4U6JA

Hsmetap in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6jA00
4ZWOA 5CNXA 5D6FA 3TB5A 1R5GA 1C27A 2BWTA 1W2MA 2BHBA 3IU7A 1B6AA 4U76A 4ZWUA 2Q94A 1XNZA 4PV4A 2BHDA 2P98A 2B3KA 2BHAA 1N51A 4FKCA 2IW2A 4FLJA 4ZWPA 5CDEA 4IKRA 1C21A 3Q6DA 1R58A 4U69A 2BH3A 2GG8A 3PKAA 1QXYA 1C23A 2HOWA 5E5BA 1WKMA 3TAVA 2GA2A 4HXXA 4IPAA 4U73A 4B28A 2GG2A 5JI6A 3MR1A 4FO7A 3CB5A 4U6ZA 4EGEA 4A6VA 1KQ0A 4U70A 3MX6A 4FLKA 2OAZA 2B3LA 1R5HA 4IF7A 2DFIA 2GU6A 2V3ZA 4FLLA 1W7VA 1QXZA 5FCHA 3PKCA 2BWWA 4JUQA 5CE6A 2B3HA 2EA4A 3CTZA 2GU5A 1WBQA 2Q92A 5CIKA 1YW9A 4S00A 2GTXA 2P99A 2GG5A 1XGMA 2EVMA 3FM3A 2GG7A 4MATA 2P9AA 4U75A 4A6WA 2GG0A 2V3YA 4OOKA 1XGNA 1WL9A 2ADUA 4ZNGA 2BHCA 3IU8A 2OKNA 1BN5A 4FUKA 5CLSA 4RZZA 1O0XA 1YW8A 2GG3A 2GZ5A 2Q95A 4IDYA 4U6CA 5JHUA 1WLRA 1QZYA 5D6EA 2GU7A 2GU4A 1WL6A 3BIQA 1Y1NA 2V3XA 2GG9A 1BOAA 1YW7A 2EVOA 2Q8KA 1MATA 3FMRA 4U6WA 4FLIA 1C24A 4IECA 4IU6A 4S2RP 4U6JA 2BWXA 1XGOA 2Q93A 3L7GA 1CHMA 3MATA 4Z7MA 5JFRA 5CDLA 3IG4A 1YVMA 1PV9A 3D27A 3RVAA 4FO8A 2NQ7A 1M35A 5CDVA 4IKTA 1JAWA 4U6EA 2BWSA 2GGBA 1C22A 2GGCA 2NQ6A 2EVCA 2BWVA 2BWUA 1KP0A 2G6PA 2V6CA 3CB6A 3PKDA 1B59A 4PNCA 3BITA 2BN7A 2EA2A 3PKBA 4KM3A 4S2TP 3RORA 2BB7A 1XGSA 1WN1A 2MATA 4IKSA 4S01A 3FMQA 3BIPA 2Q96A 1QXWA 3PKEA 4U1BA 4RGZ1 5FCFA 4IKUA 1KQ9A 1A16A 1YJ3A 2BWYA 4RZYA 2ZSGA 3L24A 4U71A 4R60A 1WY2A 3S6BA 3IU9A 4QR8A
chains in the Genus database with same CATH superfamily
4ZWOA 5CNXA 5D6FA 3TB5A 1R5GA 1C27A 2BWTA 1W2MA 2BHBA 3IU7A 1B6AA 4U76A 4ZWUA 2Q94A 1XNZA 4PV4A 2BHDA 2P98A 2B3KA 2BHAA 1N51A 4FKCA 2IW2A 4FLJA 4ZWPA 5CDEA 4IKRA 1C21A 3Q6DA 1R58A 4U69A 2BH3A 2GG8A 3PKAA 1QXYA 1C23A 2HOWA 5E5BA 1WKMA 3TAVA 2GA2A 4HXXA 4IPAA 4U73A 4B28A 2GG2A 5JI6A 3MR1A 4FO7A 3CB5A 4U6ZA 4EGEA 4A6VA 1KQ0A 4U70A 3MX6A 4FLKA 2OAZA 2B3LA 1R5HA 4IF7A 2DFIA 2GU6A 2V3ZA 4FLLA 1W7VA 1QXZA 5FCHA 3PKCA 2BWWA 4JUQA 5CE6A 2B3HA 2EA4A 3CTZA 2GU5A 1WBQA 2Q92A 5CIKA 1YW9A 4S00A 2GTXA 2P99A 2GG5A 1XGMA 2EVMA 3FM3A 2GG7A 4MATA 2P9AA 4U75A 4A6WA 2GG0A 2V3YA 4OOKA 1XGNA 1WL9A 