4U76A

Hsmetap (f309m) holo form
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u76A00
1KP0A 4RZYA 1XNZA 2BWSA 4IF7A 3BITA 4U6ZA 1QXZA 4HXXA 4R60A 2GTXA 3D27A 5E5BA 3BIPA 2GU6A 1QXWA 1WL9A 4U1BA 2V3ZA 1W2MA 4A6VA 3TB5A 4S2RP 4FLJA 4ZWOA 1C21A 4FKCA 2Q8KA 1B59A 4IECA 1XGMA 5CE6A 4IU6A 4IKTA 2HOWA 2Q96A 2EVMA 4EGEA 2BHBA 4S01A 5CLSA 4FLIA 4PV4A 1XGSA 2GG2A 4IKSA 1B6AA 5FCHA 2GU5A 2P98A 4U6JA 1CHMA 2Q93A 4ZNGA 4B28A 1MATA 4OOKA 5JHUA 5CIKA 1O0XA 5JFRA 2BHDA 2BWYA 2B3HA 1WBQA 3TAVA 5CDVA 4FLLA 4RGZ1 5D6EA 4IDYA 4Z7MA 2NQ7A 2BHAA 2IW2A 1BN5A 1WY2A 3PKDA 2OKNA 2GG0A 2GGCA 1YW8A 3BIQA 4U6WA 1WL6A 4RZZA 2EA2A 3PKAA 2MATA 2P9AA 4FUKA 4U69A 2B3LA 4S2TP 2P99A 1C22A 1YJ3A 1KQ0A 2ZSGA 1R58A 4U71A 2V6CA 5CNXA 3L7GA 2DFIA 3RORA 5JI6A 2BHCA 1XGOA 4IKUA 1YW9A 3CB6A 4IPAA 1QZYA 4JUQA 1YW7A 2B3KA 4U70A 4ZWUA 3CTZA 4U75A 1W7VA 4U6EA 1BOAA 4FLKA 1M35A 2BN7A 1N51A 1QXYA 2BH3A 2EVCA 1R5GA 1WN1A 2G6PA 1R5HA 1PV9A 2EVOA 2GG9A 2GA2A 4PNCA 2GZ5A 2GG8A 2BWWA 2GU4A 2Q95A 2V3XA 2GU7A 4ZWPA 5CDLA 2V3YA 3L24A 4QR8A 5D6FA 2Q94A 2Q92A 3Q6DA 2BWUA 4FO8A 3PKBA 1Y1NA 1KQ9A 3FMQA 3S6BA 2OAZA 2BB7A 1C24A 4MATA 2ADUA 2GG5A 2BWTA 2GG7A 1WLRA 2GG3A 3MX6A 3FM3A 3IU7A 1C27A 1YVMA 2GGBA 3MATA 3MR1A 2BWVA 3IU9A 4IKRA 3FMRA 5FCFA 4S00A 1JAWA 3RVAA 1XGNA 3CB5A 4U76A 4KM3A 2NQ6A 1C23A 3PKCA 3PKEA 4FO7A 2BWXA 5CDEA 4U6CA 1A16A 3IU8A 2EA4A 3IG4A 4U73A 4A6WA 1WKMA
chains in the Genus database with same CATH superfamily
1KP0A 4RZYA 1XNZA 2BWSA 4IF7A 3BITA 4U6ZA 1QXZA 4HXXA 4R60A 2GTXA 3D27A 5E5BA 3BIPA 2GU6A 1QXWA 1WL9A 4U1BA 2V3ZA 1W2MA 4A6VA 3TB5A 4S2RP 4FLJA 4ZWOA 1C21A 4FKCA 2Q8KA 1B59A 4IECA 1XGMA 5CE6A 4IU6A 4IKTA 2HOWA 2Q96A 2EVMA 4EGEA 2BHBA 4S01A 5CLSA 4FLIA 4PV4A 1XGSA 2GG2A 4IKSA 1B6AA 5FCHA 2GU5A 2P98A 4U6JA 1CHMA 2Q93A 4ZNGA 4B28A 1MATA 4OOKA 5JHUA 5CIKA 1O0XA 5JFRA 2BHDA 2BWYA 2B3HA 1WBQA 3TAVA 5CDVA 4FLLA 4RGZ1 5D6EA 4IDYA 4Z7MA 2NQ7A 2BHAA 2IW2A 1BN5A 1WY2A 3PKDA 2OKNA 2GG0A 2GGCA 1YW8A 3BIQA 4U6WA 1WL6A 4RZZA 2EA2A 3PKAA 2MATA 2P9AA 4FUKA 4U69A 2B3LA 4S2TP 2P99A 