4OOKA

Third metal bound m.tuberculosis methionine aminopeptidase
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
282
structure length
282
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule keywords Methionine aminopeptidase 2
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
source organism Mycobacterium tuberculosis
molecule tags Hydrolase
total genus 88
structure length 282
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4ookA01
3MX6A 2B3KA 2Q93A 2OAZA 1W2MA 2P9AA 3PKEA 3IU8A 4IKRA 4S2TP 4JUQA 2GG0A 2Q95A 1CHMA 1R5HA 5CE6A 2OKNA 3FMQA 4RZYA 2Q96A 3L7GA 1YW9A 4U1BA 5JI6A 2ZSGA 2P98A 5CDLA 2BHBA 2GTXA 1XGOA 4RZZA 2B3HA 2GG8A 4S00A 5CNXA 4FO7A 4IF7A 3IU9A 2GA2A 2EA2A 4FLKA 3CB6A 1WKMA 5D6FA 2BHCA 3PKDA 3TB5A 2EA4A 2B3LA 2V3ZA 2BWWA 1B59A 2GU6A 1W7VA 2EVMA 5CIKA 3CB5A 2NQ6A 4KM3A 3FM3A 3MATA 4FLIA 1WLRA 2Q8KA 1R5GA 4S01A 4HXXA 4Z7MA 2DFIA 1YW8A 4PV4A 2EVCA 5FCHA 4ZWPA 2GU7A 4QR8A 2GU5A 4ZWUA 2IW2A 1YJ3A 2Q94A 5FCFA 2GG9A 2GGCA 3Q6DA 4FLLA 1QXZA 4FO8A 5E5BA 3CTZA 1WL9A 4U75A 2MATA 4B28A 2BWUA 1WBQA 2V3YA 3MR1A 2GU4A 5D6EA 1YVMA 4R60A 4RGZ1 4ZNGA 1KQ0A 2BWYA 3FMRA 3PKAA 4IKUA 4IKTA 2NQ7A 5CLSA 3S6BA 2BHDA 1Y1NA 3PKCA 4U69A 1C22A 1PV9A 1QXYA 2BWXA 4U6JA 1R58A 1XGMA 4FLJA 3BIQA 4U70A 4EGEA 1BOAA 2EVOA 2Q92A 3BITA 2GG5A 5CDVA 4U73A 1WL6A 1C24A 3PKBA 4U76A 4A6WA 4IKSA 1C23A 4U6WA 3IG4A 2ADUA 4U6EA 1BN5A 2GGBA 4FKCA 1O0XA 2V3XA 3L24A 2BB7A 4FUKA 4IPAA 1B6AA 1WN1A 1KP0A 2BN7A 2BWSA 4MATA 2GG7A 3TAVA 1KQ9A 1C21A 4IDYA 1QZYA 3RVAA 4IECA 4U71A 2BWTA 1N51A 1XGNA 1YW7A 5JHUA 5CDEA 1XNZA 4IU6A 3BIPA 1A16A 1QXWA 4S2RP 2GZ5A 1WY2A 3D27A 5JFRA 1XGSA 4PNCA 4A6VA 2GG2A 2G6PA 3RORA 1C27A 2P99A 1MATA 4ZWOA 2V6CA 2BH3A 2GG3A 4U6CA 4U6ZA 2BWVA 1JAWA 2BHAA 3IU7A 4OOKA 2HOWA 1M35A
chains in the Genus database with same CATH superfamily
