4A6WA

X-ray structures of oxazole hydroxamate ecmetap-mn complexes
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule keywords METHIONINE AMINOPEPTIDASE
publication title Hydroxamic Acids as Potent Inhibitors of Fe(II) and Mn(II) E. Coli Methionine Aminopeptidase: Biological Activities and X-Ray Structures of Oxazole Hydroxamate-Ecmetap-Mn Complexes.
pubmed doi rcsb
molecule tags Transferase
total genus 83
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2011-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4a6wA00
1YVMA 4U76A 2GG9A 4FLKA 3S6BA 4IPAA 4U73A 4ZWPA 1R5HA 4U75A 2Q95A 1YW7A 1QXWA 4FO8A 4U1BA 4EGEA 5CE6A 4QR8A 1M35A 2BHDA 5FCFA 1PV9A 4A6WA 1BN5A 4S00A 1Y1NA 1KQ0A 4RZYA 2BB7A 2EA4A 2BH3A 2EVCA 1WLRA 4S01A 5CIKA 3IU8A 4FO7A 4U69A 3TAVA 3Q6DA 1C24A 2BWVA 3BIPA 5CDLA 1R58A 2EVOA 1BOAA 2EVMA 5CLSA 2V3ZA 3IG4A 4U70A 2V3XA 4FKCA 4IU6A 4B28A 1WN1A 4KM3A 1XGNA 4U6WA 2BWXA 2NQ6A 1A16A 4HXXA 4ZWUA 4U6CA 1C27A 2P98A 4ZWOA 2BHAA 2V6CA 1O0XA 4FLJA 2BN7A 5JHUA 1YW9A 1C23A 3PKAA 2GGCA 3BITA 4RZZA 1WKMA 3IU7A 4IKRA 5E5BA 4S2RP 2GU7A 5JFRA 1XGOA 2B3KA 1KP0A 1JAWA 2GG3A 3BIQA 3FMRA 3MR1A 4FLIA 4IKSA 4U6JA 2GG0A 2GG2A 2DFIA 1W7VA 2BWSA 2GG5A 2HOWA 2Q93A 2ZSGA 2V3YA 3PKEA 2Q92A 5CDVA 3FM3A 2GU4A 1QXZA 1YW8A 2G6PA 3CTZA 1QZYA 2BHCA 2GA2A 4FLLA 4U71A 3CB5A 2GU6A 1XGSA 2NQ7A 1XGMA 1W2MA 4IKTA 2GZ5A 2Q96A 1XNZA 3MX6A 3PKDA 3L24A 3PKBA 2Q8KA 3TB5A 1QXYA 3MATA 2OAZA 4OOKA 4MATA 1KQ9A 2BWTA 4R60A 2GTXA 3L7GA 2BHBA 5CDEA 1WY2A 1WL6A 1B59A 1WBQA 1C21A 5D6FA 1WL9A 5FCHA 4U6ZA 4JUQA 2ADUA 1C22A 2Q94A 3RORA 4IECA 4Z7MA 2EA2A 4PNCA 3CB6A 2B3LA 1YJ3A 1CHMA 1N51A 2GG8A 2BWUA 1B6AA 2P9AA 2B3HA 3RVAA 2BWWA 4ZNGA 4IKUA 4U6EA 2GG7A 2BWYA 4RGZ1 2OKNA 4PV4A 3FMQA 1R5GA 4IF7A 5CNXA 3D27A 4S2TP 5D6EA 5JI6A 4IDYA 2P99A 2MATA 1MATA 4FUKA 2GGBA 4A6VA 2GU5A 2IW2A 3PKCA 3IU9A
chains in the Genus database with same CATH superfamily
