4IECA

Cys105 covalent modification by 2-hydroxyethyl disulfide in mycobacterium tuberculosis methionine aminopeptidase type 1c
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
280
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Methionine aminopeptidase 2
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 86
structure length 280
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4iecA01
3TB5A 4FLLA 2EVMA 2IW2A 1KP0A 3IU8A 3CB5A 3FMRA 4S2RP 5JI6A 1XNZA 2Q95A 2Q96A 2BWVA 4A6VA 2GU6A 4QR8A 4HXXA 4S01A 3PKAA 1M35A 3PKDA 4U1BA 2GG7A 2GU5A 2HOWA 4FUKA 5CIKA 1WY2A 4IKTA 2BHCA 3CB6A 4ZWOA 2Q92A 2GG3A 3MX6A 4IF7A 4IPAA 4PV4A 4RZYA 2MATA 4FLKA 4U6WA 2P99A 5CDVA 5JFRA 1JAWA 4EGEA 4R60A 5CNXA 1WL6A 1KQ9A 3D27A 5CLSA 1R5HA 1XGMA 2GGCA 4U76A 4ZNGA 3IU7A 2ADUA 1PV9A 1MATA 3L24A 4U73A 1QXWA 1QZYA 5E5BA 3PKEA 1W2MA 1BOAA 1C24A 2B3HA 2Q8KA 1WKMA 4S00A 3FMQA 5D6FA 2Q94A 4FLIA 4IKRA 1QXZA 5FCHA 2B3KA 2GZ5A 3BIPA 1B6AA 4ZWPA 1WL9A 2GG2A 2GGBA 1B59A 2BH3A 2GU4A 2V6CA 4U6CA 2OKNA 2BWUA 5D6EA 5CDLA 2BWWA 2GG8A 1WN1A 4KM3A 2EVOA 4RZZA 1YW8A 3MATA 1R5GA 1WLRA 2GU7A 4FO7A 2EA4A 3FM3A 5CDEA 4A6WA 5JHUA 1C23A 4U6JA 2BWYA 4IECA 2BHAA 3IU9A 2BHBA 1C22A 1C27A 1YVMA 4RGZ1 2B3LA 4PNCA 3RORA 2GG0A 4U6ZA 3S6BA 1YW7A 2P98A 2BB7A 2EA2A 4OOKA 2DFIA 2GA2A 2GG9A 2ZSGA 4IDYA 2V3ZA 1R58A 2V3XA 3Q6DA 4U70A 4U71A 2EVCA 2BHDA 4ZWUA 4IKUA 4FO8A 4U75A 2NQ6A 4Z7MA 5CE6A 4IKSA 3PKCA 1Y1NA 1YJ3A 4U6EA 1O0XA 1W7VA 1CHMA 2P9AA 3TAVA 2GG5A 3PKBA 2G6PA 2Q93A 4FLJA 3CTZA 4S2TP 4FKCA 3L7GA 1KQ0A 1WBQA 2GTXA 4MATA 2BWSA 2BWTA 4JUQA 4B28A 1XGNA 4U69A 1QXYA 1N51A 3IG4A 1C21A 4IU6A 5FCFA 1YW9A 1BN5A 1XGOA 2OAZA 3MR1A 2BWXA 3BITA 3RVAA 1A16A 2NQ7A 1XGSA 3BIQA 2BN7A 2V3YA
chains in the Genus database with same CATH superfamily
3TB5A 4FLLA 2EVMA 2IW2A 1KP0A 3IU8A 3CB5A 3FMRA 4S2RP 5JI6A 1XNZA 2Q95A 2Q96A 2BWVA 4A6VA 2GU6A 4QR8A 4HXXA 4S01A 3PKAA 1M35A 3PKDA 4U1BA 2GG7A 2GU5A 2HOWA 4FUKA 5CIKA 1WY2A 4IKTA 2BHCA 3CB6A 4ZWOA 2Q92A 2GG3A 3MX6A 4IF7A 4IPAA 4PV4A 4RZYA 2MATA 4FLKA 4U6WA 2P99A 5CDVA 5JFRA 1JAWA 4EGEA 4R60A 5CNXA 1WL6A 1KQ9A 3D27A 