4IECA

Cys105 covalent modification by 2-hydroxyethyl disulfide in mycobacterium tuberculosis methionine aminopeptidase type 1c
Total Genus 86
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
280
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
total genus 86
structure length 280
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4iecA01
3D27A 4Z7MA 2GGCA 2GG2A 1KP0A 3MR1A 2B3LA 3BITA 4FLJA 1C24A 3L24A 5CDVA 3PKBA 3PKDA 3CB6A 1PV9A 2BH3A 4S01A 1QXZA 4IDYA 4FLKA 1C22A 2OKNA 4ZNGA 1BOAA 2ADUA 4U70A 5CDEA 1MATA 5E5BA 2BHDA 3S6BA 4U71A 3MATA 2GA2A 1JAWA 4U6ZA 1YJ3A 5FCHA 3RVAA 2V3YA 2BWSA 2BHBA 4S00A 1YW8A 1XGOA 2MATA 4OOKA 1O0XA 5CNXA 1A16A 2Q95A 1YW7A 2OAZA 2Q94A 1XNZA 4MATA 4FKCA 2GU5A 1R5HA 4S2RP 3CB5A 4RZYA 4A6VA 3FMRA 5D6FA 4IKSA 5JI6A 1C23A 1CHMA 2G6PA 3CTZA 4ZWPA 1R5GA 2BWWA 2BWYA 4IU6A 2IW2A 3TB5A 4PV4A 1XGMA 1C27A 2V6CA 2EVCA 4IKTA 4U1BA 2GU6A 4U6JA 2GZ5A 4U76A 5CLSA 2BHCA 4FO7A 2NQ7A 3FM3A 4RZZA 2BWXA 5CDLA 5D6EA 4EGEA 2P98A 1XGSA 2P99A 3IU9A 4QR8A 3BIPA 3BIQA 4U6CA 4U6WA 3MX6A 2DFIA 1B59A 2Q92A 1B6AA 4U69A 3L7GA 2GG5A 2BWVA 2GG3A 4HXXA 1W2MA 2GU4A 4S2TP 1N51A 2V3ZA 2NQ6A 1WKMA 3PKEA 1WLRA 4IPAA 3IG4A 1Y1NA 3Q6DA 2GU7A 2GG0A 2EVMA 1QXWA 2GTXA 4IKRA 1M35A 4U73A 4IKUA 2HOWA 2BWUA 2Q8KA 4R60A 4RGZ1 2B3KA 1BN5A 4ZWOA 2BB7A 4FLLA 2GG8A 3FMQA 2EA2A 3IU7A 2BN7A 5JHUA 2EA4A 4PNCA 3IU8A 1R58A 4B28A 1QXYA 4U75A 1YW9A 2GGBA 4FO8A 2Q93A 3RORA 4FLIA 1WBQA 1KQ9A 2GG9A 1WL9A 2ZSGA 1QZYA 1C21A 3PKCA 4IECA 4U6EA 1XGNA 5FCFA 1WY2A 2BWTA 2EVOA 1WN1A 4IF7A 1W7VA 4FUKA 5CIKA 4JUQA 1KQ0A 2P9AA 3TAVA 1YVMA 2GG7A 2B3HA 4KM3A 1WL6A 4A6WA 2Q96A 2V3XA 3PKAA 4ZWUA 5JFRA 2BHAA 5CE6A
chains in the Genus database with same CATH superfamily
3D27A 4Z7MA 2GGCA 2GG2A 1KP0A 3MR1A 2B3LA 3BITA 4FLJA 1C24A 3L24A 5CDVA 3PKBA 3PKDA 3CB6A 1PV9A 2BH3A 4S01A 1QXZA 4IDYA 4FLKA 1C22A 2OKNA 4ZNGA 1BOAA 2ADUA 4U70A 5CDEA 1MATA 5E5BA 2BHDA 3S6BA 4U71A 3MATA 2GA2A 1JAWA 4U6ZA 1YJ3A 5FCHA 3RVAA 2V3YA 2BWSA 2BHBA 4S00A 1YW8A 1XGOA 2MATA 4OOKA 1O0XA 5CNXA 1A16A 2Q95A 1YW7A 2OAZA 2Q94A 1XNZA 4MATA 4FKCA 