2BH3A 1XGOA 2P99A 3D27A 4U6JA 3IU9A 4U70A 1W2MA 5E2CA 4FLKA 1C22A 4A6VA 2BHBA 2IW2A 4R60A 2BWUA 4KM3A 3MR1A 2BWYA 2GG0A 2EA2A 3PKBA 1XGSA 3IG4A 5JI6A 5FCFA 2BWVA 1WKMA 1WN1A 1QXWA 2GG3A 1YVMA 2HOWA 4U73A 4IKRA 4U76A 2GG9A 3FMRA 2GG2A 2GG7A 4QR8A 4U1BA 4IPAA 1R58A 3OVKA 2ZSGA 3TB5A 3TAVA 3OOOA 1PV9A 4ZWUA 4U75A 2B3HA 4IDYA 4IKTA 5FCHA 4RZYA 4S2TP 3RORA 3PEBA 1BOAA 1XNZA 4U71A 1KP0A 4RGZ1 1QXZA 5E5BA 2GU7A 5CLSA 1M35A 3L24A 4FO7A 2GG5A 1YW9A 4Z7MA 2BHDA 3L7GA 1JAWA 3IU8A 4IECA 2Q92A 1WL6A 5CNXA 1C21A 2OKNA 1YW7A 4IKUA 2GU6A 2NQ6A 3PKCA 1XGNA 1B6AA 2EVOA 4FLIA 3FM3A 3I7MA 2BWTA 3PKDA 2Q8KA 3IL0A 4FLJA 1QZYA 2ADUA 3IU7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3RVA A;  2BWW A;  4RZZ A;  1A16 A;  4S00 A;  2B3L A;  2BHA A;  2GGB A;  4PV4 A;  3Q6D A;  2BB7 A;  3FMQ A;  4FLL A;  4IF7 A;  4IKS A;  1MAT A;  2P98 A;  4U6C A;  2BWX A;  1QXY A;  2GGC A;  5D6F A;  1WY2 A;  3CB5 A;  3PN9 A;  1WLR A;  2BHC A;  3BIP A;  2OAZ A;  4ZWP A;  1KQ0 A;  1XGM A;  4MAT A;  5D6E A;  2DFI A;  1C23 A;  2GA2 A;  2V3X A;  2MAT A;  1R5G A;  3O5V A;  5JHU A;  2GU4 A;  3CTZ A;  1N51 A;  4U69 A;  1WBQ A;  4JUQ A;  3PKE A;  4A6W A;  3MX6 A;  1YW8 A;  4FO8 A;  1YJ3 A;  2EVC A;  4ZNG A;  3QOC A;  2Q95 A;  2Q96 A;  1O0X A;  2G6P A;  4OOK A;  3S6B A;  1B59 A;  4S01 A;  2V3Y A;  5CDV A;  2Q93 A;  3PKA A;  4PNC A;  2GTX A;  2B3K A;  4S2R P;  4ZWO A;  4U6Z A;  1C27 A;  1KQ9 A;  1W7V A;  4EGE A;  4U6E A;  4FKC A;  2P9A A;  2V3Z A;  4B28 A;  2EA4 A;  2GZ5 A;  1C24 A;  2NQ7 A;  4HXX A;  2BWS A;  5CDL A;  4FUK A;  4U6W A;  2V6C A;  2GG8 A;  2EVM A;  1Y1N A;  3MAT A;  4IU6 A;  3BIT A;  5CE6 A;  5CIK A;  1R5H A;  1CHM A;  5CDE A;  2Q94 A;  5JFR A;  3BIQ A;  2BN7 A;  1BN5 A;  2GU5 A;  3CB6 A;  1WL9 A;  2BH3 A;  1XGO A;  2P99 A;  3D27 A;  4U6J A;  3IU9 A;  4U70 A;  1W2M A;  5E2C A;  4FLK A;  1C22 A;  4A6V A;  2BHB A;  2IW2 A;  4R60 A;  2BWU A;  4KM3 A;  3MR1 A;  2BWY A;  2GG0 A;  2EA2 A;  3PKB A;  1XGS A;  3IG4 A;  5JI6 A;  5FCF A;  2BWV A;  1WKM A;  1WN1 A;  1QXW A;  2GG3 A;  1YVM A;  2HOW A;  4U73 A;  4IKR A;  4U76 A;  2GG9 A;  3FMR A;  2GG2 A;  2GG7 A;  4QR8 A;  4U1B A;  4IPA A;  1R58 A;  3OVK A;  2ZSG A;  3TB5 A;  3TAV A;  3OOO A;  1PV9 A;  4ZWU A;  4U75 A;  2B3H A;  4IDY A;  4IKT A;  5FCH A;  4RZY A;  4S2T P;  3ROR A;  3PEB A;  1BOA A;  1XNZ A;  