2GZ5A

Human type 1 methionine aminopeptidase in complex with ovalicin at 1.1 ang
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule keywords Methionine aminopeptidase 1
publication title Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-05-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gz5A00
4RZZA 5CDLA 1QXWA 1YW8A 1B59A 1O0XA 1R5GA 4FLKA 4IKRA 4OOKA 4U75A 2GG5A 4B28A 4U70A 1WL9A 2GG7A 2GGCA 1KQ9A 2GU6A 4U73A 4U6EA 4FLIA 3MX6A 2B3KA 2Q94A 4U69A 2BHDA 2P98A 4Z7MA 4PV4A 2GG8A 2NQ7A 1R58A 4IF7A 4PNCA 3D27A 3CB5A 1JAWA 4FUKA 1A16A 3PKAA 1C24A 4IU6A 2GTXA 3FM3A 1QXYA 4ZWUA 1C21A 4QR8A 2B3HA 1YW7A 3PKBA 2Q96A 1QXZA 2GU4A 4ZWOA 2BH3A 4U1BA 2ADUA 2BWSA 3S6BA 1M35A 1KP0A 3RVAA 4S00A 2NQ6A 2GG2A 5CDEA 2BWXA 3L7GA 5FCHA 4MATA 2MATA 3RORA 5CE6A 3BITA 2OKNA 1W7VA 4IDYA 4ZNGA 2G6PA 2P9AA 2EVCA 3TB5A 4EGEA 1KQ0A 2EVOA 4KM3A 3CTZA 4U76A 4IPAA 4IECA 1WLRA 1C22A 4FO7A 2V6CA 1XGOA 2V3YA 4JUQA 5JFRA 2GU5A 1XNZA 2BWVA 4FO8A 1WY2A 3IU7A 2V3XA 4HXXA 4S2RP 5FCFA 2B3LA 2GG3A 2HOWA 4RGZ1 4U6ZA 2BWTA 3FMRA 3IU9A 1WBQA 5JI6A 3PKCA 4IKTA 2Q92A 2BB7A 2DFIA 2IW2A 3PKEA 1CHMA 1BOAA 3BIPA 3IU8A 1PV9A 2BN7A 2EA2A 2GZ5A 3IG4A 5CLSA 2GGBA 1YJ3A 2P99A 3BIQA 5JHUA 4A6WA 1XGNA 1N51A 1Y1NA 5CIKA 4U6JA 1XGMA 4FLLA 2BWUA 4RZYA 4R60A 2Q95A 4IKUA 5CNXA 3CB6A 2GG0A 2GA2A 3MATA 3MR1A 2OAZA 3FMQA 5E5BA 5D6EA 1BN5A 2GU7A 4ZWPA 4U6WA 3L24A 4S01A 2ZSGA 2BHBA 1B6AA 2EA4A 4U71A 1R5HA 4FLJA 1YW9A 1WL6A 2Q8KA 4A6VA 1C27A 1WKMA 2GG9A 2Q93A 3Q6DA 4IKSA 3PKDA 1W2MA 1MATA 4S2TP 1QZYA 1C23A 1YVMA 4U6CA 2BHAA 4FKCA 3TAVA 2BWWA 5CDVA 1XGSA 2EVMA 5D6FA 2BWYA 1WN1A 2BHCA 2V3ZA
chains in the Genus database with same CATH superfamily
4RZZA 5CDLA 1QXWA 1YW8A 1B59A 1O0XA 1R5GA 4FLKA 4IKRA 4OOKA 4U75A 2GG5A 4B28A 4U70A 1WL9A 2GG7A 2GGCA 1KQ9A 2GU6A 4U73A 4U6EA 4FLIA 3MX6A 2B3KA 2Q94A 4U69A 2BHDA 2P98A 4Z7MA 4PV4A 2GG8A 2NQ7A 1R58A 4IF7A 4PNCA 3D27A 3CB5A 1JAWA 4FUKA 1A16A 3PKAA 1C24A 4IU6A 2GTXA 3FM3A 1QXYA 4ZWUA 1C21A 4QR8A 2B3HA 1YW7A 3PKBA 2Q96A 1QXZA 2GU4A 4ZWOA 2BH3A 4U1BA 2ADUA 2BWSA 3S6BA 1M35A 1KP0A 3RVAA 4S00A 2NQ6A 