2GG0A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
262
structure length
262
Chain Sequence
ISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli k12
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 84
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg0A00
1YW8A 2GU5A 5CIKA 1YW9A 2BHBA 3L24A 1W2MA 1C27A 4IKUA 2BH3A 3TAVA 4S2RP 2GU6A 2BHCA 2Q93A 1M35A 4S01A 4MATA 5JHUA 4FKCA 4IPAA 4KM3A 2MATA 1R58A 4IKRA 4FO8A 2GG2A 1CHMA 1C23A 5CE6A 2OKNA 2P99A 3FMRA 4S00A 4U1BA 1QXZA 3RORA 1XNZA 2BHDA 1MATA 1YJ3A 5D6FA 2BWVA 2BWWA 3PKEA 4RZYA 2BHAA 2GGCA 1KQ0A 3CTZA 2EVCA 4Z7MA 1WN1A 2B3KA 2ZSGA 4PV4A 1WL6A 4FO7A 1WBQA 5FCFA 1YW7A 1XGSA 1WL9A 2GG5A 2P9AA 4IU6A 3CB6A 4U6CA 3RVAA 2Q96A 1C22A 2NQ6A 1JAWA 3PKBA 2OAZA 4U6EA 4RZZA 4ZWUA 1YVMA 5E5BA 5CDLA 4PNCA 3BITA 2EVOA 4A6WA 5JI6A 3MR1A 4U6WA 4IF7A 3D27A 5CDEA 3PKCA 2B3LA 1KP0A 2GG0A 1N51A 3BIQA 2V3ZA 4ZWOA 2Q94A 1WLRA 2HOWA 2P98A 4IKSA 2B3HA 3Q6DA 4R60A 5CNXA 4FLLA 4FLJA 1WY2A 1WKMA 3FM3A 3IU8A 4A6VA 2GG7A 4OOKA 4ZNGA 1QXWA 4HXXA 2GG8A 2NQ7A 4S2TP 1QZYA 1PV9A 1W7VA 2G6PA 2GU4A 3CB5A 4FLIA 3TB5A 2DFIA 3BIPA 4U71A 4U73A 1C24A 1BN5A 1XGMA 1XGOA 2EVMA 4U75A 2EA2A 4FLKA 2Q8KA 2GA2A 2Q92A 4EGEA 1C21A 2BB7A 3IG4A 3IU9A 3MATA 5CDVA 4U6ZA 2GU7A 1O0XA 1B6AA 2GG9A 2V6CA 1R5GA 2ADUA 2BWUA 4IDYA 4B28A 4U70A 1Y1NA 2GG3A 5CLSA 2BWSA 4U69A 4ZWPA 1XGNA 5JFRA 4U6JA 1KQ9A 1BOAA 2BWTA 2IW2A 4QR8A 2V3YA 3PKAA 2GTXA 3MX6A 3S6BA 1QXYA 1A16A 2EA4A 1B59A 2Q95A 3FMQA 1R5HA 5D6EA 5FCHA 2GGBA 3IU7A 2GZ5A 2BWXA 4IKTA 4JUQA 3L7GA 4RGZ1 2V3XA 4FUKA 4IECA 2BN7A 2BWYA 4U76A 3PKDA
chains in the Genus database with same CATH superfamily
1YW8A 2GU5A 5CIKA 1YW9A 2BHBA 3L24A 1W2MA 1C27A 4IKUA 2BH3A 3TAVA 4S2RP 2GU6A 2BHCA 2Q93A 1M35A 4S01A 4MATA 5JHUA 4FKCA 4IPAA 4KM3A 2MATA 1R58A 4IKRA 4FO8A 2GG2A 1CHMA 1C23A 5CE6A 2OKNA 2P99A 3FMRA 4S00A 4U1BA 1QXZA 3RORA 1XNZA 2BHDA 1MATA 1YJ3A 5D6FA 2BWVA 2BWWA 3PKEA 4RZYA 2BHAA 2GGCA 1KQ0A 3CTZA 2EVCA 4Z7MA 1WN1A 2B3KA 2ZSGA 4PV4A 1WL6A 4FO7A 1WBQA 5FCFA 1YW7A 1XGSA 1WL9A 2GG5A 2P9AA 4IU6A 3CB6A 4U6CA 3RVAA 2Q96A 