2GG5A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 81
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg5A00
2BHDA 5FCFA 1O0XA 2GGCA 3IU9A 4IPAA 1C22A 5D6FA 4U71A 2BWSA 2BH3A 4U76A 3BIPA 4IU6A 4Z7MA 4U70A 1W2MA 1YW8A 3BIQA 2EVMA 2P9AA 1MATA 4OOKA 5FCHA 1KQ0A 1WKMA 4U75A 1B59A 4MATA 1BN5A 4FLLA 4S2TP 2V3ZA 4KM3A 2V3XA 2GU5A 1CHMA 1XGOA 2GG8A 1QZYA 3CB5A 2P98A 4A6WA 5CDVA 1C23A 4RZYA 3RVAA 1R5GA 2BHCA 3PKAA 3MATA 4U1BA 1C24A 2GA2A 1XGMA 4U6WA 2GG3A 5CLSA 1QXWA 2BWXA 2OKNA 2B3KA 2MATA 1Y1NA 4FLJA 5JI6A 1C27A 2GTXA 1WY2A 1YJ3A 4IF7A 4ZWOA 5D6EA 2BWWA 1XGSA 3Q6DA 3D27A 1YW7A 3IU8A 4U73A 1M35A 5E5BA 4FLKA 2Q95A 1W7VA 2GG0A 2NQ6A 3FM3A 4FKCA 4U6CA 5CNXA 2NQ7A 3TB5A 5JHUA 3S6BA 4ZNGA 3PKDA 3FMQA 5CIKA 1KQ9A 3L7GA 2BB7A 1QXZA 2GU6A 3PKBA 1WN1A 4U6ZA 3CB6A 5CDEA 4EGEA 2BHAA 4R60A 2BWYA 3BITA 2B3LA 2EVCA 4IECA 1WL6A 1N51A 4ZWPA 5CE6A 3MX6A 2BHBA 1WLRA 2Q93A 3IG4A 1XGNA 3PKCA 1PV9A 1YW9A 4IKRA 1YVMA 2GU4A 2Q96A 4A6VA 3PKEA 3L24A 2GG7A 2Q92A 1WL9A 2ADUA 1B6AA 4HXXA 5JFRA 2Q94A 1WBQA 2EA4A 1JAWA 1R5HA 1QXYA 2V3YA 4U6JA 2GG9A 4RGZ1 2HOWA 3IU7A 4FUKA 2DFIA 2B3HA 4IKUA 4JUQA 1KP0A 4FO8A 4S2RP 2OAZA 4FO7A 2G6PA 1R58A 3CTZA 2EA2A 3RORA 4IDYA 4U6EA 3FMRA 4RZZA 2IW2A 1C21A 2GGBA 4FLIA 4B28A 4S01A 2V6CA 4IKTA 2BWVA 2BWTA 4PV4A 2ZSGA 4U69A 1BOAA 2GU7A 2GZ5A 2GG5A 2BWUA 4ZWUA 2BN7A 5CDLA 4PNCA 2P99A 2Q8KA 2GG2A 3MR1A 3TAVA 2EVOA 1A16A 4IKSA 1XNZA 4QR8A 4S00A
chains in the Genus database with same CATH superfamily
2BHDA 5FCFA 1O0XA 2GGCA 3IU9A 4IPAA 1C22A 5D6FA 4U71A 2BWSA 2BH3A 4U76A 3BIPA 4IU6A 4Z7MA 4U70A 1W2MA 1YW8A 3BIQA 2EVMA 2P9AA 1MATA 4OOKA 5FCHA 1KQ0A 1WKMA 4U75A 1B59A 4MATA 1BN5A 4FLLA 4S2TP 2V3ZA 4KM3A 2V3XA 2GU5A 1CHMA 1XGOA 2GG8A 1QZYA 3CB5A 2P98A 4A6WA 5CDVA 1C23A 4RZYA 3RVAA 1R5GA 2BHCA 3PKAA 3MATA 4U1BA 1C24A 2GA2A 1XGMA 4U6WA 2GG3A 5CLSA 1QXWA 2BWXA 2OKNA 2B3KA 2MATA 1Y1NA 4FLJA 5JI6A 1C27A 2GTXA 1WY2A 1YJ3A 4IF7A 4ZWOA 5D6EA 2BWWA 1XGSA 3Q6DA 3D27A 1YW7A 3IU8A 4U73A 1M35A 5E5BA 4FLKA 2Q95A 1W7VA 2GG0A 2NQ6A 3FM3A 4FKCA 4U6CA 5CNXA 