4U6EA

Hsmetap in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 101
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6eA00
5CLSA 2GG8A 3FM3A 4S2TP 4U73A 2DFIA 4U6ZA 2G6PA 3IU7A 4FLJA 3CB5A 1KP0A 5D6FA 2EA2A 2GG7A 2BWYA 5E5BA 4IECA 1XGSA 2GG0A 4U6JA 1PV9A 3MATA 2EVMA 2GTXA 3TAVA 4U1BA 4U71A 4A6WA 3FMQA 4R60A 2NQ6A 4IKTA 5CE6A 1C21A 2V3XA 3IU9A 2ADUA 2Q92A 2BWUA 4IKSA 2Q96A 2BWTA 2B3KA 3PKBA 4ZWOA 2BWXA 2EVOA 3D27A 2BWVA 1MATA 1QXWA 2GG2A 3MR1A 4MATA 1WLRA 4JUQA 1YW7A 2GG9A 1R5HA 2BHCA 2BB7A 1R5GA 5FCFA 1O0XA 2ZSGA 5CDLA 2Q8KA 2BWSA 2GGBA 2GZ5A 2HOWA 1N51A 2BH3A 4U6EA 4ZWUA 1XGOA 2IW2A 4EGEA 2V3YA 1WN1A 3L7GA 3RVAA 4IDYA 4RZYA 2B3HA 5CDEA 1WL9A 3IU8A 1XGMA 4S2RP 4ZWPA 1C23A 1B6AA 2P9AA 4FLLA 5JFRA 4RGZ1 2GU6A 2EVCA 2NQ7A 4IKRA 3BITA 4PNCA 4IKUA 2BHDA 2BN7A 1CHMA 2V6CA 1W7VA 2Q93A 1BOAA 4IPAA 3TB5A 1YVMA 1XGNA 3BIQA 4OOKA 2Q95A 4U70A 1WL6A 1C22A 1QXYA 2GU7A 4IF7A 4HXXA 3PKEA 2OAZA 2GA2A 4U6CA 4RZZA 2V3ZA 4B28A 2P99A 1XNZA 2GU5A 4U6WA 4U75A 1BN5A 4FUKA 1KQ0A 2GG3A 1YJ3A 1YW8A 2BHAA 4S00A 1A16A 1M35A 1Y1NA 2Q94A 5JHUA 5JI6A 4FO8A 4S01A 1B59A 2EA4A 4A6VA 5D6EA 5CIKA 4PV4A 1KQ9A 1QZYA 1WY2A 2GU4A 5CDVA 2GGCA 3MX6A 2MATA 3L24A 1W2MA 1WBQA 4ZNGA 1C24A 4IU6A 2B3LA 2OKNA 3CTZA 4FO7A 4U69A 3RORA 3PKAA 1C27A 1WKMA 3CB6A 5CNXA 3FMRA 4QR8A 1R58A 3BIPA 4FKCA 2BHBA 4FLIA 5FCHA 2P98A 2BWWA 3PKDA 2GG5A 3IG4A 4FLKA 4U76A 3S6BA 1YW9A 3Q6DA 1JAWA 4Z7MA 1QXZA 4KM3A 3PKCA
chains in the Genus database with same CATH superfamily
5CLSA 2GG8A 3FM3A 4S2TP 4U73A 2DFIA 4U6ZA 2G6PA 3IU7A 4FLJA 3CB5A 1KP0A 5D6FA 2EA2A 2GG7A 2BWYA 5E5BA 4IECA 1XGSA 2GG0A 4U6JA 1PV9A 3MATA 2EVMA 2GTXA 3TAVA 4U1BA 4U71A 4A6WA 3FMQA 4R60A 2NQ6A 4IKTA 5CE6A 1C21A 2V3XA 3IU9A 2ADUA 2Q92A 2BWUA 4IKSA 2Q96A 2BWTA 2B3KA 3PKBA 4ZWOA 2BWXA 2EVOA 3D27A 2BWVA 1MATA 1QXWA 2GG2A 3MR1A 4MATA 1WLRA 4JUQA 1YW7A 2GG9A 1R5HA 2BHCA 2BB7A 1R5GA 5FCFA 1O0XA 2ZSGA 5CDLA 2Q8KA 2BWSA 2GGBA 2GZ5A 2HOWA 1N51A 2BH3A 4U6EA 4ZWUA 1XGOA 2IW2A 4EGEA 2V3YA 1WN1A 3L7GA 3RVAA 4IDYA 4RZYA 2B3HA 5CDEA 1WL9A 3IU8A 