2OKNA

Crystal strcture of human prolidase
Total Genus 160
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
sequence length
477
structure length
477
Chain Sequence
GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Xaa-Pro dipeptidase
publication title Crystal Structure of Human Prolidase: The Molecular Basis of PD Disease.
rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 160
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2007-01-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2oknA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2oknA02
4OOKA 5CNXA 1BN5A 5CLSA 2EVMA 3TAVA 3L24A 3OVKA 4IDYA 2P99A 5E2CA 2GG8A 2Q93A 4U73A 4FLJA 1QXWA 4IKUA 3PEBA 4S01A 1WLRA 4A6WA 1W7VA 5CIKA 2NQ6A 2IW2A 2BWXA 5CDVA 2GGCA 4S2TP 2Q96A 2BHBA 3IU8A 2V3ZA 4MATA 4U6ZA 1M35A 2BWYA 4IF7A 1C23A 4IECA 4IPAA 4U76A 1C21A 2BWVA 4FO7A 4U1BA 4ZWPA 2OAZA 3PKEA 2GGBA 1WN1A 2EA4A 4ZWUA 2GG5A 4U6EA 1C27A 1N51A 5FCFA 3FMRA 2GA2A 4R60A 2BN7A 3MX6A 4U75A 2EVOA 4PNCA 2GU5A 2B3KA 4FLKA 4FO8A 1XNZA 1CHMA 2BWWA 2MATA 2V3XA 4IKRA 4S2RP 1YVMA 3RORA 1R5HA 5JI6A 4PV4A 3IL0A 2GTXA 2GG2A 4U71A 2BHCA 1BOAA 1YW7A 2BB7A 5D6EA 1O0XA 5E5BA 3PKDA 2BWSA 4U6WA 5D6FA 2BHDA 1JAWA 2GU6A 3BITA 1W2MA 4FUKA 3CB5A 1XGSA 3IG4A 4IKTA 4U70A 4JUQA 4ZWOA 3BIPA 1C22A 2GG7A 1R58A 2GU7A 5FCHA 1WL6A 1WL9A 1QZYA 1YW9A 3MR1A 1Y1NA 1KQ0A 1KP0A 4U69A 2B3LA 3PKAA 4S00A 2BWTA 3IU7A 3PKCA 2HOWA 2GG3A 2BH3A 5CDEA 1B6AA 3IU9A 4FLLA 4RGZ1 4FKCA 1XGMA 2GG9A 2EVCA 3PN9A 1A16A 3D27A 1YJ3A 2BWUA 1PV9A 3I7MA 5CE6A 1C24A 1B59A 2V3YA 1MATA 1YW8A 4IKSA 4IU6A 4EGEA 4U6CA 4QR8A 2NQ7A 3MATA 2Q94A 5JFRA 2ADUA 4RZZA 4B28A 1WKMA 3L7GA 2P9AA 1XGNA 1R5GA 2Q92A 4HXXA 3PKBA 4ZNGA 2G6PA 3O5VA 4FLIA 2V6CA 3S6BA 4Z7MA 2GZ5A 3FMQA 3OOOA 2P98A 2Q95A 3BIQA 2OKNA 2B3HA 3TB5A 5JHUA 2DFIA 2GG0A 2BHAA 3CB6A 1XGOA 2GU4A 2Q8KA 1QXYA 4U6JA 1WBQA 1QXZA 3FM3A 2EA2A 3Q6DA 1KQ9A 1WY2A 4A6VA 4RZYA 2ZSGA 4KM3A 5CDLA 3CTZA 3RVAA 3QOCA
chains in the Genus database with same CATH superfamily