5CLSA 1R5HA 1XGMA 2GGCA 4U76A 4ZNGA 3IU7A 2ADUA 1PV9A 1MATA 3L24A 4U73A 1QXWA 1QZYA 5E5BA 3PKEA 1W2MA 1BOAA 1C24A 2B3HA 2Q8KA 1WKMA 4S00A 3FMQA 5D6FA 2Q94A 4FLIA 4IKRA 1QXZA 5FCHA 2B3KA 2GZ5A 3BIPA 1B6AA 4ZWPA 1WL9A 2GG2A 2GGBA 1B59A 2BH3A 2GU4A 2V6CA 4U6CA 2OKNA 2BWUA 5D6EA 5CDLA 2BWWA 2GG8A 1WN1A 4KM3A 2EVOA 4RZZA 1YW8A 3MATA 1R5GA 1WLRA 2GU7A 4FO7A 2EA4A 3FM3A 5CDEA 4A6WA 5JHUA 1C23A 4U6JA 2BWYA 4IECA 2BHAA 3IU9A 2BHBA 1C22A 1C27A 1YVMA 4RGZ1 2B3LA 4PNCA 3RORA 2GG0A 4U6ZA 3S6BA 1YW7A 2P98A 2BB7A 2EA2A 4OOKA 2DFIA 2GA2A 2GG9A 2ZSGA 4IDYA 2V3ZA 1R58A 2V3XA 3Q6DA 4U70A 4U71A 2EVCA 2BHDA 4ZWUA 4IKUA 4FO8A 4U75A 2NQ6A 4Z7MA 5CE6A 4IKSA 3PKCA 1Y1NA 1YJ3A 4U6EA 1O0XA 1W7VA 1CHMA 2P9AA 3TAVA 2GG5A 3PKBA 2G6PA 2Q93A 4FLJA 3CTZA 4S2TP 4FKCA 3L7GA 1KQ0A 1WBQA 2GTXA 4MATA 2BWSA 2BWTA 4JUQA 4B28A 1XGNA 4U69A 1QXYA 1N51A 3IG4A 1C21A 4IU6A 5FCFA 1YW9A 1BN5A 1XGOA 2OAZA 3MR1A 2BWXA 3BITA 3RVAA 1A16A 2NQ7A 1XGSA 3BIQA 2BN7A 2V3YA
chains in the Genus database with same CATH topology
3TB5A 4FLLA 2EVMA 2IW2A 1KP0A 3IU8A 3CB5A 3FMRA 4S2RP 5JI6A 1XNZA 2Q95A 2Q96A 2BWVA 4A6VA 2GU6A 4QR8A 4HXXA 4S01A 3PKAA 1M35A 3PKDA 4U1BA 2GG7A 2GU5A 2HOWA 4FUKA 5CIKA 1WY2A 4IKTA 2BHCA 3CB6A 4ZWOA 2Q92A 2GG3A 3MX6A 4IF7A 4IPAA 4PV4A 4RZYA 2MATA 4FLKA 4U6WA 2P99A 5CDVA 5JFRA 1JAWA 4EGEA 4R60A 5CNXA 1WL6A 1KQ9A 3D27A 5CLSA 1R5HA 1XGMA 2GGCA 4U76A 4ZNGA 3IU7A 2ADUA 1PV9A 1MATA 3L24A 4U73A 1QXWA 1QZYA 5E5BA 3PKEA 1W2MA 1BOAA 1C24A 2B3HA 2Q8KA 1WKMA 4S00A 3FMQA 5D6FA 2Q94A 4FLIA 4IKRA 1QXZA 5FCHA 2B3KA 2GZ5A 3BIPA 1B6AA 4ZWPA 1WL9A 2GG2A 2GGBA 1B59A 2BH3A 2GU4A 2V6CA 4U6CA 2OKNA 2BWUA 5D6EA 5CDLA 2BWWA 2GG8A 1WN1A 4KM3A 2EVOA 4RZZA 1YW8A 3MATA 1R5GA 1WLRA 2GU7A 4FO7A 2EA4A 3FM3A 5CDEA 4A6WA 5JHUA 1C23A 4U6JA 2BWYA 4IECA 2BHAA 3IU9A 2BHBA 1C22A 1C27A 1YVMA 4RGZ1 2B3LA 4PNCA 3RORA 2GG0A 4U6ZA 3S6BA 1YW7A 2P98A 2BB7A 2EA2A 4OOKA 2DFIA 2GA2A 2GG9A 2ZSGA 4IDYA 2V3ZA 1R58A 2V3XA 3Q6DA 4U70A 4U71A 2EVCA 2BHDA 4ZWUA 4IKUA 4FO8A 4U75A 2NQ6A 4Z7MA 5CE6A 4IKSA 3PKCA 1Y1NA 1YJ3A 4U6EA 1O0XA 1W7VA 1CHMA 2P9AA 3TAVA 2GG5A 3PKBA 2G6PA 2Q93A 4FLJA 