2ADUA 4ZNGA 2BHCA 3IU8A 2OKNA 1BN5A 4FUKA 5CLSA 4RZZA 1O0XA 1YW8A 2GG3A 2GZ5A 2Q95A 4IDYA 4U6CA 5JHUA 1WLRA 1QZYA 5D6EA 2GU7A 2GU4A 1WL6A 3BIQA 1Y1NA 2V3XA 2GG9A 1BOAA 1YW7A 2EVOA 2Q8KA 1MATA 3FMRA 4U6WA 4FLIA 1C24A 4IECA 4IU6A 4S2RP 4U6JA 2BWXA 1XGOA 2Q93A 3L7GA 1CHMA 3MATA 4Z7MA 5JFRA 5CDLA 3IG4A 1YVMA 1PV9A 3D27A 3RVAA 4FO8A 2NQ7A 1M35A 5CDVA 4IKTA 1JAWA 4U6EA 2BWSA 2GGBA 1C22A 2GGCA 2NQ6A 2EVCA 2BWVA 2BWUA 1KP0A 2G6PA 2V6CA 3CB6A 3PKDA 1B59A 4PNCA 3BITA 2BN7A 2EA2A 3PKBA 4KM3A 4S2TP 3RORA 2BB7A 1XGSA 1WN1A 2MATA 4IKSA 4S01A 3FMQA 3BIPA 2Q96A 1QXWA 3PKEA 4U1BA 4RGZ1 5FCFA 4IKUA 1KQ9A 1A16A 1YJ3A 2BWYA 4RZYA 2ZSGA 3L24A 4U71A 4R60A 1WY2A 3S6BA 3IU9A 4QR8A
chains in the Genus database with same CATH topology
4ZWOA 5CNXA 5D6FA 3TB5A 1R5GA 1C27A 2BWTA 1W2MA 2BHBA 3IU7A 1B6AA 4U76A 4ZWUA 2Q94A 1XNZA 4PV4A 2BHDA 2P98A 2B3KA 2BHAA 1N51A 4FKCA 2IW2A 4FLJA 4ZWPA 5CDEA 4IKRA 1C21A 3Q6DA 1R58A 4U69A 2BH3A 2GG8A 3PKAA 1QXYA 1C23A 2HOWA 5E5BA 1WKMA 3TAVA 2GA2A 4HXXA 4IPAA 4U73A 4B28A 2GG2A 5JI6A 3MR1A 4FO7A 3CB5A 4U6ZA 4EGEA 4A6VA 1KQ0A 4U70A 3MX6A 4FLKA 2OAZA 2B3LA 1R5HA 4IF7A 2DFIA 2GU6A 2V3ZA 4FLLA 1W7VA 1QXZA 5FCHA 3PKCA 2BWWA 4JUQA 5CE6A 2B3HA 2EA4A 3CTZA 2GU5A 1WBQA 2Q92A 5CIKA 1YW9A 4S00A 2GTXA 2P99A 2GG5A 1XGMA 2EVMA 3FM3A 2GG7A 4MATA 2P9AA 4U75A 4A6WA 2GG0A 2V3YA 4OOKA 1XGNA 1WL9A 2ADUA 4ZNGA 2BHCA 3IU8A 2OKNA 1BN5A 4FUKA 5CLSA 4RZZA 1O0XA 1YW8A 2GG3A 2GZ5A 2Q95A 4IDYA 4U6CA 5JHUA 1WLRA 1QZYA 5D6EA 2GU7A 2GU4A 1WL6A 3BIQA 1Y1NA 2V3XA 2GG9A 1BOAA 1YW7A 2EVOA 2Q8KA 1MATA 3FMRA 4U6WA 4FLIA 1C24A 4IECA 4IU6A 4S2RP 4U6JA 2BWXA 1XGOA 2Q93A 3L7GA 1CHMA 3MATA 4Z7MA 5JFRA 5CDLA 3IG4A 1YVMA 1PV9A 3D27A 3RVAA 4FO8A 2NQ7A 1M35A 5CDVA 4IKTA 1JAWA 4U6EA 2BWSA 2GGBA 1C22A 2GGCA 2NQ6A 2EVCA 2BWVA 2BWUA 1KP0A 2G6PA 2V6CA 3CB6A 3PKDA 1B59A 4PNCA 3BITA 2BN7A 2EA2A 3PKBA 4KM3A 4S2TP 3RORA 2BB7A 1XGSA 1WN1A 2MATA 4IKSA 4S01A 3FMQA 3BIPA 2Q96A 1QXWA 3PKEA 4U1BA 4RGZ1 5FCFA 4IKUA 1KQ9A 1A16A 1YJ3A 2BWYA 4RZYA 2ZSGA 3L24A 4U71A 4R60A 1WY2A 3S6BA 3IU9A 