2OKNA

Crystal strcture of human prolidase
Total Genus 160
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
sequence length
477
structure length
477
Chain Sequence
GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Xaa-Pro dipeptidase
publication title Crystal Structure of Human Prolidase: The Molecular Basis of PD Disease.
rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 160
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2007-01-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2oknA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2oknA02
2BWSA 5D6EA 1W7VA 4FLIA 5JI6A 5JFRA 1PV9A 2B3LA 2GG5A 1XGMA 2V3YA 5CIKA 5CDEA 1KQ9A 1QXYA 1KP0A 2HOWA 1R5HA 2GU7A 3PKEA 4IDYA 2DFIA 5CDLA 4JUQA 2ZSGA 2Q93A 2BHDA 2GG8A 2MATA 3MATA 4IKRA 4IKSA 2GU4A 1BN5A 2BHAA 2GZ5A 3RVAA 2BWVA 3CB5A 4FO8A 3L7GA 1WLRA 1MATA 2ADUA 1YW8A 4QR8A 1YW9A 3QOCA 3IG4A 1WN1A 3FM3A 4B28A 2V3XA 1CHMA 4Z7MA 2OKNA 3IU9A 2BHCA 4R60A 1N51A 2V3ZA 5D6FA 4FUKA 4U6ZA 1XGNA 4U6EA 2P98A 2B3KA 4RZZA 1WL6A 2Q95A 3FMQA 4MATA 4OOKA 4A6WA 3BIQA 1XNZA 4ZWOA 1O0XA 1B6AA 3O5VA 2BHBA 1C22A 1WBQA 2NQ6A 4U75A 5CLSA 1R58A 5E2CA 1A16A 3L24A 2IW2A 3OOOA 2V6CA 4S2TP 3IL0A 4ZWUA 1JAWA 3PKBA 2GG9A 2Q96A 4U6CA 1YVMA 3D27A 4RZYA 1R5GA 3PKDA 4RGZ1 2EVOA 2GA2A 3Q6DA 4ZNGA 5E5BA 2GG0A 3IU7A 1W2MA 2BWYA 1C24A 1QXWA 1QZYA 4FLJA 2G6PA 4IPAA 2B3HA 4IF7A 2EA4A 2GGCA 4A6VA 4FKCA 2GU6A 1C21A 1YJ3A 3PN9A 3TAVA 3OVKA 2OAZA 4U69A 2EVCA 2EVMA 2GG3A 2P99A 1YW7A 4S2RP 3PKCA 2GU5A 3MR1A 4S01A 4U1BA 4U71A 2BH3A 5CE6A 1M35A 3CTZA 2BWXA 5CNXA 4U6JA 5CDVA 2BWTA 3BIPA 5FCFA 2GG2A 1WY2A 4U76A 2BWWA 4IU6A 1KQ0A 1C27A 3PKAA 4FLKA 4FO7A 2NQ7A 3RORA 4U73A 2EA2A 2GGBA 3FMRA 3I7MA 1QXZA 4HXXA 1WKMA 1B59A 2GTXA 3BITA 2BB7A 1WL9A 1C23A 3TB5A 3MX6A 4IKTA 3S6BA 2BN7A 4U6WA 3CB6A 3PEBA 4FLLA 1BOAA 1XGSA 4U70A 4KM3A 4PV4A 4IKUA 5FCHA 1Y1NA 1XGOA 2Q94A 3IU8A 4IECA 5JHUA 4PNCA 4EGEA 2P9AA 2Q8KA 4S00A 2Q92A 2GG7A 4ZWPA 2BWUA
chains in the Genus database with same CATH superfamily