3CTZA 4S2TP 4FKCA 3L7GA 1KQ0A 1WBQA 2GTXA 4MATA 2BWSA 2BWTA 4JUQA 4B28A 1XGNA 4U69A 1QXYA 1N51A 3IG4A 1C21A 4IU6A 5FCFA 1YW9A 1BN5A 1XGOA 2OAZA 3MR1A 2BWXA 3BITA 3RVAA 1A16A 2NQ7A 1XGSA 3BIQA 2BN7A 2V3YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TB5 A;  4FLL A;  2EVM A;  2IW2 A;  1KP0 A;  3IU8 A;  3CB5 A;  3FMR A;  4S2R P;  5JI6 A;  1XNZ A;  2Q95 A;  2Q96 A;  2BWV A;  4A6V A;  2GU6 A;  4QR8 A;  4HXX A;  4S01 A;  3PKA A;  1M35 A;  3PKD A;  4U1B A;  2GG7 A;  2GU5 A;  2HOW A;  4FUK A;  5CIK A;  1WY2 A;  4IKT A;  2BHC A;  3CB6 A;  4ZWO A;  2Q92 A;  2GG3 A;  3MX6 A;  4IF7 A;  4IPA A;  4PV4 A;  4RZY A;  2MAT A;  4FLK A;  4U6W A;  2P99 A;  5CDV A;  5JFR A;  1JAW A;  4EGE A;  4R60 A;  5CNX A;  1WL6 A;  1KQ9 A;  3D27 A;  5CLS A;  1R5H A;  1XGM A;  2GGC A;  4U76 A;  4ZNG A;  3IU7 A;  2ADU A;  1PV9 A;  1MAT A;  3L24 A;  4U73 A;  1QXW A;  1QZY A;  5E5B A;  3PKE A;  1W2M A;  1BOA A;  1C24 A;  2B3H A;  2Q8K A;  1WKM A;  4S00 A;  3FMQ A;  5D6F A;  2Q94 A;  4FLI A;  4IKR A;  1QXZ A;  5FCH A;  2B3K A;  2GZ5 A;  3BIP A;  1B6A A;  4ZWP A;  1WL9 A;  2GG2 A;  2GGB A;  1B59 A;  2BH3 A;  2GU4 A;  2V6C A;  4U6C A;  2OKN A;  2BWU A;  5D6E A;  5CDL A;  2BWW A;  2GG8 A;  1WN1 A;  4KM3 A;  2EVO A;  4RZZ A;  1YW8 A;  3MAT A;  1R5G A;  1WLR A;  2GU7 A;  4FO7 A;  2EA4 A;  3FM3 A;  5CDE A;  4A6W A;  5JHU A;  1C23 A;  4U6J A;  2BWY A;  4IEC A;  2BHA A;  3IU9 A;  2BHB A;  1C22 A;  1C27 A;  1YVM A;  4RGZ 1;  2B3L A;  4PNC A;  3ROR A;  2GG0 A;  4U6Z A;  3S6B A;  1YW7 A;  2P98 A;  2BB7 A;  2EA2 A;  4OOK A;  2DFI A;  2GA2 A;  2GG9 A;  2ZSG A;  4IDY A;  2V3Z A;  1R58 A;  2V3X A;  3Q6D A;  4U70 A;  4U71 A;  2EVC A;  2BHD A;  4ZWU A;  4IKU A;  4FO8 A;  4U75 A;  2NQ6 A;  4Z7M A;  5CE6 A;  4IKS A;  3PKC A;  1Y1N A;  1YJ3 A;  4U6E A;  1O0X A;  1W7V A;  1CHM A;  2P9A A;  3TAV A;  2GG5 A;  3PKB A;  2G6P A;  2Q93 A;  4FLJ A;  3CTZ A;  4S2T P;  4FKC A;  3L7G A;  1KQ0 A;  1WBQ A;  2GTX A;  4MAT A;  2BWS A;  2BWT A;  4JUQ A;  4B28 A;  1XGN A;  4U69 A;  1QXY A;  1N51 A;  3IG4 A;  1C21 A;  4IU6 A;  5FCF A;  1YW9 A;  1BN5 A;  1XGO A;  2OAZ A;  3MR1 A;  2BWX A;  3BIT A;  3RVA A;  1A16 A;  2NQ7 A;  1XGS A;  3BIQ A;  2BN7 A;  2V3Y A; 