1C22A 1YJ3A 1KQ0A 2ZSGA 1R58A 4U71A 2V6CA 5CNXA 3L7GA 2DFIA 3RORA 5JI6A 2BHCA 1XGOA 4IKUA 1YW9A 3CB6A 4IPAA 1QZYA 4JUQA 1YW7A 2B3KA 4U70A 4ZWUA 3CTZA 4U75A 1W7VA 4U6EA 1BOAA 4FLKA 1M35A 2BN7A 1N51A 1QXYA 2BH3A 2EVCA 1R5GA 1WN1A 2G6PA 1R5HA 1PV9A 2EVOA 2GG9A 2GA2A 4PNCA 2GZ5A 2GG8A 2BWWA 2GU4A 2Q95A 2V3XA 2GU7A 4ZWPA 5CDLA 2V3YA 3L24A 4QR8A 5D6FA 2Q94A 2Q92A 3Q6DA 2BWUA 4FO8A 3PKBA 1Y1NA 1KQ9A 3FMQA 3S6BA 2OAZA 2BB7A 1C24A 4MATA 2ADUA 2GG5A 2BWTA 2GG7A 1WLRA 2GG3A 3MX6A 3FM3A 3IU7A 1C27A 1YVMA 2GGBA 3MATA 3MR1A 2BWVA 3IU9A 4IKRA 3FMRA 5FCFA 4S00A 1JAWA 3RVAA 1XGNA 3CB5A 4U76A 4KM3A 2NQ6A 1C23A 3PKCA 3PKEA 4FO7A 2BWXA 5CDEA 4U6CA 1A16A 3IU8A 2EA4A 3IG4A 4U73A 4A6WA 1WKMA
chains in the Genus database with same CATH topology
1KP0A 4RZYA 1XNZA 2BWSA 4IF7A 3BITA 4U6ZA 1QXZA 4HXXA 4R60A 2GTXA 3D27A 5E5BA 3BIPA 2GU6A 1QXWA 1WL9A 4U1BA 2V3ZA 1W2MA 4A6VA 3TB5A 4S2RP 4FLJA 4ZWOA 1C21A 4FKCA 2Q8KA 1B59A 4IECA 1XGMA 5CE6A 4IU6A 4IKTA 2HOWA 2Q96A 2EVMA 4EGEA 2BHBA 4S01A 5CLSA 4FLIA 4PV4A 1XGSA 2GG2A 4IKSA 1B6AA 5FCHA 2GU5A 2P98A 4U6JA 1CHMA 2Q93A 4ZNGA 4B28A 1MATA 4OOKA 5JHUA 5CIKA 1O0XA 5JFRA 2BHDA 2BWYA 2B3HA 1WBQA 3TAVA 5CDVA 4FLLA 4RGZ1 5D6EA 4IDYA 4Z7MA 2NQ7A 2BHAA 2IW2A 1BN5A 1WY2A 3PKDA 2OKNA 2GG0A 2GGCA 1YW8A 3BIQA 4U6WA 1WL6A 4RZZA 2EA2A 3PKAA 2MATA 2P9AA 4FUKA 4U69A 2B3LA 4S2TP 2P99A 1C22A 1YJ3A 1KQ0A 2ZSGA 1R58A 4U71A 2V6CA 5CNXA 3L7GA 2DFIA 3RORA 5JI6A 2BHCA 1XGOA 4IKUA 1YW9A 3CB6A 4IPAA 1QZYA 4JUQA 1YW7A 2B3KA 4U70A 4ZWUA 3CTZA 4U75A 1W7VA 4U6EA 1BOAA 4FLKA 1M35A 2BN7A 1N51A 1QXYA 2BH3A 2EVCA 1R5GA 1WN1A 2G6PA 1R5HA 1PV9A 2EVOA 2GG9A 2GA2A 4PNCA 2GZ5A 2GG8A 2BWWA 2GU4A 2Q95A 2V3XA 2GU7A 4ZWPA 5CDLA 2V3YA 3L24A 4QR8A 5D6FA 2Q94A 2Q92A 3Q6DA 2BWUA 4FO8A 3PKBA 1Y1NA 1KQ9A 3FMQA 3S6BA 2OAZA 2BB7A 1C24A 4MATA 2ADUA 2GG5A 2BWTA 2GG7A 1WLRA 2GG3A 3MX6A 3FM3A 3IU7A 1C27A 1YVMA 2GGBA 3MATA 3MR1A 2BWVA 3IU9A 4IKRA 3FMRA 5FCFA 4S00A 1JAWA 3RVAA 1XGNA 3CB5A 4U76A 4KM3A 2NQ6A 1C23A 3PKCA 3PKEA 4FO7A 2BWXA 5CDEA 4U6CA 1A16A 3IU8A 2EA4A 3IG4A 