4IECA

Cys105 covalent modification by 2-hydroxyethyl disulfide in mycobacterium tuberculosis methionine aminopeptidase type 1c
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
280
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
total genus 86
structure length 280
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4iecA01
1N51A 2BN7A 2GG8A 4FO7A 2G6PA 1C27A 4ZNGA 2Q94A 4KM3A 4ZWOA 1KQ9A 2Q95A 2BB7A 5JHUA 3FMQA 4R60A 4MATA 1XGOA 3RORA 2BWVA 1B59A 1WBQA 3L7GA 4U73A 2GU7A 3IU9A 2EA2A 1PV9A 1A16A 1C24A 2V6CA 1JAWA 4U6EA 3TAVA 2GG7A 4JUQA 3MATA 4A6VA 2EVOA 1WL9A 3PKAA 4U71A 4RZYA 1MATA 2BWTA 2GU4A 4FO8A 4B28A 1BN5A 2BWWA 3D27A 2ZSGA 1C23A 1WKMA 4FLJA 2Q93A 1B6AA 2P99A 5CDVA 2GGCA 2GTXA 1CHMA 2B3KA 2DFIA 4RGZ1 1YVMA 2GZ5A 4U69A 3RVAA 3IU7A 5CDLA 5D6EA 1XGSA 5E5BA 1BOAA 5CLSA 4U6WA 2NQ7A 3IG4A 4U76A 2Q96A 3PKDA 2HOWA 5JI6A 4FLIA 1W7VA 2V3XA 4U75A 4ZWPA 2BWYA 2BWUA 4OOKA 4QR8A 2BHAA 1YW8A 2Q92A 1C21A 2GA2A 2GG0A 3FMRA 2BHBA 4EGEA 2GU5A 4PNCA 5JFRA 4U1BA 4U70A 4S2TP 1R58A 2EA4A 3PKCA 1QXYA 1M35A 2GGBA 2GU6A 1WL6A 1YW7A 3CB6A 4IDYA 4FUKA 4A6WA 2GG9A 4IECA 1WN1A 2P9AA 4IU6A 4RZZA 1QXWA 3MX6A 2BHDA 2GG5A 2OKNA 4Z7MA 5FCHA 2EVMA 5CNXA 4U6ZA 3CB5A 4IPAA 1QZYA 4IKTA 3BIQA 2BH3A 1KP0A 1R5HA 2ADUA 2BWXA 4S2RP 1WLRA 3S6BA 2BHCA 1O0XA 2OAZA 1C22A 2GG2A 3PKBA 2B3LA 4PV4A 1YJ3A 2MATA 1Y1NA 5CDEA 3Q6DA 1KQ0A 2B3HA 2Q8KA 2IW2A 3PKEA 4S01A 1QXZA 1W2MA 4IF7A 4U6CA 5FCFA 2P98A 2EVCA 4FLLA 5D6FA 4IKUA 3CTZA 5CE6A 1XGNA 2NQ6A 2GG3A 4ZWUA 3TB5A 3BIPA 4S00A 4U6JA 2V3ZA 1XNZA 2V3YA 3BITA 2BWSA 4FKCA 4FLKA 1YW9A 3FM3A 1R5GA 1WY2A 4IKRA 5CIKA 1XGMA 4IKSA 4HXXA 3L24A 3IU8A 3MR1A
chains in the Genus database with same CATH superfamily
1N51A 2BN7A 2GG8A 4FO7A 2G6PA 1C27A 4ZNGA 2Q94A 4KM3A 4ZWOA 1KQ9A 2Q95A 2BB7A 5JHUA 3FMQA 4R60A 4MATA 1XGOA 3RORA 2BWVA 1B59A 1WBQA 3L7GA 4U73A 2GU7A 3IU9A 2EA2A 1PV9A 1A16A 1C24A 2V6CA 1JAWA 4U6EA 3TAVA 2GG7A 4JUQA 3MATA 4A6VA 2EVOA 1WL9A 3PKAA 4U71A 4RZYA 1MATA 2BWTA 2GU4A 4FO8A 4B28A 1BN5A 2BWWA 3D27A 2ZSGA 1C23A 1WKMA 4FLJA 2Q93A 1B6AA 2P99A 5CDVA 2GGCA 2GTXA 1CHMA 