2OKNA

Crystal strcture of human prolidase
Total Genus 160
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
sequence length
477
structure length
477
Chain Sequence
GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase
molecule keywords Xaa-Pro dipeptidase
publication title Crystal Structure of Human Prolidase: The Molecular Basis of PD Disease.
rcsb
source organism Homo sapiens
total genus 160
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2007-01-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2oknA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2oknA02
4U6ZA 5E5BA 1C24A 2B3KA 4U73A 1R58A 1YJ3A 4FO8A 4FLLA 1W7VA 4KM3A 3RORA 4IKRA 2GGBA 1XNZA 2MATA 2V3XA 4U70A 4U1BA 1WL6A 4ZWOA 2BHDA 1C23A 3QOCA 1B59A 1WKMA 2BHAA 4HXXA 5CE6A 2GU7A 2ADUA 3OVKA 2NQ6A 3OOOA 1WL9A 4MATA 3IG4A 4IPAA 4U6JA 2EA4A 2EVOA 3BITA 4IU6A 4U69A 4U6EA 2BHBA 3O5VA 4IKSA 2GU6A 4S01A 1KQ9A 3PKAA 3BIPA 3PN9A 1WLRA 1WN1A 4U76A 1QXYA 1XGMA 4QR8A 2GG5A 2Q95A 1CHMA 1C27A 2OAZA 5CIKA 3CB6A 1WBQA 2NQ7A 4FLIA 3MX6A 4EGEA 2BWVA 5CDLA 2GA2A 4IDYA 2EA2A 5E2CA 1C21A 4ZWUA 1BOAA 1M35A 4PV4A 3FMQA 2G6PA 2P99A 2BN7A 3I7MA 4FKCA 5FCHA 4S2RP 1PV9A 1O0XA 4Z7MA 1B6AA 4A6WA 2Q8KA 3MR1A 1MATA 5CDEA 2P9AA 4PNCA 2BWTA 3L24A 4U6WA 1Y1NA 2GG7A 2GZ5A 1QZYA 1KP0A 3RVAA 2Q94A 5JI6A 1KQ0A 4S2TP 1QXWA 2GG9A 4FLKA 4IKUA 2V6CA 4RZZA 4R60A 3PKCA 4JUQA 5CLSA 3CTZA 5JHUA 1XGSA 3IU7A 2GG0A 3FMRA 4A6VA 2ZSGA 4U71A 1WY2A 2EVCA 1XGOA 3S6BA 2P98A 1BN5A 4FUKA 3TB5A 3PKEA 1R5GA 1YW9A 1R5HA 5FCFA 3CB5A 1C22A 1YVMA 2B3HA 2BB7A 2EVMA 5D6FA 3PKDA 3L7GA 2BH3A 4OOKA 3FM3A 3IU9A 1YW8A 1W2MA 3Q6DA 4RGZ1 2GG8A 2GGCA 3IU8A 4FO7A 2BWYA 1XGNA 4B28A 3MATA 4IECA 2Q93A 3PEBA 4ZWPA 1JAWA 2OKNA 4S00A 2BHCA 4ZNGA 2B3LA 2GG3A 2GU5A 4IKTA 5CNXA 2Q92A 2BWUA 2V3YA 5CDVA 2Q96A 4U75A 2BWXA 2BWWA 4U6CA 1N51A 3BIQA 2V3ZA 1YW7A 2GG2A 3TAVA 3D27A 1A16A 2BWSA 2DFIA 5JFRA 3IL0A 4RZYA 1QXZA 4FLJA 2HOWA 2IW2A 2GTXA 2GU4A 5D6EA 4IF7A 3PKBA
chains in the Genus database with same CATH superfamily
