2OKNA

Crystal strcture of human prolidase
Total Genus 160
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
sequence length
477
structure length
477
Chain Sequence
GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystal Structure of Human Prolidase: The Molecular Basis of PD Disease.
rcsb
source organism Homo sapiens
molecule tags Hydrolase
molecule keywords Xaa-Pro dipeptidase
total genus 160
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2007-01-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2oknA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2oknA02
3PN9A 1XGNA 4ZWOA 3PKCA 1WLRA 4ZWUA 2Q96A 2EA2A 2B3HA 1WBQA 1MATA 4FO7A 1WL6A 4S2TP 2BH3A 4MATA 4KM3A 3CB5A 4FO8A 3BIQA 4U76A 1R5GA 2GG2A 2GG9A 2IW2A 1YW9A 4HXXA 5FCHA 3I7MA 3PKBA 1N51A 3OVKA 3PEBA 1Y1NA 5CDEA 4FLIA 3CB6A 5CDLA 2HOWA 2GZ5A 2V3XA 1QXZA 4PV4A 2Q92A 4PNCA 1C22A 4RZYA 5D6EA 4FKCA 2G6PA 4B28A 2GG5A 3BITA 2BWVA 3OOOA 4RZZA 1O0XA 4FLLA 1W2MA 4U6ZA 2Q95A 3BIPA 4U71A 3RORA 3S6BA 2GU4A 2BHBA 1QZYA 5CIKA 1YVMA 4IDYA 1YJ3A 3MR1A 4S01A 2MATA 4Z7MA 2BWTA 2BWXA 4U1BA 2BB7A 2B3LA 4ZWPA 4EGEA 1XNZA 2GG3A 2GU5A 4A6VA 5CLSA 2NQ6A 3IU8A 3MATA 2V3YA 4A6WA 2GGBA 4U6JA 2OKNA 1R58A 1WN1A 1JAWA 2P98A 4U6WA 2GGCA 4IKSA 1KP0A 3D27A 4U6EA 2GA2A 5E5BA 1BN5A 4FUKA 5D6FA 3Q6DA 1XGOA 3PKEA 4IF7A 2EA4A 2Q94A 2BN7A 4IECA 1B59A 3QOCA 5CDVA 4S2RP 1QXYA 5JI6A 2P99A 3FMQA 4QR8A 5CNXA 5JFRA 3IU9A 3L24A 4U73A 4IPAA 2GG8A 1WL9A 1CHMA 1KQ9A 2EVCA 2BHAA 4FLJA 4U6CA 1A16A 4IKUA 4U69A 4IU6A 1YW8A 4S00A 2BWYA 1XGMA 5JHUA 2BHDA 3FMRA 3PKAA 5E2CA 5CE6A 1WY2A 2BWSA 2GG0A 4U75A 2Q8KA 3MX6A 3TB5A 3PKDA 1WKMA 2BHCA 2DFIA 2ZSGA 1YW7A 3IG4A 3TAVA 1B6AA 1R5HA 2Q93A 3IL0A 1W7VA 2GG7A 4RGZ1 1C21A 2BWUA 1C24A 2EVOA 2GU6A 2NQ7A 2OAZA 3FM3A 4JUQA 5FCFA 2EVMA 2P9AA 3L7GA 2BWWA 4ZNGA 2V6CA 4FLKA 4IKRA 4IKTA 4R60A 1C23A 2GU7A 2V3ZA 2B3KA 1KQ0A 3RVAA 1PV9A 1C27A 1QXWA 1XGSA 3IU7A 3CTZA 2GTXA 1BOAA 1M35A 4OOKA 3O5VA 4U70A 2ADUA
chains in the Genus database with same CATH superfamily