2BWSA 5D6EA 1W7VA 4FLIA 5JI6A 5JFRA 1PV9A 2B3LA 2GG5A 1XGMA 2V3YA 5CIKA 5CDEA 1KQ9A 1QXYA 1KP0A 2HOWA 1R5HA 2GU7A 3PKEA 4IDYA 2DFIA 5CDLA 4JUQA 2ZSGA 2Q93A 2BHDA 2GG8A 2MATA 3MATA 4IKRA 4IKSA 2GU4A 1BN5A 2BHAA 2GZ5A 3RVAA 2BWVA 3CB5A 4FO8A 3L7GA 1WLRA 1MATA 2ADUA 1YW8A 4QR8A 1YW9A 3QOCA 3IG4A 1WN1A 3FM3A 4B28A 2V3XA 1CHMA 4Z7MA 2OKNA 3IU9A 2BHCA 4R60A 1N51A 2V3ZA 5D6FA 4FUKA 4U6ZA 1XGNA 4U6EA 2P98A 2B3KA 4RZZA 1WL6A 2Q95A 3FMQA 4MATA 4OOKA 4A6WA 3BIQA 1XNZA 4ZWOA 1O0XA 1B6AA 3O5VA 2BHBA 1C22A 1WBQA 2NQ6A 4U75A 5CLSA 1R58A 5E2CA 1A16A 3L24A 2IW2A 3OOOA 2V6CA 4S2TP 3IL0A 4ZWUA 1JAWA 3PKBA 2GG9A 2Q96A 4U6CA 1YVMA 3D27A 4RZYA 1R5GA 3PKDA 4RGZ1 2EVOA 2GA2A 3Q6DA 4ZNGA 5E5BA 2GG0A 3IU7A 1W2MA 2BWYA 1C24A 1QXWA 1QZYA 4FLJA 2G6PA 4IPAA 2B3HA 4IF7A 2EA4A 2GGCA 4A6VA 4FKCA 2GU6A 1C21A 1YJ3A 3PN9A 3TAVA 3OVKA 2OAZA 4U69A 2EVCA 2EVMA 2GG3A 2P99A 1YW7A 4S2RP 3PKCA 2GU5A 3MR1A 4S01A 4U1BA 4U71A 2BH3A 5CE6A 1M35A 3CTZA 2BWXA 5CNXA 4U6JA 5CDVA 2BWTA 3BIPA 5FCFA 2GG2A 1WY2A 4U76A 2BWWA 4IU6A 1KQ0A 1C27A 3PKAA 4FLKA 4FO7A 2NQ7A 3RORA 4U73A 2EA2A 2GGBA 3FMRA 3I7MA 1QXZA 4HXXA 1WKMA 1B59A 2GTXA 3BITA 2BB7A 1WL9A 1C23A 3TB5A 3MX6A 4IKTA 3S6BA 2BN7A 4U6WA 3CB6A 3PEBA 4FLLA 1BOAA 1XGSA 4U70A 4KM3A 4PV4A 4IKUA 5FCHA 1Y1NA 1XGOA 2Q94A 3IU8A 4IECA 5JHUA 4PNCA 4EGEA 2P9AA 2Q8KA 4S00A 2Q92A 2GG7A 4ZWPA 2BWUA
chains in the Genus database with same CATH topology
2BWSA 5D6EA 1W7VA 4FLIA 5JI6A 5JFRA 1PV9A 2B3LA 2GG5A 1XGMA 2V3YA 5CIKA 5CDEA 1KQ9A 1QXYA 1KP0A 2HOWA 1R5HA 2GU7A 3PKEA 4IDYA 2DFIA 5CDLA 4JUQA 2ZSGA 2Q93A 2BHDA 2GG8A 2MATA 3MATA 4IKRA 4IKSA 2GU4A 1BN5A 2BHAA 2GZ5A 3RVAA 2BWVA 3CB5A 4FO8A 3L7GA 1WLRA 1MATA 2ADUA 1YW8A 4QR8A 1YW9A 3QOCA 3IG4A 1WN1A 3FM3A 4B28A 2V3XA 1CHMA 4Z7MA 2OKNA 3IU9A 2BHCA 4R60A 1N51A 2V3ZA 5D6FA 4FUKA 4U6ZA 1XGNA 4U6EA 2P98A 2B3KA 4RZZA 1WL6A 2Q95A 3FMQA 4MATA 4OOKA 4A6WA 3BIQA 1XNZA 4ZWOA 1O0XA 1B6AA 3O5VA 2BHBA 1C22A 1WBQA 2NQ6A 4U75A 5CLSA 1R58A 5E2CA 1A16A 3L24A 2IW2A 3OOOA 2V6CA 4S2TP 3IL0A 4ZWUA 1JAWA 3PKBA 2GG9A 2Q96A 4U6CA 1YVMA 3D27A 4RZYA 1R5GA 3PKDA 4RGZ1 2EVOA 2GA2A 3Q6DA 4ZNGA 5E5BA 2GG0A 3IU7A 1W2MA 2BWYA 1C24A 1QXWA 1QZYA 4FLJA 2G6PA 4IPAA 2B3HA 4IF7A 2EA4A 2GGCA 4A6VA 4FKCA 2GU6A 1C21A 1YJ3A 3PN9A 3TAVA 3OVKA 2OAZA 4U69A 2EVCA 2EVMA 2GG3A 2P99A 1YW7A 4S2RP 3PKCA 2GU5A 3MR1A 4S01A 4U1BA 4U71A 2BH3A 5CE6A 1M35A 3CTZA 2BWXA 5CNXA 4U6JA 5CDVA 2BWTA 3BIPA 5FCFA 2GG2A 1WY2A 4U76A 2BWWA 4IU6A 1KQ0A 