2P99A

E. coli methionine aminopeptidase monometalated with inhibitor ye6
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
261
structure length
261
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli
publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 85
structure length 261
sequence length 261
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p99A00
2BH3A 4IF7A 2V6CA 3TAVA 2V3XA 1KQ0A 1WBQA 3PKBA 4U70A 1XNZA 3FM3A 3MX6A 1KQ9A 5FCFA 4U75A 4S01A 4S00A 4FO8A 4U71A 5CDVA 2B3KA 5CDEA 2IW2A 4QR8A 4JUQA 2BB7A 1W7VA 2BN7A 1N51A 4U6EA 1C24A 2Q93A 4U6CA 4U73A 2BWXA 4FLKA 3BIQA 4KM3A 2GZ5A 1KP0A 4U69A 1Y1NA 2BWTA 4Z7MA 2BWWA 2BWYA 1XGOA 1M35A 2V3ZA 3BIPA 3D27A 4RZZA 5CDLA 2NQ7A 3RORA 5JI6A 1BN5A 4HXXA 2BHAA 4S2RP 3CTZA 4S2TP 5JHUA 2EVCA 2B3LA 2GTXA 3PKAA 1WY2A 5D6EA 1BOAA 2GGBA 2OAZA 4FLIA 5D6FA 2Q94A 2GU6A 2P9AA 3MATA 5CLSA 2V3YA 2GG9A 4U6WA 3L7GA 3TB5A 4MATA 3PKEA 2GGCA 3IG4A 1QXYA 1R5GA 1QZYA 2BWVA 1WKMA 1WN1A 2EVMA 2GA2A 3PKCA 5CIKA 3RVAA 2GG5A 4IU6A 1XGSA 4RZYA 5CE6A 1WL6A 1XGMA 2GU4A 5CNXA 4ZWUA 1JAWA 1PV9A 3S6BA 2Q8KA 2Q92A 4OOKA 1MATA 1YJ3A 1B59A 2HOWA 2Q95A 4U6ZA 4B28A 4IPAA 5FCHA 4IKTA 2G6PA 3MR1A 4FLLA 4FO7A 1C23A 4FUKA 4ZWOA 4U76A 1YW7A 3PKDA 4FLJA 2OKNA 3IU9A 3L24A 2BWSA 2GG2A 4IKRA 4PNCA 1YW9A 4ZNGA 1W2MA 1WLRA 2DFIA 4IKUA 4R60A 3CB6A 1YW8A 2GU7A 2GG8A 4PV4A 3BITA 1R58A 2EA4A 4U6JA 4ZWPA 2EA2A 1XGNA 2GU5A 2GG7A 3FMRA 4RGZ1 5E5BA 2ADUA 2BWUA 3IU8A 2GG0A 1A16A 1QXZA 1QXWA 2ZSGA 4U1BA 1C21A 4EGEA 2MATA 1C27A 2BHDA 3Q6DA 4IECA 2EVOA 1C22A 3FMQA 3IU7A 1R5HA 2BHCA 3CB5A 2Q96A 1CHMA 2B3HA 2GG3A 1B6AA 5JFRA 1O0XA 4IDYA 1WL9A 2P98A 4IKSA 4FKCA 2P99A 4A6WA 2NQ6A 4A6VA 2BHBA 1YVMA
chains in the Genus database with same CATH superfamily
2BH3A 4IF7A 2V6CA 3TAVA 2V3XA 1KQ0A 1WBQA 3PKBA 4U70A 1XNZA 3FM3A 3MX6A 1KQ9A 5FCFA 4U75A 4S01A 4S00A 4FO8A 4U71A 5CDVA 2B3KA 5CDEA 2IW2A 4QR8A 4JUQA 2BB7A 1W7VA 2BN7A 1N51A 4U6EA 1C24A 2Q93A 4U6CA 4U73A 2BWXA 4FLKA 3BIQA 4KM3A 2GZ5A 1KP0A 4U69A 1Y1NA 2BWTA 4Z7MA 2BWWA 2BWYA 1XGOA 1M35A 2V3ZA 3BIPA 3D27A 4RZZA 5CDLA 2NQ7A 3RORA 5JI6A 1BN5A 4HXXA 