4IECA

Cys105 covalent modification by 2-hydroxyethyl disulfide in mycobacterium tuberculosis methionine aminopeptidase type 1c
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
280
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
total genus 86
structure length 280
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4iecA01
1N51A 2GG8A 5CE6A 4IKSA 4U69A 2G6PA 2GA2A 2GU7A 2BWTA 4A6VA 2Q8KA 2ADUA 2BHCA 4HXXA 4OOKA 3FMRA 1WY2A 4ZWOA 4RZZA 2BHDA 2Q92A 3MX6A 4FKCA 2Q94A 1XGOA 1XGMA 1CHMA 2EA4A 3BIPA 3CTZA 1MATA 4U6WA 1WLRA 5FCHA 2OKNA 2BH3A 2HOWA 4PNCA 4A6WA 4U70A 1PV9A 3IU7A 3BITA 3PKAA 1YW7A 3IU8A 1C22A 1QXZA 4FLIA 4S01A 5CLSA 3L24A 1YVMA 2EVMA 1XGNA 4ZWPA 2BB7A 1R58A 2GU6A 2GTXA 5CNXA 1R5HA 4Z7MA 4U76A 5JFRA 2BHAA 1WBQA 1WL6A 2NQ7A 3FMQA 2GG7A 4S2TP 2OAZA 4U6CA 4FUKA 1R5GA 1QZYA 4ZNGA 4FLKA 4U73A 4U6ZA 2MATA 5JHUA 4U1BA 3CB5A 5CDLA 4U6JA 3IG4A 4U75A 2GGCA 2V3YA 4JUQA 1W7VA 1C24A 4U6EA 1KQ0A 3CB6A 3TAVA 2P98A 2BWUA 2GG3A 1XGSA 2GG5A 2Q93A 4IDYA 5D6FA 4IKUA 2BWSA 4QR8A 2V6CA 1BN5A 1XNZA 2BWWA 2V3XA 3S6BA 5CDEA 1B6AA 3IU9A 2ZSGA 2B3KA 2IW2A 1C23A 2EVCA 2EVOA 2GGBA 3MATA 3Q6DA 2BWYA 4RZYA 1Y1NA 2BN7A 4IKRA 2BHBA 3PKEA 1A16A 1M35A 2EA2A 1B59A 1YW8A 3PKCA 2V3ZA 4B28A 1JAWA 1C27A 1QXWA 3BIQA 4IF7A 4ZWUA 1YJ3A 2BWVA 1C21A 1WL9A 3FM3A 2Q95A 2GU4A 3D27A 4EGEA 2P9AA 3MR1A 2GG2A 2P99A 5D6EA 1YW9A 2GZ5A 3PKDA 4IKTA 4IU6A 5CDVA 2B3LA 1BOAA 1W2MA 2GU5A 2GG9A 4FO7A 1O0XA 1QXYA 1WN1A 4FO8A 4KM3A 4S00A 2BWXA 2Q96A 4MATA 2NQ6A 4FLJA 4RGZ1 5JI6A 3RORA 5FCFA 4FLLA 2GG0A 4U71A 3PKBA 1WKMA 4PV4A 5E5BA 2DFIA 4IECA 3TB5A 1KQ9A 3L7GA 1KP0A 4S2RP 4IPAA 5CIKA 3RVAA 2B3HA 4R60A
chains in the Genus database with same CATH superfamily
1N51A 2GG8A 5CE6A 4IKSA 4U69A 2G6PA 2GA2A 2GU7A 2BWTA 4A6VA 2Q8KA 2ADUA 2BHCA 4HXXA 4OOKA 3FMRA 1WY2A 4ZWOA 4RZZA 2BHDA 2Q92A 3MX6A 4FKCA 2Q94A 1XGOA 1XGMA 1CHMA 2EA4A 3BIPA 3CTZA 1MATA 4U6WA 1WLRA 5FCHA 2OKNA 2BH3A 2HOWA 4PNCA 4A6WA 4U70A 1PV9A 3IU7A 3BITA 3PKAA 1YW7A 3IU8A 1C22A 1QXZA 4FLIA 4S01A 5CLSA 3L24A 1YVMA 2EVMA 1XGNA 4ZWPA 2BB7A 1R58A 2GU6A 2GTXA 5CNXA 1R5HA 