4QR8A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4ZWO A;  5CNX A;  5D6F A;  3TB5 A;  1R5G A;  1C27 A;  2BWT A;  1W2M A;  2BHB A;  3IU7 A;  1B6A A;  4U76 A;  4ZWU A;  2Q94 A;  1XNZ A;  4PV4 A;  2BHD A;  2P98 A;  2B3K A;  2BHA A;  1N51 A;  4FKC A;  2IW2 A;  4FLJ A;  4ZWP A;  5CDE A;  4IKR A;  1C21 A;  3Q6D A;  1R58 A;  4U69 A;  2BH3 A;  2GG8 A;  3PKA A;  1QXY A;  1C23 A;  2HOW A;  5E5B A;  1WKM A;  3TAV A;  2GA2 A;  4HXX A;  4IPA A;  4U73 A;  4B28 A;  2GG2 A;  5JI6 A;  3MR1 A;  4FO7 A;  3CB5 A;  4U6Z A;  4EGE A;  4A6V A;  1KQ0 A;  4U70 A;  3MX6 A;  4FLK A;  2OAZ A;  2B3L A;  1R5H A;  4IF7 A;  2DFI A;  2GU6 A;  2V3Z A;  4FLL A;  1W7V A;  1QXZ A;  5FCH A;  3PKC A;  2BWW A;  4JUQ A;  5CE6 A;  2B3H A;  2EA4 A;  3CTZ A;  2GU5 A;  1WBQ A;  2Q92 A;  5CIK A;  1YW9 A;  4S00 A;  2GTX A;  2P99 A;  2GG5 A;  1XGM A;  2EVM A;  3FM3 A;  2GG7 A;  4MAT A;  2P9A A;  4U75 A;  4A6W A;  2GG0 A;  2V3Y A;  4OOK A;  1XGN A;  1WL9 A;  2ADU A;  4ZNG A;  2BHC A;  3IU8 A;  2OKN A;  1BN5 A;  4FUK A;  5CLS A;  4RZZ A;  1O0X A;  1YW8 A;  2GG3 A;  2GZ5 A;  2Q95 A;  4IDY A;  4U6C A;  5JHU A;  1WLR A;  1QZY A;  5D6E A;  2GU7 A;  2GU4 A;  1WL6 A;  3BIQ A;  1Y1N A;  2V3X A;  2GG9 A;  1BOA A;  1YW7 A;  2EVO A;  2Q8K A;  1MAT A;  3FMR A;  4U6W A;  4FLI A;  1C24 A;  4IEC A;  4IU6 A;  4S2R P;  4U6J A;  2BWX A;  1XGO A;  2Q93 A;  3L7G A;  1CHM A;  3MAT A;  4Z7M A;  5JFR A;  5CDL A;  3IG4 A;  1YVM A;  1PV9 A;  3D27 A;  3RVA A;  4FO8 A;  2NQ7 A;  1M35 A;  5CDV A;  4IKT A;  1JAW A;  4U6E A;  2BWS A;  2GGB A;  1C22 A;  2GGC A;  2NQ6 A;  2EVC A;  2BWV A;  2BWU A;  1KP0 A;  2G6P A;  2V6C A;  3CB6 A;  3PKD A;  1B59 A;  4PNC A;  3BIT A;  2BN7 A;  2EA2 A;  3PKB A;  4KM3 A;  4S2T P;  3ROR A;  2BB7 A;  1XGS A;  1WN1 A;  2MAT A;  4IKS A;  4S01 A;  3FMQ A;  3BIP A;  2Q96 A;  1QXW A;  3PKE A;  4U1B A;  4RGZ 1;  5FCF A;  4IKU A;  1KQ9 A;  1A16 A;  1YJ3 A;  2BWY A;  4RZY A;  2ZSG A;  3L24 A;  4U71 A;  4R60 A;  1WY2 A;  3S6B A;  3IU9 A;  4QR8 A; 
#chains in the Genus database with same CATH topology
