2IW2A

Crystal structure of human prolidase
Total Genus 170
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
477
structure length
477
Chain Sequence
GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords XAA-PRO DIPEPTIDASE
publication title Crystal Structure of Human Prolidase: The Molecular Basis of Pd Disease
rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 170
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2006-06-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2iw2A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2iw2A02
2GGCA 2Q94A 3PKCA 2BWTA 1WL6A 1B59A 4IF7A 1WLRA 4ZWPA 3PKBA 1A16A 5CIKA 4MATA 3PKAA 1W7VA 4IKSA 4IKRA 2BHAA 2BWUA 2B3KA 3OOOA 4ZNGA 1YVMA 3PKDA 2IW2A 1QXZA 2GU4A 4HXXA 2GG9A 2GG7A 2BHBA 4PNCA 2GA2A 1R58A 5E5BA 1R5HA 1R5GA 3IL0A 2DFIA 4IPAA 3TB5A 1PV9A 3L7GA 5FCHA 1BN5A 1XGMA 2BHDA 1YW9A 4FO8A 4U73A 5JI6A 1QXYA 1Y1NA 4IU6A 2BWXA 1M35A 2GG3A 2Q8KA 1WKMA 1WY2A 4U6EA 2GG2A 4JUQA 2GG0A 3CTZA 1N51A 1JAWA 3FMRA 2P9AA 5FCFA 2OKNA 3CB5A 1YW8A 2BHCA 2Q95A 2BWSA 1C21A 3S6BA 3MX6A 1KQ0A 3FM3A 4ZWOA 2GG5A 4IKUA 1MATA 2BWVA 4EGEA 5D6FA 2ZSGA 1WBQA 4FUKA 2G6PA 4RZYA 4U1BA 2GGBA 4FLIA 4U6JA 4FLJA 4QR8A 4A6WA 2EA4A 4RZZA 5CDEA 5D6EA 4U71A 4ZWUA 4RGZ1 2EA2A 1XGSA 2GU5A 3CB6A 3MR1A 4U69A 4Z7MA 2P99A 1C23A 2B3LA 1QXWA 2OAZA 4S2TP 3IG4A 4FKCA 4PV4A 2B3HA 4B28A 2GU6A 4U6CA 2GTXA 3BITA 2EVMA 5CE6A 5CLSA 4FO7A 1YJ3A 3IU9A 2BN7A 2NQ6A 4IKTA 4KM3A 5CDVA 1C27A 3D27A 2EVOA 4U6WA 5JHUA 4R60A 2ADUA 3PN9A 2BB7A 2V3XA 3PKEA 2HOWA 1C22A 3I7MA 2GZ5A 3BIPA 5CDLA 4IECA 2BH3A 1O0XA 2V3ZA 4FLLA 4U70A 1BOAA 1XGNA 3PEBA 2P98A 4S2RP 1WL9A 1YW7A 4IDYA 3RVAA 4OOKA 2EVCA 3Q6DA 1XGOA 3IU8A 3FMQA 3L24A 4S01A 1W2MA 2BWWA 3O5VA 5E2CA 2GG8A 2MATA 4U76A 2BWYA 5CNXA 2Q96A 2V6CA 2Q92A 3MATA 1B6AA 4U6ZA 2Q93A 1WN1A 2GU7A 4FLKA 1QZYA 1CHMA 3TAVA 1XNZA 1C24A 2NQ7A 4U75A 3RORA 4A6VA 3IU7A 3QOCA 2V3YA 5JFRA 4S00A 1KP0A 3BIQA 1KQ9A 3OVKA
chains in the Genus database with same CATH superfamily
