4U6JA

Hsmetap in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
b'YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
source organism Homo sapiens
molecule tags Hydrolase
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6jA00
3D27A 4A6VA 3CTZA 2B3KA 3IU8A 4JUQA 4EGEA 3MR1A 5CE6A 1BOAA 3BIPA 1WL9A 1YJ3A 2V3ZA 1Y1NA 4KM3A 1QXYA 1A16A 2EVMA 1C21A 2BWUA 2NQ6A 3PKEA 3RVAA 1M35A 4ZWOA 4U70A 4U76A 1WBQA 2BHCA 4U6JA 1XGSA 4U6ZA 2Q93A 2GU4A 2Q94A 1QXWA 4U71A 2V3YA 3MATA 1XNZA 2GG5A 1PV9A 2MATA 4ZNGA 2G6PA 2GG7A 4FUKA 4IKSA 3MX6A 5CDEA 4B28A 2GGBA 4RZYA 1JAWA 1QXZA 5D6FA 1R58A 3FMRA 4IKUA 2ZSGA 5CDVA 2P9AA 4FLKA 4S2RP 2P99A 4IDYA 2V3XA 1MATA 4U6EA 4Z7MA 2BB7A 2BHAA 1O0XA 4FLIA 1KP0A 1WKMA 1QZYA 1YVMA 2BWVA 2P98A 4S2TP 5CNXA 4R60A 2NQ7A 2BHBA 4U75A 5CLSA 1C22A 1B6AA 2IW2A 3PKDA 1C24A 1C23A 1B59A 2HOWA 3RORA 1W2MA 2GZ5A 5E5BA 1KQ0A 3IU9A 2GA2A 2Q8KA 2BWXA 2GTXA 5D6EA 3CB6A 4U69A 3S6BA 1C27A 2OKNA 1KQ9A 5CIKA 3IG4A 2BH3A 3CB5A 2EVCA 1WL6A 2EA4A 4FLJA 1XGNA 4ZWPA 2BHDA 4PNCA 1R5HA 2GU6A 1XGOA 4U6CA 4HXXA 4S00A 1WLRA 4IPAA 1W7VA 5JFRA 3BITA 3FM3A 4RZZA 1R5GA 3BIQA 3IU7A 3L24A 2V6CA 4U1BA 4QR8A 2OAZA 1YW8A 4FO7A 1YW9A 4FLLA 3PKCA 5FCFA 4IF7A 2Q96A 4A6WA 1CHMA 3Q6DA 4IKTA 4S01A 2GG2A 1XGMA 2BWTA 1WN1A 3FMQA 4MATA 4OOKA 4RGZ1 2Q95A 4IECA 2BWSA 4U6WA 4ZWUA 5FCHA 2Q92A 2GG9A 1YW7A 2B3LA 5CDLA 2EVOA 4PV4A 1WY2A 1N51A 1BN5A 2BWWA 2GU5A 2BN7A 3PKBA 2EA2A 2GG0A 2GGCA 3TB5A 4IU6A 2GU7A 2ADUA 2B3HA 5JHUA 3PKAA 2GG3A 2GG8A 3L7GA 4FKCA 3TAVA 5JI6A 4IKRA 2BWYA 4U73A 4FO8A 2DFIA
chains in the Genus database with same CATH superfamily
3D27A 4A6VA 3CTZA 2B3KA 3IU8A 4JUQA 4EGEA 3MR1A 5CE6A 1BOAA 3BIPA 1WL9A 1YJ3A 2V3ZA 1Y1NA 4KM3A 1QXYA 1A16A 2EVMA 1C21A 2BWUA 2NQ6A 3PKEA 3RVAA 1M35A 4ZWOA 4U70A 4U76A 1WBQA 2BHCA 4U6JA 1XGSA 4U6ZA 2Q93A 2GU4A 2Q94A 1QXWA 4U71A 2V3YA 3MATA 1XNZA 2GG5A 1PV9A 2MATA 4ZNGA 2G6PA 2GG7A 4FUKA 4IKSA 3MX6A 5CDEA 4B28A 2GGBA 4RZYA 1JAWA 1QXZA 5D6FA 1R58A 3FMRA 4IKUA 2ZSGA 5CDVA 2P9AA 4FLKA 4S2RP 2P99A 4IDYA 2V3XA 1MATA 4U6EA 4Z7MA 2BB7A 2BHAA 1O0XA 4FLIA 1KP0A 1WKMA 1QZYA 1YVMA 2BWVA 2P98A 4S2TP 5CNXA 4R60A 2NQ7A 2BHBA 4U75A 5CLSA 1C22A 1B6AA 2IW2A 3PKDA 1C24A 1C23A 1B59A 2HOWA 3RORA 1W2MA 2GZ5A 5E5BA 1KQ0A 3IU9A 2GA2A 2Q8KA 2BWXA 2GTXA 5D6EA 3CB6A 4U69A 3S6BA 1C27A 