1C22A 2NQ6A 1JAWA 3PKBA 2OAZA 4U6EA 4RZZA 4ZWUA 1YVMA 5E5BA 5CDLA 4PNCA 3BITA 2EVOA 4A6WA 5JI6A 3MR1A 4U6WA 4IF7A 3D27A 5CDEA 3PKCA 2B3LA 1KP0A 2GG0A 1N51A 3BIQA 2V3ZA 4ZWOA 2Q94A 1WLRA 2HOWA 2P98A 4IKSA 2B3HA 3Q6DA 4R60A 5CNXA 4FLLA 4FLJA 1WY2A 1WKMA 3FM3A 3IU8A 4A6VA 2GG7A 4OOKA 4ZNGA 1QXWA 4HXXA 2GG8A 2NQ7A 4S2TP 1QZYA 1PV9A 1W7VA 2G6PA 2GU4A 3CB5A 4FLIA 3TB5A 2DFIA 3BIPA 4U71A 4U73A 1C24A 1BN5A 1XGMA 1XGOA 2EVMA 4U75A 2EA2A 4FLKA 2Q8KA 2GA2A 2Q92A 4EGEA 1C21A 2BB7A 3IG4A 3IU9A 3MATA 5CDVA 4U6ZA 2GU7A 1O0XA 1B6AA 2GG9A 2V6CA 1R5GA 2ADUA 2BWUA 4IDYA 4B28A 4U70A 1Y1NA 2GG3A 5CLSA 2BWSA 4U69A 4ZWPA 1XGNA 5JFRA 4U6JA 1KQ9A 1BOAA 2BWTA 2IW2A 4QR8A 2V3YA 3PKAA 2GTXA 3MX6A 3S6BA 1QXYA 1A16A 2EA4A 1B59A 2Q95A 3FMQA 1R5HA 5D6EA 5FCHA 2GGBA 3IU7A 2GZ5A 2BWXA 4IKTA 4JUQA 3L7GA 4RGZ1 2V3XA 4FUKA 4IECA 2BN7A 2BWYA 4U76A 3PKDA
chains in the Genus database with same CATH topology
1YW8A 2GU5A 5CIKA 1YW9A 2BHBA 3L24A 1W2MA 1C27A 4IKUA 2BH3A 3TAVA 4S2RP 2GU6A 2BHCA 2Q93A 1M35A 4S01A 4MATA 5JHUA 4FKCA 4IPAA 4KM3A 2MATA 1R58A 4IKRA 4FO8A 2GG2A 1CHMA 1C23A 5CE6A 2OKNA 2P99A 3FMRA 4S00A 4U1BA 1QXZA 3RORA 1XNZA 2BHDA 1MATA 1YJ3A 5D6FA 2BWVA 2BWWA 3PKEA 4RZYA 2BHAA 2GGCA 1KQ0A 3CTZA 2EVCA 4Z7MA 1WN1A 2B3KA 2ZSGA 4PV4A 1WL6A 4FO7A 1WBQA 5FCFA 1YW7A 1XGSA 1WL9A 2GG5A 2P9AA 4IU6A 3CB6A 4U6CA 3RVAA 2Q96A 1C22A 2NQ6A 1JAWA 3PKBA 2OAZA 4U6EA 4RZZA 4ZWUA 1YVMA 5E5BA 5CDLA 4PNCA 3BITA 2EVOA 4A6WA 5JI6A 3MR1A 4U6WA 4IF7A 3D27A 5CDEA 3PKCA 2B3LA 1KP0A 2GG0A 1N51A 3BIQA 2V3ZA 4ZWOA 2Q94A 1WLRA 2HOWA 2P98A 4IKSA 2B3HA 3Q6DA 4R60A 5CNXA 4FLLA 4FLJA 1WY2A 1WKMA 3FM3A 3IU8A 4A6VA 2GG7A 4OOKA 4ZNGA 1QXWA 4HXXA 2GG8A 2NQ7A 4S2TP 1QZYA 1PV9A 1W7VA 2G6PA 2GU4A 3CB5A 4FLIA 3TB5A 2DFIA 3BIPA 4U71A 4U73A 1C24A 1BN5A 1XGMA 1XGOA 2EVMA 4U75A 2EA2A 4FLKA 2Q8KA 2GA2A 2Q92A 4EGEA 1C21A 2BB7A 3IG4A 3IU9A 3MATA 5CDVA 4U6ZA 2GU7A 1O0XA 1B6AA 2GG9A 2V6CA 1R5GA 2ADUA 2BWUA 4IDYA 4B28A 4U70A 1Y1NA 2GG3A 5CLSA 2BWSA 4U69A 4ZWPA 1XGNA 5JFRA 4U6JA 1KQ9A 1BOAA 2BWTA 2IW2A 4QR8A 2V3YA 3PKAA 2GTXA 3MX6A 3S6BA 1QXYA 1A16A 2EA4A 