2IW2A

Crystal structure of human prolidase
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
477
structure length
477
Chain Sequence
GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of Human Prolidase: The Molecular Basis of Pd Disease
rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords XAA-PRO DIPEPTIDASE
total genus 170
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2006-06-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2iw2A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2iw2A02
4FO7A 2BHDA 4U6EA 2BB7A 2BWXA 1XGOA 2B3HA 2GGBA 1XGMA 3FMRA 2Q94A 2GU7A 3MR1A 3FM3A 3BIQA 4IKUA 1XGNA 2MATA 4R60A 3MX6A 2BWSA 3O5VA 1YW9A 4PNCA 2ADUA 2Q8KA 3RORA 1WLRA 2EVOA 1QXYA 3I7MA 3IL0A 4RZZA 3OVKA 4U71A 2EVMA 3Q6DA 1WKMA 1R5HA 4U69A 2GG8A 4S2TP 4EGEA 1WL9A 4U70A 5D6EA 1BN5A 1C27A 3IU8A 2Q93A 3TAVA 3S6BA 1PV9A 2BHAA 1N51A 4S2RP 4U1BA 1QXWA 3RVAA 2EA4A 2ZSGA 2OKNA 5CLSA 2Q96A 3IG4A 2GGCA 1R5GA 1WN1A 2V3YA 3TB5A 2BN7A 2BWWA 4B28A 2GU4A 5JHUA 2GG0A 3CTZA 4IPAA 1WBQA 4S01A 3CB5A 4JUQA 1W7VA 2GTXA 4QR8A 2NQ7A 2Q92A 2BWYA 4ZWUA 2Q95A 4FLKA 4FLIA 5CDVA 4IKTA 4ZWOA 5CDLA 1Y1NA 1B59A 2G6PA 1BOAA 4S00A 1YW7A 3CB6A 1WY2A 4FKCA 5FCFA 2DFIA 2GU6A 4U76A 5JFRA 4U6ZA 1KQ0A 3PKBA 2BWUA 3PEBA 4RZYA 1WL6A 4U6CA 4U6JA 4FO8A 3PKCA 2BHBA 2GA2A 5CNXA 2BH3A 1CHMA 1C22A 4A6WA 3QOCA 3D27A 1C23A 4U75A 2B3LA 3BITA 2V3XA 2V6CA 4KM3A 2BWVA 5E2CA 1C24A 1YW8A 4FUKA 4IU6A 2V3ZA 1QXZA 4U6WA 1XGSA 1XNZA 2GG2A 2B3KA 2NQ6A 2P9AA 5CE6A 3FMQA 2GG7A 3PKEA 1M35A 2GG5A 4Z7MA 1R58A 5JI6A 1MATA 1YVMA 3PKDA 1JAWA 3OOOA 2GU5A 3IU7A 5FCHA 2GG9A 2HOWA 3BIPA 2GG3A 3L7GA 5CDEA 4HXXA 4U73A 4IF7A 2GZ5A 3MATA 2EA2A 1QZYA 2EVCA 2IW2A 1C21A 5CIKA 1YJ3A 2P98A 1KQ9A 4IDYA 2BHCA 2BWTA 4OOKA 4IKSA 1A16A 3L24A 4IKRA 3IU9A 3PN9A 4RGZ1 4ZNGA 4MATA 2OAZA 1O0XA 1W2MA 2P99A 4ZWPA 4IECA 3PKAA 5D6FA 4FLJA 4FLLA 5E5BA 4A6VA 1KP0A 1B6AA 4PV4A
chains in the Genus database with same CATH superfamily
