2OKNA

Crystal strcture of human prolidase
Total Genus 160
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
160
sequence length
477
structure length
477
Chain Sequence
b'GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVMKAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDHLLDEALADPARASFFNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGC'
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Xaa-Pro dipeptidase
publication title Crystal Structure of Human Prolidase: The Molecular Basis of PD Disease.
rcsb
source organism Homo sapiens
molecule tags Hydrolase
total genus 160
structure length 477
sequence length 477
chains with identical sequence B
ec nomenclature ec 3.4.13.9: Xaa-Pro dipeptidase.
pdb deposition date 2007-01-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
A PF05195 AMP_N Aminopeptidase P, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.350.10 Alpha Beta 3-Layer(aba) Sandwich Creatine Amidinohydrolase; Chain A, domain 1 Creatinase/prolidase N-terminal domain 2oknA01
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2oknA02
4RZYA 1R58A 3FMQA 2Q93A 1R5HA 2GGCA 3IU7A 1QXYA 1WY2A 2GU5A 5CLSA 4IECA 3MX6A 5CE6A 1JAWA 3FMRA 1KP0A 4U6WA 4JUQA 3D27A 4FUKA 1W2MA 4IKTA 4PV4A 4IKUA 3BIPA 3BIQA 2Q96A 3PKBA 3IG4A 5FCHA 1A16A 4S2TP 5CNXA 3L24A 1C24A 4QR8A 2EVMA 4FKCA 2GU7A 4A6VA 2BHCA 2P99A 2GG0A 5CDVA 2GG9A 3PKEA 4U73A 1QXZA 2EA4A 4U75A 2B3KA 4FLIA 4U69A 3S6BA 5JI6A 3TAVA 3RVAA 5CDLA 2V6CA 1YJ3A 4PNCA 5JFRA 5FCFA 4B28A 2G6PA 2Q92A 3IL0A 2BWYA 2BWXA 3O5VA 2Q8KA 1BOAA 1C22A 1KQ9A 2DFIA 2BHBA 2BWUA 4A6WA 4Z7MA 5CIKA 1QZYA 4IU6A 4IPAA 3CB5A 2NQ6A 1YW9A 2OAZA 1B59A 2BHAA 1M35A 2P98A 3PKCA 4U70A 5JHUA 4FLLA 3Q6DA 3OVKA 1MATA 2NQ7A 4S2RP 3PKAA 1PV9A 3BITA 1WL9A 2GU6A 3TB5A 4U76A 2GG7A 2EVCA 3PN9A 1YVMA 4OOKA 4ZWUA 1O0XA 5CDEA 1WL6A 1Y1NA 4IKSA 1B6AA 2HOWA 1C23A 2BB7A 5E2CA 1XGOA 3PKDA 1XGNA 2B3HA 2P9AA 4MATA 4RZZA 2BH3A 2V3XA 1XGMA 2BWVA 1QXWA 4IF7A 4U6CA 4U6JA 1CHMA 1WKMA 2Q95A 4U71A 1XNZA 4S01A 2V3YA 2B3LA 2MATA 1YW7A 2ADUA 2GA2A 2GGBA 5D6EA 2Q94A 4U1BA 2GG5A 2ZSGA 2GTXA 3QOCA 1YW8A 3MATA 4KM3A 1WN1A 2BHDA 4IKRA 3MR1A 2GZ5A 3CB6A 4IDYA 1C27A 2GG2A 2GG3A 1WBQA 4HXXA 2GG8A 1KQ0A 1W7VA 4FLKA 4ZNGA 4S00A 3IU8A 2BWWA 4EGEA 1XGSA 3FM3A 3OOOA 4U6EA 3PEBA 2EA2A 2GU4A 4FLJA 2IW2A 4RGZ1 1R5GA 2BN7A 4U6ZA 4FO8A 3L7GA 3IU9A 4ZWPA 1C21A 2V3ZA 3RORA 3I7MA 2EVOA 2OKNA 5D6FA 1BN5A 3CTZA 5E5BA 4R60A 1N51A 1WLRA 4FO7A 4ZWOA 2BWTA 2BWSA