3PN9A 1XGNA 4ZWOA 3PKCA 1WLRA 4ZWUA 2Q96A 2EA2A 2B3HA 1WBQA 1MATA 4FO7A 1WL6A 4S2TP 2BH3A 4MATA 4KM3A 3CB5A 4FO8A 3BIQA 4U76A 1R5GA 2GG2A 2GG9A 2IW2A 1YW9A 4HXXA 5FCHA 3I7MA 3PKBA 1N51A 3OVKA 3PEBA 1Y1NA 5CDEA 4FLIA 3CB6A 5CDLA 2HOWA 2GZ5A 2V3XA 1QXZA 4PV4A 2Q92A 4PNCA 1C22A 4RZYA 5D6EA 4FKCA 2G6PA 4B28A 2GG5A 3BITA 2BWVA 3OOOA 4RZZA 1O0XA 4FLLA 1W2MA 4U6ZA 2Q95A 3BIPA 4U71A 3RORA 3S6BA 2GU4A 2BHBA 1QZYA 5CIKA 1YVMA 4IDYA 1YJ3A 3MR1A 4S01A 2MATA 4Z7MA 2BWTA 2BWXA 4U1BA 2BB7A 2B3LA 4ZWPA 4EGEA 1XNZA 2GG3A 2GU5A 4A6VA 5CLSA 2NQ6A 3IU8A 3MATA 2V3YA 4A6WA 2GGBA 4U6JA 2OKNA 1R58A 1WN1A 1JAWA 2P98A 4U6WA 2GGCA 4IKSA 1KP0A 3D27A 4U6EA 2GA2A 5E5BA 1BN5A 4FUKA 5D6FA 3Q6DA 1XGOA 3PKEA 4IF7A 2EA4A 2Q94A 2BN7A 4IECA 1B59A 3QOCA 5CDVA 4S2RP 1QXYA 5JI6A 2P99A 3FMQA 4QR8A 5CNXA 5JFRA 3IU9A 3L24A 4U73A 4IPAA 2GG8A 1WL9A 1CHMA 1KQ9A 2EVCA 2BHAA 4FLJA 4U6CA 1A16A 4IKUA 4U69A 4IU6A 1YW8A 4S00A 2BWYA 1XGMA 5JHUA 2BHDA 3FMRA 3PKAA 5E2CA 5CE6A 1WY2A 2BWSA 2GG0A 4U75A 2Q8KA 3MX6A 3TB5A 3PKDA 1WKMA 2BHCA 2DFIA 2ZSGA 1YW7A 3IG4A 3TAVA 1B6AA 1R5HA 2Q93A 3IL0A 1W7VA 2GG7A 4RGZ1 1C21A 2BWUA 1C24A 2EVOA 2GU6A 2NQ7A 2OAZA 3FM3A 4JUQA 5FCFA 2EVMA 2P9AA 3L7GA 2BWWA 4ZNGA 2V6CA 4FLKA 4IKRA 4IKTA 4R60A 1C23A 2GU7A 2V3ZA 2B3KA 1KQ0A 3RVAA 1PV9A 1C27A 1QXWA 1XGSA 3IU7A 3CTZA 2GTXA 1BOAA 1M35A 4OOKA 3O5VA 4U70A 2ADUA
chains in the Genus database with same CATH topology
3PN9A 1XGNA 4ZWOA 3PKCA 1WLRA 4ZWUA 2Q96A 2EA2A 2B3HA 1WBQA 1MATA 4FO7A 1WL6A 4S2TP 2BH3A 4MATA 4KM3A 3CB5A 4FO8A 3BIQA 4U76A 1R5GA 2GG2A 2GG9A 2IW2A 1YW9A 4HXXA 5FCHA 3I7MA 3PKBA 1N51A 3OVKA 3PEBA 1Y1NA 5CDEA 4FLIA 3CB6A 5CDLA 2HOWA 2GZ5A 2V3XA 1QXZA 4PV4A 2Q92A 4PNCA 1C22A 4RZYA 5D6EA 4FKCA 2G6PA 4B28A 2GG5A 3BITA 2BWVA 3OOOA 4RZZA 1O0XA 4FLLA 1W2MA 4U6ZA 2Q95A 3BIPA 4U71A 3RORA 3S6BA 2GU4A 2BHBA 1QZYA 5CIKA 1YVMA 4IDYA 1YJ3A 3MR1A 4S01A 2MATA 4Z7MA 2BWTA 2BWXA 4U1BA 2BB7A 2B3LA 4ZWPA 4EGEA 1XNZA 2GG3A 2GU5A 4A6VA 5CLSA 2NQ6A 3IU8A 3MATA 2V3YA 4A6WA 2GGBA 4U6JA 2OKNA 1R58A 1WN1A 1JAWA 2P98A 4U6WA 2GGCA 4IKSA 1KP0A 3D27A 4U6EA 2GA2A 5E5BA 1BN5A 4FUKA 5D6FA 3Q6DA 1XGOA 3PKEA 4IF7A 2EA4A 2Q94A 2BN7A 4IECA 1B59A 3QOCA 5CDVA 4S2RP 1QXYA 5JI6A 2P99A 3FMQA 4QR8A 5CNXA 5JFRA 3IU9A 3L24A 4U73A 4IPAA 2GG8A 1WL9A 1CHMA 1KQ9A 2EVCA 2BHAA 4FLJA 4U6CA 1A16A 4IKUA 4U69A 4IU6A 1YW8A 4S00A 2BWYA 1XGMA 5JHUA 2BHDA 3FMRA 3PKAA 5E2CA 5CE6A 1WY2A 2BWSA 2GG0A 4U75A 2Q8KA 3MX6A 