1YVMA 4U76A 2GG9A 4FLKA 3S6BA 4IPAA 4U73A 4ZWPA 1R5HA 4U75A 2Q95A 1YW7A 1QXWA 4FO8A 4U1BA 4EGEA 5CE6A 4QR8A 1M35A 2BHDA 5FCFA 1PV9A 4A6WA 1BN5A 4S00A 1Y1NA 1KQ0A 4RZYA 2BB7A 2EA4A 2BH3A 2EVCA 1WLRA 4S01A 5CIKA 3IU8A 4FO7A 4U69A 3TAVA 3Q6DA 1C24A 2BWVA 3BIPA 5CDLA 1R58A 2EVOA 1BOAA 2EVMA 5CLSA 2V3ZA 3IG4A 4U70A 2V3XA 4FKCA 4IU6A 4B28A 1WN1A 4KM3A 1XGNA 4U6WA 2BWXA 2NQ6A 1A16A 4HXXA 4ZWUA 4U6CA 1C27A 2P98A 4ZWOA 2BHAA 2V6CA 1O0XA 4FLJA 2BN7A 5JHUA 1YW9A 1C23A 3PKAA 2GGCA 3BITA 4RZZA 1WKMA 3IU7A 4IKRA 5E5BA 4S2RP 2GU7A 5JFRA 1XGOA 2B3KA 1KP0A 1JAWA 2GG3A 3BIQA 3FMRA 3MR1A 4FLIA 4IKSA 4U6JA 2GG0A 2GG2A 2DFIA 1W7VA 2BWSA 2GG5A 2HOWA 2Q93A 2ZSGA 2V3YA 3PKEA 2Q92A 5CDVA 3FM3A 2GU4A 1QXZA 1YW8A 2G6PA 3CTZA 1QZYA 2BHCA 2GA2A 4FLLA 4U71A 3CB5A 2GU6A 1XGSA 2NQ7A 1XGMA 1W2MA 4IKTA 2GZ5A 2Q96A 1XNZA 3MX6A 3PKDA 3L24A 3PKBA 2Q8KA 3TB5A 1QXYA 3MATA 2OAZA 4OOKA 4MATA 1KQ9A 2BWTA 4R60A 2GTXA 3L7GA 2BHBA 5CDEA 1WY2A 1WL6A 1B59A 1WBQA 1C21A 5D6FA 1WL9A 5FCHA 4U6ZA 4JUQA 2ADUA 1C22A 2Q94A 3RORA 4IECA 4Z7MA 2EA2A 4PNCA 3CB6A 2B3LA 1YJ3A 1CHMA 1N51A 2GG8A 2BWUA 1B6AA 2P9AA 2B3HA 3RVAA 2BWWA 4ZNGA 4IKUA 4U6EA 2GG7A 2BWYA 4RGZ1 2OKNA 4PV4A 3FMQA 1R5GA 4IF7A 5CNXA 3D27A 4S2TP 5D6EA 5JI6A 4IDYA 2P99A 2MATA 1MATA 4FUKA 2GGBA 4A6VA 2GU5A 2IW2A 3PKCA 3IU9A
chains in the Genus database with same CATH topology
1YVMA 4U76A 2GG9A 4FLKA 3S6BA 4IPAA 4U73A 4ZWPA 1R5HA 4U75A 2Q95A 1YW7A 1QXWA 4FO8A 4U1BA 4EGEA 5CE6A 4QR8A 1M35A 2BHDA 5FCFA 1PV9A 4A6WA 1BN5A 4S00A 1Y1NA 1KQ0A 4RZYA 2BB7A 2EA4A 2BH3A 2EVCA 1WLRA 4S01A 5CIKA 3IU8A 4FO7A 4U69A 3TAVA 3Q6DA 1C24A 2BWVA 3BIPA 5CDLA 1R58A 2EVOA 1BOAA 2EVMA 5CLSA 2V3ZA 3IG4A 4U70A 2V3XA 4FKCA 4IU6A 4B28A 1WN1A 4KM3A 1XGNA 4U6WA 2BWXA 2NQ6A 1A16A 4HXXA 4ZWUA 4U6CA 1C27A 2P98A 4ZWOA 2BHAA 2V6CA 1O0XA 4FLJA 2BN7A 5JHUA 1YW9A 1C23A 3PKAA 2GGCA 3BITA 4RZZA 1WKMA 3IU7A 4IKRA 5E5BA 4S2RP 2GU7A 5JFRA 1XGOA 2B3KA 1KP0A 1JAWA 2GG3A 3BIQA 3FMRA 3MR1A 4FLIA 4IKSA 4U6JA 2GG0A 2GG2A 2DFIA 1W7VA 2BWSA 2GG5A 2HOWA 2Q93A 2ZSGA 2V3YA 3PKEA 2Q92A 5CDVA 3FM3A 2GU4A 1QXZA 1YW8A 2G6PA 3CTZA 1QZYA 2BHCA 2GA2A 4FLLA 4U71A 3CB5A 2GU6A 1XGSA 2NQ7A 1XGMA 1W2MA 4IKTA 2GZ5A 2Q96A 1XNZA 3MX6A 3PKDA 3L24A 3PKBA 2Q8KA 3TB5A 1QXYA 3MATA 2OAZA 4OOKA 4MATA 1KQ9A 2BWTA 4R60A 2GTXA 3L7GA 2BHBA 5CDEA 1WY2A 1WL6A 1B59A 1WBQA 1C21A 5D6FA 1WL9A 5FCHA 4U6ZA 4JUQA 