chains in the Genus database with same CATH superfamily
4RZYA 1R58A 3FMQA 2Q93A 1R5HA 2GGCA 3IU7A 1QXYA 1WY2A 2GU5A 5CLSA 4IECA 3MX6A 5CE6A 1JAWA 3FMRA 1KP0A 4U6WA 4JUQA 3D27A 4FUKA 1W2MA 4IKTA 4PV4A 4IKUA 3BIPA 3BIQA 2Q96A 3PKBA 3IG4A 5FCHA 1A16A 4S2TP 5CNXA 3L24A 1C24A 4QR8A 2EVMA 4FKCA 2GU7A 4A6VA 2BHCA 2P99A 2GG0A 5CDVA 2GG9A 3PKEA 4U73A 1QXZA 2EA4A 4U75A 2B3KA 4FLIA 4U69A 3S6BA 5JI6A 3TAVA 3RVAA 5CDLA 2V6CA 1YJ3A 4PNCA 5JFRA 5FCFA 4B28A 2G6PA 2Q92A 3IL0A 2BWYA 2BWXA 3O5VA 2Q8KA 1BOAA 1C22A 1KQ9A 2DFIA 2BHBA 2BWUA 4A6WA 4Z7MA 5CIKA 1QZYA 4IU6A 4IPAA 3CB5A 2NQ6A 1YW9A 2OAZA 1B59A 2BHAA 1M35A 2P98A 3PKCA 4U70A 5JHUA 4FLLA 3Q6DA 3OVKA 1MATA 2NQ7A 4S2RP 3PKAA 1PV9A 3BITA 1WL9A 2GU6A 3TB5A 4U76A 2GG7A 2EVCA 3PN9A 1YVMA 4OOKA 4ZWUA 1O0XA 5CDEA 1WL6A 1Y1NA 4IKSA 1B6AA 2HOWA 1C23A 2BB7A 5E2CA 1XGOA 3PKDA 1XGNA 2B3HA 2P9AA 4MATA 4RZZA 2BH3A 2V3XA 1XGMA 2BWVA 1QXWA 4IF7A 4U6CA 4U6JA 1CHMA 1WKMA 2Q95A 4U71A 1XNZA 4S01A 2V3YA 2B3LA 2MATA 1YW7A 2ADUA 2GA2A 2GGBA 5D6EA 2Q94A 4U1BA 2GG5A 2ZSGA 2GTXA 3QOCA 1YW8A 3MATA 4KM3A 1WN1A 2BHDA 4IKRA 3MR1A 2GZ5A 3CB6A 4IDYA 1C27A 2GG2A 2GG3A 1WBQA 4HXXA 2GG8A 1KQ0A 1W7VA 4FLKA 4ZNGA 4S00A 3IU8A 2BWWA 4EGEA 1XGSA 3FM3A 3OOOA 4U6EA 3PEBA 2EA2A 2GU4A 4FLJA 2IW2A 4RGZ1 1R5GA 2BN7A 4U6ZA 4FO8A 3L7GA 3IU9A 4ZWPA 1C21A 2V3ZA 3RORA 3I7MA 2EVOA 2OKNA 5D6FA 1BN5A 3CTZA 5E5BA 4R60A 1N51A 1WLRA 4FO7A 4ZWOA 2BWTA 2BWSA
chains in the Genus database with same CATH topology
4RZYA 1R58A 3FMQA 2Q93A 1R5HA 2GGCA 3IU7A 1QXYA 1WY2A 2GU5A 5CLSA 4IECA 3MX6A 5CE6A 1JAWA 3FMRA 1KP0A 4U6WA 4JUQA 3D27A 4FUKA 1W2MA 4IKTA 4PV4A 4IKUA 3BIPA 3BIQA 2Q96A 3PKBA 3IG4A 5FCHA 1A16A 4S2TP 5CNXA 3L24A 1C24A 4QR8A 2EVMA 4FKCA 2GU7A 4A6VA 2BHCA 2P99A 2GG0A 5CDVA 2GG9A 3PKEA 4U73A 1QXZA 2EA4A 4U75A 2B3KA 4FLIA 4U69A 3S6BA 5JI6A 3TAVA 3RVAA 5CDLA 2V6CA 1YJ3A 4PNCA 5JFRA 5FCFA 4B28A 2G6PA 2Q92A 3IL0A 2BWYA 2BWXA 3O5VA 2Q8KA 1BOAA 1C22A 1KQ9A 2DFIA 2BHBA 2BWUA 4A6WA 4Z7MA 5CIKA 1QZYA 4IU6A 4IPAA 3CB5A 2NQ6A 1YW9A 2OAZA 1B59A 2BHAA 1M35A 2P98A 3PKCA 4U70A 5JHUA 4FLLA 3Q6DA 3OVKA 1MATA 2NQ7A 4S2RP 3PKAA 1PV9A 3BITA 1WL9A 2GU6A 3TB5A 4U76A 2GG7A 2EVCA 3PN9A 1YVMA 4OOKA 4ZWUA 1O0XA 