3TB5A 3PKDA 1WKMA 2BHCA 2DFIA 2ZSGA 1YW7A 3IG4A 3TAVA 1B6AA 1R5HA 2Q93A 3IL0A 1W7VA 2GG7A 4RGZ1 1C21A 2BWUA 1C24A 2EVOA 2GU6A 2NQ7A 2OAZA 3FM3A 4JUQA 5FCFA 2EVMA 2P9AA 3L7GA 2BWWA 4ZNGA 2V6CA 4FLKA 4IKRA 4IKTA 4R60A 1C23A 2GU7A 2V3ZA 2B3KA 1KQ0A 3RVAA 1PV9A 1C27A 1QXWA 1XGSA 3IU7A 3CTZA 2GTXA 1BOAA 1M35A 4OOKA 3O5VA 4U70A 2ADUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PN9 A;  1XGN A;  4ZWO A;  3PKC A;  1WLR A;  4ZWU A;  2Q96 A;  2EA2 A;  2B3H A;  1WBQ A;  1MAT A;  4FO7 A;  1WL6 A;  4S2T P;  2BH3 A;  4MAT A;  4KM3 A;  3CB5 A;  4FO8 A;  3BIQ A;  4U76 A;  1R5G A;  2GG2 A;  2GG9 A;  2IW2 A;  1YW9 A;  4HXX A;  5FCH A;  3I7M A;  3PKB A;  1N51 A;  3OVK A;  3PEB A;  1Y1N A;  5CDE A;  4FLI A;  3CB6 A;  5CDL A;  2HOW A;  2GZ5 A;  2V3X A;  1QXZ A;  4PV4 A;  2Q92 A;  4PNC A;  1C22 A;  4RZY A;  5D6E A;  4FKC A;  2G6P A;  4B28 A;  2GG5 A;  3BIT A;  2BWV A;  3OOO A;  4RZZ A;  1O0X A;  4FLL A;  1W2M A;  4U6Z A;  2Q95 A;  3BIP A;  4U71 A;  3ROR A;  3S6B A;  2GU4 A;  2BHB A;  1QZY A;  5CIK A;  1YVM A;  4IDY A;  1YJ3 A;  3MR1 A;  4S01 A;  2MAT A;  4Z7M A;  2BWT A;  2BWX A;  4U1B A;  2BB7 A;  2B3L A;  4ZWP A;  4EGE A;  1XNZ A;  2GG3 A;  2GU5 A;  4A6V A;  5CLS A;  2NQ6 A;  3IU8 A;  3MAT A;  2V3Y A;  4A6W A;  2GGB A;  4U6J A;  2OKN A;  1R58 A;  1WN1 A;  1JAW A;  2P98 A;  4U6W A;  2GGC A;  4IKS A;  1KP0 A;  3D27 A;  4U6E A;  2GA2 A;  5E5B A;  1BN5 A;  4FUK A;  5D6F A;  3Q6D A;  1XGO A;  3PKE A;  4IF7 A;  2EA4 A;  2Q94 A;  2BN7 A;  4IEC A;  1B59 A;  3QOC A;  5CDV A;  4S2R P;  1QXY A;  5JI6 A;  2P99 A;  3FMQ A;  4QR8 A;  5CNX A;  5JFR A;  3IU9 A;  3L24 A;  4U73 A;  4IPA A;  2GG8 A;  1WL9 A;  1CHM A;  1KQ9 A;  2EVC A;  2BHA A;  4FLJ A;  4U6C A;  1A16 A;  4IKU A;  4U69 A;  4IU6 A;  1YW8 A;  4S00 A;  2BWY A;  1XGM A;  5JHU A;  2BHD A;  3FMR A;  3PKA A;  5E2C A;  5CE6 A;  1WY2 A;  2BWS A;  2GG0 A;  4U75 A;  2Q8K A;  3MX6 A;  3TB5 A;  3PKD A;  1WKM A;  2BHC A;  2DFI A;  2ZSG A;  1YW7 A;  3IG4 A;  3TAV A;  1B6A A;  1R5H A;  2Q93 A;  3IL0 A;  1W7V A;  2GG7 A;  4RGZ 1;  1C21 A;  2BWU A;  1C24 A;  2EVO A;  2GU6 A;  2NQ7 A;  2OAZ A;  3FM3 A;  4JUQ A;  5FCF A;  2EVM A;  2P9A A;  3L7G A;  2BWW A;  4ZNG A;  2V6C A;  4FLK A;  4IKR A;  4IKT A;  4R60 A;  1C23 A;  2GU7 A;  2V3Z A;  2B3K A;  1KQ0 A;  3RVA A;  1PV9 A;  1C27 A;  1QXW A;  1XGS A;  3IU7 A;  3CTZ A;  2GTX A;  1BOA A;  1M35 A;  4OOK A;  3O5V A;  4U70 A;  2ADU A; 
