2GG9A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli k12
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 86
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg9A00
2V3ZA 3S6BA 3IU9A 2GZ5A 5CDVA 2P98A 2BWUA 1C21A 1XGNA 2GG8A 1QZYA 3L24A 3PKCA 2BHAA 4U76A 2BN7A 2B3KA 3PKDA 4IKTA 4U70A 1YW7A 2BWXA 4EGEA 1BN5A 4IF7A 1QXZA 2V3XA 4IDYA 2BH3A 5D6FA 2P9AA 5CE6A 2NQ7A 1W7VA 2MATA 5FCHA 3MATA 4U1BA 1W2MA 4IKRA 4ZWOA 3BIQA 2GU6A 4RGZ1 4Z7MA 4HXXA 1C23A 3PKBA 4U73A 5CLSA 1WL6A 4U6WA 4IKUA 5D6EA 1WN1A 3IG4A 2OKNA 3BITA 3BIPA 1KQ0A 4U69A 1C27A 2ZSGA 2BWYA 3Q6DA 1R5GA 4FO8A 2GTXA 1M35A 4U75A 4U71A 5CIKA 5JFRA 1C24A 2GG0A 1Y1NA 1YW9A 3IU7A 2EVOA 3RVAA 5E5BA 4FLLA 3CB6A 2BHBA 4PV4A 4U6ZA 2HOWA 4FUKA 4KM3A 4U6CA 2ADUA 2BHDA 4S2TP 2GG3A 4JUQA 1A16A 4S00A 1R5HA 4FKCA 3L7GA 1WKMA 2Q93A 2GU4A 2EVMA 1XGMA 1YJ3A 4FO7A 4B28A 3MX6A 2GG7A 4QR8A 3IU8A 4A6WA 2GU5A 4RZZA 1WY2A 2V6CA 2BHCA 3CB5A 2NQ6A 2GG2A 3CTZA 3PKAA 1C22A 3D27A 5JI6A 2B3LA 2DFIA 4IECA 1BOAA 2BWVA 3FM3A 4R60A 5CDEA 1QXYA 4PNCA 1XGOA 3FMRA 4IPAA 4ZWUA 3TAVA 4U6JA 4FLIA 4IKSA 4ZWPA 1XNZA 1B6AA 2GA2A 2GGBA 2OAZA 3FMQA 3MR1A 4RZYA 4S2RP 2EA4A 4A6VA 2GGCA 2V3YA 2G6PA 4FLKA 2Q92A 4ZNGA 1KP0A 1O0XA 2EA2A 3RORA 1B59A 1CHMA 1YVMA 4FLJA 2BB7A 1JAWA 2BWWA 4IU6A 5FCFA 5CNXA 1R58A 5JHUA 1PV9A 2IW2A 1WL9A 2Q94A 1WBQA 2BWSA 2GU7A 4S01A 4U6EA 5CDLA 4OOKA 3TB5A 2BWTA 1YW8A 1QXWA 2EVCA 3PKEA 2Q95A 2Q8KA 2P99A 1KQ9A 2Q96A 2GG9A 1N51A 2B3HA 1MATA 1WLRA 1XGSA 4MATA 2GG5A
chains in the Genus database with same CATH superfamily
2V3ZA 3S6BA 3IU9A 2GZ5A 5CDVA 2P98A 2BWUA 1C21A 1XGNA 2GG8A 1QZYA 3L24A 3PKCA 2BHAA 4U76A 2BN7A 2B3KA 3PKDA 4IKTA 4U70A 1YW7A 2BWXA 4EGEA 1BN5A 4IF7A 1QXZA 2V3XA 4IDYA 2BH3A 5D6FA 2P9AA 5CE6A 2NQ7A 1W7VA 2MATA 5FCHA 3MATA 4U1BA 1W2MA 4IKRA 4ZWOA 3BIQA 2GU6A 4RGZ1 4Z7MA 4HXXA 1C23A 3PKBA 4U73A 5CLSA 1WL6A 4U6WA 4IKUA 5D6EA 1WN1A 3IG4A 2OKNA 3BITA 3BIPA 1KQ0A 4U69A 1C27A 2ZSGA 2BWYA 3Q6DA 1R5GA 4FO8A 2GTXA 1M35A 4U75A 4U71A 5CIKA 5JFRA 1C24A 2GG0A 1Y1NA 1YW9A 3IU7A 2EVOA 3RVAA 5E5BA 4FLLA 3CB6A 