2GG8A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Escherichia coli k12
total genus 88
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg8A00
3BIQA 1WLRA 2BWUA 4FUKA 4MATA 5CDVA 5FCHA 2GG3A 4FLIA 4RZYA 1QXWA 1PV9A 2EVMA 2GG9A 2Q92A 2Q96A 2GU6A 4KM3A 4RGZ1 1C24A 2GZ5A 3FMQA 1M35A 3PKAA 1XGMA 3PKBA 2BWSA 2B3HA 2HOWA 2ADUA 2G6PA 4U73A 4A6VA 1B6AA 2BN7A 5JHUA 1A16A 3IU8A 5JFRA 1Y1NA 4S2TP 1R58A 2GU7A 3S6BA 1YJ3A 2B3LA 2GG5A 1WL6A 2ZSGA 3MATA 4U69A 4U75A 2BHBA 2V3YA 4FLLA 4ZNGA 1WY2A 4PNCA 5CDEA 1KQ9A 2OKNA 1YW9A 4IKUA 4U71A 1W2MA 2Q93A 2EA4A 2GGCA 3FM3A 4JUQA 4B28A 3PKDA 4U6WA 2NQ7A 4IDYA 3RVAA 1JAWA 1WL9A 1KP0A 3TB5A 1C21A 3Q6DA 1O0XA 1R5HA 2MATA 4S2RP 1YW8A 1QXZA 2DFIA 4A6WA 3CTZA 4FKCA 3L24A 2BHAA 3MR1A 2EVOA 3IG4A 3IU7A 2EVCA 1R5GA 1BN5A 2GU5A 2Q95A 3CB6A 2BHDA 2V6CA 5CNXA 3L7GA 3BITA 2GG8A 4IKTA 4FLKA 4ZWUA 1C27A 1WKMA 4RZZA 1B59A 2Q8KA 4S00A 4IU6A 3RORA 4EGEA 1W7VA 4ZWOA 2Q94A 1XGSA 1CHMA 3D27A 4QR8A 1KQ0A 1WN1A 2GU4A 2V3ZA 4IKRA 2B3KA 4U70A 4HXXA 3BIPA 3IU9A 5CLSA 4U6CA 4IPAA 1C22A 2OAZA 2GG0A 1YVMA 4R60A 4FLJA 5FCFA 4FO8A 2IW2A 1BOAA 4S01A 2GA2A 1MATA 5D6EA 2BWXA 4U1BA 3PKEA 4U6JA 5E5BA 4IF7A 4FO7A 2NQ6A 4IKSA 1QXYA 3FMRA 1YW7A 2P9AA 2BWYA 5CIKA 2EA2A 2P98A 4U6ZA 2BWTA 1XGNA 5D6FA 1XGOA 2BB7A 3TAVA 1XNZA 5JI6A 2BH3A 4IECA 4U76A 4ZWPA 4U6EA 1QZYA 1WBQA 5CE6A 1N51A 3PKCA 4OOKA 2BWVA 4Z7MA 2P99A 1C23A 5CDLA 2BWWA 2GG2A 2GG7A 2V3XA 2BHCA 4PV4A 2GTXA 3CB5A 3MX6A 2GGBA
chains in the Genus database with same CATH superfamily
3BIQA 1WLRA 2BWUA 4FUKA 4MATA 5CDVA 5FCHA 2GG3A 4FLIA 4RZYA 1QXWA 1PV9A 2EVMA 2GG9A 2Q92A 2Q96A 2GU6A 4KM3A 4RGZ1 1C24A 2GZ5A 3FMQA 1M35A 3PKAA 1XGMA 3PKBA 2BWSA 2B3HA 2HOWA 2ADUA 2G6PA 4U73A 4A6VA 1B6AA 2BN7A 5JHUA 1A16A 3IU8A 5JFRA 1Y1NA 4S2TP 1R58A 2GU7A 3S6BA 1YJ3A 2B3LA 2GG5A 1WL6A 2ZSGA 3MATA 4U69A 4U75A 2BHBA 2V3YA 4FLLA 4ZNGA 1WY2A 4PNCA 5CDEA 1KQ9A 2OKNA 1YW9A 4IKUA 4U71A 1W2MA 2Q93A 2EA4A 2GGCA 3FM3A 4JUQA 4B28A 3PKDA 4U6WA 2NQ7A 4IDYA 3RVAA 1JAWA 1WL9A 1KP0A 3TB5A 1C21A 3Q6DA 1O0XA 1R5HA 2MATA 4S2RP 1YW8A 