2GU5A 1R5HA 4S2RP 3CB5A 4RZYA 4A6VA 3FMRA 5D6FA 4IKSA 5JI6A 1C23A 1CHMA 2G6PA 3CTZA 4ZWPA 1R5GA 2BWWA 2BWYA 4IU6A 2IW2A 3TB5A 4PV4A 1XGMA 1C27A 2V6CA 2EVCA 4IKTA 4U1BA 2GU6A 4U6JA 2GZ5A 4U76A 5CLSA 2BHCA 4FO7A 2NQ7A 3FM3A 4RZZA 2BWXA 5CDLA 5D6EA 4EGEA 2P98A 1XGSA 2P99A 3IU9A 4QR8A 3BIPA 3BIQA 4U6CA 4U6WA 3MX6A 2DFIA 1B59A 2Q92A 1B6AA 4U69A 3L7GA 2GG5A 2BWVA 2GG3A 4HXXA 1W2MA 2GU4A 4S2TP 1N51A 2V3ZA 2NQ6A 1WKMA 3PKEA 1WLRA 4IPAA 3IG4A 1Y1NA 3Q6DA 2GU7A 2GG0A 2EVMA 1QXWA 2GTXA 4IKRA 1M35A 4U73A 4IKUA 2HOWA 2BWUA 2Q8KA 4R60A 4RGZ1 2B3KA 1BN5A 4ZWOA 2BB7A 4FLLA 2GG8A 3FMQA 2EA2A 3IU7A 2BN7A 5JHUA 2EA4A 4PNCA 3IU8A 1R58A 4B28A 1QXYA 4U75A 1YW9A 2GGBA 4FO8A 2Q93A 3RORA 4FLIA 1WBQA 1KQ9A 2GG9A 1WL9A 2ZSGA 1QZYA 1C21A 3PKCA 4IECA 4U6EA 1XGNA 5FCFA 1WY2A 2BWTA 2EVOA 1WN1A 4IF7A 1W7VA 4FUKA 5CIKA 4JUQA 1KQ0A 2P9AA 3TAVA 1YVMA 2GG7A 2B3HA 4KM3A 1WL6A 4A6WA 2Q96A 2V3XA 3PKAA 4ZWUA 5JFRA 2BHAA 5CE6A
chains in the Genus database with same CATH topology
3D27A 4Z7MA 2GGCA 2GG2A 1KP0A 3MR1A 2B3LA 3BITA 4FLJA 1C24A 3L24A 5CDVA 3PKBA 3PKDA 3CB6A 1PV9A 2BH3A 4S01A 1QXZA 4IDYA 4FLKA 1C22A 2OKNA 4ZNGA 1BOAA 2ADUA 4U70A 5CDEA 1MATA 5E5BA 2BHDA 3S6BA 4U71A 3MATA 2GA2A 1JAWA 4U6ZA 1YJ3A 5FCHA 3RVAA 2V3YA 2BWSA 2BHBA 4S00A 1YW8A 1XGOA 2MATA 4OOKA 1O0XA 5CNXA 1A16A 2Q95A 1YW7A 2OAZA 2Q94A 1XNZA 4MATA 4FKCA 2GU5A 1R5HA 4S2RP 3CB5A 4RZYA 4A6VA 3FMRA 5D6FA 4IKSA 5JI6A 1C23A 1CHMA 2G6PA 3CTZA 4ZWPA 1R5GA 2BWWA 2BWYA 4IU6A 2IW2A 3TB5A 4PV4A 1XGMA 1C27A 2V6CA 2EVCA 4IKTA 4U1BA 2GU6A 4U6JA 2GZ5A 4U76A 5CLSA 2BHCA 4FO7A 2NQ7A 3FM3A 4RZZA 2BWXA 5CDLA 5D6EA 4EGEA 2P98A 1XGSA 2P99A 3IU9A 4QR8A 3BIPA 3BIQA 4U6CA 4U6WA 3MX6A 2DFIA 1B59A 2Q92A 1B6AA 4U69A 3L7GA 2GG5A 2BWVA 2GG3A 4HXXA 1W2MA 2GU4A 4S2TP 1N51A 2V3ZA 2NQ6A 1WKMA 3PKEA 1WLRA 4IPAA 3IG4A 1Y1NA 3Q6DA 2GU7A 2GG0A 2EVMA 1QXWA 2GTXA 4IKRA 1M35A 4U73A 4IKUA 2HOWA 2BWUA 2Q8KA 4R60A 4RGZ1 2B3KA 1BN5A 4ZWOA 2BB7A 4FLLA 2GG8A 3FMQA 2EA2A 3IU7A 2BN7A 5JHUA 2EA4A 4PNCA 3IU8A 1R58A 4B28A 1QXYA 4U75A 1YW9A 2GGBA 4FO8A 2Q93A 3RORA 4FLIA 1WBQA 1KQ9A 2GG9A 1WL9A 2ZSGA 