2IW2A

Crystal structure of human prolidase
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
477
structure length
477
Chain Sequence
GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of Human Prolidase: The Molecular Basis of Pd Disease
rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords XAA-PRO DIPEPTIDASE
total genus 170
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2006-06-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2iw2A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2iw2A02
2BHBA 3O5VA 4JUQA 4U76A 3OOOA 1A16A 5D6FA 3IU7A 4FO7A 3CTZA 3CB6A 1Y1NA 3RVAA 2DFIA 3PKAA 4IKSA 3TB5A 2GU5A 2GG2A 3D27A 2BWXA 1B6AA 1O0XA 2Q93A 2GU6A 4MATA 2BH3A 1KP0A 5CDVA 5CE6A 4OOKA 1JAWA 2B3HA 2P99A 4PNCA 4ZWUA 3TAVA 5E5BA 1QZYA 4IPAA 1XNZA 2GG0A 1WLRA 2Q8KA 1YJ3A 3RORA 2GU7A 4ZWOA 1WBQA 2Q96A 2ZSGA 3OVKA 1XGOA 3PKDA 4IKUA 4U6ZA 5CDLA 2BB7A 2Q95A 2GGBA 2V3YA 4QR8A 2B3KA 3IL0A 5FCHA 4U6CA 3PEBA 2BWTA 1W7VA 2P98A 1MATA 3QOCA 4U1BA 3BIQA 2MATA 1BN5A 3PKBA 4ZNGA 4RGZ1 1C23A 2ADUA 4KM3A 4U70A 1QXYA 4R60A 2HOWA 2NQ7A 4U71A 5JHUA 4FLJA 3L24A 3MR1A 1C27A 2BWVA 3MX6A 2G6PA 2GG3A 1KQ0A 1R5HA 2Q94A 4ZWPA 4RZYA 4FLKA 5JI6A 2GU4A 2EA4A 5E2CA 2BWWA 3MATA 3PN9A 4FUKA 1XGSA 1W2MA 5CNXA 3CB5A 2Q92A 2EVMA 3PKEA 2BHAA 2BWUA 1YW7A 1WY2A 4FO8A 2OKNA 4IDYA 4S01A 2BHDA 3Q6DA 2V3XA 2GGCA 1CHMA 4FLIA 2GG5A 3IU9A 2V6CA 3S6BA 1BOAA 5CLSA 1N51A 2GG7A 2IW2A 4Z7MA 3FMQA 1WL9A 1YW9A 4IECA 4IKTA 1PV9A 2BWYA 3I7MA 1WL6A 2BWSA 1XGNA 4IF7A 4U69A 5CDEA 2EVOA 1M35A 4RZZA 4EGEA 2V3ZA 1C24A 1R58A 2GG8A 4S2RP 5CIKA 2B3LA 3FM3A 1R5GA 2GTXA 3IU8A 4IKRA 4U75A 3IG4A 1C22A 2OAZA 4IU6A 1C21A 2GA2A 3PKCA 4PV4A 1B59A 4U6EA 3L7GA 1QXZA 4B28A 4HXXA 4FKCA 5JFRA 5FCFA 5D6EA 1KQ9A 2BHCA 2EA2A 3FMRA 2GZ5A 1QXWA 1YVMA 1YW8A 2BN7A 4FLLA 4A6WA 4U6JA 4S00A 2P9AA 3BITA 4S2TP 2GG9A 4A6VA 1WN1A 3BIPA 1WKMA 2EVCA 2NQ6A 4U6WA 1XGMA 4U73A
chains in the Genus database with same CATH superfamily
