4U75A

Hsmetap (f309m) in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase 1
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
source organism Homo sapiens
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u75A00
1XGOA 4JUQA 3IU7A 1MATA 3BITA 1M35A 2GG9A 4IDYA 2B3KA 4QR8A 1KP0A 1WY2A 4PV4A 1WKMA 2V3YA 4IKTA 4ZWPA 2V3ZA 2Q8KA 2BWYA 1C23A 1CHMA 1BOAA 1XGMA 1YVMA 1QXZA 1WL6A 4B28A 2GU5A 1R58A 2BH3A 3FMRA 4ZWUA 2HOWA 2GG0A 1W2MA 1YW7A 2Q92A 1YW9A 5FCHA 2P9AA 1B59A 3CTZA 2GG7A 5CIKA 4A6WA 2V6CA 1XGSA 5CDLA 3MATA 3D27A 2Q96A 4FO7A 1C22A 3PKBA 2NQ6A 2EA2A 2GG5A 4IKSA 2G6PA 4FLIA 2ADUA 4A6VA 2BHCA 5JI6A 3BIQA 2GU7A 2BHDA 4ZNGA 2B3HA 2BWWA 1QXYA 1KQ0A 4KM3A 2GU4A 5E5BA 1YW8A 4U6JA 5CDVA 2DFIA 3PKAA 4Z7MA 3RORA 2EVOA 3BIPA 5FCFA 2OAZA 2BWSA 2EVCA 3IU8A 5CNXA 2EVMA 4FLKA 3L24A 1BN5A 2IW2A 3PKEA 4S00A 4IPAA 4R60A 4U6EA 2P99A 4U73A 4U6CA 4FKCA 3IU9A 4IU6A 1WBQA 3TB5A 2Q95A 2GGCA 4U75A 3RVAA 2P98A 3PKCA 3TAVA 1JAWA 2NQ7A 4RZZA 4ZWOA 2B3LA 4OOKA 4S2TP 1C21A 1A16A 4FUKA 1WN1A 3IG4A 4S2RP 2GU6A 1Y1NA 1C24A 1WL9A 2GG2A 2V3XA 4HXXA 1QXWA 2GZ5A 4U6ZA 5CE6A 4RGZ1 4RZYA 4IKUA 4FO8A 4U1BA 2BN7A 5CDEA 4IECA 4U6WA 1YJ3A 4PNCA 2EA4A 2BHAA 4S01A 3CB6A 1R5GA 2BWUA 1PV9A 1XGNA 4U69A 2GG3A 2BWXA 2MATA 2Q93A 2BHBA 4IKRA 1O0XA 3FM3A 4FLJA 4IF7A 1C27A 2BB7A 2GTXA 1R5HA 5JHUA 2GA2A 1WLRA 2OKNA 3MR1A 1KQ9A 4U76A 4U71A 5D6FA 3FMQA 2Q94A 5CLSA 4FLLA 5JFRA 3Q6DA 1W7VA 2GGBA 3L7GA 1B6AA 3MX6A 1N51A 2BWTA 5D6EA 4EGEA 2GG8A 1XNZA 3PKDA 3S6BA 3CB5A 4U70A 2BWVA 2ZSGA 1QZYA 4MATA
chains in the Genus database with same CATH superfamily
1XGOA 4JUQA 3IU7A 1MATA 3BITA 1M35A 2GG9A 4IDYA 2B3KA 4QR8A 1KP0A 1WY2A 4PV4A 1WKMA 2V3YA 4IKTA 4ZWPA 2V3ZA 2Q8KA 2BWYA 1C23A 1CHMA 1BOAA 1XGMA 1YVMA 1QXZA 1WL6A 4B28A 2GU5A 1R58A 2BH3A 3FMRA 4ZWUA 2HOWA 2GG0A 1W2MA 1YW7A 2Q92A 1YW9A 5FCHA 2P9AA 1B59A 3CTZA 2GG7A 5CIKA 4A6WA 2V6CA 1XGSA 5CDLA 3MATA 3D27A 2Q96A 4FO7A 1C22A 3PKBA 2NQ6A 2EA2A 2GG5A 4IKSA 2G6PA 4FLIA 2ADUA 4A6VA 2BHCA 5JI6A 3BIQA 2GU7A 2BHDA 4ZNGA 2B3HA 2BWWA 1QXYA 1KQ0A 4KM3A 2GU4A 5E5BA 1YW8A 