2IW2A

Crystal structure of human prolidase
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
477
structure length
477
Chain Sequence
GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords XAA-PRO DIPEPTIDASE
publication title Crystal Structure of Human Prolidase: The Molecular Basis of Pd Disease
rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 170
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2006-06-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2iw2A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2iw2A02
2ADUA 5CDLA 3BIQA 1B59A 4EGEA 4JUQA 4U75A 1W2MA 1W7VA 4FKCA 4FLJA 2GG5A 1MATA 2GG3A 3PKDA 2B3KA 4IPAA 5CE6A 4OOKA 4U71A 4FLLA 1PV9A 1C23A 3PKCA 4FO8A 4FLIA 2EA2A 2BWUA 2IW2A 4Z7MA 1R5HA 4R60A 4ZWPA 5FCHA 4IECA 4U73A 2GG2A 4U6EA 1XNZA 4U6ZA 1WY2A 4IF7A 5JI6A 4IKRA 1QZYA 3BITA 2GU6A 2Q96A 1N51A 2BWWA 3D27A 4S2TP 1YW8A 2EVCA 1WBQA 3O5VA 5CIKA 2BWTA 4RZZA 1BOAA 3CTZA 4B28A 5CDVA 2GU4A 2Q93A 4MATA 2G6PA 2V3ZA 5E5BA 3RORA 3IU9A 5JHUA 4PV4A 2BWSA 4RGZ1 2BWXA 2NQ6A 2BH3A 5CNXA 3PN9A 3MATA 1KQ9A 2GGCA 1BN5A 1XGOA 2Q94A 2GGBA 1YJ3A 3TB5A 4U70A 4ZWUA 3FM3A 1C21A 3OVKA 3IU7A 5FCFA 2EVOA 1C24A 3PKBA 2EVMA 3QOCA 2B3LA 1R58A 2MATA 2BB7A 2P9AA 4FUKA 1YVMA 2Q8KA 2GZ5A 3PEBA 1Y1NA 4A6WA 2BN7A 1R5GA 2GA2A 3CB5A 1C22A 2DFIA 2GG0A 3FMQA 1YW7A 4ZWOA 5CLSA 2V3XA 1KQ0A 4U6JA 5JFRA 4A6VA 3L24A 1QXYA 4S00A 1M35A 1WKMA 1B6AA 1JAWA 4IKSA 2BWYA 2OAZA 4S01A 3IG4A 1KP0A 1XGSA 2NQ7A 2Q92A 3RVAA 5CDEA 1QXWA 2GG9A 4U6CA 4FO7A 1WN1A 1C27A 2EA4A 4FLKA 1O0XA 4S2RP 2Q95A 5E2CA 2V6CA 4U76A 3IU8A 1A16A 2ZSGA 4U69A 5D6EA 2BHCA 2BHAA 2P99A 4QR8A 1YW9A 3S6BA 1XGNA 4IU6A 3I7MA 2P98A 1WL6A 2BWVA 4IDYA 4KM3A 2BHDA 2GG7A 1WL9A 4RZYA 1XGMA 3PKAA 2BHBA 3IL0A 2GU5A 1QXZA 2GTXA 3PKEA 3Q6DA 4HXXA 1CHMA 1WLRA 4ZNGA 3MR1A 5D6FA 3TAVA 2OKNA 2HOWA 2GG8A 3OOOA 4IKUA 4U1BA 4U6WA 3FMRA 3L7GA 2GU7A 4PNCA 2B3HA 2V3YA 3MX6A 3BIPA 3CB6A 4IKTA
chains in the Genus database with same CATH superfamily