2BHBA 3O5VA 4JUQA 4U76A 3OOOA 1A16A 5D6FA 3IU7A 4FO7A 3CTZA 3CB6A 1Y1NA 3RVAA 2DFIA 3PKAA 4IKSA 3TB5A 2GU5A 2GG2A 3D27A 2BWXA 1B6AA 1O0XA 2Q93A 2GU6A 4MATA 2BH3A 1KP0A 5CDVA 5CE6A 4OOKA 1JAWA 2B3HA 2P99A 4PNCA 4ZWUA 3TAVA 5E5BA 1QZYA 4IPAA 1XNZA 2GG0A 1WLRA 2Q8KA 1YJ3A 3RORA 2GU7A 4ZWOA 1WBQA 2Q96A 2ZSGA 3OVKA 1XGOA 3PKDA 4IKUA 4U6ZA 5CDLA 2BB7A 2Q95A 2GGBA 2V3YA 4QR8A 2B3KA 3IL0A 5FCHA 4U6CA 3PEBA 2BWTA 1W7VA 2P98A 1MATA 3QOCA 4U1BA 3BIQA 2MATA 1BN5A 3PKBA 4ZNGA 4RGZ1 1C23A 2ADUA 4KM3A 4U70A 1QXYA 4R60A 2HOWA 2NQ7A 4U71A 5JHUA 4FLJA 3L24A 3MR1A 1C27A 2BWVA 3MX6A 2G6PA 2GG3A 1KQ0A 1R5HA 2Q94A 4ZWPA 4RZYA 4FLKA 5JI6A 2GU4A 2EA4A 5E2CA 2BWWA 3MATA 3PN9A 4FUKA 1XGSA 1W2MA 5CNXA 3CB5A 2Q92A 2EVMA 3PKEA 2BHAA 2BWUA 1YW7A 1WY2A 4FO8A 2OKNA 4IDYA 4S01A 2BHDA 3Q6DA 2V3XA 2GGCA 1CHMA 4FLIA 2GG5A 3IU9A 2V6CA 3S6BA 1BOAA 5CLSA 1N51A 2GG7A 2IW2A 4Z7MA 3FMQA 1WL9A 1YW9A 4IECA 4IKTA 1PV9A 2BWYA 3I7MA 1WL6A 2BWSA 1XGNA 4IF7A 4U69A 5CDEA 2EVOA 1M35A 4RZZA 4EGEA 2V3ZA 1C24A 1R58A 2GG8A 4S2RP 5CIKA 2B3LA 3FM3A 1R5GA 2GTXA 3IU8A 4IKRA 4U75A 3IG4A 1C22A 2OAZA 4IU6A 1C21A 2GA2A 3PKCA 4PV4A 1B59A 4U6EA 3L7GA 1QXZA 4B28A 4HXXA 4FKCA 5JFRA 5FCFA 5D6EA 1KQ9A 2BHCA 2EA2A 3FMRA 2GZ5A 1QXWA 1YVMA 1YW8A 2BN7A 4FLLA 4A6WA 4U6JA 4S00A 2P9AA 3BITA 4S2TP 2GG9A 4A6VA 1WN1A 3BIPA 1WKMA 2EVCA 2NQ6A 4U6WA 1XGMA 4U73A
chains in the Genus database with same CATH topology
2BHBA 3O5VA 4JUQA 4U76A 3OOOA 1A16A 5D6FA 3IU7A 4FO7A 3CTZA 3CB6A 1Y1NA 3RVAA 2DFIA 3PKAA 4IKSA 3TB5A 2GU5A 2GG2A 3D27A 2BWXA 1B6AA 1O0XA 2Q93A 2GU6A 4MATA 2BH3A 1KP0A 5CDVA 5CE6A 4OOKA 1JAWA 2B3HA 2P99A 4PNCA 4ZWUA 3TAVA 5E5BA 1QZYA 4IPAA 1XNZA 2GG0A 1WLRA 2Q8KA 1YJ3A 3RORA 2GU7A 4ZWOA 1WBQA 2Q96A 2ZSGA 3OVKA 1XGOA 3PKDA 4IKUA 4U6ZA 5CDLA 2BB7A 2Q95A 2GGBA 2V3YA 4QR8A 2B3KA 3IL0A 5FCHA 4U6CA 3PEBA 2BWTA 1W7VA 2P98A 1MATA 3QOCA 4U1BA 3BIQA 2MATA 1BN5A 3PKBA 4ZNGA 4RGZ1 1C23A 2ADUA 4KM3A 4U70A 1QXYA 4R60A 2HOWA 2NQ7A 4U71A 5JHUA 4FLJA 3L24A 3MR1A 1C27A 2BWVA 3MX6A 2G6PA 2GG3A 1KQ0A 1R5HA 2Q94A 4ZWPA 4RZYA 4FLKA 5JI6A 2GU4A 2EA4A 5E2CA 2BWWA 3MATA 3PN9A 4FUKA 1XGSA 1W2MA 5CNXA 3CB5A 2Q92A 2EVMA 3PKEA 2BHAA 2BWUA 1YW7A 1WY2A 4FO8A 2OKNA 4IDYA 4S01A 2BHDA 3Q6DA 2V3XA 2GGCA 1CHMA 4FLIA 2GG5A 3IU9A 2V6CA 3S6BA 1BOAA 5CLSA 1N51A 2GG7A 2IW2A 4Z7MA 3FMQA 1WL9A 1YW9A 4IECA 4IKTA 1PV9A 2BWYA 3I7MA 1WL6A 2BWSA 1XGNA 4IF7A 4U69A 5CDEA 2EVOA 1M35A 4RZZA 4EGEA 2V3ZA 1C24A 1R58A 2GG8A 4S2RP 5CIKA 2B3LA 3FM3A 1R5GA 2GTXA 3IU8A 4IKRA 