4FO7A 2BHDA 4U6EA 2BB7A 2BWXA 1XGOA 2B3HA 2GGBA 1XGMA 3FMRA 2Q94A 2GU7A 3MR1A 3FM3A 3BIQA 4IKUA 1XGNA 2MATA 4R60A 3MX6A 2BWSA 3O5VA 1YW9A 4PNCA 2ADUA 2Q8KA 3RORA 1WLRA 2EVOA 1QXYA 3I7MA 3IL0A 4RZZA 3OVKA 4U71A 2EVMA 3Q6DA 1WKMA 1R5HA 4U69A 2GG8A 4S2TP 4EGEA 1WL9A 4U70A 5D6EA 1BN5A 1C27A 3IU8A 2Q93A 3TAVA 3S6BA 1PV9A 2BHAA 1N51A 4S2RP 4U1BA 1QXWA 3RVAA 2EA4A 2ZSGA 2OKNA 5CLSA 2Q96A 3IG4A 2GGCA 1R5GA 1WN1A 2V3YA 3TB5A 2BN7A 2BWWA 4B28A 2GU4A 5JHUA 2GG0A 3CTZA 4IPAA 1WBQA 4S01A 3CB5A 4JUQA 1W7VA 2GTXA 4QR8A 2NQ7A 2Q92A 2BWYA 4ZWUA 2Q95A 4FLKA 4FLIA 5CDVA 4IKTA 4ZWOA 5CDLA 1Y1NA 1B59A 2G6PA 1BOAA 4S00A 1YW7A 3CB6A 1WY2A 4FKCA 5FCFA 2DFIA 2GU6A 4U76A 5JFRA 4U6ZA 1KQ0A 3PKBA 2BWUA 3PEBA 4RZYA 1WL6A 4U6CA 4U6JA 4FO8A 3PKCA 2BHBA 2GA2A 5CNXA 2BH3A 1CHMA 1C22A 4A6WA 3QOCA 3D27A 1C23A 4U75A 2B3LA 3BITA 2V3XA 2V6CA 4KM3A 2BWVA 5E2CA 1C24A 1YW8A 4FUKA 4IU6A 2V3ZA 1QXZA 4U6WA 1XGSA 1XNZA 2GG2A 2B3KA 2NQ6A 2P9AA 5CE6A 3FMQA 2GG7A 3PKEA 1M35A 2GG5A 4Z7MA 1R58A 5JI6A 1MATA 1YVMA 3PKDA 1JAWA 3OOOA 2GU5A 3IU7A 5FCHA 2GG9A 2HOWA 3BIPA 2GG3A 3L7GA 5CDEA 4HXXA 4U73A 4IF7A 2GZ5A 3MATA 2EA2A 1QZYA 2EVCA 2IW2A 1C21A 5CIKA 1YJ3A 2P98A 1KQ9A 4IDYA 2BHCA 2BWTA 4OOKA 4IKSA 1A16A 3L24A 4IKRA 3IU9A 3PN9A 4RGZ1 4ZNGA 4MATA 2OAZA 1O0XA 1W2MA 2P99A 4ZWPA 4IECA 3PKAA 5D6FA 4FLJA 4FLLA 5E5BA 4A6VA 1KP0A 1B6AA 4PV4A
chains in the Genus database with same CATH topology
4FO7A 2BHDA 4U6EA 2BB7A 2BWXA 1XGOA 2B3HA 2GGBA 1XGMA 3FMRA 2Q94A 2GU7A 3MR1A 3FM3A 3BIQA 4IKUA 1XGNA 2MATA 4R60A 3MX6A 2BWSA 3O5VA 1YW9A 4PNCA 2ADUA 2Q8KA 3RORA 1WLRA 2EVOA 1QXYA 3I7MA 3IL0A 4RZZA 3OVKA 4U71A 2EVMA 3Q6DA 1WKMA 1R5HA 4U69A 2GG8A 4S2TP 4EGEA 1WL9A 4U70A 5D6EA 1BN5A 1C27A 3IU8A 2Q93A 3TAVA 3S6BA 1PV9A 2BHAA 1N51A 4S2RP 4U1BA 1QXWA 3RVAA 2EA4A 2ZSGA 2OKNA 5CLSA 2Q96A 3IG4A 2GGCA 1R5GA 1WN1A 2V3YA 3TB5A 2BN7A 2BWWA 4B28A 2GU4A 5JHUA 2GG0A 3CTZA 4IPAA 1WBQA 4S01A 3CB5A 4JUQA 1W7VA 2GTXA 4QR8A 2NQ7A 2Q92A 2BWYA 4ZWUA 2Q95A 4FLKA 4FLIA 5CDVA 4IKTA 4ZWOA 5CDLA 1Y1NA 1B59A 2G6PA 1BOAA 4S00A 1YW7A 3CB6A 1WY2A 4FKCA 5FCFA 2DFIA 2GU6A 4U76A 5JFRA 4U6ZA 1KQ0A 3PKBA 2BWUA 3PEBA 4RZYA 1WL6A 4U6CA 4U6JA 4FO8A 3PKCA 2BHBA 2GA2A 5CNXA 2BH3A 1CHMA 1C22A 4A6WA 3QOCA 3D27A 1C23A 4U75A 2B3LA 3BITA 2V3XA 2V6CA 4KM3A 2BWVA 5E2CA 1C24A 1YW8A 4FUKA 4IU6A 2V3ZA 1QXZA 4U6WA 1XGSA 1XNZA 2GG2A 2B3KA 2NQ6A 2P9AA 5CE6A 3FMQA 2GG7A 3PKEA 1M35A 2GG5A 4Z7MA 1R58A 5JI6A 1MATA 1YVMA 3PKDA 1JAWA 3OOOA 2GU5A 3IU7A 5FCHA 2GG9A 2HOWA 