4IECA

Cys105 covalent modification by 2-hydroxyethyl disulfide in mycobacterium tuberculosis methionine aminopeptidase type 1c
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
280
Chain Sequence
b'RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Methionine aminopeptidase 2
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 86
structure length 280
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4iecA01
2GG3A 2GU5A 4A6VA 3MR1A 5D6EA 4R60A 4U6JA 1O0XA 2BHCA 2BH3A 4IDYA 4PNCA 2ADUA 4FLIA 4IKTA 5CDVA 3BIPA 3CB6A 2GTXA 2EVOA 2EA4A 1KQ9A 1R5HA 4EGEA 2GZ5A 4IF7A 5CE6A 2BN7A 4OOKA 4U73A 2B3KA 1QXWA 5E5BA 4FLKA 4FO7A 1M35A 4JUQA 3S6BA 2BHBA 4QR8A 2GA2A 2NQ7A 1B59A 5JFRA 1QZYA 2GU7A 4IECA 2BHDA 1PV9A 2BWWA 4S2TP 2P99A 3RVAA 2HOWA 2GG5A 3FM3A 2B3HA 4B28A 2BWVA 1N51A 2GG9A 1XGMA 2OKNA 5CLSA 1R5GA 4RGZ1 1WL6A 1YJ3A 4FLLA 1KP0A 2G6PA 1XGSA 3MATA 1WKMA 2GGCA 2Q93A 2BWXA 3CTZA 2EA2A 3PKEA 1Y1NA 1W2MA 1YW9A 4FLJA 3IU8A 4FO8A 3IU9A 4FUKA 2B3LA 3PKAA 4U6EA 1YW8A 3PKDA 2Q94A 4RZZA 1WY2A 1R58A 1C22A 1XGOA 2MATA 2BWYA 4U6CA 4U71A 5CDEA 2OAZA 5FCHA 3IG4A 4Z7MA 4HXXA 5JHUA 4U6ZA 3TB5A 5JI6A 4U70A 2Q96A 1B6AA 3CB5A 1QXYA 2V3ZA 3RORA 5FCFA 5CDLA 4KM3A 4S01A 2Q92A 1BOAA 3PKCA 1WL9A 3FMQA 2GG2A 1YW7A 4A6WA 1C27A 4ZWPA 1C24A 1XNZA 2BHAA 1WN1A 2BWUA 1JAWA 2GU4A 1KQ0A 3BIQA 4U6WA 3TAVA 2BWTA 1CHMA 4S00A 2GG0A 3L24A 4ZNGA 2GG7A 5CNXA 4U1BA 1WLRA 2GU6A 3Q6DA 4U76A 4ZWUA 1QXZA 3FMRA 2V3XA 4RZYA 1WBQA 5CIKA 2Q95A 4U75A 2EVMA 2BB7A 2DFIA 4IPAA 1BN5A 1W7VA 1YVMA 2V3YA 1XGNA 2BWSA 3PKBA 4ZWOA 2Q8KA 2GG8A 2EVCA 4IKSA 3BITA 4MATA 1A16A 4PV4A 2P98A 2V6CA 5D6FA 2IW2A 2P9AA 4IKUA 4FKCA 2ZSGA 4IKRA 4IU6A 4U69A 2GGBA 3D27A 4S2RP 1C21A 2NQ6A 1C23A 3MX6A 1MATA 3IU7A 3L7GA
chains in the Genus database with same CATH superfamily