4Z7MA 4U76A 5JFRA 2BHAA 1WBQA 1WL6A 2NQ7A 3FMQA 2GG7A 4S2TP 2OAZA 4U6CA 4FUKA 1R5GA 1QZYA 4ZNGA 4FLKA 4U73A 4U6ZA 2MATA 5JHUA 4U1BA 3CB5A 5CDLA 4U6JA 3IG4A 4U75A 2GGCA 2V3YA 4JUQA 1W7VA 1C24A 4U6EA 1KQ0A 3CB6A 3TAVA 2P98A 2BWUA 2GG3A 1XGSA 2GG5A 2Q93A 4IDYA 5D6FA 4IKUA 2BWSA 4QR8A 2V6CA 1BN5A 1XNZA 2BWWA 2V3XA 3S6BA 5CDEA 1B6AA 3IU9A 2ZSGA 2B3KA 2IW2A 1C23A 2EVCA 2EVOA 2GGBA 3MATA 3Q6DA 2BWYA 4RZYA 1Y1NA 2BN7A 4IKRA 2BHBA 3PKEA 1A16A 1M35A 2EA2A 1B59A 1YW8A 3PKCA 2V3ZA 4B28A 1JAWA 1C27A 1QXWA 3BIQA 4IF7A 4ZWUA 1YJ3A 2BWVA 1C21A 1WL9A 3FM3A 2Q95A 2GU4A 3D27A 4EGEA 2P9AA 3MR1A 2GG2A 2P99A 5D6EA 1YW9A 2GZ5A 3PKDA 4IKTA 4IU6A 5CDVA 2B3LA 1BOAA 1W2MA 2GU5A 2GG9A 4FO7A 1O0XA 1QXYA 1WN1A 4FO8A 4KM3A 4S00A 2BWXA 2Q96A 4MATA 2NQ6A 4FLJA 4RGZ1 5JI6A 3RORA 5FCFA 4FLLA 2GG0A 4U71A 3PKBA 1WKMA 4PV4A 5E5BA 2DFIA 4IECA 3TB5A 1KQ9A 3L7GA 1KP0A 4S2RP 4IPAA 5CIKA 3RVAA 2B3HA 4R60A
chains in the Genus database with same CATH topology
1N51A 2GG8A 5CE6A 4IKSA 4U69A 2G6PA 2GA2A 2GU7A 2BWTA 4A6VA 2Q8KA 2ADUA 2BHCA 4HXXA 4OOKA 3FMRA 1WY2A 4ZWOA 4RZZA 2BHDA 2Q92A 3MX6A 4FKCA 2Q94A 1XGOA 1XGMA 1CHMA 2EA4A 3BIPA 3CTZA 1MATA 4U6WA 1WLRA 5FCHA 2OKNA 2BH3A 2HOWA 4PNCA 4A6WA 4U70A 1PV9A 3IU7A 3BITA 3PKAA 1YW7A 3IU8A 1C22A 1QXZA 4FLIA 4S01A 5CLSA 3L24A 1YVMA 2EVMA 1XGNA 4ZWPA 2BB7A 1R58A 2GU6A 2GTXA 5CNXA 1R5HA 4Z7MA 4U76A 5JFRA 2BHAA 1WBQA 1WL6A 2NQ7A 3FMQA 2GG7A 4S2TP 2OAZA 4U6CA 4FUKA 1R5GA 1QZYA 4ZNGA 4FLKA 4U73A 4U6ZA 2MATA 5JHUA 4U1BA 3CB5A 5CDLA 4U6JA 3IG4A 4U75A 2GGCA 2V3YA 4JUQA 1W7VA 1C24A 4U6EA 1KQ0A 3CB6A 3TAVA 2P98A 2BWUA 2GG3A 1XGSA 2GG5A 2Q93A 4IDYA 5D6FA 4IKUA 2BWSA 4QR8A 2V6CA 1BN5A 1XNZA 2BWWA 2V3XA 3S6BA 5CDEA 1B6AA 3IU9A 2ZSGA 2B3KA 2IW2A 1C23A 2EVCA 2EVOA 2GGBA 3MATA 3Q6DA 2BWYA 4RZYA 1Y1NA 2BN7A 4IKRA 2BHBA 3PKEA 1A16A 1M35A 2EA2A 1B59A 1YW8A 3PKCA 2V3ZA 4B28A 1JAWA 1C27A 1QXWA 3BIQA 4IF7A 4ZWUA 1YJ3A 2BWVA 1C21A 1WL9A 3FM3A 2Q95A 2GU4A 3D27A 4EGEA 2P9AA 3MR1A 2GG2A 2P99A 5D6EA 1YW9A 2GZ5A 3PKDA 4IKTA 4IU6A 5CDVA 2B3LA 1BOAA 1W2MA 2GU5A 2GG9A 4FO7A 1O0XA 1QXYA 1WN1A 4FO8A 4KM3A 4S00A 2BWXA 