4U75A

Hsmetap (f309m) in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u75A00
1R58A 5D6EA 2BHCA 3TAVA 4IECA 5CDVA 1R5HA 3RVAA 4U71A 4IF7A 2BHDA 4ZWOA 1BOAA 1QZYA 4FLLA 2HOWA 2Q92A 2EA4A 4IPAA 2P9AA 2BWYA 4FLIA 4S00A 4RZYA 5CE6A 2BWTA 2BH3A 1XGNA 2OAZA 4MATA 4B28A 3MX6A 1C23A 4S01A 2GU7A 2IW2A 2GG9A 5JFRA 1MATA 4IU6A 5CLSA 2GG7A 1B59A 3IU7A 3PKAA 4FUKA 4U73A 2V6CA 1JAWA 1CHMA 4U6ZA 4U6JA 2BWVA 2EVOA 5CNXA 3MATA 1YW9A 1O0XA 3L7GA 4ZWUA 4IKRA 2BHBA 3CTZA 3MR1A 3L24A 3PKBA 1C24A 4IDYA 4JUQA 2Q95A 4QR8A 2Q96A 4A6WA 3CB6A 1W2MA 3D27A 3PKEA 3Q6DA 4U1BA 3S6BA 1XGOA 2NQ6A 1WL9A 2BWUA 2GG5A 2EA2A 5FCHA 2B3LA 4U70A 1QXYA 4FO7A 5CDLA 2V3ZA 4IKTA 5FCFA 4U6EA 2NQ7A 2ZSGA 4S2TP 2GGCA 5CIKA 1BN5A 1C27A 2Q8KA 2OKNA 4EGEA 4IKSA 3CB5A 4RZZA 4U75A 4FLJA 2Q94A 2GU5A 2GGBA 1A16A 2EVMA 1M35A 1R5GA 2B3KA 1QXWA 2P98A 3RORA 1YVMA 2BWXA 1WLRA 2EVCA 2GU6A 1YJ3A 2BN7A 4HXXA 4RGZ1 2V3XA 3PKDA 4PNCA 3TB5A 5JI6A 2GZ5A 1C22A 2GU4A 4U6CA 5CDEA 5JHUA 2V3YA 4IKUA 2DFIA 1QXZA 4FO8A 4PV4A 1B6AA 4KM3A 1XNZA 3BIQA 2B3HA 1KQ0A 1WBQA 1YW8A 2GA2A 2P99A 1KQ9A 3FMQA 1N51A 3IU8A 4FKCA 3FMRA 2BHAA 4Z7MA 2G6PA 1WY2A 4U69A 3IU9A 1PV9A 4R60A 2BB7A 2GTXA 1WL6A 3BITA 1Y1NA 2GG8A 4OOKA 4A6VA 5D6FA 4S2RP 4ZNGA 1WKMA 5E5BA 4FLKA 3PKCA 2GG0A 2GG2A 2BWSA 3FM3A 1YW7A 4U6WA 2MATA 4U76A 1W7VA 3IG4A 3BIPA 2Q93A 1C21A 4ZWPA 1KP0A 2GG3A 2BWWA 1XGSA 1WN1A 1XGMA 2ADUA
chains in the Genus database with same CATH superfamily
1R58A 5D6EA 2BHCA 3TAVA 4IECA 5CDVA 1R5HA 3RVAA 4U71A 4IF7A 2BHDA 4ZWOA 1BOAA 1QZYA 4FLLA 2HOWA 2Q92A 2EA4A 4IPAA 2P9AA 2BWYA 4FLIA 4S00A 4RZYA 5CE6A 2BWTA 2BH3A 1XGNA 2OAZA 4MATA 4B28A 3MX6A 1C23A 4S01A 2GU7A 2IW2A 2GG9A 5JFRA 1MATA 4IU6A 5CLSA 2GG7A 1B59A 3IU7A 3PKAA 4FUKA 4U73A 2V6CA 1JAWA 1CHMA 4U6ZA 4U6JA 2BWVA 2EVOA 5CNXA 3MATA 1YW9A 1O0XA 3L7GA 4ZWUA 4IKRA 2BHBA 3CTZA 3MR1A 3L24A 3PKBA 1C24A 4IDYA 4JUQA 2Q95A 4QR8A 2Q96A 4A6WA 3CB6A 1W2MA 3D27A 3PKEA 3Q6DA 4U1BA 3S6BA 1XGOA 2NQ6A 1WL9A 2BWUA 2GG5A 2EA2A 5FCHA 2B3LA 4U70A 1QXYA 4FO7A 5CDLA 2V3ZA 4IKTA 5FCFA 4U6EA 