2BHBA 4PV4A 4U6ZA 2HOWA 4FUKA 4KM3A 4U6CA 2ADUA 2BHDA 4S2TP 2GG3A 4JUQA 1A16A 4S00A 1R5HA 4FKCA 3L7GA 1WKMA 2Q93A 2GU4A 2EVMA 1XGMA 1YJ3A 4FO7A 4B28A 3MX6A 2GG7A 4QR8A 3IU8A 4A6WA 2GU5A 4RZZA 1WY2A 2V6CA 2BHCA 3CB5A 2NQ6A 2GG2A 3CTZA 3PKAA 1C22A 3D27A 5JI6A 2B3LA 2DFIA 4IECA 1BOAA 2BWVA 3FM3A 4R60A 5CDEA 1QXYA 4PNCA 1XGOA 3FMRA 4IPAA 4ZWUA 3TAVA 4U6JA 4FLIA 4IKSA 4ZWPA 1XNZA 1B6AA 2GA2A 2GGBA 2OAZA 3FMQA 3MR1A 4RZYA 4S2RP 2EA4A 4A6VA 2GGCA 2V3YA 2G6PA 4FLKA 2Q92A 4ZNGA 1KP0A 1O0XA 2EA2A 3RORA 1B59A 1CHMA 1YVMA 4FLJA 2BB7A 1JAWA 2BWWA 4IU6A 5FCFA 5CNXA 1R58A 5JHUA 1PV9A 2IW2A 1WL9A 2Q94A 1WBQA 2BWSA 2GU7A 4S01A 4U6EA 5CDLA 4OOKA 3TB5A 2BWTA 1YW8A 1QXWA 2EVCA 3PKEA 2Q95A 2Q8KA 2P99A 1KQ9A 2Q96A 2GG9A 1N51A 2B3HA 1MATA 1WLRA 1XGSA 4MATA 2GG5A
chains in the Genus database with same CATH topology
2V3ZA 3S6BA 3IU9A 2GZ5A 5CDVA 2P98A 2BWUA 1C21A 1XGNA 2GG8A 1QZYA 3L24A 3PKCA 2BHAA 4U76A 2BN7A 2B3KA 3PKDA 4IKTA 4U70A 1YW7A 2BWXA 4EGEA 1BN5A 4IF7A 1QXZA 2V3XA 4IDYA 2BH3A 5D6FA 2P9AA 5CE6A 2NQ7A 1W7VA 2MATA 5FCHA 3MATA 4U1BA 1W2MA 4IKRA 4ZWOA 3BIQA 2GU6A 4RGZ1 4Z7MA 4HXXA 1C23A 3PKBA 4U73A 5CLSA 1WL6A 4U6WA 4IKUA 5D6EA 1WN1A 3IG4A 2OKNA 3BITA 3BIPA 1KQ0A 4U69A 1C27A 2ZSGA 2BWYA 3Q6DA 1R5GA 4FO8A 2GTXA 1M35A 4U75A 4U71A 5CIKA 5JFRA 1C24A 2GG0A 1Y1NA 1YW9A 3IU7A 2EVOA 3RVAA 5E5BA 4FLLA 3CB6A 2BHBA 4PV4A 4U6ZA 2HOWA 4FUKA 4KM3A 4U6CA 2ADUA 2BHDA 4S2TP 2GG3A 4JUQA 1A16A 4S00A 1R5HA 4FKCA 3L7GA 1WKMA 2Q93A 2GU4A 2EVMA 1XGMA 1YJ3A 4FO7A 4B28A 3MX6A 2GG7A 4QR8A 3IU8A 4A6WA 2GU5A 4RZZA 1WY2A 2V6CA 2BHCA 3CB5A 2NQ6A 2GG2A 3CTZA 3PKAA 1C22A 3D27A 5JI6A 2B3LA 2DFIA 4IECA 1BOAA 2BWVA 3FM3A 4R60A 5CDEA 1QXYA 4PNCA 1XGOA 3FMRA 4IPAA 4ZWUA 3TAVA 4U6JA 4FLIA 4IKSA 4ZWPA 1XNZA 1B6AA 2GA2A 2GGBA 2OAZA 3FMQA 3MR1A 4RZYA 4S2RP 2EA4A 4A6VA 2GGCA 2V3YA 2G6PA 4FLKA 2Q92A 4ZNGA 1KP0A 1O0XA 2EA2A 3RORA 1B59A 1CHMA 1YVMA 4FLJA 2BB7A 1JAWA 2BWWA 4IU6A 5FCFA 5CNXA 1R58A 5JHUA 1PV9A 2IW2A 1WL9A 2Q94A 1WBQA 2BWSA 2GU7A 4S01A 4U6EA 5CDLA 4OOKA 3TB5A 2BWTA 1YW8A 1QXWA 2EVCA 3PKEA 2Q95A 2Q8KA 