2B3KA 2DFIA 4RGZ1 1YVMA 2GZ5A 4U69A 3RVAA 3IU7A 5CDLA 5D6EA 1XGSA 5E5BA 1BOAA 5CLSA 4U6WA 2NQ7A 3IG4A 4U76A 2Q96A 3PKDA 2HOWA 5JI6A 4FLIA 1W7VA 2V3XA 4U75A 4ZWPA 2BWYA 2BWUA 4OOKA 4QR8A 2BHAA 1YW8A 2Q92A 1C21A 2GA2A 2GG0A 3FMRA 2BHBA 4EGEA 2GU5A 4PNCA 5JFRA 4U1BA 4U70A 4S2TP 1R58A 2EA4A 3PKCA 1QXYA 1M35A 2GGBA 2GU6A 1WL6A 1YW7A 3CB6A 4IDYA 4FUKA 4A6WA 2GG9A 4IECA 1WN1A 2P9AA 4IU6A 4RZZA 1QXWA 3MX6A 2BHDA 2GG5A 2OKNA 4Z7MA 5FCHA 2EVMA 5CNXA 4U6ZA 3CB5A 4IPAA 1QZYA 4IKTA 3BIQA 2BH3A 1KP0A 1R5HA 2ADUA 2BWXA 4S2RP 1WLRA 3S6BA 2BHCA 1O0XA 2OAZA 1C22A 2GG2A 3PKBA 2B3LA 4PV4A 1YJ3A 2MATA 1Y1NA 5CDEA 3Q6DA 1KQ0A 2B3HA 2Q8KA 2IW2A 3PKEA 4S01A 1QXZA 1W2MA 4IF7A 4U6CA 5FCFA 2P98A 2EVCA 4FLLA 5D6FA 4IKUA 3CTZA 5CE6A 1XGNA 2NQ6A 2GG3A 4ZWUA 3TB5A 3BIPA 4S00A 4U6JA 2V3ZA 1XNZA 2V3YA 3BITA 2BWSA 4FKCA 4FLKA 1YW9A 3FM3A 1R5GA 1WY2A 4IKRA 5CIKA 1XGMA 4IKSA 4HXXA 3L24A 3IU8A 3MR1A
chains in the Genus database with same CATH topology
1N51A 2BN7A 2GG8A 4FO7A 2G6PA 1C27A 4ZNGA 2Q94A 4KM3A 4ZWOA 1KQ9A 2Q95A 2BB7A 5JHUA 3FMQA 4R60A 4MATA 1XGOA 3RORA 2BWVA 1B59A 1WBQA 3L7GA 4U73A 2GU7A 3IU9A 2EA2A 1PV9A 1A16A 1C24A 2V6CA 1JAWA 4U6EA 3TAVA 2GG7A 4JUQA 3MATA 4A6VA 2EVOA 1WL9A 3PKAA 4U71A 4RZYA 1MATA 2BWTA 2GU4A 4FO8A 4B28A 1BN5A 2BWWA 3D27A 2ZSGA 1C23A 1WKMA 4FLJA 2Q93A 1B6AA 2P99A 5CDVA 2GGCA 2GTXA 1CHMA 2B3KA 2DFIA 4RGZ1 1YVMA 2GZ5A 4U69A 3RVAA 3IU7A 5CDLA 5D6EA 1XGSA 5E5BA 1BOAA 5CLSA 4U6WA 2NQ7A 3IG4A 4U76A 2Q96A 3PKDA 2HOWA 5JI6A 4FLIA 1W7VA 2V3XA 4U75A 4ZWPA 2BWYA 2BWUA 4OOKA 4QR8A 2BHAA 1YW8A 2Q92A 1C21A 2GA2A 2GG0A 3FMRA 2BHBA 4EGEA 2GU5A 4PNCA 5JFRA 4U1BA 4U70A 4S2TP 1R58A 2EA4A 3PKCA 1QXYA 1M35A 2GGBA 2GU6A 1WL6A 1YW7A 3CB6A 4IDYA 4FUKA 4A6WA 2GG9A 4IECA 1WN1A 2P9AA 4IU6A 4RZZA 1QXWA 3MX6A 2BHDA 2GG5A 2OKNA 4Z7MA 5FCHA 2EVMA 5CNXA 4U6ZA 3CB5A 4IPAA 1QZYA 4IKTA 3BIQA 2BH3A 1KP0A 1R5HA 2ADUA 2BWXA 4S2RP 1WLRA 3S6BA 2BHCA 1O0XA 2OAZA 1C22A 2GG2A 3PKBA 2B3LA 4PV4A 1YJ3A 2MATA 1Y1NA 5CDEA 3Q6DA 1KQ0A 2B3HA 2Q8KA 2IW2A 3PKEA 4S01A 1QXZA 1W2MA 4IF7A 4U6CA 5FCFA 2P98A 2EVCA 4FLLA 5D6FA 4IKUA 3CTZA 5CE6A 