1C27A 3PKAA 4FLKA 4FO7A 2NQ7A 3RORA 4U73A 2EA2A 2GGBA 3FMRA 3I7MA 1QXZA 4HXXA 1WKMA 1B59A 2GTXA 3BITA 2BB7A 1WL9A 1C23A 3TB5A 3MX6A 4IKTA 3S6BA 2BN7A 4U6WA 3CB6A 3PEBA 4FLLA 1BOAA 1XGSA 4U70A 4KM3A 4PV4A 4IKUA 5FCHA 1Y1NA 1XGOA 2Q94A 3IU8A 4IECA 5JHUA 4PNCA 4EGEA 2P9AA 2Q8KA 4S00A 2Q92A 2GG7A 4ZWPA 2BWUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BWS A;  5D6E A;  1W7V A;  4FLI A;  5JI6 A;  5JFR A;  1PV9 A;  2B3L A;  2GG5 A;  1XGM A;  2V3Y A;  5CIK A;  5CDE A;  1KQ9 A;  1QXY A;  1KP0 A;  2HOW A;  1R5H A;  2GU7 A;  3PKE A;  4IDY A;  2DFI A;  5CDL A;  4JUQ A;  2ZSG A;  2Q93 A;  2BHD A;  2GG8 A;  2MAT A;  3MAT A;  4IKR A;  4IKS A;  2GU4 A;  1BN5 A;  2BHA A;  2GZ5 A;  3RVA A;  2BWV A;  3CB5 A;  4FO8 A;  3L7G A;  1WLR A;  1MAT A;  2ADU A;  1YW8 A;  4QR8 A;  1YW9 A;  3QOC A;  3IG4 A;  1WN1 A;  3FM3 A;  4B28 A;  2V3X A;  1CHM A;  4Z7M A;  2OKN A;  3IU9 A;  2BHC A;  4R60 A;  1N51 A;  2V3Z A;  5D6F A;  4FUK A;  4U6Z A;  1XGN A;  4U6E A;  2P98 A;  2B3K A;  4RZZ A;  1WL6 A;  2Q95 A;  3FMQ A;  4MAT A;  4OOK A;  4A6W A;  3BIQ A;  1XNZ A;  4ZWO A;  1O0X A;  1B6A A;  3O5V A;  2BHB A;  1C22 A;  1WBQ A;  2NQ6 A;  4U75 A;  5CLS A;  1R58 A;  5E2C A;  1A16 A;  3L24 A;  2IW2 A;  3OOO A;  2V6C A;  4S2T P;  3IL0 A;  4ZWU A;  1JAW A;  3PKB A;  2GG9 A;  2Q96 A;  4U6C A;  1YVM A;  3D27 A;  4RZY A;  1R5G A;  3PKD A;  4RGZ 1;  2EVO A;  2GA2 A;  3Q6D A;  4ZNG A;  5E5B A;  2GG0 A;  3IU7 A;  1W2M A;  2BWY A;  1C24 A;  1QXW A;  1QZY A;  4FLJ A;  2G6P A;  4IPA A;  2B3H A;  4IF7 A;  2EA4 A;  2GGC A;  4A6V A;  4FKC A;  2GU6 A;  1C21 A;  1YJ3 A;  3PN9 A;  3TAV A;  3OVK A;  2OAZ A;  4U69 A;  2EVC A;  2EVM A;  2GG3 A;  2P99 A;  1YW7 A;  4S2R P;  3PKC A;  2GU5 A;  3MR1 A;  4S01 A;  4U1B A;  4U71 A;  2BH3 A;  5CE6 A;  1M35 A;  3CTZ A;  2BWX A;  5CNX A;  4U6J A;  5CDV A;  2BWT A;  3BIP A;  5FCF A;  2GG2 A;  1WY2 A;  4U76 A;  2BWW A;  4IU6 A;  1KQ0 A;  1C27 A;  3PKA A;  4FLK A;  4FO7 A;  2NQ7 A;  3ROR A;  4U73 A;  2EA2 A;  2GGB A;  3FMR A;  3I7M A;  1QXZ A;  4HXX A;  1WKM A;  1B59 A;  2GTX A;  3BIT A;  2BB7 A;  1WL9 A;  1C23 A;  3TB5 A;  3MX6 A;  4IKT A;  3S6B A;  2BN7 A;  4U6W A;  3CB6 A;  3PEB A;  4FLL A;  1BOA A;  1XGS A;  4U70 A;  4KM3 A;  4PV4 A;  4IKU A;  5FCH A;  1Y1N A;  1XGO A;  2Q94 A;  3IU8 A;  4IEC A;  5JHU A;  4PNC A;  4EGE A;  2P9A A;  2Q8K A;  4S00 A;  2Q92 A;  2GG7 A;  4ZWP A;  2BWU A; 