1QZYA 1C21A 3PKCA 4IECA 4U6EA 1XGNA 5FCFA 1WY2A 2BWTA 2EVOA 1WN1A 4IF7A 1W7VA 4FUKA 5CIKA 4JUQA 1KQ0A 2P9AA 3TAVA 1YVMA 2GG7A 2B3HA 4KM3A 1WL6A 4A6WA 2Q96A 2V3XA 3PKAA 4ZWUA 5JFRA 2BHAA 5CE6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3D27 A;  4Z7M A;  2GGC A;  2GG2 A;  1KP0 A;  3MR1 A;  2B3L A;  3BIT A;  4FLJ A;  1C24 A;  3L24 A;  5CDV A;  3PKB A;  3PKD A;  3CB6 A;  1PV9 A;  2BH3 A;  4S01 A;  1QXZ A;  4IDY A;  4FLK A;  1C22 A;  2OKN A;  4ZNG A;  1BOA A;  2ADU A;  4U70 A;  5CDE A;  1MAT A;  5E5B A;  2BHD A;  3S6B A;  4U71 A;  3MAT A;  2GA2 A;  1JAW A;  4U6Z A;  1YJ3 A;  5FCH A;  3RVA A;  2V3Y A;  2BWS A;  2BHB A;  4S00 A;  1YW8 A;  1XGO A;  2MAT A;  4OOK A;  1O0X A;  5CNX A;  1A16 A;  2Q95 A;  1YW7 A;  2OAZ A;  2Q94 A;  1XNZ A;  4MAT A;  4FKC A;  2GU5 A;  1R5H A;  4S2R P;  3CB5 A;  4RZY A;  4A6V A;  3FMR A;  5D6F A;  4IKS A;  5JI6 A;  1C23 A;  1CHM A;  2G6P A;  3CTZ A;  4ZWP A;  1R5G A;  2BWW A;  2BWY A;  4IU6 A;  2IW2 A;  3TB5 A;  4PV4 A;  1XGM A;  1C27 A;  2V6C A;  2EVC A;  4IKT A;  4U1B A;  2GU6 A;  4U6J A;  2GZ5 A;  4U76 A;  5CLS A;  2BHC A;  4FO7 A;  2NQ7 A;  3FM3 A;  4RZZ A;  2BWX A;  5CDL A;  5D6E A;  4EGE A;  2P98 A;  1XGS A;  2P99 A;  3IU9 A;  4QR8 A;  3BIP A;  3BIQ A;  4U6C A;  4U6W A;  3MX6 A;  2DFI A;  1B59 A;  2Q92 A;  1B6A A;  4U69 A;  3L7G A;  2GG5 A;  2BWV A;  2GG3 A;  4HXX A;  1W2M A;  2GU4 A;  4S2T P;  1N51 A;  2V3Z A;  2NQ6 A;  1WKM A;  3PKE A;  1WLR A;  4IPA A;  3IG4 A;  1Y1N A;  3Q6D A;  2GU7 A;  2GG0 A;  2EVM A;  1QXW A;  2GTX A;  4IKR A;  1M35 A;  4U73 A;  4IKU A;  2HOW A;  2BWU A;  2Q8K A;  4R60 A;  4RGZ 1;  2B3K A;  1BN5 A;  4ZWO A;  2BB7 A;  4FLL A;  2GG8 A;  3FMQ A;  2EA2 A;  3IU7 A;  2BN7 A;  5JHU A;  2EA4 A;  4PNC A;  3IU8 A;  1R58 A;  4B28 A;  1QXY A;  4U75 A;  1YW9 A;  2GGB A;  4FO8 A;  2Q93 A;  3ROR A;  4FLI A;  1WBQ A;  1KQ9 A;  2GG9 A;  1WL9 A;  2ZSG A;  1QZY A;  1C21 A;  3PKC A;  4IEC A;  4U6E A;  1XGN A;  5FCF A;  1WY2 A;  2BWT A;  2EVO A;  1WN1 A;  4IF7 A;  1W7V A;  4FUK A;  5CIK A;  4JUQ A;  1KQ0 A;  2P9A A;  3TAV A;  1YVM A;  2GG7 A;  2B3H A;  4KM3 A;  1WL6 A;  4A6W A;  2Q96 A;  2V3X A;  3PKA A;  4ZWU A;  5JFR A;  2BHA A;  5CE6 A; 