4U73A 4A6WA 1WKMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KP0 A;  4RZY A;  1XNZ A;  2BWS A;  4IF7 A;  3BIT A;  4U6Z A;  1QXZ A;  4HXX A;  4R60 A;  2GTX A;  3D27 A;  5E5B A;  3BIP A;  2GU6 A;  1QXW A;  1WL9 A;  4U1B A;  2V3Z A;  1W2M A;  4A6V A;  3TB5 A;  4S2R P;  4FLJ A;  4ZWO A;  1C21 A;  4FKC A;  2Q8K A;  1B59 A;  4IEC A;  1XGM A;  5CE6 A;  4IU6 A;  4IKT A;  2HOW A;  2Q96 A;  2EVM A;  4EGE A;  2BHB A;  4S01 A;  5CLS A;  4FLI A;  4PV4 A;  1XGS A;  2GG2 A;  4IKS A;  1B6A A;  5FCH A;  2GU5 A;  2P98 A;  4U6J A;  1CHM A;  2Q93 A;  4ZNG A;  4B28 A;  1MAT A;  4OOK A;  5JHU A;  5CIK A;  1O0X A;  5JFR A;  2BHD A;  2BWY A;  2B3H A;  1WBQ A;  3TAV A;  5CDV A;  4FLL A;  4RGZ 1;  5D6E A;  4IDY A;  4Z7M A;  2NQ7 A;  2BHA A;  2IW2 A;  1BN5 A;  1WY2 A;  3PKD A;  2OKN A;  2GG0 A;  2GGC A;  1YW8 A;  3BIQ A;  4U6W A;  1WL6 A;  4RZZ A;  2EA2 A;  3PKA A;  2MAT A;  2P9A A;  4FUK A;  4U69 A;  2B3L A;  4S2T P;  2P99 A;  1C22 A;  1YJ3 A;  1KQ0 A;  2ZSG A;  1R58 A;  4U71 A;  2V6C A;  5CNX A;  3L7G A;  2DFI A;  3ROR A;  5JI6 A;  2BHC A;  1XGO A;  4IKU A;  1YW9 A;  3CB6 A;  4IPA A;  1QZY A;  4JUQ A;  1YW7 A;  2B3K A;  4U70 A;  4ZWU A;  3CTZ A;  4U75 A;  1W7V A;  4U6E A;  1BOA A;  4FLK A;  1M35 A;  2BN7 A;  1N51 A;  1QXY A;  2BH3 A;  2EVC A;  1R5G A;  1WN1 A;  2G6P A;  1R5H A;  1PV9 A;  2EVO A;  2GG9 A;  2GA2 A;  4PNC A;  2GZ5 A;  2GG8 A;  2BWW A;  2GU4 A;  2Q95 A;  2V3X A;  2GU7 A;  4ZWP A;  5CDL A;  2V3Y A;  3L24 A;  4QR8 A;  5D6F A;  2Q94 A;  2Q92 A;  3Q6D A;  2BWU A;  4FO8 A;  3PKB A;  1Y1N A;  1KQ9 A;  3FMQ A;  3S6B A;  2OAZ A;  2BB7 A;  1C24 A;  4MAT A;  2ADU A;  2GG5 A;  2BWT A;  2GG7 A;  1WLR A;  2GG3 A;  3MX6 A;  3FM3 A;  3IU7 A;  1C27 A;  1YVM A;  2GGB A;  3MAT A;  3MR1 A;  2BWV A;  3IU9 A;  4IKR A;  3FMR A;  5FCF A;  4S00 A;  1JAW A;  3RVA A;  1XGN A;  3CB5 A;  4U76 A;  4KM3 A;  2NQ6 A;  1C23 A;  3PKC A;  3PKE A;  4FO7 A;  2BWX A;  5CDE A;  4U6C A;  1A16 A;  3IU8 A;  2EA4 A;  3IG4 A;  4U73 A;  4A6W A;  1WKM A; 