2NQ7A 2ZSGA 4S2TP 2GGCA 5CIKA 1BN5A 1C27A 2Q8KA 2OKNA 4EGEA 4IKSA 3CB5A 4RZZA 4U75A 4FLJA 2Q94A 2GU5A 2GGBA 1A16A 2EVMA 1M35A 1R5GA 2B3KA 1QXWA 2P98A 3RORA 1YVMA 2BWXA 1WLRA 2EVCA 2GU6A 1YJ3A 2BN7A 4HXXA 4RGZ1 2V3XA 3PKDA 4PNCA 3TB5A 5JI6A 2GZ5A 1C22A 2GU4A 4U6CA 5CDEA 5JHUA 2V3YA 4IKUA 2DFIA 1QXZA 4FO8A 4PV4A 1B6AA 4KM3A 1XNZA 3BIQA 2B3HA 1KQ0A 1WBQA 1YW8A 2GA2A 2P99A 1KQ9A 3FMQA 1N51A 3IU8A 4FKCA 3FMRA 2BHAA 4Z7MA 2G6PA 1WY2A 4U69A 3IU9A 1PV9A 4R60A 2BB7A 2GTXA 1WL6A 3BITA 1Y1NA 2GG8A 4OOKA 4A6VA 5D6FA 4S2RP 4ZNGA 1WKMA 5E5BA 4FLKA 3PKCA 2GG0A 2GG2A 2BWSA 3FM3A 1YW7A 4U6WA 2MATA 4U76A 1W7VA 3IG4A 3BIPA 2Q93A 1C21A 4ZWPA 1KP0A 2GG3A 2BWWA 1XGSA 1WN1A 1XGMA 2ADUA
chains in the Genus database with same CATH topology
1R58A 5D6EA 2BHCA 3TAVA 4IECA 5CDVA 1R5HA 3RVAA 4U71A 4IF7A 2BHDA 4ZWOA 1BOAA 1QZYA 4FLLA 2HOWA 2Q92A 2EA4A 4IPAA 2P9AA 2BWYA 4FLIA 4S00A 4RZYA 5CE6A 2BWTA 2BH3A 1XGNA 2OAZA 4MATA 4B28A 3MX6A 1C23A 4S01A 2GU7A 2IW2A 2GG9A 5JFRA 1MATA 4IU6A 5CLSA 2GG7A 1B59A 3IU7A 3PKAA 4FUKA 4U73A 2V6CA 1JAWA 1CHMA 4U6ZA 4U6JA 2BWVA 2EVOA 5CNXA 3MATA 1YW9A 1O0XA 3L7GA 4ZWUA 4IKRA 2BHBA 3CTZA 3MR1A 3L24A 3PKBA 1C24A 4IDYA 4JUQA 2Q95A 4QR8A 2Q96A 4A6WA 3CB6A 1W2MA 3D27A 3PKEA 3Q6DA 4U1BA 3S6BA 1XGOA 2NQ6A 1WL9A 2BWUA 2GG5A 2EA2A 5FCHA 2B3LA 4U70A 1QXYA 4FO7A 5CDLA 2V3ZA 4IKTA 5FCFA 4U6EA 2NQ7A 2ZSGA 4S2TP 2GGCA 5CIKA 1BN5A 1C27A 2Q8KA 2OKNA 4EGEA 4IKSA 3CB5A 4RZZA 4U75A 4FLJA 2Q94A 2GU5A 2GGBA 1A16A 2EVMA 1M35A 1R5GA 2B3KA 1QXWA 2P98A 3RORA 1YVMA 2BWXA 1WLRA 2EVCA 2GU6A 1YJ3A 2BN7A 4HXXA 4RGZ1 2V3XA 3PKDA 4PNCA 3TB5A 5JI6A 2GZ5A 1C22A 2GU4A 4U6CA 5CDEA 5JHUA 2V3YA 4IKUA 2DFIA 1QXZA 4FO8A 4PV4A 1B6AA 4KM3A 1XNZA 3BIQA 2B3HA 1KQ0A 1WBQA 1YW8A 2GA2A 2P99A 1KQ9A 3FMQA 1N51A 3IU8A 4FKCA 3FMRA 2BHAA 4Z7MA 2G6PA 1WY2A 4U69A 3IU9A 1PV9A 4R60A 2BB7A 2GTXA 1WL6A 3BITA 1Y1NA 2GG8A 4OOKA 4A6VA 5D6FA 4S2RP 4ZNGA 1WKMA 5E5BA 4FLKA 3PKCA 2GG0A 2GG2A 2BWSA 3FM3A 1YW7A 4U6WA 2MATA 4U76A 1W7VA 3IG4A 3BIPA 2Q93A 1C21A 4ZWPA 1KP0A 2GG3A 2BWWA 1XGSA 1WN1A 