2NQ7A 3TB5A 5JHUA 3S6BA 4ZNGA 3PKDA 3FMQA 5CIKA 1KQ9A 3L7GA 2BB7A 1QXZA 2GU6A 3PKBA 1WN1A 4U6ZA 3CB6A 5CDEA 4EGEA 2BHAA 4R60A 2BWYA 3BITA 2B3LA 2EVCA 4IECA 1WL6A 1N51A 4ZWPA 5CE6A 3MX6A 2BHBA 1WLRA 2Q93A 3IG4A 1XGNA 3PKCA 1PV9A 1YW9A 4IKRA 1YVMA 2GU4A 2Q96A 4A6VA 3PKEA 3L24A 2GG7A 2Q92A 1WL9A 2ADUA 1B6AA 4HXXA 5JFRA 2Q94A 1WBQA 2EA4A 1JAWA 1R5HA 1QXYA 2V3YA 4U6JA 2GG9A 4RGZ1 2HOWA 3IU7A 4FUKA 2DFIA 2B3HA 4IKUA 4JUQA 1KP0A 4FO8A 4S2RP 2OAZA 4FO7A 2G6PA 1R58A 3CTZA 2EA2A 3RORA 4IDYA 4U6EA 3FMRA 4RZZA 2IW2A 1C21A 2GGBA 4FLIA 4B28A 4S01A 2V6CA 4IKTA 2BWVA 2BWTA 4PV4A 2ZSGA 4U69A 1BOAA 2GU7A 2GZ5A 2GG5A 2BWUA 4ZWUA 2BN7A 5CDLA 4PNCA 2P99A 2Q8KA 2GG2A 3MR1A 3TAVA 2EVOA 1A16A 4IKSA 1XNZA 4QR8A 4S00A
chains in the Genus database with same CATH topology
2BHDA 5FCFA 1O0XA 2GGCA 3IU9A 4IPAA 1C22A 5D6FA 4U71A 2BWSA 2BH3A 4U76A 3BIPA 4IU6A 4Z7MA 4U70A 1W2MA 1YW8A 3BIQA 2EVMA 2P9AA 1MATA 4OOKA 5FCHA 1KQ0A 1WKMA 4U75A 1B59A 4MATA 1BN5A 4FLLA 4S2TP 2V3ZA 4KM3A 2V3XA 2GU5A 1CHMA 1XGOA 2GG8A 1QZYA 3CB5A 2P98A 4A6WA 5CDVA 1C23A 4RZYA 3RVAA 1R5GA 2BHCA 3PKAA 3MATA 4U1BA 1C24A 2GA2A 1XGMA 4U6WA 2GG3A 5CLSA 1QXWA 2BWXA 2OKNA 2B3KA 2MATA 1Y1NA 4FLJA 5JI6A 1C27A 2GTXA 1WY2A 1YJ3A 4IF7A 4ZWOA 5D6EA 2BWWA 1XGSA 3Q6DA 3D27A 1YW7A 3IU8A 4U73A 1M35A 5E5BA 4FLKA 2Q95A 1W7VA 2GG0A 2NQ6A 3FM3A 4FKCA 4U6CA 5CNXA 2NQ7A 3TB5A 5JHUA 3S6BA 4ZNGA 3PKDA 3FMQA 5CIKA 1KQ9A 3L7GA 2BB7A 1QXZA 2GU6A 3PKBA 1WN1A 4U6ZA 3CB6A 5CDEA 4EGEA 2BHAA 4R60A 2BWYA 3BITA 2B3LA 2EVCA 4IECA 1WL6A 1N51A 4ZWPA 5CE6A 3MX6A 2BHBA 1WLRA 2Q93A 3IG4A 1XGNA 3PKCA 1PV9A 1YW9A 4IKRA 1YVMA 2GU4A 2Q96A 4A6VA 3PKEA 3L24A 2GG7A 2Q92A 1WL9A 2ADUA 1B6AA 4HXXA 5JFRA 2Q94A 1WBQA 2EA4A 1JAWA 1R5HA 1QXYA 2V3YA 4U6JA 2GG9A 4RGZ1 2HOWA 3IU7A 4FUKA 2DFIA 2B3HA 4IKUA 4JUQA 1KP0A 4FO8A 4S2RP 2OAZA 4FO7A 2G6PA 1R58A 3CTZA 2EA2A 3RORA 4IDYA 4U6EA 3FMRA 4RZZA 2IW2A 1C21A 2GGBA 4FLIA 4B28A 4S01A 2V6CA 4IKTA 2BWVA 2BWTA 4PV4A 2ZSGA 4U69A 1BOAA 2GU7A 2GZ5A 2GG5A 2BWUA 4ZWUA 2BN7A 5CDLA 4PNCA 2P99A 2Q8KA 2GG2A 3MR1A 3TAVA 2EVOA 