1XGMA 4S2RP 4ZWPA 1C23A 1B6AA 2P9AA 4FLLA 5JFRA 4RGZ1 2GU6A 2EVCA 2NQ7A 4IKRA 3BITA 4PNCA 4IKUA 2BHDA 2BN7A 1CHMA 2V6CA 1W7VA 2Q93A 1BOAA 4IPAA 3TB5A 1YVMA 1XGNA 3BIQA 4OOKA 2Q95A 4U70A 1WL6A 1C22A 1QXYA 2GU7A 4IF7A 4HXXA 3PKEA 2OAZA 2GA2A 4U6CA 4RZZA 2V3ZA 4B28A 2P99A 1XNZA 2GU5A 4U6WA 4U75A 1BN5A 4FUKA 1KQ0A 2GG3A 1YJ3A 1YW8A 2BHAA 4S00A 1A16A 1M35A 1Y1NA 2Q94A 5JHUA 5JI6A 4FO8A 4S01A 1B59A 2EA4A 4A6VA 5D6EA 5CIKA 4PV4A 1KQ9A 1QZYA 1WY2A 2GU4A 5CDVA 2GGCA 3MX6A 2MATA 3L24A 1W2MA 1WBQA 4ZNGA 1C24A 4IU6A 2B3LA 2OKNA 3CTZA 4FO7A 4U69A 3RORA 3PKAA 1C27A 1WKMA 3CB6A 5CNXA 3FMRA 4QR8A 1R58A 3BIPA 4FKCA 2BHBA 4FLIA 5FCHA 2P98A 2BWWA 3PKDA 2GG5A 3IG4A 4FLKA 4U76A 3S6BA 1YW9A 3Q6DA 1JAWA 4Z7MA 1QXZA 4KM3A 3PKCA
chains in the Genus database with same CATH topology
5CLSA 2GG8A 3FM3A 4S2TP 4U73A 2DFIA 4U6ZA 2G6PA 3IU7A 4FLJA 3CB5A 1KP0A 5D6FA 2EA2A 2GG7A 2BWYA 5E5BA 4IECA 1XGSA 2GG0A 4U6JA 1PV9A 3MATA 2EVMA 2GTXA 3TAVA 4U1BA 4U71A 4A6WA 3FMQA 4R60A 2NQ6A 4IKTA 5CE6A 1C21A 2V3XA 3IU9A 2ADUA 2Q92A 2BWUA 4IKSA 2Q96A 2BWTA 2B3KA 3PKBA 4ZWOA 2BWXA 2EVOA 3D27A 2BWVA 1MATA 1QXWA 2GG2A 3MR1A 4MATA 1WLRA 4JUQA 1YW7A 2GG9A 1R5HA 2BHCA 2BB7A 1R5GA 5FCFA 1O0XA 2ZSGA 5CDLA 2Q8KA 2BWSA 2GGBA 2GZ5A 2HOWA 1N51A 2BH3A 4U6EA 4ZWUA 1XGOA 2IW2A 4EGEA 2V3YA 1WN1A 3L7GA 3RVAA 4IDYA 4RZYA 2B3HA 5CDEA 1WL9A 3IU8A 1XGMA 4S2RP 4ZWPA 1C23A 1B6AA 2P9AA 4FLLA 5JFRA 4RGZ1 2GU6A 2EVCA 2NQ7A 4IKRA 3BITA 4PNCA 4IKUA 2BHDA 2BN7A 1CHMA 2V6CA 1W7VA 2Q93A 1BOAA 4IPAA 3TB5A 1YVMA 1XGNA 3BIQA 4OOKA 2Q95A 4U70A 1WL6A 1C22A 1QXYA 2GU7A 4IF7A 4HXXA 3PKEA 2OAZA 2GA2A 4U6CA 4RZZA 2V3ZA 4B28A 2P99A 1XNZA 2GU5A 4U6WA 4U75A 1BN5A 4FUKA 1KQ0A 2GG3A 1YJ3A 1YW8A 2BHAA 4S00A 1A16A 1M35A 1Y1NA 2Q94A 5JHUA 5JI6A 4FO8A 4S01A 1B59A 2EA4A 4A6VA 5D6EA 5CIKA 4PV4A 1KQ9A 1QZYA 1WY2A 2GU4A 5CDVA 2GGCA 3MX6A 2MATA 3L24A 1W2MA 1WBQA 4ZNGA 1C24A 4IU6A 2B3LA 2OKNA 3CTZA 4FO7A 4U69A 3RORA 3PKAA 1C27A 1WKMA 3CB6A 5CNXA 3FMRA 4QR8A 1R58A 3BIPA 4FKCA 2BHBA 4FLIA 5FCHA 2P98A 2BWWA 3PKDA 2GG5A 3IG4A 4FLKA 4U76A 3S6BA 