2B3LA

Crystal structure of type i human methionine aminopeptidase in the apo form
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
305
structure length
305
Chain Sequence
PYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 98
structure length 305
sequence length 305
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2b3lA00
4U6ZA 2EA2A 1Y1NA 1JAWA 4IPAA 4ZWOA 1BN5A 5CDLA 4S00A 4U6JA 3RVAA 1B59A 3D27A 4FLLA 3MX6A 1M35A 2Q94A 2GZ5A 1YW7A 2GG3A 1R5GA 3TAVA 1KQ9A 3IU7A 4U69A 2GTXA 3BIQA 2BN7A 3CB6A 4IKRA 3PKBA 3MR1A 4A6VA 2BWYA 3L7GA 3MATA 4U75A 5FCFA 3IG4A 2BWTA 2BHDA 4IDYA 5CE6A 1WKMA 4IU6A 2BWWA 1YJ3A 3PKAA 4U1BA 1XGOA 4IKSA 4JUQA 4S2RP 2GA2A 2Q93A 3IU9A 1A16A 4OOKA 2MATA 2GU6A 4IF7A 2HOWA 5E5BA 5JI6A 3CTZA 2EVMA 2Q8KA 2V3ZA 2B3HA 2V6CA 4FO7A 4S2TP 3PKDA 1R5HA 2ADUA 2EA4A 3Q6DA 1CHMA 2Q96A 4HXXA 1C23A 4MATA 5CIKA 1XGSA 4U71A 4IECA 4B28A 1W7VA 1YW9A 4IKUA 2BH3A 4FO8A 2BHBA 2OAZA 3BITA 1BOAA 4U6WA 3IU8A 4EGEA 1YVMA 2GG8A 1W2MA 2ZSGA 4ZWPA 1XNZA 1C22A 5JFRA 4Z7MA 3FMQA 2V3XA 4ZNGA 4FLKA 2GGCA 1WN1A 2IW2A 2EVCA 4U6CA 2GG5A 4RZZA 4R60A 2GG9A 1YW8A 2BHCA 2G6PA 3BIPA 1KP0A 1QXZA 5D6FA 1XGNA 3FM3A 4RGZ1 3S6BA 2DFIA 3PKEA 2OKNA 2GU4A 2Q92A 2BWVA 1WL9A 3L24A 2BHAA 1C24A 1WL6A 4FKCA 4KM3A 2B3KA 1WLRA 1XGMA 1PV9A 4PV4A 2Q95A 5CDVA 2GG7A 2BWSA 2B3LA 2BB7A 4ZWUA 5FCHA 1MATA 1R58A 1QXYA 2BWUA 1QXWA 2EVOA 3TB5A 5CLSA 4FLIA 5CNXA 2GG2A 1N51A 3PKCA 3CB5A 3RORA 1WY2A 5JHUA 4U70A 4RZYA 1C27A 1C21A 2V3YA 5CDEA 2BWXA 4A6WA 1B6AA 4S01A 5D6EA 4U76A 4FUKA 2GG0A 4QR8A 2P98A 1WBQA 1O0XA 2P9AA 4PNCA 2NQ7A 1KQ0A 2GU5A 3FMRA 4FLJA 1QZYA 4U6EA 2GU7A 4U73A 2P99A 2NQ6A 4IKTA 2GGBA
chains in the Genus database with same CATH superfamily
4U6ZA 2EA2A 1Y1NA 1JAWA 4IPAA 4ZWOA 1BN5A 5CDLA 4S00A 4U6JA 3RVAA 1B59A 3D27A 4FLLA 3MX6A 1M35A 2Q94A 2GZ5A 1YW7A 2GG3A 1R5GA 3TAVA 1KQ9A 3IU7A 4U69A 2GTXA 3BIQA 2BN7A 3CB6A 4IKRA 3PKBA 3MR1A 4A6VA 2BWYA 3L7GA 3MATA 4U75A 5FCFA 3IG4A 2BWTA 2BHDA 4IDYA 5CE6A 1WKMA 4IU6A 2BWWA 1YJ3A 3PKAA 4U1BA 1XGOA 4IKSA 4JUQA 4S2RP 2GA2A 2Q93A 3IU9A 1A16A 4OOKA 2MATA 2GU6A 4IF7A 2HOWA 