 4ZWO A;  5CNX A;  5D6F A;  3TB5 A;  1R5G A;  1C27 A;  2BWT A;  1W2M A;  2BHB A;  3IU7 A;  1B6A A;  4U76 A;  4ZWU A;  2Q94 A;  1XNZ A;  4PV4 A;  2BHD A;  2P98 A;  2B3K A;  2BHA A;  1N51 A;  4FKC A;  2IW2 A;  4FLJ A;  4ZWP A;  5CDE A;  4IKR A;  1C21 A;  3Q6D A;  1R58 A;  4U69 A;  2BH3 A;  2GG8 A;  3PKA A;  1QXY A;  1C23 A;  2HOW A;  5E5B A;  1WKM A;  3TAV A;  2GA2 A;  4HXX A;  4IPA A;  4U73 A;  4B28 A;  2GG2 A;  5JI6 A;  3MR1 A;  4FO7 A;  3CB5 A;  4U6Z A;  4EGE A;  4A6V A;  1KQ0 A;  4U70 A;  3MX6 A;  4FLK A;  2OAZ A;  2B3L A;  1R5H A;  4IF7 A;  2DFI A;  2GU6 A;  2V3Z A;  4FLL A;  1W7V A;  1QXZ A;  5FCH A;  3PKC A;  2BWW A;  4JUQ A;  5CE6 A;  2B3H A;  2EA4 A;  3CTZ A;  2GU5 A;  1WBQ A;  2Q92 A;  5CIK A;  1YW9 A;  4S00 A;  2GTX A;  2P99 A;  2GG5 A;  1XGM A;  2EVM A;  3FM3 A;  2GG7 A;  4MAT A;  2P9A A;  4U75 A;  4A6W A;  2GG0 A;  2V3Y A;  4OOK A;  1XGN A;  1WL9 A;  2ADU A;  4ZNG A;  2BHC A;  3IU8 A;  2OKN A;  1BN5 A;  4FUK A;  5CLS A;  4RZZ A;  1O0X A;  1YW8 A;  2GG3 A;  2GZ5 A;  2Q95 A;  4IDY A;  4U6C A;  5JHU A;  1WLR A;  1QZY A;  5D6E A;  2GU7 A;  2GU4 A;  1WL6 A;  3BIQ A;  1Y1N A;  2V3X A;  2GG9 A;  1BOA A;  1YW7 A;  2EVO A;  2Q8K A;  1MAT A;  3FMR A;  4U6W A;  4FLI A;  1C24 A;  4IEC A;  4IU6 A;  4S2R P;  4U6J A;  2BWX A;  1XGO A;  2Q93 A;  3L7G A;  1CHM A;  3MAT A;  4Z7M A;  5JFR A;  5CDL A;  3IG4 A;  1YVM A;  1PV9 A;  3D27 A;  3RVA A;  4FO8 A;  2NQ7 A;  1M35 A;  5CDV A;  4IKT A;  1JAW A;  4U6E A;  2BWS A;  2GGB A;  1C22 A;  2GGC A;  2NQ6 A;  2EVC A;  2BWV A;  2BWU A;  1KP0 A;  2G6P A;  2V6C A;  3CB6 A;  3PKD A;  1B59 A;  4PNC A;  3BIT A;  2BN7 A;  2EA2 A;  3PKB A;  4KM3 A;  4S2T P;  3ROR A;  2BB7 A;  1XGS A;  1WN1 A;  2MAT A;  4IKS A;  4S01 A;  3FMQ A;  3BIP A;  2Q96 A;  1QXW A;  3PKE A;  4U1B A;  4RGZ 1;  5FCF A;  4IKU A;  1KQ9 A;  1A16 A;  1YJ3 A;  2BWY A;  4RZY A;  2ZSG A;  3L24 A;  4U71 A;  4R60 A;  1WY2 A;  3S6B A;  3IU9 A;  4QR8 A; 
#chains in the Genus database with same CATH homology
