4OOKA

Third metal bound m.tuberculosis methionine aminopeptidase
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
282
structure length
282
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 2
total genus 88
structure length 282
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4ookA01
1BOAA 2GU4A 5CDEA 1R5GA 1YVMA 1C27A 2NQ6A 4RZZA 4B28A 4U6ZA 4ZNGA 5D6EA 4IU6A 1XGOA 4HXXA 3IU7A 5FCFA 1B6AA 4FLIA 4S01A 2V6CA 4U70A 2GG2A 4ZWOA 4IKRA 4IPAA 4S00A 1C22A 1YJ3A 2P99A 3PKEA 1YW9A 2GG3A 2EVOA 1PV9A 3PKAA 2GG7A 4ZWPA 4S2TP 5CE6A 5JHUA 4U1BA 1KQ0A 2BHCA 1B59A 3BIPA 1WBQA 2BWYA 2MATA 3L7GA 4U6CA 3IU8A 3MX6A 4Z7MA 2NQ7A 1A16A 2Q8KA 4QR8A 1JAWA 4FUKA 3TAVA 4A6VA 2BWUA 3BITA 1R58A 5CDLA 2GU6A 2BWWA 1QXZA 4KM3A 1YW8A 4MATA 2EVCA 2GG9A 1C21A 2BN7A 2HOWA 5CDVA 4ZWUA 1WL6A 1N51A 2GGBA 3TB5A 2V3ZA 3MR1A 2GGCA 3PKDA 4IDYA 5CNXA 5CIKA 3RORA 4IKSA 3IG4A 2EVMA 4U6EA 3D27A 4OOKA 2BWTA 2GG5A 4A6WA 1W7VA 1XNZA 2OKNA 2BHDA 1C24A 1BN5A 2OAZA 2BHAA 4FKCA 4JUQA 2Q95A 1KP0A 2Q93A 5FCHA 2BWSA 3IU9A 5CLSA 1M35A 5JFRA 4U75A 3CB6A 2B3LA 3BIQA 4U69A 4FLJA 3PKCA 2GA2A 1W2MA 2P9AA 2Q94A 3L24A 1XGSA 2GU7A 3FMQA 3CTZA 4FLKA 4FO8A 4RGZ1 4S2RP 4U6WA 2BB7A 3S6BA 2V3XA 4R60A 3Q6DA 4U73A 4EGEA 1CHMA 4U71A 2V3YA 4FLLA 3RVAA 1WLRA 1O0XA 1XGMA 1YW7A 1KQ9A 4U76A 2G6PA 4U6JA 1MATA 2EA2A 2B3HA 2GZ5A 1QXYA 1WN1A 2Q92A 3MATA 1XGNA 2P98A 2IW2A 1C23A 5E5BA 2BHBA 3CB5A 2BWXA 5JI6A 2GG8A 2B3KA 3PKBA 4FO7A 1WY2A 2BH3A 1Y1NA 4PV4A 2GU5A 4RZYA 4IKUA 1R5HA 1WL9A 1QZYA 4IECA 2EA4A 2Q96A 4IF7A 1QXWA 3FM3A 2GG0A 3FMRA 2ZSGA 2ADUA 4IKTA 5D6FA 2DFIA 2GTXA 4PNCA 2BWVA 1WKMA
chains in the Genus database with same CATH superfamily
1BOAA 2GU4A 5CDEA 1R5GA 1YVMA 1C27A 2NQ6A 4RZZA 4B28A 4U6ZA 4ZNGA 5D6EA 4IU6A 1XGOA 4HXXA 3IU7A 5FCFA 1B6AA 4FLIA 4S01A 2V6CA 4U70A 2GG2A 4ZWOA 4IKRA 4IPAA 4S00A 1C22A 1YJ3A 2P99A 3PKEA 1YW9A 2GG3A 2EVOA 1PV9A 3PKAA 2GG7A 4ZWPA 4S2TP 5CE6A 5JHUA 4U1BA 1KQ0A 2BHCA 1B59A 3BIPA 1WBQA 2BWYA 2MATA 3L7GA 4U6CA 3IU8A 3MX6A 4Z7MA 2NQ7A 1A16A 2Q8KA 4QR8A 1JAWA 4FUKA 3TAVA 4A6VA 2BWUA 3BITA 1R58A 5CDLA 2GU6A 