#chains in the Genus database with same CATH topology
 2BWS A;  5D6E A;  1W7V A;  4FLI A;  5JI6 A;  5JFR A;  1PV9 A;  2B3L A;  2GG5 A;  1XGM A;  2V3Y A;  5CIK A;  5CDE A;  1KQ9 A;  1QXY A;  1KP0 A;  2HOW A;  1R5H A;  2GU7 A;  3PKE A;  4IDY A;  2DFI A;  5CDL A;  4JUQ A;  2ZSG A;  2Q93 A;  2BHD A;  2GG8 A;  2MAT A;  3MAT A;  4IKR A;  4IKS A;  2GU4 A;  1BN5 A;  2BHA A;  2GZ5 A;  3RVA A;  2BWV A;  3CB5 A;  4FO8 A;  3L7G A;  1WLR A;  1MAT A;  2ADU A;  1YW8 A;  4QR8 A;  1YW9 A;  3QOC A;  3IG4 A;  1WN1 A;  3FM3 A;  4B28 A;  2V3X A;  1CHM A;  4Z7M A;  2OKN A;  3IU9 A;  2BHC A;  4R60 A;  1N51 A;  2V3Z A;  5D6F A;  4FUK A;  4U6Z A;  1XGN A;  4U6E A;  2P98 A;  2B3K A;  4RZZ A;  1WL6 A;  2Q95 A;  3FMQ A;  4MAT A;  4OOK A;  4A6W A;  3BIQ A;  1XNZ A;  4ZWO A;  1O0X A;  1B6A A;  3O5V A;  2BHB A;  1C22 A;  1WBQ A;  2NQ6 A;  4U75 A;  5CLS A;  1R58 A;  5E2C A;  1A16 A;  3L24 A;  2IW2 A;  3OOO A;  2V6C A;  4S2T P;  3IL0 A;  4ZWU A;  1JAW A;  3PKB A;  2GG9 A;  2Q96 A;  4U6C A;  1YVM A;  3D27 A;  4RZY A;  1R5G A;  3PKD A;  4RGZ 1;  2EVO A;  2GA2 A;  3Q6D A;  4ZNG A;  5E5B A;  2GG0 A;  3IU7 A;  1W2M A;  2BWY A;  1C24 A;  1QXW A;  1QZY A;  4FLJ A;  2G6P A;  4IPA A;  2B3H A;  4IF7 A;  2EA4 A;  2GGC A;  4A6V A;  4FKC A;  2GU6 A;  1C21 A;  1YJ3 A;  3PN9 A;  3TAV A;  3OVK A;  2OAZ A;  4U69 A;  2EVC A;  2EVM A;  2GG3 A;  2P99 A;  1YW7 A;  4S2R P;  3PKC A;  2GU5 A;  3MR1 A;  4S01 A;  4U1B A;  4U71 A;  2BH3 A;  5CE6 A;  1M35 A;  3CTZ A;  2BWX A;  5CNX A;  4U6J A;  5CDV A;  2BWT A;  3BIP A;  5FCF A;  2GG2 A;  1WY2 A;  4U76 A;  2BWW A;  4IU6 A;  1KQ0 A;  1C27 A;  3PKA A;  4FLK A;  4FO7 A;  2NQ7 A;  3ROR A;  4U73 A;  2EA2 A;  2GGB A;  3FMR A;  3I7M A;  1QXZ A;  4HXX A;  1WKM A;  1B59 A;  2GTX A;  3BIT A;  2BB7 A;  1WL9 A;  1C23 A;  3TB5 A;  3MX6 A;  4IKT A;  3S6B A;  2BN7 A;  4U6W A;  3CB6 A;  3PEB A;  4FLL A;  1BOA A;  1XGS A;  4U70 A;  4KM3 A;  4PV4 A;  4IKU A;  5FCH A;  1Y1N A;  1XGO A;  2Q94 A;  3IU8 A;  4IEC A;  5JHU A;  4PNC A;  4EGE A;  2P9A A;  2Q8K A;  4S00 A;  2Q92 A;  2GG7 A;  4ZWP A;  2BWU A; 