4U6JA 5CDVA 2DFIA 3PKAA 4Z7MA 3RORA 2EVOA 3BIPA 5FCFA 2OAZA 2BWSA 2EVCA 3IU8A 5CNXA 2EVMA 4FLKA 3L24A 1BN5A 2IW2A 3PKEA 4S00A 4IPAA 4R60A 4U6EA 2P99A 4U73A 4U6CA 4FKCA 3IU9A 4IU6A 1WBQA 3TB5A 2Q95A 2GGCA 4U75A 3RVAA 2P98A 3PKCA 3TAVA 1JAWA 2NQ7A 4RZZA 4ZWOA 2B3LA 4OOKA 4S2TP 1C21A 1A16A 4FUKA 1WN1A 3IG4A 4S2RP 2GU6A 1Y1NA 1C24A 1WL9A 2GG2A 2V3XA 4HXXA 1QXWA 2GZ5A 4U6ZA 5CE6A 4RGZ1 4RZYA 4IKUA 4FO8A 4U1BA 2BN7A 5CDEA 4IECA 4U6WA 1YJ3A 4PNCA 2EA4A 2BHAA 4S01A 3CB6A 1R5GA 2BWUA 1PV9A 1XGNA 4U69A 2GG3A 2BWXA 2MATA 2Q93A 2BHBA 4IKRA 1O0XA 3FM3A 4FLJA 4IF7A 1C27A 2BB7A 2GTXA 1R5HA 5JHUA 2GA2A 1WLRA 2OKNA 3MR1A 1KQ9A 4U76A 4U71A 5D6FA 3FMQA 2Q94A 5CLSA 4FLLA 5JFRA 3Q6DA 1W7VA 2GGBA 3L7GA 1B6AA 3MX6A 1N51A 2BWTA 5D6EA 4EGEA 2GG8A 1XNZA 3PKDA 3S6BA 3CB5A 4U70A 2BWVA 2ZSGA 1QZYA 4MATA
chains in the Genus database with same CATH topology
1XGOA 4JUQA 3IU7A 1MATA 3BITA 1M35A 2GG9A 4IDYA 2B3KA 4QR8A 1KP0A 1WY2A 4PV4A 1WKMA 2V3YA 4IKTA 4ZWPA 2V3ZA 2Q8KA 2BWYA 1C23A 1CHMA 1BOAA 1XGMA 1YVMA 1QXZA 1WL6A 4B28A 2GU5A 1R58A 2BH3A 3FMRA 4ZWUA 2HOWA 2GG0A 1W2MA 1YW7A 2Q92A 1YW9A 5FCHA 2P9AA 1B59A 3CTZA 2GG7A 5CIKA 4A6WA 2V6CA 1XGSA 5CDLA 3MATA 3D27A 2Q96A 4FO7A 1C22A 3PKBA 2NQ6A 2EA2A 2GG5A 4IKSA 2G6PA 4FLIA 2ADUA 4A6VA 2BHCA 5JI6A 3BIQA 2GU7A 2BHDA 4ZNGA 2B3HA 2BWWA 1QXYA 1KQ0A 4KM3A 2GU4A 5E5BA 1YW8A 4U6JA 5CDVA 2DFIA 3PKAA 4Z7MA 3RORA 2EVOA 3BIPA 5FCFA 2OAZA 2BWSA 2EVCA 3IU8A 5CNXA 2EVMA 4FLKA 3L24A 1BN5A 2IW2A 3PKEA 4S00A 4IPAA 4R60A 4U6EA 2P99A 4U73A 4U6CA 4FKCA 3IU9A 4IU6A 1WBQA 3TB5A 2Q95A 2GGCA 4U75A 3RVAA 2P98A 3PKCA 3TAVA 1JAWA 2NQ7A 4RZZA 4ZWOA 2B3LA 4OOKA 4S2TP 1C21A 1A16A 4FUKA 1WN1A 3IG4A 4S2RP 2GU6A 1Y1NA 1C24A 1WL9A 2GG2A 2V3XA 4HXXA 1QXWA 2GZ5A 4U6ZA 5CE6A 4RGZ1 4RZYA 4IKUA 4FO8A 4U1BA 2BN7A 5CDEA 4IECA 4U6WA 1YJ3A 4PNCA 2EA4A 2BHAA 4S01A 3CB6A 1R5GA 2BWUA 1PV9A 1XGNA 4U69A 2GG3A 2BWXA 2MATA 2Q93A 2BHBA 4IKRA 1O0XA 3FM3A 4FLJA 4IF7A 1C27A 2BB7A 2GTXA 1R5HA 5JHUA 2GA2A 1WLRA 2OKNA 3MR1A 1KQ9A 4U76A 4U71A 5D6FA 3FMQA 2Q94A 5CLSA 4FLLA 5JFRA 3Q6DA 1W7VA 2GGBA 3L7GA 