3MX6A 2B3KA 2Q93A 2OAZA 1W2MA 2P9AA 3PKEA 3IU8A 4IKRA 4S2TP 4JUQA 2GG0A 2Q95A 1CHMA 1R5HA 5CE6A 2OKNA 3FMQA 4RZYA 2Q96A 3L7GA 1YW9A 4U1BA 5JI6A 2ZSGA 2P98A 5CDLA 2BHBA 2GTXA 1XGOA 4RZZA 2B3HA 2GG8A 4S00A 5CNXA 4FO7A 4IF7A 3IU9A 2GA2A 2EA2A 4FLKA 3CB6A 1WKMA 5D6FA 2BHCA 3PKDA 3TB5A 2EA4A 2B3LA 2V3ZA 2BWWA 1B59A 2GU6A 1W7VA 2EVMA 5CIKA 3CB5A 2NQ6A 4KM3A 3FM3A 3MATA 4FLIA 1WLRA 2Q8KA 1R5GA 4S01A 4HXXA 4Z7MA 2DFIA 1YW8A 4PV4A 2EVCA 5FCHA 4ZWPA 2GU7A 4QR8A 2GU5A 4ZWUA 2IW2A 1YJ3A 2Q94A 5FCFA 2GG9A 2GGCA 3Q6DA 4FLLA 1QXZA 4FO8A 5E5BA 3CTZA 1WL9A 4U75A 2MATA 4B28A 2BWUA 1WBQA 2V3YA 3MR1A 2GU4A 5D6EA 1YVMA 4R60A 4RGZ1 4ZNGA 1KQ0A 2BWYA 3FMRA 3PKAA 4IKUA 4IKTA 2NQ7A 5CLSA 3S6BA 2BHDA 1Y1NA 3PKCA 4U69A 1C22A 1PV9A 1QXYA 2BWXA 4U6JA 1R58A 1XGMA 4FLJA 3BIQA 4U70A 4EGEA 1BOAA 2EVOA 2Q92A 3BITA 2GG5A 5CDVA 4U73A 1WL6A 1C24A 3PKBA 4U76A 4A6WA 4IKSA 1C23A 4U6WA 3IG4A 2ADUA 4U6EA 1BN5A 2GGBA 4FKCA 1O0XA 2V3XA 3L24A 2BB7A 4FUKA 4IPAA 1B6AA 1WN1A 1KP0A 2BN7A 2BWSA 4MATA 2GG7A 3TAVA 1KQ9A 1C21A 4IDYA 1QZYA 3RVAA 4IECA 4U71A 2BWTA 1N51A 1XGNA 1YW7A 5JHUA 5CDEA 1XNZA 4IU6A 3BIPA 1A16A 1QXWA 4S2RP 2GZ5A 1WY2A 3D27A 5JFRA 1XGSA 4PNCA 4A6VA 2GG2A 2G6PA 3RORA 1C27A 2P99A 1MATA 4ZWOA 2V6CA 2BH3A 2GG3A 4U6CA 4U6ZA 2BWVA 1JAWA 2BHAA 3IU7A 4OOKA 2HOWA 1M35A
chains in the Genus database with same CATH topology
3MX6A 2B3KA 2Q93A 2OAZA 1W2MA 2P9AA 3PKEA 3IU8A 4IKRA 4S2TP 4JUQA 2GG0A 2Q95A 1CHMA 1R5HA 5CE6A 2OKNA 3FMQA 4RZYA 2Q96A 3L7GA 1YW9A 4U1BA 5JI6A 2ZSGA 2P98A 5CDLA 2BHBA 2GTXA 1XGOA 4RZZA 2B3HA 2GG8A 4S00A 5CNXA 4FO7A 4IF7A 3IU9A 2GA2A 2EA2A 4FLKA 3CB6A 1WKMA 5D6FA 2BHCA 3PKDA 3TB5A 2EA4A 2B3LA 2V3ZA 2BWWA 1B59A 2GU6A 1W7VA 2EVMA 5CIKA 3CB5A 2NQ6A 4KM3A 3FM3A 3MATA 4FLIA 1WLRA 2Q8KA 1R5GA 4S01A 4HXXA 4Z7MA 2DFIA 1YW8A 4PV4A 2EVCA 5FCHA 4ZWPA 2GU7A 4QR8A 2GU5A 4ZWUA 2IW2A 1YJ3A 2Q94A 5FCFA 2GG9A 2GGCA 3Q6DA 4FLLA 1QXZA 4FO8A 5E5BA 3CTZA 1WL9A 4U75A 2MATA 4B28A 2BWUA 1WBQA 2V3YA 3MR1A 2GU4A 5D6EA 1YVMA 4R60A 4RGZ1 4ZNGA 1KQ0A 2BWYA 3FMRA 3PKAA 4IKUA 4IKTA 2NQ7A 5CLSA 3S6BA 2BHDA 1Y1NA 3PKCA 4U69A 1C22A 1PV9A 1QXYA 2BWXA 4U6JA 1R58A 1XGMA 4FLJA 3BIQA 4U70A 4EGEA 1BOAA 2EVOA 2Q92A 3BITA 2GG5A 5CDVA 4U73A 1WL6A 1C24A 3PKBA 4U76A 4A6WA 4IKSA 1C23A 4U6WA 3IG4A 2ADUA 4U6EA 1BN5A 2GGBA 4FKCA 1O0XA 2V3XA 3L24A 2BB7A 4FUKA 4IPAA 1B6AA 1WN1A 1KP0A 2BN7A 2BWSA 4MATA 2GG7A 3TAVA 1KQ9A 1C21A 4IDYA 1QZYA 3RVAA 4IECA 