4U71 A;  1KP0 A;  4RGZ 1;  1QXZ A;  5E5B A;  2GU7 A;  5CLS A;  1M35 A;  3L24 A;  4FO7 A;  2GG5 A;  1YW9 A;  4Z7M A;  2BHD A;  3L7G A;  1JAW A;  3IU8 A;  4IEC A;  2Q92 A;  1WL6 A;  5CNX A;  1C21 A;  2OKN A;  1YW7 A;  4IKU A;  2GU6 A;  2NQ6 A;  3PKC A;  1XGN A;  1B6A A;  2EVO A;  4FLI A;  3FM3 A;  3I7M A;  2BWT A;  3PKD A;  2Q8K A;  3IL0 A;  4FLJ A;  1QZY A;  2ADU A;  3IU7 A; 
#chains in the Genus database with same CATH topology
 3RVA A;  2BWW A;  4RZZ A;  1A16 A;  4S00 A;  2B3L A;  2BHA A;  2GGB A;  4PV4 A;  3Q6D A;  2BB7 A;  3FMQ A;  4FLL A;  4IF7 A;  4IKS A;  1MAT A;  2P98 A;  4U6C A;  2BWX A;  1QXY A;  2GGC A;  5D6F A;  1WY2 A;  3CB5 A;  3PN9 A;  1WLR A;  2BHC A;  3BIP A;  2OAZ A;  4ZWP A;  1KQ0 A;  1XGM A;  4MAT A;  5D6E A;  2DFI A;  1C23 A;  2GA2 A;  2V3X A;  2MAT A;  1R5G A;  3O5V A;  5JHU A;  2GU4 A;  3CTZ A;  1N51 A;  4U69 A;  1WBQ A;  4JUQ A;  3PKE A;  4A6W A;  3MX6 A;  1YW8 A;  4FO8 A;  1YJ3 A;  2EVC A;  4ZNG A;  3QOC A;  2Q95 A;  2Q96 A;  1O0X A;  2G6P A;  4OOK A;  3S6B A;  1B59 A;  4S01 A;  2V3Y A;  5CDV A;  2Q93 A;  3PKA A;  4PNC A;  2GTX A;  2B3K A;  4S2R P;  4ZWO A;  4U6Z A;  1C27 A;  1KQ9 A;  1W7V A;  4EGE A;  4U6E A;  4FKC A;  2P9A A;  2V3Z A;  4B28 A;  2EA4 A;  2GZ5 A;  1C24 A;  2NQ7 A;  4HXX A;  2BWS A;  5CDL A;  4FUK A;  4U6W A;  2V6C A;  2GG8 A;  2EVM A;  1Y1N A;  3MAT A;  4IU6 A;  3BIT A;  5CE6 A;  5CIK A;  1R5H A;  1CHM A;  5CDE A;  2Q94 A;  5JFR A;  3BIQ A;  2BN7 A;  1BN5 A;  2GU5 A;  3CB6 A;  1WL9 A;  2BH3 A;  1XGO A;  2P99 A;  3D27 A;  4U6J A;  3IU9 A;  4U70 A;  1W2M A;  5E2C A;  4FLK A;  1C22 A;  4A6V A;  2BHB A;  2IW2 A;  4R60 A;  2BWU A;  4KM3 A;  3MR1 A;  2BWY A;  2GG0 A;  2EA2 A;  3PKB A;  1XGS A;  3IG4 A;  5JI6 A;  5FCF A;  2BWV A;  1WKM A;  1WN1 A;  1QXW A;  2GG3 A;  1YVM A;  2HOW A;  4U73 A;  4IKR A;  4U76 A;  2GG9 A;  3FMR A;  2GG2 A;  2GG7 A;  4QR8 A;  4U1B A;  4IPA A;  1R58 A;  3OVK A;  2ZSG A;  3TB5 A;  3TAV A;  3OOO A;  1PV9 A;  4ZWU A;  4U75 A;  2B3H A;  4IDY A;  4IKT A;  5FCH A;  4RZY A;  4S2T P;  3ROR A;  3PEB A;  1BOA A;  1XNZ A;  4U71 A;  1KP0 A;  4RGZ 1;  1QXZ A;  5E5B A;  2GU7 A;  5CLS A;  1M35 A;  3L24 A;  4FO7 A;  2GG5 A;  1YW9 A;  4Z7M A;  2BHD A;  3L7G A;  1JAW A;  3IU8 A;  4IEC A;  2Q92 A;  1WL6 A;  5CNX A;  1C21 A;  2OKN A;  1YW7 A;  4IKU A;  2GU6 A;  2NQ6 A;  3PKC A;  1XGN A;  1B6A A;  2EVO A;  4FLI A;  3FM3 A;  3I7M A;  2BWT A;  3PKD A;  2Q8K A;  3IL0 A;  4FLJ A;  1QZY A;  2ADU A;  3IU7 A; 
