4HXXA

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 98
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-11-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4hxxA00
1YW7A 4IPAA 1QXWA 4U70A 1N51A 3FMRA 5E5BA 4RZYA 3TAVA 1WY2A 3L24A 1O0XA 4S2RP 4U71A 4IKRA 5JHUA 2GU7A 1JAWA 1WL9A 2GG7A 4IDYA 1BOAA 5CE6A 1PV9A 5JI6A 2BH3A 2BWSA 4IF7A 1YJ3A 4KM3A 3IU8A 2HOWA 2IW2A 1QXYA 4R60A 2OAZA 4U6JA 2GG0A 2ZSGA 4U76A 5D6FA 1XGOA 2GG9A 2GGBA 4EGEA 2BN7A 1BN5A 2BWUA 2GTXA 5FCHA 5D6EA 4JUQA 2GG5A 3CB5A 1XGSA 1WKMA 1R5HA 1XNZA 3RORA 2EA2A 1W2MA 1R5GA 2GG3A 4PV4A 3L7GA 2BHBA 2P99A 4U73A 2NQ7A 4FO8A 3BIQA 4IKUA 1Y1NA 2V6CA 4U6EA 1M35A 4U1BA 3IU7A 2GGCA 3MATA 4U69A 4S2TP 4FLIA 4FLJA 4U75A 4A6WA 5CDLA 2BHCA 3MX6A 4Z7MA 4B28A 2BHAA 4OOKA 4ZNGA 2V3ZA 3FM3A 3PKEA 3BITA 4A6VA 1QZYA 1XGMA 1YW8A 3PKAA 4FLLA 5JFRA 4ZWPA 3FMQA 2OKNA 4HXXA 1C27A 2Q95A 3BIPA 4RZZA 3CTZA 3S6BA 3PKCA 3CB6A 4IKTA 4FLKA 2Q94A 2GG2A 2ADUA 2BB7A 1XGNA 3IG4A 1YW9A 2BWXA 2P98A 2B3LA 4FKCA 4U6WA 2BHDA 5CDVA 2G6PA 2GG8A 2EA4A 1C21A 1W7VA 4U6CA 2GA2A 2NQ6A 1C23A 1CHMA 3RVAA 1WLRA 3PKBA 2Q8KA 2B3KA 1QXZA 2V3XA 1WL6A 1B6AA 2Q92A 2DFIA 4IU6A 4QR8A 3PKDA 1WN1A 3Q6DA 1A16A 1R58A 1WBQA 1KP0A 4ZWOA 3D27A 3TB5A 4S00A 1C24A 2BWVA 2GU6A 4S01A 1B59A 4IKSA 2B3HA 4ZWUA 2Q93A 1C22A 4IECA 4U6ZA 5CIKA 2P9AA 2EVCA 2GU5A 4RGZ1 3IU9A 2V3YA 4MATA 5CLSA 5CDEA 1YVMA 2BWWA 4FO7A 4FUKA 2MATA 2BWTA 2GU4A 1MATA 1KQ0A 2EVMA 2GZ5A 2Q96A 4PNCA 3MR1A 5FCFA 1KQ9A 5CNXA 2EVOA 2BWYA
chains in the Genus database with same CATH superfamily
1YW7A 4IPAA 1QXWA 4U70A 1N51A 3FMRA 5E5BA 4RZYA 3TAVA 1WY2A 3L24A 1O0XA 4S2RP 4U71A 4IKRA 5JHUA 2GU7A 1JAWA 1WL9A 2GG7A 4IDYA 1BOAA 5CE6A 1PV9A 5JI6A 2BH3A 2BWSA 4IF7A 1YJ3A 4KM3A 3IU8A 2HOWA 2IW2A 1QXYA 4R60A 2OAZA 4U6JA 2GG0A 2ZSGA 4U76A 5D6FA 1XGOA 2GG9A 2GGBA 4EGEA 2BN7A 1BN5A 2BWUA 2GTXA 5FCHA 5D6EA 4JUQA 2GG5A 3CB5A 1XGSA 1WKMA 1R5HA 1XNZA 3RORA 2EA2A 1W2MA 1R5GA 2GG3A 4PV4A 3L7GA 2BHBA 2P99A 4U73A 2NQ7A 4FO8A 3BIQA 4IKUA 1Y1NA 2V6CA 4U6EA 1M35A 4U1BA 3IU7A 2GGCA 3MATA 4U69A 4S2TP 4FLIA 