1QXZA 2DFIA 4A6WA 3CTZA 4FKCA 3L24A 2BHAA 3MR1A 2EVOA 3IG4A 3IU7A 2EVCA 1R5GA 1BN5A 2GU5A 2Q95A 3CB6A 2BHDA 2V6CA 5CNXA 3L7GA 3BITA 2GG8A 4IKTA 4FLKA 4ZWUA 1C27A 1WKMA 4RZZA 1B59A 2Q8KA 4S00A 4IU6A 3RORA 4EGEA 1W7VA 4ZWOA 2Q94A 1XGSA 1CHMA 3D27A 4QR8A 1KQ0A 1WN1A 2GU4A 2V3ZA 4IKRA 2B3KA 4U70A 4HXXA 3BIPA 3IU9A 5CLSA 4U6CA 4IPAA 1C22A 2OAZA 2GG0A 1YVMA 4R60A 4FLJA 5FCFA 4FO8A 2IW2A 1BOAA 4S01A 2GA2A 1MATA 5D6EA 2BWXA 4U1BA 3PKEA 4U6JA 5E5BA 4IF7A 4FO7A 2NQ6A 4IKSA 1QXYA 3FMRA 1YW7A 2P9AA 2BWYA 5CIKA 2EA2A 2P98A 4U6ZA 2BWTA 1XGNA 5D6FA 1XGOA 2BB7A 3TAVA 1XNZA 5JI6A 2BH3A 4IECA 4U76A 4ZWPA 4U6EA 1QZYA 1WBQA 5CE6A 1N51A 3PKCA 4OOKA 2BWVA 4Z7MA 2P99A 1C23A 5CDLA 2BWWA 2GG2A 2GG7A 2V3XA 2BHCA 4PV4A 2GTXA 3CB5A 3MX6A 2GGBA
chains in the Genus database with same CATH topology
3BIQA 1WLRA 2BWUA 4FUKA 4MATA 5CDVA 5FCHA 2GG3A 4FLIA 4RZYA 1QXWA 1PV9A 2EVMA 2GG9A 2Q92A 2Q96A 2GU6A 4KM3A 4RGZ1 1C24A 2GZ5A 3FMQA 1M35A 3PKAA 1XGMA 3PKBA 2BWSA 2B3HA 2HOWA 2ADUA 2G6PA 4U73A 4A6VA 1B6AA 2BN7A 5JHUA 1A16A 3IU8A 5JFRA 1Y1NA 4S2TP 1R58A 2GU7A 3S6BA 1YJ3A 2B3LA 2GG5A 1WL6A 2ZSGA 3MATA 4U69A 4U75A 2BHBA 2V3YA 4FLLA 4ZNGA 1WY2A 4PNCA 5CDEA 1KQ9A 2OKNA 1YW9A 4IKUA 4U71A 1W2MA 2Q93A 2EA4A 2GGCA 3FM3A 4JUQA 4B28A 3PKDA 4U6WA 2NQ7A 4IDYA 3RVAA 1JAWA 1WL9A 1KP0A 3TB5A 1C21A 3Q6DA 1O0XA 1R5HA 2MATA 4S2RP 1YW8A 1QXZA 2DFIA 4A6WA 3CTZA 4FKCA 3L24A 2BHAA 3MR1A 2EVOA 3IG4A 3IU7A 2EVCA 1R5GA 1BN5A 2GU5A 2Q95A 3CB6A 2BHDA 2V6CA 5CNXA 3L7GA 3BITA 2GG8A 4IKTA 4FLKA 4ZWUA 1C27A 1WKMA 4RZZA 1B59A 2Q8KA 4S00A 4IU6A 3RORA 4EGEA 1W7VA 4ZWOA 2Q94A 1XGSA 1CHMA 3D27A 4QR8A 1KQ0A 1WN1A 2GU4A 2V3ZA 4IKRA 2B3KA 4U70A 4HXXA 3BIPA 3IU9A 5CLSA 4U6CA 4IPAA 1C22A 2OAZA 2GG0A 1YVMA 4R60A 4FLJA 5FCFA 4FO8A 2IW2A 1BOAA 4S01A 2GA2A 1MATA 5D6EA 2BWXA 4U1BA 3PKEA 4U6JA 5E5BA 4IF7A 4FO7A 2NQ6A 4IKSA 1QXYA 3FMRA 1YW7A 2P9AA 2BWYA 5CIKA 2EA2A 2P98A 4U6ZA 2BWTA 1XGNA 5D6FA 1XGOA 2BB7A 3TAVA 1XNZA 5JI6A 2BH3A 4IECA 4U76A 4ZWPA 4U6EA 1QZYA 1WBQA 5CE6A 1N51A 3PKCA 4OOKA 2BWVA 4Z7MA 2P99A 1C23A 5CDLA 2BWWA 