2P99A 1KQ9A 2Q96A 2GG9A 1N51A 2B3HA 1MATA 1WLRA 1XGSA 4MATA 2GG5A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2V3Z A;  3S6B A;  3IU9 A;  2GZ5 A;  5CDV A;  2P98 A;  2BWU A;  1C21 A;  1XGN A;  2GG8 A;  1QZY A;  3L24 A;  3PKC A;  2BHA A;  4U76 A;  2BN7 A;  2B3K A;  3PKD A;  4IKT A;  4U70 A;  1YW7 A;  2BWX A;  4EGE A;  1BN5 A;  4IF7 A;  1QXZ A;  2V3X A;  4IDY A;  2BH3 A;  5D6F A;  2P9A A;  5CE6 A;  2NQ7 A;  1W7V A;  2MAT A;  5FCH A;  3MAT A;  4U1B A;  1W2M A;  4IKR A;  4ZWO A;  3BIQ A;  2GU6 A;  4RGZ 1;  4Z7M A;  4HXX A;  1C23 A;  3PKB A;  4U73 A;  5CLS A;  1WL6 A;  4U6W A;  4IKU A;  5D6E A;  1WN1 A;  3IG4 A;  2OKN A;  3BIT A;  3BIP A;  1KQ0 A;  4U69 A;  1C27 A;  2ZSG A;  2BWY A;  3Q6D A;  1R5G A;  4FO8 A;  2GTX A;  1M35 A;  4U75 A;  4U71 A;  5CIK A;  5JFR A;  1C24 A;  2GG0 A;  1Y1N A;  1YW9 A;  3IU7 A;  2EVO A;  3RVA A;  5E5B A;  4FLL A;  3CB6 A;  2BHB A;  4PV4 A;  4U6Z A;  2HOW A;  4FUK A;  4KM3 A;  4U6C A;  2ADU A;  2BHD A;  4S2T P;  2GG3 A;  4JUQ A;  1A16 A;  4S00 A;  1R5H A;  4FKC A;  3L7G A;  1WKM A;  2Q93 A;  2GU4 A;  2EVM A;  1XGM A;  1YJ3 A;  4FO7 A;  4B28 A;  3MX6 A;  2GG7 A;  4QR8 A;  3IU8 A;  4A6W A;  2GU5 A;  4RZZ A;  1WY2 A;  2V6C A;  2BHC A;  3CB5 A;  2NQ6 A;  2GG2 A;  3CTZ A;  3PKA A;  1C22 A;  3D27 A;  5JI6 A;  2B3L A;  2DFI A;  4IEC A;  1BOA A;  2BWV A;  3FM3 A;  4R60 A;  5CDE A;  1QXY A;  4PNC A;  1XGO A;  3FMR A;  4IPA A;  4ZWU A;  3TAV A;  4U6J A;  4FLI A;  4IKS A;  4ZWP A;  1XNZ A;  1B6A A;  2GA2 A;  2GGB A;  2OAZ A;  3FMQ A;  3MR1 A;  4RZY A;  4S2R P;  2EA4 A;  4A6V A;  2GGC A;  2V3Y A;  2G6P A;  4FLK A;  2Q92 A;  4ZNG A;  1KP0 A;  1O0X A;  2EA2 A;  3ROR A;  1B59 A;  1CHM A;  1YVM A;  4FLJ A;  2BB7 A;  1JAW A;  2BWW A;  4IU6 A;  5FCF A;  5CNX A;  1R58 A;  5JHU A;  1PV9 A;  2IW2 A;  1WL9 A;  2Q94 A;  1WBQ A;  2BWS A;  2GU7 A;  4S01 A;  4U6E A;  5CDL A;  4OOK A;  3TB5 A;  2BWT A;  1YW8 A;  1QXW A;  2EVC A;  3PKE A;  2Q95 A;  2Q8K A;  2P99 A;  1KQ9 A;  2Q96 A;  2GG9 A;  1N51 A;  2B3H A;  1MAT A;  1WLR A;  1XGS A;  4MAT A;  2GG5 A; 