4FLJA 4U75A 4A6WA 5CDLA 2BHCA 3MX6A 4Z7MA 4B28A 2BHAA 4OOKA 4ZNGA 2V3ZA 3FM3A 3PKEA 3BITA 4A6VA 1QZYA 1XGMA 1YW8A 3PKAA 4FLLA 5JFRA 4ZWPA 3FMQA 2OKNA 4HXXA 1C27A 2Q95A 3BIPA 4RZZA 3CTZA 3S6BA 3PKCA 3CB6A 4IKTA 4FLKA 2Q94A 2GG2A 2ADUA 2BB7A 1XGNA 3IG4A 1YW9A 2BWXA 2P98A 2B3LA 4FKCA 4U6WA 2BHDA 5CDVA 2G6PA 2GG8A 2EA4A 1C21A 1W7VA 4U6CA 2GA2A 2NQ6A 1C23A 1CHMA 3RVAA 1WLRA 3PKBA 2Q8KA 2B3KA 1QXZA 2V3XA 1WL6A 1B6AA 2Q92A 2DFIA 4IU6A 4QR8A 3PKDA 1WN1A 3Q6DA 1A16A 1R58A 1WBQA 1KP0A 4ZWOA 3D27A 3TB5A 4S00A 1C24A 2BWVA 2GU6A 4S01A 1B59A 4IKSA 2B3HA 4ZWUA 2Q93A 1C22A 4IECA 4U6ZA 5CIKA 2P9AA 2EVCA 2GU5A 4RGZ1 3IU9A 2V3YA 4MATA 5CLSA 5CDEA 1YVMA 2BWWA 4FO7A 4FUKA 2MATA 2BWTA 2GU4A 1MATA 1KQ0A 2EVMA 2GZ5A 2Q96A 4PNCA 3MR1A 5FCFA 1KQ9A 5CNXA 2EVOA 2BWYA
chains in the Genus database with same CATH topology
1YW7A 4IPAA 1QXWA 4U70A 1N51A 3FMRA 5E5BA 4RZYA 3TAVA 1WY2A 3L24A 1O0XA 4S2RP 4U71A 4IKRA 5JHUA 2GU7A 1JAWA 1WL9A 2GG7A 4IDYA 1BOAA 5CE6A 1PV9A 5JI6A 2BH3A 2BWSA 4IF7A 1YJ3A 4KM3A 3IU8A 2HOWA 2IW2A 1QXYA 4R60A 2OAZA 4U6JA 2GG0A 2ZSGA 4U76A 5D6FA 1XGOA 2GG9A 2GGBA 4EGEA 2BN7A 1BN5A 2BWUA 2GTXA 5FCHA 5D6EA 4JUQA 2GG5A 3CB5A 1XGSA 1WKMA 1R5HA 1XNZA 3RORA 2EA2A 1W2MA 1R5GA 2GG3A 4PV4A 3L7GA 2BHBA 2P99A 4U73A 2NQ7A 4FO8A 3BIQA 4IKUA 1Y1NA 2V6CA 4U6EA 1M35A 4U1BA 3IU7A 2GGCA 3MATA 4U69A 4S2TP 4FLIA 4FLJA 4U75A 4A6WA 5CDLA 2BHCA 3MX6A 4Z7MA 4B28A 2BHAA 4OOKA 4ZNGA 2V3ZA 3FM3A 3PKEA 3BITA 4A6VA 1QZYA 1XGMA 1YW8A 3PKAA 4FLLA 5JFRA 4ZWPA 3FMQA 2OKNA 4HXXA 1C27A 2Q95A 3BIPA 4RZZA 3CTZA 3S6BA 3PKCA 3CB6A 4IKTA 4FLKA 2Q94A 2GG2A 2ADUA 2BB7A 1XGNA 3IG4A 1YW9A 2BWXA 2P98A 2B3LA 4FKCA 4U6WA 2BHDA 5CDVA 2G6PA 2GG8A 2EA4A 1C21A 1W7VA 4U6CA 2GA2A 2NQ6A 1C23A 1CHMA 3RVAA 1WLRA 3PKBA 2Q8KA 2B3KA 1QXZA 2V3XA 1WL6A 1B6AA 2Q92A 2DFIA 4IU6A 4QR8A 3PKDA 1WN1A 3Q6DA 1A16A 1R58A 1WBQA 1KP0A 4ZWOA 3D27A 3TB5A 4S00A 1C24A 2BWVA 2GU6A 4S01A 1B59A 4IKSA 2B3HA 4ZWUA 2Q93A 1C22A 4IECA 4U6ZA 5CIKA 2P9AA 2EVCA 2GU5A 4RGZ1 3IU9A 2V3YA 4MATA 5CLSA 5CDEA 1YVMA 2BWWA 4FO7A 4FUKA 2MATA 2BWTA 2GU4A 