2GG3A 2GU5A 4A6VA 3MR1A 5D6EA 4R60A 4U6JA 1O0XA 2BHCA 2BH3A 4IDYA 4PNCA 2ADUA 4FLIA 4IKTA 5CDVA 3BIPA 3CB6A 2GTXA 2EVOA 2EA4A 1KQ9A 1R5HA 4EGEA 2GZ5A 4IF7A 5CE6A 2BN7A 4OOKA 4U73A 2B3KA 1QXWA 5E5BA 4FLKA 4FO7A 1M35A 4JUQA 3S6BA 2BHBA 4QR8A 2GA2A 2NQ7A 1B59A 5JFRA 1QZYA 2GU7A 4IECA 2BHDA 1PV9A 2BWWA 4S2TP 2P99A 3RVAA 2HOWA 2GG5A 3FM3A 2B3HA 4B28A 2BWVA 1N51A 2GG9A 1XGMA 2OKNA 5CLSA 1R5GA 4RGZ1 1WL6A 1YJ3A 4FLLA 1KP0A 2G6PA 1XGSA 3MATA 1WKMA 2GGCA 2Q93A 2BWXA 3CTZA 2EA2A 3PKEA 1Y1NA 1W2MA 1YW9A 4FLJA 3IU8A 4FO8A 3IU9A 4FUKA 2B3LA 3PKAA 4U6EA 1YW8A 3PKDA 2Q94A 4RZZA 1WY2A 1R58A 1C22A 1XGOA 2MATA 2BWYA 4U6CA 4U71A 5CDEA 2OAZA 5FCHA 3IG4A 4Z7MA 4HXXA 5JHUA 4U6ZA 3TB5A 5JI6A 4U70A 2Q96A 1B6AA 3CB5A 1QXYA 2V3ZA 3RORA 5FCFA 5CDLA 4KM3A 4S01A 2Q92A 1BOAA 3PKCA 1WL9A 3FMQA 2GG2A 1YW7A 4A6WA 1C27A 4ZWPA 1C24A 1XNZA 2BHAA 1WN1A 2BWUA 1JAWA 2GU4A 1KQ0A 3BIQA 4U6WA 3TAVA 2BWTA 1CHMA 4S00A 2GG0A 3L24A 4ZNGA 2GG7A 5CNXA 4U1BA 1WLRA 2GU6A 3Q6DA 4U76A 4ZWUA 1QXZA 3FMRA 2V3XA 4RZYA 1WBQA 5CIKA 2Q95A 4U75A 2EVMA 2BB7A 2DFIA 4IPAA 1BN5A 1W7VA 1YVMA 2V3YA 1XGNA 2BWSA 3PKBA 4ZWOA 2Q8KA 2GG8A 2EVCA 4IKSA 3BITA 4MATA 1A16A 4PV4A 2P98A 2V6CA 5D6FA 2IW2A 2P9AA 4IKUA 4FKCA 2ZSGA 4IKRA 4IU6A 4U69A 2GGBA 3D27A 4S2RP 1C21A 2NQ6A 1C23A 3MX6A 1MATA 3IU7A 3L7GA
chains in the Genus database with same CATH topology
2GG3A 2GU5A 4A6VA 3MR1A 5D6EA 4R60A 4U6JA 1O0XA 2BHCA 2BH3A 4IDYA 4PNCA 2ADUA 4FLIA 4IKTA 5CDVA 3BIPA 3CB6A 2GTXA 2EVOA 2EA4A 1KQ9A 1R5HA 4EGEA 2GZ5A 4IF7A 5CE6A 2BN7A 4OOKA 4U73A 2B3KA 1QXWA 5E5BA 4FLKA 4FO7A 1M35A 4JUQA 3S6BA 2BHBA 4QR8A 2GA2A 2NQ7A 1B59A 5JFRA 1QZYA 2GU7A 4IECA 2BHDA 1PV9A 2BWWA 4S2TP 2P99A 3RVAA 2HOWA 2GG5A 3FM3A 2B3HA 4B28A 2BWVA 1N51A 2GG9A 1XGMA 2OKNA 5CLSA 1R5GA 4RGZ1 1WL6A 1YJ3A 4FLLA 1KP0A 2G6PA 1XGSA 3MATA 1WKMA 2GGCA 2Q93A 2BWXA 3CTZA 2EA2A 3PKEA 1Y1NA 1W2MA 1YW9A 4FLJA 3IU8A 4FO8A 3IU9A 4FUKA 2B3LA 3PKAA 4U6EA 1YW8A 3PKDA 2Q94A 4RZZA 1WY2A 1R58A 1C22A 1XGOA 2MATA 2BWYA 4U6CA 4U71A 5CDEA 2OAZA 5FCHA 3IG4A 4Z7MA 4HXXA 5JHUA 4U6ZA 3TB5A 5JI6A 4U70A 2Q96A 1B6AA 3CB5A 1QXYA 2V3ZA 3RORA 5FCFA 5CDLA 4KM3A 4S01A 2Q92A 1BOAA 3PKCA 1WL9A 3FMQA 2GG2A 1YW7A 4A6WA 1C27A 4ZWPA 1C24A 1XNZA 2BHAA 1WN1A 2BWUA 1JAWA 2GU4A 1KQ0A 3BIQA 4U6WA 3TAVA 2BWTA 1CHMA 4S00A 2GG0A 3L24A 4ZNGA 2GG7A 5CNXA 4U1BA 1WLRA 2GU6A 3Q6DA 4U76A 4ZWUA 1QXZA 3FMRA 2V3XA 4RZYA 1WBQA 5CIKA 2Q95A 4U75A 2EVMA 2BB7A 2DFIA 4IPAA 1BN5A 