#chains in the Genus database with same CATH topology
 3D27 A;  4Z7M A;  2GGC A;  2GG2 A;  1KP0 A;  3MR1 A;  2B3L A;  3BIT A;  4FLJ A;  1C24 A;  3L24 A;  5CDV A;  3PKB A;  3PKD A;  3CB6 A;  1PV9 A;  2BH3 A;  4S01 A;  1QXZ A;  4IDY A;  4FLK A;  1C22 A;  2OKN A;  4ZNG A;  1BOA A;  2ADU A;  4U70 A;  5CDE A;  1MAT A;  5E5B A;  2BHD A;  3S6B A;  4U71 A;  3MAT A;  2GA2 A;  1JAW A;  4U6Z A;  1YJ3 A;  5FCH A;  3RVA A;  2V3Y A;  2BWS A;  2BHB A;  4S00 A;  1YW8 A;  1XGO A;  2MAT A;  4OOK A;  1O0X A;  5CNX A;  1A16 A;  2Q95 A;  1YW7 A;  2OAZ A;  2Q94 A;  1XNZ A;  4MAT A;  4FKC A;  2GU5 A;  1R5H A;  4S2R P;  3CB5 A;  4RZY A;  4A6V A;  3FMR A;  5D6F A;  4IKS A;  5JI6 A;  1C23 A;  1CHM A;  2G6P A;  3CTZ A;  4ZWP A;  1R5G A;  2BWW A;  2BWY A;  4IU6 A;  2IW2 A;  3TB5 A;  4PV4 A;  1XGM A;  1C27 A;  2V6C A;  2EVC A;  4IKT A;  4U1B A;  2GU6 A;  4U6J A;  2GZ5 A;  4U76 A;  5CLS A;  2BHC A;  4FO7 A;  2NQ7 A;  3FM3 A;  4RZZ A;  2BWX A;  5CDL A;  5D6E A;  4EGE A;  2P98 A;  1XGS A;  2P99 A;  3IU9 A;  4QR8 A;  3BIP A;  3BIQ A;  4U6C A;  4U6W A;  3MX6 A;  2DFI A;  1B59 A;  2Q92 A;  1B6A A;  4U69 A;  3L7G A;  2GG5 A;  2BWV A;  2GG3 A;  4HXX A;  1W2M A;  2GU4 A;  4S2T P;  1N51 A;  2V3Z A;  2NQ6 A;  1WKM A;  3PKE A;  1WLR A;  4IPA A;  3IG4 A;  1Y1N A;  3Q6D A;  2GU7 A;  2GG0 A;  2EVM A;  1QXW A;  2GTX A;  4IKR A;  1M35 A;  4U73 A;  4IKU A;  2HOW A;  2BWU A;  2Q8K A;  4R60 A;  4RGZ 1;  2B3K A;  1BN5 A;  4ZWO A;  2BB7 A;  4FLL A;  2GG8 A;  3FMQ A;  2EA2 A;  3IU7 A;  2BN7 A;  5JHU A;  2EA4 A;  4PNC A;  3IU8 A;  1R58 A;  4B28 A;  1QXY A;  4U75 A;  1YW9 A;  2GGB A;  4FO8 A;  2Q93 A;  3ROR A;  4FLI A;  1WBQ A;  1KQ9 A;  2GG9 A;  1WL9 A;  2ZSG A;  1QZY A;  1C21 A;  3PKC A;  4IEC A;  4U6E A;  1XGN A;  5FCF A;  1WY2 A;  2BWT A;  2EVO A;  1WN1 A;  4IF7 A;  1W7V A;  4FUK A;  5CIK A;  4JUQ A;  1KQ0 A;  2P9A A;  3TAV A;  1YVM A;  2GG7 A;  2B3H A;  4KM3 A;  1WL6 A;  4A6W A;  2Q96 A;  2V3X A;  3PKA A;  4ZWU A;  5JFR A;  2BHA A;  5CE6 A; 