2GG2A 2GG7A 2V3XA 2BHCA 4PV4A 2GTXA 3CB5A 3MX6A 2GGBA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3BIQ A;  1WLR A;  2BWU A;  4FUK A;  4MAT A;  5CDV A;  5FCH A;  2GG3 A;  4FLI A;  4RZY A;  1QXW A;  1PV9 A;  2EVM A;  2GG9 A;  2Q92 A;  2Q96 A;  2GU6 A;  4KM3 A;  4RGZ 1;  1C24 A;  2GZ5 A;  3FMQ A;  1M35 A;  3PKA A;  1XGM A;  3PKB A;  2BWS A;  2B3H A;  2HOW A;  2ADU A;  2G6P A;  4U73 A;  4A6V A;  1B6A A;  2BN7 A;  5JHU A;  1A16 A;  3IU8 A;  5JFR A;  1Y1N A;  4S2T P;  1R58 A;  2GU7 A;  3S6B A;  1YJ3 A;  2B3L A;  2GG5 A;  1WL6 A;  2ZSG A;  3MAT A;  4U69 A;  4U75 A;  2BHB A;  2V3Y A;  4FLL A;  4ZNG A;  1WY2 A;  4PNC A;  5CDE A;  1KQ9 A;  2OKN A;  1YW9 A;  4IKU A;  4U71 A;  1W2M A;  2Q93 A;  2EA4 A;  2GGC A;  3FM3 A;  4JUQ A;  4B28 A;  3PKD A;  4U6W A;  2NQ7 A;  4IDY A;  3RVA A;  1JAW A;  1WL9 A;  1KP0 A;  3TB5 A;  1C21 A;  3Q6D A;  1O0X A;  1R5H A;  2MAT A;  4S2R P;  1YW8 A;  1QXZ A;  2DFI A;  4A6W A;  3CTZ A;  4FKC A;  3L24 A;  2BHA A;  3MR1 A;  2EVO A;  3IG4 A;  3IU7 A;  2EVC A;  1R5G A;  1BN5 A;  2GU5 A;  2Q95 A;  3CB6 A;  2BHD A;  2V6C A;  5CNX A;  3L7G A;  3BIT A;  2GG8 A;  4IKT A;  4FLK A;  4ZWU A;  1C27 A;  1WKM A;  4RZZ A;  1B59 A;  2Q8K A;  4S00 A;  4IU6 A;  3ROR A;  4EGE A;  1W7V A;  4ZWO A;  2Q94 A;  1XGS A;  1CHM A;  3D27 A;  4QR8 A;  1KQ0 A;  1WN1 A;  2GU4 A;  2V3Z A;  4IKR A;  2B3K A;  4U70 A;  4HXX A;  3BIP A;  3IU9 A;  5CLS A;  4U6C A;  4IPA A;  1C22 A;  2OAZ A;  2GG0 A;  1YVM A;  4R60 A;  4FLJ A;  5FCF A;  4FO8 A;  2IW2 A;  1BOA A;  4S01 A;  2GA2 A;  1MAT A;  5D6E A;  2BWX A;  4U1B A;  3PKE A;  4U6J A;  5E5B A;  4IF7 A;  4FO7 A;  2NQ6 A;  4IKS A;  1QXY A;  3FMR A;  1YW7 A;  2P9A A;  2BWY A;  5CIK A;  2EA2 A;  2P98 A;  4U6Z A;  2BWT A;  1XGN A;  5D6F A;  1XGO A;  2BB7 A;  3TAV A;  1XNZ A;  5JI6 A;  2BH3 A;  4IEC A;  4U76 A;  4ZWP A;  4U6E A;  1QZY A;  1WBQ A;  5CE6 A;  1N51 A;  3PKC A;  4OOK A;  2BWV A;  4Z7M A;  2P99 A;  1C23 A;  5CDL A;  2BWW A;  2GG2 A;  2GG7 A;  2V3X A;  2BHC A;  4PV4 A;  2GTX A;  3CB5 A;  3MX6 A;  2GGB A; 