2BHAA 4S2RP 3CTZA 4S2TP 5JHUA 2EVCA 2B3LA 2GTXA 3PKAA 1WY2A 5D6EA 1BOAA 2GGBA 2OAZA 4FLIA 5D6FA 2Q94A 2GU6A 2P9AA 3MATA 5CLSA 2V3YA 2GG9A 4U6WA 3L7GA 3TB5A 4MATA 3PKEA 2GGCA 3IG4A 1QXYA 1R5GA 1QZYA 2BWVA 1WKMA 1WN1A 2EVMA 2GA2A 3PKCA 5CIKA 3RVAA 2GG5A 4IU6A 1XGSA 4RZYA 5CE6A 1WL6A 1XGMA 2GU4A 5CNXA 4ZWUA 1JAWA 1PV9A 3S6BA 2Q8KA 2Q92A 4OOKA 1MATA 1YJ3A 1B59A 2HOWA 2Q95A 4U6ZA 4B28A 4IPAA 5FCHA 4IKTA 2G6PA 3MR1A 4FLLA 4FO7A 1C23A 4FUKA 4ZWOA 4U76A 1YW7A 3PKDA 4FLJA 2OKNA 3IU9A 3L24A 2BWSA 2GG2A 4IKRA 4PNCA 1YW9A 4ZNGA 1W2MA 1WLRA 2DFIA 4IKUA 4R60A 3CB6A 1YW8A 2GU7A 2GG8A 4PV4A 3BITA 1R58A 2EA4A 4U6JA 4ZWPA 2EA2A 1XGNA 2GU5A 2GG7A 3FMRA 4RGZ1 5E5BA 2ADUA 2BWUA 3IU8A 2GG0A 1A16A 1QXZA 1QXWA 2ZSGA 4U1BA 1C21A 4EGEA 2MATA 1C27A 2BHDA 3Q6DA 4IECA 2EVOA 1C22A 3FMQA 3IU7A 1R5HA 2BHCA 3CB5A 2Q96A 1CHMA 2B3HA 2GG3A 1B6AA 5JFRA 1O0XA 4IDYA 1WL9A 2P98A 4IKSA 4FKCA 2P99A 4A6WA 2NQ6A 4A6VA 2BHBA 1YVMA
chains in the Genus database with same CATH topology
2BH3A 4IF7A 2V6CA 3TAVA 2V3XA 1KQ0A 1WBQA 3PKBA 4U70A 1XNZA 3FM3A 3MX6A 1KQ9A 5FCFA 4U75A 4S01A 4S00A 4FO8A 4U71A 5CDVA 2B3KA 5CDEA 2IW2A 4QR8A 4JUQA 2BB7A 1W7VA 2BN7A 1N51A 4U6EA 1C24A 2Q93A 4U6CA 4U73A 2BWXA 4FLKA 3BIQA 4KM3A 2GZ5A 1KP0A 4U69A 1Y1NA 2BWTA 4Z7MA 2BWWA 2BWYA 1XGOA 1M35A 2V3ZA 3BIPA 3D27A 4RZZA 5CDLA 2NQ7A 3RORA 5JI6A 1BN5A 4HXXA 2BHAA 4S2RP 3CTZA 4S2TP 5JHUA 2EVCA 2B3LA 2GTXA 3PKAA 1WY2A 5D6EA 1BOAA 2GGBA 2OAZA 4FLIA 5D6FA 2Q94A 2GU6A 2P9AA 3MATA 5CLSA 2V3YA 2GG9A 4U6WA 3L7GA 3TB5A 4MATA 3PKEA 2GGCA 3IG4A 1QXYA 1R5GA 1QZYA 2BWVA 1WKMA 1WN1A 2EVMA 2GA2A 3PKCA 5CIKA 3RVAA 2GG5A 4IU6A 1XGSA 4RZYA 5CE6A 1WL6A 1XGMA 2GU4A 5CNXA 4ZWUA 1JAWA 1PV9A 3S6BA 2Q8KA 2Q92A 4OOKA 1MATA 1YJ3A 1B59A 2HOWA 2Q95A 4U6ZA 4B28A 4IPAA 5FCHA 4IKTA 2G6PA 3MR1A 4FLLA 4FO7A 1C23A 4FUKA 4ZWOA 4U76A 1YW7A 3PKDA 4FLJA 2OKNA 3IU9A 3L24A 2BWSA 2GG2A 4IKRA 4PNCA 1YW9A 4ZNGA 1W2MA 1WLRA 2DFIA 4IKUA 4R60A 3CB6A 1YW8A 2GU7A 2GG8A 4PV4A 3BITA 1R58A 2EA4A 4U6JA 4ZWPA 2EA2A 1XGNA 2GU5A 2GG7A 3FMRA 4RGZ1 5E5BA 2ADUA 2BWUA 3IU8A 2GG0A 1A16A 1QXZA 1QXWA 2ZSGA 4U1BA 1C21A 4EGEA 