2BWWA 1QXZA 4KM3A 1YW8A 4MATA 2EVCA 2GG9A 1C21A 2BN7A 2HOWA 5CDVA 4ZWUA 1WL6A 1N51A 2GGBA 3TB5A 2V3ZA 3MR1A 2GGCA 3PKDA 4IDYA 5CNXA 5CIKA 3RORA 4IKSA 3IG4A 2EVMA 4U6EA 3D27A 4OOKA 2BWTA 2GG5A 4A6WA 1W7VA 1XNZA 2OKNA 2BHDA 1C24A 1BN5A 2OAZA 2BHAA 4FKCA 4JUQA 2Q95A 1KP0A 2Q93A 5FCHA 2BWSA 3IU9A 5CLSA 1M35A 5JFRA 4U75A 3CB6A 2B3LA 3BIQA 4U69A 4FLJA 3PKCA 2GA2A 1W2MA 2P9AA 2Q94A 3L24A 1XGSA 2GU7A 3FMQA 3CTZA 4FLKA 4FO8A 4RGZ1 4S2RP 4U6WA 2BB7A 3S6BA 2V3XA 4R60A 3Q6DA 4U73A 4EGEA 1CHMA 4U71A 2V3YA 4FLLA 3RVAA 1WLRA 1O0XA 1XGMA 1YW7A 1KQ9A 4U76A 2G6PA 4U6JA 1MATA 2EA2A 2B3HA 2GZ5A 1QXYA 1WN1A 2Q92A 3MATA 1XGNA 2P98A 2IW2A 1C23A 5E5BA 2BHBA 3CB5A 2BWXA 5JI6A 2GG8A 2B3KA 3PKBA 4FO7A 1WY2A 2BH3A 1Y1NA 4PV4A 2GU5A 4RZYA 4IKUA 1R5HA 1WL9A 1QZYA 4IECA 2EA4A 2Q96A 4IF7A 1QXWA 3FM3A 2GG0A 3FMRA 2ZSGA 2ADUA 4IKTA 5D6FA 2DFIA 2GTXA 4PNCA 2BWVA 1WKMA
chains in the Genus database with same CATH topology
1BOAA 2GU4A 5CDEA 1R5GA 1YVMA 1C27A 2NQ6A 4RZZA 4B28A 4U6ZA 4ZNGA 5D6EA 4IU6A 1XGOA 4HXXA 3IU7A 5FCFA 1B6AA 4FLIA 4S01A 2V6CA 4U70A 2GG2A 4ZWOA 4IKRA 4IPAA 4S00A 1C22A 1YJ3A 2P99A 3PKEA 1YW9A 2GG3A 2EVOA 1PV9A 3PKAA 2GG7A 4ZWPA 4S2TP 5CE6A 5JHUA 4U1BA 1KQ0A 2BHCA 1B59A 3BIPA 1WBQA 2BWYA 2MATA 3L7GA 4U6CA 3IU8A 3MX6A 4Z7MA 2NQ7A 1A16A 2Q8KA 4QR8A 1JAWA 4FUKA 3TAVA 4A6VA 2BWUA 3BITA 1R58A 5CDLA 2GU6A 2BWWA 1QXZA 4KM3A 1YW8A 4MATA 2EVCA 2GG9A 1C21A 2BN7A 2HOWA 5CDVA 4ZWUA 1WL6A 1N51A 2GGBA 3TB5A 2V3ZA 3MR1A 2GGCA 3PKDA 4IDYA 5CNXA 5CIKA 3RORA 4IKSA 3IG4A 2EVMA 4U6EA 3D27A 4OOKA 2BWTA 2GG5A 4A6WA 1W7VA 1XNZA 2OKNA 2BHDA 1C24A 1BN5A 2OAZA 2BHAA 4FKCA 4JUQA 2Q95A 1KP0A 2Q93A 5FCHA 2BWSA 3IU9A 5CLSA 1M35A 5JFRA 4U75A 3CB6A 2B3LA 3BIQA 4U69A 4FLJA 3PKCA 2GA2A 1W2MA 2P9AA 2Q94A 3L24A 1XGSA 2GU7A 3FMQA 3CTZA 4FLKA 4FO8A 4RGZ1 4S2RP 4U6WA 2BB7A 3S6BA 2V3XA 4R60A 3Q6DA 4U73A 4EGEA 1CHMA 4U71A 2V3YA 4FLLA 3RVAA 1WLRA 1O0XA 1XGMA 1YW7A 1KQ9A 4U76A 2G6PA 4U6JA 1MATA 2EA2A 2B3HA 2GZ5A 1QXYA 1WN1A 2Q92A 3MATA 1XGNA 2P98A 2IW2A 1C23A 5E5BA 2BHBA 3CB5A 2BWXA 5JI6A 2GG8A 2B3KA 3PKBA 4FO7A 1WY2A 2BH3A 1Y1NA 4PV4A 