2IW2A

Crystal structure of human prolidase
Total Genus 170
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
170
sequence length
477
structure length
477
Chain Sequence
GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords XAA-PRO DIPEPTIDASE
publication title Crystal Structure of Human Prolidase: The Molecular Basis of Pd Disease
rcsb
source organism Homo sapiens
total genus 170
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2006-06-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2iw2A01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2iw2A02
1WN1A 3S6BA 3PKBA 4IKRA 4OOKA 2BB7A 3TB5A 1XGMA 2EVCA 2BWXA 4U69A 1WKMA 2ZSGA 1YW9A 2Q95A 5CDVA 4S2TP 4ZWOA 4ZWUA 1KQ0A 2EVMA 1R5HA 1CHMA 4IKSA 2BWUA 1C22A 2P9AA 1YW7A 4U6ZA 3IU7A 1B6AA 4FKCA 5E2CA 3IG4A 4FLKA 2EA4A 3I7MA 4S01A 1WLRA 3PEBA 3D27A 2GG7A 1M35A 3L24A 2OKNA 2ADUA 3FMQA 2IW2A 1KQ9A 4IKUA 4U6CA 4FUKA 1C23A 2NQ6A 2GG0A 4IKTA 2GU5A 4MATA 4U75A 2BHAA 1PV9A 1Y1NA 1BN5A 4S2RP 3MR1A 5CE6A 1W7VA 2P98A 2P99A 1WBQA 3CTZA 2Q8KA 4B28A 1MATA 4ZWPA 1QXZA 2B3LA 2Q93A 5JFRA 2V6CA 3RVAA 1C27A 4PNCA 2HOWA 2NQ7A 1W2MA 4IPAA 3BIQA 3OVKA 3FMRA 4U6WA 4Z7MA 1O0XA 4ZNGA 3BIPA 4FLJA 1KP0A 3MATA 4RGZ1 2MATA 1YJ3A 3CB5A 4FLIA 5JHUA 2BWVA 2BH3A 3PN9A 1BOAA 2GG8A 3TAVA 3PKAA 4JUQA 3PKDA 4KM3A 4U76A 4U73A 5JI6A 4U70A 2GGBA 2BWTA 5CLSA 5E5BA 1WL9A 2Q94A 4U6JA 4EGEA 2Q96A 3PKCA 1C24A 4U6EA 2GG5A 4A6VA 3CB6A 1B59A 4FO8A 1JAWA 1WL6A 4S00A 2OAZA 4FO7A 4U1BA 5FCFA 2GZ5A 4HXXA 5CDEA 1YVMA 2BHCA 1XNZA 3PKEA 2V3YA 4PV4A 1QXWA 3FM3A 1A16A 5CDLA 2BHDA 1QZYA 2EVOA 3IU9A 3L7GA 1WY2A 2B3KA 2BWSA 2BWWA 5CNXA 1XGSA 2GU4A 2V3ZA 3IL0A 2G6PA 4A6WA 3OOOA 2BN7A 3Q6DA 5D6EA 4IDYA 1XGOA 4R60A 1YW8A 3IU8A 3MX6A 2V3XA 2BWYA 2EA2A 3BITA 2B3HA 4RZZA 2GU7A 1QXYA 1R58A 2Q92A 1R5GA 2GG9A 2GU6A 1N51A 4QR8A 3O5VA 2DFIA 3QOCA 4IU6A 5CIKA 2GA2A 4IECA 2GG2A 4U71A 2GGCA 4RZYA 5FCHA 2BHBA 1XGNA 2GG3A 1C21A 4FLLA 3RORA 5D6FA 2GTXA 4IF7A
chains in the Genus database with same CATH superfamily