2GG2A 5CDEA 2BWXA 3L7GA 5FCHA 4MATA 2MATA 3RORA 5CE6A 3BITA 2OKNA 1W7VA 4IDYA 4ZNGA 2G6PA 2P9AA 2EVCA 3TB5A 4EGEA 1KQ0A 2EVOA 4KM3A 3CTZA 4U76A 4IPAA 4IECA 1WLRA 1C22A 4FO7A 2V6CA 1XGOA 2V3YA 4JUQA 5JFRA 2GU5A 1XNZA 2BWVA 4FO8A 1WY2A 3IU7A 2V3XA 4HXXA 4S2RP 5FCFA 2B3LA 2GG3A 2HOWA 4RGZ1 4U6ZA 2BWTA 3FMRA 3IU9A 1WBQA 5JI6A 3PKCA 4IKTA 2Q92A 2BB7A 2DFIA 2IW2A 3PKEA 1CHMA 1BOAA 3BIPA 3IU8A 1PV9A 2BN7A 2EA2A 2GZ5A 3IG4A 5CLSA 2GGBA 1YJ3A 2P99A 3BIQA 5JHUA 4A6WA 1XGNA 1N51A 1Y1NA 5CIKA 4U6JA 1XGMA 4FLLA 2BWUA 4RZYA 4R60A 2Q95A 4IKUA 5CNXA 3CB6A 2GG0A 2GA2A 3MATA 3MR1A 2OAZA 3FMQA 5E5BA 5D6EA 1BN5A 2GU7A 4ZWPA 4U6WA 3L24A 4S01A 2ZSGA 2BHBA 1B6AA 2EA4A 4U71A 1R5HA 4FLJA 1YW9A 1WL6A 2Q8KA 4A6VA 1C27A 1WKMA 2GG9A 2Q93A 3Q6DA 4IKSA 3PKDA 1W2MA 1MATA 4S2TP 1QZYA 1C23A 1YVMA 4U6CA 2BHAA 4FKCA 3TAVA 2BWWA 5CDVA 1XGSA 2EVMA 5D6FA 2BWYA 1WN1A 2BHCA 2V3ZA
chains in the Genus database with same CATH topology
4RZZA 5CDLA 1QXWA 1YW8A 1B59A 1O0XA 1R5GA 4FLKA 4IKRA 4OOKA 4U75A 2GG5A 4B28A 4U70A 1WL9A 2GG7A 2GGCA 1KQ9A 2GU6A 4U73A 4U6EA 4FLIA 3MX6A 2B3KA 2Q94A 4U69A 2BHDA 2P98A 4Z7MA 4PV4A 2GG8A 2NQ7A 1R58A 4IF7A 4PNCA 3D27A 3CB5A 1JAWA 4FUKA 1A16A 3PKAA 1C24A 4IU6A 2GTXA 3FM3A 1QXYA 4ZWUA 1C21A 4QR8A 2B3HA 1YW7A 3PKBA 2Q96A 1QXZA 2GU4A 4ZWOA 2BH3A 4U1BA 2ADUA 2BWSA 3S6BA 1M35A 1KP0A 3RVAA 4S00A 2NQ6A 2GG2A 5CDEA 2BWXA 3L7GA 5FCHA 4MATA 2MATA 3RORA 5CE6A 3BITA 2OKNA 1W7VA 4IDYA 4ZNGA 2G6PA 2P9AA 2EVCA 3TB5A 4EGEA 1KQ0A 2EVOA 4KM3A 3CTZA 4U76A 4IPAA 4IECA 1WLRA 1C22A 4FO7A 2V6CA 1XGOA 2V3YA 4JUQA 5JFRA 2GU5A 1XNZA 2BWVA 4FO8A 1WY2A 3IU7A 2V3XA 4HXXA 4S2RP 5FCFA 2B3LA 2GG3A 2HOWA 4RGZ1 4U6ZA 2BWTA 3FMRA 3IU9A 1WBQA 5JI6A 3PKCA 4IKTA 2Q92A 2BB7A 2DFIA 2IW2A 3PKEA 1CHMA 1BOAA 3BIPA 3IU8A 1PV9A 2BN7A 2EA2A 2GZ5A 3IG4A 5CLSA 2GGBA 1YJ3A 2P99A 3BIQA 5JHUA 4A6WA 1XGNA 1N51A 1Y1NA 5CIKA 4U6JA 1XGMA 4FLLA 2BWUA 4RZYA 4R60A 2Q95A 4IKUA 5CNXA 3CB6A 2GG0A 2GA2A 3MATA 3MR1A 2OAZA 3FMQA 5E5BA 5D6EA 1BN5A 2GU7A 4ZWPA 4U6WA 3L24A 4S01A 2ZSGA 2BHBA 1B6AA 2EA4A 4U71A 1R5HA 4FLJA 1YW9A 1WL6A 2Q8KA 4A6VA 1C27A 1WKMA 