2GU5A 4RZYA 4IKUA 1R5HA 1WL9A 1QZYA 4IECA 2EA4A 2Q96A 4IF7A 1QXWA 3FM3A 2GG0A 3FMRA 2ZSGA 2ADUA 4IKTA 5D6FA 2DFIA 2GTXA 4PNCA 2BWVA 1WKMA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1BOA A;  2GU4 A;  5CDE A;  1R5G A;  1YVM A;  1C27 A;  2NQ6 A;  4RZZ A;  4B28 A;  4U6Z A;  4ZNG A;  5D6E A;  4IU6 A;  1XGO A;  4HXX A;  3IU7 A;  5FCF A;  1B6A A;  4FLI A;  4S01 A;  2V6C A;  4U70 A;  2GG2 A;  4ZWO A;  4IKR A;  4IPA A;  4S00 A;  1C22 A;  1YJ3 A;  2P99 A;  3PKE A;  1YW9 A;  2GG3 A;  2EVO A;  1PV9 A;  3PKA A;  2GG7 A;  4ZWP A;  4S2T P;  5CE6 A;  5JHU A;  4U1B A;  1KQ0 A;  2BHC A;  1B59 A;  3BIP A;  1WBQ A;  2BWY A;  2MAT A;  3L7G A;  4U6C A;  3IU8 A;  3MX6 A;  4Z7M A;  2NQ7 A;  1A16 A;  2Q8K A;  4QR8 A;  1JAW A;  4FUK A;  3TAV A;  4A6V A;  2BWU A;  3BIT A;  1R58 A;  5CDL A;  2GU6 A;  2BWW A;  1QXZ A;  4KM3 A;  1YW8 A;  4MAT A;  2EVC A;  2GG9 A;  1C21 A;  2BN7 A;  2HOW A;  5CDV A;  4ZWU A;  1WL6 A;  1N51 A;  2GGB A;  3TB5 A;  2V3Z A;  3MR1 A;  2GGC A;  3PKD A;  4IDY A;  5CNX A;  5CIK A;  3ROR A;  4IKS A;  3IG4 A;  2EVM A;  4U6E A;  3D27 A;  4OOK A;  2BWT A;  2GG5 A;  4A6W A;  1W7V A;  1XNZ A;  2OKN A;  2BHD A;  1C24 A;  1BN5 A;  2OAZ A;  2BHA A;  4FKC A;  4JUQ A;  2Q95 A;  1KP0 A;  2Q93 A;  5FCH A;  2BWS A;  3IU9 A;  5CLS A;  1M35 A;  5JFR A;  4U75 A;  3CB6 A;  2B3L A;  3BIQ A;  4U69 A;  4FLJ A;  3PKC A;  2GA2 A;  1W2M A;  2P9A A;  2Q94 A;  3L24 A;  1XGS A;  2GU7 A;  3FMQ A;  3CTZ A;  4FLK A;  4FO8 A;  4RGZ 1;  4S2R P;  4U6W A;  2BB7 A;  3S6B A;  2V3X A;  4R60 A;  3Q6D A;  4U73 A;  4EGE A;  1CHM A;  4U71 A;  2V3Y A;  4FLL A;  3RVA A;  1WLR A;  1O0X A;  1XGM A;  1YW7 A;  1KQ9 A;  4U76 A;  2G6P A;  4U6J A;  1MAT A;  2EA2 A;  2B3H A;  2GZ5 A;  1QXY A;  1WN1 A;  2Q92 A;  3MAT A;  1XGN A;  2P98 A;  2IW2 A;  1C23 A;  5E5B A;  2BHB A;  3CB5 A;  2BWX A;  5JI6 A;  2GG8 A;  2B3K A;  3PKB A;  4FO7 A;  1WY2 A;  2BH3 A;  1Y1N A;  4PV4 A;  2GU5 A;  4RZY A;  4IKU A;  1R5H A;  1WL9 A;  1QZY A;  4IEC A;  2EA4 A;  2Q96 A;  4IF7 A;  1QXW A;  3FM3 A;  2GG0 A;  3FMR A;  2ZSG A;  2ADU A;  4IKT A;  5D6F A;  2DFI A;  2GTX A;  4PNC A;  2BWV A;  1WKM A; 