4U75A 3IG4A 1C22A 2OAZA 4IU6A 1C21A 2GA2A 3PKCA 4PV4A 1B59A 4U6EA 3L7GA 1QXZA 4B28A 4HXXA 4FKCA 5JFRA 5FCFA 5D6EA 1KQ9A 2BHCA 2EA2A 3FMRA 2GZ5A 1QXWA 1YVMA 1YW8A 2BN7A 4FLLA 4A6WA 4U6JA 4S00A 2P9AA 3BITA 4S2TP 2GG9A 4A6VA 1WN1A 3BIPA 1WKMA 2EVCA 2NQ6A 4U6WA 1XGMA 4U73A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BHB A;  3O5V A;  4JUQ A;  4U76 A;  3OOO A;  1A16 A;  5D6F A;  3IU7 A;  4FO7 A;  3CTZ A;  3CB6 A;  1Y1N A;  3RVA A;  2DFI A;  3PKA A;  4IKS A;  3TB5 A;  2GU5 A;  2GG2 A;  3D27 A;  2BWX A;  1B6A A;  1O0X A;  2Q93 A;  2GU6 A;  4MAT A;  2BH3 A;  1KP0 A;  5CDV A;  5CE6 A;  4OOK A;  1JAW A;  2B3H A;  2P99 A;  4PNC A;  4ZWU A;  3TAV A;  5E5B A;  1QZY A;  4IPA A;  1XNZ A;  2GG0 A;  1WLR A;  2Q8K A;  1YJ3 A;  3ROR A;  2GU7 A;  4ZWO A;  1WBQ A;  2Q96 A;  2ZSG A;  3OVK A;  1XGO A;  3PKD A;  4IKU A;  4U6Z A;  5CDL A;  2BB7 A;  2Q95 A;  2GGB A;  2V3Y A;  4QR8 A;  2B3K A;  3IL0 A;  5FCH A;  4U6C A;  3PEB A;  2BWT A;  1W7V A;  2P98 A;  1MAT A;  3QOC A;  4U1B A;  3BIQ A;  2MAT A;  1BN5 A;  3PKB A;  4ZNG A;  4RGZ 1;  1C23 A;  2ADU A;  4KM3 A;  4U70 A;  1QXY A;  4R60 A;  2HOW A;  2NQ7 A;  4U71 A;  5JHU A;  4FLJ A;  3L24 A;  3MR1 A;  1C27 A;  2BWV A;  3MX6 A;  2G6P A;  2GG3 A;  1KQ0 A;  1R5H A;  2Q94 A;  4ZWP A;  4RZY A;  4FLK A;  5JI6 A;  2GU4 A;  2EA4 A;  5E2C A;  2BWW A;  3MAT A;  3PN9 A;  4FUK A;  1XGS A;  1W2M A;  5CNX A;  3CB5 A;  2Q92 A;  2EVM A;  3PKE A;  2BHA A;  2BWU A;  1YW7 A;  1WY2 A;  4FO8 A;  2OKN A;  4IDY A;  4S01 A;  2BHD A;  3Q6D A;  2V3X A;  2GGC A;  1CHM A;  4FLI A;  2GG5 A;  3IU9 A;  2V6C A;  3S6B A;  1BOA A;  5CLS A;  1N51 A;  2GG7 A;  2IW2 A;  4Z7M A;  3FMQ A;  1WL9 A;  1YW9 A;  4IEC A;  4IKT A;  1PV9 A;  2BWY A;  3I7M A;  1WL6 A;  2BWS A;  1XGN A;  4IF7 A;  4U69 A;  5CDE A;  2EVO A;  1M35 A;  4RZZ A;  4EGE A;  2V3Z A;  1C24 A;  1R58 A;  2GG8 A;  4S2R P;  5CIK A;  2B3L A;  3FM3 A;  1R5G A;  2GTX A;  3IU8 A;  4IKR A;  4U75 A;  3IG4 A;  1C22 A;  2OAZ A;  4IU6 A;  1C21 A;  2GA2 A;  3PKC A;  4PV4 A;  1B59 A;  4U6E A;  3L7G A;  1QXZ A;  4B28 A;  4HXX A;  4FKC A;  5JFR A;  5FCF A;  5D6E A;  1KQ9 A;  2BHC A;  2EA2 A;  3FMR A;  2GZ5 A;  1QXW A;  1YVM A;  1YW8 A;  2BN7 A;  4FLL A;  4A6W A;  4U6J A;  4S00 A;  2P9A A;  3BIT A;  4S2T P;  2GG9 A;  4A6V A;  1WN1 A;  3BIP A;  1WKM A;  2EVC A;  2NQ6 A;  4U6W A;  1XGM A;  4U73 A; 