2GG9A 2Q93A 3Q6DA 4IKSA 3PKDA 1W2MA 1MATA 4S2TP 1QZYA 1C23A 1YVMA 4U6CA 2BHAA 4FKCA 3TAVA 2BWWA 5CDVA 1XGSA 2EVMA 5D6FA 2BWYA 1WN1A 2BHCA 2V3ZA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4RZZ A;  5CDL A;  1QXW A;  1YW8 A;  1B59 A;  1O0X A;  1R5G A;  4FLK A;  4IKR A;  4OOK A;  4U75 A;  2GG5 A;  4B28 A;  4U70 A;  1WL9 A;  2GG7 A;  2GGC A;  1KQ9 A;  2GU6 A;  4U73 A;  4U6E A;  4FLI A;  3MX6 A;  2B3K A;  2Q94 A;  4U69 A;  2BHD A;  2P98 A;  4Z7M A;  4PV4 A;  2GG8 A;  2NQ7 A;  1R58 A;  4IF7 A;  4PNC A;  3D27 A;  3CB5 A;  1JAW A;  4FUK A;  1A16 A;  3PKA A;  1C24 A;  4IU6 A;  2GTX A;  3FM3 A;  1QXY A;  4ZWU A;  1C21 A;  4QR8 A;  2B3H A;  1YW7 A;  3PKB A;  2Q96 A;  1QXZ A;  2GU4 A;  4ZWO A;  2BH3 A;  4U1B A;  2ADU A;  2BWS A;  3S6B A;  1M35 A;  1KP0 A;  3RVA A;  4S00 A;  2NQ6 A;  2GG2 A;  5CDE A;  2BWX A;  3L7G A;  5FCH A;  4MAT A;  2MAT A;  3ROR A;  5CE6 A;  3BIT A;  2OKN A;  1W7V A;  4IDY A;  4ZNG A;  2G6P A;  2P9A A;  2EVC A;  3TB5 A;  4EGE A;  1KQ0 A;  2EVO A;  4KM3 A;  3CTZ A;  4U76 A;  4IPA A;  4IEC A;  1WLR A;  1C22 A;  4FO7 A;  2V6C A;  1XGO A;  2V3Y A;  4JUQ A;  5JFR A;  2GU5 A;  1XNZ A;  2BWV A;  4FO8 A;  1WY2 A;  3IU7 A;  2V3X A;  4HXX A;  4S2R P;  5FCF A;  2B3L A;  2GG3 A;  2HOW A;  4RGZ 1;  4U6Z A;  2BWT A;  3FMR A;  3IU9 A;  1WBQ A;  5JI6 A;  3PKC A;  4IKT A;  2Q92 A;  2BB7 A;  2DFI A;  2IW2 A;  3PKE A;  1CHM A;  1BOA A;  3BIP A;  3IU8 A;  1PV9 A;  2BN7 A;  2EA2 A;  2GZ5 A;  3IG4 A;  5CLS A;  2GGB A;  1YJ3 A;  2P99 A;  3BIQ A;  5JHU A;  4A6W A;  1XGN A;  1N51 A;  1Y1N A;  5CIK A;  4U6J A;  1XGM A;  4FLL A;  2BWU A;  4RZY A;  4R60 A;  2Q95 A;  4IKU A;  5CNX A;  3CB6 A;  2GG0 A;  2GA2 A;  3MAT A;  3MR1 A;  2OAZ A;  3FMQ A;  5E5B A;  5D6E A;  1BN5 A;  2GU7 A;  4ZWP A;  4U6W A;  3L24 A;  4S01 A;  2ZSG A;  2BHB A;  1B6A A;  2EA4 A;  4U71 A;  1R5H A;  4FLJ A;  1YW9 A;  1WL6 A;  2Q8K A;  4A6V A;  1C27 A;  1WKM A;  2GG9 A;  2Q93 A;  3Q6D A;  4IKS A;  3PKD A;  1W2M A;  1MAT A;  4S2T P;  1QZY A;  1C23 A;  1YVM A;  4U6C A;  2BHA A;  4FKC A;  3TAV A;  2BWW A;  5CDV A;  1XGS A;  2EVM A;  5D6F A;  2BWY A;  1WN1 A;  2BHC A;  2V3Z A; 