#chains in the Genus database with same CATH topology
 1BOA A;  2GU4 A;  5CDE A;  1R5G A;  1YVM A;  1C27 A;  2NQ6 A;  4RZZ A;  4B28 A;  4U6Z A;  4ZNG A;  5D6E A;  4IU6 A;  1XGO A;  4HXX A;  3IU7 A;  5FCF A;  1B6A A;  4FLI A;  4S01 A;  2V6C A;  4U70 A;  2GG2 A;  4ZWO A;  4IKR A;  4IPA A;  4S00 A;  1C22 A;  1YJ3 A;  2P99 A;  3PKE A;  1YW9 A;  2GG3 A;  2EVO A;  1PV9 A;  3PKA A;  2GG7 A;  4ZWP A;  4S2T P;  5CE6 A;  5JHU A;  4U1B A;  1KQ0 A;  2BHC A;  1B59 A;  3BIP A;  1WBQ A;  2BWY A;  2MAT A;  3L7G A;  4U6C A;  3IU8 A;  3MX6 A;  4Z7M A;  2NQ7 A;  1A16 A;  2Q8K A;  4QR8 A;  1JAW A;  4FUK A;  3TAV A;  4A6V A;  2BWU A;  3BIT A;  1R58 A;  5CDL A;  2GU6 A;  2BWW A;  1QXZ A;  4KM3 A;  1YW8 A;  4MAT A;  2EVC A;  2GG9 A;  1C21 A;  2BN7 A;  2HOW A;  5CDV A;  4ZWU A;  1WL6 A;  1N51 A;  2GGB A;  3TB5 A;  2V3Z A;  3MR1 A;  2GGC A;  3PKD A;  4IDY A;  5CNX A;  5CIK A;  3ROR A;  4IKS A;  3IG4 A;  2EVM A;  4U6E A;  3D27 A;  4OOK A;  2BWT A;  2GG5 A;  4A6W A;  1W7V A;  1XNZ A;  2OKN A;  2BHD A;  1C24 A;  1BN5 A;  2OAZ A;  2BHA A;  4FKC A;  4JUQ A;  2Q95 A;  1KP0 A;  2Q93 A;  5FCH A;  2BWS A;  3IU9 A;  5CLS A;  1M35 A;  5JFR A;  4U75 A;  3CB6 A;  2B3L A;  3BIQ A;  4U69 A;  4FLJ A;  3PKC A;  2GA2 A;  1W2M A;  2P9A A;  2Q94 A;  3L24 A;  1XGS A;  2GU7 A;  3FMQ A;  3CTZ A;  4FLK A;  4FO8 A;  4RGZ 1;  4S2R P;  4U6W A;  2BB7 A;  3S6B A;  2V3X A;  4R60 A;  3Q6D A;  4U73 A;  4EGE A;  1CHM A;  4U71 A;  2V3Y A;  4FLL A;  3RVA A;  1WLR A;  1O0X A;  1XGM A;  1YW7 A;  1KQ9 A;  4U76 A;  2G6P A;  4U6J A;  1MAT A;  2EA2 A;  2B3H A;  2GZ5 A;  1QXY A;  1WN1 A;  2Q92 A;  3MAT A;  1XGN A;  2P98 A;  2IW2 A;  1C23 A;  5E5B A;  2BHB A;  3CB5 A;  2BWX A;  5JI6 A;  2GG8 A;  2B3K A;  3PKB A;  4FO7 A;  1WY2 A;  2BH3 A;  1Y1N A;  4PV4 A;  2GU5 A;  4RZY A;  4IKU A;  1R5H A;  1WL9 A;  1QZY A;  4IEC A;  2EA4 A;  2Q96 A;  4IF7 A;  1QXW A;  3FM3 A;  2GG0 A;  3FMR A;  2ZSG A;  2ADU A;  4IKT A;  5D6F A;  2DFI A;  2GTX A;  4PNC A;  2BWV A;  1WKM A; 