1A16A 4IKSA 1XNZA 4QR8A 4S00A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BHD A;  5FCF A;  1O0X A;  2GGC A;  3IU9 A;  4IPA A;  1C22 A;  5D6F A;  4U71 A;  2BWS A;  2BH3 A;  4U76 A;  3BIP A;  4IU6 A;  4Z7M A;  4U70 A;  1W2M A;  1YW8 A;  3BIQ A;  2EVM A;  2P9A A;  1MAT A;  4OOK A;  5FCH A;  1KQ0 A;  1WKM A;  4U75 A;  1B59 A;  4MAT A;  1BN5 A;  4FLL A;  4S2T P;  2V3Z A;  4KM3 A;  2V3X A;  2GU5 A;  1CHM A;  1XGO A;  2GG8 A;  1QZY A;  3CB5 A;  2P98 A;  4A6W A;  5CDV A;  1C23 A;  4RZY A;  3RVA A;  1R5G A;  2BHC A;  3PKA A;  3MAT A;  4U1B A;  1C24 A;  2GA2 A;  1XGM A;  4U6W A;  2GG3 A;  5CLS A;  1QXW A;  2BWX A;  2OKN A;  2B3K A;  2MAT A;  1Y1N A;  4FLJ A;  5JI6 A;  1C27 A;  2GTX A;  1WY2 A;  1YJ3 A;  4IF7 A;  4ZWO A;  5D6E A;  2BWW A;  1XGS A;  3Q6D A;  3D27 A;  1YW7 A;  3IU8 A;  4U73 A;  1M35 A;  5E5B A;  4FLK A;  2Q95 A;  1W7V A;  2GG0 A;  2NQ6 A;  3FM3 A;  4FKC A;  4U6C A;  5CNX A;  2NQ7 A;  3TB5 A;  5JHU A;  3S6B A;  4ZNG A;  3PKD A;  3FMQ A;  5CIK A;  1KQ9 A;  3L7G A;  2BB7 A;  1QXZ A;  2GU6 A;  3PKB A;  1WN1 A;  4U6Z A;  3CB6 A;  5CDE A;  4EGE A;  2BHA A;  4R60 A;  2BWY A;  3BIT A;  2B3L A;  2EVC A;  4IEC A;  1WL6 A;  1N51 A;  4ZWP A;  5CE6 A;  3MX6 A;  2BHB A;  1WLR A;  2Q93 A;  3IG4 A;  1XGN A;  3PKC A;  1PV9 A;  1YW9 A;  4IKR A;  1YVM A;  2GU4 A;  2Q96 A;  4A6V A;  3PKE A;  3L24 A;  2GG7 A;  2Q92 A;  1WL9 A;  2ADU A;  1B6A A;  4HXX A;  5JFR A;  2Q94 A;  1WBQ A;  2EA4 A;  1JAW A;  1R5H A;  1QXY A;  2V3Y A;  4U6J A;  2GG9 A;  4RGZ 1;  2HOW A;  3IU7 A;  4FUK A;  2DFI A;  2B3H A;  4IKU A;  4JUQ A;  1KP0 A;  4FO8 A;  4S2R P;  2OAZ A;  4FO7 A;  2G6P A;  1R58 A;  3CTZ A;  2EA2 A;  3ROR A;  4IDY A;  4U6E A;  3FMR A;  4RZZ A;  2IW2 A;  1C21 A;  2GGB A;  4FLI A;  4B28 A;  4S01 A;  2V6C A;  4IKT A;  2BWV A;  2BWT A;  4PV4 A;  2ZSG A;  4U69 A;  1BOA A;  2GU7 A;  2GZ5 A;  2GG5 A;  2BWU A;  4ZWU A;  2BN7 A;  5CDL A;  4PNC A;  2P99 A;  2Q8K A;  2GG2 A;  3MR1 A;  3TAV A;  2EVO A;  1A16 A;  4IKS A;  1XNZ A;  4QR8 A;  4S00 A; 