 4ZWO A;  5CNX A;  5D6F A;  3TB5 A;  1R5G A;  1C27 A;  2BWT A;  1W2M A;  2BHB A;  3IU7 A;  1B6A A;  4U76 A;  4ZWU A;  2Q94 A;  1XNZ A;  4PV4 A;  2BHD A;  2P98 A;  2B3K A;  2BHA A;  1N51 A;  4FKC A;  2IW2 A;  4FLJ A;  4ZWP A;  5CDE A;  4IKR A;  1C21 A;  3Q6D A;  1R58 A;  4U69 A;  2BH3 A;  2GG8 A;  3PKA A;  1QXY A;  1C23 A;  2HOW A;  5E5B A;  1WKM A;  3TAV A;  2GA2 A;  4HXX A;  4IPA A;  4U73 A;  4B28 A;  2GG2 A;  5JI6 A;  3MR1 A;  4FO7 A;  3CB5 A;  4U6Z A;  4EGE A;  4A6V A;  1KQ0 A;  4U70 A;  3MX6 A;  4FLK A;  2OAZ A;  2B3L A;  1R5H A;  4IF7 A;  2DFI A;  2GU6 A;  2V3Z A;  4FLL A;  1W7V A;  1QXZ A;  5FCH A;  3PKC A;  2BWW A;  4JUQ A;  5CE6 A;  2B3H A;  2EA4 A;  3CTZ A;  2GU5 A;  1WBQ A;  2Q92 A;  5CIK A;  1YW9 A;  4S00 A;  2GTX A;  2P99 A;  2GG5 A;  1XGM A;  2EVM A;  3FM3 A;  2GG7 A;  4MAT A;  2P9A A;  4U75 A;  4A6W A;  2GG0 A;  2V3Y A;  4OOK A;  1XGN A;  1WL9 A;  2ADU A;  4ZNG A;  2BHC A;  3IU8 A;  2OKN A;  1BN5 A;  4FUK A;  5CLS A;  4RZZ A;  1O0X A;  1YW8 A;  2GG3 A;  2GZ5 A;  2Q95 A;  4IDY A;  4U6C A;  5JHU A;  1WLR A;  1QZY A;  5D6E A;  2GU7 A;  2GU4 A;  1WL6 A;  3BIQ A;  1Y1N A;  2V3X A;  2GG9 A;  1BOA A;  1YW7 A;  2EVO A;  2Q8K A;  1MAT A;  3FMR A;  4U6W A;  4FLI A;  1C24 A;  4IEC A;  4IU6 A;  4S2R P;  4U6J A;  2BWX A;  1XGO A;  2Q93 A;  3L7G A;  1CHM A;  3MAT A;  4Z7M A;  5JFR A;  5CDL A;  3IG4 A;  1YVM A;  1PV9 A;  3D27 A;  3RVA A;  4FO8 A;  2NQ7 A;  1M35 A;  5CDV A;  4IKT A;  1JAW A;  4U6E A;  2BWS A;  2GGB A;  1C22 A;  2GGC A;  2NQ6 A;  2EVC A;  2BWV A;  2BWU A;  1KP0 A;  2G6P A;  2V6C A;  3CB6 A;  3PKD A;  1B59 A;  4PNC A;  3BIT A;  2BN7 A;  2EA2 A;  3PKB A;  4KM3 A;  4S2T P;  3ROR A;  2BB7 A;  1XGS A;  1WN1 A;  2MAT A;  4IKS A;  4S01 A;  3FMQ A;  3BIP A;  2Q96 A;  1QXW A;  3PKE A;  4U1B A;  4RGZ 1;  5FCF A;  4IKU A;  1KQ9 A;  1A16 A;  1YJ3 A;  2BWY A;  4RZY A;  2ZSG A;  3L24 A;  4U71 A;  4R60 A;  1WY2 A;  3S6B A;  3IU9 A;  4QR8 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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