#chains in the Genus database with same CATH topology
 4RZZ A;  5CDL A;  1QXW A;  1YW8 A;  1B59 A;  1O0X A;  1R5G A;  4FLK A;  4IKR A;  4OOK A;  4U75 A;  2GG5 A;  4B28 A;  4U70 A;  1WL9 A;  2GG7 A;  2GGC A;  1KQ9 A;  2GU6 A;  4U73 A;  4U6E A;  4FLI A;  3MX6 A;  2B3K A;  2Q94 A;  4U69 A;  2BHD A;  2P98 A;  4Z7M A;  4PV4 A;  2GG8 A;  2NQ7 A;  1R58 A;  4IF7 A;  4PNC A;  3D27 A;  3CB5 A;  1JAW A;  4FUK A;  1A16 A;  3PKA A;  1C24 A;  4IU6 A;  2GTX A;  3FM3 A;  1QXY A;  4ZWU A;  1C21 A;  4QR8 A;  2B3H A;  1YW7 A;  3PKB A;  2Q96 A;  1QXZ A;  2GU4 A;  4ZWO A;  2BH3 A;  4U1B A;  2ADU A;  2BWS A;  3S6B A;  1M35 A;  1KP0 A;  3RVA A;  4S00 A;  2NQ6 A;  2GG2 A;  5CDE A;  2BWX A;  3L7G A;  5FCH A;  4MAT A;  2MAT A;  3ROR A;  5CE6 A;  3BIT A;  2OKN A;  1W7V A;  4IDY A;  4ZNG A;  2G6P A;  2P9A A;  2EVC A;  3TB5 A;  4EGE A;  1KQ0 A;  2EVO A;  4KM3 A;  3CTZ A;  4U76 A;  4IPA A;  4IEC A;  1WLR A;  1C22 A;  4FO7 A;  2V6C A;  1XGO A;  2V3Y A;  4JUQ A;  5JFR A;  2GU5 A;  1XNZ A;  2BWV A;  4FO8 A;  1WY2 A;  3IU7 A;  2V3X A;  4HXX A;  4S2R P;  5FCF A;  2B3L A;  2GG3 A;  2HOW A;  4RGZ 1;  4U6Z A;  2BWT A;  3FMR A;  3IU9 A;  1WBQ A;  5JI6 A;  3PKC A;  4IKT A;  2Q92 A;  2BB7 A;  2DFI A;  2IW2 A;  3PKE A;  1CHM A;  1BOA A;  3BIP A;  3IU8 A;  1PV9 A;  2BN7 A;  2EA2 A;  2GZ5 A;  3IG4 A;  5CLS A;  2GGB A;  1YJ3 A;  2P99 A;  3BIQ A;  5JHU A;  4A6W A;  1XGN A;  1N51 A;  1Y1N A;  5CIK A;  4U6J A;  1XGM A;  4FLL A;  2BWU A;  4RZY A;  4R60 A;  2Q95 A;  4IKU A;  5CNX A;  3CB6 A;  2GG0 A;  2GA2 A;  3MAT A;  3MR1 A;  2OAZ A;  3FMQ A;  5E5B A;  5D6E A;  1BN5 A;  2GU7 A;  4ZWP A;  4U6W A;  3L24 A;  4S01 A;  2ZSG A;  2BHB A;  1B6A A;  2EA4 A;  4U71 A;  1R5H A;  4FLJ A;  1YW9 A;  1WL6 A;  2Q8K A;  4A6V A;  1C27 A;  1WKM A;  2GG9 A;  2Q93 A;  3Q6D A;  4IKS A;  3PKD A;  1W2M A;  1MAT A;  4S2T P;  1QZY A;  1C23 A;  1YVM A;  4U6C A;  2BHA A;  4FKC A;  3TAV A;  2BWW A;  5CDV A;  1XGS A;  2EVM A;  5D6F A;  2BWY A;  1WN1 A;  2BHC A;  2V3Z A; 