2GGCA 2Q94A 3PKCA 2BWTA 1WL6A 1B59A 4IF7A 1WLRA 4ZWPA 3PKBA 1A16A 5CIKA 4MATA 3PKAA 1W7VA 4IKSA 4IKRA 2BHAA 2BWUA 2B3KA 3OOOA 4ZNGA 1YVMA 3PKDA 2IW2A 1QXZA 2GU4A 4HXXA 2GG9A 2GG7A 2BHBA 4PNCA 2GA2A 1R58A 5E5BA 1R5HA 1R5GA 3IL0A 2DFIA 4IPAA 3TB5A 1PV9A 3L7GA 5FCHA 1BN5A 1XGMA 2BHDA 1YW9A 4FO8A 4U73A 5JI6A 1QXYA 1Y1NA 4IU6A 2BWXA 1M35A 2GG3A 2Q8KA 1WKMA 1WY2A 4U6EA 2GG2A 4JUQA 2GG0A 3CTZA 1N51A 1JAWA 3FMRA 2P9AA 5FCFA 2OKNA 3CB5A 1YW8A 2BHCA 2Q95A 2BWSA 1C21A 3S6BA 3MX6A 1KQ0A 3FM3A 4ZWOA 2GG5A 4IKUA 1MATA 2BWVA 4EGEA 5D6FA 2ZSGA 1WBQA 4FUKA 2G6PA 4RZYA 4U1BA 2GGBA 4FLIA 4U6JA 4FLJA 4QR8A 4A6WA 2EA4A 4RZZA 5CDEA 5D6EA 4U71A 4ZWUA 4RGZ1 2EA2A 1XGSA 2GU5A 3CB6A 3MR1A 4U69A 4Z7MA 2P99A 1C23A 2B3LA 1QXWA 2OAZA 4S2TP 3IG4A 4FKCA 4PV4A 2B3HA 4B28A 2GU6A 4U6CA 2GTXA 3BITA 2EVMA 5CE6A 5CLSA 4FO7A 1YJ3A 3IU9A 2BN7A 2NQ6A 4IKTA 4KM3A 5CDVA 1C27A 3D27A 2EVOA 4U6WA 5JHUA 4R60A 2ADUA 3PN9A 2BB7A 2V3XA 3PKEA 2HOWA 1C22A 3I7MA 2GZ5A 3BIPA 5CDLA 4IECA 2BH3A 1O0XA 2V3ZA 4FLLA 4U70A 1BOAA 1XGNA 3PEBA 2P98A 4S2RP 1WL9A 1YW7A 4IDYA 3RVAA 4OOKA 2EVCA 3Q6DA 1XGOA 3IU8A 3FMQA 3L24A 4S01A 1W2MA 2BWWA 3O5VA 5E2CA 2GG8A 2MATA 4U76A 2BWYA 5CNXA 2Q96A 2V6CA 2Q92A 3MATA 1B6AA 4U6ZA 2Q93A 1WN1A 2GU7A 4FLKA 1QZYA 1CHMA 3TAVA 1XNZA 1C24A 2NQ7A 4U75A 3RORA 4A6VA 3IU7A 3QOCA 2V3YA 5JFRA 4S00A 1KP0A 3BIQA 1KQ9A 3OVKA
chains in the Genus database with same CATH topology
2GGCA 2Q94A 3PKCA 2BWTA 1WL6A 1B59A 4IF7A 1WLRA 4ZWPA 3PKBA 1A16A 5CIKA 4MATA 3PKAA 1W7VA 4IKSA 4IKRA 2BHAA 2BWUA 2B3KA 3OOOA 4ZNGA 1YVMA 3PKDA 2IW2A 1QXZA 2GU4A 4HXXA 2GG9A 2GG7A 2BHBA 4PNCA 2GA2A 1R58A 5E5BA 1R5HA 1R5GA 3IL0A 2DFIA 4IPAA 3TB5A 1PV9A 3L7GA 5FCHA 1BN5A 1XGMA 2BHDA 1YW9A 4FO8A 4U73A 5JI6A 1QXYA 1Y1NA 4IU6A 2BWXA 1M35A 2GG3A 2Q8KA 1WKMA 1WY2A 4U6EA 2GG2A 4JUQA 2GG0A 3CTZA 1N51A 1JAWA 3FMRA 2P9AA 5FCFA 2OKNA 3CB5A 1YW8A 2BHCA 2Q95A 2BWSA 1C21A 3S6BA 3MX6A 1KQ0A 3FM3A 4ZWOA 2GG5A 4IKUA 1MATA 2BWVA 4EGEA 5D6FA 2ZSGA 1WBQA 4FUKA 2G6PA 4RZYA 4U1BA 2GGBA 4FLIA 4U6JA 4FLJA 4QR8A 4A6WA 2EA4A 4RZZA 5CDEA 5D6EA 4U71A 4ZWUA 4RGZ1 2EA2A 1XGSA 2GU5A 3CB6A 3MR1A 4U69A 4Z7MA 2P99A 1C23A 2B3LA 1QXWA 2OAZA 4S2TP 3IG4A 4FKCA 4PV4A 2B3HA 4B28A 2GU6A 4U6CA 2GTXA 3BITA 2EVMA 5CE6A 5CLSA 4FO7A 1YJ3A 3IU9A 2BN7A 2NQ6A 4IKTA 4KM3A 5CDVA 1C27A 3D27A 2EVOA 4U6WA 5JHUA 4R60A 2ADUA 3PN9A 2BB7A 2V3XA 3PKEA 2HOWA 1C22A 3I7MA 2GZ5A 3BIPA 5CDLA 4IECA 2BH3A 1O0XA 2V3ZA 4FLLA 4U70A 1BOAA 1XGNA 3PEBA 2P98A 