#chains in the Genus database with same CATH topology
 3BIQ A;  1WLR A;  2BWU A;  4FUK A;  4MAT A;  5CDV A;  5FCH A;  2GG3 A;  4FLI A;  4RZY A;  1QXW A;  1PV9 A;  2EVM A;  2GG9 A;  2Q92 A;  2Q96 A;  2GU6 A;  4KM3 A;  4RGZ 1;  1C24 A;  2GZ5 A;  3FMQ A;  1M35 A;  3PKA A;  1XGM A;  3PKB A;  2BWS A;  2B3H A;  2HOW A;  2ADU A;  2G6P A;  4U73 A;  4A6V A;  1B6A A;  2BN7 A;  5JHU A;  1A16 A;  3IU8 A;  5JFR A;  1Y1N A;  4S2T P;  1R58 A;  2GU7 A;  3S6B A;  1YJ3 A;  2B3L A;  2GG5 A;  1WL6 A;  2ZSG A;  3MAT A;  4U69 A;  4U75 A;  2BHB A;  2V3Y A;  4FLL A;  4ZNG A;  1WY2 A;  4PNC A;  5CDE A;  1KQ9 A;  2OKN A;  1YW9 A;  4IKU A;  4U71 A;  1W2M A;  2Q93 A;  2EA4 A;  2GGC A;  3FM3 A;  4JUQ A;  4B28 A;  3PKD A;  4U6W A;  2NQ7 A;  4IDY A;  3RVA A;  1JAW A;  1WL9 A;  1KP0 A;  3TB5 A;  1C21 A;  3Q6D A;  1O0X A;  1R5H A;  2MAT A;  4S2R P;  1YW8 A;  1QXZ A;  2DFI A;  4A6W A;  3CTZ A;  4FKC A;  3L24 A;  2BHA A;  3MR1 A;  2EVO A;  3IG4 A;  3IU7 A;  2EVC A;  1R5G A;  1BN5 A;  2GU5 A;  2Q95 A;  3CB6 A;  2BHD A;  2V6C A;  5CNX A;  3L7G A;  3BIT A;  2GG8 A;  4IKT A;  4FLK A;  4ZWU A;  1C27 A;  1WKM A;  4RZZ A;  1B59 A;  2Q8K A;  4S00 A;  4IU6 A;  3ROR A;  4EGE A;  1W7V A;  4ZWO A;  2Q94 A;  1XGS A;  1CHM A;  3D27 A;  4QR8 A;  1KQ0 A;  1WN1 A;  2GU4 A;  2V3Z A;  4IKR A;  2B3K A;  4U70 A;  4HXX A;  3BIP A;  3IU9 A;  5CLS A;  4U6C A;  4IPA A;  1C22 A;  2OAZ A;  2GG0 A;  1YVM A;  4R60 A;  4FLJ A;  5FCF A;  4FO8 A;  2IW2 A;  1BOA A;  4S01 A;  2GA2 A;  1MAT A;  5D6E A;  2BWX A;  4U1B A;  3PKE A;  4U6J A;  5E5B A;  4IF7 A;  4FO7 A;  2NQ6 A;  4IKS A;  1QXY A;  3FMR A;  1YW7 A;  2P9A A;  2BWY A;  5CIK A;  2EA2 A;  2P98 A;  4U6Z A;  2BWT A;  1XGN A;  5D6F A;  1XGO A;  2BB7 A;  3TAV A;  1XNZ A;  5JI6 A;  2BH3 A;  4IEC A;  4U76 A;  4ZWP A;  4U6E A;  1QZY A;  1WBQ A;  5CE6 A;  1N51 A;  3PKC A;  4OOK A;  2BWV A;  4Z7M A;  2P99 A;  1C23 A;  5CDL A;  2BWW A;  2GG2 A;  2GG7 A;  2V3X A;  2BHC A;  4PV4 A;  2GTX A;  3CB5 A;  3MX6 A;  2GGB A; 
#chains in the Genus database with same CATH homology