4OOKA 5CNXA 1BN5A 5CLSA 2EVMA 3TAVA 3L24A 3OVKA 4IDYA 2P99A 5E2CA 2GG8A 2Q93A 4U73A 4FLJA 1QXWA 4IKUA 3PEBA 4S01A 1WLRA 4A6WA 1W7VA 5CIKA 2NQ6A 2IW2A 2BWXA 5CDVA 2GGCA 4S2TP 2Q96A 2BHBA 3IU8A 2V3ZA 4MATA 4U6ZA 1M35A 2BWYA 4IF7A 1C23A 4IECA 4IPAA 4U76A 1C21A 2BWVA 4FO7A 4U1BA 4ZWPA 2OAZA 3PKEA 2GGBA 1WN1A 2EA4A 4ZWUA 2GG5A 4U6EA 1C27A 1N51A 5FCFA 3FMRA 2GA2A 4R60A 2BN7A 3MX6A 4U75A 2EVOA 4PNCA 2GU5A 2B3KA 4FLKA 4FO8A 1XNZA 1CHMA 2BWWA 2MATA 2V3XA 4IKRA 4S2RP 1YVMA 3RORA 1R5HA 5JI6A 4PV4A 3IL0A 2GTXA 2GG2A 4U71A 2BHCA 1BOAA 1YW7A 2BB7A 5D6EA 1O0XA 5E5BA 3PKDA 2BWSA 4U6WA 5D6FA 2BHDA 1JAWA 2GU6A 3BITA 1W2MA 4FUKA 3CB5A 1XGSA 3IG4A 4IKTA 4U70A 4JUQA 4ZWOA 3BIPA 1C22A 2GG7A 1R58A 2GU7A 5FCHA 1WL6A 1WL9A 1QZYA 1YW9A 3MR1A 1Y1NA 1KQ0A 1KP0A 4U69A 2B3LA 3PKAA 4S00A 2BWTA 3IU7A 3PKCA 2HOWA 2GG3A 2BH3A 5CDEA 1B6AA 3IU9A 4FLLA 4RGZ1 4FKCA 1XGMA 2GG9A 2EVCA 3PN9A 1A16A 3D27A 1YJ3A 2BWUA 1PV9A 3I7MA 5CE6A 1C24A 1B59A 2V3YA 1MATA 1YW8A 4IKSA 4IU6A 4EGEA 4U6CA 4QR8A 2NQ7A 3MATA 2Q94A 5JFRA 2ADUA 4RZZA 4B28A 1WKMA 3L7GA 2P9AA 1XGNA 1R5GA 2Q92A 4HXXA 3PKBA 4ZNGA 2G6PA 3O5VA 4FLIA 2V6CA 3S6BA 4Z7MA 2GZ5A 3FMQA 3OOOA 2P98A 2Q95A 3BIQA 2OKNA 2B3HA 3TB5A 5JHUA 2DFIA 2GG0A 2BHAA 3CB6A 1XGOA 2GU4A 2Q8KA 1QXYA 4U6JA 1WBQA 1QXZA 3FM3A 2EA2A 3Q6DA 1KQ9A 1WY2A 4A6VA 4RZYA 2ZSGA 4KM3A 5CDLA 3CTZA 3RVAA 3QOCA
chains in the Genus database with same CATH topology
4OOKA 5CNXA 1BN5A 5CLSA 2EVMA 3TAVA 3L24A 3OVKA 4IDYA 2P99A 5E2CA 2GG8A 2Q93A 4U73A 4FLJA 1QXWA 4IKUA 3PEBA 4S01A 1WLRA 4A6WA 1W7VA 5CIKA 2NQ6A 2IW2A 2BWXA 5CDVA 2GGCA 4S2TP 2Q96A 2BHBA 3IU8A 2V3ZA 4MATA 4U6ZA 1M35A 2BWYA 4IF7A 1C23A 4IECA 4IPAA 4U76A 1C21A 2BWVA 4FO7A 4U1BA 4ZWPA 2OAZA 3PKEA 2GGBA 1WN1A 2EA4A 4ZWUA 2GG5A 4U6EA 1C27A 1N51A 5FCFA 3FMRA 2GA2A 4R60A 2BN7A 3MX6A 4U75A 2EVOA 4PNCA 2GU5A 2B3KA 4FLKA 4FO8A 1XNZA 1CHMA 2BWWA 2MATA 2V3XA 4IKRA 4S2RP 1YVMA 3RORA 1R5HA 5JI6A 4PV4A 3IL0A 2GTXA 2GG2A 4U71A 2BHCA 1BOAA 1YW7A 2BB7A 5D6EA 1O0XA 5E5BA 3PKDA 2BWSA 4U6WA 5D6FA 2BHDA 1JAWA 2GU6A 3BITA 1W2MA 4FUKA 3CB5A 1XGSA 3IG4A 4IKTA 4U70A 4JUQA 4ZWOA 3BIPA 1C22A 2GG7A 1R58A 2GU7A 5FCHA 1WL6A 1WL9A 1QZYA 1YW9A 3MR1A 1Y1NA 1KQ0A 1KP0A 4U69A 2B3LA 3PKAA 4S00A 2BWTA 3IU7A 3PKCA 2HOWA 2GG3A 2BH3A 5CDEA 1B6AA 3IU9A 4FLLA 4RGZ1 4FKCA 1XGMA 2GG9A 2EVCA 3PN9A 1A16A 3D27A 1YJ3A 2BWUA 1PV9A 3I7MA 5CE6A 1C24A 1B59A 2V3YA 1MATA 1YW8A 4IKSA 4IU6A 4EGEA 4U6CA 4QR8A 2NQ7A 3MATA 2Q94A 5JFRA 2ADUA 