2IW2A

Crystal structure of human prolidase
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
477
structure length
477
Chain Sequence
b'GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords XAA-PRO DIPEPTIDASE
publication title Crystal Structure of Human Prolidase: The Molecular Basis of Pd Disease
rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 170
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2006-06-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2iw2A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2iw2A02
4PV4A 4S2TP 1CHMA 4U71A 4IDYA 3CB5A 1C23A 2BN7A 1MATA 4U70A 1YW8A 5CE6A 1W2MA 1WN1A 1C27A 1YW7A 2P9AA 1A16A 4FO8A 4U73A 4FLJA 2NQ7A 5CIKA 4ZNGA 1B59A 2GU5A 2DFIA 4MATA 2GA2A 3IU7A 4FLLA 5JHUA 4IKSA 2GG8A 3FMRA 1C24A 1PV9A 1XGSA 2MATA 2P98A 4FUKA 3CB6A 4U75A 2BWTA 2Q94A 1C21A 2B3HA 1R5GA 2P99A 1BOAA 4IECA 5E5BA 3IU9A 4IKUA 3IU8A 2HOWA 1YJ3A 2Q92A 3PEBA 4FLKA 4A6VA 4RZZA 4B28A 5CDVA 1KP0A 4ZWPA 2NQ6A 2Q93A 4U6EA 2GG3A 5FCHA 3L24A 3BITA 4A6WA 1B6AA 3I7MA 1QZYA 1BN5A 3BIPA 1WY2A 3FM3A 2EVMA 2OKNA 4S2RP 1XGNA 4EGEA 4FO7A 3MR1A 2Q8KA 4U69A 5CDEA 2BWUA 4IU6A 1WL6A 3IG4A 3OVKA 3PKAA 4JUQA 3OOOA 4U6JA 3TB5A 5JI6A 2BHBA 1R5HA 1KQ9A 4RZYA 2B3KA 1R58A 2OAZA 2V3XA 5FCFA 1N51A 5E2CA 2GZ5A 3PKCA 4ZWUA 2EA4A 4HXXA 3RORA 2Q96A 1XGMA 4U6CA 3BIQA 4FKCA 4IKRA 1WBQA 5CLSA 1O0XA 3Q6DA 4FLIA 5CDLA 2GGBA 2GU7A 3CTZA 4U6ZA 3TAVA 4S01A 2EA2A 1KQ0A 2GTXA 3MX6A 3MATA 2GG9A 3D27A 2V6CA 2BWSA 1QXZA 2B3LA 2GG7A 2GG5A 4IF7A 4IPAA 1M35A 1JAWA 2GG2A 1Y1NA 2BWVA 4R60A 1W7VA 2BB7A 4QR8A 3IL0A 1WL9A 1QXWA 2BHCA 5JFRA 2BH3A 4RGZ1 2GU6A 3FMQA 5CNXA 2V3YA 2BWXA 2G6PA 2ADUA 2EVOA 4Z7MA 3PKEA 4S00A 1C22A 4IKTA 2GGCA 4KM3A 4U1BA 1XGOA 4U6WA 3PKBA 1WLRA 2BHDA 2BHAA 4U76A 5D6EA 2IW2A 1XNZA 2GG0A 2Q95A 2EVCA 1YW9A 3S6BA 1WKMA 1YVMA 2GU4A 3L7GA 2BWWA 3QOCA 3O5VA 4PNCA 4OOKA 3PN9A 4ZWOA 2BWYA 2V3ZA 2ZSGA 5D6FA 3RVAA 1QXYA 3PKDA
chains in the Genus database with same CATH superfamily