1W7VA 1YVMA 2V3YA 1XGNA 2BWSA 3PKBA 4ZWOA 2Q8KA 2GG8A 2EVCA 4IKSA 3BITA 4MATA 1A16A 4PV4A 2P98A 2V6CA 5D6FA 2IW2A 2P9AA 4IKUA 4FKCA 2ZSGA 4IKRA 4IU6A 4U69A 2GGBA 3D27A 4S2RP 1C21A 2NQ6A 1C23A 3MX6A 1MATA 3IU7A 3L7GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GG3 A;  2GU5 A;  4A6V A;  3MR1 A;  5D6E A;  4R60 A;  4U6J A;  1O0X A;  2BHC A;  2BH3 A;  4IDY A;  4PNC A;  2ADU A;  4FLI A;  4IKT A;  5CDV A;  3BIP A;  3CB6 A;  2GTX A;  2EVO A;  2EA4 A;  1KQ9 A;  1R5H A;  4EGE A;  2GZ5 A;  4IF7 A;  5CE6 A;  2BN7 A;  4OOK A;  4U73 A;  2B3K A;  1QXW A;  5E5B A;  4FLK A;  4FO7 A;  1M35 A;  4JUQ A;  3S6B A;  2BHB A;  4QR8 A;  2GA2 A;  2NQ7 A;  1B59 A;  5JFR A;  1QZY A;  2GU7 A;  4IEC A;  2BHD A;  1PV9 A;  2BWW A;  4S2T P;  2P99 A;  3RVA A;  2HOW A;  2GG5 A;  3FM3 A;  2B3H A;  4B28 A;  2BWV A;  1N51 A;  2GG9 A;  1XGM A;  2OKN A;  5CLS A;  1R5G A;  4RGZ 1;  1WL6 A;  1YJ3 A;  4FLL A;  1KP0 A;  2G6P A;  1XGS A;  3MAT A;  1WKM A;  2GGC A;  2Q93 A;  2BWX A;  3CTZ A;  2EA2 A;  3PKE A;  1Y1N A;  1W2M A;  1YW9 A;  4FLJ A;  3IU8 A;  4FO8 A;  3IU9 A;  4FUK A;  2B3L A;  3PKA A;  4U6E A;  1YW8 A;  3PKD A;  2Q94 A;  4RZZ A;  1WY2 A;  1R58 A;  1C22 A;  1XGO A;  2MAT A;  2BWY A;  4U6C A;  4U71 A;  5CDE A;  2OAZ A;  5FCH A;  3IG4 A;  4Z7M A;  4HXX A;  5JHU A;  4U6Z A;  3TB5 A;  5JI6 A;  4U70 A;  2Q96 A;  1B6A A;  3CB5 A;  1QXY A;  2V3Z A;  3ROR A;  5FCF A;  5CDL A;  4KM3 A;  4S01 A;  2Q92 A;  1BOA A;  3PKC A;  1WL9 A;  3FMQ A;  2GG2 A;  1YW7 A;  4A6W A;  1C27 A;  4ZWP A;  1C24 A;  1XNZ A;  2BHA A;  1WN1 A;  2BWU A;  1JAW A;  2GU4 A;  1KQ0 A;  3BIQ A;  4U6W A;  3TAV A;  2BWT A;  1CHM A;  4S00 A;  2GG0 A;  3L24 A;  4ZNG A;  2GG7 A;  5CNX A;  4U1B A;  1WLR A;  2GU6 A;  3Q6D A;  4U76 A;  4ZWU A;  1QXZ A;  3FMR A;  2V3X A;  4RZY A;  1WBQ A;  5CIK A;  2Q95 A;  4U75 A;  2EVM A;  2BB7 A;  2DFI A;  4IPA A;  1BN5 A;  1W7V A;  1YVM A;  2V3Y A;  1XGN A;  2BWS A;  3PKB A;  4ZWO A;  2Q8K A;  2GG8 A;  2EVC A;  4IKS A;  3BIT A;  4MAT A;  1A16 A;  4PV4 A;  2P98 A;  2V6C A;  5D6F A;  2IW2 A;  2P9A A;  4IKU A;  4FKC A;  2ZSG A;  4IKR A;  4IU6 A;  4U69 A;  2GGB A;  3D27 A;  4S2R P;  1C21 A;  2NQ6 A;  1C23 A;  3MX6 A;  1MAT A;  3IU7 A;  3L7G A; 