1YW9A 3Q6DA 1JAWA 4Z7MA 1QXZA 4KM3A 3PKCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CLS A;  2GG8 A;  3FM3 A;  4S2T P;  4U73 A;  2DFI A;  4U6Z A;  2G6P A;  3IU7 A;  4FLJ A;  3CB5 A;  1KP0 A;  5D6F A;  2EA2 A;  2GG7 A;  2BWY A;  5E5B A;  4IEC A;  1XGS A;  2GG0 A;  4U6J A;  1PV9 A;  3MAT A;  2EVM A;  2GTX A;  3TAV A;  4U1B A;  4U71 A;  4A6W A;  3FMQ A;  4R60 A;  2NQ6 A;  4IKT A;  5CE6 A;  1C21 A;  2V3X A;  3IU9 A;  2ADU A;  2Q92 A;  2BWU A;  4IKS A;  2Q96 A;  2BWT A;  2B3K A;  3PKB A;  4ZWO A;  2BWX A;  2EVO A;  3D27 A;  2BWV A;  1MAT A;  1QXW A;  2GG2 A;  3MR1 A;  4MAT A;  1WLR A;  4JUQ A;  1YW7 A;  2GG9 A;  1R5H A;  2BHC A;  2BB7 A;  1R5G A;  5FCF A;  1O0X A;  2ZSG A;  5CDL A;  2Q8K A;  2BWS A;  2GGB A;  2GZ5 A;  2HOW A;  1N51 A;  2BH3 A;  4U6E A;  4ZWU A;  1XGO A;  2IW2 A;  4EGE A;  2V3Y A;  1WN1 A;  3L7G A;  3RVA A;  4IDY A;  4RZY A;  2B3H A;  5CDE A;  1WL9 A;  3IU8 A;  1XGM A;  4S2R P;  4ZWP A;  1C23 A;  1B6A A;  2P9A A;  4FLL A;  5JFR A;  4RGZ 1;  2GU6 A;  2EVC A;  2NQ7 A;  4IKR A;  3BIT A;  4PNC A;  4IKU A;  2BHD A;  2BN7 A;  1CHM A;  2V6C A;  1W7V A;  2Q93 A;  1BOA A;  4IPA A;  3TB5 A;  1YVM A;  1XGN A;  3BIQ A;  4OOK A;  2Q95 A;  4U70 A;  1WL6 A;  1C22 A;  1QXY A;  2GU7 A;  4IF7 A;  4HXX A;  3PKE A;  2OAZ A;  2GA2 A;  4U6C A;  4RZZ A;  2V3Z A;  4B28 A;  2P99 A;  1XNZ A;  2GU5 A;  4U6W A;  4U75 A;  1BN5 A;  4FUK A;  1KQ0 A;  2GG3 A;  1YJ3 A;  1YW8 A;  2BHA A;  4S00 A;  1A16 A;  1M35 A;  1Y1N A;  2Q94 A;  5JHU A;  5JI6 A;  4FO8 A;  4S01 A;  1B59 A;  2EA4 A;  4A6V A;  5D6E A;  5CIK A;  4PV4 A;  1KQ9 A;  1QZY A;  1WY2 A;  2GU4 A;  5CDV A;  2GGC A;  3MX6 A;  2MAT A;  3L24 A;  1W2M A;  1WBQ A;  4ZNG A;  1C24 A;  4IU6 A;  2B3L A;  2OKN A;  3CTZ A;  4FO7 A;  4U69 A;  3ROR A;  3PKA A;  1C27 A;  1WKM A;  3CB6 A;  5CNX A;  3FMR A;  4QR8 A;  1R58 A;  3BIP A;  4FKC A;  2BHB A;  4FLI A;  5FCH A;  2P98 A;  2BWW A;  3PKD A;  2GG5 A;  3IG4 A;  4FLK A;  4U76 A;  3S6B A;  1YW9 A;  3Q6D A;  1JAW A;  4Z7M A;  1QXZ A;  4KM3 A;  3PKC A; 