4U71A 2BWTA 1N51A 1XGNA 1YW7A 5JHUA 5CDEA 1XNZA 4IU6A 3BIPA 1A16A 1QXWA 4S2RP 2GZ5A 1WY2A 3D27A 5JFRA 1XGSA 4PNCA 4A6VA 2GG2A 2G6PA 3RORA 1C27A 2P99A 1MATA 4ZWOA 2V6CA 2BH3A 2GG3A 4U6CA 4U6ZA 2BWVA 1JAWA 2BHAA 3IU7A 4OOKA 2HOWA 1M35A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MX6 A;  2B3K A;  2Q93 A;  2OAZ A;  1W2M A;  2P9A A;  3PKE A;  3IU8 A;  4IKR A;  4S2T P;  4JUQ A;  2GG0 A;  2Q95 A;  1CHM A;  1R5H A;  5CE6 A;  2OKN A;  3FMQ A;  4RZY A;  2Q96 A;  3L7G A;  1YW9 A;  4U1B A;  5JI6 A;  2ZSG A;  2P98 A;  5CDL A;  2BHB A;  2GTX A;  1XGO A;  4RZZ A;  2B3H A;  2GG8 A;  4S00 A;  5CNX A;  4FO7 A;  4IF7 A;  3IU9 A;  2GA2 A;  2EA2 A;  4FLK A;  3CB6 A;  1WKM A;  5D6F A;  2BHC A;  3PKD A;  3TB5 A;  2EA4 A;  2B3L A;  2V3Z A;  2BWW A;  1B59 A;  2GU6 A;  1W7V A;  2EVM A;  5CIK A;  3CB5 A;  2NQ6 A;  4KM3 A;  3FM3 A;  3MAT A;  4FLI A;  1WLR A;  2Q8K A;  1R5G A;  4S01 A;  4HXX A;  4Z7M A;  2DFI A;  1YW8 A;  4PV4 A;  2EVC A;  5FCH A;  4ZWP A;  2GU7 A;  4QR8 A;  2GU5 A;  4ZWU A;  2IW2 A;  1YJ3 A;  2Q94 A;  5FCF A;  2GG9 A;  2GGC A;  3Q6D A;  4FLL A;  1QXZ A;  4FO8 A;  5E5B A;  3CTZ A;  1WL9 A;  4U75 A;  2MAT A;  4B28 A;  2BWU A;  1WBQ A;  2V3Y A;  3MR1 A;  2GU4 A;  5D6E A;  1YVM A;  4R60 A;  4RGZ 1;  4ZNG A;  1KQ0 A;  2BWY A;  3FMR A;  3PKA A;  4IKU A;  4IKT A;  2NQ7 A;  5CLS A;  3S6B A;  2BHD A;  1Y1N A;  3PKC A;  4U69 A;  1C22 A;  1PV9 A;  1QXY A;  2BWX A;  4U6J A;  1R58 A;  1XGM A;  4FLJ A;  3BIQ A;  4U70 A;  4EGE A;  1BOA A;  2EVO A;  2Q92 A;  3BIT A;  2GG5 A;  5CDV A;  4U73 A;  1WL6 A;  1C24 A;  3PKB A;  4U76 A;  4A6W A;  4IKS A;  1C23 A;  4U6W A;  3IG4 A;  2ADU A;  4U6E A;  1BN5 A;  2GGB A;  4FKC A;  1O0X A;  2V3X A;  3L24 A;  2BB7 A;  4FUK A;  4IPA A;  1B6A A;  1WN1 A;  1KP0 A;  2BN7 A;  2BWS A;  4MAT A;  2GG7 A;  3TAV A;  1KQ9 A;  1C21 A;  4IDY A;  1QZY A;  3RVA A;  4IEC A;  4U71 A;  2BWT A;  1N51 A;  1XGN A;  1YW7 A;  5JHU A;  5CDE A;  1XNZ A;  4IU6 A;  3BIP A;  1A16 A;  1QXW A;  4S2R P;  2GZ5 A;  1WY2 A;  3D27 A;  5JFR A;  1XGS A;  4PNC A;  4A6V A;  2GG2 A;  2G6P A;  3ROR A;  1C27 A;  2P99 A;  1MAT A;  4ZWO A;  2V6C A;  2BH3 A;  2GG3 A;  4U6C A;  4U6Z A;  2BWV A;  1JAW A;  2BHA A;  3IU7 A;  4OOK A;  2HOW A;  1M35 A; 