#chains in the Genus database with same CATH topology
 2GG3 A;  2GU5 A;  4A6V A;  3MR1 A;  5D6E A;  4R60 A;  4U6J A;  1O0X A;  2BHC A;  2BH3 A;  4IDY A;  4PNC A;  2ADU A;  4FLI A;  4IKT A;  5CDV A;  3BIP A;  3CB6 A;  2GTX A;  2EVO A;  2EA4 A;  1KQ9 A;  1R5H A;  4EGE A;  2GZ5 A;  4IF7 A;  5CE6 A;  2BN7 A;  4OOK A;  4U73 A;  2B3K A;  1QXW A;  5E5B A;  4FLK A;  4FO7 A;  1M35 A;  4JUQ A;  3S6B A;  2BHB A;  4QR8 A;  2GA2 A;  2NQ7 A;  1B59 A;  5JFR A;  1QZY A;  2GU7 A;  4IEC A;  2BHD A;  1PV9 A;  2BWW A;  4S2T P;  2P99 A;  3RVA A;  2HOW A;  2GG5 A;  3FM3 A;  2B3H A;  4B28 A;  2BWV A;  1N51 A;  2GG9 A;  1XGM A;  2OKN A;  5CLS A;  1R5G A;  4RGZ 1;  1WL6 A;  1YJ3 A;  4FLL A;  1KP0 A;  2G6P A;  1XGS A;  3MAT A;  1WKM A;  2GGC A;  2Q93 A;  2BWX A;  3CTZ A;  2EA2 A;  3PKE A;  1Y1N A;  1W2M A;  1YW9 A;  4FLJ A;  3IU8 A;  4FO8 A;  3IU9 A;  4FUK A;  2B3L A;  3PKA A;  4U6E A;  1YW8 A;  3PKD A;  2Q94 A;  4RZZ A;  1WY2 A;  1R58 A;  1C22 A;  1XGO A;  2MAT A;  2BWY A;  4U6C A;  4U71 A;  5CDE A;  2OAZ A;  5FCH A;  3IG4 A;  4Z7M A;  4HXX A;  5JHU A;  4U6Z A;  3TB5 A;  5JI6 A;  4U70 A;  2Q96 A;  1B6A A;  3CB5 A;  1QXY A;  2V3Z A;  3ROR A;  5FCF A;  5CDL A;  4KM3 A;  4S01 A;  2Q92 A;  1BOA A;  3PKC A;  1WL9 A;  3FMQ A;  2GG2 A;  1YW7 A;  4A6W A;  1C27 A;  4ZWP A;  1C24 A;  1XNZ A;  2BHA A;  1WN1 A;  2BWU A;  1JAW A;  2GU4 A;  1KQ0 A;  3BIQ A;  4U6W A;  3TAV A;  2BWT A;  1CHM A;  4S00 A;  2GG0 A;  3L24 A;  4ZNG A;  2GG7 A;  5CNX A;  4U1B A;  1WLR A;  2GU6 A;  3Q6D A;  4U76 A;  4ZWU A;  1QXZ A;  3FMR A;  2V3X A;  4RZY A;  1WBQ A;  5CIK A;  2Q95 A;  4U75 A;  2EVM A;  2BB7 A;  2DFI A;  4IPA A;  1BN5 A;  1W7V A;  1YVM A;  2V3Y A;  1XGN A;  2BWS A;  3PKB A;  4ZWO A;  2Q8K A;  2GG8 A;  2EVC A;  4IKS A;  3BIT A;  4MAT A;  1A16 A;  4PV4 A;  2P98 A;  2V6C A;  5D6F A;  2IW2 A;  2P9A A;  4IKU A;  4FKC A;  2ZSG A;  4IKR A;  4IU6 A;  4U69 A;  2GGB A;  3D27 A;  4S2R P;  1C21 A;  2NQ6 A;  1C23 A;  3MX6 A;  1MAT A;  3IU7 A;  3L7G A; 