1WN1A 3S6BA 3PKBA 4IKRA 4OOKA 2BB7A 3TB5A 1XGMA 2EVCA 2BWXA 4U69A 1WKMA 2ZSGA 1YW9A 2Q95A 5CDVA 4S2TP 4ZWOA 4ZWUA 1KQ0A 2EVMA 1R5HA 1CHMA 4IKSA 2BWUA 1C22A 2P9AA 1YW7A 4U6ZA 3IU7A 1B6AA 4FKCA 5E2CA 3IG4A 4FLKA 2EA4A 3I7MA 4S01A 1WLRA 3PEBA 3D27A 2GG7A 1M35A 3L24A 2OKNA 2ADUA 3FMQA 2IW2A 1KQ9A 4IKUA 4U6CA 4FUKA 1C23A 2NQ6A 2GG0A 4IKTA 2GU5A 4MATA 4U75A 2BHAA 1PV9A 1Y1NA 1BN5A 4S2RP 3MR1A 5CE6A 1W7VA 2P98A 2P99A 1WBQA 3CTZA 2Q8KA 4B28A 1MATA 4ZWPA 1QXZA 2B3LA 2Q93A 5JFRA 2V6CA 3RVAA 1C27A 4PNCA 2HOWA 2NQ7A 1W2MA 4IPAA 3BIQA 3OVKA 3FMRA 4U6WA 4Z7MA 1O0XA 4ZNGA 3BIPA 4FLJA 1KP0A 3MATA 4RGZ1 2MATA 1YJ3A 3CB5A 4FLIA 5JHUA 2BWVA 2BH3A 3PN9A 1BOAA 2GG8A 3TAVA 3PKAA 4JUQA 3PKDA 4KM3A 4U76A 4U73A 5JI6A 4U70A 2GGBA 2BWTA 5CLSA 5E5BA 1WL9A 2Q94A 4U6JA 4EGEA 2Q96A 3PKCA 1C24A 4U6EA 2GG5A 4A6VA 3CB6A 1B59A 4FO8A 1JAWA 1WL6A 4S00A 2OAZA 4FO7A 4U1BA 5FCFA 2GZ5A 4HXXA 5CDEA 1YVMA 2BHCA 1XNZA 3PKEA 2V3YA 4PV4A 1QXWA 3FM3A 1A16A 5CDLA 2BHDA 1QZYA 2EVOA 3IU9A 3L7GA 1WY2A 2B3KA 2BWSA 2BWWA 5CNXA 1XGSA 2GU4A 2V3ZA 3IL0A 2G6PA 4A6WA 3OOOA 2BN7A 3Q6DA 5D6EA 4IDYA 1XGOA 4R60A 1YW8A 3IU8A 3MX6A 2V3XA 2BWYA 2EA2A 3BITA 2B3HA 4RZZA 2GU7A 1QXYA 1R58A 2Q92A 1R5GA 2GG9A 2GU6A 1N51A 4QR8A 3O5VA 2DFIA 3QOCA 4IU6A 5CIKA 2GA2A 4IECA 2GG2A 4U71A 2GGCA 4RZYA 5FCHA 2BHBA 1XGNA 2GG3A 1C21A 4FLLA 3RORA 5D6FA 2GTXA 4IF7A
chains in the Genus database with same CATH topology
1WN1A 3S6BA 3PKBA 4IKRA 4OOKA 2BB7A 3TB5A 1XGMA 2EVCA 2BWXA 4U69A 1WKMA 2ZSGA 1YW9A 2Q95A 5CDVA 4S2TP 4ZWOA 4ZWUA 1KQ0A 2EVMA 1R5HA 1CHMA 4IKSA 2BWUA 1C22A 2P9AA 1YW7A 4U6ZA 3IU7A 1B6AA 4FKCA 5E2CA 3IG4A 4FLKA 2EA4A 3I7MA 4S01A 1WLRA 3PEBA 3D27A 2GG7A 1M35A 3L24A 2OKNA 2ADUA 3FMQA 2IW2A 1KQ9A 4IKUA 4U6CA 4FUKA 1C23A 2NQ6A 2GG0A 4IKTA 2GU5A 4MATA 4U75A 2BHAA 1PV9A 1Y1NA 1BN5A 4S2RP 3MR1A 5CE6A 1W7VA 2P98A 2P99A 1WBQA 3CTZA 2Q8KA 4B28A 1MATA 4ZWPA 1QXZA 2B3LA 2Q93A 5JFRA 2V6CA 3RVAA 1C27A 4PNCA 2HOWA 2NQ7A 1W2MA 4IPAA 3BIQA 3OVKA 3FMRA 4U6WA 4Z7MA 1O0XA 4ZNGA 3BIPA 4FLJA 1KP0A 3MATA 4RGZ1 2MATA 1YJ3A 3CB5A 4FLIA 5JHUA 2BWVA 2BH3A 3PN9A 1BOAA 2GG8A 3TAVA 3PKAA 4JUQA 3PKDA 4KM3A 4U76A 4U73A 5JI6A 4U70A 2GGBA 2BWTA 5CLSA 5E5BA 1WL9A 2Q94A 4U6JA 4EGEA 2Q96A 3PKCA 1C24A 4U6EA 2GG5A 4A6VA 3CB6A 1B59A 4FO8A 1JAWA 1WL6A 4S00A 2OAZA 4FO7A 4U1BA 5FCFA 2GZ5A 4HXXA 5CDEA 1YVMA 2BHCA 1XNZA 3PKEA 2V3YA 4PV4A 1QXWA 3FM3A 1A16A 5CDLA 2BHDA 1QZYA 2EVOA 3IU9A 3L7GA 1WY2A 2B3KA 2BWSA 2BWWA 5CNXA 1XGSA 