2Q96A 4MATA 2NQ6A 4FLJA 4RGZ1 5JI6A 3RORA 5FCFA 4FLLA 2GG0A 4U71A 3PKBA 1WKMA 4PV4A 5E5BA 2DFIA 4IECA 3TB5A 1KQ9A 3L7GA 1KP0A 4S2RP 4IPAA 5CIKA 3RVAA 2B3HA 4R60A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N51 A;  2GG8 A;  5CE6 A;  4IKS A;  4U69 A;  2G6P A;  2GA2 A;  2GU7 A;  2BWT A;  4A6V A;  2Q8K A;  2ADU A;  2BHC A;  4HXX A;  4OOK A;  3FMR A;  1WY2 A;  4ZWO A;  4RZZ A;  2BHD A;  2Q92 A;  3MX6 A;  4FKC A;  2Q94 A;  1XGO A;  1XGM A;  1CHM A;  2EA4 A;  3BIP A;  3CTZ A;  1MAT A;  4U6W A;  1WLR A;  5FCH A;  2OKN A;  2BH3 A;  2HOW A;  4PNC A;  4A6W A;  4U70 A;  1PV9 A;  3IU7 A;  3BIT A;  3PKA A;  1YW7 A;  3IU8 A;  1C22 A;  1QXZ A;  4FLI A;  4S01 A;  5CLS A;  3L24 A;  1YVM A;  2EVM A;  1XGN A;  4ZWP A;  2BB7 A;  1R58 A;  2GU6 A;  2GTX A;  5CNX A;  1R5H A;  4Z7M A;  4U76 A;  5JFR A;  2BHA A;  1WBQ A;  1WL6 A;  2NQ7 A;  3FMQ A;  2GG7 A;  4S2T P;  2OAZ A;  4U6C A;  4FUK A;  1R5G A;  1QZY A;  4ZNG A;  4FLK A;  4U73 A;  4U6Z A;  2MAT A;  5JHU A;  4U1B A;  3CB5 A;  5CDL A;  4U6J A;  3IG4 A;  4U75 A;  2GGC A;  2V3Y A;  4JUQ A;  1W7V A;  1C24 A;  4U6E A;  1KQ0 A;  3CB6 A;  3TAV A;  2P98 A;  2BWU A;  2GG3 A;  1XGS A;  2GG5 A;  2Q93 A;  4IDY A;  5D6F A;  4IKU A;  2BWS A;  4QR8 A;  2V6C A;  1BN5 A;  1XNZ A;  2BWW A;  2V3X A;  3S6B A;  5CDE A;  1B6A A;  3IU9 A;  2ZSG A;  2B3K A;  2IW2 A;  1C23 A;  2EVC A;  2EVO A;  2GGB A;  3MAT A;  3Q6D A;  2BWY A;  4RZY A;  1Y1N A;  2BN7 A;  4IKR A;  2BHB A;  3PKE A;  1A16 A;  1M35 A;  2EA2 A;  1B59 A;  1YW8 A;  3PKC A;  2V3Z A;  4B28 A;  1JAW A;  1C27 A;  1QXW A;  3BIQ A;  4IF7 A;  4ZWU A;  1YJ3 A;  2BWV A;  1C21 A;  1WL9 A;  3FM3 A;  2Q95 A;  2GU4 A;  3D27 A;  4EGE A;  2P9A A;  3MR1 A;  2GG2 A;  2P99 A;  5D6E A;  1YW9 A;  2GZ5 A;  3PKD A;  4IKT A;  4IU6 A;  5CDV A;  2B3L A;  1BOA A;  1W2M A;  2GU5 A;  2GG9 A;  4FO7 A;  1O0X A;  1QXY A;  1WN1 A;  4FO8 A;  4KM3 A;  4S00 A;  2BWX A;  2Q96 A;  4MAT A;  2NQ6 A;  4FLJ A;  4RGZ 1;  5JI6 A;  3ROR A;  5FCF A;  4FLL A;  2GG0 A;  4U71 A;  3PKB A;  1WKM A;  4PV4 A;  5E5B A;  2DFI A;  4IEC A;  3TB5 A;  1KQ9 A;  3L7G A;  1KP0 A;  4S2R P;  4IPA A;  5CIK A;  3RVA A;  2B3H A;  4R60 A; 