#chains in the Genus database with same CATH topology
 2BHD A;  5FCF A;  1O0X A;  2GGC A;  3IU9 A;  4IPA A;  1C22 A;  5D6F A;  4U71 A;  2BWS A;  2BH3 A;  4U76 A;  3BIP A;  4IU6 A;  4Z7M A;  4U70 A;  1W2M A;  1YW8 A;  3BIQ A;  2EVM A;  2P9A A;  1MAT A;  4OOK A;  5FCH A;  1KQ0 A;  1WKM A;  4U75 A;  1B59 A;  4MAT A;  1BN5 A;  4FLL A;  4S2T P;  2V3Z A;  4KM3 A;  2V3X A;  2GU5 A;  1CHM A;  1XGO A;  2GG8 A;  1QZY A;  3CB5 A;  2P98 A;  4A6W A;  5CDV A;  1C23 A;  4RZY A;  3RVA A;  1R5G A;  2BHC A;  3PKA A;  3MAT A;  4U1B A;  1C24 A;  2GA2 A;  1XGM A;  4U6W A;  2GG3 A;  5CLS A;  1QXW A;  2BWX A;  2OKN A;  2B3K A;  2MAT A;  1Y1N A;  4FLJ A;  5JI6 A;  1C27 A;  2GTX A;  1WY2 A;  1YJ3 A;  4IF7 A;  4ZWO A;  5D6E A;  2BWW A;  1XGS A;  3Q6D A;  3D27 A;  1YW7 A;  3IU8 A;  4U73 A;  1M35 A;  5E5B A;  4FLK A;  2Q95 A;  1W7V A;  2GG0 A;  2NQ6 A;  3FM3 A;  4FKC A;  4U6C A;  5CNX A;  2NQ7 A;  3TB5 A;  5JHU A;  3S6B A;  4ZNG A;  3PKD A;  3FMQ A;  5CIK A;  1KQ9 A;  3L7G A;  2BB7 A;  1QXZ A;  2GU6 A;  3PKB A;  1WN1 A;  4U6Z A;  3CB6 A;  5CDE A;  4EGE A;  2BHA A;  4R60 A;  2BWY A;  3BIT A;  2B3L A;  2EVC A;  4IEC A;  1WL6 A;  1N51 A;  4ZWP A;  5CE6 A;  3MX6 A;  2BHB A;  1WLR A;  2Q93 A;  3IG4 A;  1XGN A;  3PKC A;  1PV9 A;  1YW9 A;  4IKR A;  1YVM A;  2GU4 A;  2Q96 A;  4A6V A;  3PKE A;  3L24 A;  2GG7 A;  2Q92 A;  1WL9 A;  2ADU A;  1B6A A;  4HXX A;  5JFR A;  2Q94 A;  1WBQ A;  2EA4 A;  1JAW A;  1R5H A;  1QXY A;  2V3Y A;  4U6J A;  2GG9 A;  4RGZ 1;  2HOW A;  3IU7 A;  4FUK A;  2DFI A;  2B3H A;  4IKU A;  4JUQ A;  1KP0 A;  4FO8 A;  4S2R P;  2OAZ A;  4FO7 A;  2G6P A;  1R58 A;  3CTZ A;  2EA2 A;  3ROR A;  4IDY A;  4U6E A;  3FMR A;  4RZZ A;  2IW2 A;  1C21 A;  2GGB A;  4FLI A;  4B28 A;  4S01 A;  2V6C A;  4IKT A;  2BWV A;  2BWT A;  4PV4 A;  2ZSG A;  4U69 A;  1BOA A;  2GU7 A;  2GZ5 A;  2GG5 A;  2BWU A;  4ZWU A;  2BN7 A;  5CDL A;  4PNC A;  2P99 A;  2Q8K A;  2GG2 A;  3MR1 A;  3TAV A;  2EVO A;  1A16 A;  4IKS A;  1XNZ A;  4QR8 A;  4S00 A; 
#chains in the Genus database with same CATH homology