#chains in the Genus database with same CATH homology
 2BWS A;  5D6E A;  1W7V A;  4FLI A;  5JI6 A;  5JFR A;  1PV9 A;  2B3L A;  2GG5 A;  1XGM A;  2V3Y A;  5CIK A;  5CDE A;  1KQ9 A;  1QXY A;  1KP0 A;  2HOW A;  1R5H A;  2GU7 A;  3PKE A;  4IDY A;  2DFI A;  5CDL A;  4JUQ A;  2ZSG A;  2Q93 A;  2BHD A;  2GG8 A;  2MAT A;  3MAT A;  4IKR A;  4IKS A;  2GU4 A;  1BN5 A;  2BHA A;  2GZ5 A;  3RVA A;  2BWV A;  3CB5 A;  4FO8 A;  3L7G A;  1WLR A;  1MAT A;  2ADU A;  1YW8 A;  4QR8 A;  1YW9 A;  3QOC A;  3IG4 A;  1WN1 A;  3FM3 A;  4B28 A;  2V3X A;  1CHM A;  4Z7M A;  2OKN A;  3IU9 A;  2BHC A;  4R60 A;  1N51 A;  2V3Z A;  5D6F A;  4FUK A;  4U6Z A;  1XGN A;  4U6E A;  2P98 A;  2B3K A;  4RZZ A;  1WL6 A;  2Q95 A;  3FMQ A;  4MAT A;  4OOK A;  4A6W A;  3BIQ A;  1XNZ A;  4ZWO A;  1O0X A;  1B6A A;  3O5V A;  2BHB A;  1C22 A;  1WBQ A;  2NQ6 A;  4U75 A;  5CLS A;  1R58 A;  5E2C A;  1A16 A;  3L24 A;  2IW2 A;  3OOO A;  2V6C A;  4S2T P;  3IL0 A;  4ZWU A;  1JAW A;  3PKB A;  2GG9 A;  2Q96 A;  4U6C A;  1YVM A;  3D27 A;  4RZY A;  1R5G A;  3PKD A;  4RGZ 1;  2EVO A;  2GA2 A;  3Q6D A;  4ZNG A;  5E5B A;  2GG0 A;  3IU7 A;  1W2M A;  2BWY A;  1C24 A;  1QXW A;  1QZY A;  4FLJ A;  2G6P A;  4IPA A;  2B3H A;  4IF7 A;  2EA4 A;  2GGC A;  4A6V A;  4FKC A;  2GU6 A;  1C21 A;  1YJ3 A;  3PN9 A;  3TAV A;  3OVK A;  2OAZ A;  4U69 A;  2EVC A;  2EVM A;  2GG3 A;  2P99 A;  1YW7 A;  4S2R P;  3PKC A;  2GU5 A;  3MR1 A;  4S01 A;  4U1B A;  4U71 A;  2BH3 A;  5CE6 A;  1M35 A;  3CTZ A;  2BWX A;  5CNX A;  4U6J A;  5CDV A;  2BWT A;  3BIP A;  5FCF A;  2GG2 A;  1WY2 A;  4U76 A;  2BWW A;  4IU6 A;  1KQ0 A;  1C27 A;  3PKA A;  4FLK A;  4FO7 A;  2NQ7 A;  3ROR A;  4U73 A;  2EA2 A;  2GGB A;  3FMR A;  3I7M A;  1QXZ A;  4HXX A;  1WKM A;  1B59 A;  2GTX A;  3BIT A;  2BB7 A;  1WL9 A;  1C23 A;  3TB5 A;  3MX6 A;  4IKT A;  3S6B A;  2BN7 A;  4U6W A;  3CB6 A;  3PEB A;  4FLL A;  1BOA A;  1XGS A;  4U70 A;  4KM3 A;  4PV4 A;  4IKU A;  5FCH A;  1Y1N A;  1XGO A;  2Q94 A;  3IU8 A;  4IEC A;  5JHU A;  4PNC A;  4EGE A;  2P9A A;  2Q8K A;  4S00 A;  2Q92 A;  2GG7 A;  4ZWP A;  2BWU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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