#chains in the Genus database with same CATH topology
 1N51 A;  2GG8 A;  5CE6 A;  4IKS A;  4U69 A;  2G6P A;  2GA2 A;  2GU7 A;  2BWT A;  4A6V A;  2Q8K A;  2ADU A;  2BHC A;  4HXX A;  4OOK A;  3FMR A;  1WY2 A;  4ZWO A;  4RZZ A;  2BHD A;  2Q92 A;  3MX6 A;  4FKC A;  2Q94 A;  1XGO A;  1XGM A;  1CHM A;  2EA4 A;  3BIP A;  3CTZ A;  1MAT A;  4U6W A;  1WLR A;  5FCH A;  2OKN A;  2BH3 A;  2HOW A;  4PNC A;  4A6W A;  4U70 A;  1PV9 A;  3IU7 A;  3BIT A;  3PKA A;  1YW7 A;  3IU8 A;  1C22 A;  1QXZ A;  4FLI A;  4S01 A;  5CLS A;  3L24 A;  1YVM A;  2EVM A;  1XGN A;  4ZWP A;  2BB7 A;  1R58 A;  2GU6 A;  2GTX A;  5CNX A;  1R5H A;  4Z7M A;  4U76 A;  5JFR A;  2BHA A;  1WBQ A;  1WL6 A;  2NQ7 A;  3FMQ A;  2GG7 A;  4S2T P;  2OAZ A;  4U6C A;  4FUK A;  1R5G A;  1QZY A;  4ZNG A;  4FLK A;  4U73 A;  4U6Z A;  2MAT A;  5JHU A;  4U1B A;  3CB5 A;  5CDL A;  4U6J A;  3IG4 A;  4U75 A;  2GGC A;  2V3Y A;  4JUQ A;  1W7V A;  1C24 A;  4U6E A;  1KQ0 A;  3CB6 A;  3TAV A;  2P98 A;  2BWU A;  2GG3 A;  1XGS A;  2GG5 A;  2Q93 A;  4IDY A;  5D6F A;  4IKU A;  2BWS A;  4QR8 A;  2V6C A;  1BN5 A;  1XNZ A;  2BWW A;  2V3X A;  3S6B A;  5CDE A;  1B6A A;  3IU9 A;  2ZSG A;  2B3K A;  2IW2 A;  1C23 A;  2EVC A;  2EVO A;  2GGB A;  3MAT A;  3Q6D A;  2BWY A;  4RZY A;  1Y1N A;  2BN7 A;  4IKR A;  2BHB A;  3PKE A;  1A16 A;  1M35 A;  2EA2 A;  1B59 A;  1YW8 A;  3PKC A;  2V3Z A;  4B28 A;  1JAW A;  1C27 A;  1QXW A;  3BIQ A;  4IF7 A;  4ZWU A;  1YJ3 A;  2BWV A;  1C21 A;  1WL9 A;  3FM3 A;  2Q95 A;  2GU4 A;  3D27 A;  4EGE A;  2P9A A;  3MR1 A;  2GG2 A;  2P99 A;  5D6E A;  1YW9 A;  2GZ5 A;  3PKD A;  4IKT A;  4IU6 A;  5CDV A;  2B3L A;  1BOA A;  1W2M A;  2GU5 A;  2GG9 A;  4FO7 A;  1O0X A;  1QXY A;  1WN1 A;  4FO8 A;  4KM3 A;  4S00 A;  2BWX A;  2Q96 A;  4MAT A;  2NQ6 A;  4FLJ A;  4RGZ 1;  5JI6 A;  3ROR A;  5FCF A;  4FLL A;  2GG0 A;  4U71 A;  3PKB A;  1WKM A;  4PV4 A;  5E5B A;  2DFI A;  4IEC A;  3TB5 A;  1KQ9 A;  3L7G A;  1KP0 A;  4S2R P;  4IPA A;  5CIK A;  3RVA A;  2B3H A;  4R60 A; 