#chains in the Genus database with same CATH topology
 3TB5 A;  4FLL A;  2EVM A;  2IW2 A;  1KP0 A;  3IU8 A;  3CB5 A;  3FMR A;  4S2R P;  5JI6 A;  1XNZ A;  2Q95 A;  2Q96 A;  2BWV A;  4A6V A;  2GU6 A;  4QR8 A;  4HXX A;  4S01 A;  3PKA A;  1M35 A;  3PKD A;  4U1B A;  2GG7 A;  2GU5 A;  2HOW A;  4FUK A;  5CIK A;  1WY2 A;  4IKT A;  2BHC A;  3CB6 A;  4ZWO A;  2Q92 A;  2GG3 A;  3MX6 A;  4IF7 A;  4IPA A;  4PV4 A;  4RZY A;  2MAT A;  4FLK A;  4U6W A;  2P99 A;  5CDV A;  5JFR A;  1JAW A;  4EGE A;  4R60 A;  5CNX A;  1WL6 A;  1KQ9 A;  3D27 A;  5CLS A;  1R5H A;  1XGM A;  2GGC A;  4U76 A;  4ZNG A;  3IU7 A;  2ADU A;  1PV9 A;  1MAT A;  3L24 A;  4U73 A;  1QXW A;  1QZY A;  5E5B A;  3PKE A;  1W2M A;  1BOA A;  1C24 A;  2B3H A;  2Q8K A;  1WKM A;  4S00 A;  3FMQ A;  5D6F A;  2Q94 A;  4FLI A;  4IKR A;  1QXZ A;  5FCH A;  2B3K A;  2GZ5 A;  3BIP A;  1B6A A;  4ZWP A;  1WL9 A;  2GG2 A;  2GGB A;  1B59 A;  2BH3 A;  2GU4 A;  2V6C A;  4U6C A;  2OKN A;  2BWU A;  5D6E A;  5CDL A;  2BWW A;  2GG8 A;  1WN1 A;  4KM3 A;  2EVO A;  4RZZ A;  1YW8 A;  3MAT A;  1R5G A;  1WLR A;  2GU7 A;  4FO7 A;  2EA4 A;  3FM3 A;  5CDE A;  4A6W A;  5JHU A;  1C23 A;  4U6J A;  2BWY A;  4IEC A;  2BHA A;  3IU9 A;  2BHB A;  1C22 A;  1C27 A;  1YVM A;  4RGZ 1;  2B3L A;  4PNC A;  3ROR A;  2GG0 A;  4U6Z A;  3S6B A;  1YW7 A;  2P98 A;  2BB7 A;  2EA2 A;  4OOK A;  2DFI A;  2GA2 A;  2GG9 A;  2ZSG A;  4IDY A;  2V3Z A;  1R58 A;  2V3X A;  3Q6D A;  4U70 A;  4U71 A;  2EVC A;  2BHD A;  4ZWU A;  4IKU A;  4FO8 A;  4U75 A;  2NQ6 A;  4Z7M A;  5CE6 A;  4IKS A;  3PKC A;  1Y1N A;  1YJ3 A;  4U6E A;  1O0X A;  1W7V A;  1CHM A;  2P9A A;  3TAV A;  2GG5 A;  3PKB A;  2G6P A;  2Q93 A;  4FLJ A;  3CTZ A;  4S2T P;  4FKC A;  3L7G A;  1KQ0 A;  1WBQ A;  2GTX A;  4MAT A;  2BWS A;  2BWT A;  4JUQ A;  4B28 A;  1XGN A;  4U69 A;  1QXY A;  1N51 A;  3IG4 A;  1C21 A;  4IU6 A;  5FCF A;  1YW9 A;  1BN5 A;  1XGO A;  2OAZ A;  3MR1 A;  2BWX A;  3BIT A;  3RVA A;  1A16 A;  2NQ7 A;  1XGS A;  3BIQ A;  2BN7 A;  2V3Y A; 