1B6AA 3MX6A 1N51A 2BWTA 5D6EA 4EGEA 2GG8A 1XNZA 3PKDA 3S6BA 3CB5A 4U70A 2BWVA 2ZSGA 1QZYA 4MATA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1XGO A;  4JUQ A;  3IU7 A;  1MAT A;  3BIT A;  1M35 A;  2GG9 A;  4IDY A;  2B3K A;  4QR8 A;  1KP0 A;  1WY2 A;  4PV4 A;  1WKM A;  2V3Y A;  4IKT A;  4ZWP A;  2V3Z A;  2Q8K A;  2BWY A;  1C23 A;  1CHM A;  1BOA A;  1XGM A;  1YVM A;  1QXZ A;  1WL6 A;  4B28 A;  2GU5 A;  1R58 A;  2BH3 A;  3FMR A;  4ZWU A;  2HOW A;  2GG0 A;  1W2M A;  1YW7 A;  2Q92 A;  1YW9 A;  5FCH A;  2P9A A;  1B59 A;  3CTZ A;  2GG7 A;  5CIK A;  4A6W A;  2V6C A;  1XGS A;  5CDL A;  3MAT A;  3D27 A;  2Q96 A;  4FO7 A;  1C22 A;  3PKB A;  2NQ6 A;  2EA2 A;  2GG5 A;  4IKS A;  2G6P A;  4FLI A;  2ADU A;  4A6V A;  2BHC A;  5JI6 A;  3BIQ A;  2GU7 A;  2BHD A;  4ZNG A;  2B3H A;  2BWW A;  1QXY A;  1KQ0 A;  4KM3 A;  2GU4 A;  5E5B A;  1YW8 A;  4U6J A;  5CDV A;  2DFI A;  3PKA A;  4Z7M A;  3ROR A;  2EVO A;  3BIP A;  5FCF A;  2OAZ A;  2BWS A;  2EVC A;  3IU8 A;  5CNX A;  2EVM A;  4FLK A;  3L24 A;  1BN5 A;  2IW2 A;  3PKE A;  4S00 A;  4IPA A;  4R60 A;  4U6E A;  2P99 A;  4U73 A;  4U6C A;  4FKC A;  3IU9 A;  4IU6 A;  1WBQ A;  3TB5 A;  2Q95 A;  2GGC A;  4U75 A;  3RVA A;  2P98 A;  3PKC A;  3TAV A;  1JAW A;  2NQ7 A;  4RZZ A;  4ZWO A;  2B3L A;  4OOK A;  4S2T P;  1C21 A;  1A16 A;  4FUK A;  1WN1 A;  3IG4 A;  4S2R P;  2GU6 A;  1Y1N A;  1C24 A;  1WL9 A;  2GG2 A;  2V3X A;  4HXX A;  1QXW A;  2GZ5 A;  4U6Z A;  5CE6 A;  4RGZ 1;  4RZY A;  4IKU A;  4FO8 A;  4U1B A;  2BN7 A;  5CDE A;  4IEC A;  4U6W A;  1YJ3 A;  4PNC A;  2EA4 A;  2BHA A;  4S01 A;  3CB6 A;  1R5G A;  2BWU A;  1PV9 A;  1XGN A;  4U69 A;  2GG3 A;  2BWX A;  2MAT A;  2Q93 A;  2BHB A;  4IKR A;  1O0X A;  3FM3 A;  4FLJ A;  4IF7 A;  1C27 A;  2BB7 A;  2GTX A;  1R5H A;  5JHU A;  2GA2 A;  1WLR A;  2OKN A;  3MR1 A;  1KQ9 A;  4U76 A;  4U71 A;  5D6F A;  3FMQ A;  2Q94 A;  5CLS A;  4FLL A;  5JFR A;  3Q6D A;  1W7V A;  2GGB A;  3L7G A;  1B6A A;  3MX6 A;  1N51 A;  2BWT A;  5D6E A;  4EGE A;  2GG8 A;  1XNZ A;  3PKD A;  3S6B A;  3CB5 A;  4U70 A;  2BWV A;  2ZSG A;  1QZY A;  4MAT A; 