5CDEA 1WL6A 1Y1NA 4IKSA 1B6AA 2HOWA 1C23A 2BB7A 5E2CA 1XGOA 3PKDA 1XGNA 2B3HA 2P9AA 4MATA 4RZZA 2BH3A 2V3XA 1XGMA 2BWVA 1QXWA 4IF7A 4U6CA 4U6JA 1CHMA 1WKMA 2Q95A 4U71A 1XNZA 4S01A 2V3YA 2B3LA 2MATA 1YW7A 2ADUA 2GA2A 2GGBA 5D6EA 2Q94A 4U1BA 2GG5A 2ZSGA 2GTXA 3QOCA 1YW8A 3MATA 4KM3A 1WN1A 2BHDA 4IKRA 3MR1A 2GZ5A 3CB6A 4IDYA 1C27A 2GG2A 2GG3A 1WBQA 4HXXA 2GG8A 1KQ0A 1W7VA 4FLKA 4ZNGA 4S00A 3IU8A 2BWWA 4EGEA 1XGSA 3FM3A 3OOOA 4U6EA 3PEBA 2EA2A 2GU4A 4FLJA 2IW2A 4RGZ1 1R5GA 2BN7A 4U6ZA 4FO8A 3L7GA 3IU9A 4ZWPA 1C21A 2V3ZA 3RORA 3I7MA 2EVOA 2OKNA 5D6FA 1BN5A 3CTZA 5E5BA 4R60A 1N51A 1WLRA 4FO7A 4ZWOA 2BWTA 2BWSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4RZY A;  1R58 A;  3FMQ A;  2Q93 A;  1R5H A;  2GGC A;  3IU7 A;  1QXY A;  1WY2 A;  2GU5 A;  5CLS A;  4IEC A;  3MX6 A;  5CE6 A;  1JAW A;  3FMR A;  1KP0 A;  4U6W A;  4JUQ A;  3D27 A;  4FUK A;  1W2M A;  4IKT A;  4PV4 A;  4IKU A;  3BIP A;  3BIQ A;  2Q96 A;  3PKB A;  3IG4 A;  5FCH A;  1A16 A;  4S2T P;  5CNX A;  3L24 A;  1C24 A;  4QR8 A;  2EVM A;  4FKC A;  2GU7 A;  4A6V A;  2BHC A;  2P99 A;  2GG0 A;  5CDV A;  2GG9 A;  3PKE A;  4U73 A;  1QXZ A;  2EA4 A;  4U75 A;  2B3K A;  4FLI A;  4U69 A;  3S6B A;  5JI6 A;  3TAV A;  3RVA A;  5CDL A;  2V6C A;  1YJ3 A;  4PNC A;  5JFR A;  5FCF A;  4B28 A;  2G6P A;  2Q92 A;  3IL0 A;  2BWY A;  2BWX A;  3O5V A;  2Q8K A;  1BOA A;  1C22 A;  1KQ9 A;  2DFI A;  2BHB A;  2BWU A;  4A6W A;  4Z7M A;  5CIK A;  1QZY A;  4IU6 A;  4IPA A;  3CB5 A;  2NQ6 A;  1YW9 A;  2OAZ A;  1B59 A;  2BHA A;  1M35 A;  2P98 A;  3PKC A;  4U70 A;  5JHU A;  4FLL A;  3Q6D A;  3OVK A;  1MAT A;  2NQ7 A;  4S2R P;  3PKA A;  1PV9 A;  3BIT A;  1WL9 A;  2GU6 A;  3TB5 A;  4U76 A;  2GG7 A;  2EVC A;  3PN9 A;  1YVM A;  4OOK A;  4ZWU A;  1O0X A;  5CDE A;  1WL6 A;  1Y1N A;  4IKS A;  1B6A A;  2HOW A;  1C23 A;  2BB7 A;  5E2C A;  1XGO A;  3PKD A;  1XGN A;  2B3H A;  2P9A A;  4MAT A;  4RZZ A;  2BH3 A;  2V3X A;  1XGM A;  2BWV A;  1QXW A;  4IF7 A;  4U6C A;  4U6J A;  1CHM A;  1WKM A;  2Q95 A;  4U71 A;  1XNZ A;  4S01 A;  2V3Y A;  2B3L A;  2MAT A;  1YW7 A;  2ADU A;  2GA2 A;  2GGB A;  5D6E A;  2Q94 A;  4U1B A;  2GG5 A;  2ZSG A;  2GTX A;  3QOC A;  1YW8 A;  3MAT A;  4KM3 A;  1WN1 A;  2BHD A;  4IKR A;  3MR1 A;  2GZ5 A;  3CB6 A;  4IDY A;  1C27 A;  2GG2 A;  2GG3 A;  1WBQ A;  4HXX A;  2GG8 A;  1KQ0 