4U6ZA 5E5BA 1C24A 2B3KA 4U73A 1R58A 1YJ3A 4FO8A 4FLLA 1W7VA 4KM3A 3RORA 4IKRA 2GGBA 1XNZA 2MATA 2V3XA 4U70A 4U1BA 1WL6A 4ZWOA 2BHDA 1C23A 3QOCA 1B59A 1WKMA 2BHAA 4HXXA 5CE6A 2GU7A 2ADUA 3OVKA 2NQ6A 3OOOA 1WL9A 4MATA 3IG4A 4IPAA 4U6JA 2EA4A 2EVOA 3BITA 4IU6A 4U69A 4U6EA 2BHBA 3O5VA 4IKSA 2GU6A 4S01A 1KQ9A 3PKAA 3BIPA 3PN9A 1WLRA 1WN1A 4U76A 1QXYA 1XGMA 4QR8A 2GG5A 2Q95A 1CHMA 1C27A 2OAZA 5CIKA 3CB6A 1WBQA 2NQ7A 4FLIA 3MX6A 4EGEA 2BWVA 5CDLA 2GA2A 4IDYA 2EA2A 5E2CA 1C21A 4ZWUA 1BOAA 1M35A 4PV4A 3FMQA 2G6PA 2P99A 2BN7A 3I7MA 4FKCA 5FCHA 4S2RP 1PV9A 1O0XA 4Z7MA 1B6AA 4A6WA 2Q8KA 3MR1A 1MATA 5CDEA 2P9AA 4PNCA 2BWTA 3L24A 4U6WA 1Y1NA 2GG7A 2GZ5A 1QZYA 1KP0A 3RVAA 2Q94A 5JI6A 1KQ0A 4S2TP 1QXWA 2GG9A 4FLKA 4IKUA 2V6CA 4RZZA 4R60A 3PKCA 4JUQA 5CLSA 3CTZA 5JHUA 1XGSA 3IU7A 2GG0A 3FMRA 4A6VA 2ZSGA 4U71A 1WY2A 2EVCA 1XGOA 3S6BA 2P98A 1BN5A 4FUKA 3TB5A 3PKEA 1R5GA 1YW9A 1R5HA 5FCFA 3CB5A 1C22A 1YVMA 2B3HA 2BB7A 2EVMA 5D6FA 3PKDA 3L7GA 2BH3A 4OOKA 3FM3A 3IU9A 1YW8A 1W2MA 3Q6DA 4RGZ1 2GG8A 2GGCA 3IU8A 4FO7A 2BWYA 1XGNA 4B28A 3MATA 4IECA 2Q93A 3PEBA 4ZWPA 1JAWA 2OKNA 4S00A 2BHCA 4ZNGA 2B3LA 2GG3A 2GU5A 4IKTA 5CNXA 2Q92A 2BWUA 2V3YA 5CDVA 2Q96A 4U75A 2BWXA 2BWWA 4U6CA 1N51A 3BIQA 2V3ZA 1YW7A 2GG2A 3TAVA 3D27A 1A16A 2BWSA 2DFIA 5JFRA 3IL0A 4RZYA 1QXZA 4FLJA 2HOWA 2IW2A 2GTXA 2GU4A 5D6EA 4IF7A 3PKBA
chains in the Genus database with same CATH topology
4U6ZA 5E5BA 1C24A 2B3KA 4U73A 1R58A 1YJ3A 4FO8A 4FLLA 1W7VA 4KM3A 3RORA 4IKRA 2GGBA 1XNZA 2MATA 2V3XA 4U70A 4U1BA 1WL6A 4ZWOA 2BHDA 1C23A 3QOCA 1B59A 1WKMA 2BHAA 4HXXA 5CE6A 2GU7A 2ADUA 3OVKA 2NQ6A 3OOOA 1WL9A 4MATA 3IG4A 4IPAA 4U6JA 2EA4A 2EVOA 3BITA 4IU6A 4U69A 4U6EA 2BHBA 3O5VA 4IKSA 2GU6A 4S01A 1KQ9A 3PKAA 3BIPA 3PN9A 1WLRA 1WN1A 4U76A 1QXYA 1XGMA 4QR8A 2GG5A 2Q95A 1CHMA 1C27A 2OAZA 5CIKA 3CB6A 1WBQA 2NQ7A 4FLIA 3MX6A 4EGEA 2BWVA 5CDLA 2GA2A 4IDYA 2EA2A 5E2CA 1C21A 4ZWUA 1BOAA 1M35A 4PV4A 3FMQA 2G6PA 2P99A 2BN7A 3I7MA 4FKCA 5FCHA 4S2RP 1PV9A 1O0XA 4Z7MA 1B6AA 4A6WA 2Q8KA 3MR1A 1MATA 5CDEA 2P9AA 4PNCA 2BWTA 3L24A 4U6WA 1Y1NA 2GG7A 2GZ5A 1QZYA 1KP0A 3RVAA 2Q94A 5JI6A 1KQ0A 4S2TP 1QXWA 2GG9A 4FLKA 4IKUA 2V6CA 4RZZA 4R60A 3PKCA 4JUQA 5CLSA 3CTZA 5JHUA 1XGSA 3IU7A 2GG0A 3FMRA 4A6VA 2ZSGA 4U71A 1WY2A 2EVCA 1XGOA 3S6BA 2P98A 1BN5A 4FUKA 3TB5A 3PKEA 1R5GA 1YW9A 1R5HA 5FCFA 3CB5A 1C22A 1YVMA 2B3HA 2BB7A 2EVMA 5D6FA 3PKDA 3L7GA 2BH3A 4OOKA 3FM3A 3IU9A 1YW8A 1W2MA 3Q6DA 4RGZ1 2GG8A 