2MATA 1C27A 2BHDA 3Q6DA 4IECA 2EVOA 1C22A 3FMQA 3IU7A 1R5HA 2BHCA 3CB5A 2Q96A 1CHMA 2B3HA 2GG3A 1B6AA 5JFRA 1O0XA 4IDYA 1WL9A 2P98A 4IKSA 4FKCA 2P99A 4A6WA 2NQ6A 4A6VA 2BHBA 1YVMA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BH3 A;  4IF7 A;  2V6C A;  3TAV A;  2V3X A;  1KQ0 A;  1WBQ A;  3PKB A;  4U70 A;  1XNZ A;  3FM3 A;  3MX6 A;  1KQ9 A;  5FCF A;  4U75 A;  4S01 A;  4S00 A;  4FO8 A;  4U71 A;  5CDV A;  2B3K A;  5CDE A;  2IW2 A;  4QR8 A;  4JUQ A;  2BB7 A;  1W7V A;  2BN7 A;  1N51 A;  4U6E A;  1C24 A;  2Q93 A;  4U6C A;  4U73 A;  2BWX A;  4FLK A;  3BIQ A;  4KM3 A;  2GZ5 A;  1KP0 A;  4U69 A;  1Y1N A;  2BWT A;  4Z7M A;  2BWW A;  2BWY A;  1XGO A;  1M35 A;  2V3Z A;  3BIP A;  3D27 A;  4RZZ A;  5CDL A;  2NQ7 A;  3ROR A;  5JI6 A;  1BN5 A;  4HXX A;  2BHA A;  4S2R P;  3CTZ A;  4S2T P;  5JHU A;  2EVC A;  2B3L A;  2GTX A;  3PKA A;  1WY2 A;  5D6E A;  1BOA A;  2GGB A;  2OAZ A;  4FLI A;  5D6F A;  2Q94 A;  2GU6 A;  2P9A A;  3MAT A;  5CLS A;  2V3Y A;  2GG9 A;  4U6W A;  3L7G A;  3TB5 A;  4MAT A;  3PKE A;  2GGC A;  3IG4 A;  1QXY A;  1R5G A;  1QZY A;  2BWV A;  1WKM A;  1WN1 A;  2EVM A;  2GA2 A;  3PKC A;  5CIK A;  3RVA A;  2GG5 A;  4IU6 A;  1XGS A;  4RZY A;  5CE6 A;  1WL6 A;  1XGM A;  2GU4 A;  5CNX A;  4ZWU A;  1JAW A;  1PV9 A;  3S6B A;  2Q8K A;  2Q92 A;  4OOK A;  1MAT A;  1YJ3 A;  1B59 A;  2HOW A;  2Q95 A;  4U6Z A;  4B28 A;  4IPA A;  5FCH A;  4IKT A;  2G6P A;  3MR1 A;  4FLL A;  4FO7 A;  1C23 A;  4FUK A;  4ZWO A;  4U76 A;  1YW7 A;  3PKD A;  4FLJ A;  2OKN A;  3IU9 A;  3L24 A;  2BWS A;  2GG2 A;  4IKR A;  4PNC A;  1YW9 A;  4ZNG A;  1W2M A;  1WLR A;  2DFI A;  4IKU A;  4R60 A;  3CB6 A;  1YW8 A;  2GU7 A;  2GG8 A;  4PV4 A;  3BIT A;  1R58 A;  2EA4 A;  4U6J A;  4ZWP A;  2EA2 A;  1XGN A;  2GU5 A;  2GG7 A;  3FMR A;  4RGZ 1;  5E5B A;  2ADU A;  2BWU A;  3IU8 A;  2GG0 A;  1A16 A;  1QXZ A;  1QXW A;  2ZSG A;  4U1B A;  1C21 A;  4EGE A;  2MAT A;  1C27 A;  2BHD A;  3Q6D A;  4IEC A;  2EVO A;  1C22 A;  3FMQ A;  3IU7 A;  1R5H A;  2BHC A;  3CB5 A;  2Q96 A;  1CHM A;  2B3H A;  2GG3 A;  1B6A A;  5JFR A;  1O0X A;  4IDY A;  1WL9 A;  2P98 A;  4IKS A;  4FKC A;  2P99 A;  4A6W A;  2NQ6 A;  4A6V A;  2BHB A;  1YVM A; 