#chains in the Genus database with same CATH homology
 4RZZ A;  5CDL A;  1QXW A;  1YW8 A;  1B59 A;  1O0X A;  1R5G A;  4FLK A;  4IKR A;  4OOK A;  4U75 A;  2GG5 A;  4B28 A;  4U70 A;  1WL9 A;  2GG7 A;  2GGC A;  1KQ9 A;  2GU6 A;  4U73 A;  4U6E A;  4FLI A;  3MX6 A;  2B3K A;  2Q94 A;  4U69 A;  2BHD A;  2P98 A;  4Z7M A;  4PV4 A;  2GG8 A;  2NQ7 A;  1R58 A;  4IF7 A;  4PNC A;  3D27 A;  3CB5 A;  1JAW A;  4FUK A;  1A16 A;  3PKA A;  1C24 A;  4IU6 A;  2GTX A;  3FM3 A;  1QXY A;  4ZWU A;  1C21 A;  4QR8 A;  2B3H A;  1YW7 A;  3PKB A;  2Q96 A;  1QXZ A;  2GU4 A;  4ZWO A;  2BH3 A;  4U1B A;  2ADU A;  2BWS A;  3S6B A;  1M35 A;  1KP0 A;  3RVA A;  4S00 A;  2NQ6 A;  2GG2 A;  5CDE A;  2BWX A;  3L7G A;  5FCH A;  4MAT A;  2MAT A;  3ROR A;  5CE6 A;  3BIT A;  2OKN A;  1W7V A;  4IDY A;  4ZNG A;  2G6P A;  2P9A A;  2EVC A;  3TB5 A;  4EGE A;  1KQ0 A;  2EVO A;  4KM3 A;  3CTZ A;  4U76 A;  4IPA A;  4IEC A;  1WLR A;  1C22 A;  4FO7 A;  2V6C A;  1XGO A;  2V3Y A;  4JUQ A;  5JFR A;  2GU5 A;  1XNZ A;  2BWV A;  4FO8 A;  1WY2 A;  3IU7 A;  2V3X A;  4HXX A;  4S2R P;  5FCF A;  2B3L A;  2GG3 A;  2HOW A;  4RGZ 1;  4U6Z A;  2BWT A;  3FMR A;  3IU9 A;  1WBQ A;  5JI6 A;  3PKC A;  4IKT A;  2Q92 A;  2BB7 A;  2DFI A;  2IW2 A;  3PKE A;  1CHM A;  1BOA A;  3BIP A;  3IU8 A;  1PV9 A;  2BN7 A;  2EA2 A;  2GZ5 A;  3IG4 A;  5CLS A;  2GGB A;  1YJ3 A;  2P99 A;  3BIQ A;  5JHU A;  4A6W A;  1XGN A;  1N51 A;  1Y1N A;  5CIK A;  4U6J A;  1XGM A;  4FLL A;  2BWU A;  4RZY A;  4R60 A;  2Q95 A;  4IKU A;  5CNX A;  3CB6 A;  2GG0 A;  2GA2 A;  3MAT A;  3MR1 A;  2OAZ A;  3FMQ A;  5E5B A;  5D6E A;  1BN5 A;  2GU7 A;  4ZWP A;  4U6W A;  3L24 A;  4S01 A;  2ZSG A;  2BHB A;  1B6A A;  2EA4 A;  4U71 A;  1R5H A;  4FLJ A;  1YW9 A;  1WL6 A;  2Q8K A;  4A6V A;  1C27 A;  1WKM A;  2GG9 A;  2Q93 A;  3Q6D A;  4IKS A;  3PKD A;  1W2M A;  1MAT A;  4S2T P;  1QZY A;  1C23 A;  1YVM A;  4U6C A;  2BHA A;  4FKC A;  3TAV A;  2BWW A;  5CDV A;  1XGS A;  2EVM A;  5D6F A;  2BWY A;  1WN1 A;  2BHC A;  2V3Z A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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