3BIPA 2GG3A 3L7GA 5CDEA 4HXXA 4U73A 4IF7A 2GZ5A 3MATA 2EA2A 1QZYA 2EVCA 2IW2A 1C21A 5CIKA 1YJ3A 2P98A 1KQ9A 4IDYA 2BHCA 2BWTA 4OOKA 4IKSA 1A16A 3L24A 4IKRA 3IU9A 3PN9A 4RGZ1 4ZNGA 4MATA 2OAZA 1O0XA 1W2MA 2P99A 4ZWPA 4IECA 3PKAA 5D6FA 4FLJA 4FLLA 5E5BA 4A6VA 1KP0A 1B6AA 4PV4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FO7 A;  2BHD A;  4U6E A;  2BB7 A;  2BWX A;  1XGO A;  2B3H A;  2GGB A;  1XGM A;  3FMR A;  2Q94 A;  2GU7 A;  3MR1 A;  3FM3 A;  3BIQ A;  4IKU A;  1XGN A;  2MAT A;  4R60 A;  3MX6 A;  2BWS A;  3O5V A;  1YW9 A;  4PNC A;  2ADU A;  2Q8K A;  3ROR A;  1WLR A;  2EVO A;  1QXY A;  3I7M A;  3IL0 A;  4RZZ A;  3OVK A;  4U71 A;  2EVM A;  3Q6D A;  1WKM A;  1R5H A;  4U69 A;  2GG8 A;  4S2T P;  4EGE A;  1WL9 A;  4U70 A;  5D6E A;  1BN5 A;  1C27 A;  3IU8 A;  2Q93 A;  3TAV A;  3S6B A;  1PV9 A;  2BHA A;  1N51 A;  4S2R P;  4U1B A;  1QXW A;  3RVA A;  2EA4 A;  2ZSG A;  2OKN A;  5CLS A;  2Q96 A;  3IG4 A;  2GGC A;  1R5G A;  1WN1 A;  2V3Y A;  3TB5 A;  2BN7 A;  2BWW A;  4B28 A;  2GU4 A;  5JHU A;  2GG0 A;  3CTZ A;  4IPA A;  1WBQ A;  4S01 A;  3CB5 A;  4JUQ A;  1W7V A;  2GTX A;  4QR8 A;  2NQ7 A;  2Q92 A;  2BWY A;  4ZWU A;  2Q95 A;  4FLK A;  4FLI A;  5CDV A;  4IKT A;  4ZWO A;  5CDL A;  1Y1N A;  1B59 A;  2G6P A;  1BOA A;  4S00 A;  1YW7 A;  3CB6 A;  1WY2 A;  4FKC A;  5FCF A;  2DFI A;  2GU6 A;  4U76 A;  5JFR A;  4U6Z A;  1KQ0 A;  3PKB A;  2BWU A;  3PEB A;  4RZY A;  1WL6 A;  4U6C A;  4U6J A;  4FO8 A;  3PKC A;  2BHB A;  2GA2 A;  5CNX A;  2BH3 A;  1CHM A;  1C22 A;  4A6W A;  3QOC A;  3D27 A;  1C23 A;  4U75 A;  2B3L A;  3BIT A;  2V3X A;  2V6C A;  4KM3 A;  2BWV A;  5E2C A;  1C24 A;  1YW8 A;  4FUK A;  4IU6 A;  2V3Z A;  1QXZ A;  4U6W A;  1XGS A;  1XNZ A;  2GG2 A;  2B3K A;  2NQ6 A;  2P9A A;  5CE6 A;  3FMQ A;  2GG7 A;  3PKE A;  1M35 A;  2GG5 A;  4Z7M A;  1R58 A;  5JI6 A;  1MAT A;  1YVM A;  3PKD A;  1JAW A;  3OOO A;  2GU5 A;  3IU7 A;  5FCH A;  2GG9 A;  2HOW A;  3BIP A;  2GG3 A;  3L7G A;  5CDE A;  4HXX A;  4U73 A;  4IF7 A;  2GZ5 A;  3MAT A;  2EA2 A;  1QZY A;  2EVC A;  2IW2 A;  1C21 A;  5CIK A;  1YJ3 A;  2P98 A;  1KQ9 A;  4IDY A;  2BHC A;  2BWT A;  4OOK A;  4IKS A;  1A16 A;  3L24 A;  4IKR A;  3IU9 A;  3PN9 A;  4RGZ 1;  4ZNG A;  4MAT A;  2OAZ A;  1O0X A;  1W2M A;  2P99 A;  4ZWP A;  4IEC A;  3PKA A;  5D6F A;  4FLJ A;  4FLL A;  5E5B A;  4A6V A;  1KP0 A;  1B6A A;  4PV4 A; 