2ADUA 5CDLA 3BIQA 1B59A 4EGEA 4JUQA 4U75A 1W2MA 1W7VA 4FKCA 4FLJA 2GG5A 1MATA 2GG3A 3PKDA 2B3KA 4IPAA 5CE6A 4OOKA 4U71A 4FLLA 1PV9A 1C23A 3PKCA 4FO8A 4FLIA 2EA2A 2BWUA 2IW2A 4Z7MA 1R5HA 4R60A 4ZWPA 5FCHA 4IECA 4U73A 2GG2A 4U6EA 1XNZA 4U6ZA 1WY2A 4IF7A 5JI6A 4IKRA 1QZYA 3BITA 2GU6A 2Q96A 1N51A 2BWWA 3D27A 4S2TP 1YW8A 2EVCA 1WBQA 3O5VA 5CIKA 2BWTA 4RZZA 1BOAA 3CTZA 4B28A 5CDVA 2GU4A 2Q93A 4MATA 2G6PA 2V3ZA 5E5BA 3RORA 3IU9A 5JHUA 4PV4A 2BWSA 4RGZ1 2BWXA 2NQ6A 2BH3A 5CNXA 3PN9A 3MATA 1KQ9A 2GGCA 1BN5A 1XGOA 2Q94A 2GGBA 1YJ3A 3TB5A 4U70A 4ZWUA 3FM3A 1C21A 3OVKA 3IU7A 5FCFA 2EVOA 1C24A 3PKBA 2EVMA 3QOCA 2B3LA 1R58A 2MATA 2BB7A 2P9AA 4FUKA 1YVMA 2Q8KA 2GZ5A 3PEBA 1Y1NA 4A6WA 2BN7A 1R5GA 2GA2A 3CB5A 1C22A 2DFIA 2GG0A 3FMQA 1YW7A 4ZWOA 5CLSA 2V3XA 1KQ0A 4U6JA 5JFRA 4A6VA 3L24A 1QXYA 4S00A 1M35A 1WKMA 1B6AA 1JAWA 4IKSA 2BWYA 2OAZA 4S01A 3IG4A 1KP0A 1XGSA 2NQ7A 2Q92A 3RVAA 5CDEA 1QXWA 2GG9A 4U6CA 4FO7A 1WN1A 1C27A 2EA4A 4FLKA 1O0XA 4S2RP 2Q95A 5E2CA 2V6CA 4U76A 3IU8A 1A16A 2ZSGA 4U69A 5D6EA 2BHCA 2BHAA 2P99A 4QR8A 1YW9A 3S6BA 1XGNA 4IU6A 3I7MA 2P98A 1WL6A 2BWVA 4IDYA 4KM3A 2BHDA 2GG7A 1WL9A 4RZYA 1XGMA 3PKAA 2BHBA 3IL0A 2GU5A 1QXZA 2GTXA 3PKEA 3Q6DA 4HXXA 1CHMA 1WLRA 4ZNGA 3MR1A 5D6FA 3TAVA 2OKNA 2HOWA 2GG8A 3OOOA 4IKUA 4U1BA 4U6WA 3FMRA 3L7GA 2GU7A 4PNCA 2B3HA 2V3YA 3MX6A 3BIPA 3CB6A 4IKTA
chains in the Genus database with same CATH topology
2ADUA 5CDLA 3BIQA 1B59A 4EGEA 4JUQA 4U75A 1W2MA 1W7VA 4FKCA 4FLJA 2GG5A 1MATA 2GG3A 3PKDA 2B3KA 4IPAA 5CE6A 4OOKA 4U71A 4FLLA 1PV9A 1C23A 3PKCA 4FO8A 4FLIA 2EA2A 2BWUA 2IW2A 4Z7MA 1R5HA 4R60A 4ZWPA 5FCHA 4IECA 4U73A 2GG2A 4U6EA 1XNZA 4U6ZA 1WY2A 4IF7A 5JI6A 4IKRA 1QZYA 3BITA 2GU6A 2Q96A 1N51A 2BWWA 3D27A 4S2TP 1YW8A 2EVCA 1WBQA 3O5VA 5CIKA 2BWTA 4RZZA 1BOAA 3CTZA 4B28A 5CDVA 2GU4A 2Q93A 4MATA 2G6PA 2V3ZA 5E5BA 3RORA 3IU9A 5JHUA 4PV4A 2BWSA 4RGZ1 2BWXA 2NQ6A 2BH3A 5CNXA 3PN9A 3MATA 1KQ9A 2GGCA 1BN5A 1XGOA 2Q94A 2GGBA 1YJ3A 3TB5A 4U70A 4ZWUA 3FM3A 1C21A 3OVKA 3IU7A 5FCFA 2EVOA 1C24A 3PKBA 2EVMA 3QOCA 2B3LA 1R58A 2MATA 2BB7A 2P9AA 4FUKA 1YVMA 2Q8KA 2GZ5A 3PEBA 1Y1NA 4A6WA 2BN7A 1R5GA 2GA2A 3CB5A 1C22A 2DFIA 2GG0A 3FMQA 1YW7A 4ZWOA 5CLSA 2V3XA 1KQ0A 4U6JA 5JFRA 4A6VA 3L24A 1QXYA 4S00A 1M35A 1WKMA 1B6AA 1JAWA 4IKSA 2BWYA 2OAZA 4S01A 3IG4A 1KP0A 1XGSA 2NQ7A 2Q92A 3RVAA 5CDEA 1QXWA 2GG9A 4U6CA 4FO7A 1WN1A 1C27A 2EA4A 4FLKA 1O0XA 4S2RP 2Q95A 5E2CA 2V6CA 4U76A 3IU8A 1A16A 2ZSGA 4U69A 5D6EA 2BHCA 2BHAA 2P99A 