4PV4A 4S2TP 1CHMA 4U71A 4IDYA 3CB5A 1C23A 2BN7A 1MATA 4U70A 1YW8A 5CE6A 1W2MA 1WN1A 1C27A 1YW7A 2P9AA 1A16A 4FO8A 4U73A 4FLJA 2NQ7A 5CIKA 4ZNGA 1B59A 2GU5A 2DFIA 4MATA 2GA2A 3IU7A 4FLLA 5JHUA 4IKSA 2GG8A 3FMRA 1C24A 1PV9A 1XGSA 2MATA 2P98A 4FUKA 3CB6A 4U75A 2BWTA 2Q94A 1C21A 2B3HA 1R5GA 2P99A 1BOAA 4IECA 5E5BA 3IU9A 4IKUA 3IU8A 2HOWA 1YJ3A 2Q92A 3PEBA 4FLKA 4A6VA 4RZZA 4B28A 5CDVA 1KP0A 4ZWPA 2NQ6A 2Q93A 4U6EA 2GG3A 5FCHA 3L24A 3BITA 4A6WA 1B6AA 3I7MA 1QZYA 1BN5A 3BIPA 1WY2A 3FM3A 2EVMA 2OKNA 4S2RP 1XGNA 4EGEA 4FO7A 3MR1A 2Q8KA 4U69A 5CDEA 2BWUA 4IU6A 1WL6A 3IG4A 3OVKA 3PKAA 4JUQA 3OOOA 4U6JA 3TB5A 5JI6A 2BHBA 1R5HA 1KQ9A 4RZYA 2B3KA 1R58A 2OAZA 2V3XA 5FCFA 1N51A 5E2CA 2GZ5A 3PKCA 4ZWUA 2EA4A 4HXXA 3RORA 2Q96A 1XGMA 4U6CA 3BIQA 4FKCA 4IKRA 1WBQA 5CLSA 1O0XA 3Q6DA 4FLIA 5CDLA 2GGBA 2GU7A 3CTZA 4U6ZA 3TAVA 4S01A 2EA2A 1KQ0A 2GTXA 3MX6A 3MATA 2GG9A 3D27A 2V6CA 2BWSA 1QXZA 2B3LA 2GG7A 2GG5A 4IF7A 4IPAA 1M35A 1JAWA 2GG2A 1Y1NA 2BWVA 4R60A 1W7VA 2BB7A 4QR8A 3IL0A 1WL9A 1QXWA 2BHCA 5JFRA 2BH3A 4RGZ1 2GU6A 3FMQA 5CNXA 2V3YA 2BWXA 2G6PA 2ADUA 2EVOA 4Z7MA 3PKEA 4S00A 1C22A 4IKTA 2GGCA 4KM3A 4U1BA 1XGOA 4U6WA 3PKBA 1WLRA 2BHDA 2BHAA 4U76A 5D6EA 2IW2A 1XNZA 2GG0A 2Q95A 2EVCA 1YW9A 3S6BA 1WKMA 1YVMA 2GU4A 3L7GA 2BWWA 3QOCA 3O5VA 4PNCA 4OOKA 3PN9A 4ZWOA 2BWYA 2V3ZA 2ZSGA 5D6FA 3RVAA 1QXYA 3PKDA
chains in the Genus database with same CATH topology
4PV4A 4S2TP 1CHMA 4U71A 4IDYA 3CB5A 1C23A 2BN7A 1MATA 4U70A 1YW8A 5CE6A 1W2MA 1WN1A 1C27A 1YW7A 2P9AA 1A16A 4FO8A 4U73A 4FLJA 2NQ7A 5CIKA 4ZNGA 1B59A 2GU5A 2DFIA 4MATA 2GA2A 3IU7A 4FLLA 5JHUA 4IKSA 2GG8A 3FMRA 1C24A 1PV9A 1XGSA 2MATA 2P98A 4FUKA 3CB6A 4U75A 2BWTA 2Q94A 1C21A 2B3HA 1R5GA 2P99A 1BOAA 4IECA 5E5BA 3IU9A 4IKUA 3IU8A 2HOWA 1YJ3A 2Q92A 3PEBA 4FLKA 4A6VA 4RZZA 4B28A 5CDVA 1KP0A 4ZWPA 2NQ6A 2Q93A 4U6EA 2GG3A 5FCHA 3L24A 3BITA 4A6WA 1B6AA 3I7MA 1QZYA 1BN5A 3BIPA 1WY2A 3FM3A 2EVMA 2OKNA 4S2RP 1XGNA 4EGEA 4FO7A 3MR1A 2Q8KA 4U69A 5CDEA 2BWUA 4IU6A 1WL6A 3IG4A 3OVKA 3PKAA 4JUQA 3OOOA 4U6JA 3TB5A 5JI6A 2BHBA 1R5HA 1KQ9A 4RZYA 2B3KA 1R58A 2OAZA 2V3XA 5FCFA 1N51A 5E2CA 2GZ5A 3PKCA 4ZWUA 2EA4A 4HXXA 3RORA 2Q96A 1XGMA 4U6CA 3BIQA 4FKCA 4IKRA 1WBQA 5CLSA 1O0XA 3Q6DA 4FLIA 5CDLA 2GGBA 2GU7A 3CTZA 4U6ZA 3TAVA 4S01A 2EA2A 1KQ0A 2GTXA 3MX6A 3MATA 2GG9A 3D27A 2V6CA 2BWSA 1QXZA 2B3LA 2GG7A 2GG5A 4IF7A 4IPAA 1M35A 1JAWA 2GG2A 1Y1NA 2BWVA 4R60A 1W7VA 2BB7A 4QR8A 3IL0A 1WL9A 1QXWA 2BHCA 5JFRA 2BH3A 4RGZ1 2GU6A 