4RZZA 4B28A 1WKMA 3L7GA 2P9AA 1XGNA 1R5GA 2Q92A 4HXXA 3PKBA 4ZNGA 2G6PA 3O5VA 4FLIA 2V6CA 3S6BA 4Z7MA 2GZ5A 3FMQA 3OOOA 2P98A 2Q95A 3BIQA 2OKNA 2B3HA 3TB5A 5JHUA 2DFIA 2GG0A 2BHAA 3CB6A 1XGOA 2GU4A 2Q8KA 1QXYA 4U6JA 1WBQA 1QXZA 3FM3A 2EA2A 3Q6DA 1KQ9A 1WY2A 4A6VA 4RZYA 2ZSGA 4KM3A 5CDLA 3CTZA 3RVAA 3QOCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OOK A;  5CNX A;  1BN5 A;  5CLS A;  2EVM A;  3TAV A;  3L24 A;  3OVK A;  4IDY A;  2P99 A;  5E2C A;  2GG8 A;  2Q93 A;  4U73 A;  4FLJ A;  1QXW A;  4IKU A;  3PEB A;  4S01 A;  1WLR A;  4A6W A;  1W7V A;  5CIK A;  2NQ6 A;  2IW2 A;  2BWX A;  5CDV A;  2GGC A;  4S2T P;  2Q96 A;  2BHB A;  3IU8 A;  2V3Z A;  4MAT A;  4U6Z A;  1M35 A;  2BWY A;  4IF7 A;  1C23 A;  4IEC A;  4IPA A;  4U76 A;  1C21 A;  2BWV A;  4FO7 A;  4U1B A;  4ZWP A;  2OAZ A;  3PKE A;  2GGB A;  1WN1 A;  2EA4 A;  4ZWU A;  2GG5 A;  4U6E A;  1C27 A;  1N51 A;  5FCF A;  3FMR A;  2GA2 A;  4R60 A;  2BN7 A;  3MX6 A;  4U75 A;  2EVO A;  4PNC A;  2GU5 A;  2B3K A;  4FLK A;  4FO8 A;  1XNZ A;  1CHM A;  2BWW A;  2MAT A;  2V3X A;  4IKR A;  4S2R P;  1YVM A;  3ROR A;  1R5H A;  5JI6 A;  4PV4 A;  3IL0 A;  2GTX A;  2GG2 A;  4U71 A;  2BHC A;  1BOA A;  1YW7 A;  2BB7 A;  5D6E A;  1O0X A;  5E5B A;  3PKD A;  2BWS A;  4U6W A;  5D6F A;  2BHD A;  1JAW A;  2GU6 A;  3BIT A;  1W2M A;  4FUK A;  3CB5 A;  1XGS A;  3IG4 A;  4IKT A;  4U70 A;  4JUQ A;  4ZWO A;  3BIP A;  1C22 A;  2GG7 A;  1R58 A;  2GU7 A;  5FCH A;  1WL6 A;  1WL9 A;  1QZY A;  1YW9 A;  3MR1 A;  1Y1N A;  1KQ0 A;  1KP0 A;  4U69 A;  2B3L A;  3PKA A;  4S00 A;  2BWT A;  3IU7 A;  3PKC A;  2HOW A;  2GG3 A;  2BH3 A;  5CDE A;  1B6A A;  3IU9 A;  4FLL A;  4RGZ 1;  4FKC A;  1XGM A;  2GG9 A;  2EVC A;  3PN9 A;  1A16 A;  3D27 A;  1YJ3 A;  2BWU A;  1PV9 A;  3I7M A;  5CE6 A;  1C24 A;  1B59 A;  2V3Y A;  1MAT A;  1YW8 A;  4IKS A;  4IU6 A;  4EGE A;  4U6C A;  4QR8 A;  2NQ7 A;  3MAT A;  2Q94 A;  5JFR A;  2ADU A;  4RZZ A;  4B28 A;  1WKM A;  3L7G A;  2P9A A;  1XGN A;  1R5G A;  2Q92 A;  4HXX A;  3PKB A;  4ZNG A;  2G6P A;  3O5V A;  4FLI A;  2V6C A;  3S6B A;  4Z7M A;  2GZ5 A;  3FMQ A;  3OOO A;  2P98 A;  2Q95 A;  3BIQ A;  2OKN A;  2B3H A;  3TB5 A;  5JHU A;  2DFI A;  2GG0 A;  2BHA A;  3CB6 A;  1XGO A;  2GU4 A;  2Q8K A;  1QXY A;  4U6J A;  1WBQ A;  1QXZ A;  3FM3 A;  2EA2 A;  3Q6D A;  1KQ9 A;  1WY2 A;  4A6V A;  4RZY A;  2ZSG A;  4KM3 A;  5CDL A;  3CTZ A;  3RVA A;  3QOC A; 