#chains in the Genus database with same CATH topology
 2BHB A;  3O5V A;  4JUQ A;  4U76 A;  3OOO A;  1A16 A;  5D6F A;  3IU7 A;  4FO7 A;  3CTZ A;  3CB6 A;  1Y1N A;  3RVA A;  2DFI A;  3PKA A;  4IKS A;  3TB5 A;  2GU5 A;  2GG2 A;  3D27 A;  2BWX A;  1B6A A;  1O0X A;  2Q93 A;  2GU6 A;  4MAT A;  2BH3 A;  1KP0 A;  5CDV A;  5CE6 A;  4OOK A;  1JAW A;  2B3H A;  2P99 A;  4PNC A;  4ZWU A;  3TAV A;  5E5B A;  1QZY A;  4IPA A;  1XNZ A;  2GG0 A;  1WLR A;  2Q8K A;  1YJ3 A;  3ROR A;  2GU7 A;  4ZWO A;  1WBQ A;  2Q96 A;  2ZSG A;  3OVK A;  1XGO A;  3PKD A;  4IKU A;  4U6Z A;  5CDL A;  2BB7 A;  2Q95 A;  2GGB A;  2V3Y A;  4QR8 A;  2B3K A;  3IL0 A;  5FCH A;  4U6C A;  3PEB A;  2BWT A;  1W7V A;  2P98 A;  1MAT A;  3QOC A;  4U1B A;  3BIQ A;  2MAT A;  1BN5 A;  3PKB A;  4ZNG A;  4RGZ 1;  1C23 A;  2ADU A;  4KM3 A;  4U70 A;  1QXY A;  4R60 A;  2HOW A;  2NQ7 A;  4U71 A;  5JHU A;  4FLJ A;  3L24 A;  3MR1 A;  1C27 A;  2BWV A;  3MX6 A;  2G6P A;  2GG3 A;  1KQ0 A;  1R5H A;  2Q94 A;  4ZWP A;  4RZY A;  4FLK A;  5JI6 A;  2GU4 A;  2EA4 A;  5E2C A;  2BWW A;  3MAT A;  3PN9 A;  4FUK A;  1XGS A;  1W2M A;  5CNX A;  3CB5 A;  2Q92 A;  2EVM A;  3PKE A;  2BHA A;  2BWU A;  1YW7 A;  1WY2 A;  4FO8 A;  2OKN A;  4IDY A;  4S01 A;  2BHD A;  3Q6D A;  2V3X A;  2GGC A;  1CHM A;  4FLI A;  2GG5 A;  3IU9 A;  2V6C A;  3S6B A;  1BOA A;  5CLS A;  1N51 A;  2GG7 A;  2IW2 A;  4Z7M A;  3FMQ A;  1WL9 A;  1YW9 A;  4IEC A;  4IKT A;  1PV9 A;  2BWY A;  3I7M A;  1WL6 A;  2BWS A;  1XGN A;  4IF7 A;  4U69 A;  5CDE A;  2EVO A;  1M35 A;  4RZZ A;  4EGE A;  2V3Z A;  1C24 A;  1R58 A;  2GG8 A;  4S2R P;  5CIK A;  2B3L A;  3FM3 A;  1R5G A;  2GTX A;  3IU8 A;  4IKR A;  4U75 A;  3IG4 A;  1C22 A;  2OAZ A;  4IU6 A;  1C21 A;  2GA2 A;  3PKC A;  4PV4 A;  1B59 A;  4U6E A;  3L7G A;  1QXZ A;  4B28 A;  4HXX A;  4FKC A;  5JFR A;  5FCF A;  5D6E A;  1KQ9 A;  2BHC A;  2EA2 A;  3FMR A;  2GZ5 A;  1QXW A;  1YVM A;  1YW8 A;  2BN7 A;  4FLL A;  4A6W A;  4U6J A;  4S00 A;  2P9A A;  3BIT A;  4S2T P;  2GG9 A;  4A6V A;  1WN1 A;  3BIP A;  1WKM A;  2EVC A;  2NQ6 A;  4U6W A;  1XGM A;  4U73 A; 