#chains in the Genus database with same CATH topology
 2V3Z A;  3S6B A;  3IU9 A;  2GZ5 A;  5CDV A;  2P98 A;  2BWU A;  1C21 A;  1XGN A;  2GG8 A;  1QZY A;  3L24 A;  3PKC A;  2BHA A;  4U76 A;  2BN7 A;  2B3K A;  3PKD A;  4IKT A;  4U70 A;  1YW7 A;  2BWX A;  4EGE A;  1BN5 A;  4IF7 A;  1QXZ A;  2V3X A;  4IDY A;  2BH3 A;  5D6F A;  2P9A A;  5CE6 A;  2NQ7 A;  1W7V A;  2MAT A;  5FCH A;  3MAT A;  4U1B A;  1W2M A;  4IKR A;  4ZWO A;  3BIQ A;  2GU6 A;  4RGZ 1;  4Z7M A;  4HXX A;  1C23 A;  3PKB A;  4U73 A;  5CLS A;  1WL6 A;  4U6W A;  4IKU A;  5D6E A;  1WN1 A;  3IG4 A;  2OKN A;  3BIT A;  3BIP A;  1KQ0 A;  4U69 A;  1C27 A;  2ZSG A;  2BWY A;  3Q6D A;  1R5G A;  4FO8 A;  2GTX A;  1M35 A;  4U75 A;  4U71 A;  5CIK A;  5JFR A;  1C24 A;  2GG0 A;  1Y1N A;  1YW9 A;  3IU7 A;  2EVO A;  3RVA A;  5E5B A;  4FLL A;  3CB6 A;  2BHB A;  4PV4 A;  4U6Z A;  2HOW A;  4FUK A;  4KM3 A;  4U6C A;  2ADU A;  2BHD A;  4S2T P;  2GG3 A;  4JUQ A;  1A16 A;  4S00 A;  1R5H A;  4FKC A;  3L7G A;  1WKM A;  2Q93 A;  2GU4 A;  2EVM A;  1XGM A;  1YJ3 A;  4FO7 A;  4B28 A;  3MX6 A;  2GG7 A;  4QR8 A;  3IU8 A;  4A6W A;  2GU5 A;  4RZZ A;  1WY2 A;  2V6C A;  2BHC A;  3CB5 A;  2NQ6 A;  2GG2 A;  3CTZ A;  3PKA A;  1C22 A;  3D27 A;  5JI6 A;  2B3L A;  2DFI A;  4IEC A;  1BOA A;  2BWV A;  3FM3 A;  4R60 A;  5CDE A;  1QXY A;  4PNC A;  1XGO A;  3FMR A;  4IPA A;  4ZWU A;  3TAV A;  4U6J A;  4FLI A;  4IKS A;  4ZWP A;  1XNZ A;  1B6A A;  2GA2 A;  2GGB A;  2OAZ A;  3FMQ A;  3MR1 A;  4RZY A;  4S2R P;  2EA4 A;  4A6V A;  2GGC A;  2V3Y A;  2G6P A;  4FLK A;  2Q92 A;  4ZNG A;  1KP0 A;  1O0X A;  2EA2 A;  3ROR A;  1B59 A;  1CHM A;  1YVM A;  4FLJ A;  2BB7 A;  1JAW A;  2BWW A;  4IU6 A;  5FCF A;  5CNX A;  1R58 A;  5JHU A;  1PV9 A;  2IW2 A;  1WL9 A;  2Q94 A;  1WBQ A;  2BWS A;  2GU7 A;  4S01 A;  4U6E A;  5CDL A;  4OOK A;  3TB5 A;  2BWT A;  1YW8 A;  1QXW A;  2EVC A;  3PKE A;  2Q95 A;  2Q8K A;  2P99 A;  1KQ9 A;  2Q96 A;  2GG9 A;  1N51 A;  2B3H A;  1MAT A;  1WLR A;  1XGS A;  4MAT A;  2GG5 A; 
#chains in the Genus database with same CATH homology