5E5BA 5JI6A 3CTZA 2EVMA 2Q8KA 2V3ZA 2B3HA 2V6CA 4FO7A 4S2TP 3PKDA 1R5HA 2ADUA 2EA4A 3Q6DA 1CHMA 2Q96A 4HXXA 1C23A 4MATA 5CIKA 1XGSA 4U71A 4IECA 4B28A 1W7VA 1YW9A 4IKUA 2BH3A 4FO8A 2BHBA 2OAZA 3BITA 1BOAA 4U6WA 3IU8A 4EGEA 1YVMA 2GG8A 1W2MA 2ZSGA 4ZWPA 1XNZA 1C22A 5JFRA 4Z7MA 3FMQA 2V3XA 4ZNGA 4FLKA 2GGCA 1WN1A 2IW2A 2EVCA 4U6CA 2GG5A 4RZZA 4R60A 2GG9A 1YW8A 2BHCA 2G6PA 3BIPA 1KP0A 1QXZA 5D6FA 1XGNA 3FM3A 4RGZ1 3S6BA 2DFIA 3PKEA 2OKNA 2GU4A 2Q92A 2BWVA 1WL9A 3L24A 2BHAA 1C24A 1WL6A 4FKCA 4KM3A 2B3KA 1WLRA 1XGMA 1PV9A 4PV4A 2Q95A 5CDVA 2GG7A 2BWSA 2B3LA 2BB7A 4ZWUA 5FCHA 1MATA 1R58A 1QXYA 2BWUA 1QXWA 2EVOA 3TB5A 5CLSA 4FLIA 5CNXA 2GG2A 1N51A 3PKCA 3CB5A 3RORA 1WY2A 5JHUA 4U70A 4RZYA 1C27A 1C21A 2V3YA 5CDEA 2BWXA 4A6WA 1B6AA 4S01A 5D6EA 4U76A 4FUKA 2GG0A 4QR8A 2P98A 1WBQA 1O0XA 2P9AA 4PNCA 2NQ7A 1KQ0A 2GU5A 3FMRA 4FLJA 1QZYA 4U6EA 2GU7A 4U73A 2P99A 2NQ6A 4IKTA 2GGBA
chains in the Genus database with same CATH topology
4U6ZA 2EA2A 1Y1NA 1JAWA 4IPAA 4ZWOA 1BN5A 5CDLA 4S00A 4U6JA 3RVAA 1B59A 3D27A 4FLLA 3MX6A 1M35A 2Q94A 2GZ5A 1YW7A 2GG3A 1R5GA 3TAVA 1KQ9A 3IU7A 4U69A 2GTXA 3BIQA 2BN7A 3CB6A 4IKRA 3PKBA 3MR1A 4A6VA 2BWYA 3L7GA 3MATA 4U75A 5FCFA 3IG4A 2BWTA 2BHDA 4IDYA 5CE6A 1WKMA 4IU6A 2BWWA 1YJ3A 3PKAA 4U1BA 1XGOA 4IKSA 4JUQA 4S2RP 2GA2A 2Q93A 3IU9A 1A16A 4OOKA 2MATA 2GU6A 4IF7A 2HOWA 5E5BA 5JI6A 3CTZA 2EVMA 2Q8KA 2V3ZA 2B3HA 2V6CA 4FO7A 4S2TP 3PKDA 1R5HA 2ADUA 2EA4A 3Q6DA 1CHMA 2Q96A 4HXXA 1C23A 4MATA 5CIKA 1XGSA 4U71A 4IECA 4B28A 1W7VA 1YW9A 4IKUA 2BH3A 4FO8A 2BHBA 2OAZA 3BITA 1BOAA 4U6WA 3IU8A 4EGEA 1YVMA 2GG8A 1W2MA 2ZSGA 4ZWPA 1XNZA 1C22A 5JFRA 4Z7MA 3FMQA 2V3XA 4ZNGA 4FLKA 2GGCA 1WN1A 2IW2A 2EVCA 4U6CA 2GG5A 4RZZA 4R60A 2GG9A 1YW8A 2BHCA 2G6PA 3BIPA 1KP0A 1QXZA 5D6FA 1XGNA 3FM3A 4RGZ1 3S6BA 2DFIA 3PKEA 2OKNA 2GU4A 2Q92A 2BWVA 1WL9A 3L24A 2BHAA 1C24A 1WL6A 4FKCA 4KM3A 2B3KA 1WLRA 1XGMA 1PV9A 4PV4A 2Q95A 5CDVA 2GG7A 2BWSA 2B3LA 2BB7A 4ZWUA 5FCHA 1MATA 1R58A 1QXYA 2BWUA 1QXWA 2EVOA 3TB5A 5CLSA 4FLIA 5CNXA 2GG2A 1N51A 3PKCA 3CB5A 3RORA 1WY2A 5JHUA 4U70A 4RZYA 1C27A 1C21A 2V3YA 5CDEA 