2GU4A 2V3ZA 3IL0A 2G6PA 4A6WA 3OOOA 2BN7A 3Q6DA 5D6EA 4IDYA 1XGOA 4R60A 1YW8A 3IU8A 3MX6A 2V3XA 2BWYA 2EA2A 3BITA 2B3HA 4RZZA 2GU7A 1QXYA 1R58A 2Q92A 1R5GA 2GG9A 2GU6A 1N51A 4QR8A 3O5VA 2DFIA 3QOCA 4IU6A 5CIKA 2GA2A 4IECA 2GG2A 4U71A 2GGCA 4RZYA 5FCHA 2BHBA 1XGNA 2GG3A 1C21A 4FLLA 3RORA 5D6FA 2GTXA 4IF7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WN1 A;  3S6B A;  3PKB A;  4IKR A;  4OOK A;  2BB7 A;  3TB5 A;  1XGM A;  2EVC A;  2BWX A;  4U69 A;  1WKM A;  2ZSG A;  1YW9 A;  2Q95 A;  5CDV A;  4S2T P;  4ZWO A;  4ZWU A;  1KQ0 A;  2EVM A;  1R5H A;  1CHM A;  4IKS A;  2BWU A;  1C22 A;  2P9A A;  1YW7 A;  4U6Z A;  3IU7 A;  1B6A A;  4FKC A;  5E2C A;  3IG4 A;  4FLK A;  2EA4 A;  3I7M A;  4S01 A;  1WLR A;  3PEB A;  3D27 A;  2GG7 A;  1M35 A;  3L24 A;  2OKN A;  2ADU A;  3FMQ A;  2IW2 A;  1KQ9 A;  4IKU A;  4U6C A;  4FUK A;  1C23 A;  2NQ6 A;  2GG0 A;  4IKT A;  2GU5 A;  4MAT A;  4U75 A;  2BHA A;  1PV9 A;  1Y1N A;  1BN5 A;  4S2R P;  3MR1 A;  5CE6 A;  1W7V A;  2P98 A;  2P99 A;  1WBQ A;  3CTZ A;  2Q8K A;  4B28 A;  1MAT A;  4ZWP A;  1QXZ A;  2B3L A;  2Q93 A;  5JFR A;  2V6C A;  3RVA A;  1C27 A;  4PNC A;  2HOW A;  2NQ7 A;  1W2M A;  4IPA A;  3BIQ A;  3OVK A;  3FMR A;  4U6W A;  4Z7M A;  1O0X A;  4ZNG A;  3BIP A;  4FLJ A;  1KP0 A;  3MAT A;  4RGZ 1;  2MAT A;  1YJ3 A;  3CB5 A;  4FLI A;  5JHU A;  2BWV A;  2BH3 A;  3PN9 A;  1BOA A;  2GG8 A;  3TAV A;  3PKA A;  4JUQ A;  3PKD A;  4KM3 A;  4U76 A;  4U73 A;  5JI6 A;  4U70 A;  2GGB A;  2BWT A;  5CLS A;  5E5B A;  1WL9 A;  2Q94 A;  4U6J A;  4EGE A;  2Q96 A;  3PKC A;  1C24 A;  4U6E A;  2GG5 A;  4A6V A;  3CB6 A;  1B59 A;  4FO8 A;  1JAW A;  1WL6 A;  4S00 A;  2OAZ A;  4FO7 A;  4U1B A;  5FCF A;  2GZ5 A;  4HXX A;  5CDE A;  1YVM A;  2BHC A;  1XNZ A;  3PKE A;  2V3Y A;  4PV4 A;  1QXW A;  3FM3 A;  1A16 A;  5CDL A;  2BHD A;  1QZY A;  2EVO A;  3IU9 A;  3L7G A;  1WY2 A;  2B3K A;  2BWS A;  2BWW A;  5CNX A;  1XGS A;  2GU4 A;  2V3Z A;  3IL0 A;  2G6P A;  4A6W A;  3OOO A;  2BN7 A;  3Q6D A;  5D6E A;  4IDY A;  1XGO A;  4R60 A;  1YW8 A;  3IU8 A;  3MX6 A;  2V3X A;  2BWY A;  2EA2 A;  3BIT A;  2B3H A;  4RZZ A;  2GU7 A;  1QXY A;  1R58 A;  2Q92 A;  1R5G A;  2GG9 A;  2GU6 A;  1N51 A;  4QR8 A;  3O5V A;  2DFI A;  3QOC A;  4IU6 A;  5CIK A;  2GA2 A;  4IEC A;  2GG2 A;  4U71 A;  2GGC A;  4RZY A;  5FCH A;  2BHB A;  1XGN A;  2GG3 A;  1C21 A;  4FLL A;  3ROR A;  5D6F A;  2GTX A;  4IF7 A; 