3FMQA 5CNXA 2V3YA 2BWXA 2G6PA 2ADUA 2EVOA 4Z7MA 3PKEA 4S00A 1C22A 4IKTA 2GGCA 4KM3A 4U1BA 1XGOA 4U6WA 3PKBA 1WLRA 2BHDA 2BHAA 4U76A 5D6EA 2IW2A 1XNZA 2GG0A 2Q95A 2EVCA 1YW9A 3S6BA 1WKMA 1YVMA 2GU4A 3L7GA 2BWWA 3QOCA 3O5VA 4PNCA 4OOKA 3PN9A 4ZWOA 2BWYA 2V3ZA 2ZSGA 5D6FA 3RVAA 1QXYA 3PKDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PV4 A;  4S2T P;  1CHM A;  4U71 A;  4IDY A;  3CB5 A;  1C23 A;  2BN7 A;  1MAT A;  4U70 A;  1YW8 A;  5CE6 A;  1W2M A;  1WN1 A;  1C27 A;  1YW7 A;  2P9A A;  1A16 A;  4FO8 A;  4U73 A;  4FLJ A;  2NQ7 A;  5CIK A;  4ZNG A;  1B59 A;  2GU5 A;  2DFI A;  4MAT A;  2GA2 A;  3IU7 A;  4FLL A;  5JHU A;  4IKS A;  2GG8 A;  3FMR A;  1C24 A;  1PV9 A;  1XGS A;  2MAT A;  2P98 A;  4FUK A;  3CB6 A;  4U75 A;  2BWT A;  2Q94 A;  1C21 A;  2B3H A;  1R5G A;  2P99 A;  1BOA A;  4IEC A;  5E5B A;  3IU9 A;  4IKU A;  3IU8 A;  2HOW A;  1YJ3 A;  2Q92 A;  3PEB A;  4FLK A;  4A6V A;  4RZZ A;  4B28 A;  5CDV A;  1KP0 A;  4ZWP A;  2NQ6 A;  2Q93 A;  4U6E A;  2GG3 A;  5FCH A;  3L24 A;  3BIT A;  4A6W A;  1B6A A;  3I7M A;  1QZY A;  1BN5 A;  3BIP A;  1WY2 A;  3FM3 A;  2EVM A;  2OKN A;  4S2R P;  1XGN A;  4EGE A;  4FO7 A;  3MR1 A;  2Q8K A;  4U69 A;  5CDE A;  2BWU A;  4IU6 A;  1WL6 A;  3IG4 A;  3OVK A;  3PKA A;  4JUQ A;  3OOO A;  4U6J A;  3TB5 A;  5JI6 A;  2BHB A;  1R5H A;  1KQ9 A;  4RZY A;  2B3K A;  1R58 A;  2OAZ A;  2V3X A;  5FCF A;  1N51 A;  5E2C A;  2GZ5 A;  3PKC A;  4ZWU A;  2EA4 A;  4HXX A;  3ROR A;  2Q96 A;  1XGM A;  4U6C A;  3BIQ A;  4FKC A;  4IKR A;  1WBQ A;  5CLS A;  1O0X A;  3Q6D A;  4FLI A;  5CDL A;  2GGB A;  2GU7 A;  3CTZ A;  4U6Z A;  3TAV A;  4S01 A;  2EA2 A;  1KQ0 A;  2GTX A;  3MX6 A;  3MAT A;  2GG9 A;  3D27 A;  2V6C A;  2BWS A;  1QXZ A;  2B3L A;  2GG7 A;  2GG5 A;  4IF7 A;  4IPA A;  1M35 A;  1JAW A;  2GG2 A;  1Y1N A;  2BWV A;  4R60 A;  1W7V A;  2BB7 A;  4QR8 A;  3IL0 A;  1WL9 A;  1QXW A;  2BHC A;  5JFR A;  2BH3 A;  4RGZ 1;  2GU6 A;  3FMQ A;  5CNX A;  2V3Y A;  2BWX A;  2G6P A;  2ADU A;  2EVO A;  4Z7M A;  3PKE A;  4S00 A;  1C22 A;  4IKT A;  2GGC A;  4KM3 A;  4U1B A;  1XGO A;  4U6W A;  3PKB A;  1WLR A;  2BHD A;  2BHA A;  4U76 A;  5D6E A;  2IW2 A;  1XNZ A;  2GG0 A;  2Q95 A;  2EVC A;  1YW9 A;  3S6B A;  1WKM A;  1YVM A;  2GU4 A;  3L7G A;  2BWW A;  3QOC A;  3O5V A;  4PNC A;  4OOK A;  3PN9 A;  4ZWO A;  2BWY A;  2V3Z A;  2ZSG A;  5D6F A;  3RVA A;  1QXY A;  3PKD A; 