1MATA 1KQ0A 2EVMA 2GZ5A 2Q96A 4PNCA 3MR1A 5FCFA 1KQ9A 5CNXA 2EVOA 2BWYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1YW7 A;  4IPA A;  1QXW A;  4U70 A;  1N51 A;  3FMR A;  5E5B A;  4RZY A;  3TAV A;  1WY2 A;  3L24 A;  1O0X A;  4S2R P;  4U71 A;  4IKR A;  5JHU A;  2GU7 A;  1JAW A;  1WL9 A;  2GG7 A;  4IDY A;  1BOA A;  5CE6 A;  1PV9 A;  5JI6 A;  2BH3 A;  2BWS A;  4IF7 A;  1YJ3 A;  4KM3 A;  3IU8 A;  2HOW A;  2IW2 A;  1QXY A;  4R60 A;  2OAZ A;  4U6J A;  2GG0 A;  2ZSG A;  4U76 A;  5D6F A;  1XGO A;  2GG9 A;  2GGB A;  4EGE A;  2BN7 A;  1BN5 A;  2BWU A;  2GTX A;  5FCH A;  5D6E A;  4JUQ A;  2GG5 A;  3CB5 A;  1XGS A;  1WKM A;  1R5H A;  1XNZ A;  3ROR A;  2EA2 A;  1W2M A;  1R5G A;  2GG3 A;  4PV4 A;  3L7G A;  2BHB A;  2P99 A;  4U73 A;  2NQ7 A;  4FO8 A;  3BIQ A;  4IKU A;  1Y1N A;  2V6C A;  4U6E A;  1M35 A;  4U1B A;  3IU7 A;  2GGC A;  3MAT A;  4U69 A;  4S2T P;  4FLI A;  4FLJ A;  4U75 A;  4A6W A;  5CDL A;  2BHC A;  3MX6 A;  4Z7M A;  4B28 A;  2BHA A;  4OOK A;  4ZNG A;  2V3Z A;  3FM3 A;  3PKE A;  3BIT A;  4A6V A;  1QZY A;  1XGM A;  1YW8 A;  3PKA A;  4FLL A;  5JFR A;  4ZWP A;  3FMQ A;  2OKN A;  4HXX A;  1C27 A;  2Q95 A;  3BIP A;  4RZZ A;  3CTZ A;  3S6B A;  3PKC A;  3CB6 A;  4IKT A;  4FLK A;  2Q94 A;  2GG2 A;  2ADU A;  2BB7 A;  1XGN A;  3IG4 A;  1YW9 A;  2BWX A;  2P98 A;  2B3L A;  4FKC A;  4U6W A;  2BHD A;  5CDV A;  2G6P A;  2GG8 A;  2EA4 A;  1C21 A;  1W7V A;  4U6C A;  2GA2 A;  2NQ6 A;  1C23 A;  1CHM A;  3RVA A;  1WLR A;  3PKB A;  2Q8K A;  2B3K A;  1QXZ A;  2V3X A;  1WL6 A;  1B6A A;  2Q92 A;  2DFI A;  4IU6 A;  4QR8 A;  3PKD A;  1WN1 A;  3Q6D A;  1A16 A;  1R58 A;  1WBQ A;  1KP0 A;  4ZWO A;  3D27 A;  3TB5 A;  4S00 A;  1C24 A;  2BWV A;  2GU6 A;  4S01 A;  1B59 A;  4IKS A;  2B3H A;  4ZWU A;  2Q93 A;  1C22 A;  4IEC A;  4U6Z A;  5CIK A;  2P9A A;  2EVC A;  2GU5 A;  4RGZ 1;  3IU9 A;  2V3Y A;  4MAT A;  5CLS A;  5CDE A;  1YVM A;  2BWW A;  4FO7 A;  4FUK A;  2MAT A;  2BWT A;  2GU4 A;  1MAT A;  1KQ0 A;  2EVM A;  2GZ5 A;  2Q96 A;  4PNC A;  3MR1 A;  5FCF A;  1KQ9 A;  5CNX A;  2EVO A;  2BWY A; 