1XGNA 2NQ6A 2GG3A 4ZWUA 3TB5A 3BIPA 4S00A 4U6JA 2V3ZA 1XNZA 2V3YA 3BITA 2BWSA 4FKCA 4FLKA 1YW9A 3FM3A 1R5GA 1WY2A 4IKRA 5CIKA 1XGMA 4IKSA 4HXXA 3L24A 3IU8A 3MR1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1N51 A;  2BN7 A;  2GG8 A;  4FO7 A;  2G6P A;  1C27 A;  4ZNG A;  2Q94 A;  4KM3 A;  4ZWO A;  1KQ9 A;  2Q95 A;  2BB7 A;  5JHU A;  3FMQ A;  4R60 A;  4MAT A;  1XGO A;  3ROR A;  2BWV A;  1B59 A;  1WBQ A;  3L7G A;  4U73 A;  2GU7 A;  3IU9 A;  2EA2 A;  1PV9 A;  1A16 A;  1C24 A;  2V6C A;  1JAW A;  4U6E A;  3TAV A;  2GG7 A;  4JUQ A;  3MAT A;  4A6V A;  2EVO A;  1WL9 A;  3PKA A;  4U71 A;  4RZY A;  1MAT A;  2BWT A;  2GU4 A;  4FO8 A;  4B28 A;  1BN5 A;  2BWW A;  3D27 A;  2ZSG A;  1C23 A;  1WKM A;  4FLJ A;  2Q93 A;  1B6A A;  2P99 A;  5CDV A;  2GGC A;  2GTX A;  1CHM A;  2B3K A;  2DFI A;  4RGZ 1;  1YVM A;  2GZ5 A;  4U69 A;  3RVA A;  3IU7 A;  5CDL A;  5D6E A;  1XGS A;  5E5B A;  1BOA A;  5CLS A;  4U6W A;  2NQ7 A;  3IG4 A;  4U76 A;  2Q96 A;  3PKD A;  2HOW A;  5JI6 A;  4FLI A;  1W7V A;  2V3X A;  4U75 A;  4ZWP A;  2BWY A;  2BWU A;  4OOK A;  4QR8 A;  2BHA A;  1YW8 A;  2Q92 A;  1C21 A;  2GA2 A;  2GG0 A;  3FMR A;  2BHB A;  4EGE A;  2GU5 A;  4PNC A;  5JFR A;  4U1B A;  4U70 A;  4S2T P;  1R58 A;  2EA4 A;  3PKC A;  1QXY A;  1M35 A;  2GGB A;  2GU6 A;  1WL6 A;  1YW7 A;  3CB6 A;  4IDY A;  4FUK A;  4A6W A;  2GG9 A;  4IEC A;  1WN1 A;  2P9A A;  4IU6 A;  4RZZ A;  1QXW A;  3MX6 A;  2BHD A;  2GG5 A;  2OKN A;  4Z7M A;  5FCH A;  2EVM A;  5CNX A;  4U6Z A;  3CB5 A;  4IPA A;  1QZY A;  4IKT A;  3BIQ A;  2BH3 A;  1KP0 A;  1R5H A;  2ADU A;  2BWX A;  4S2R P;  1WLR A;  3S6B A;  2BHC A;  1O0X A;  2OAZ A;  1C22 A;  2GG2 A;  3PKB A;  2B3L A;  4PV4 A;  1YJ3 A;  2MAT A;  1Y1N A;  5CDE A;  3Q6D A;  1KQ0 A;  2B3H A;  2Q8K A;  2IW2 A;  3PKE A;  4S01 A;  1QXZ A;  1W2M A;  4IF7 A;  4U6C A;  5FCF A;  2P98 A;  2EVC A;  4FLL A;  5D6F A;  4IKU A;  3CTZ A;  5CE6 A;  1XGN A;  2NQ6 A;  2GG3 A;  4ZWU A;  3TB5 A;  3BIP A;  4S00 A;  4U6J A;  2V3Z A;  1XNZ A;  2V3Y A;  3BIT A;  2BWS A;  4FKC A;  4FLK A;  1YW9 A;  3FM3 A;  1R5G A;  1WY2 A;  4IKR A;  5CIK A;  1XGM A;  4IKS A;  4HXX A;  3L24 A;  3IU8 A;  3MR1 A; 