2BWXA 4A6WA 1B6AA 4S01A 5D6EA 4U76A 4FUKA 2GG0A 4QR8A 2P98A 1WBQA 1O0XA 2P9AA 4PNCA 2NQ7A 1KQ0A 2GU5A 3FMRA 4FLJA 1QZYA 4U6EA 2GU7A 4U73A 2P99A 2NQ6A 4IKTA 2GGBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U6Z A;  2EA2 A;  1Y1N A;  1JAW A;  4IPA A;  4ZWO A;  1BN5 A;  5CDL A;  4S00 A;  4U6J A;  3RVA A;  1B59 A;  3D27 A;  4FLL A;  3MX6 A;  1M35 A;  2Q94 A;  2GZ5 A;  1YW7 A;  2GG3 A;  1R5G A;  3TAV A;  1KQ9 A;  3IU7 A;  4U69 A;  2GTX A;  3BIQ A;  2BN7 A;  3CB6 A;  4IKR A;  3PKB A;  3MR1 A;  4A6V A;  2BWY A;  3L7G A;  3MAT A;  4U75 A;  5FCF A;  3IG4 A;  2BWT A;  2BHD A;  4IDY A;  5CE6 A;  1WKM A;  4IU6 A;  2BWW A;  1YJ3 A;  3PKA A;  4U1B A;  1XGO A;  4IKS A;  4JUQ A;  4S2R P;  2GA2 A;  2Q93 A;  3IU9 A;  1A16 A;  4OOK A;  2MAT A;  2GU6 A;  4IF7 A;  2HOW A;  5E5B A;  5JI6 A;  3CTZ A;  2EVM A;  2Q8K A;  2V3Z A;  2B3H A;  2V6C A;  4FO7 A;  4S2T P;  3PKD A;  1R5H A;  2ADU A;  2EA4 A;  3Q6D A;  1CHM A;  2Q96 A;  4HXX A;  1C23 A;  4MAT A;  5CIK A;  1XGS A;  4U71 A;  4IEC A;  4B28 A;  1W7V A;  1YW9 A;  4IKU A;  2BH3 A;  4FO8 A;  2BHB A;  2OAZ A;  3BIT A;  1BOA A;  4U6W A;  3IU8 A;  4EGE A;  1YVM A;  2GG8 A;  1W2M A;  2ZSG A;  4ZWP A;  1XNZ A;  1C22 A;  5JFR A;  4Z7M A;  3FMQ A;  2V3X A;  4ZNG A;  4FLK A;  2GGC A;  1WN1 A;  2IW2 A;  2EVC A;  4U6C A;  2GG5 A;  4RZZ A;  4R60 A;  2GG9 A;  1YW8 A;  2BHC A;  2G6P A;  3BIP A;  1KP0 A;  1QXZ A;  5D6F A;  1XGN A;  3FM3 A;  4RGZ 1;  3S6B A;  2DFI A;  3PKE A;  2OKN A;  2GU4 A;  2Q92 A;  2BWV A;  1WL9 A;  3L24 A;  2BHA A;  1C24 A;  1WL6 A;  4FKC A;  4KM3 A;  2B3K A;  1WLR A;  1XGM A;  1PV9 A;  4PV4 A;  2Q95 A;  5CDV A;  2GG7 A;  2BWS A;  2B3L A;  2BB7 A;  4ZWU A;  5FCH A;  1MAT A;  1R58 A;  1QXY A;  2BWU A;  1QXW A;  2EVO A;  3TB5 A;  5CLS A;  4FLI A;  5CNX A;  2GG2 A;  1N51 A;  3PKC A;  3CB5 A;  3ROR A;  1WY2 A;  5JHU A;  4U70 A;  4RZY A;  1C27 A;  1C21 A;  2V3Y A;  5CDE A;  2BWX A;  4A6W A;  1B6A A;  4S01 A;  5D6E A;  4U76 A;  4FUK A;  2GG0 A;  4QR8 A;  2P98 A;  1WBQ A;  1O0X A;  2P9A A;  4PNC A;  2NQ7 A;  1KQ0 A;  2GU5 A;  3FMR A;  4FLJ A;  1QZY A;  4U6E A;  2GU7 A;  4U73 A;  2P99 A;  2NQ6 A;  4IKT A;  2GGB A; 