#chains in the Genus database with same CATH homology
 3RVA A;  2BWW A;  4RZZ A;  1A16 A;  4S00 A;  2B3L A;  2BHA A;  2GGB A;  4PV4 A;  3Q6D A;  2BB7 A;  3FMQ A;  4FLL A;  4IF7 A;  4IKS A;  1MAT A;  2P98 A;  4U6C A;  2BWX A;  1QXY A;  2GGC A;  5D6F A;  1WY2 A;  3CB5 A;  3PN9 A;  1WLR A;  2BHC A;  3BIP A;  2OAZ A;  4ZWP A;  1KQ0 A;  1XGM A;  4MAT A;  5D6E A;  2DFI A;  1C23 A;  2GA2 A;  2V3X A;  2MAT A;  1R5G A;  3O5V A;  5JHU A;  2GU4 A;  3CTZ A;  1N51 A;  4U69 A;  1WBQ A;  4JUQ A;  3PKE A;  4A6W A;  3MX6 A;  1YW8 A;  4FO8 A;  1YJ3 A;  2EVC A;  4ZNG A;  3QOC A;  2Q95 A;  2Q96 A;  1O0X A;  2G6P A;  4OOK A;  3S6B A;  1B59 A;  4S01 A;  2V3Y A;  5CDV A;  2Q93 A;  3PKA A;  4PNC A;  2GTX A;  2B3K A;  4S2R P;  4ZWO A;  4U6Z A;  1C27 A;  1KQ9 A;  1W7V A;  4EGE A;  4U6E A;  4FKC A;  2P9A A;  2V3Z A;  4B28 A;  2EA4 A;  2GZ5 A;  1C24 A;  2NQ7 A;  4HXX A;  2BWS A;  5CDL A;  4FUK A;  4U6W A;  2V6C A;  2GG8 A;  2EVM A;  1Y1N A;  3MAT A;  4IU6 A;  3BIT A;  5CE6 A;  5CIK A;  1R5H A;  1CHM A;  5CDE A;  2Q94 A;  5JFR A;  3BIQ A;  2BN7 A;  1BN5 A;  2GU5 A;  3CB6 A;  1WL9 A;  2BH3 A;  1XGO A;  2P99 A;  3D27 A;  4U6J A;  3IU9 A;  4U70 A;  1W2M A;  5E2C A;  4FLK A;  1C22 A;  4A6V A;  2BHB A;  2IW2 A;  4R60 A;  2BWU A;  4KM3 A;  3MR1 A;  2BWY A;  2GG0 A;  2EA2 A;  3PKB A;  1XGS A;  3IG4 A;  5JI6 A;  5FCF A;  2BWV A;  1WKM A;  1WN1 A;  1QXW A;  2GG3 A;  1YVM A;  2HOW A;  4U73 A;  4IKR A;  4U76 A;  2GG9 A;  3FMR A;  2GG2 A;  2GG7 A;  4QR8 A;  4U1B A;  4IPA A;  1R58 A;  3OVK A;  2ZSG A;  3TB5 A;  3TAV A;  3OOO A;  1PV9 A;  4ZWU A;  4U75 A;  2B3H A;  4IDY A;  4IKT A;  5FCH A;  4RZY A;  4S2T P;  3ROR A;  3PEB A;  1BOA A;  1XNZ A;  4U71 A;  1KP0 A;  4RGZ 1;  1QXZ A;  5E5B A;  2GU7 A;  5CLS A;  1M35 A;  3L24 A;  4FO7 A;  2GG5 A;  1YW9 A;  4Z7M A;  2BHD A;  3L7G A;  1JAW A;  3IU8 A;  4IEC A;  2Q92 A;  1WL6 A;  5CNX A;  1C21 A;  2OKN A;  1YW7 A;  4IKU A;  2GU6 A;  2NQ6 A;  3PKC A;  1XGN A;  1B6A A;  2EVO A;  4FLI A;  3FM3 A;  3I7M A;  2BWT A;  3PKD A;  2Q8K A;  3IL0 A;  4FLJ A;  1QZY A;  2ADU A;  3IU7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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