#chains in the Genus database with same CATH topology
 4FO7 A;  2BHD A;  4U6E A;  2BB7 A;  2BWX A;  1XGO A;  2B3H A;  2GGB A;  1XGM A;  3FMR A;  2Q94 A;  2GU7 A;  3MR1 A;  3FM3 A;  3BIQ A;  4IKU A;  1XGN A;  2MAT A;  4R60 A;  3MX6 A;  2BWS A;  3O5V A;  1YW9 A;  4PNC A;  2ADU A;  2Q8K A;  3ROR A;  1WLR A;  2EVO A;  1QXY A;  3I7M A;  3IL0 A;  4RZZ A;  3OVK A;  4U71 A;  2EVM A;  3Q6D A;  1WKM A;  1R5H A;  4U69 A;  2GG8 A;  4S2T P;  4EGE A;  1WL9 A;  4U70 A;  5D6E A;  1BN5 A;  1C27 A;  3IU8 A;  2Q93 A;  3TAV A;  3S6B A;  1PV9 A;  2BHA A;  1N51 A;  4S2R P;  4U1B A;  1QXW A;  3RVA A;  2EA4 A;  2ZSG A;  2OKN A;  5CLS A;  2Q96 A;  3IG4 A;  2GGC A;  1R5G A;  1WN1 A;  2V3Y A;  3TB5 A;  2BN7 A;  2BWW A;  4B28 A;  2GU4 A;  5JHU A;  2GG0 A;  3CTZ A;  4IPA A;  1WBQ A;  4S01 A;  3CB5 A;  4JUQ A;  1W7V A;  2GTX A;  4QR8 A;  2NQ7 A;  2Q92 A;  2BWY A;  4ZWU A;  2Q95 A;  4FLK A;  4FLI A;  5CDV A;  4IKT A;  4ZWO A;  5CDL A;  1Y1N A;  1B59 A;  2G6P A;  1BOA A;  4S00 A;  1YW7 A;  3CB6 A;  1WY2 A;  4FKC A;  5FCF A;  2DFI A;  2GU6 A;  4U76 A;  5JFR A;  4U6Z A;  1KQ0 A;  3PKB A;  2BWU A;  3PEB A;  4RZY A;  1WL6 A;  4U6C A;  4U6J A;  4FO8 A;  3PKC A;  2BHB A;  2GA2 A;  5CNX A;  2BH3 A;  1CHM A;  1C22 A;  4A6W A;  3QOC A;  3D27 A;  1C23 A;  4U75 A;  2B3L A;  3BIT A;  2V3X A;  2V6C A;  4KM3 A;  2BWV A;  5E2C A;  1C24 A;  1YW8 A;  4FUK A;  4IU6 A;  2V3Z A;  1QXZ A;  4U6W A;  1XGS A;  1XNZ A;  2GG2 A;  2B3K A;  2NQ6 A;  2P9A A;  5CE6 A;  3FMQ A;  2GG7 A;  3PKE A;  1M35 A;  2GG5 A;  4Z7M A;  1R58 A;  5JI6 A;  1MAT A;  1YVM A;  3PKD A;  1JAW A;  3OOO A;  2GU5 A;  3IU7 A;  5FCH A;  2GG9 A;  2HOW A;  3BIP A;  2GG3 A;  3L7G A;  5CDE A;  4HXX A;  4U73 A;  4IF7 A;  2GZ5 A;  3MAT A;  2EA2 A;  1QZY A;  2EVC A;  2IW2 A;  1C21 A;  5CIK A;  1YJ3 A;  2P98 A;  1KQ9 A;  4IDY A;  2BHC A;  2BWT A;  4OOK A;  4IKS A;  1A16 A;  3L24 A;  4IKR A;  3IU9 A;  3PN9 A;  4RGZ 1;  4ZNG A;  4MAT A;  2OAZ A;  1O0X A;  1W2M A;  2P99 A;  4ZWP A;  4IEC A;  3PKA A;  5D6F A;  4FLJ A;  4FLL A;  5E5B A;  4A6V A;  1KP0 A;  1B6A A;  4PV4 A; 