#chains in the Genus database with same CATH topology
 4PV4 A;  4S2T P;  1CHM A;  4U71 A;  4IDY A;  3CB5 A;  1C23 A;  2BN7 A;  1MAT A;  4U70 A;  1YW8 A;  5CE6 A;  1W2M A;  1WN1 A;  1C27 A;  1YW7 A;  2P9A A;  1A16 A;  4FO8 A;  4U73 A;  4FLJ A;  2NQ7 A;  5CIK A;  4ZNG A;  1B59 A;  2GU5 A;  2DFI A;  4MAT A;  2GA2 A;  3IU7 A;  4FLL A;  5JHU A;  4IKS A;  2GG8 A;  3FMR A;  1C24 A;  1PV9 A;  1XGS A;  2MAT A;  2P98 A;  4FUK A;  3CB6 A;  4U75 A;  2BWT A;  2Q94 A;  1C21 A;  2B3H A;  1R5G A;  2P99 A;  1BOA A;  4IEC A;  5E5B A;  3IU9 A;  4IKU A;  3IU8 A;  2HOW A;  1YJ3 A;  2Q92 A;  3PEB A;  4FLK A;  4A6V A;  4RZZ A;  4B28 A;  5CDV A;  1KP0 A;  4ZWP A;  2NQ6 A;  2Q93 A;  4U6E A;  2GG3 A;  5FCH A;  3L24 A;  3BIT A;  4A6W A;  1B6A A;  3I7M A;  1QZY A;  1BN5 A;  3BIP A;  1WY2 A;  3FM3 A;  2EVM A;  2OKN A;  4S2R P;  1XGN A;  4EGE A;  4FO7 A;  3MR1 A;  2Q8K A;  4U69 A;  5CDE A;  2BWU A;  4IU6 A;  1WL6 A;  3IG4 A;  3OVK A;  3PKA A;  4JUQ A;  3OOO A;  4U6J A;  3TB5 A;  5JI6 A;  2BHB A;  1R5H A;  1KQ9 A;  4RZY A;  2B3K A;  1R58 A;  2OAZ A;  2V3X A;  5FCF A;  1N51 A;  5E2C A;  2GZ5 A;  3PKC A;  4ZWU A;  2EA4 A;  4HXX A;  3ROR A;  2Q96 A;  1XGM A;  4U6C A;  3BIQ A;  4FKC A;  4IKR A;  1WBQ A;  5CLS A;  1O0X A;  3Q6D A;  4FLI A;  5CDL A;  2GGB A;  2GU7 A;  3CTZ A;  4U6Z A;  3TAV A;  4S01 A;  2EA2 A;  1KQ0 A;  2GTX A;  3MX6 A;  3MAT A;  2GG9 A;  3D27 A;  2V6C A;  2BWS A;  1QXZ A;  2B3L A;  2GG7 A;  2GG5 A;  4IF7 A;  4IPA A;  1M35 A;  1JAW A;  2GG2 A;  1Y1N A;  2BWV A;  4R60 A;  1W7V A;  2BB7 A;  4QR8 A;  3IL0 A;  1WL9 A;  1QXW A;  2BHC A;  5JFR A;  2BH3 A;  4RGZ 1;  2GU6 A;  3FMQ A;  5CNX A;  2V3Y A;  2BWX A;  2G6P A;  2ADU A;  2EVO A;  4Z7M A;  3PKE A;  4S00 A;  1C22 A;  4IKT A;  2GGC A;  4KM3 A;  4U1B A;  1XGO A;  4U6W A;  3PKB A;  1WLR A;  2BHD A;  2BHA A;  4U76 A;  5D6E A;  2IW2 A;  1XNZ A;  2GG0 A;  2Q95 A;  2EVC A;  1YW9 A;  3S6B A;  1WKM A;  1YVM A;  2GU4 A;  3L7G A;  2BWW A;  3QOC A;  3O5V A;  4PNC A;  4OOK A;  3PN9 A;  4ZWO A;  2BWY A;  2V3Z A;  2ZSG A;  5D6F A;  3RVA A;  1QXY A;  3PKD A; 