1B59A 2Q95A 3FMQA 1R5HA 5D6EA 5FCHA 2GGBA 3IU7A 2GZ5A 2BWXA 4IKTA 4JUQA 3L7GA 4RGZ1 2V3XA 4FUKA 4IECA 2BN7A 2BWYA 4U76A 3PKDA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1YW8 A;  2GU5 A;  5CIK A;  1YW9 A;  2BHB A;  3L24 A;  1W2M A;  1C27 A;  4IKU A;  2BH3 A;  3TAV A;  4S2R P;  2GU6 A;  2BHC A;  2Q93 A;  1M35 A;  4S01 A;  4MAT A;  5JHU A;  4FKC A;  4IPA A;  4KM3 A;  2MAT A;  1R58 A;  4IKR A;  4FO8 A;  2GG2 A;  1CHM A;  1C23 A;  5CE6 A;  2OKN A;  2P99 A;  3FMR A;  4S00 A;  4U1B A;  1QXZ A;  3ROR A;  1XNZ A;  2BHD A;  1MAT A;  1YJ3 A;  5D6F A;  2BWV A;  2BWW A;  3PKE A;  4RZY A;  2BHA A;  2GGC A;  1KQ0 A;  3CTZ A;  2EVC A;  4Z7M A;  1WN1 A;  2B3K A;  2ZSG A;  4PV4 A;  1WL6 A;  4FO7 A;  1WBQ A;  5FCF A;  1YW7 A;  1XGS A;  1WL9 A;  2GG5 A;  2P9A A;  4IU6 A;  3CB6 A;  4U6C A;  3RVA A;  2Q96 A;  1C22 A;  2NQ6 A;  1JAW A;  3PKB A;  2OAZ A;  4U6E A;  4RZZ A;  4ZWU A;  1YVM A;  5E5B A;  5CDL A;  4PNC A;  3BIT A;  2EVO A;  4A6W A;  5JI6 A;  3MR1 A;  4U6W A;  4IF7 A;  3D27 A;  5CDE A;  3PKC A;  2B3L A;  1KP0 A;  2GG0 A;  1N51 A;  3BIQ A;  2V3Z A;  4ZWO A;  2Q94 A;  1WLR A;  2HOW A;  2P98 A;  4IKS A;  2B3H A;  3Q6D A;  4R60 A;  5CNX A;  4FLL A;  4FLJ A;  1WY2 A;  1WKM A;  3FM3 A;  3IU8 A;  4A6V A;  2GG7 A;  4OOK A;  4ZNG A;  1QXW A;  4HXX A;  2GG8 A;  2NQ7 A;  4S2T P;  1QZY A;  1PV9 A;  1W7V A;  2G6P A;  2GU4 A;  3CB5 A;  4FLI A;  3TB5 A;  2DFI A;  3BIP A;  4U71 A;  4U73 A;  1C24 A;  1BN5 A;  1XGM A;  1XGO A;  2EVM A;  4U75 A;  2EA2 A;  4FLK A;  2Q8K A;  2GA2 A;  2Q92 A;  4EGE A;  1C21 A;  2BB7 A;  3IG4 A;  3IU9 A;  3MAT A;  5CDV A;  4U6Z A;  2GU7 A;  1O0X A;  1B6A A;  2GG9 A;  2V6C A;  1R5G A;  2ADU A;  2BWU A;  4IDY A;  4B28 A;  4U70 A;  1Y1N A;  2GG3 A;  5CLS A;  2BWS A;  4U69 A;  4ZWP A;  1XGN A;  5JFR A;  4U6J A;  1KQ9 A;  1BOA A;  2BWT A;  2IW2 A;  4QR8 A;  2V3Y A;  3PKA A;  2GTX A;  3MX6 A;  3S6B A;  1QXY A;  1A16 A;  2EA4 A;  1B59 A;  2Q95 A;  3FMQ A;  1R5H A;  5D6E A;  5FCH A;  2GGB A;  3IU7 A;  2GZ5 A;  2BWX A;  4IKT A;  4JUQ A;  3L7G A;  4RGZ 1;  2V3X A;  4FUK A;  4IEC A;  2BN7 A;  2BWY A;  4U76 A;  3PKD A; 