#chains in the Genus database with same CATH topology
 4OOK A;  5CNX A;  1BN5 A;  5CLS A;  2EVM A;  3TAV A;  3L24 A;  3OVK A;  4IDY A;  2P99 A;  5E2C A;  2GG8 A;  2Q93 A;  4U73 A;  4FLJ A;  1QXW A;  4IKU A;  3PEB A;  4S01 A;  1WLR A;  4A6W A;  1W7V A;  5CIK A;  2NQ6 A;  2IW2 A;  2BWX A;  5CDV A;  2GGC A;  4S2T P;  2Q96 A;  2BHB A;  3IU8 A;  2V3Z A;  4MAT A;  4U6Z A;  1M35 A;  2BWY A;  4IF7 A;  1C23 A;  4IEC A;  4IPA A;  4U76 A;  1C21 A;  2BWV A;  4FO7 A;  4U1B A;  4ZWP A;  2OAZ A;  3PKE A;  2GGB A;  1WN1 A;  2EA4 A;  4ZWU A;  2GG5 A;  4U6E A;  1C27 A;  1N51 A;  5FCF A;  3FMR A;  2GA2 A;  4R60 A;  2BN7 A;  3MX6 A;  4U75 A;  2EVO A;  4PNC A;  2GU5 A;  2B3K A;  4FLK A;  4FO8 A;  1XNZ A;  1CHM A;  2BWW A;  2MAT A;  2V3X A;  4IKR A;  4S2R P;  1YVM A;  3ROR A;  1R5H A;  5JI6 A;  4PV4 A;  3IL0 A;  2GTX A;  2GG2 A;  4U71 A;  2BHC A;  1BOA A;  1YW7 A;  2BB7 A;  5D6E A;  1O0X A;  5E5B A;  3PKD A;  2BWS A;  4U6W A;  5D6F A;  2BHD A;  1JAW A;  2GU6 A;  3BIT A;  1W2M A;  4FUK A;  3CB5 A;  1XGS A;  3IG4 A;  4IKT A;  4U70 A;  4JUQ A;  4ZWO A;  3BIP A;  1C22 A;  2GG7 A;  1R58 A;  2GU7 A;  5FCH A;  1WL6 A;  1WL9 A;  1QZY A;  1YW9 A;  3MR1 A;  1Y1N A;  1KQ0 A;  1KP0 A;  4U69 A;  2B3L A;  3PKA A;  4S00 A;  2BWT A;  3IU7 A;  3PKC A;  2HOW A;  2GG3 A;  2BH3 A;  5CDE A;  1B6A A;  3IU9 A;  4FLL A;  4RGZ 1;  4FKC A;  1XGM A;  2GG9 A;  2EVC A;  3PN9 A;  1A16 A;  3D27 A;  1YJ3 A;  2BWU A;  1PV9 A;  3I7M A;  5CE6 A;  1C24 A;  1B59 A;  2V3Y A;  1MAT A;  1YW8 A;  4IKS A;  4IU6 A;  4EGE A;  4U6C A;  4QR8 A;  2NQ7 A;  3MAT A;  2Q94 A;  5JFR A;  2ADU A;  4RZZ A;  4B28 A;  1WKM A;  3L7G A;  2P9A A;  1XGN A;  1R5G A;  2Q92 A;  4HXX A;  3PKB A;  4ZNG A;  2G6P A;  3O5V A;  4FLI A;  2V6C A;  3S6B A;  4Z7M A;  2GZ5 A;  3FMQ A;  3OOO A;  2P98 A;  2Q95 A;  3BIQ A;  2OKN A;  2B3H A;  3TB5 A;  5JHU A;  2DFI A;  2GG0 A;  2BHA A;  3CB6 A;  1XGO A;  2GU4 A;  2Q8K A;  1QXY A;  4U6J A;  1WBQ A;  1QXZ A;  3FM3 A;  2EA2 A;  3Q6D A;  1KQ9 A;  1WY2 A;  4A6V A;  4RZY A;  2ZSG A;  4KM3 A;  5CDL A;  3CTZ A;  3RVA A;  3QOC A; 