#chains in the Genus database with same CATH topology
 1N51 A;  2BN7 A;  2GG8 A;  4FO7 A;  2G6P A;  1C27 A;  4ZNG A;  2Q94 A;  4KM3 A;  4ZWO A;  1KQ9 A;  2Q95 A;  2BB7 A;  5JHU A;  3FMQ A;  4R60 A;  4MAT A;  1XGO A;  3ROR A;  2BWV A;  1B59 A;  1WBQ A;  3L7G A;  4U73 A;  2GU7 A;  3IU9 A;  2EA2 A;  1PV9 A;  1A16 A;  1C24 A;  2V6C A;  1JAW A;  4U6E A;  3TAV A;  2GG7 A;  4JUQ A;  3MAT A;  4A6V A;  2EVO A;  1WL9 A;  3PKA A;  4U71 A;  4RZY A;  1MAT A;  2BWT A;  2GU4 A;  4FO8 A;  4B28 A;  1BN5 A;  2BWW A;  3D27 A;  2ZSG A;  1C23 A;  1WKM A;  4FLJ A;  2Q93 A;  1B6A A;  2P99 A;  5CDV A;  2GGC A;  2GTX A;  1CHM A;  2B3K A;  2DFI A;  4RGZ 1;  1YVM A;  2GZ5 A;  4U69 A;  3RVA A;  3IU7 A;  5CDL A;  5D6E A;  1XGS A;  5E5B A;  1BOA A;  5CLS A;  4U6W A;  2NQ7 A;  3IG4 A;  4U76 A;  2Q96 A;  3PKD A;  2HOW A;  5JI6 A;  4FLI A;  1W7V A;  2V3X A;  4U75 A;  4ZWP A;  2BWY A;  2BWU A;  4OOK A;  4QR8 A;  2BHA A;  1YW8 A;  2Q92 A;  1C21 A;  2GA2 A;  2GG0 A;  3FMR A;  2BHB A;  4EGE A;  2GU5 A;  4PNC A;  5JFR A;  4U1B A;  4U70 A;  4S2T P;  1R58 A;  2EA4 A;  3PKC A;  1QXY A;  1M35 A;  2GGB A;  2GU6 A;  1WL6 A;  1YW7 A;  3CB6 A;  4IDY A;  4FUK A;  4A6W A;  2GG9 A;  4IEC A;  1WN1 A;  2P9A A;  4IU6 A;  4RZZ A;  1QXW A;  3MX6 A;  2BHD A;  2GG5 A;  2OKN A;  4Z7M A;  5FCH A;  2EVM A;  5CNX A;  4U6Z A;  3CB5 A;  4IPA A;  1QZY A;  4IKT A;  3BIQ A;  2BH3 A;  1KP0 A;  1R5H A;  2ADU A;  2BWX A;  4S2R P;  1WLR A;  3S6B A;  2BHC A;  1O0X A;  2OAZ A;  1C22 A;  2GG2 A;  3PKB A;  2B3L A;  4PV4 A;  1YJ3 A;  2MAT A;  1Y1N A;  5CDE A;  3Q6D A;  1KQ0 A;  2B3H A;  2Q8K A;  2IW2 A;  3PKE A;  4S01 A;  1QXZ A;  1W2M A;  4IF7 A;  4U6C A;  5FCF A;  2P98 A;  2EVC A;  4FLL A;  5D6F A;  4IKU A;  3CTZ A;  5CE6 A;  1XGN A;  2NQ6 A;  2GG3 A;  4ZWU A;  3TB5 A;  3BIP A;  4S00 A;  4U6J A;  2V3Z A;  1XNZ A;  2V3Y A;  3BIT A;  2BWS A;  4FKC A;  4FLK A;  1YW9 A;  3FM3 A;  1R5G A;  1WY2 A;  4IKR A;  5CIK A;  1XGM A;  4IKS A;  4HXX A;  3L24 A;  3IU8 A;  3MR1 A; 