#chains in the Genus database with same CATH topology
 1YW7 A;  4IPA A;  1QXW A;  4U70 A;  1N51 A;  3FMR A;  5E5B A;  4RZY A;  3TAV A;  1WY2 A;  3L24 A;  1O0X A;  4S2R P;  4U71 A;  4IKR A;  5JHU A;  2GU7 A;  1JAW A;  1WL9 A;  2GG7 A;  4IDY A;  1BOA A;  5CE6 A;  1PV9 A;  5JI6 A;  2BH3 A;  2BWS A;  4IF7 A;  1YJ3 A;  4KM3 A;  3IU8 A;  2HOW A;  2IW2 A;  1QXY A;  4R60 A;  2OAZ A;  4U6J A;  2GG0 A;  2ZSG A;  4U76 A;  5D6F A;  1XGO A;  2GG9 A;  2GGB A;  4EGE A;  2BN7 A;  1BN5 A;  2BWU A;  2GTX A;  5FCH A;  5D6E A;  4JUQ A;  2GG5 A;  3CB5 A;  1XGS A;  1WKM A;  1R5H A;  1XNZ A;  3ROR A;  2EA2 A;  1W2M A;  1R5G A;  2GG3 A;  4PV4 A;  3L7G A;  2BHB A;  2P99 A;  4U73 A;  2NQ7 A;  4FO8 A;  3BIQ A;  4IKU A;  1Y1N A;  2V6C A;  4U6E A;  1M35 A;  4U1B A;  3IU7 A;  2GGC A;  3MAT A;  4U69 A;  4S2T P;  4FLI A;  4FLJ A;  4U75 A;  4A6W A;  5CDL A;  2BHC A;  3MX6 A;  4Z7M A;  4B28 A;  2BHA A;  4OOK A;  4ZNG A;  2V3Z A;  3FM3 A;  3PKE A;  3BIT A;  4A6V A;  1QZY A;  1XGM A;  1YW8 A;  3PKA A;  4FLL A;  5JFR A;  4ZWP A;  3FMQ A;  2OKN A;  4HXX A;  1C27 A;  2Q95 A;  3BIP A;  4RZZ A;  3CTZ A;  3S6B A;  3PKC A;  3CB6 A;  4IKT A;  4FLK A;  2Q94 A;  2GG2 A;  2ADU A;  2BB7 A;  1XGN A;  3IG4 A;  1YW9 A;  2BWX A;  2P98 A;  2B3L A;  4FKC A;  4U6W A;  2BHD A;  5CDV A;  2G6P A;  2GG8 A;  2EA4 A;  1C21 A;  1W7V A;  4U6C A;  2GA2 A;  2NQ6 A;  1C23 A;  1CHM A;  3RVA A;  1WLR A;  3PKB A;  2Q8K A;  2B3K A;  1QXZ A;  2V3X A;  1WL6 A;  1B6A A;  2Q92 A;  2DFI A;  4IU6 A;  4QR8 A;  3PKD A;  1WN1 A;  3Q6D A;  1A16 A;  1R58 A;  1WBQ A;  1KP0 A;  4ZWO A;  3D27 A;  3TB5 A;  4S00 A;  1C24 A;  2BWV A;  2GU6 A;  4S01 A;  1B59 A;  4IKS A;  2B3H A;  4ZWU A;  2Q93 A;  1C22 A;  4IEC A;  4U6Z A;  5CIK A;  2P9A A;  2EVC A;  2GU5 A;  4RGZ 1;  3IU9 A;  2V3Y A;  4MAT A;  5CLS A;  5CDE A;  1YVM A;  2BWW A;  4FO7 A;  4FUK A;  2MAT A;  2BWT A;  2GU4 A;  1MAT A;  1KQ0 A;  2EVM A;  2GZ5 A;  2Q96 A;  4PNC A;  3MR1 A;  5FCF A;  1KQ9 A;  5CNX A;  2EVO A;  2BWY A; 
#chains in the Genus database with same CATH homology