 3BIQ A;  1WLR A;  2BWU A;  4FUK A;  4MAT A;  5CDV A;  5FCH A;  2GG3 A;  4FLI A;  4RZY A;  1QXW A;  1PV9 A;  2EVM A;  2GG9 A;  2Q92 A;  2Q96 A;  2GU6 A;  4KM3 A;  4RGZ 1;  1C24 A;  2GZ5 A;  3FMQ A;  1M35 A;  3PKA A;  1XGM A;  3PKB A;  2BWS A;  2B3H A;  2HOW A;  2ADU A;  2G6P A;  4U73 A;  4A6V A;  1B6A A;  2BN7 A;  5JHU A;  1A16 A;  3IU8 A;  5JFR A;  1Y1N A;  4S2T P;  1R58 A;  2GU7 A;  3S6B A;  1YJ3 A;  2B3L A;  2GG5 A;  1WL6 A;  2ZSG A;  3MAT A;  4U69 A;  4U75 A;  2BHB A;  2V3Y A;  4FLL A;  4ZNG A;  1WY2 A;  4PNC A;  5CDE A;  1KQ9 A;  2OKN A;  1YW9 A;  4IKU A;  4U71 A;  1W2M A;  2Q93 A;  2EA4 A;  2GGC A;  3FM3 A;  4JUQ A;  4B28 A;  3PKD A;  4U6W A;  2NQ7 A;  4IDY A;  3RVA A;  1JAW A;  1WL9 A;  1KP0 A;  3TB5 A;  1C21 A;  3Q6D A;  1O0X A;  1R5H A;  2MAT A;  4S2R P;  1YW8 A;  1QXZ A;  2DFI A;  4A6W A;  3CTZ A;  4FKC A;  3L24 A;  2BHA A;  3MR1 A;  2EVO A;  3IG4 A;  3IU7 A;  2EVC A;  1R5G A;  1BN5 A;  2GU5 A;  2Q95 A;  3CB6 A;  2BHD A;  2V6C A;  5CNX A;  3L7G A;  3BIT A;  2GG8 A;  4IKT A;  4FLK A;  4ZWU A;  1C27 A;  1WKM A;  4RZZ A;  1B59 A;  2Q8K A;  4S00 A;  4IU6 A;  3ROR A;  4EGE A;  1W7V A;  4ZWO A;  2Q94 A;  1XGS A;  1CHM A;  3D27 A;  4QR8 A;  1KQ0 A;  1WN1 A;  2GU4 A;  2V3Z A;  4IKR A;  2B3K A;  4U70 A;  4HXX A;  3BIP A;  3IU9 A;  5CLS A;  4U6C A;  4IPA A;  1C22 A;  2OAZ A;  2GG0 A;  1YVM A;  4R60 A;  4FLJ A;  5FCF A;  4FO8 A;  2IW2 A;  1BOA A;  4S01 A;  2GA2 A;  1MAT A;  5D6E A;  2BWX A;  4U1B A;  3PKE A;  4U6J A;  5E5B A;  4IF7 A;  4FO7 A;  2NQ6 A;  4IKS A;  1QXY A;  3FMR A;  1YW7 A;  2P9A A;  2BWY A;  5CIK A;  2EA2 A;  2P98 A;  4U6Z A;  2BWT A;  1XGN A;  5D6F A;  1XGO A;  2BB7 A;  3TAV A;  1XNZ A;  5JI6 A;  2BH3 A;  4IEC A;  4U76 A;  4ZWP A;  4U6E A;  1QZY A;  1WBQ A;  5CE6 A;  1N51 A;  3PKC A;  4OOK A;  2BWV A;  4Z7M A;  2P99 A;  1C23 A;  5CDL A;  2BWW A;  2GG2 A;  2GG7 A;  2V3X A;  2BHC A;  4PV4 A;  2GTX A;  3CB5 A;  3MX6 A;  2GGB A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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