#chains in the Genus database with same CATH homology
 1N51 A;  2BN7 A;  2GG8 A;  4FO7 A;  2G6P A;  1C27 A;  4ZNG A;  2Q94 A;  4KM3 A;  4ZWO A;  1KQ9 A;  2Q95 A;  2BB7 A;  5JHU A;  3FMQ A;  4R60 A;  4MAT A;  1XGO A;  3ROR A;  2BWV A;  1B59 A;  1WBQ A;  3L7G A;  4U73 A;  2GU7 A;  3IU9 A;  2EA2 A;  1PV9 A;  1A16 A;  1C24 A;  2V6C A;  1JAW A;  4U6E A;  3TAV A;  2GG7 A;  4JUQ A;  3MAT A;  4A6V A;  2EVO A;  1WL9 A;  3PKA A;  4U71 A;  4RZY A;  1MAT A;  2BWT A;  2GU4 A;  4FO8 A;  4B28 A;  1BN5 A;  2BWW A;  3D27 A;  2ZSG A;  1C23 A;  1WKM A;  4FLJ A;  2Q93 A;  1B6A A;  2P99 A;  5CDV A;  2GGC A;  2GTX A;  1CHM A;  2B3K A;  2DFI A;  4RGZ 1;  1YVM A;  2GZ5 A;  4U69 A;  3RVA A;  3IU7 A;  5CDL A;  5D6E A;  1XGS A;  5E5B A;  1BOA A;  5CLS A;  4U6W A;  2NQ7 A;  3IG4 A;  4U76 A;  2Q96 A;  3PKD A;  2HOW A;  5JI6 A;  4FLI A;  1W7V A;  2V3X A;  4U75 A;  4ZWP A;  2BWY A;  2BWU A;  4OOK A;  4QR8 A;  2BHA A;  1YW8 A;  2Q92 A;  1C21 A;  2GA2 A;  2GG0 A;  3FMR A;  2BHB A;  4EGE A;  2GU5 A;  4PNC A;  5JFR A;  4U1B A;  4U70 A;  4S2T P;  1R58 A;  2EA4 A;  3PKC A;  1QXY A;  1M35 A;  2GGB A;  2GU6 A;  1WL6 A;  1YW7 A;  3CB6 A;  4IDY A;  4FUK A;  4A6W A;  2GG9 A;  4IEC A;  1WN1 A;  2P9A A;  4IU6 A;  4RZZ A;  1QXW A;  3MX6 A;  2BHD A;  2GG5 A;  2OKN A;  4Z7M A;  5FCH A;  2EVM A;  5CNX A;  4U6Z A;  3CB5 A;  4IPA A;  1QZY A;  4IKT A;  3BIQ A;  2BH3 A;  1KP0 A;  1R5H A;  2ADU A;  2BWX A;  4S2R P;  1WLR A;  3S6B A;  2BHC A;  1O0X A;  2OAZ A;  1C22 A;  2GG2 A;  3PKB A;  2B3L A;  4PV4 A;  1YJ3 A;  2MAT A;  1Y1N A;  5CDE A;  3Q6D A;  1KQ0 A;  2B3H A;  2Q8K A;  2IW2 A;  3PKE A;  4S01 A;  1QXZ A;  1W2M A;  4IF7 A;  4U6C A;  5FCF A;  2P98 A;  2EVC A;  4FLL A;  5D6F A;  4IKU A;  3CTZ A;  5CE6 A;  1XGN A;  2NQ6 A;  2GG3 A;  4ZWU A;  3TB5 A;  3BIP A;  4S00 A;  4U6J A;  2V3Z A;  1XNZ A;  2V3Y A;  3BIT A;  2BWS A;  4FKC A;  4FLK A;  1YW9 A;  3FM3 A;  1R5G A;  1WY2 A;  4IKR A;  5CIK A;  1XGM A;  4IKS A;  4HXX A;  3L24 A;  3IU8 A;  3MR1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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