#chains in the Genus database with same CATH homology
 2GG3 A;  2GU5 A;  4A6V A;  3MR1 A;  5D6E A;  4R60 A;  4U6J A;  1O0X A;  2BHC A;  2BH3 A;  4IDY A;  4PNC A;  2ADU A;  4FLI A;  4IKT A;  5CDV A;  3BIP A;  3CB6 A;  2GTX A;  2EVO A;  2EA4 A;  1KQ9 A;  1R5H A;  4EGE A;  2GZ5 A;  4IF7 A;  5CE6 A;  2BN7 A;  4OOK A;  4U73 A;  2B3K A;  1QXW A;  5E5B A;  4FLK A;  4FO7 A;  1M35 A;  4JUQ A;  3S6B A;  2BHB A;  4QR8 A;  2GA2 A;  2NQ7 A;  1B59 A;  5JFR A;  1QZY A;  2GU7 A;  4IEC A;  2BHD A;  1PV9 A;  2BWW A;  4S2T P;  2P99 A;  3RVA A;  2HOW A;  2GG5 A;  3FM3 A;  2B3H A;  4B28 A;  2BWV A;  1N51 A;  2GG9 A;  1XGM A;  2OKN A;  5CLS A;  1R5G A;  4RGZ 1;  1WL6 A;  1YJ3 A;  4FLL A;  1KP0 A;  2G6P A;  1XGS A;  3MAT A;  1WKM A;  2GGC A;  2Q93 A;  2BWX A;  3CTZ A;  2EA2 A;  3PKE A;  1Y1N A;  1W2M A;  1YW9 A;  4FLJ A;  3IU8 A;  4FO8 A;  3IU9 A;  4FUK A;  2B3L A;  3PKA A;  4U6E A;  1YW8 A;  3PKD A;  2Q94 A;  4RZZ A;  1WY2 A;  1R58 A;  1C22 A;  1XGO A;  2MAT A;  2BWY A;  4U6C A;  4U71 A;  5CDE A;  2OAZ A;  5FCH A;  3IG4 A;  4Z7M A;  4HXX A;  5JHU A;  4U6Z A;  3TB5 A;  5JI6 A;  4U70 A;  2Q96 A;  1B6A A;  3CB5 A;  1QXY A;  2V3Z A;  3ROR A;  5FCF A;  5CDL A;  4KM3 A;  4S01 A;  2Q92 A;  1BOA A;  3PKC A;  1WL9 A;  3FMQ A;  2GG2 A;  1YW7 A;  4A6W A;  1C27 A;  4ZWP A;  1C24 A;  1XNZ A;  2BHA A;  1WN1 A;  2BWU A;  1JAW A;  2GU4 A;  1KQ0 A;  3BIQ A;  4U6W A;  3TAV A;  2BWT A;  1CHM A;  4S00 A;  2GG0 A;  3L24 A;  4ZNG A;  2GG7 A;  5CNX A;  4U1B A;  1WLR A;  2GU6 A;  3Q6D A;  4U76 A;  4ZWU A;  1QXZ A;  3FMR A;  2V3X A;  4RZY A;  1WBQ A;  5CIK A;  2Q95 A;  4U75 A;  2EVM A;  2BB7 A;  2DFI A;  4IPA A;  1BN5 A;  1W7V A;  1YVM A;  2V3Y A;  1XGN A;  2BWS A;  3PKB A;  4ZWO A;  2Q8K A;  2GG8 A;  2EVC A;  4IKS A;  3BIT A;  4MAT A;  1A16 A;  4PV4 A;  2P98 A;  2V6C A;  5D6F A;  2IW2 A;  2P9A A;  4IKU A;  4FKC A;  2ZSG A;  4IKR A;  4IU6 A;  4U69 A;  2GGB A;  3D27 A;  4S2R P;  1C21 A;  2NQ6 A;  1C23 A;  3MX6 A;  1MAT A;  3IU7 A;  3L7G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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