 2V3Z A;  3S6B A;  3IU9 A;  2GZ5 A;  5CDV A;  2P98 A;  2BWU A;  1C21 A;  1XGN A;  2GG8 A;  1QZY A;  3L24 A;  3PKC A;  2BHA A;  4U76 A;  2BN7 A;  2B3K A;  3PKD A;  4IKT A;  4U70 A;  1YW7 A;  2BWX A;  4EGE A;  1BN5 A;  4IF7 A;  1QXZ A;  2V3X A;  4IDY A;  2BH3 A;  5D6F A;  2P9A A;  5CE6 A;  2NQ7 A;  1W7V A;  2MAT A;  5FCH A;  3MAT A;  4U1B A;  1W2M A;  4IKR A;  4ZWO A;  3BIQ A;  2GU6 A;  4RGZ 1;  4Z7M A;  4HXX A;  1C23 A;  3PKB A;  4U73 A;  5CLS A;  1WL6 A;  4U6W A;  4IKU A;  5D6E A;  1WN1 A;  3IG4 A;  2OKN A;  3BIT A;  3BIP A;  1KQ0 A;  4U69 A;  1C27 A;  2ZSG A;  2BWY A;  3Q6D A;  1R5G A;  4FO8 A;  2GTX A;  1M35 A;  4U75 A;  4U71 A;  5CIK A;  5JFR A;  1C24 A;  2GG0 A;  1Y1N A;  1YW9 A;  3IU7 A;  2EVO A;  3RVA A;  5E5B A;  4FLL A;  3CB6 A;  2BHB A;  4PV4 A;  4U6Z A;  2HOW A;  4FUK A;  4KM3 A;  4U6C A;  2ADU A;  2BHD A;  4S2T P;  2GG3 A;  4JUQ A;  1A16 A;  4S00 A;  1R5H A;  4FKC A;  3L7G A;  1WKM A;  2Q93 A;  2GU4 A;  2EVM A;  1XGM A;  1YJ3 A;  4FO7 A;  4B28 A;  3MX6 A;  2GG7 A;  4QR8 A;  3IU8 A;  4A6W A;  2GU5 A;  4RZZ A;  1WY2 A;  2V6C A;  2BHC A;  3CB5 A;  2NQ6 A;  2GG2 A;  3CTZ A;  3PKA A;  1C22 A;  3D27 A;  5JI6 A;  2B3L A;  2DFI A;  4IEC A;  1BOA A;  2BWV A;  3FM3 A;  4R60 A;  5CDE A;  1QXY A;  4PNC A;  1XGO A;  3FMR A;  4IPA A;  4ZWU A;  3TAV A;  4U6J A;  4FLI A;  4IKS A;  4ZWP A;  1XNZ A;  1B6A A;  2GA2 A;  2GGB A;  2OAZ A;  3FMQ A;  3MR1 A;  4RZY A;  4S2R P;  2EA4 A;  4A6V A;  2GGC A;  2V3Y A;  2G6P A;  4FLK A;  2Q92 A;  4ZNG A;  1KP0 A;  1O0X A;  2EA2 A;  3ROR A;  1B59 A;  1CHM A;  1YVM A;  4FLJ A;  2BB7 A;  1JAW A;  2BWW A;  4IU6 A;  5FCF A;  5CNX A;  1R58 A;  5JHU A;  1PV9 A;  2IW2 A;  1WL9 A;  2Q94 A;  1WBQ A;  2BWS A;  2GU7 A;  4S01 A;  4U6E A;  5CDL A;  4OOK A;  3TB5 A;  2BWT A;  1YW8 A;  1QXW A;  2EVC A;  3PKE A;  2Q95 A;  2Q8K A;  2P99 A;  1KQ9 A;  2Q96 A;  2GG9 A;  1N51 A;  2B3H A;  1MAT A;  1WLR A;  1XGS A;  4MAT A;  2GG5 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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