 1YW7 A;  4IPA A;  1QXW A;  4U70 A;  1N51 A;  3FMR A;  5E5B A;  4RZY A;  3TAV A;  1WY2 A;  3L24 A;  1O0X A;  4S2R P;  4U71 A;  4IKR A;  5JHU A;  2GU7 A;  1JAW A;  1WL9 A;  2GG7 A;  4IDY A;  1BOA A;  5CE6 A;  1PV9 A;  5JI6 A;  2BH3 A;  2BWS A;  4IF7 A;  1YJ3 A;  4KM3 A;  3IU8 A;  2HOW A;  2IW2 A;  1QXY A;  4R60 A;  2OAZ A;  4U6J A;  2GG0 A;  2ZSG A;  4U76 A;  5D6F A;  1XGO A;  2GG9 A;  2GGB A;  4EGE A;  2BN7 A;  1BN5 A;  2BWU A;  2GTX A;  5FCH A;  5D6E A;  4JUQ A;  2GG5 A;  3CB5 A;  1XGS A;  1WKM A;  1R5H A;  1XNZ A;  3ROR A;  2EA2 A;  1W2M A;  1R5G A;  2GG3 A;  4PV4 A;  3L7G A;  2BHB A;  2P99 A;  4U73 A;  2NQ7 A;  4FO8 A;  3BIQ A;  4IKU A;  1Y1N A;  2V6C A;  4U6E A;  1M35 A;  4U1B A;  3IU7 A;  2GGC A;  3MAT A;  4U69 A;  4S2T P;  4FLI A;  4FLJ A;  4U75 A;  4A6W A;  5CDL A;  2BHC A;  3MX6 A;  4Z7M A;  4B28 A;  2BHA A;  4OOK A;  4ZNG A;  2V3Z A;  3FM3 A;  3PKE A;  3BIT A;  4A6V A;  1QZY A;  1XGM A;  1YW8 A;  3PKA A;  4FLL A;  5JFR A;  4ZWP A;  3FMQ A;  2OKN A;  4HXX A;  1C27 A;  2Q95 A;  3BIP A;  4RZZ A;  3CTZ A;  3S6B A;  3PKC A;  3CB6 A;  4IKT A;  4FLK A;  2Q94 A;  2GG2 A;  2ADU A;  2BB7 A;  1XGN A;  3IG4 A;  1YW9 A;  2BWX A;  2P98 A;  2B3L A;  4FKC A;  4U6W A;  2BHD A;  5CDV A;  2G6P A;  2GG8 A;  2EA4 A;  1C21 A;  1W7V A;  4U6C A;  2GA2 A;  2NQ6 A;  1C23 A;  1CHM A;  3RVA A;  1WLR A;  3PKB A;  2Q8K A;  2B3K A;  1QXZ A;  2V3X A;  1WL6 A;  1B6A A;  2Q92 A;  2DFI A;  4IU6 A;  4QR8 A;  3PKD A;  1WN1 A;  3Q6D A;  1A16 A;  1R58 A;  1WBQ A;  1KP0 A;  4ZWO A;  3D27 A;  3TB5 A;  4S00 A;  1C24 A;  2BWV A;  2GU6 A;  4S01 A;  1B59 A;  4IKS A;  2B3H A;  4ZWU A;  2Q93 A;  1C22 A;  4IEC A;  4U6Z A;  5CIK A;  2P9A A;  2EVC A;  2GU5 A;  4RGZ 1;  3IU9 A;  2V3Y A;  4MAT A;  5CLS A;  5CDE A;  1YVM A;  2BWW A;  4FO7 A;  4FUK A;  2MAT A;  2BWT A;  2GU4 A;  1MAT A;  1KQ0 A;  2EVM A;  2GZ5 A;  2Q96 A;  4PNC A;  3MR1 A;  5FCF A;  1KQ9 A;  5CNX A;  2EVO A;  2BWY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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