2OKNA 1KQ9A 5CIKA 3IG4A 2BH3A 3CB5A 2EVCA 1WL6A 2EA4A 4FLJA 1XGNA 4ZWPA 2BHDA 4PNCA 1R5HA 2GU6A 1XGOA 4U6CA 4HXXA 4S00A 1WLRA 4IPAA 1W7VA 5JFRA 3BITA 3FM3A 4RZZA 1R5GA 3BIQA 3IU7A 3L24A 2V6CA 4U1BA 4QR8A 2OAZA 1YW8A 4FO7A 1YW9A 4FLLA 3PKCA 5FCFA 4IF7A 2Q96A 4A6WA 1CHMA 3Q6DA 4IKTA 4S01A 2GG2A 1XGMA 2BWTA 1WN1A 3FMQA 4MATA 4OOKA 4RGZ1 2Q95A 4IECA 2BWSA 4U6WA 4ZWUA 5FCHA 2Q92A 2GG9A 1YW7A 2B3LA 5CDLA 2EVOA 4PV4A 1WY2A 1N51A 1BN5A 2BWWA 2GU5A 2BN7A 3PKBA 2EA2A 2GG0A 2GGCA 3TB5A 4IU6A 2GU7A 2ADUA 2B3HA 5JHUA 3PKAA 2GG3A 2GG8A 3L7GA 4FKCA 3TAVA 5JI6A 4IKRA 2BWYA 4U73A 4FO8A 2DFIA
chains in the Genus database with same CATH topology
3D27A 4A6VA 3CTZA 2B3KA 3IU8A 4JUQA 4EGEA 3MR1A 5CE6A 1BOAA 3BIPA 1WL9A 1YJ3A 2V3ZA 1Y1NA 4KM3A 1QXYA 1A16A 2EVMA 1C21A 2BWUA 2NQ6A 3PKEA 3RVAA 1M35A 4ZWOA 4U70A 4U76A 1WBQA 2BHCA 4U6JA 1XGSA 4U6ZA 2Q93A 2GU4A 2Q94A 1QXWA 4U71A 2V3YA 3MATA 1XNZA 2GG5A 1PV9A 2MATA 4ZNGA 2G6PA 2GG7A 4FUKA 4IKSA 3MX6A 5CDEA 4B28A 2GGBA 4RZYA 1JAWA 1QXZA 5D6FA 1R58A 3FMRA 4IKUA 2ZSGA 5CDVA 2P9AA 4FLKA 4S2RP 2P99A 4IDYA 2V3XA 1MATA 4U6EA 4Z7MA 2BB7A 2BHAA 1O0XA 4FLIA 1KP0A 1WKMA 1QZYA 1YVMA 2BWVA 2P98A 4S2TP 5CNXA 4R60A 2NQ7A 2BHBA 4U75A 5CLSA 1C22A 1B6AA 2IW2A 3PKDA 1C24A 1C23A 1B59A 2HOWA 3RORA 1W2MA 2GZ5A 5E5BA 1KQ0A 3IU9A 2GA2A 2Q8KA 2BWXA 2GTXA 5D6EA 3CB6A 4U69A 3S6BA 1C27A 2OKNA 1KQ9A 5CIKA 3IG4A 2BH3A 3CB5A 2EVCA 1WL6A 2EA4A 4FLJA 1XGNA 4ZWPA 2BHDA 4PNCA 1R5HA 2GU6A 1XGOA 4U6CA 4HXXA 4S00A 1WLRA 4IPAA 1W7VA 5JFRA 3BITA 3FM3A 4RZZA 1R5GA 3BIQA 3IU7A 3L24A 2V6CA 4U1BA 4QR8A 2OAZA 1YW8A 4FO7A 1YW9A 4FLLA 3PKCA 5FCFA 4IF7A 2Q96A 4A6WA 1CHMA 3Q6DA 4IKTA 4S01A 2GG2A 1XGMA 2BWTA 1WN1A 3FMQA 4MATA 4OOKA 4RGZ1 2Q95A 4IECA 2BWSA 4U6WA 4ZWUA 5FCHA 2Q92A 2GG9A 1YW7A 2B3LA 5CDLA 2EVOA 4PV4A 1WY2A 1N51A 1BN5A 2BWWA 2GU5A 2BN7A 3PKBA 2EA2A 2GG0A 2GGCA 3TB5A 4IU6A 2GU7A 2ADUA 2B3HA 5JHUA 3PKAA 2GG3A 2GG8A 3L7GA 4FKCA 3TAVA 5JI6A 4IKRA 2BWYA 4U73A 4FO8A 2DFIA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3D27 A;  4A6V A;  3CTZ A;  2B3K A;  3IU8 A;  4JUQ A;  4EGE A;  3MR1 A;  5CE6 A;  1BOA A;  3BIP A;  1WL9 A;  1YJ3 A;  2V3Z A;  1Y1N A;  4KM3 A;  1QXY A;  1A16 A;  2EVM A;  1C21 A;  2BWU A;  2NQ6 A;  3PKE A;  3RVA A;  1M35 A;  4ZWO A;  4U70 A;  4U76 A;  1WBQ A;  2BHC A;  4U6J