#chains in the Genus database with same CATH topology
 1WN1 A;  3S6B A;  3PKB A;  4IKR A;  4OOK A;  2BB7 A;  3TB5 A;  1XGM A;  2EVC A;  2BWX A;  4U69 A;  1WKM A;  2ZSG A;  1YW9 A;  2Q95 A;  5CDV A;  4S2T P;  4ZWO A;  4ZWU A;  1KQ0 A;  2EVM A;  1R5H A;  1CHM A;  4IKS A;  2BWU A;  1C22 A;  2P9A A;  1YW7 A;  4U6Z A;  3IU7 A;  1B6A A;  4FKC A;  5E2C A;  3IG4 A;  4FLK A;  2EA4 A;  3I7M A;  4S01 A;  1WLR A;  3PEB A;  3D27 A;  2GG7 A;  1M35 A;  3L24 A;  2OKN A;  2ADU A;  3FMQ A;  2IW2 A;  1KQ9 A;  4IKU A;  4U6C A;  4FUK A;  1C23 A;  2NQ6 A;  2GG0 A;  4IKT A;  2GU5 A;  4MAT A;  4U75 A;  2BHA A;  1PV9 A;  1Y1N A;  1BN5 A;  4S2R P;  3MR1 A;  5CE6 A;  1W7V A;  2P98 A;  2P99 A;  1WBQ A;  3CTZ A;  2Q8K A;  4B28 A;  1MAT A;  4ZWP A;  1QXZ A;  2B3L A;  2Q93 A;  5JFR A;  2V6C A;  3RVA A;  1C27 A;  4PNC A;  2HOW A;  2NQ7 A;  1W2M A;  4IPA A;  3BIQ A;  3OVK A;  3FMR A;  4U6W A;  4Z7M A;  1O0X A;  4ZNG A;  3BIP A;  4FLJ A;  1KP0 A;  3MAT A;  4RGZ 1;  2MAT A;  1YJ3 A;  3CB5 A;  4FLI A;  5JHU A;  2BWV A;  2BH3 A;  3PN9 A;  1BOA A;  2GG8 A;  3TAV A;  3PKA A;  4JUQ A;  3PKD A;  4KM3 A;  4U76 A;  4U73 A;  5JI6 A;  4U70 A;  2GGB A;  2BWT A;  5CLS A;  5E5B A;  1WL9 A;  2Q94 A;  4U6J A;  4EGE A;  2Q96 A;  3PKC A;  1C24 A;  4U6E A;  2GG5 A;  4A6V A;  3CB6 A;  1B59 A;  4FO8 A;  1JAW A;  1WL6 A;  4S00 A;  2OAZ A;  4FO7 A;  4U1B A;  5FCF A;  2GZ5 A;  4HXX A;  5CDE A;  1YVM A;  2BHC A;  1XNZ A;  3PKE A;  2V3Y A;  4PV4 A;  1QXW A;  3FM3 A;  1A16 A;  5CDL A;  2BHD A;  1QZY A;  2EVO A;  3IU9 A;  3L7G A;  1WY2 A;  2B3K A;  2BWS A;  2BWW A;  5CNX A;  1XGS A;  2GU4 A;  2V3Z A;  3IL0 A;  2G6P A;  4A6W A;  3OOO A;  2BN7 A;  3Q6D A;  5D6E A;  4IDY A;  1XGO A;  4R60 A;  1YW8 A;  3IU8 A;  3MX6 A;  2V3X A;  2BWY A;  2EA2 A;  3BIT A;  2B3H A;  4RZZ A;  2GU7 A;  1QXY A;  1R58 A;  2Q92 A;  1R5G A;  2GG9 A;  2GU6 A;  1N51 A;  4QR8 A;  3O5V A;  2DFI A;  3QOC A;  4IU6 A;  5CIK A;  2GA2 A;  4IEC A;  2GG2 A;  4U71 A;  2GGC A;  4RZY A;  5FCH A;  2BHB A;  1XGN A;  2GG3 A;  1C21 A;  4FLL A;  3ROR A;  5D6F A;  2GTX A;  4IF7 A; 