A;  1W7V A;  4FLK A;  4ZNG A;  4S00 A;  3IU8 A;  2BWW A;  4EGE A;  1XGS A;  3FM3 A;  3OOO A;  4U6E A;  3PEB A;  2EA2 A;  2GU4 A;  4FLJ A;  2IW2 A;  4RGZ 1;  1R5G A;  2BN7 A;  4U6Z A;  4FO8 A;  3L7G A;  3IU9 A;  4ZWP A;  1C21 A;  2V3Z A;  3ROR A;  3I7M A;  2EVO A;  2OKN A;  5D6F A;  1BN5 A;  3CTZ A;  5E5B A;  4R60 A;  1N51 A;  1WLR A;  4FO7 A;  4ZWO A;  2BWT A;  2BWS A; 
#chains in the Genus database with same CATH topology
 4RZY A;  1R58 A;  3FMQ A;  2Q93 A;  1R5H A;  2GGC A;  3IU7 A;  1QXY A;  1WY2 A;  2GU5 A;  5CLS A;  4IEC A;  3MX6 A;  5CE6 A;  1JAW A;  3FMR A;  1KP0 A;  4U6W A;  4JUQ A;  3D27 A;  4FUK A;  1W2M A;  4IKT A;  4PV4 A;  4IKU A;  3BIP A;  3BIQ A;  2Q96 A;  3PKB A;  3IG4 A;  5FCH A;  1A16 A;  4S2T P;  5CNX A;  3L24 A;  1C24 A;  4QR8 A;  2EVM A;  4FKC A;  2GU7 A;  4A6V A;  2BHC A;  2P99 A;  2GG0 A;  5CDV A;  2GG9 A;  3PKE A;  4U73 A;  1QXZ A;  2EA4 A;  4U75 A;  2B3K A;  4FLI A;  4U69 A;  3S6B A;  5JI6 A;  3TAV A;  3RVA A;  5CDL A;  2V6C A;  1YJ3 A;  4PNC A;  5JFR A;  5FCF A;  4B28 A;  2G6P A;  2Q92 A;  3IL0 A;  2BWY A;  2BWX A;  3O5V A;  2Q8K A;  1BOA A;  1C22 A;  1KQ9 A;  2DFI A;  2BHB A;  2BWU A;  4A6W A;  4Z7M A;  5CIK A;  1QZY A;  4IU6 A;  4IPA A;  3CB5 A;  2NQ6 A;  1YW9 A;  2OAZ A;  1B59 A;  2BHA A;  1M35 A;  2P98 A;  3PKC A;  4U70 A;  5JHU A;  4FLL A;  3Q6D A;  3OVK A;  1MAT A;  2NQ7 A;  4S2R P;  3PKA A;  1PV9 A;  3BIT A;  1WL9 A;  2GU6 A;  3TB5 A;  4U76 A;  2GG7 A;  2EVC A;  3PN9 A;  1YVM A;  4OOK A;  4ZWU A;  1O0X A;  5CDE A;  1WL6 A;  1Y1N A;  4IKS A;  1B6A A;  2HOW A;  1C23 A;  2BB7 A;  5E2C A;  1XGO A;  3PKD A;  1XGN A;  2B3H A;  2P9A A;  4MAT A;  4RZZ A;  2BH3 A;  2V3X A;  1XGM A;  2BWV A;  1QXW A;  4IF7 A;  4U6C A;  4U6J A;  1CHM A;  1WKM A;  2Q95 A;  4U71 A;  1XNZ A;  4S01 A;  2V3Y A;  2B3L A;  2MAT A;  1YW7 A;  2ADU A;  2GA2 A;  2GGB A;  5D6E A;  2Q94 A;  4U1B A;  2GG5 A;  2ZSG A;  2GTX A;  3QOC A;  1YW8 A;  3MAT A;  4KM3 A;  1WN1 A;  2BHD A;  4IKR A;  3MR1 A;  2GZ5 A;  3CB6 A;  4IDY A;  1C27 A;  2GG2 A;  2GG3 A;  1WBQ A;  4HXX A;  2GG8 A;  1KQ0 A;  1W7V A;  4FLK A;  4ZNG A;  4S00 A;  3IU8 A;  2BWW A;  4EGE A;  1XGS A;  3FM3 A;  3OOO A;  4U6E A;  3PEB A;  2EA2 A;  2GU4 A;  4FLJ A;  2IW2 A;  4RGZ 1;  1R5G A;  2BN7 A;  4U6Z A;  4FO8 A;  3L7G A;  3IU9 A;  4ZWP A;  1C21 A;  2V3Z A;  3ROR A;  3I7M A;  2EVO A;  2OKN A;  5D6F A;  1BN5 A;  3CTZ A;  5E5B A;  4R60 A;  1N51 A;  1WLR A;  4FO7 A;  4ZWO A;  2BWT A;  2BWS A; 