A;  1XGS A;  4U6Z A;  2Q93 A;  2GU4 A;  2Q94 A;  1QXW A;  4U71 A;  2V3Y A;  3MAT A;  1XNZ A;  2GG5 A;  1PV9 A;  2MAT A;  4ZNG A;  2G6P A;  2GG7 A;  4FUK A;  4IKS A;  3MX6 A;  5CDE A;  4B28 A;  2GGB A;  4RZY A;  1JAW A;  1QXZ A;  5D6F A;  1R58 A;  3FMR A;  4IKU A;  2ZSG A;  5CDV A;  2P9A A;  4FLK A;  4S2R P;  2P99 A;  4IDY A;  2V3X A;  1MAT A;  4U6E A;  4Z7M A;  2BB7 A;  2BHA A;  1O0X A;  4FLI A;  1KP0 A;  1WKM A;  1QZY A;  1YVM A;  2BWV A;  2P98 A;  4S2T P;  5CNX A;  4R60 A;  2NQ7 A;  2BHB A;  4U75 A;  5CLS A;  1C22 A;  1B6A A;  2IW2 A;  3PKD A;  1C24 A;  1C23 A;  1B59 A;  2HOW A;  3ROR A;  1W2M A;  2GZ5 A;  5E5B A;  1KQ0 A;  3IU9 A;  2GA2 A;  2Q8K A;  2BWX A;  2GTX A;  5D6E A;  3CB6 A;  4U69 A;  3S6B A;  1C27 A;  2OKN A;  1KQ9 A;  5CIK A;  3IG4 A;  2BH3 A;  3CB5 A;  2EVC A;  1WL6 A;  2EA4 A;  4FLJ A;  1XGN A;  4ZWP A;  2BHD A;  4PNC A;  1R5H A;  2GU6 A;  1XGO A;  4U6C A;  4HXX A;  4S00 A;  1WLR A;  4IPA A;  1W7V A;  5JFR A;  3BIT A;  3FM3 A;  4RZZ A;  1R5G A;  3BIQ A;  3IU7 A;  3L24 A;  2V6C A;  4U1B A;  4QR8 A;  2OAZ A;  1YW8 A;  4FO7 A;  1YW9 A;  4FLL A;  3PKC A;  5FCF A;  4IF7 A;  2Q96 A;  4A6W A;  1CHM A;  3Q6D A;  4IKT A;  4S01 A;  2GG2 A;  1XGM A;  2BWT A;  1WN1 A;  3FMQ A;  4MAT A;  4OOK A;  4RGZ 1;  2Q95 A;  4IEC A;  2BWS A;  4U6W A;  4ZWU A;  5FCH A;  2Q92 A;  2GG9 A;  1YW7 A;  2B3L A;  5CDL A;  2EVO A;  4PV4 A;  1WY2 A;  1N51 A;  1BN5 A;  2BWW A;  2GU5 A;  2BN7 A;  3PKB A;  2EA2 A;  2GG0 A;  2GGC A;  3TB5 A;  4IU6 A;  2GU7 A;  2ADU A;  2B3H A;  5JHU A;  3PKA A;  2GG3 A;  2GG8 A;  3L7G A;  4FKC A;  3TAV A;  5JI6 A;  4IKR A;  2BWY A;  4U73 A;  4FO8 A;  2DFI A; 
#chains in the Genus database with same CATH topology
 3D27 A;  4A6V A;  3CTZ A;  2B3K A;  3IU8 A;  4JUQ A;  4EGE A;  3MR1 A;  5CE6 A;  1BOA A;  3BIP A;  1WL9 A;  1YJ3 A;  2V3Z A;  1Y1N A;  4KM3 A;  1QXY A;  1A16 A;  2EVM A;  1C21 A;  2BWU A;  2NQ6 A;  3PKE A;  3RVA A;  1M35 A;  4ZWO A;  4U70 A;  4U76 A;  1WBQ A;  2BHC A;  4U6J A;  1XGS A;  4U6Z A;  2Q93 A;  2GU4 A;  2Q94 A;  1QXW A;  4U71 A;  2V3Y A;  3MAT A;  1XNZ A;  2GG5 A;  1PV9 A;  2MAT A;  4ZNG A;  2G6P A;  2GG7 A;  4FUK A;  4IKS A;  3MX6 A;  5CDE A;  4B28 A;  2GGB A;  4RZY A;  1JAW A;  1QXZ A;  5D6F A;  1R58 A;  3FMR A;  4IKU A;  2ZSG A;  5CDV A;  