2ADUA 1C22A 2Q94A 3RORA 4IECA 4Z7MA 2EA2A 4PNCA 3CB6A 2B3LA 1YJ3A 1CHMA 1N51A 2GG8A 2BWUA 1B6AA 2P9AA 2B3HA 3RVAA 2BWWA 4ZNGA 4IKUA 4U6EA 2GG7A 2BWYA 4RGZ1 2OKNA 4PV4A 3FMQA 1R5GA 4IF7A 5CNXA 3D27A 4S2TP 5D6EA 5JI6A 4IDYA 2P99A 2MATA 1MATA 4FUKA 2GGBA 4A6VA 2GU5A 2IW2A 3PKCA 3IU9A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1YVM A;  4U76 A;  2GG9 A;  4FLK A;  3S6B A;  4IPA A;  4U73 A;  4ZWP A;  1R5H A;  4U75 A;  2Q95 A;  1YW7 A;  1QXW A;  4FO8 A;  4U1B A;  4EGE A;  5CE6 A;  4QR8 A;  1M35 A;  2BHD A;  5FCF A;  1PV9 A;  4A6W A;  1BN5 A;  4S00 A;  1Y1N A;  1KQ0 A;  4RZY A;  2BB7 A;  2EA4 A;  2BH3 A;  2EVC A;  1WLR A;  4S01 A;  5CIK A;  3IU8 A;  4FO7 A;  4U69 A;  3TAV A;  3Q6D A;  1C24 A;  2BWV A;  3BIP A;  5CDL A;  1R58 A;  2EVO A;  1BOA A;  2EVM A;  5CLS A;  2V3Z A;  3IG4 A;  4U70 A;  2V3X A;  4FKC A;  4IU6 A;  4B28 A;  1WN1 A;  4KM3 A;  1XGN A;  4U6W A;  2BWX A;  2NQ6 A;  1A16 A;  4HXX A;  4ZWU A;  4U6C A;  1C27 A;  2P98 A;  4ZWO A;  2BHA A;  2V6C A;  1O0X A;  4FLJ A;  2BN7 A;  5JHU A;  1YW9 A;  1C23 A;  3PKA A;  2GGC A;  3BIT A;  4RZZ A;  1WKM A;  3IU7 A;  4IKR A;  5E5B A;  4S2R P;  2GU7 A;  5JFR A;  1XGO A;  2B3K A;  1KP0 A;  1JAW A;  2GG3 A;  3BIQ A;  3FMR A;  3MR1 A;  4FLI A;  4IKS A;  4U6J A;  2GG0 A;  2GG2 A;  2DFI A;  1W7V A;  2BWS A;  2GG5 A;  2HOW A;  2Q93 A;  2ZSG A;  2V3Y A;  3PKE A;  2Q92 A;  5CDV A;  3FM3 A;  2GU4 A;  1QXZ A;  1YW8 A;  2G6P A;  3CTZ A;  1QZY A;  2BHC A;  2GA2 A;  4FLL A;  4U71 A;  3CB5 A;  2GU6 A;  1XGS A;  2NQ7 A;  1XGM A;  1W2M A;  4IKT A;  2GZ5 A;  2Q96 A;  1XNZ A;  3MX6 A;  3PKD A;  3L24 A;  3PKB A;  2Q8K A;  3TB5 A;  1QXY A;  3MAT A;  2OAZ A;  4OOK A;  4MAT A;  1KQ9 A;  2BWT A;  4R60 A;  2GTX A;  3L7G A;  2BHB A;  5CDE A;  1WY2 A;  1WL6 A;  1B59 A;  1WBQ A;  1C21 A;  5D6F A;  1WL9 A;  5FCH A;  4U6Z A;  4JUQ A;  2ADU A;  1C22 A;  2Q94 A;  3ROR A;  4IEC A;  4Z7M A;  2EA2 A;  4PNC A;  3CB6 A;  2B3L A;  1YJ3 A;  1CHM A;  1N51 A;  2GG8 A;  2BWU A;  1B6A A;  2P9A A;  2B3H A;  3RVA A;  2BWW A;  4ZNG A;  4IKU A;  4U6E A;  2GG7 A;  2BWY A;  4RGZ 1;  2OKN A;  4PV4 A;  3FMQ A;  1R5G A;  4IF7 A;  5CNX A;  3D27 A;  4S2T P;  5D6E A;  5JI6 A;  4IDY A;  2P99 A;  2MAT A;  1MAT A;  4FUK A;  2GGB A;  4A6V A;  2GU5 A;  2IW2 A;  3PKC A;  3IU9 A; 