 2BHD A;  5FCF A;  1O0X A;  2GGC A;  3IU9 A;  4IPA A;  1C22 A;  5D6F A;  4U71 A;  2BWS A;  2BH3 A;  4U76 A;  3BIP A;  4IU6 A;  4Z7M A;  4U70 A;  1W2M A;  1YW8 A;  3BIQ A;  2EVM A;  2P9A A;  1MAT A;  4OOK A;  5FCH A;  1KQ0 A;  1WKM A;  4U75 A;  1B59 A;  4MAT A;  1BN5 A;  4FLL A;  4S2T P;  2V3Z A;  4KM3 A;  2V3X A;  2GU5 A;  1CHM A;  1XGO A;  2GG8 A;  1QZY A;  3CB5 A;  2P98 A;  4A6W A;  5CDV A;  1C23 A;  4RZY A;  3RVA A;  1R5G A;  2BHC A;  3PKA A;  3MAT A;  4U1B A;  1C24 A;  2GA2 A;  1XGM A;  4U6W A;  2GG3 A;  5CLS A;  1QXW A;  2BWX A;  2OKN A;  2B3K A;  2MAT A;  1Y1N A;  4FLJ A;  5JI6 A;  1C27 A;  2GTX A;  1WY2 A;  1YJ3 A;  4IF7 A;  4ZWO A;  5D6E A;  2BWW A;  1XGS A;  3Q6D A;  3D27 A;  1YW7 A;  3IU8 A;  4U73 A;  1M35 A;  5E5B A;  4FLK A;  2Q95 A;  1W7V A;  2GG0 A;  2NQ6 A;  3FM3 A;  4FKC A;  4U6C A;  5CNX A;  2NQ7 A;  3TB5 A;  5JHU A;  3S6B A;  4ZNG A;  3PKD A;  3FMQ A;  5CIK A;  1KQ9 A;  3L7G A;  2BB7 A;  1QXZ A;  2GU6 A;  3PKB A;  1WN1 A;  4U6Z A;  3CB6 A;  5CDE A;  4EGE A;  2BHA A;  4R60 A;  2BWY A;  3BIT A;  2B3L A;  2EVC A;  4IEC A;  1WL6 A;  1N51 A;  4ZWP A;  5CE6 A;  3MX6 A;  2BHB A;  1WLR A;  2Q93 A;  3IG4 A;  1XGN A;  3PKC A;  1PV9 A;  1YW9 A;  4IKR A;  1YVM A;  2GU4 A;  2Q96 A;  4A6V A;  3PKE A;  3L24 A;  2GG7 A;  2Q92 A;  1WL9 A;  2ADU A;  1B6A A;  4HXX A;  5JFR A;  2Q94 A;  1WBQ A;  2EA4 A;  1JAW A;  1R5H A;  1QXY A;  2V3Y A;  4U6J A;  2GG9 A;  4RGZ 1;  2HOW A;  3IU7 A;  4FUK A;  2DFI A;  2B3H A;  4IKU A;  4JUQ A;  1KP0 A;  4FO8 A;  4S2R P;  2OAZ A;  4FO7 A;  2G6P A;  1R58 A;  3CTZ A;  2EA2 A;  3ROR A;  4IDY A;  4U6E A;  3FMR A;  4RZZ A;  2IW2 A;  1C21 A;  2GGB A;  4FLI A;  4B28 A;  4S01 A;  2V6C A;  4IKT A;  2BWV A;  2BWT A;  4PV4 A;  2ZSG A;  4U69 A;  1BOA A;  2GU7 A;  2GZ5 A;  2GG5 A;  2BWU A;  4ZWU A;  2BN7 A;  5CDL A;  4PNC A;  2P99 A;  2Q8K A;  2GG2 A;  3MR1 A;  3TAV A;  2EVO A;  1A16 A;  4IKS A;  1XNZ A;  4QR8 A;  4S00 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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