#chains in the Genus database with same CATH homology
 4FO7 A;  2BHD A;  4U6E A;  2BB7 A;  2BWX A;  1XGO A;  2B3H A;  2GGB A;  1XGM A;  3FMR A;  2Q94 A;  2GU7 A;  3MR1 A;  3FM3 A;  3BIQ A;  4IKU A;  1XGN A;  2MAT A;  4R60 A;  3MX6 A;  2BWS A;  3O5V A;  1YW9 A;  4PNC A;  2ADU A;  2Q8K A;  3ROR A;  1WLR A;  2EVO A;  1QXY A;  3I7M A;  3IL0 A;  4RZZ A;  3OVK A;  4U71 A;  2EVM A;  3Q6D A;  1WKM A;  1R5H A;  4U69 A;  2GG8 A;  4S2T P;  4EGE A;  1WL9 A;  4U70 A;  5D6E A;  1BN5 A;  1C27 A;  3IU8 A;  2Q93 A;  3TAV A;  3S6B A;  1PV9 A;  2BHA A;  1N51 A;  4S2R P;  4U1B A;  1QXW A;  3RVA A;  2EA4 A;  2ZSG A;  2OKN A;  5CLS A;  2Q96 A;  3IG4 A;  2GGC A;  1R5G A;  1WN1 A;  2V3Y A;  3TB5 A;  2BN7 A;  2BWW A;  4B28 A;  2GU4 A;  5JHU A;  2GG0 A;  3CTZ A;  4IPA A;  1WBQ A;  4S01 A;  3CB5 A;  4JUQ A;  1W7V A;  2GTX A;  4QR8 A;  2NQ7 A;  2Q92 A;  2BWY A;  4ZWU A;  2Q95 A;  4FLK A;  4FLI A;  5CDV A;  4IKT A;  4ZWO A;  5CDL A;  1Y1N A;  1B59 A;  2G6P A;  1BOA A;  4S00 A;  1YW7 A;  3CB6 A;  1WY2 A;  4FKC A;  5FCF A;  2DFI A;  2GU6 A;  4U76 A;  5JFR A;  4U6Z A;  1KQ0 A;  3PKB A;  2BWU A;  3PEB A;  4RZY A;  1WL6 A;  4U6C A;  4U6J A;  4FO8 A;  3PKC A;  2BHB A;  2GA2 A;  5CNX A;  2BH3 A;  1CHM A;  1C22 A;  4A6W A;  3QOC A;  3D27 A;  1C23 A;  4U75 A;  2B3L A;  3BIT A;  2V3X A;  2V6C A;  4KM3 A;  2BWV A;  5E2C A;  1C24 A;  1YW8 A;  4FUK A;  4IU6 A;  2V3Z A;  1QXZ A;  4U6W A;  1XGS A;  1XNZ A;  2GG2 A;  2B3K A;  2NQ6 A;  2P9A A;  5CE6 A;  3FMQ A;  2GG7 A;  3PKE A;  1M35 A;  2GG5 A;  4Z7M A;  1R58 A;  5JI6 A;  1MAT A;  1YVM A;  3PKD A;  1JAW A;  3OOO A;  2GU5 A;  3IU7 A;  5FCH A;  2GG9 A;  2HOW A;  3BIP A;  2GG3 A;  3L7G A;  5CDE A;  4HXX A;  4U73 A;  4IF7 A;  2GZ5 A;  3MAT A;  2EA2 A;  1QZY A;  2EVC A;  2IW2 A;  1C21 A;  5CIK A;  1YJ3 A;  2P98 A;  1KQ9 A;  4IDY A;  2BHC A;  2BWT A;  4OOK A;  4IKS A;  1A16 A;  3L24 A;  4IKR A;  3IU9 A;  3PN9 A;  4RGZ 1;  4ZNG A;  4MAT A;  2OAZ A;  1O0X A;  1W2M A;  2P99 A;  4ZWP A;  4IEC A;  3PKA A;  5D6F A;  4FLJ A;  4FLL A;  5E5B A;  4A6V A;  1KP0 A;  1B6A A;  4PV4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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