4S2RP 1WL9A 1YW7A 4IDYA 3RVAA 4OOKA 2EVCA 3Q6DA 1XGOA 3IU8A 3FMQA 3L24A 4S01A 1W2MA 2BWWA 3O5VA 5E2CA 2GG8A 2MATA 4U76A 2BWYA 5CNXA 2Q96A 2V6CA 2Q92A 3MATA 1B6AA 4U6ZA 2Q93A 1WN1A 2GU7A 4FLKA 1QZYA 1CHMA 3TAVA 1XNZA 1C24A 2NQ7A 4U75A 3RORA 4A6VA 3IU7A 3QOCA 2V3YA 5JFRA 4S00A 1KP0A 3BIQA 1KQ9A 3OVKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GGC A;  2Q94 A;  3PKC A;  2BWT A;  1WL6 A;  1B59 A;  4IF7 A;  1WLR A;  4ZWP A;  3PKB A;  1A16 A;  5CIK A;  4MAT A;  3PKA A;  1W7V A;  4IKS A;  4IKR A;  2BHA A;  2BWU A;  2B3K A;  3OOO A;  4ZNG A;  1YVM A;  3PKD A;  2IW2 A;  1QXZ A;  2GU4 A;  4HXX A;  2GG9 A;  2GG7 A;  2BHB A;  4PNC A;  2GA2 A;  1R58 A;  5E5B A;  1R5H A;  1R5G A;  3IL0 A;  2DFI A;  4IPA A;  3TB5 A;  1PV9 A;  3L7G A;  5FCH A;  1BN5 A;  1XGM A;  2BHD A;  1YW9 A;  4FO8 A;  4U73 A;  5JI6 A;  1QXY A;  1Y1N A;  4IU6 A;  2BWX A;  1M35 A;  2GG3 A;  2Q8K A;  1WKM A;  1WY2 A;  4U6E A;  2GG2 A;  4JUQ A;  2GG0 A;  3CTZ A;  1N51 A;  1JAW A;  3FMR A;  2P9A A;  5FCF A;  2OKN A;  3CB5 A;  1YW8 A;  2BHC A;  2Q95 A;  2BWS A;  1C21 A;  3S6B A;  3MX6 A;  1KQ0 A;  3FM3 A;  4ZWO A;  2GG5 A;  4IKU A;  1MAT A;  2BWV A;  4EGE A;  5D6F A;  2ZSG A;  1WBQ A;  4FUK A;  2G6P A;  4RZY A;  4U1B A;  2GGB A;  4FLI A;  4U6J A;  4FLJ A;  4QR8 A;  4A6W A;  2EA4 A;  4RZZ A;  5CDE A;  5D6E A;  4U71 A;  4ZWU A;  4RGZ 1;  2EA2 A;  1XGS A;  2GU5 A;  3CB6 A;  3MR1 A;  4U69 A;  4Z7M A;  2P99 A;  1C23 A;  2B3L A;  1QXW A;  2OAZ A;  4S2T P;  3IG4 A;  4FKC A;  4PV4 A;  2B3H A;  4B28 A;  2GU6 A;  4U6C A;  2GTX A;  3BIT A;  2EVM A;  5CE6 A;  5CLS A;  4FO7 A;  1YJ3 A;  3IU9 A;  2BN7 A;  2NQ6 A;  4IKT A;  4KM3 A;  5CDV A;  1C27 A;  3D27 A;  2EVO A;  4U6W A;  5JHU A;  4R60 A;  2ADU A;  3PN9 A;  2BB7 A;  2V3X A;  3PKE A;  2HOW A;  1C22 A;  3I7M A;  2GZ5 A;  3BIP A;  5CDL A;  4IEC A;  2BH3 A;  1O0X A;  2V3Z A;  4FLL A;  4U70 A;  1BOA A;  1XGN A;  3PEB A;  2P98 A;  4S2R P;  1WL9 A;  1YW7 A;  4IDY A;  3RVA A;  4OOK A;  2EVC A;  3Q6D A;  1XGO A;  3IU8 A;  3FMQ A;  3L24 A;  4S01 A;  1W2M A;  2BWW A;  3O5V A;  5E2C A;  2GG8 A;  2MAT A;  4U76 A;  2BWY A;  5CNX A;  2Q96 A;  2V6C A;  2Q92 A;  3MAT A;  1B6A A;  4U6Z A;  2Q93 A;  1WN1 A;  2GU7 A;  4FLK A;  1QZY A;  1CHM A;  3TAV A;  1XNZ A;  1C24 A;  2NQ7 A;  4U75 A;  3ROR A;  4A6V A;  3IU7 A;  3QOC A;  2V3Y A;  5JFR A;  4S00 A;  1KP0 A;  3BIQ A;  1KQ9 A;  3OVK A; 