#chains in the Genus database with same CATH topology
 1KP0 A;  4RZY A;  1XNZ A;  2BWS A;  4IF7 A;  3BIT A;  4U6Z A;  1QXZ A;  4HXX A;  4R60 A;  2GTX A;  3D27 A;  5E5B A;  3BIP A;  2GU6 A;  1QXW A;  1WL9 A;  4U1B A;  2V3Z A;  1W2M A;  4A6V A;  3TB5 A;  4S2R P;  4FLJ A;  4ZWO A;  1C21 A;  4FKC A;  2Q8K A;  1B59 A;  4IEC A;  1XGM A;  5CE6 A;  4IU6 A;  4IKT A;  2HOW A;  2Q96 A;  2EVM A;  4EGE A;  2BHB A;  4S01 A;  5CLS A;  4FLI A;  4PV4 A;  1XGS A;  2GG2 A;  4IKS A;  1B6A A;  5FCH A;  2GU5 A;  2P98 A;  4U6J A;  1CHM A;  2Q93 A;  4ZNG A;  4B28 A;  1MAT A;  4OOK A;  5JHU A;  5CIK A;  1O0X A;  5JFR A;  2BHD A;  2BWY A;  2B3H A;  1WBQ A;  3TAV A;  5CDV A;  4FLL A;  4RGZ 1;  5D6E A;  4IDY A;  4Z7M A;  2NQ7 A;  2BHA A;  2IW2 A;  1BN5 A;  1WY2 A;  3PKD A;  2OKN A;  2GG0 A;  2GGC A;  1YW8 A;  3BIQ A;  4U6W A;  1WL6 A;  4RZZ A;  2EA2 A;  3PKA A;  2MAT A;  2P9A A;  4FUK A;  4U69 A;  2B3L A;  4S2T P;  2P99 A;  1C22 A;  1YJ3 A;  1KQ0 A;  2ZSG A;  1R58 A;  4U71 A;  2V6C A;  5CNX A;  3L7G A;  2DFI A;  3ROR A;  5JI6 A;  2BHC A;  1XGO A;  4IKU A;  1YW9 A;  3CB6 A;  4IPA A;  1QZY A;  4JUQ A;  1YW7 A;  2B3K A;  4U70 A;  4ZWU A;  3CTZ A;  4U75 A;  1W7V A;  4U6E A;  1BOA A;  4FLK A;  1M35 A;  2BN7 A;  1N51 A;  1QXY A;  2BH3 A;  2EVC A;  1R5G A;  1WN1 A;  2G6P A;  1R5H A;  1PV9 A;  2EVO A;  2GG9 A;  2GA2 A;  4PNC A;  2GZ5 A;  2GG8 A;  2BWW A;  2GU4 A;  2Q95 A;  2V3X A;  2GU7 A;  4ZWP A;  5CDL A;  2V3Y A;  3L24 A;  4QR8 A;  5D6F A;  2Q94 A;  2Q92 A;  3Q6D A;  2BWU A;  4FO8 A;  3PKB A;  1Y1N A;  1KQ9 A;  3FMQ A;  3S6B A;  2OAZ A;  2BB7 A;  1C24 A;  4MAT A;  2ADU A;  2GG5 A;  2BWT A;  2GG7 A;  1WLR A;  2GG3 A;  3MX6 A;  3FM3 A;  3IU7 A;  1C27 A;  1YVM A;  2GGB A;  3MAT A;  3MR1 A;  2BWV A;  3IU9 A;  4IKR A;  3FMR A;  5FCF A;  4S00 A;  1JAW A;  3RVA A;  1XGN A;  3CB5 A;  4U76 A;  4KM3 A;  2NQ6 A;  1C23 A;  3PKC A;  3PKE A;  4FO7 A;  2BWX A;  5CDE A;  4U6C A;  1A16 A;  3IU8 A;  2EA4 A;  3IG4 A;  4U73 A;  4A6W A;  1WKM A; 
#chains in the Genus database with same CATH homology