2GGCA 3IU8A 4FO7A 2BWYA 1XGNA 4B28A 3MATA 4IECA 2Q93A 3PEBA 4ZWPA 1JAWA 2OKNA 4S00A 2BHCA 4ZNGA 2B3LA 2GG3A 2GU5A 4IKTA 5CNXA 2Q92A 2BWUA 2V3YA 5CDVA 2Q96A 4U75A 2BWXA 2BWWA 4U6CA 1N51A 3BIQA 2V3ZA 1YW7A 2GG2A 3TAVA 3D27A 1A16A 2BWSA 2DFIA 5JFRA 3IL0A 4RZYA 1QXZA 4FLJA 2HOWA 2IW2A 2GTXA 2GU4A 5D6EA 4IF7A 3PKBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U6Z A;  5E5B A;  1C24 A;  2B3K A;  4U73 A;  1R58 A;  1YJ3 A;  4FO8 A;  4FLL A;  1W7V A;  4KM3 A;  3ROR A;  4IKR A;  2GGB A;  1XNZ A;  2MAT A;  2V3X A;  4U70 A;  4U1B A;  1WL6 A;  4ZWO A;  2BHD A;  1C23 A;  3QOC A;  1B59 A;  1WKM A;  2BHA A;  4HXX A;  5CE6 A;  2GU7 A;  2ADU A;  3OVK A;  2NQ6 A;  3OOO A;  1WL9 A;  4MAT A;  3IG4 A;  4IPA A;  4U6J A;  2EA4 A;  2EVO A;  3BIT A;  4IU6 A;  4U69 A;  4U6E A;  2BHB A;  3O5V A;  4IKS A;  2GU6 A;  4S01 A;  1KQ9 A;  3PKA A;  3BIP A;  3PN9 A;  1WLR A;  1WN1 A;  4U76 A;  1QXY A;  1XGM A;  4QR8 A;  2GG5 A;  2Q95 A;  1CHM A;  1C27 A;  2OAZ A;  5CIK A;  3CB6 A;  1WBQ A;  2NQ7 A;  4FLI A;  3MX6 A;  4EGE A;  2BWV A;  5CDL A;  2GA2 A;  4IDY A;  2EA2 A;  5E2C A;  1C21 A;  4ZWU A;  1BOA A;  1M35 A;  4PV4 A;  3FMQ A;  2G6P A;  2P99 A;  2BN7 A;  3I7M A;  4FKC A;  5FCH A;  4S2R P;  1PV9 A;  1O0X A;  4Z7M A;  1B6A A;  4A6W A;  2Q8K A;  3MR1 A;  1MAT A;  5CDE A;  2P9A A;  4PNC A;  2BWT A;  3L24 A;  4U6W A;  1Y1N A;  2GG7 A;  2GZ5 A;  1QZY A;  1KP0 A;  3RVA A;  2Q94 A;  5JI6 A;  1KQ0 A;  4S2T P;  1QXW A;  2GG9 A;  4FLK A;  4IKU A;  2V6C A;  4RZZ A;  4R60 A;  3PKC A;  4JUQ A;  5CLS A;  3CTZ A;  5JHU A;  1XGS A;  3IU7 A;  2GG0 A;  3FMR A;  4A6V A;  2ZSG A;  4U71 A;  1WY2 A;  2EVC A;  1XGO A;  3S6B A;  2P98 A;  1BN5 A;  4FUK A;  3TB5 A;  3PKE A;  1R5G A;  1YW9 A;  1R5H A;  5FCF A;  3CB5 A;  1C22 A;  1YVM A;  2B3H A;  2BB7 A;  2EVM A;  5D6F A;  3PKD A;  3L7G A;  2BH3 A;  4OOK A;  3FM3 A;  3IU9 A;  1YW8 A;  1W2M A;  3Q6D A;  4RGZ 1;  2GG8 A;  2GGC A;  3IU8 A;  4FO7 A;  2BWY A;  1XGN A;  4B28 A;  3MAT A;  4IEC A;  2Q93 A;  3PEB A;  4ZWP A;  1JAW A;  2OKN A;  4S00 A;  2BHC A;  4ZNG A;  2B3L A;  2GG3 A;  2GU5 A;  4IKT A;  5CNX A;  2Q92 A;  2BWU A;  2V3Y A;  5CDV A;  2Q96 A;  4U75 A;  2BWX A;  2BWW A;  4U6C A;  1N51 A;  3BIQ A;  2V3Z A;  1YW7 A;  2GG2 A;  3TAV A;  3D27 A;  1A16 A;  2BWS A;  2DFI A;  5JFR A;  3IL0 A;  4RZY A;  1QXZ A;  4FLJ A;  2HOW A;  2IW2 A;  2GTX A;  2GU4 A;  5D6E A;  4IF7 A;  3PKB A; 