#chains in the Genus database with same CATH topology
 2GGC A;  2Q94 A;  3PKC A;  2BWT A;  1WL6 A;  1B59 A;  4IF7 A;  1WLR A;  4ZWP A;  3PKB A;  1A16 A;  5CIK A;  4MAT A;  3PKA A;  1W7V A;  4IKS A;  4IKR A;  2BHA A;  2BWU A;  2B3K A;  3OOO A;  4ZNG A;  1YVM A;  3PKD A;  2IW2 A;  1QXZ A;  2GU4 A;  4HXX A;  2GG9 A;  2GG7 A;  2BHB A;  4PNC A;  2GA2 A;  1R58 A;  5E5B A;  1R5H A;  1R5G A;  3IL0 A;  2DFI A;  4IPA A;  3TB5 A;  1PV9 A;  3L7G A;  5FCH A;  1BN5 A;  1XGM A;  2BHD A;  1YW9 A;  4FO8 A;  4U73 A;  5JI6 A;  1QXY A;  1Y1N A;  4IU6 A;  2BWX A;  1M35 A;  2GG3 A;  2Q8K A;  1WKM A;  1WY2 A;  4U6E A;  2GG2 A;  4JUQ A;  2GG0 A;  3CTZ A;  1N51 A;  1JAW A;  3FMR A;  2P9A A;  5FCF A;  2OKN A;  3CB5 A;  1YW8 A;  2BHC A;  2Q95 A;  2BWS A;  1C21 A;  3S6B A;  3MX6 A;  1KQ0 A;  3FM3 A;  4ZWO A;  2GG5 A;  4IKU A;  1MAT A;  2BWV A;  4EGE A;  5D6F A;  2ZSG A;  1WBQ A;  4FUK A;  2G6P A;  4RZY A;  4U1B A;  2GGB A;  4FLI A;  4U6J A;  4FLJ A;  4QR8 A;  4A6W A;  2EA4 A;  4RZZ A;  5CDE A;  5D6E A;  4U71 A;  4ZWU A;  4RGZ 1;  2EA2 A;  1XGS A;  2GU5 A;  3CB6 A;  3MR1 A;  4U69 A;  4Z7M A;  2P99 A;  1C23 A;  2B3L A;  1QXW A;  2OAZ A;  4S2T P;  3IG4 A;  4FKC A;  4PV4 A;  2B3H A;  4B28 A;  2GU6 A;  4U6C A;  2GTX A;  3BIT A;  2EVM A;  5CE6 A;  5CLS A;  4FO7 A;  1YJ3 A;  3IU9 A;  2BN7 A;  2NQ6 A;  4IKT A;  4KM3 A;  5CDV A;  1C27 A;  3D27 A;  2EVO A;  4U6W A;  5JHU A;  4R60 A;  2ADU A;  3PN9 A;  2BB7 A;  2V3X A;  3PKE A;  2HOW A;  1C22 A;  3I7M A;  2GZ5 A;  3BIP A;  5CDL A;  4IEC A;  2BH3 A;  1O0X A;  2V3Z A;  4FLL A;  4U70 A;  1BOA A;  1XGN A;  3PEB A;  2P98 A;  4S2R P;  1WL9 A;  1YW7 A;  4IDY A;  3RVA A;  4OOK A;  2EVC A;  3Q6D A;  1XGO A;  3IU8 A;  3FMQ A;  3L24 A;  4S01 A;  1W2M A;  2BWW A;  3O5V A;  5E2C A;  2GG8 A;  2MAT A;  4U76 A;  2BWY A;  5CNX A;  2Q96 A;  2V6C A;  2Q92 A;  3MAT A;  1B6A A;  4U6Z A;  2Q93 A;  1WN1 A;  2GU7 A;  4FLK A;  1QZY A;  1CHM A;  3TAV A;  1XNZ A;  1C24 A;  2NQ7 A;  4U75 A;  3ROR A;  4A6V A;  3IU7 A;  3QOC A;  2V3Y A;  5JFR A;  4S00 A;  1KP0 A;  3BIQ A;  1KQ9 A;  3OVK A; 