#chains in the Genus database with same CATH topology
 4U6Z A;  2EA2 A;  1Y1N A;  1JAW A;  4IPA A;  4ZWO A;  1BN5 A;  5CDL A;  4S00 A;  4U6J A;  3RVA A;  1B59 A;  3D27 A;  4FLL A;  3MX6 A;  1M35 A;  2Q94 A;  2GZ5 A;  1YW7 A;  2GG3 A;  1R5G A;  3TAV A;  1KQ9 A;  3IU7 A;  4U69 A;  2GTX A;  3BIQ A;  2BN7 A;  3CB6 A;  4IKR A;  3PKB A;  3MR1 A;  4A6V A;  2BWY A;  3L7G A;  3MAT A;  4U75 A;  5FCF A;  3IG4 A;  2BWT A;  2BHD A;  4IDY A;  5CE6 A;  1WKM A;  4IU6 A;  2BWW A;  1YJ3 A;  3PKA A;  4U1B A;  1XGO A;  4IKS A;  4JUQ A;  4S2R P;  2GA2 A;  2Q93 A;  3IU9 A;  1A16 A;  4OOK A;  2MAT A;  2GU6 A;  4IF7 A;  2HOW A;  5E5B A;  5JI6 A;  3CTZ A;  2EVM A;  2Q8K A;  2V3Z A;  2B3H A;  2V6C A;  4FO7 A;  4S2T P;  3PKD A;  1R5H A;  2ADU A;  2EA4 A;  3Q6D A;  1CHM A;  2Q96 A;  4HXX A;  1C23 A;  4MAT A;  5CIK A;  1XGS A;  4U71 A;  4IEC A;  4B28 A;  1W7V A;  1YW9 A;  4IKU A;  2BH3 A;  4FO8 A;  2BHB A;  2OAZ A;  3BIT A;  1BOA A;  4U6W A;  3IU8 A;  4EGE A;  1YVM A;  2GG8 A;  1W2M A;  2ZSG A;  4ZWP A;  1XNZ A;  1C22 A;  5JFR A;  4Z7M A;  3FMQ A;  2V3X A;  4ZNG A;  4FLK A;  2GGC A;  1WN1 A;  2IW2 A;  2EVC A;  4U6C A;  2GG5 A;  4RZZ A;  4R60 A;  2GG9 A;  1YW8 A;  2BHC A;  2G6P A;  3BIP A;  1KP0 A;  1QXZ A;  5D6F A;  1XGN A;  3FM3 A;  4RGZ 1;  3S6B A;  2DFI A;  3PKE A;  2OKN A;  2GU4 A;  2Q92 A;  2BWV A;  1WL9 A;  3L24 A;  2BHA A;  1C24 A;  1WL6 A;  4FKC A;  4KM3 A;  2B3K A;  1WLR A;  1XGM A;  1PV9 A;  4PV4 A;  2Q95 A;  5CDV A;  2GG7 A;  2BWS A;  2B3L A;  2BB7 A;  4ZWU A;  5FCH A;  1MAT A;  1R58 A;  1QXY A;  2BWU A;  1QXW A;  2EVO A;  3TB5 A;  5CLS A;  4FLI A;  5CNX A;  2GG2 A;  1N51 A;  3PKC A;  3CB5 A;  3ROR A;  1WY2 A;  5JHU A;  4U70 A;  4RZY A;  1C27 A;  1C21 A;  2V3Y A;  5CDE A;  2BWX A;  4A6W A;  1B6A A;  4S01 A;  5D6E A;  4U76 A;  4FUK A;  2GG0 A;  4QR8 A;  2P98 A;  1WBQ A;  1O0X A;  2P9A A;  4PNC A;  2NQ7 A;  1KQ0 A;  2GU5 A;  3FMR A;  4FLJ A;  1QZY A;  4U6E A;  2GU7 A;  4U73 A;  2P99 A;  2NQ6 A;  4IKT A;  2GGB A; 