1XGMA 2ADUA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1R58 A;  5D6E A;  2BHC A;  3TAV A;  4IEC A;  5CDV A;  1R5H A;  3RVA A;  4U71 A;  4IF7 A;  2BHD A;  4ZWO A;  1BOA A;  1QZY A;  4FLL A;  2HOW A;  2Q92 A;  2EA4 A;  4IPA A;  2P9A A;  2BWY A;  4FLI A;  4S00 A;  4RZY A;  5CE6 A;  2BWT A;  2BH3 A;  1XGN A;  2OAZ A;  4MAT A;  4B28 A;  3MX6 A;  1C23 A;  4S01 A;  2GU7 A;  2IW2 A;  2GG9 A;  5JFR A;  1MAT A;  4IU6 A;  5CLS A;  2GG7 A;  1B59 A;  3IU7 A;  3PKA A;  4FUK A;  4U73 A;  2V6C A;  1JAW A;  1CHM A;  4U6Z A;  4U6J A;  2BWV A;  2EVO A;  5CNX A;  3MAT A;  1YW9 A;  1O0X A;  3L7G A;  4ZWU A;  4IKR A;  2BHB A;  3CTZ A;  3MR1 A;  3L24 A;  3PKB A;  1C24 A;  4IDY A;  4JUQ A;  2Q95 A;  4QR8 A;  2Q96 A;  4A6W A;  3CB6 A;  1W2M A;  3D27 A;  3PKE A;  3Q6D A;  4U1B A;  3S6B A;  1XGO A;  2NQ6 A;  1WL9 A;  2BWU A;  2GG5 A;  2EA2 A;  5FCH A;  2B3L A;  4U70 A;  1QXY A;  4FO7 A;  5CDL A;  2V3Z A;  4IKT A;  5FCF A;  4U6E A;  2NQ7 A;  2ZSG A;  4S2T P;  2GGC A;  5CIK A;  1BN5 A;  1C27 A;  2Q8K A;  2OKN A;  4EGE A;  4IKS A;  3CB5 A;  4RZZ A;  4U75 A;  4FLJ A;  2Q94 A;  2GU5 A;  2GGB A;  1A16 A;  2EVM A;  1M35 A;  1R5G A;  2B3K A;  1QXW A;  2P98 A;  3ROR A;  1YVM A;  2BWX A;  1WLR A;  2EVC A;  2GU6 A;  1YJ3 A;  2BN7 A;  4HXX A;  4RGZ 1;  2V3X A;  3PKD A;  4PNC A;  3TB5 A;  5JI6 A;  2GZ5 A;  1C22 A;  2GU4 A;  4U6C A;  5CDE A;  5JHU A;  2V3Y A;  4IKU A;  2DFI A;  1QXZ A;  4FO8 A;  4PV4 A;  1B6A A;  4KM3 A;  1XNZ A;  3BIQ A;  2B3H A;  1KQ0 A;  1WBQ A;  1YW8 A;  2GA2 A;  2P99 A;  1KQ9 A;  3FMQ A;  1N51 A;  3IU8 A;  4FKC A;  3FMR A;  2BHA A;  4Z7M A;  2G6P A;  1WY2 A;  4U69 A;  3IU9 A;  1PV9 A;  4R60 A;  2BB7 A;  2GTX A;  1WL6 A;  3BIT A;  1Y1N A;  2GG8 A;  4OOK A;  4A6V A;  5D6F A;  4S2R P;  4ZNG A;  1WKM A;  5E5B A;  4FLK A;  3PKC A;  2GG0 A;  2GG2 A;  2BWS A;  3FM3 A;  1YW7 A;  4U6W A;  2MAT A;  4U76 A;  1W7V A;  3IG4 A;  3BIP A;  2Q93 A;  1C21 A;  4ZWP A;  1KP0 A;  2GG3 A;  2BWW A;  1XGS A;  1WN1 A;  1XGM A;  2ADU A; 
#chains in the Genus database with same CATH topology