#chains in the Genus database with same CATH topology
 1YW8 A;  2GU5 A;  5CIK A;  1YW9 A;  2BHB A;  3L24 A;  1W2M A;  1C27 A;  4IKU A;  2BH3 A;  3TAV A;  4S2R P;  2GU6 A;  2BHC A;  2Q93 A;  1M35 A;  4S01 A;  4MAT A;  5JHU A;  4FKC A;  4IPA A;  4KM3 A;  2MAT A;  1R58 A;  4IKR A;  4FO8 A;  2GG2 A;  1CHM A;  1C23 A;  5CE6 A;  2OKN A;  2P99 A;  3FMR A;  4S00 A;  4U1B A;  1QXZ A;  3ROR A;  1XNZ A;  2BHD A;  1MAT A;  1YJ3 A;  5D6F A;  2BWV A;  2BWW A;  3PKE A;  4RZY A;  2BHA A;  2GGC A;  1KQ0 A;  3CTZ A;  2EVC A;  4Z7M A;  1WN1 A;  2B3K A;  2ZSG A;  4PV4 A;  1WL6 A;  4FO7 A;  1WBQ A;  5FCF A;  1YW7 A;  1XGS A;  1WL9 A;  2GG5 A;  2P9A A;  4IU6 A;  3CB6 A;  4U6C A;  3RVA A;  2Q96 A;  1C22 A;  2NQ6 A;  1JAW A;  3PKB A;  2OAZ A;  4U6E A;  4RZZ A;  4ZWU A;  1YVM A;  5E5B A;  5CDL A;  4PNC A;  3BIT A;  2EVO A;  4A6W A;  5JI6 A;  3MR1 A;  4U6W A;  4IF7 A;  3D27 A;  5CDE A;  3PKC A;  2B3L A;  1KP0 A;  2GG0 A;  1N51 A;  3BIQ A;  2V3Z A;  4ZWO A;  2Q94 A;  1WLR A;  2HOW A;  2P98 A;  4IKS A;  2B3H A;  3Q6D A;  4R60 A;  5CNX A;  4FLL A;  4FLJ A;  1WY2 A;  1WKM A;  3FM3 A;  3IU8 A;  4A6V A;  2GG7 A;  4OOK A;  4ZNG A;  1QXW A;  4HXX A;  2GG8 A;  2NQ7 A;  4S2T P;  1QZY A;  1PV9 A;  1W7V A;  2G6P A;  2GU4 A;  3CB5 A;  4FLI A;  3TB5 A;  2DFI A;  3BIP A;  4U71 A;  4U73 A;  1C24 A;  1BN5 A;  1XGM A;  1XGO A;  2EVM A;  4U75 A;  2EA2 A;  4FLK A;  2Q8K A;  2GA2 A;  2Q92 A;  4EGE A;  1C21 A;  2BB7 A;  3IG4 A;  3IU9 A;  3MAT A;  5CDV A;  4U6Z A;  2GU7 A;  1O0X A;  1B6A A;  2GG9 A;  2V6C A;  1R5G A;  2ADU A;  2BWU A;  4IDY A;  4B28 A;  4U70 A;  1Y1N A;  2GG3 A;  5CLS A;  2BWS A;  4U69 A;  4ZWP A;  1XGN A;  5JFR A;  4U6J A;  1KQ9 A;  1BOA A;  2BWT A;  2IW2 A;  4QR8 A;  2V3Y A;  3PKA A;  2GTX A;  3MX6 A;  3S6B A;  1QXY A;  1A16 A;  2EA4 A;  1B59 A;  2Q95 A;  3FMQ A;  1R5H A;  5D6E A;  5FCH A;  2GGB A;  3IU7 A;  2GZ5 A;  2BWX A;  4IKT A;  4JUQ A;  3L7G A;  4RGZ 1;  2V3X A;  4FUK A;  4IEC A;  2BN7 A;  2BWY A;  4U76 A;  3PKD A; 
#chains in the Genus database with same CATH homology