#chains in the Genus database with same CATH homology
 1BOA A;  2GU4 A;  5CDE A;  1R5G A;  1YVM A;  1C27 A;  2NQ6 A;  4RZZ A;  4B28 A;  4U6Z A;  4ZNG A;  5D6E A;  4IU6 A;  1XGO A;  4HXX A;  3IU7 A;  5FCF A;  1B6A A;  4FLI A;  4S01 A;  2V6C A;  4U70 A;  2GG2 A;  4ZWO A;  4IKR A;  4IPA A;  4S00 A;  1C22 A;  1YJ3 A;  2P99 A;  3PKE A;  1YW9 A;  2GG3 A;  2EVO A;  1PV9 A;  3PKA A;  2GG7 A;  4ZWP A;  4S2T P;  5CE6 A;  5JHU A;  4U1B A;  1KQ0 A;  2BHC A;  1B59 A;  3BIP A;  1WBQ A;  2BWY A;  2MAT A;  3L7G A;  4U6C A;  3IU8 A;  3MX6 A;  4Z7M A;  2NQ7 A;  1A16 A;  2Q8K A;  4QR8 A;  1JAW A;  4FUK A;  3TAV A;  4A6V A;  2BWU A;  3BIT A;  1R58 A;  5CDL A;  2GU6 A;  2BWW A;  1QXZ A;  4KM3 A;  1YW8 A;  4MAT A;  2EVC A;  2GG9 A;  1C21 A;  2BN7 A;  2HOW A;  5CDV A;  4ZWU A;  1WL6 A;  1N51 A;  2GGB A;  3TB5 A;  2V3Z A;  3MR1 A;  2GGC A;  3PKD A;  4IDY A;  5CNX A;  5CIK A;  3ROR A;  4IKS A;  3IG4 A;  2EVM A;  4U6E A;  3D27 A;  4OOK A;  2BWT A;  2GG5 A;  4A6W A;  1W7V A;  1XNZ A;  2OKN A;  2BHD A;  1C24 A;  1BN5 A;  2OAZ A;  2BHA A;  4FKC A;  4JUQ A;  2Q95 A;  1KP0 A;  2Q93 A;  5FCH A;  2BWS A;  3IU9 A;  5CLS A;  1M35 A;  5JFR A;  4U75 A;  3CB6 A;  2B3L A;  3BIQ A;  4U69 A;  4FLJ A;  3PKC A;  2GA2 A;  1W2M A;  2P9A A;  2Q94 A;  3L24 A;  1XGS A;  2GU7 A;  3FMQ A;  3CTZ A;  4FLK A;  4FO8 A;  4RGZ 1;  4S2R P;  4U6W A;  2BB7 A;  3S6B A;  2V3X A;  4R60 A;  3Q6D A;  4U73 A;  4EGE A;  1CHM A;  4U71 A;  2V3Y A;  4FLL A;  3RVA A;  1WLR A;  1O0X A;  1XGM A;  1YW7 A;  1KQ9 A;  4U76 A;  2G6P A;  4U6J A;  1MAT A;  2EA2 A;  2B3H A;  2GZ5 A;  1QXY A;  1WN1 A;  2Q92 A;  3MAT A;  1XGN A;  2P98 A;  2IW2 A;  1C23 A;  5E5B A;  2BHB A;  3CB5 A;  2BWX A;  5JI6 A;  2GG8 A;  2B3K A;  3PKB A;  4FO7 A;  1WY2 A;  2BH3 A;  1Y1N A;  4PV4 A;  2GU5 A;  4RZY A;  4IKU A;  1R5H A;  1WL9 A;  1QZY A;  4IEC A;  2EA4 A;  2Q96 A;  4IF7 A;  1QXW A;  3FM3 A;  2GG0 A;  3FMR A;  2ZSG A;  2ADU A;  4IKT A;  5D6F A;  2DFI A;  2GTX A;  4PNC A;  2BWV A;  1WKM A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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