 1R58 A;  5D6E A;  2BHC A;  3TAV A;  4IEC A;  5CDV A;  1R5H A;  3RVA A;  4U71 A;  4IF7 A;  2BHD A;  4ZWO A;  1BOA A;  1QZY A;  4FLL A;  2HOW A;  2Q92 A;  2EA4 A;  4IPA A;  2P9A A;  2BWY A;  4FLI A;  4S00 A;  4RZY A;  5CE6 A;  2BWT A;  2BH3 A;  1XGN A;  2OAZ A;  4MAT A;  4B28 A;  3MX6 A;  1C23 A;  4S01 A;  2GU7 A;  2IW2 A;  2GG9 A;  5JFR A;  1MAT A;  4IU6 A;  5CLS A;  2GG7 A;  1B59 A;  3IU7 A;  3PKA A;  4FUK A;  4U73 A;  2V6C A;  1JAW A;  1CHM A;  4U6Z A;  4U6J A;  2BWV A;  2EVO A;  5CNX A;  3MAT A;  1YW9 A;  1O0X A;  3L7G A;  4ZWU A;  4IKR A;  2BHB A;  3CTZ A;  3MR1 A;  3L24 A;  3PKB A;  1C24 A;  4IDY A;  4JUQ A;  2Q95 A;  4QR8 A;  2Q96 A;  4A6W A;  3CB6 A;  1W2M A;  3D27 A;  3PKE A;  3Q6D A;  4U1B A;  3S6B A;  1XGO A;  2NQ6 A;  1WL9 A;  2BWU A;  2GG5 A;  2EA2 A;  5FCH A;  2B3L A;  4U70 A;  1QXY A;  4FO7 A;  5CDL A;  2V3Z A;  4IKT A;  5FCF A;  4U6E A;  2NQ7 A;  2ZSG A;  4S2T P;  2GGC A;  5CIK A;  1BN5 A;  1C27 A;  2Q8K A;  2OKN A;  4EGE A;  4IKS A;  3CB5 A;  4RZZ A;  4U75 A;  4FLJ A;  2Q94 A;  2GU5 A;  2GGB A;  1A16 A;  2EVM A;  1M35 A;  1R5G A;  2B3K A;  1QXW A;  2P98 A;  3ROR A;  1YVM A;  2BWX A;  1WLR A;  2EVC A;  2GU6 A;  1YJ3 A;  2BN7 A;  4HXX A;  4RGZ 1;  2V3X A;  3PKD A;  4PNC A;  3TB5 A;  5JI6 A;  2GZ5 A;  1C22 A;  2GU4 A;  4U6C A;  5CDE A;  5JHU A;  2V3Y A;  4IKU A;  2DFI A;  1QXZ A;  4FO8 A;  4PV4 A;  1B6A A;  4KM3 A;  1XNZ A;  3BIQ A;  2B3H A;  1KQ0 A;  1WBQ A;  1YW8 A;  2GA2 A;  2P99 A;  1KQ9 A;  3FMQ A;  1N51 A;  3IU8 A;  4FKC A;  3FMR A;  2BHA A;  4Z7M A;  2G6P A;  1WY2 A;  4U69 A;  3IU9 A;  1PV9 A;  4R60 A;  2BB7 A;  2GTX A;  1WL6 A;  3BIT A;  1Y1N A;  2GG8 A;  4OOK A;  4A6V A;  5D6F A;  4S2R P;  4ZNG A;  1WKM A;  5E5B A;  4FLK A;  3PKC A;  2GG0 A;  2GG2 A;  2BWS A;  3FM3 A;  1YW7 A;  4U6W A;  2MAT A;  4U76 A;  1W7V A;  3IG4 A;  3BIP A;  2Q93 A;  1C21 A;  4ZWP A;  1KP0 A;  2GG3 A;  2BWW A;  1XGS A;  1WN1 A;  1XGM A;  2ADU A; 
#chains in the Genus database with same CATH homology