#chains in the Genus database with same CATH homology
 4PV4 A;  4S2T P;  1CHM A;  4U71 A;  4IDY A;  3CB5 A;  1C23 A;  2BN7 A;  1MAT A;  4U70 A;  1YW8 A;  5CE6 A;  1W2M A;  1WN1 A;  1C27 A;  1YW7 A;  2P9A A;  1A16 A;  4FO8 A;  4U73 A;  4FLJ A;  2NQ7 A;  5CIK A;  4ZNG A;  1B59 A;  2GU5 A;  2DFI A;  4MAT A;  2GA2 A;  3IU7 A;  4FLL A;  5JHU A;  4IKS A;  2GG8 A;  3FMR A;  1C24 A;  1PV9 A;  1XGS A;  2MAT A;  2P98 A;  4FUK A;  3CB6 A;  4U75 A;  2BWT A;  2Q94 A;  1C21 A;  2B3H A;  1R5G A;  2P99 A;  1BOA A;  4IEC A;  5E5B A;  3IU9 A;  4IKU A;  3IU8 A;  2HOW A;  1YJ3 A;  2Q92 A;  3PEB A;  4FLK A;  4A6V A;  4RZZ A;  4B28 A;  5CDV A;  1KP0 A;  4ZWP A;  2NQ6 A;  2Q93 A;  4U6E A;  2GG3 A;  5FCH A;  3L24 A;  3BIT A;  4A6W A;  1B6A A;  3I7M A;  1QZY A;  1BN5 A;  3BIP A;  1WY2 A;  3FM3 A;  2EVM A;  2OKN A;  4S2R P;  1XGN A;  4EGE A;  4FO7 A;  3MR1 A;  2Q8K A;  4U69 A;  5CDE A;  2BWU A;  4IU6 A;  1WL6 A;  3IG4 A;  3OVK A;  3PKA A;  4JUQ A;  3OOO A;  4U6J A;  3TB5 A;  5JI6 A;  2BHB A;  1R5H A;  1KQ9 A;  4RZY A;  2B3K A;  1R58 A;  2OAZ A;  2V3X A;  5FCF A;  1N51 A;  5E2C A;  2GZ5 A;  3PKC A;  4ZWU A;  2EA4 A;  4HXX A;  3ROR A;  2Q96 A;  1XGM A;  4U6C A;  3BIQ A;  4FKC A;  4IKR A;  1WBQ A;  5CLS A;  1O0X A;  3Q6D A;  4FLI A;  5CDL A;  2GGB A;  2GU7 A;  3CTZ A;  4U6Z A;  3TAV A;  4S01 A;  2EA2 A;  1KQ0 A;  2GTX A;  3MX6 A;  3MAT A;  2GG9 A;  3D27 A;  2V6C A;  2BWS A;  1QXZ A;  2B3L A;  2GG7 A;  2GG5 A;  4IF7 A;  4IPA A;  1M35 A;  1JAW A;  2GG2 A;  1Y1N A;  2BWV A;  4R60 A;  1W7V A;  2BB7 A;  4QR8 A;  3IL0 A;  1WL9 A;  1QXW A;  2BHC A;  5JFR A;  2BH3 A;  4RGZ 1;  2GU6 A;  3FMQ A;  5CNX A;  2V3Y A;  2BWX A;  2G6P A;  2ADU A;  2EVO A;  4Z7M A;  3PKE A;  4S00 A;  1C22 A;  4IKT A;  2GGC A;  4KM3 A;  4U1B A;  1XGO A;  4U6W A;  3PKB A;  1WLR A;  2BHD A;  2BHA A;  4U76 A;  5D6E A;  2IW2 A;  1XNZ A;  2GG0 A;  2Q95 A;  2EVC A;  1YW9 A;  3S6B A;  1WKM A;  1YVM A;  2GU4 A;  3L7G A;  2BWW A;  3QOC A;  3O5V A;  4PNC A;  4OOK A;  3PN9 A;  4ZWO A;  2BWY A;  2V3Z A;  2ZSG A;  5D6F A;  3RVA A;  1QXY A;  3PKD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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