#chains in the Genus database with same CATH topology
 1XGO A;  4JUQ A;  3IU7 A;  1MAT A;  3BIT A;  1M35 A;  2GG9 A;  4IDY A;  2B3K A;  4QR8 A;  1KP0 A;  1WY2 A;  4PV4 A;  1WKM A;  2V3Y A;  4IKT A;  4ZWP A;  2V3Z A;  2Q8K A;  2BWY A;  1C23 A;  1CHM A;  1BOA A;  1XGM A;  1YVM A;  1QXZ A;  1WL6 A;  4B28 A;  2GU5 A;  1R58 A;  2BH3 A;  3FMR A;  4ZWU A;  2HOW A;  2GG0 A;  1W2M A;  1YW7 A;  2Q92 A;  1YW9 A;  5FCH A;  2P9A A;  1B59 A;  3CTZ A;  2GG7 A;  5CIK A;  4A6W A;  2V6C A;  1XGS A;  5CDL A;  3MAT A;  3D27 A;  2Q96 A;  4FO7 A;  1C22 A;  3PKB A;  2NQ6 A;  2EA2 A;  2GG5 A;  4IKS A;  2G6P A;  4FLI A;  2ADU A;  4A6V A;  2BHC A;  5JI6 A;  3BIQ A;  2GU7 A;  2BHD A;  4ZNG A;  2B3H A;  2BWW A;  1QXY A;  1KQ0 A;  4KM3 A;  2GU4 A;  5E5B A;  1YW8 A;  4U6J A;  5CDV A;  2DFI A;  3PKA A;  4Z7M A;  3ROR A;  2EVO A;  3BIP A;  5FCF A;  2OAZ A;  2BWS A;  2EVC A;  3IU8 A;  5CNX A;  2EVM A;  4FLK A;  3L24 A;  1BN5 A;  2IW2 A;  3PKE A;  4S00 A;  4IPA A;  4R60 A;  4U6E A;  2P99 A;  4U73 A;  4U6C A;  4FKC A;  3IU9 A;  4IU6 A;  1WBQ A;  3TB5 A;  2Q95 A;  2GGC A;  4U75 A;  3RVA A;  2P98 A;  3PKC A;  3TAV A;  1JAW A;  2NQ7 A;  4RZZ A;  4ZWO A;  2B3L A;  4OOK A;  4S2T P;  1C21 A;  1A16 A;  4FUK A;  1WN1 A;  3IG4 A;  4S2R P;  2GU6 A;  1Y1N A;  1C24 A;  1WL9 A;  2GG2 A;  2V3X A;  4HXX A;  1QXW A;  2GZ5 A;  4U6Z A;  5CE6 A;  4RGZ 1;  4RZY A;  4IKU A;  4FO8 A;  4U1B A;  2BN7 A;  5CDE A;  4IEC A;  4U6W A;  1YJ3 A;  4PNC A;  2EA4 A;  2BHA A;  4S01 A;  3CB6 A;  1R5G A;  2BWU A;  1PV9 A;  1XGN A;  4U69 A;  2GG3 A;  2BWX A;  2MAT A;  2Q93 A;  2BHB A;  4IKR A;  1O0X A;  3FM3 A;  4FLJ A;  4IF7 A;  1C27 A;  2BB7 A;  2GTX A;  1R5H A;  5JHU A;  2GA2 A;  1WLR A;  2OKN A;  3MR1 A;  1KQ9 A;  4U76 A;  4U71 A;  5D6F A;  3FMQ A;  2Q94 A;  5CLS A;  4FLL A;  5JFR A;  3Q6D A;  1W7V A;  2GGB A;  3L7G A;  1B6A A;  3MX6 A;  1N51 A;  2BWT A;  5D6E A;  4EGE A;  2GG8 A;  1XNZ A;  3PKD A;  3S6B A;  3CB5 A;  4U70 A;  2BWV A;  2ZSG A;  1QZY A;  4MAT A; 
#chains in the Genus database with same CATH homology