 1R58 A;  5D6E A;  2BHC A;  3TAV A;  4IEC A;  5CDV A;  1R5H A;  3RVA A;  4U71 A;  4IF7 A;  2BHD A;  4ZWO A;  1BOA A;  1QZY A;  4FLL A;  2HOW A;  2Q92 A;  2EA4 A;  4IPA A;  2P9A A;  2BWY A;  4FLI A;  4S00 A;  4RZY A;  5CE6 A;  2BWT A;  2BH3 A;  1XGN A;  2OAZ A;  4MAT A;  4B28 A;  3MX6 A;  1C23 A;  4S01 A;  2GU7 A;  2IW2 A;  2GG9 A;  5JFR A;  1MAT A;  4IU6 A;  5CLS A;  2GG7 A;  1B59 A;  3IU7 A;  3PKA A;  4FUK A;  4U73 A;  2V6C A;  1JAW A;  1CHM A;  4U6Z A;  4U6J A;  2BWV A;  2EVO A;  5CNX A;  3MAT A;  1YW9 A;  1O0X A;  3L7G A;  4ZWU A;  4IKR A;  2BHB A;  3CTZ A;  3MR1 A;  3L24 A;  3PKB A;  1C24 A;  4IDY A;  4JUQ A;  2Q95 A;  4QR8 A;  2Q96 A;  4A6W A;  3CB6 A;  1W2M A;  3D27 A;  3PKE A;  3Q6D A;  4U1B A;  3S6B A;  1XGO A;  2NQ6 A;  1WL9 A;  2BWU A;  2GG5 A;  2EA2 A;  5FCH A;  2B3L A;  4U70 A;  1QXY A;  4FO7 A;  5CDL A;  2V3Z A;  4IKT A;  5FCF A;  4U6E A;  2NQ7 A;  2ZSG A;  4S2T P;  2GGC A;  5CIK A;  1BN5 A;  1C27 A;  2Q8K A;  2OKN A;  4EGE A;  4IKS A;  3CB5 A;  4RZZ A;  4U75 A;  4FLJ A;  2Q94 A;  2GU5 A;  2GGB A;  1A16 A;  2EVM A;  1M35 A;  1R5G A;  2B3K A;  1QXW A;  2P98 A;  3ROR A;  1YVM A;  2BWX A;  1WLR A;  2EVC A;  2GU6 A;  1YJ3 A;  2BN7 A;  4HXX A;  4RGZ 1;  2V3X A;  3PKD A;  4PNC A;  3TB5 A;  5JI6 A;  2GZ5 A;  1C22 A;  2GU4 A;  4U6C A;  5CDE A;  5JHU A;  2V3Y A;  4IKU A;  2DFI A;  1QXZ A;  4FO8 A;  4PV4 A;  1B6A A;  4KM3 A;  1XNZ A;  3BIQ A;  2B3H A;  1KQ0 A;  1WBQ A;  1YW8 A;  2GA2 A;  2P99 A;  1KQ9 A;  3FMQ A;  1N51 A;  3IU8 A;  4FKC A;  3FMR A;  2BHA A;  4Z7M A;  2G6P A;  1WY2 A;  4U69 A;  3IU9 A;  1PV9 A;  4R60 A;  2BB7 A;  2GTX A;  1WL6 A;  3BIT A;  1Y1N A;  2GG8 A;  4OOK A;  4A6V A;  5D6F A;  4S2R P;  4ZNG A;  1WKM A;  5E5B A;  4FLK A;  3PKC A;  2GG0 A;  2GG2 A;  2BWS A;  3FM3 A;  1YW7 A;  4U6W A;  2MAT A;  4U76 A;  1W7V A;  3IG4 A;  3BIP A;  2Q93 A;  1C21 A;  4ZWP A;  1KP0 A;  2GG3 A;  2BWW A;  1XGS A;  1WN1 A;  1XGM A;  2ADU A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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