#chains in the Genus database with same CATH topology
 3PN9 A;  1XGN A;  4ZWO A;  3PKC A;  1WLR A;  4ZWU A;  2Q96 A;  2EA2 A;  2B3H A;  1WBQ A;  1MAT A;  4FO7 A;  1WL6 A;  4S2T P;  2BH3 A;  4MAT A;  4KM3 A;  3CB5 A;  4FO8 A;  3BIQ A;  4U76 A;  1R5G A;  2GG2 A;  2GG9 A;  2IW2 A;  1YW9 A;  4HXX A;  5FCH A;  3I7M A;  3PKB A;  1N51 A;  3OVK A;  3PEB A;  1Y1N A;  5CDE A;  4FLI A;  3CB6 A;  5CDL A;  2HOW A;  2GZ5 A;  2V3X A;  1QXZ A;  4PV4 A;  2Q92 A;  4PNC A;  1C22 A;  4RZY A;  5D6E A;  4FKC A;  2G6P A;  4B28 A;  2GG5 A;  3BIT A;  2BWV A;  3OOO A;  4RZZ A;  1O0X A;  4FLL A;  1W2M A;  4U6Z A;  2Q95 A;  3BIP A;  4U71 A;  3ROR A;  3S6B A;  2GU4 A;  2BHB A;  1QZY A;  5CIK A;  1YVM A;  4IDY A;  1YJ3 A;  3MR1 A;  4S01 A;  2MAT A;  4Z7M A;  2BWT A;  2BWX A;  4U1B A;  2BB7 A;  2B3L A;  4ZWP A;  4EGE A;  1XNZ A;  2GG3 A;  2GU5 A;  4A6V A;  5CLS A;  2NQ6 A;  3IU8 A;  3MAT A;  2V3Y A;  4A6W A;  2GGB A;  4U6J A;  2OKN A;  1R58 A;  1WN1 A;  1JAW A;  2P98 A;  4U6W A;  2GGC A;  4IKS A;  1KP0 A;  3D27 A;  4U6E A;  2GA2 A;  5E5B A;  1BN5 A;  4FUK A;  5D6F A;  3Q6D A;  1XGO A;  3PKE A;  4IF7 A;  2EA4 A;  2Q94 A;  2BN7 A;  4IEC A;  1B59 A;  3QOC A;  5CDV A;  4S2R P;  1QXY A;  5JI6 A;  2P99 A;  3FMQ A;  4QR8 A;  5CNX A;  5JFR A;  3IU9 A;  3L24 A;  4U73 A;  4IPA A;  2GG8 A;  1WL9 A;  1CHM A;  1KQ9 A;  2EVC A;  2BHA A;  4FLJ A;  4U6C A;  1A16 A;  4IKU A;  4U69 A;  4IU6 A;  1YW8 A;  4S00 A;  2BWY A;  1XGM A;  5JHU A;  2BHD A;  3FMR A;  3PKA A;  5E2C A;  5CE6 A;  1WY2 A;  2BWS A;  2GG0 A;  4U75 A;  2Q8K A;  3MX6 A;  3TB5 A;  3PKD A;  1WKM A;  2BHC A;  2DFI A;  2ZSG A;  1YW7 A;  3IG4 A;  3TAV A;  1B6A A;  1R5H A;  2Q93 A;  3IL0 A;  1W7V A;  2GG7 A;  4RGZ 1;  1C21 A;  2BWU A;  1C24 A;  2EVO A;  2GU6 A;  2NQ7 A;  2OAZ A;  3FM3 A;  4JUQ A;  5FCF A;  2EVM A;  2P9A A;  3L7G A;  2BWW A;  4ZNG A;  2V6C A;  4FLK A;  4IKR A;  4IKT A;  4R60 A;  1C23 A;  2GU7 A;  2V3Z A;  2B3K A;  1KQ0 A;  3RVA A;  1PV9 A;  1C27 A;  1QXW A;  1XGS A;  3IU7 A;  3CTZ A;  2GTX A;  1BOA A;  1M35 A;  4OOK A;  3O5V A;  4U70 A;  2ADU A; 