#chains in the Genus database with same CATH homology
 2BHB A;  3O5V A;  4JUQ A;  4U76 A;  3OOO A;  1A16 A;  5D6F A;  3IU7 A;  4FO7 A;  3CTZ A;  3CB6 A;  1Y1N A;  3RVA A;  2DFI A;  3PKA A;  4IKS A;  3TB5 A;  2GU5 A;  2GG2 A;  3D27 A;  2BWX A;  1B6A A;  1O0X A;  2Q93 A;  2GU6 A;  4MAT A;  2BH3 A;  1KP0 A;  5CDV A;  5CE6 A;  4OOK A;  1JAW A;  2B3H A;  2P99 A;  4PNC A;  4ZWU A;  3TAV A;  5E5B A;  1QZY A;  4IPA A;  1XNZ A;  2GG0 A;  1WLR A;  2Q8K A;  1YJ3 A;  3ROR A;  2GU7 A;  4ZWO A;  1WBQ A;  2Q96 A;  2ZSG A;  3OVK A;  1XGO A;  3PKD A;  4IKU A;  4U6Z A;  5CDL A;  2BB7 A;  2Q95 A;  2GGB A;  2V3Y A;  4QR8 A;  2B3K A;  3IL0 A;  5FCH A;  4U6C A;  3PEB A;  2BWT A;  1W7V A;  2P98 A;  1MAT A;  3QOC A;  4U1B A;  3BIQ A;  2MAT A;  1BN5 A;  3PKB A;  4ZNG A;  4RGZ 1;  1C23 A;  2ADU A;  4KM3 A;  4U70 A;  1QXY A;  4R60 A;  2HOW A;  2NQ7 A;  4U71 A;  5JHU A;  4FLJ A;  3L24 A;  3MR1 A;  1C27 A;  2BWV A;  3MX6 A;  2G6P A;  2GG3 A;  1KQ0 A;  1R5H A;  2Q94 A;  4ZWP A;  4RZY A;  4FLK A;  5JI6 A;  2GU4 A;  2EA4 A;  5E2C A;  2BWW A;  3MAT A;  3PN9 A;  4FUK A;  1XGS A;  1W2M A;  5CNX A;  3CB5 A;  2Q92 A;  2EVM A;  3PKE A;  2BHA A;  2BWU A;  1YW7 A;  1WY2 A;  4FO8 A;  2OKN A;  4IDY A;  4S01 A;  2BHD A;  3Q6D A;  2V3X A;  2GGC A;  1CHM A;  4FLI A;  2GG5 A;  3IU9 A;  2V6C A;  3S6B A;  1BOA A;  5CLS A;  1N51 A;  2GG7 A;  2IW2 A;  4Z7M A;  3FMQ A;  1WL9 A;  1YW9 A;  4IEC A;  4IKT A;  1PV9 A;  2BWY A;  3I7M A;  1WL6 A;  2BWS A;  1XGN A;  4IF7 A;  4U69 A;  5CDE A;  2EVO A;  1M35 A;  4RZZ A;  4EGE A;  2V3Z A;  1C24 A;  1R58 A;  2GG8 A;  4S2R P;  5CIK A;  2B3L A;  3FM3 A;  1R5G A;  2GTX A;  3IU8 A;  4IKR A;  4U75 A;  3IG4 A;  1C22 A;  2OAZ A;  4IU6 A;  1C21 A;  2GA2 A;  3PKC A;  4PV4 A;  1B59 A;  4U6E A;  3L7G A;  1QXZ A;  4B28 A;  4HXX A;  4FKC A;  5JFR A;  5FCF A;  5D6E A;  1KQ9 A;  2BHC A;  2EA2 A;  3FMR A;  2GZ5 A;  1QXW A;  1YVM A;  1YW8 A;  2BN7 A;  4FLL A;  4A6W A;  4U6J A;  4S00 A;  2P9A A;  3BIT A;  4S2T P;  2GG9 A;  4A6V A;  1WN1 A;  3BIP A;  1WKM A;  2EVC A;  2NQ6 A;  4U6W A;  1XGM A;  4U73 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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