4QR8A 1YW9A 3S6BA 1XGNA 4IU6A 3I7MA 2P98A 1WL6A 2BWVA 4IDYA 4KM3A 2BHDA 2GG7A 1WL9A 4RZYA 1XGMA 3PKAA 2BHBA 3IL0A 2GU5A 1QXZA 2GTXA 3PKEA 3Q6DA 4HXXA 1CHMA 1WLRA 4ZNGA 3MR1A 5D6FA 3TAVA 2OKNA 2HOWA 2GG8A 3OOOA 4IKUA 4U1BA 4U6WA 3FMRA 3L7GA 2GU7A 4PNCA 2B3HA 2V3YA 3MX6A 3BIPA 3CB6A 4IKTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ADU A;  5CDL A;  3BIQ A;  1B59 A;  4EGE A;  4JUQ A;  4U75 A;  1W2M A;  1W7V A;  4FKC A;  4FLJ A;  2GG5 A;  1MAT A;  2GG3 A;  3PKD A;  2B3K A;  4IPA A;  5CE6 A;  4OOK A;  4U71 A;  4FLL A;  1PV9 A;  1C23 A;  3PKC A;  4FO8 A;  4FLI A;  2EA2 A;  2BWU A;  2IW2 A;  4Z7M A;  1R5H A;  4R60 A;  4ZWP A;  5FCH A;  4IEC A;  4U73 A;  2GG2 A;  4U6E A;  1XNZ A;  4U6Z A;  1WY2 A;  4IF7 A;  5JI6 A;  4IKR A;  1QZY A;  3BIT A;  2GU6 A;  2Q96 A;  1N51 A;  2BWW A;  3D27 A;  4S2T P;  1YW8 A;  2EVC A;  1WBQ A;  3O5V A;  5CIK A;  2BWT A;  4RZZ A;  1BOA A;  3CTZ A;  4B28 A;  5CDV A;  2GU4 A;  2Q93 A;  4MAT A;  2G6P A;  2V3Z A;  5E5B A;  3ROR A;  3IU9 A;  5JHU A;  4PV4 A;  2BWS A;  4RGZ 1;  2BWX A;  2NQ6 A;  2BH3 A;  5CNX A;  3PN9 A;  3MAT A;  1KQ9 A;  2GGC A;  1BN5 A;  1XGO A;  2Q94 A;  2GGB A;  1YJ3 A;  3TB5 A;  4U70 A;  4ZWU A;  3FM3 A;  1C21 A;  3OVK A;  3IU7 A;  5FCF A;  2EVO A;  1C24 A;  3PKB A;  2EVM A;  3QOC A;  2B3L A;  1R58 A;  2MAT A;  2BB7 A;  2P9A A;  4FUK A;  1YVM A;  2Q8K A;  2GZ5 A;  3PEB A;  1Y1N A;  4A6W A;  2BN7 A;  1R5G A;  2GA2 A;  3CB5 A;  1C22 A;  2DFI A;  2GG0 A;  3FMQ A;  1YW7 A;  4ZWO A;  5CLS A;  2V3X A;  1KQ0 A;  4U6J A;  5JFR A;  4A6V A;  3L24 A;  1QXY A;  4S00 A;  1M35 A;  1WKM A;  1B6A A;  1JAW A;  4IKS A;  2BWY A;  2OAZ A;  4S01 A;  3IG4 A;  1KP0 A;  1XGS A;  2NQ7 A;  2Q92 A;  3RVA A;  5CDE A;  1QXW A;  2GG9 A;  4U6C A;  4FO7 A;  1WN1 A;  1C27 A;  2EA4 A;  4FLK A;  1O0X A;  4S2R P;  2Q95 A;  5E2C A;  2V6C A;  4U76 A;  3IU8 A;  1A16 A;  2ZSG A;  4U69 A;  5D6E A;  2BHC A;  2BHA A;  2P99 A;  4QR8 A;  1YW9 A;  3S6B A;  1XGN A;  4IU6 A;  3I7M A;  2P98 A;  1WL6 A;  2BWV A;  4IDY A;  4KM3 A;  2BHD A;  2GG7 A;  1WL9 A;  4RZY A;  1XGM A;  3PKA A;  2BHB A;  3IL0 A;  2GU5 A;  1QXZ A;  2GTX A;  3PKE A;  3Q6D A;  4HXX A;  1CHM A;  1WLR A;  4ZNG A;  3MR1 A;  5D6F A;  3TAV A;  2OKN A;  2HOW A;  2GG8 A;  3OOO A;  4IKU A;  4U1B A;  4U6W A;  3FMR A;  3L7G A;  2GU7 A;  4PNC A;  2B3H A;  2V3Y A;  3MX6 A;  3BIP A;  3CB6 A;  4IKT A; 