#chains in the Genus database with same CATH topology
 3MX6 A;  2B3K A;  2Q93 A;  2OAZ A;  1W2M A;  2P9A A;  3PKE A;  3IU8 A;  4IKR A;  4S2T P;  4JUQ A;  2GG0 A;  2Q95 A;  1CHM A;  1R5H A;  5CE6 A;  2OKN A;  3FMQ A;  4RZY A;  2Q96 A;  3L7G A;  1YW9 A;  4U1B A;  5JI6 A;  2ZSG A;  2P98 A;  5CDL A;  2BHB A;  2GTX A;  1XGO A;  4RZZ A;  2B3H A;  2GG8 A;  4S00 A;  5CNX A;  4FO7 A;  4IF7 A;  3IU9 A;  2GA2 A;  2EA2 A;  4FLK A;  3CB6 A;  1WKM A;  5D6F A;  2BHC A;  3PKD A;  3TB5 A;  2EA4 A;  2B3L A;  2V3Z A;  2BWW A;  1B59 A;  2GU6 A;  1W7V A;  2EVM A;  5CIK A;  3CB5 A;  2NQ6 A;  4KM3 A;  3FM3 A;  3MAT A;  4FLI A;  1WLR A;  2Q8K A;  1R5G A;  4S01 A;  4HXX A;  4Z7M A;  2DFI A;  1YW8 A;  4PV4 A;  2EVC A;  5FCH A;  4ZWP A;  2GU7 A;  4QR8 A;  2GU5 A;  4ZWU A;  2IW2 A;  1YJ3 A;  2Q94 A;  5FCF A;  2GG9 A;  2GGC A;  3Q6D A;  4FLL A;  1QXZ A;  4FO8 A;  5E5B A;  3CTZ A;  1WL9 A;  4U75 A;  2MAT A;  4B28 A;  2BWU A;  1WBQ A;  2V3Y A;  3MR1 A;  2GU4 A;  5D6E A;  1YVM A;  4R60 A;  4RGZ 1;  4ZNG A;  1KQ0 A;  2BWY A;  3FMR A;  3PKA A;  4IKU A;  4IKT A;  2NQ7 A;  5CLS A;  3S6B A;  2BHD A;  1Y1N A;  3PKC A;  4U69 A;  1C22 A;  1PV9 A;  1QXY A;  2BWX A;  4U6J A;  1R58 A;  1XGM A;  4FLJ A;  3BIQ A;  4U70 A;  4EGE A;  1BOA A;  2EVO A;  2Q92 A;  3BIT A;  2GG5 A;  5CDV A;  4U73 A;  1WL6 A;  1C24 A;  3PKB A;  4U76 A;  4A6W A;  4IKS A;  1C23 A;  4U6W A;  3IG4 A;  2ADU A;  4U6E A;  1BN5 A;  2GGB A;  4FKC A;  1O0X A;  2V3X A;  3L24 A;  2BB7 A;  4FUK A;  4IPA A;  1B6A A;  1WN1 A;  1KP0 A;  2BN7 A;  2BWS A;  4MAT A;  2GG7 A;  3TAV A;  1KQ9 A;  1C21 A;  4IDY A;  1QZY A;  3RVA A;  4IEC A;  4U71 A;  2BWT A;  1N51 A;  1XGN A;  1YW7 A;  5JHU A;  5CDE A;  1XNZ A;  4IU6 A;  3BIP A;  1A16 A;  1QXW A;  4S2R P;  2GZ5 A;  1WY2 A;  3D27 A;  5JFR A;  1XGS A;  4PNC A;  4A6V A;  2GG2 A;  2G6P A;  3ROR A;  1C27 A;  2P99 A;  1MAT A;  4ZWO A;  2V6C A;  2BH3 A;  2GG3 A;  4U6C A;  4U6Z A;  2BWV A;  1JAW A;  2BHA A;  3IU7 A;  4OOK A;  2HOW A;  1M35 A; 