#chains in the Genus database with same CATH homology
 3PN9 A;  1XGN A;  4ZWO A;  3PKC A;  1WLR A;  4ZWU A;  2Q96 A;  2EA2 A;  2B3H A;  1WBQ A;  1MAT A;  4FO7 A;  1WL6 A;  4S2T P;  2BH3 A;  4MAT A;  4KM3 A;  3CB5 A;  4FO8 A;  3BIQ A;  4U76 A;  1R5G A;  2GG2 A;  2GG9 A;  2IW2 A;  1YW9 A;  4HXX A;  5FCH A;  3I7M A;  3PKB A;  1N51 A;  3OVK A;  3PEB A;  1Y1N A;  5CDE A;  4FLI A;  3CB6 A;  5CDL A;  2HOW A;  2GZ5 A;  2V3X A;  1QXZ A;  4PV4 A;  2Q92 A;  4PNC A;  1C22 A;  4RZY A;  5D6E A;  4FKC A;  2G6P A;  4B28 A;  2GG5 A;  3BIT A;  2BWV A;  3OOO A;  4RZZ A;  1O0X A;  4FLL A;  1W2M A;  4U6Z A;  2Q95 A;  3BIP A;  4U71 A;  3ROR A;  3S6B A;  2GU4 A;  2BHB A;  1QZY A;  5CIK A;  1YVM A;  4IDY A;  1YJ3 A;  3MR1 A;  4S01 A;  2MAT A;  4Z7M A;  2BWT A;  2BWX A;  4U1B A;  2BB7 A;  2B3L A;  4ZWP A;  4EGE A;  1XNZ A;  2GG3 A;  2GU5 A;  4A6V A;  5CLS A;  2NQ6 A;  3IU8 A;  3MAT A;  2V3Y A;  4A6W A;  2GGB A;  4U6J A;  2OKN A;  1R58 A;  1WN1 A;  1JAW A;  2P98 A;  4U6W A;  2GGC A;  4IKS A;  1KP0 A;  3D27 A;  4U6E A;  2GA2 A;  5E5B A;  1BN5 A;  4FUK A;  5D6F A;  3Q6D A;  1XGO A;  3PKE A;  4IF7 A;  2EA4 A;  2Q94 A;  2BN7 A;  4IEC A;  1B59 A;  3QOC A;  5CDV A;  4S2R P;  1QXY A;  5JI6 A;  2P99 A;  3FMQ A;  4QR8 A;  5CNX A;  5JFR A;  3IU9 A;  3L24 A;  4U73 A;  4IPA A;  2GG8 A;  1WL9 A;  1CHM A;  1KQ9 A;  2EVC A;  2BHA A;  4FLJ A;  4U6C A;  1A16 A;  4IKU A;  4U69 A;  4IU6 A;  1YW8 A;  4S00 A;  2BWY A;  1XGM A;  5JHU A;  2BHD A;  3FMR A;  3PKA A;  5E2C A;  5CE6 A;  1WY2 A;  2BWS A;  2GG0 A;  4U75 A;  2Q8K A;  3MX6 A;  3TB5 A;  3PKD A;  1WKM A;  2BHC A;  2DFI A;  2ZSG A;  1YW7 A;  3IG4 A;  3TAV A;  1B6A A;  1R5H A;  2Q93 A;  3IL0 A;  1W7V A;  2GG7 A;  4RGZ 1;  1C21 A;  2BWU A;  1C24 A;  2EVO A;  2GU6 A;  2NQ7 A;  2OAZ A;  3FM3 A;  4JUQ A;  5FCF A;  2EVM A;  2P9A A;  3L7G A;  2BWW A;  4ZNG A;  2V6C A;  4FLK A;  4IKR A;  4IKT A;  4R60 A;  1C23 A;  2GU7 A;  2V3Z A;  2B3K A;  1KQ0 A;  3RVA A;  1PV9 A;  1C27 A;  1QXW A;  1XGS A;  3IU7 A;  3CTZ A;  2GTX A;  1BOA A;  1M35 A;  4OOK A;  3O5V A;  4U70 A;  2ADU A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...