#chains in the Genus database with same CATH topology
 4U6Z A;  5E5B A;  1C24 A;  2B3K A;  4U73 A;  1R58 A;  1YJ3 A;  4FO8 A;  4FLL A;  1W7V A;  4KM3 A;  3ROR A;  4IKR A;  2GGB A;  1XNZ A;  2MAT A;  2V3X A;  4U70 A;  4U1B A;  1WL6 A;  4ZWO A;  2BHD A;  1C23 A;  3QOC A;  1B59 A;  1WKM A;  2BHA A;  4HXX A;  5CE6 A;  2GU7 A;  2ADU A;  3OVK A;  2NQ6 A;  3OOO A;  1WL9 A;  4MAT A;  3IG4 A;  4IPA A;  4U6J A;  2EA4 A;  2EVO A;  3BIT A;  4IU6 A;  4U69 A;  4U6E A;  2BHB A;  3O5V A;  4IKS A;  2GU6 A;  4S01 A;  1KQ9 A;  3PKA A;  3BIP A;  3PN9 A;  1WLR A;  1WN1 A;  4U76 A;  1QXY A;  1XGM A;  4QR8 A;  2GG5 A;  2Q95 A;  1CHM A;  1C27 A;  2OAZ A;  5CIK A;  3CB6 A;  1WBQ A;  2NQ7 A;  4FLI A;  3MX6 A;  4EGE A;  2BWV A;  5CDL A;  2GA2 A;  4IDY A;  2EA2 A;  5E2C A;  1C21 A;  4ZWU A;  1BOA A;  1M35 A;  4PV4 A;  3FMQ A;  2G6P A;  2P99 A;  2BN7 A;  3I7M A;  4FKC A;  5FCH A;  4S2R P;  1PV9 A;  1O0X A;  4Z7M A;  1B6A A;  4A6W A;  2Q8K A;  3MR1 A;  1MAT A;  5CDE A;  2P9A A;  4PNC A;  2BWT A;  3L24 A;  4U6W A;  1Y1N A;  2GG7 A;  2GZ5 A;  1QZY A;  1KP0 A;  3RVA A;  2Q94 A;  5JI6 A;  1KQ0 A;  4S2T P;  1QXW A;  2GG9 A;  4FLK A;  4IKU A;  2V6C A;  4RZZ A;  4R60 A;  3PKC A;  4JUQ A;  5CLS A;  3CTZ A;  5JHU A;  1XGS A;  3IU7 A;  2GG0 A;  3FMR A;  4A6V A;  2ZSG A;  4U71 A;  1WY2 A;  2EVC A;  1XGO A;  3S6B A;  2P98 A;  1BN5 A;  4FUK A;  3TB5 A;  3PKE A;  1R5G A;  1YW9 A;  1R5H A;  5FCF A;  3CB5 A;  1C22 A;  1YVM A;  2B3H A;  2BB7 A;  2EVM A;  5D6F A;  3PKD A;  3L7G A;  2BH3 A;  4OOK A;  3FM3 A;  3IU9 A;  1YW8 A;  1W2M A;  3Q6D A;  4RGZ 1;  2GG8 A;  2GGC A;  3IU8 A;  4FO7 A;  2BWY A;  1XGN A;  4B28 A;  3MAT A;  4IEC A;  2Q93 A;  3PEB A;  4ZWP A;  1JAW A;  2OKN A;  4S00 A;  2BHC A;  4ZNG A;  2B3L A;  2GG3 A;  2GU5 A;  4IKT A;  5CNX A;  2Q92 A;  2BWU A;  2V3Y A;  5CDV A;  2Q96 A;  4U75 A;  2BWX A;  2BWW A;  4U6C A;  1N51 A;  3BIQ A;  2V3Z A;  1YW7 A;  2GG2 A;  3TAV A;  3D27 A;  1A16 A;  2BWS A;  2DFI A;  5JFR A;  3IL0 A;  4RZY A;  1QXZ A;  4FLJ A;  2HOW A;  2IW2 A;  2GTX A;  2GU4 A;  5D6E A;  4IF7 A;  3PKB A; 