#chains in the Genus database with same CATH topology
 5CLS A;  2GG8 A;  3FM3 A;  4S2T P;  4U73 A;  2DFI A;  4U6Z A;  2G6P A;  3IU7 A;  4FLJ A;  3CB5 A;  1KP0 A;  5D6F A;  2EA2 A;  2GG7 A;  2BWY A;  5E5B A;  4IEC A;  1XGS A;  2GG0 A;  4U6J A;  1PV9 A;  3MAT A;  2EVM A;  2GTX A;  3TAV A;  4U1B A;  4U71 A;  4A6W A;  3FMQ A;  4R60 A;  2NQ6 A;  4IKT A;  5CE6 A;  1C21 A;  2V3X A;  3IU9 A;  2ADU A;  2Q92 A;  2BWU A;  4IKS A;  2Q96 A;  2BWT A;  2B3K A;  3PKB A;  4ZWO A;  2BWX A;  2EVO A;  3D27 A;  2BWV A;  1MAT A;  1QXW A;  2GG2 A;  3MR1 A;  4MAT A;  1WLR A;  4JUQ A;  1YW7 A;  2GG9 A;  1R5H A;  2BHC A;  2BB7 A;  1R5G A;  5FCF A;  1O0X A;  2ZSG A;  5CDL A;  2Q8K A;  2BWS A;  2GGB A;  2GZ5 A;  2HOW A;  1N51 A;  2BH3 A;  4U6E A;  4ZWU A;  1XGO A;  2IW2 A;  4EGE A;  2V3Y A;  1WN1 A;  3L7G A;  3RVA A;  4IDY A;  4RZY A;  2B3H A;  5CDE A;  1WL9 A;  3IU8 A;  1XGM A;  4S2R P;  4ZWP A;  1C23 A;  1B6A A;  2P9A A;  4FLL A;  5JFR A;  4RGZ 1;  2GU6 A;  2EVC A;  2NQ7 A;  4IKR A;  3BIT A;  4PNC A;  4IKU A;  2BHD A;  2BN7 A;  1CHM A;  2V6C A;  1W7V A;  2Q93 A;  1BOA A;  4IPA A;  3TB5 A;  1YVM A;  1XGN A;  3BIQ A;  4OOK A;  2Q95 A;  4U70 A;  1WL6 A;  1C22 A;  1QXY A;  2GU7 A;  4IF7 A;  4HXX A;  3PKE A;  2OAZ A;  2GA2 A;  4U6C A;  4RZZ A;  2V3Z A;  4B28 A;  2P99 A;  1XNZ A;  2GU5 A;  4U6W A;  4U75 A;  1BN5 A;  4FUK A;  1KQ0 A;  2GG3 A;  1YJ3 A;  1YW8 A;  2BHA A;  4S00 A;  1A16 A;  1M35 A;  1Y1N A;  2Q94 A;  5JHU A;  5JI6 A;  4FO8 A;  4S01 A;  1B59 A;  2EA4 A;  4A6V A;  5D6E A;  5CIK A;  4PV4 A;  1KQ9 A;  1QZY A;  1WY2 A;  2GU4 A;  5CDV A;  2GGC A;  3MX6 A;  2MAT A;  3L24 A;  1W2M A;  1WBQ A;  4ZNG A;  1C24 A;  4IU6 A;  2B3L A;  2OKN A;  3CTZ A;  4FO7 A;  4U69 A;  3ROR A;  3PKA A;  1C27 A;  1WKM A;  3CB6 A;  5CNX A;  3FMR A;  4QR8 A;  1R58 A;  3BIP A;  4FKC A;  2BHB A;  4FLI A;  5FCH A;  2P98 A;  2BWW A;  3PKD A;  2GG5 A;  3IG4 A;  4FLK A;  4U76 A;  3S6B A;  1YW9 A;  3Q6D A;  1JAW A;  4Z7M A;  1QXZ A;  4KM3 A;  3PKC A; 
#chains in the Genus database with same CATH homology