#chains in the Genus database with same CATH homology
 1WN1 A;  3S6B A;  3PKB A;  4IKR A;  4OOK A;  2BB7 A;  3TB5 A;  1XGM A;  2EVC A;  2BWX A;  4U69 A;  1WKM A;  2ZSG A;  1YW9 A;  2Q95 A;  5CDV A;  4S2T P;  4ZWO A;  4ZWU A;  1KQ0 A;  2EVM A;  1R5H A;  1CHM A;  4IKS A;  2BWU A;  1C22 A;  2P9A A;  1YW7 A;  4U6Z A;  3IU7 A;  1B6A A;  4FKC A;  5E2C A;  3IG4 A;  4FLK A;  2EA4 A;  3I7M A;  4S01 A;  1WLR A;  3PEB A;  3D27 A;  2GG7 A;  1M35 A;  3L24 A;  2OKN A;  2ADU A;  3FMQ A;  2IW2 A;  1KQ9 A;  4IKU A;  4U6C A;  4FUK A;  1C23 A;  2NQ6 A;  2GG0 A;  4IKT A;  2GU5 A;  4MAT A;  4U75 A;  2BHA A;  1PV9 A;  1Y1N A;  1BN5 A;  4S2R P;  3MR1 A;  5CE6 A;  1W7V A;  2P98 A;  2P99 A;  1WBQ A;  3CTZ A;  2Q8K A;  4B28 A;  1MAT A;  4ZWP A;  1QXZ A;  2B3L A;  2Q93 A;  5JFR A;  2V6C A;  3RVA A;  1C27 A;  4PNC A;  2HOW A;  2NQ7 A;  1W2M A;  4IPA A;  3BIQ A;  3OVK A;  3FMR A;  4U6W A;  4Z7M A;  1O0X A;  4ZNG A;  3BIP A;  4FLJ A;  1KP0 A;  3MAT A;  4RGZ 1;  2MAT A;  1YJ3 A;  3CB5 A;  4FLI A;  5JHU A;  2BWV A;  2BH3 A;  3PN9 A;  1BOA A;  2GG8 A;  3TAV A;  3PKA A;  4JUQ A;  3PKD A;  4KM3 A;  4U76 A;  4U73 A;  5JI6 A;  4U70 A;  2GGB A;  2BWT A;  5CLS A;  5E5B A;  1WL9 A;  2Q94 A;  4U6J A;  4EGE A;  2Q96 A;  3PKC A;  1C24 A;  4U6E A;  2GG5 A;  4A6V A;  3CB6 A;  1B59 A;  4FO8 A;  1JAW A;  1WL6 A;  4S00 A;  2OAZ A;  4FO7 A;  4U1B A;  5FCF A;  2GZ5 A;  4HXX A;  5CDE A;  1YVM A;  2BHC A;  1XNZ A;  3PKE A;  2V3Y A;  4PV4 A;  1QXW A;  3FM3 A;  1A16 A;  5CDL A;  2BHD A;  1QZY A;  2EVO A;  3IU9 A;  3L7G A;  1WY2 A;  2B3K A;  2BWS A;  2BWW A;  5CNX A;  1XGS A;  2GU4 A;  2V3Z A;  3IL0 A;  2G6P A;  4A6W A;  3OOO A;  2BN7 A;  3Q6D A;  5D6E A;  4IDY A;  1XGO A;  4R60 A;  1YW8 A;  3IU8 A;  3MX6 A;  2V3X A;  2BWY A;  2EA2 A;  3BIT A;  2B3H A;  4RZZ A;  2GU7 A;  1QXY A;  1R58 A;  2Q92 A;  1R5G A;  2GG9 A;  2GU6 A;  1N51 A;  4QR8 A;  3O5V A;  2DFI A;  3QOC A;  4IU6 A;  5CIK A;  2GA2 A;  4IEC A;  2GG2 A;  4U71 A;  2GGC A;  4RZY A;  5FCH A;  2BHB A;  1XGN A;  2GG3 A;  1C21 A;  4FLL A;  3ROR A;  5D6F A;  2GTX A;  4IF7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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