#chains in the Genus database with same CATH homology
 1N51 A;  2GG8 A;  5CE6 A;  4IKS A;  4U69 A;  2G6P A;  2GA2 A;  2GU7 A;  2BWT A;  4A6V A;  2Q8K A;  2ADU A;  2BHC A;  4HXX A;  4OOK A;  3FMR A;  1WY2 A;  4ZWO A;  4RZZ A;  2BHD A;  2Q92 A;  3MX6 A;  4FKC A;  2Q94 A;  1XGO A;  1XGM A;  1CHM A;  2EA4 A;  3BIP A;  3CTZ A;  1MAT A;  4U6W A;  1WLR A;  5FCH A;  2OKN A;  2BH3 A;  2HOW A;  4PNC A;  4A6W A;  4U70 A;  1PV9 A;  3IU7 A;  3BIT A;  3PKA A;  1YW7 A;  3IU8 A;  1C22 A;  1QXZ A;  4FLI A;  4S01 A;  5CLS A;  3L24 A;  1YVM A;  2EVM A;  1XGN A;  4ZWP A;  2BB7 A;  1R58 A;  2GU6 A;  2GTX A;  5CNX A;  1R5H A;  4Z7M A;  4U76 A;  5JFR A;  2BHA A;  1WBQ A;  1WL6 A;  2NQ7 A;  3FMQ A;  2GG7 A;  4S2T P;  2OAZ A;  4U6C A;  4FUK A;  1R5G A;  1QZY A;  4ZNG A;  4FLK A;  4U73 A;  4U6Z A;  2MAT A;  5JHU A;  4U1B A;  3CB5 A;  5CDL A;  4U6J A;  3IG4 A;  4U75 A;  2GGC A;  2V3Y A;  4JUQ A;  1W7V A;  1C24 A;  4U6E A;  1KQ0 A;  3CB6 A;  3TAV A;  2P98 A;  2BWU A;  2GG3 A;  1XGS A;  2GG5 A;  2Q93 A;  4IDY A;  5D6F A;  4IKU A;  2BWS A;  4QR8 A;  2V6C A;  1BN5 A;  1XNZ A;  2BWW A;  2V3X A;  3S6B A;  5CDE A;  1B6A A;  3IU9 A;  2ZSG A;  2B3K A;  2IW2 A;  1C23 A;  2EVC A;  2EVO A;  2GGB A;  3MAT A;  3Q6D A;  2BWY A;  4RZY A;  1Y1N A;  2BN7 A;  4IKR A;  2BHB A;  3PKE A;  1A16 A;  1M35 A;  2EA2 A;  1B59 A;  1YW8 A;  3PKC A;  2V3Z A;  4B28 A;  1JAW A;  1C27 A;  1QXW A;  3BIQ A;  4IF7 A;  4ZWU A;  1YJ3 A;  2BWV A;  1C21 A;  1WL9 A;  3FM3 A;  2Q95 A;  2GU4 A;  3D27 A;  4EGE A;  2P9A A;  3MR1 A;  2GG2 A;  2P99 A;  5D6E A;  1YW9 A;  2GZ5 A;  3PKD A;  4IKT A;  4IU6 A;  5CDV A;  2B3L A;  1BOA A;  1W2M A;  2GU5 A;  2GG9 A;  4FO7 A;  1O0X A;  1QXY A;  1WN1 A;  4FO8 A;  4KM3 A;  4S00 A;  2BWX A;  2Q96 A;  4MAT A;  2NQ6 A;  4FLJ A;  4RGZ 1;  5JI6 A;  3ROR A;  5FCF A;  4FLL A;  2GG0 A;  4U71 A;  3PKB A;  1WKM A;  4PV4 A;  5E5B A;  2DFI A;  4IEC A;  3TB5 A;  1KQ9 A;  3L7G A;  1KP0 A;  4S2R P;  4IPA A;  5CIK A;  3RVA A;  2B3H A;  4R60 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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