#chains in the Genus database with same CATH topology
 2BH3 A;  4IF7 A;  2V6C A;  3TAV A;  2V3X A;  1KQ0 A;  1WBQ A;  3PKB A;  4U70 A;  1XNZ A;  3FM3 A;  3MX6 A;  1KQ9 A;  5FCF A;  4U75 A;  4S01 A;  4S00 A;  4FO8 A;  4U71 A;  5CDV A;  2B3K A;  5CDE A;  2IW2 A;  4QR8 A;  4JUQ A;  2BB7 A;  1W7V A;  2BN7 A;  1N51 A;  4U6E A;  1C24 A;  2Q93 A;  4U6C A;  4U73 A;  2BWX A;  4FLK A;  3BIQ A;  4KM3 A;  2GZ5 A;  1KP0 A;  4U69 A;  1Y1N A;  2BWT A;  4Z7M A;  2BWW A;  2BWY A;  1XGO A;  1M35 A;  2V3Z A;  3BIP A;  3D27 A;  4RZZ A;  5CDL A;  2NQ7 A;  3ROR A;  5JI6 A;  1BN5 A;  4HXX A;  2BHA A;  4S2R P;  3CTZ A;  4S2T P;  5JHU A;  2EVC A;  2B3L A;  2GTX A;  3PKA A;  1WY2 A;  5D6E A;  1BOA A;  2GGB A;  2OAZ A;  4FLI A;  5D6F A;  2Q94 A;  2GU6 A;  2P9A A;  3MAT A;  5CLS A;  2V3Y A;  2GG9 A;  4U6W A;  3L7G A;  3TB5 A;  4MAT A;  3PKE A;  2GGC A;  3IG4 A;  1QXY A;  1R5G A;  1QZY A;  2BWV A;  1WKM A;  1WN1 A;  2EVM A;  2GA2 A;  3PKC A;  5CIK A;  3RVA A;  2GG5 A;  4IU6 A;  1XGS A;  4RZY A;  5CE6 A;  1WL6 A;  1XGM A;  2GU4 A;  5CNX A;  4ZWU A;  1JAW A;  1PV9 A;  3S6B A;  2Q8K A;  2Q92 A;  4OOK A;  1MAT A;  1YJ3 A;  1B59 A;  2HOW A;  2Q95 A;  4U6Z A;  4B28 A;  4IPA A;  5FCH A;  4IKT A;  2G6P A;  3MR1 A;  4FLL A;  4FO7 A;  1C23 A;  4FUK A;  4ZWO A;  4U76 A;  1YW7 A;  3PKD A;  4FLJ A;  2OKN A;  3IU9 A;  3L24 A;  2BWS A;  2GG2 A;  4IKR A;  4PNC A;  1YW9 A;  4ZNG A;  1W2M A;  1WLR A;  2DFI A;  4IKU A;  4R60 A;  3CB6 A;  1YW8 A;  2GU7 A;  2GG8 A;  4PV4 A;  3BIT A;  1R58 A;  2EA4 A;  4U6J A;  4ZWP A;  2EA2 A;  1XGN A;  2GU5 A;  2GG7 A;  3FMR A;  4RGZ 1;  5E5B A;  2ADU A;  2BWU A;  3IU8 A;  2GG0 A;  1A16 A;  1QXZ A;  1QXW A;  2ZSG A;  4U1B A;  1C21 A;  4EGE A;  2MAT A;  1C27 A;  2BHD A;  3Q6D A;  4IEC A;  2EVO A;  1C22 A;  3FMQ A;  3IU7 A;  1R5H A;  2BHC A;  3CB5 A;  2Q96 A;  1CHM A;  2B3H A;  2GG3 A;  1B6A A;  5JFR A;  1O0X A;  4IDY A;  1WL9 A;  2P98 A;  4IKS A;  4FKC A;  2P99 A;  4A6W A;  2NQ6 A;  4A6V A;  2BHB A;  1YVM A; 