#chains in the Genus database with same CATH homology
 4U6Z A;  2EA2 A;  1Y1N A;  1JAW A;  4IPA A;  4ZWO A;  1BN5 A;  5CDL A;  4S00 A;  4U6J A;  3RVA A;  1B59 A;  3D27 A;  4FLL A;  3MX6 A;  1M35 A;  2Q94 A;  2GZ5 A;  1YW7 A;  2GG3 A;  1R5G A;  3TAV A;  1KQ9 A;  3IU7 A;  4U69 A;  2GTX A;  3BIQ A;  2BN7 A;  3CB6 A;  4IKR A;  3PKB A;  3MR1 A;  4A6V A;  2BWY A;  3L7G A;  3MAT A;  4U75 A;  5FCF A;  3IG4 A;  2BWT A;  2BHD A;  4IDY A;  5CE6 A;  1WKM A;  4IU6 A;  2BWW A;  1YJ3 A;  3PKA A;  4U1B A;  1XGO A;  4IKS A;  4JUQ A;  4S2R P;  2GA2 A;  2Q93 A;  3IU9 A;  1A16 A;  4OOK A;  2MAT A;  2GU6 A;  4IF7 A;  2HOW A;  5E5B A;  5JI6 A;  3CTZ A;  2EVM A;  2Q8K A;  2V3Z A;  2B3H A;  2V6C A;  4FO7 A;  4S2T P;  3PKD A;  1R5H A;  2ADU A;  2EA4 A;  3Q6D A;  1CHM A;  2Q96 A;  4HXX A;  1C23 A;  4MAT A;  5CIK A;  1XGS A;  4U71 A;  4IEC A;  4B28 A;  1W7V A;  1YW9 A;  4IKU A;  2BH3 A;  4FO8 A;  2BHB A;  2OAZ A;  3BIT A;  1BOA A;  4U6W A;  3IU8 A;  4EGE A;  1YVM A;  2GG8 A;  1W2M A;  2ZSG A;  4ZWP A;  1XNZ A;  1C22 A;  5JFR A;  4Z7M A;  3FMQ A;  2V3X A;  4ZNG A;  4FLK A;  2GGC A;  1WN1 A;  2IW2 A;  2EVC A;  4U6C A;  2GG5 A;  4RZZ A;  4R60 A;  2GG9 A;  1YW8 A;  2BHC A;  2G6P A;  3BIP A;  1KP0 A;  1QXZ A;  5D6F A;  1XGN A;  3FM3 A;  4RGZ 1;  3S6B A;  2DFI A;  3PKE A;  2OKN A;  2GU4 A;  2Q92 A;  2BWV A;  1WL9 A;  3L24 A;  2BHA A;  1C24 A;  1WL6 A;  4FKC A;  4KM3 A;  2B3K A;  1WLR A;  1XGM A;  1PV9 A;  4PV4 A;  2Q95 A;  5CDV A;  2GG7 A;  2BWS A;  2B3L A;  2BB7 A;  4ZWU A;  5FCH A;  1MAT A;  1R58 A;  1QXY A;  2BWU A;  1QXW A;  2EVO A;  3TB5 A;  5CLS A;  4FLI A;  5CNX A;  2GG2 A;  1N51 A;  3PKC A;  3CB5 A;  3ROR A;  1WY2 A;  5JHU A;  4U70 A;  4RZY A;  1C27 A;  1C21 A;  2V3Y A;  5CDE A;  2BWX A;  4A6W A;  1B6A A;  4S01 A;  5D6E A;  4U76 A;  4FUK A;  2GG0 A;  4QR8 A;  2P98 A;  1WBQ A;  1O0X A;  2P9A A;  4PNC A;  2NQ7 A;  1KQ0 A;  2GU5 A;  3FMR A;  4FLJ A;  1QZY A;  4U6E A;  2GU7 A;  4U73 A;  2P99 A;  2NQ6 A;  4IKT A;  2GGB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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