#chains in the Genus database with same CATH homology
 4OOK A;  5CNX A;  1BN5 A;  5CLS A;  2EVM A;  3TAV A;  3L24 A;  3OVK A;  4IDY A;  2P99 A;  5E2C A;  2GG8 A;  2Q93 A;  4U73 A;  4FLJ A;  1QXW A;  4IKU A;  3PEB A;  4S01 A;  1WLR A;  4A6W A;  1W7V A;  5CIK A;  2NQ6 A;  2IW2 A;  2BWX A;  5CDV A;  2GGC A;  4S2T P;  2Q96 A;  2BHB A;  3IU8 A;  2V3Z A;  4MAT A;  4U6Z A;  1M35 A;  2BWY A;  4IF7 A;  1C23 A;  4IEC A;  4IPA A;  4U76 A;  1C21 A;  2BWV A;  4FO7 A;  4U1B A;  4ZWP A;  2OAZ A;  3PKE A;  2GGB A;  1WN1 A;  2EA4 A;  4ZWU A;  2GG5 A;  4U6E A;  1C27 A;  1N51 A;  5FCF A;  3FMR A;  2GA2 A;  4R60 A;  2BN7 A;  3MX6 A;  4U75 A;  2EVO A;  4PNC A;  2GU5 A;  2B3K A;  4FLK A;  4FO8 A;  1XNZ A;  1CHM A;  2BWW A;  2MAT A;  2V3X A;  4IKR A;  4S2R P;  1YVM A;  3ROR A;  1R5H A;  5JI6 A;  4PV4 A;  3IL0 A;  2GTX A;  2GG2 A;  4U71 A;  2BHC A;  1BOA A;  1YW7 A;  2BB7 A;  5D6E A;  1O0X A;  5E5B A;  3PKD A;  2BWS A;  4U6W A;  5D6F A;  2BHD A;  1JAW A;  2GU6 A;  3BIT A;  1W2M A;  4FUK A;  3CB5 A;  1XGS A;  3IG4 A;  4IKT A;  4U70 A;  4JUQ A;  4ZWO A;  3BIP A;  1C22 A;  2GG7 A;  1R58 A;  2GU7 A;  5FCH A;  1WL6 A;  1WL9 A;  1QZY A;  1YW9 A;  3MR1 A;  1Y1N A;  1KQ0 A;  1KP0 A;  4U69 A;  2B3L A;  3PKA A;  4S00 A;  2BWT A;  3IU7 A;  3PKC A;  2HOW A;  2GG3 A;  2BH3 A;  5CDE A;  1B6A A;  3IU9 A;  4FLL A;  4RGZ 1;  4FKC A;  1XGM A;  2GG9 A;  2EVC A;  3PN9 A;  1A16 A;  3D27 A;  1YJ3 A;  2BWU A;  1PV9 A;  3I7M A;  5CE6 A;  1C24 A;  1B59 A;  2V3Y A;  1MAT A;  1YW8 A;  4IKS A;  4IU6 A;  4EGE A;  4U6C A;  4QR8 A;  2NQ7 A;  3MAT A;  2Q94 A;  5JFR A;  2ADU A;  4RZZ A;  4B28 A;  1WKM A;  3L7G A;  2P9A A;  1XGN A;  1R5G A;  2Q92 A;  4HXX A;  3PKB A;  4ZNG A;  2G6P A;  3O5V A;  4FLI A;  2V6C A;  3S6B A;  4Z7M A;  2GZ5 A;  3FMQ A;  3OOO A;  2P98 A;  2Q95 A;  3BIQ A;  2OKN A;  2B3H A;  3TB5 A;  5JHU A;  2DFI A;  2GG0 A;  2BHA A;  3CB6 A;  1XGO A;  2GU4 A;  2Q8K A;  1QXY A;  4U6J A;  1WBQ A;  1QXZ A;  3FM3 A;  2EA2 A;  3Q6D A;  1KQ9 A;  1WY2 A;  4A6V A;  4RZY A;  2ZSG A;  4KM3 A;  5CDL A;  3CTZ A;  3RVA A;  3QOC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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