#chains in the Genus database with same CATH homology
 3D27 A;  4Z7M A;  2GGC A;  2GG2 A;  1KP0 A;  3MR1 A;  2B3L A;  3BIT A;  4FLJ A;  1C24 A;  3L24 A;  5CDV A;  3PKB A;  3PKD A;  3CB6 A;  1PV9 A;  2BH3 A;  4S01 A;  1QXZ A;  4IDY A;  4FLK A;  1C22 A;  2OKN A;  4ZNG A;  1BOA A;  2ADU A;  4U70 A;  5CDE A;  1MAT A;  5E5B A;  2BHD A;  3S6B A;  4U71 A;  3MAT A;  2GA2 A;  1JAW A;  4U6Z A;  1YJ3 A;  5FCH A;  3RVA A;  2V3Y A;  2BWS A;  2BHB A;  4S00 A;  1YW8 A;  1XGO A;  2MAT A;  4OOK A;  1O0X A;  5CNX A;  1A16 A;  2Q95 A;  1YW7 A;  2OAZ A;  2Q94 A;  1XNZ A;  4MAT A;  4FKC A;  2GU5 A;  1R5H A;  4S2R P;  3CB5 A;  4RZY A;  4A6V A;  3FMR A;  5D6F A;  4IKS A;  5JI6 A;  1C23 A;  1CHM A;  2G6P A;  3CTZ A;  4ZWP A;  1R5G A;  2BWW A;  2BWY A;  4IU6 A;  2IW2 A;  3TB5 A;  4PV4 A;  1XGM A;  1C27 A;  2V6C A;  2EVC A;  4IKT A;  4U1B A;  2GU6 A;  4U6J A;  2GZ5 A;  4U76 A;  5CLS A;  2BHC A;  4FO7 A;  2NQ7 A;  3FM3 A;  4RZZ A;  2BWX A;  5CDL A;  5D6E A;  4EGE A;  2P98 A;  1XGS A;  2P99 A;  3IU9 A;  4QR8 A;  3BIP A;  3BIQ A;  4U6C A;  4U6W A;  3MX6 A;  2DFI A;  1B59 A;  2Q92 A;  1B6A A;  4U69 A;  3L7G A;  2GG5 A;  2BWV A;  2GG3 A;  4HXX A;  1W2M A;  2GU4 A;  4S2T P;  1N51 A;  2V3Z A;  2NQ6 A;  1WKM A;  3PKE A;  1WLR A;  4IPA A;  3IG4 A;  1Y1N A;  3Q6D A;  2GU7 A;  2GG0 A;  2EVM A;  1QXW A;  2GTX A;  4IKR A;  1M35 A;  4U73 A;  4IKU A;  2HOW A;  2BWU A;  2Q8K A;  4R60 A;  4RGZ 1;  2B3K A;  1BN5 A;  4ZWO A;  2BB7 A;  4FLL A;  2GG8 A;  3FMQ A;  2EA2 A;  3IU7 A;  2BN7 A;  5JHU A;  2EA4 A;  4PNC A;  3IU8 A;  1R58 A;  4B28 A;  1QXY A;  4U75 A;  1YW9 A;  2GGB A;  4FO8 A;  2Q93 A;  3ROR A;  4FLI A;  1WBQ A;  1KQ9 A;  2GG9 A;  1WL9 A;  2ZSG A;  1QZY A;  1C21 A;  3PKC A;  4IEC A;  4U6E A;  1XGN A;  5FCF A;  1WY2 A;  2BWT A;  2EVO A;  1WN1 A;  4IF7 A;  1W7V A;  4FUK A;  5CIK A;  4JUQ A;  1KQ0 A;  2P9A A;  3TAV A;  1YVM A;  2GG7 A;  2B3H A;  4KM3 A;  1WL6 A;  4A6W A;  2Q96 A;  2V3X A;  3PKA A;  4ZWU A;  5JFR A;  2BHA A;  5CE6 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...