#chains in the Genus database with same CATH homology
 4U6Z A;  5E5B A;  1C24 A;  2B3K A;  4U73 A;  1R58 A;  1YJ3 A;  4FO8 A;  4FLL A;  1W7V A;  4KM3 A;  3ROR A;  4IKR A;  2GGB A;  1XNZ A;  2MAT A;  2V3X A;  4U70 A;  4U1B A;  1WL6 A;  4ZWO A;  2BHD A;  1C23 A;  3QOC A;  1B59 A;  1WKM A;  2BHA A;  4HXX A;  5CE6 A;  2GU7 A;  2ADU A;  3OVK A;  2NQ6 A;  3OOO A;  1WL9 A;  4MAT A;  3IG4 A;  4IPA A;  4U6J A;  2EA4 A;  2EVO A;  3BIT A;  4IU6 A;  4U69 A;  4U6E A;  2BHB A;  3O5V A;  4IKS A;  2GU6 A;  4S01 A;  1KQ9 A;  3PKA A;  3BIP A;  3PN9 A;  1WLR A;  1WN1 A;  4U76 A;  1QXY A;  1XGM A;  4QR8 A;  2GG5 A;  2Q95 A;  1CHM A;  1C27 A;  2OAZ A;  5CIK A;  3CB6 A;  1WBQ A;  2NQ7 A;  4FLI A;  3MX6 A;  4EGE A;  2BWV A;  5CDL A;  2GA2 A;  4IDY A;  2EA2 A;  5E2C A;  1C21 A;  4ZWU A;  1BOA A;  1M35 A;  4PV4 A;  3FMQ A;  2G6P A;  2P99 A;  2BN7 A;  3I7M A;  4FKC A;  5FCH A;  4S2R P;  1PV9 A;  1O0X A;  4Z7M A;  1B6A A;  4A6W A;  2Q8K A;  3MR1 A;  1MAT A;  5CDE A;  2P9A A;  4PNC A;  2BWT A;  3L24 A;  4U6W A;  1Y1N A;  2GG7 A;  2GZ5 A;  1QZY A;  1KP0 A;  3RVA A;  2Q94 A;  5JI6 A;  1KQ0 A;  4S2T P;  1QXW A;  2GG9 A;  4FLK A;  4IKU A;  2V6C A;  4RZZ A;  4R60 A;  3PKC A;  4JUQ A;  5CLS A;  3CTZ A;  5JHU A;  1XGS A;  3IU7 A;  2GG0 A;  3FMR A;  4A6V A;  2ZSG A;  4U71 A;  1WY2 A;  2EVC A;  1XGO A;  3S6B A;  2P98 A;  1BN5 A;  4FUK A;  3TB5 A;  3PKE A;  1R5G A;  1YW9 A;  1R5H A;  5FCF A;  3CB5 A;  1C22 A;  1YVM A;  2B3H A;  2BB7 A;  2EVM A;  5D6F A;  3PKD A;  3L7G A;  2BH3 A;  4OOK A;  3FM3 A;  3IU9 A;  1YW8 A;  1W2M A;  3Q6D A;  4RGZ 1;  2GG8 A;  2GGC A;  3IU8 A;  4FO7 A;  2BWY A;  1XGN A;  4B28 A;  3MAT A;  4IEC A;  2Q93 A;  3PEB A;  4ZWP A;  1JAW A;  2OKN A;  4S00 A;  2BHC A;  4ZNG A;  2B3L A;  2GG3 A;  2GU5 A;  4IKT A;  5CNX A;  2Q92 A;  2BWU A;  2V3Y A;  5CDV A;  2Q96 A;  4U75 A;  2BWX A;  2BWW A;  4U6C A;  1N51 A;  3BIQ A;  2V3Z A;  1YW7 A;  2GG2 A;  3TAV A;  3D27 A;  1A16 A;  2BWS A;  2DFI A;  5JFR A;  3IL0 A;  4RZY A;  1QXZ A;  4FLJ A;  2HOW A;  2IW2 A;  2GTX A;  2GU4 A;  5D6E A;  4IF7 A;  3PKB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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