 1KP0 A;  4RZY A;  1XNZ A;  2BWS A;  4IF7 A;  3BIT A;  4U6Z A;  1QXZ A;  4HXX A;  4R60 A;  2GTX A;  3D27 A;  5E5B A;  3BIP A;  2GU6 A;  1QXW A;  1WL9 A;  4U1B A;  2V3Z A;  1W2M A;  4A6V A;  3TB5 A;  4S2R P;  4FLJ A;  4ZWO A;  1C21 A;  4FKC A;  2Q8K A;  1B59 A;  4IEC A;  1XGM A;  5CE6 A;  4IU6 A;  4IKT A;  2HOW A;  2Q96 A;  2EVM A;  4EGE A;  2BHB A;  4S01 A;  5CLS A;  4FLI A;  4PV4 A;  1XGS A;  2GG2 A;  4IKS A;  1B6A A;  5FCH A;  2GU5 A;  2P98 A;  4U6J A;  1CHM A;  2Q93 A;  4ZNG A;  4B28 A;  1MAT A;  4OOK A;  5JHU A;  5CIK A;  1O0X A;  5JFR A;  2BHD A;  2BWY A;  2B3H A;  1WBQ A;  3TAV A;  5CDV A;  4FLL A;  4RGZ 1;  5D6E A;  4IDY A;  4Z7M A;  2NQ7 A;  2BHA A;  2IW2 A;  1BN5 A;  1WY2 A;  3PKD A;  2OKN A;  2GG0 A;  2GGC A;  1YW8 A;  3BIQ A;  4U6W A;  1WL6 A;  4RZZ A;  2EA2 A;  3PKA A;  2MAT A;  2P9A A;  4FUK A;  4U69 A;  2B3L A;  4S2T P;  2P99 A;  1C22 A;  1YJ3 A;  1KQ0 A;  2ZSG A;  1R58 A;  4U71 A;  2V6C A;  5CNX A;  3L7G A;  2DFI A;  3ROR A;  5JI6 A;  2BHC A;  1XGO A;  4IKU A;  1YW9 A;  3CB6 A;  4IPA A;  1QZY A;  4JUQ A;  1YW7 A;  2B3K A;  4U70 A;  4ZWU A;  3CTZ A;  4U75 A;  1W7V A;  4U6E A;  1BOA A;  4FLK A;  1M35 A;  2BN7 A;  1N51 A;  1QXY A;  2BH3 A;  2EVC A;  1R5G A;  1WN1 A;  2G6P A;  1R5H A;  1PV9 A;  2EVO A;  2GG9 A;  2GA2 A;  4PNC A;  2GZ5 A;  2GG8 A;  2BWW A;  2GU4 A;  2Q95 A;  2V3X A;  2GU7 A;  4ZWP A;  5CDL A;  2V3Y A;  3L24 A;  4QR8 A;  5D6F A;  2Q94 A;  2Q92 A;  3Q6D A;  2BWU A;  4FO8 A;  3PKB A;  1Y1N A;  1KQ9 A;  3FMQ A;  3S6B A;  2OAZ A;  2BB7 A;  1C24 A;  4MAT A;  2ADU A;  2GG5 A;  2BWT A;  2GG7 A;  1WLR A;  2GG3 A;  3MX6 A;  3FM3 A;  3IU7 A;  1C27 A;  1YVM A;  2GGB A;  3MAT A;  3MR1 A;  2BWV A;  3IU9 A;  4IKR A;  3FMR A;  5FCF A;  4S00 A;  1JAW A;  3RVA A;  1XGN A;  3CB5 A;  4U76 A;  4KM3 A;  2NQ6 A;  1C23 A;  3PKC A;  3PKE A;  4FO7 A;  2BWX A;  5CDE A;  4U6C A;  1A16 A;  3IU8 A;  2EA4 A;  3IG4 A;  4U73 A;  4A6W A;  1WKM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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