#chains in the Genus database with same CATH topology
 1YVM A;  4U76 A;  2GG9 A;  4FLK A;  3S6B A;  4IPA A;  4U73 A;  4ZWP A;  1R5H A;  4U75 A;  2Q95 A;  1YW7 A;  1QXW A;  4FO8 A;  4U1B A;  4EGE A;  5CE6 A;  4QR8 A;  1M35 A;  2BHD A;  5FCF A;  1PV9 A;  4A6W A;  1BN5 A;  4S00 A;  1Y1N A;  1KQ0 A;  4RZY A;  2BB7 A;  2EA4 A;  2BH3 A;  2EVC A;  1WLR A;  4S01 A;  5CIK A;  3IU8 A;  4FO7 A;  4U69 A;  3TAV A;  3Q6D A;  1C24 A;  2BWV A;  3BIP A;  5CDL A;  1R58 A;  2EVO A;  1BOA A;  2EVM A;  5CLS A;  2V3Z A;  3IG4 A;  4U70 A;  2V3X A;  4FKC A;  4IU6 A;  4B28 A;  1WN1 A;  4KM3 A;  1XGN A;  4U6W A;  2BWX A;  2NQ6 A;  1A16 A;  4HXX A;  4ZWU A;  4U6C A;  1C27 A;  2P98 A;  4ZWO A;  2BHA A;  2V6C A;  1O0X A;  4FLJ A;  2BN7 A;  5JHU A;  1YW9 A;  1C23 A;  3PKA A;  2GGC A;  3BIT A;  4RZZ A;  1WKM A;  3IU7 A;  4IKR A;  5E5B A;  4S2R P;  2GU7 A;  5JFR A;  1XGO A;  2B3K A;  1KP0 A;  1JAW A;  2GG3 A;  3BIQ A;  3FMR A;  3MR1 A;  4FLI A;  4IKS A;  4U6J A;  2GG0 A;  2GG2 A;  2DFI A;  1W7V A;  2BWS A;  2GG5 A;  2HOW A;  2Q93 A;  2ZSG A;  2V3Y A;  3PKE A;  2Q92 A;  5CDV A;  3FM3 A;  2GU4 A;  1QXZ A;  1YW8 A;  2G6P A;  3CTZ A;  1QZY A;  2BHC A;  2GA2 A;  4FLL A;  4U71 A;  3CB5 A;  2GU6 A;  1XGS A;  2NQ7 A;  1XGM A;  1W2M A;  4IKT A;  2GZ5 A;  2Q96 A;  1XNZ A;  3MX6 A;  3PKD A;  3L24 A;  3PKB A;  2Q8K A;  3TB5 A;  1QXY A;  3MAT A;  2OAZ A;  4OOK A;  4MAT A;  1KQ9 A;  2BWT A;  4R60 A;  2GTX A;  3L7G A;  2BHB A;  5CDE A;  1WY2 A;  1WL6 A;  1B59 A;  1WBQ A;  1C21 A;  5D6F A;  1WL9 A;  5FCH A;  4U6Z A;  4JUQ A;  2ADU A;  1C22 A;  2Q94 A;  3ROR A;  4IEC A;  4Z7M A;  2EA2 A;  4PNC A;  3CB6 A;  2B3L A;  1YJ3 A;  1CHM A;  1N51 A;  2GG8 A;  2BWU A;  1B6A A;  2P9A A;  2B3H A;  3RVA A;  2BWW A;  4ZNG A;  4IKU A;  4U6E A;  2GG7 A;  2BWY A;  4RGZ 1;  2OKN A;  4PV4 A;  3FMQ A;  1R5G A;  4IF7 A;  5CNX A;  3D27 A;  4S2T P;  5D6E A;  5JI6 A;  4IDY A;  2P99 A;  2MAT A;  1MAT A;  4FUK A;  2GGB A;  4A6V A;  2GU5 A;  2IW2 A;  3PKC A;  3IU9 A; 