 5CLS A;  2GG8 A;  3FM3 A;  4S2T P;  4U73 A;  2DFI A;  4U6Z A;  2G6P A;  3IU7 A;  4FLJ A;  3CB5 A;  1KP0 A;  5D6F A;  2EA2 A;  2GG7 A;  2BWY A;  5E5B A;  4IEC A;  1XGS A;  2GG0 A;  4U6J A;  1PV9 A;  3MAT A;  2EVM A;  2GTX A;  3TAV A;  4U1B A;  4U71 A;  4A6W A;  3FMQ A;  4R60 A;  2NQ6 A;  4IKT A;  5CE6 A;  1C21 A;  2V3X A;  3IU9 A;  2ADU A;  2Q92 A;  2BWU A;  4IKS A;  2Q96 A;  2BWT A;  2B3K A;  3PKB A;  4ZWO A;  2BWX A;  2EVO A;  3D27 A;  2BWV A;  1MAT A;  1QXW A;  2GG2 A;  3MR1 A;  4MAT A;  1WLR A;  4JUQ A;  1YW7 A;  2GG9 A;  1R5H A;  2BHC A;  2BB7 A;  1R5G A;  5FCF A;  1O0X A;  2ZSG A;  5CDL A;  2Q8K A;  2BWS A;  2GGB A;  2GZ5 A;  2HOW A;  1N51 A;  2BH3 A;  4U6E A;  4ZWU A;  1XGO A;  2IW2 A;  4EGE A;  2V3Y A;  1WN1 A;  3L7G A;  3RVA A;  4IDY A;  4RZY A;  2B3H A;  5CDE A;  1WL9 A;  3IU8 A;  1XGM A;  4S2R P;  4ZWP A;  1C23 A;  1B6A A;  2P9A A;  4FLL A;  5JFR A;  4RGZ 1;  2GU6 A;  2EVC A;  2NQ7 A;  4IKR A;  3BIT A;  4PNC A;  4IKU A;  2BHD A;  2BN7 A;  1CHM A;  2V6C A;  1W7V A;  2Q93 A;  1BOA A;  4IPA A;  3TB5 A;  1YVM A;  1XGN A;  3BIQ A;  4OOK A;  2Q95 A;  4U70 A;  1WL6 A;  1C22 A;  1QXY A;  2GU7 A;  4IF7 A;  4HXX A;  3PKE A;  2OAZ A;  2GA2 A;  4U6C A;  4RZZ A;  2V3Z A;  4B28 A;  2P99 A;  1XNZ A;  2GU5 A;  4U6W A;  4U75 A;  1BN5 A;  4FUK A;  1KQ0 A;  2GG3 A;  1YJ3 A;  1YW8 A;  2BHA A;  4S00 A;  1A16 A;  1M35 A;  1Y1N A;  2Q94 A;  5JHU A;  5JI6 A;  4FO8 A;  4S01 A;  1B59 A;  2EA4 A;  4A6V A;  5D6E A;  5CIK A;  4PV4 A;  1KQ9 A;  1QZY A;  1WY2 A;  2GU4 A;  5CDV A;  2GGC A;  3MX6 A;  2MAT A;  3L24 A;  1W2M A;  1WBQ A;  4ZNG A;  1C24 A;  4IU6 A;  2B3L A;  2OKN A;  3CTZ A;  4FO7 A;  4U69 A;  3ROR A;  3PKA A;  1C27 A;  1WKM A;  3CB6 A;  5CNX A;  3FMR A;  4QR8 A;  1R58 A;  3BIP A;  4FKC A;  2BHB A;  4FLI A;  5FCH A;  2P98 A;  2BWW A;  3PKD A;  2GG5 A;  3IG4 A;  4FLK A;  4U76 A;  3S6B A;  1YW9 A;  3Q6D A;  1JAW A;  4Z7M A;  1QXZ A;  4KM3 A;  3PKC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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