#chains in the Genus database with same CATH homology
 2BH3 A;  4IF7 A;  2V6C A;  3TAV A;  2V3X A;  1KQ0 A;  1WBQ A;  3PKB A;  4U70 A;  1XNZ A;  3FM3 A;  3MX6 A;  1KQ9 A;  5FCF A;  4U75 A;  4S01 A;  4S00 A;  4FO8 A;  4U71 A;  5CDV A;  2B3K A;  5CDE A;  2IW2 A;  4QR8 A;  4JUQ A;  2BB7 A;  1W7V A;  2BN7 A;  1N51 A;  4U6E A;  1C24 A;  2Q93 A;  4U6C A;  4U73 A;  2BWX A;  4FLK A;  3BIQ A;  4KM3 A;  2GZ5 A;  1KP0 A;  4U69 A;  1Y1N A;  2BWT A;  4Z7M A;  2BWW A;  2BWY A;  1XGO A;  1M35 A;  2V3Z A;  3BIP A;  3D27 A;  4RZZ A;  5CDL A;  2NQ7 A;  3ROR A;  5JI6 A;  1BN5 A;  4HXX A;  2BHA A;  4S2R P;  3CTZ A;  4S2T P;  5JHU A;  2EVC A;  2B3L A;  2GTX A;  3PKA A;  1WY2 A;  5D6E A;  1BOA A;  2GGB A;  2OAZ A;  4FLI A;  5D6F A;  2Q94 A;  2GU6 A;  2P9A A;  3MAT A;  5CLS A;  2V3Y A;  2GG9 A;  4U6W A;  3L7G A;  3TB5 A;  4MAT A;  3PKE A;  2GGC A;  3IG4 A;  1QXY A;  1R5G A;  1QZY A;  2BWV A;  1WKM A;  1WN1 A;  2EVM A;  2GA2 A;  3PKC A;  5CIK A;  3RVA A;  2GG5 A;  4IU6 A;  1XGS A;  4RZY A;  5CE6 A;  1WL6 A;  1XGM A;  2GU4 A;  5CNX A;  4ZWU A;  1JAW A;  1PV9 A;  3S6B A;  2Q8K A;  2Q92 A;  4OOK A;  1MAT A;  1YJ3 A;  1B59 A;  2HOW A;  2Q95 A;  4U6Z A;  4B28 A;  4IPA A;  5FCH A;  4IKT A;  2G6P A;  3MR1 A;  4FLL A;  4FO7 A;  1C23 A;  4FUK A;  4ZWO A;  4U76 A;  1YW7 A;  3PKD A;  4FLJ A;  2OKN A;  3IU9 A;  3L24 A;  2BWS A;  2GG2 A;  4IKR A;  4PNC A;  1YW9 A;  4ZNG A;  1W2M A;  1WLR A;  2DFI A;  4IKU A;  4R60 A;  3CB6 A;  1YW8 A;  2GU7 A;  2GG8 A;  4PV4 A;  3BIT A;  1R58 A;  2EA4 A;  4U6J A;  4ZWP A;  2EA2 A;  1XGN A;  2GU5 A;  2GG7 A;  3FMR A;  4RGZ 1;  5E5B A;  2ADU A;  2BWU A;  3IU8 A;  2GG0 A;  1A16 A;  1QXZ A;  1QXW A;  2ZSG A;  4U1B A;  1C21 A;  4EGE A;  2MAT A;  1C27 A;  2BHD A;  3Q6D A;  4IEC A;  2EVO A;  1C22 A;  3FMQ A;  3IU7 A;  1R5H A;  2BHC A;  3CB5 A;  2Q96 A;  1CHM A;  2B3H A;  2GG3 A;  1B6A A;  5JFR A;  1O0X A;  4IDY A;  1WL9 A;  2P98 A;  4IKS A;  4FKC A;  2P99 A;  4A6W A;  2NQ6 A;  4A6V A;  2BHB A;  1YVM A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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