#chains in the Genus database with same CATH homology
 1YVM A;  4U76 A;  2GG9 A;  4FLK A;  3S6B A;  4IPA A;  4U73 A;  4ZWP A;  1R5H A;  4U75 A;  2Q95 A;  1YW7 A;  1QXW A;  4FO8 A;  4U1B A;  4EGE A;  5CE6 A;  4QR8 A;  1M35 A;  2BHD A;  5FCF A;  1PV9 A;  4A6W A;  1BN5 A;  4S00 A;  1Y1N A;  1KQ0 A;  4RZY A;  2BB7 A;  2EA4 A;  2BH3 A;  2EVC A;  1WLR A;  4S01 A;  5CIK A;  3IU8 A;  4FO7 A;  4U69 A;  3TAV A;  3Q6D A;  1C24 A;  2BWV A;  3BIP A;  5CDL A;  1R58 A;  2EVO A;  1BOA A;  2EVM A;  5CLS A;  2V3Z A;  3IG4 A;  4U70 A;  2V3X A;  4FKC A;  4IU6 A;  4B28 A;  1WN1 A;  4KM3 A;  1XGN A;  4U6W A;  2BWX A;  2NQ6 A;  1A16 A;  4HXX A;  4ZWU A;  4U6C A;  1C27 A;  2P98 A;  4ZWO A;  2BHA A;  2V6C A;  1O0X A;  4FLJ A;  2BN7 A;  5JHU A;  1YW9 A;  1C23 A;  3PKA A;  2GGC A;  3BIT A;  4RZZ A;  1WKM A;  3IU7 A;  4IKR A;  5E5B A;  4S2R P;  2GU7 A;  5JFR A;  1XGO A;  2B3K A;  1KP0 A;  1JAW A;  2GG3 A;  3BIQ A;  3FMR A;  3MR1 A;  4FLI A;  4IKS A;  4U6J A;  2GG0 A;  2GG2 A;  2DFI A;  1W7V A;  2BWS A;  2GG5 A;  2HOW A;  2Q93 A;  2ZSG A;  2V3Y A;  3PKE A;  2Q92 A;  5CDV A;  3FM3 A;  2GU4 A;  1QXZ A;  1YW8 A;  2G6P A;  3CTZ A;  1QZY A;  2BHC A;  2GA2 A;  4FLL A;  4U71 A;  3CB5 A;  2GU6 A;  1XGS A;  2NQ7 A;  1XGM A;  1W2M A;  4IKT A;  2GZ5 A;  2Q96 A;  1XNZ A;  3MX6 A;  3PKD A;  3L24 A;  3PKB A;  2Q8K A;  3TB5 A;  1QXY A;  3MAT A;  2OAZ A;  4OOK A;  4MAT A;  1KQ9 A;  2BWT A;  4R60 A;  2GTX A;  3L7G A;  2BHB A;  5CDE A;  1WY2 A;  1WL6 A;  1B59 A;  1WBQ A;  1C21 A;  5D6F A;  1WL9 A;  5FCH A;  4U6Z A;  4JUQ A;  2ADU A;  1C22 A;  2Q94 A;  3ROR A;  4IEC A;  4Z7M A;  2EA2 A;  4PNC A;  3CB6 A;  2B3L A;  1YJ3 A;  1CHM A;  1N51 A;  2GG8 A;  2BWU A;  1B6A A;  2P9A A;  2B3H A;  3RVA A;  2BWW A;  4ZNG A;  4IKU A;  4U6E A;  2GG7 A;  2BWY A;  4RGZ 1;  2OKN A;  4PV4 A;  3FMQ A;  1R5G A;  4IF7 A;  5CNX A;  3D27 A;  4S2T P;  5D6E A;  5JI6 A;  4IDY A;  2P99 A;  2MAT A;  1MAT A;  4FUK A;  2GGB A;  4A6V A;  2GU5 A;  2IW2 A;  3PKC A;  3IU9 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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