#chains in the Genus database with same CATH homology
 3MX6 A;  2B3K A;  2Q93 A;  2OAZ A;  1W2M A;  2P9A A;  3PKE A;  3IU8 A;  4IKR A;  4S2T P;  4JUQ A;  2GG0 A;  2Q95 A;  1CHM A;  1R5H A;  5CE6 A;  2OKN A;  3FMQ A;  4RZY A;  2Q96 A;  3L7G A;  1YW9 A;  4U1B A;  5JI6 A;  2ZSG A;  2P98 A;  5CDL A;  2BHB A;  2GTX A;  1XGO A;  4RZZ A;  2B3H A;  2GG8 A;  4S00 A;  5CNX A;  4FO7 A;  4IF7 A;  3IU9 A;  2GA2 A;  2EA2 A;  4FLK A;  3CB6 A;  1WKM A;  5D6F A;  2BHC A;  3PKD A;  3TB5 A;  2EA4 A;  2B3L A;  2V3Z A;  2BWW A;  1B59 A;  2GU6 A;  1W7V A;  2EVM A;  5CIK A;  3CB5 A;  2NQ6 A;  4KM3 A;  3FM3 A;  3MAT A;  4FLI A;  1WLR A;  2Q8K A;  1R5G A;  4S01 A;  4HXX A;  4Z7M A;  2DFI A;  1YW8 A;  4PV4 A;  2EVC A;  5FCH A;  4ZWP A;  2GU7 A;  4QR8 A;  2GU5 A;  4ZWU A;  2IW2 A;  1YJ3 A;  2Q94 A;  5FCF A;  2GG9 A;  2GGC A;  3Q6D A;  4FLL A;  1QXZ A;  4FO8 A;  5E5B A;  3CTZ A;  1WL9 A;  4U75 A;  2MAT A;  4B28 A;  2BWU A;  1WBQ A;  2V3Y A;  3MR1 A;  2GU4 A;  5D6E A;  1YVM A;  4R60 A;  4RGZ 1;  4ZNG A;  1KQ0 A;  2BWY A;  3FMR A;  3PKA A;  4IKU A;  4IKT A;  2NQ7 A;  5CLS A;  3S6B A;  2BHD A;  1Y1N A;  3PKC A;  4U69 A;  1C22 A;  1PV9 A;  1QXY A;  2BWX A;  4U6J A;  1R58 A;  1XGM A;  4FLJ A;  3BIQ A;  4U70 A;  4EGE A;  1BOA A;  2EVO A;  2Q92 A;  3BIT A;  2GG5 A;  5CDV A;  4U73 A;  1WL6 A;  1C24 A;  3PKB A;  4U76 A;  4A6W A;  4IKS A;  1C23 A;  4U6W A;  3IG4 A;  2ADU A;  4U6E A;  1BN5 A;  2GGB A;  4FKC A;  1O0X A;  2V3X A;  3L24 A;  2BB7 A;  4FUK A;  4IPA A;  1B6A A;  1WN1 A;  1KP0 A;  2BN7 A;  2BWS A;  4MAT A;  2GG7 A;  3TAV A;  1KQ9 A;  1C21 A;  4IDY A;  1QZY A;  3RVA A;  4IEC A;  4U71 A;  2BWT A;  1N51 A;  1XGN A;  1YW7 A;  5JHU A;  5CDE A;  1XNZ A;  4IU6 A;  3BIP A;  1A16 A;  1QXW A;  4S2R P;  2GZ5 A;  1WY2 A;  3D27 A;  5JFR A;  1XGS A;  4PNC A;  4A6V A;  2GG2 A;  2G6P A;  3ROR A;  1C27 A;  2P99 A;  1MAT A;  4ZWO A;  2V6C A;  2BH3 A;  2GG3 A;  4U6C A;  4U6Z A;  2BWV A;  1JAW A;  2BHA A;  3IU7 A;  4OOK A;  2HOW A;  1M35 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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