#chains in the Genus database with same CATH homology
 3TB5 A;  4FLL A;  2EVM A;  2IW2 A;  1KP0 A;  3IU8 A;  3CB5 A;  3FMR A;  4S2R P;  5JI6 A;  1XNZ A;  2Q95 A;  2Q96 A;  2BWV A;  4A6V A;  2GU6 A;  4QR8 A;  4HXX A;  4S01 A;  3PKA A;  1M35 A;  3PKD A;  4U1B A;  2GG7 A;  2GU5 A;  2HOW A;  4FUK A;  5CIK A;  1WY2 A;  4IKT A;  2BHC A;  3CB6 A;  4ZWO A;  2Q92 A;  2GG3 A;  3MX6 A;  4IF7 A;  4IPA A;  4PV4 A;  4RZY A;  2MAT A;  4FLK A;  4U6W A;  2P99 A;  5CDV A;  5JFR A;  1JAW A;  4EGE A;  4R60 A;  5CNX A;  1WL6 A;  1KQ9 A;  3D27 A;  5CLS A;  1R5H A;  1XGM A;  2GGC A;  4U76 A;  4ZNG A;  3IU7 A;  2ADU A;  1PV9 A;  1MAT A;  3L24 A;  4U73 A;  1QXW A;  1QZY A;  5E5B A;  3PKE A;  1W2M A;  1BOA A;  1C24 A;  2B3H A;  2Q8K A;  1WKM A;  4S00 A;  3FMQ A;  5D6F A;  2Q94 A;  4FLI A;  4IKR A;  1QXZ A;  5FCH A;  2B3K A;  2GZ5 A;  3BIP A;  1B6A A;  4ZWP A;  1WL9 A;  2GG2 A;  2GGB A;  1B59 A;  2BH3 A;  2GU4 A;  2V6C A;  4U6C A;  2OKN A;  2BWU A;  5D6E A;  5CDL A;  2BWW A;  2GG8 A;  1WN1 A;  4KM3 A;  2EVO A;  4RZZ A;  1YW8 A;  3MAT A;  1R5G A;  1WLR A;  2GU7 A;  4FO7 A;  2EA4 A;  3FM3 A;  5CDE A;  4A6W A;  5JHU A;  1C23 A;  4U6J A;  2BWY A;  4IEC A;  2BHA A;  3IU9 A;  2BHB A;  1C22 A;  1C27 A;  1YVM A;  4RGZ 1;  2B3L A;  4PNC A;  3ROR A;  2GG0 A;  4U6Z A;  3S6B A;  1YW7 A;  2P98 A;  2BB7 A;  2EA2 A;  4OOK A;  2DFI A;  2GA2 A;  2GG9 A;  2ZSG A;  4IDY A;  2V3Z A;  1R58 A;  2V3X A;  3Q6D A;  4U70 A;  4U71 A;  2EVC A;  2BHD A;  4ZWU A;  4IKU A;  4FO8 A;  4U75 A;  2NQ6 A;  4Z7M A;  5CE6 A;  4IKS A;  3PKC A;  1Y1N A;  1YJ3 A;  4U6E A;  1O0X A;  1W7V A;  1CHM A;  2P9A A;  3TAV A;  2GG5 A;  3PKB A;  2G6P A;  2Q93 A;  4FLJ A;  3CTZ A;  4S2T P;  4FKC A;  3L7G A;  1KQ0 A;  1WBQ A;  2GTX A;  4MAT A;  2BWS A;  2BWT A;  4JUQ A;  4B28 A;  1XGN A;  4U69 A;  1QXY A;  1N51 A;  3IG4 A;  1C21 A;  4IU6 A;  5FCF A;  1YW9 A;  1BN5 A;  1XGO A;  2OAZ A;  3MR1 A;  2BWX A;  3BIT A;  3RVA A;  1A16 A;  2NQ7 A;  1XGS A;  3BIQ A;  2BN7 A;  2V3Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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