#chains in the Genus database with same CATH topology
 2ADU A;  5CDL A;  3BIQ A;  1B59 A;  4EGE A;  4JUQ A;  4U75 A;  1W2M A;  1W7V A;  4FKC A;  4FLJ A;  2GG5 A;  1MAT A;  2GG3 A;  3PKD A;  2B3K A;  4IPA A;  5CE6 A;  4OOK A;  4U71 A;  4FLL A;  1PV9 A;  1C23 A;  3PKC A;  4FO8 A;  4FLI A;  2EA2 A;  2BWU A;  2IW2 A;  4Z7M A;  1R5H A;  4R60 A;  4ZWP A;  5FCH A;  4IEC A;  4U73 A;  2GG2 A;  4U6E A;  1XNZ A;  4U6Z A;  1WY2 A;  4IF7 A;  5JI6 A;  4IKR A;  1QZY A;  3BIT A;  2GU6 A;  2Q96 A;  1N51 A;  2BWW A;  3D27 A;  4S2T P;  1YW8 A;  2EVC A;  1WBQ A;  3O5V A;  5CIK A;  2BWT A;  4RZZ A;  1BOA A;  3CTZ A;  4B28 A;  5CDV A;  2GU4 A;  2Q93 A;  4MAT A;  2G6P A;  2V3Z A;  5E5B A;  3ROR A;  3IU9 A;  5JHU A;  4PV4 A;  2BWS A;  4RGZ 1;  2BWX A;  2NQ6 A;  2BH3 A;  5CNX A;  3PN9 A;  3MAT A;  1KQ9 A;  2GGC A;  1BN5 A;  1XGO A;  2Q94 A;  2GGB A;  1YJ3 A;  3TB5 A;  4U70 A;  4ZWU A;  3FM3 A;  1C21 A;  3OVK A;  3IU7 A;  5FCF A;  2EVO A;  1C24 A;  3PKB A;  2EVM A;  3QOC A;  2B3L A;  1R58 A;  2MAT A;  2BB7 A;  2P9A A;  4FUK A;  1YVM A;  2Q8K A;  2GZ5 A;  3PEB A;  1Y1N A;  4A6W A;  2BN7 A;  1R5G A;  2GA2 A;  3CB5 A;  1C22 A;  2DFI A;  2GG0 A;  3FMQ A;  1YW7 A;  4ZWO A;  5CLS A;  2V3X A;  1KQ0 A;  4U6J A;  5JFR A;  4A6V A;  3L24 A;  1QXY A;  4S00 A;  1M35 A;  1WKM A;  1B6A A;  1JAW A;  4IKS A;  2BWY A;  2OAZ A;  4S01 A;  3IG4 A;  1KP0 A;  1XGS A;  2NQ7 A;  2Q92 A;  3RVA A;  5CDE A;  1QXW A;  2GG9 A;  4U6C A;  4FO7 A;  1WN1 A;  1C27 A;  2EA4 A;  4FLK A;  1O0X A;  4S2R P;  2Q95 A;  5E2C A;  2V6C A;  4U76 A;  3IU8 A;  1A16 A;  2ZSG A;  4U69 A;  5D6E A;  2BHC A;  2BHA A;  2P99 A;  4QR8 A;  1YW9 A;  3S6B A;  1XGN A;  4IU6 A;  3I7M A;  2P98 A;  1WL6 A;  2BWV A;  4IDY A;  4KM3 A;  2BHD A;  2GG7 A;  1WL9 A;  4RZY A;  1XGM A;  3PKA A;  2BHB A;  3IL0 A;  2GU5 A;  1QXZ A;  2GTX A;  3PKE A;  3Q6D A;  4HXX A;  1CHM A;  1WLR A;  4ZNG A;  3MR1 A;  5D6F A;  3TAV A;  2OKN A;  2HOW A;  2GG8 A;  3OOO A;  4IKU A;  4U1B A;  4U6W A;  3FMR A;  3L7G A;  2GU7 A;  4PNC A;  2B3H A;  2V3Y A;  3MX6 A;  3BIP A;  3CB6 A;  4IKT A; 