 1YW8 A;  2GU5 A;  5CIK A;  1YW9 A;  2BHB A;  3L24 A;  1W2M A;  1C27 A;  4IKU A;  2BH3 A;  3TAV A;  4S2R P;  2GU6 A;  2BHC A;  2Q93 A;  1M35 A;  4S01 A;  4MAT A;  5JHU A;  4FKC A;  4IPA A;  4KM3 A;  2MAT A;  1R58 A;  4IKR A;  4FO8 A;  2GG2 A;  1CHM A;  1C23 A;  5CE6 A;  2OKN A;  2P99 A;  3FMR A;  4S00 A;  4U1B A;  1QXZ A;  3ROR A;  1XNZ A;  2BHD A;  1MAT A;  1YJ3 A;  5D6F A;  2BWV A;  2BWW A;  3PKE A;  4RZY A;  2BHA A;  2GGC A;  1KQ0 A;  3CTZ A;  2EVC A;  4Z7M A;  1WN1 A;  2B3K A;  2ZSG A;  4PV4 A;  1WL6 A;  4FO7 A;  1WBQ A;  5FCF A;  1YW7 A;  1XGS A;  1WL9 A;  2GG5 A;  2P9A A;  4IU6 A;  3CB6 A;  4U6C A;  3RVA A;  2Q96 A;  1C22 A;  2NQ6 A;  1JAW A;  3PKB A;  2OAZ A;  4U6E A;  4RZZ A;  4ZWU A;  1YVM A;  5E5B A;  5CDL A;  4PNC A;  3BIT A;  2EVO A;  4A6W A;  5JI6 A;  3MR1 A;  4U6W A;  4IF7 A;  3D27 A;  5CDE A;  3PKC A;  2B3L A;  1KP0 A;  2GG0 A;  1N51 A;  3BIQ A;  2V3Z A;  4ZWO A;  2Q94 A;  1WLR A;  2HOW A;  2P98 A;  4IKS A;  2B3H A;  3Q6D A;  4R60 A;  5CNX A;  4FLL A;  4FLJ A;  1WY2 A;  1WKM A;  3FM3 A;  3IU8 A;  4A6V A;  2GG7 A;  4OOK A;  4ZNG A;  1QXW A;  4HXX A;  2GG8 A;  2NQ7 A;  4S2T P;  1QZY A;  1PV9 A;  1W7V A;  2G6P A;  2GU4 A;  3CB5 A;  4FLI A;  3TB5 A;  2DFI A;  3BIP A;  4U71 A;  4U73 A;  1C24 A;  1BN5 A;  1XGM A;  1XGO A;  2EVM A;  4U75 A;  2EA2 A;  4FLK A;  2Q8K A;  2GA2 A;  2Q92 A;  4EGE A;  1C21 A;  2BB7 A;  3IG4 A;  3IU9 A;  3MAT A;  5CDV A;  4U6Z A;  2GU7 A;  1O0X A;  1B6A A;  2GG9 A;  2V6C A;  1R5G A;  2ADU A;  2BWU A;  4IDY A;  4B28 A;  4U70 A;  1Y1N A;  2GG3 A;  5CLS A;  2BWS A;  4U69 A;  4ZWP A;  1XGN A;  5JFR A;  4U6J A;  1KQ9 A;  1BOA A;  2BWT A;  2IW2 A;  4QR8 A;  2V3Y A;  3PKA A;  2GTX A;  3MX6 A;  3S6B A;  1QXY A;  1A16 A;  2EA4 A;  1B59 A;  2Q95 A;  3FMQ A;  1R5H A;  5D6E A;  5FCH A;  2GGB A;  3IU7 A;  2GZ5 A;  2BWX A;  4IKT A;  4JUQ A;  3L7G A;  4RGZ 1;  2V3X A;  4FUK A;  4IEC A;  2BN7 A;  2BWY A;  4U76 A;  3PKD A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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