 1XGO A;  4JUQ A;  3IU7 A;  1MAT A;  3BIT A;  1M35 A;  2GG9 A;  4IDY A;  2B3K A;  4QR8 A;  1KP0 A;  1WY2 A;  4PV4 A;  1WKM A;  2V3Y A;  4IKT A;  4ZWP A;  2V3Z A;  2Q8K A;  2BWY A;  1C23 A;  1CHM A;  1BOA A;  1XGM A;  1YVM A;  1QXZ A;  1WL6 A;  4B28 A;  2GU5 A;  1R58 A;  2BH3 A;  3FMR A;  4ZWU A;  2HOW A;  2GG0 A;  1W2M A;  1YW7 A;  2Q92 A;  1YW9 A;  5FCH A;  2P9A A;  1B59 A;  3CTZ A;  2GG7 A;  5CIK A;  4A6W A;  2V6C A;  1XGS A;  5CDL A;  3MAT A;  3D27 A;  2Q96 A;  4FO7 A;  1C22 A;  3PKB A;  2NQ6 A;  2EA2 A;  2GG5 A;  4IKS A;  2G6P A;  4FLI A;  2ADU A;  4A6V A;  2BHC A;  5JI6 A;  3BIQ A;  2GU7 A;  2BHD A;  4ZNG A;  2B3H A;  2BWW A;  1QXY A;  1KQ0 A;  4KM3 A;  2GU4 A;  5E5B A;  1YW8 A;  4U6J A;  5CDV A;  2DFI A;  3PKA A;  4Z7M A;  3ROR A;  2EVO A;  3BIP A;  5FCF A;  2OAZ A;  2BWS A;  2EVC A;  3IU8 A;  5CNX A;  2EVM A;  4FLK A;  3L24 A;  1BN5 A;  2IW2 A;  3PKE A;  4S00 A;  4IPA A;  4R60 A;  4U6E A;  2P99 A;  4U73 A;  4U6C A;  4FKC A;  3IU9 A;  4IU6 A;  1WBQ A;  3TB5 A;  2Q95 A;  2GGC A;  4U75 A;  3RVA A;  2P98 A;  3PKC A;  3TAV A;  1JAW A;  2NQ7 A;  4RZZ A;  4ZWO A;  2B3L A;  4OOK A;  4S2T P;  1C21 A;  1A16 A;  4FUK A;  1WN1 A;  3IG4 A;  4S2R P;  2GU6 A;  1Y1N A;  1C24 A;  1WL9 A;  2GG2 A;  2V3X A;  4HXX A;  1QXW A;  2GZ5 A;  4U6Z A;  5CE6 A;  4RGZ 1;  4RZY A;  4IKU A;  4FO8 A;  4U1B A;  2BN7 A;  5CDE A;  4IEC A;  4U6W A;  1YJ3 A;  4PNC A;  2EA4 A;  2BHA A;  4S01 A;  3CB6 A;  1R5G A;  2BWU A;  1PV9 A;  1XGN A;  4U69 A;  2GG3 A;  2BWX A;  2MAT A;  2Q93 A;  2BHB A;  4IKR A;  1O0X A;  3FM3 A;  4FLJ A;  4IF7 A;  1C27 A;  2BB7 A;  2GTX A;  1R5H A;  5JHU A;  2GA2 A;  1WLR A;  2OKN A;  3MR1 A;  1KQ9 A;  4U76 A;  4U71 A;  5D6F A;  3FMQ A;  2Q94 A;  5CLS A;  4FLL A;  5JFR A;  3Q6D A;  1W7V A;  2GGB A;  3L7G A;  1B6A A;  3MX6 A;  1N51 A;  2BWT A;  5D6E A;  4EGE A;  2GG8 A;  1XNZ A;  3PKD A;  3S6B A;  3CB5 A;  4U70 A;  2BWV A;  2ZSG A;  1QZY A;  4MAT A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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