#chains in the Genus database with same CATH homology
 2ADU A;  5CDL A;  3BIQ A;  1B59 A;  4EGE A;  4JUQ A;  4U75 A;  1W2M A;  1W7V A;  4FKC A;  4FLJ A;  2GG5 A;  1MAT A;  2GG3 A;  3PKD A;  2B3K A;  4IPA A;  5CE6 A;  4OOK A;  4U71 A;  4FLL A;  1PV9 A;  1C23 A;  3PKC A;  4FO8 A;  4FLI A;  2EA2 A;  2BWU A;  2IW2 A;  4Z7M A;  1R5H A;  4R60 A;  4ZWP A;  5FCH A;  4IEC A;  4U73 A;  2GG2 A;  4U6E A;  1XNZ A;  4U6Z A;  1WY2 A;  4IF7 A;  5JI6 A;  4IKR A;  1QZY A;  3BIT A;  2GU6 A;  2Q96 A;  1N51 A;  2BWW A;  3D27 A;  4S2T P;  1YW8 A;  2EVC A;  1WBQ A;  3O5V A;  5CIK A;  2BWT A;  4RZZ A;  1BOA A;  3CTZ A;  4B28 A;  5CDV A;  2GU4 A;  2Q93 A;  4MAT A;  2G6P A;  2V3Z A;  5E5B A;  3ROR A;  3IU9 A;  5JHU A;  4PV4 A;  2BWS A;  4RGZ 1;  2BWX A;  2NQ6 A;  2BH3 A;  5CNX A;  3PN9 A;  3MAT A;  1KQ9 A;  2GGC A;  1BN5 A;  1XGO A;  2Q94 A;  2GGB A;  1YJ3 A;  3TB5 A;  4U70 A;  4ZWU A;  3FM3 A;  1C21 A;  3OVK A;  3IU7 A;  5FCF A;  2EVO A;  1C24 A;  3PKB A;  2EVM A;  3QOC A;  2B3L A;  1R58 A;  2MAT A;  2BB7 A;  2P9A A;  4FUK A;  1YVM A;  2Q8K A;  2GZ5 A;  3PEB A;  1Y1N A;  4A6W A;  2BN7 A;  1R5G A;  2GA2 A;  3CB5 A;  1C22 A;  2DFI A;  2GG0 A;  3FMQ A;  1YW7 A;  4ZWO A;  5CLS A;  2V3X A;  1KQ0 A;  4U6J A;  5JFR A;  4A6V A;  3L24 A;  1QXY A;  4S00 A;  1M35 A;  1WKM A;  1B6A A;  1JAW A;  4IKS A;  2BWY A;  2OAZ A;  4S01 A;  3IG4 A;  1KP0 A;  1XGS A;  2NQ7 A;  2Q92 A;  3RVA A;  5CDE A;  1QXW A;  2GG9 A;  4U6C A;  4FO7 A;  1WN1 A;  1C27 A;  2EA4 A;  4FLK A;  1O0X A;  4S2R P;  2Q95 A;  5E2C A;  2V6C A;  4U76 A;  3IU8 A;  1A16 A;  2ZSG A;  4U69 A;  5D6E A;  2BHC A;  2BHA A;  2P99 A;  4QR8 A;  1YW9 A;  3S6B A;  1XGN A;  4IU6 A;  3I7M A;  2P98 A;  1WL6 A;  2BWV A;  4IDY A;  4KM3 A;  2BHD A;  2GG7 A;  1WL9 A;  4RZY A;  1XGM A;  3PKA A;  2BHB A;  3IL0 A;  2GU5 A;  1QXZ A;  2GTX A;  3PKE A;  3Q6D A;  4HXX A;  1CHM A;  1WLR A;  4ZNG A;  3MR1 A;  5D6F A;  3TAV A;  2OKN A;  2HOW A;  2GG8 A;  3OOO A;  4IKU A;  4U1B A;  4U6W A;  3FMR A;  3L7G A;  2GU7 A;  4PNC A;  2B3H A;  2V3Y A;  3MX6 A;  3BIP A;  3CB6 A;  4IKT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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