#chains in the Genus database with same CATH homology
 4RZY A;  1R58 A;  3FMQ A;  2Q93 A;  1R5H A;  2GGC A;  3IU7 A;  1QXY A;  1WY2 A;  2GU5 A;  5CLS A;  4IEC A;  3MX6 A;  5CE6 A;  1JAW A;  3FMR A;  1KP0 A;  4U6W A;  4JUQ A;  3D27 A;  4FUK A;  1W2M A;  4IKT A;  4PV4 A;  4IKU A;  3BIP A;  3BIQ A;  2Q96 A;  3PKB A;  3IG4 A;  5FCH A;  1A16 A;  4S2T P;  5CNX A;  3L24 A;  1C24 A;  4QR8 A;  2EVM A;  4FKC A;  2GU7 A;  4A6V A;  2BHC A;  2P99 A;  2GG0 A;  5CDV A;  2GG9 A;  3PKE A;  4U73 A;  1QXZ A;  2EA4 A;  4U75 A;  2B3K A;  4FLI A;  4U69 A;  3S6B A;  5JI6 A;  3TAV A;  3RVA A;  5CDL A;  2V6C A;  1YJ3 A;  4PNC A;  5JFR A;  5FCF A;  4B28 A;  2G6P A;  2Q92 A;  3IL0 A;  2BWY A;  2BWX A;  3O5V A;  2Q8K A;  1BOA A;  1C22 A;  1KQ9 A;  2DFI A;  2BHB A;  2BWU A;  4A6W A;  4Z7M A;  5CIK A;  1QZY A;  4IU6 A;  4IPA A;  3CB5 A;  2NQ6 A;  1YW9 A;  2OAZ A;  1B59 A;  2BHA A;  1M35 A;  2P98 A;  3PKC A;  4U70 A;  5JHU A;  4FLL A;  3Q6D A;  3OVK A;  1MAT A;  2NQ7 A;  4S2R P;  3PKA A;  1PV9 A;  3BIT A;  1WL9 A;  2GU6 A;  3TB5 A;  4U76 A;  2GG7 A;  2EVC A;  3PN9 A;  1YVM A;  4OOK A;  4ZWU A;  1O0X A;  5CDE A;  1WL6 A;  1Y1N A;  4IKS A;  1B6A A;  2HOW A;  1C23 A;  2BB7 A;  5E2C A;  1XGO A;  3PKD A;  1XGN A;  2B3H A;  2P9A A;  4MAT A;  4RZZ A;  2BH3 A;  2V3X A;  1XGM A;  2BWV A;  1QXW A;  4IF7 A;  4U6C A;  4U6J A;  1CHM A;  1WKM A;  2Q95 A;  4U71 A;  1XNZ A;  4S01 A;  2V3Y A;  2B3L A;  2MAT A;  1YW7 A;  2ADU A;  2GA2 A;  2GGB A;  5D6E A;  2Q94 A;  4U1B A;  2GG5 A;  2ZSG A;  2GTX A;  3QOC A;  1YW8 A;  3MAT A;  4KM3 A;  1WN1 A;  2BHD A;  4IKR A;  3MR1 A;  2GZ5 A;  3CB6 A;  4IDY A;  1C27 A;  2GG2 A;  2GG3 A;  1WBQ A;  4HXX A;  2GG8 A;  1KQ0 A;  1W7V A;  4FLK A;  4ZNG A;  4S00 A;  3IU8 A;  2BWW A;  4EGE A;  1XGS A;  3FM3 A;  3OOO A;  4U6E A;  3PEB A;  2EA2 A;  2GU4 A;  4FLJ A;  2IW2 A;  4RGZ 1;  1R5G A;  2BN7 A;  4U6Z A;  4FO8 A;  3L7G A;  3IU9 A;  4ZWP A;  1C21 A;  2V3Z A;  3ROR A;  3I7M A;  2EVO A;  2OKN A;  5D6F A;  1BN5 A;  3CTZ A;  5E5B A;  4R60 A;  1N51 A;  1WLR A;  4FO7 A;  4ZWO A;  2BWT A;  2BWS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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