#chains in the Genus database with same CATH homology
 2GGC A;  2Q94 A;  3PKC A;  2BWT A;  1WL6 A;  1B59 A;  4IF7 A;  1WLR A;  4ZWP A;  3PKB A;  1A16 A;  5CIK A;  4MAT A;  3PKA A;  1W7V A;  4IKS A;  4IKR A;  2BHA A;  2BWU A;  2B3K A;  3OOO A;  4ZNG A;  1YVM A;  3PKD A;  2IW2 A;  1QXZ A;  2GU4 A;  4HXX A;  2GG9 A;  2GG7 A;  2BHB A;  4PNC A;  2GA2 A;  1R58 A;  5E5B A;  1R5H A;  1R5G A;  3IL0 A;  2DFI A;  4IPA A;  3TB5 A;  1PV9 A;  3L7G A;  5FCH A;  1BN5 A;  1XGM A;  2BHD A;  1YW9 A;  4FO8 A;  4U73 A;  5JI6 A;  1QXY A;  1Y1N A;  4IU6 A;  2BWX A;  1M35 A;  2GG3 A;  2Q8K A;  1WKM A;  1WY2 A;  4U6E A;  2GG2 A;  4JUQ A;  2GG0 A;  3CTZ A;  1N51 A;  1JAW A;  3FMR A;  2P9A A;  5FCF A;  2OKN A;  3CB5 A;  1YW8 A;  2BHC A;  2Q95 A;  2BWS A;  1C21 A;  3S6B A;  3MX6 A;  1KQ0 A;  3FM3 A;  4ZWO A;  2GG5 A;  4IKU A;  1MAT A;  2BWV A;  4EGE A;  5D6F A;  2ZSG A;  1WBQ A;  4FUK A;  2G6P A;  4RZY A;  4U1B A;  2GGB A;  4FLI A;  4U6J A;  4FLJ A;  4QR8 A;  4A6W A;  2EA4 A;  4RZZ A;  5CDE A;  5D6E A;  4U71 A;  4ZWU A;  4RGZ 1;  2EA2 A;  1XGS A;  2GU5 A;  3CB6 A;  3MR1 A;  4U69 A;  4Z7M A;  2P99 A;  1C23 A;  2B3L A;  1QXW A;  2OAZ A;  4S2T P;  3IG4 A;  4FKC A;  4PV4 A;  2B3H A;  4B28 A;  2GU6 A;  4U6C A;  2GTX A;  3BIT A;  2EVM A;  5CE6 A;  5CLS A;  4FO7 A;  1YJ3 A;  3IU9 A;  2BN7 A;  2NQ6 A;  4IKT A;  4KM3 A;  5CDV A;  1C27 A;  3D27 A;  2EVO A;  4U6W A;  5JHU A;  4R60 A;  2ADU A;  3PN9 A;  2BB7 A;  2V3X A;  3PKE A;  2HOW A;  1C22 A;  3I7M A;  2GZ5 A;  3BIP A;  5CDL A;  4IEC A;  2BH3 A;  1O0X A;  2V3Z A;  4FLL A;  4U70 A;  1BOA A;  1XGN A;  3PEB A;  2P98 A;  4S2R P;  1WL9 A;  1YW7 A;  4IDY A;  3RVA A;  4OOK A;  2EVC A;  3Q6D A;  1XGO A;  3IU8 A;  3FMQ A;  3L24 A;  4S01 A;  1W2M A;  2BWW A;  3O5V A;  5E2C A;  2GG8 A;  2MAT A;  4U76 A;  2BWY A;  5CNX A;  2Q96 A;  2V6C A;  2Q92 A;  3MAT A;  1B6A A;  4U6Z A;  2Q93 A;  1WN1 A;  2GU7 A;  4FLK A;  1QZY A;  1CHM A;  3TAV A;  1XNZ A;  1C24 A;  2NQ7 A;  4U75 A;  3ROR A;  4A6V A;  3IU7 A;  3QOC A;  2V3Y A;  5JFR A;  4S00 A;  1KP0 A;  3BIQ A;  1KQ9 A;  3OVK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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