2P9A A;  4FLK A;  4S2R P;  2P99 A;  4IDY A;  2V3X A;  1MAT A;  4U6E A;  4Z7M A;  2BB7 A;  2BHA A;  1O0X A;  4FLI A;  1KP0 A;  1WKM A;  1QZY A;  1YVM A;  2BWV A;  2P98 A;  4S2T P;  5CNX A;  4R60 A;  2NQ7 A;  2BHB A;  4U75 A;  5CLS A;  1C22 A;  1B6A A;  2IW2 A;  3PKD A;  1C24 A;  1C23 A;  1B59 A;  2HOW A;  3ROR A;  1W2M A;  2GZ5 A;  5E5B A;  1KQ0 A;  3IU9 A;  2GA2 A;  2Q8K A;  2BWX A;  2GTX A;  5D6E A;  3CB6 A;  4U69 A;  3S6B A;  1C27 A;  2OKN A;  1KQ9 A;  5CIK A;  3IG4 A;  2BH3 A;  3CB5 A;  2EVC A;  1WL6 A;  2EA4 A;  4FLJ A;  1XGN A;  4ZWP A;  2BHD A;  4PNC A;  1R5H A;  2GU6 A;  1XGO A;  4U6C A;  4HXX A;  4S00 A;  1WLR A;  4IPA A;  1W7V A;  5JFR A;  3BIT A;  3FM3 A;  4RZZ A;  1R5G A;  3BIQ A;  3IU7 A;  3L24 A;  2V6C A;  4U1B A;  4QR8 A;  2OAZ A;  1YW8 A;  4FO7 A;  1YW9 A;  4FLL A;  3PKC A;  5FCF A;  4IF7 A;  2Q96 A;  4A6W A;  1CHM A;  3Q6D A;  4IKT A;  4S01 A;  2GG2 A;  1XGM A;  2BWT A;  1WN1 A;  3FMQ A;  4MAT A;  4OOK A;  4RGZ 1;  2Q95 A;  4IEC A;  2BWS A;  4U6W A;  4ZWU A;  5FCH A;  2Q92 A;  2GG9 A;  1YW7 A;  2B3L A;  5CDL A;  2EVO A;  4PV4 A;  1WY2 A;  1N51 A;  1BN5 A;  2BWW A;  2GU5 A;  2BN7 A;  3PKB A;  2EA2 A;  2GG0 A;  2GGC A;  3TB5 A;  4IU6 A;  2GU7 A;  2ADU A;  2B3H A;  5JHU A;  3PKA A;  2GG3 A;  2GG8 A;  3L7G A;  4FKC A;  3TAV A;  5JI6 A;  4IKR A;  2BWY A;  4U73 A;  4FO8 A;  2DFI A; 
#chains in the Genus database with same CATH homology
 3D27 A;  4A6V A;  3CTZ A;  2B3K A;  3IU8 A;  4JUQ A;  4EGE A;  3MR1 A;  5CE6 A;  1BOA A;  3BIP A;  1WL9 A;  1YJ3 A;  2V3Z A;  1Y1N A;  4KM3 A;  1QXY A;  1A16 A;  2EVM A;  1C21 A;  2BWU A;  2NQ6 A;  3PKE A;  3RVA A;  1M35 A;  4ZWO A;  4U70 A;  4U76 A;  1WBQ A;  2BHC A;  4U6J A;  1XGS A;  4U6Z A;  2Q93 A;  2GU4 A;  2Q94 A;  1QXW A;  4U71 A;  2V3Y A;  3MAT A;  1XNZ A;  2GG5 A;  1PV9 A;  2MAT A;  4ZNG A;  2G6P A;  2GG7 A;  4FUK A;  4IKS A;  3MX6 A;  5CDE A;  4B28 A;  2GGB A;  4RZY A;  1JAW A;  1QXZ A;  5D6F A;  1R58 A;  3FMR A;  4IKU A;  2ZSG A;  5CDV A;  2P9A A;  4FLK A;  4S2R P;  2P99 A;  4IDY A;  2V3X A;  1MAT A;  4U6E A;  4Z7M A;  2BB7 A;  2BHA A;  1O0X A;  4FLI A;  1KP0 A;  1WKM A;  1QZY A;  1YVM A;  2BWV A;  2P98 A;  4S2T P;  5CNX A;  4R60 A;  2NQ7 A;  2BHB A;  4U75 A;  5CLS A;  1C22 A;  1B6A A;  2IW2 A;  3PKD A;  1C24 A;  1C23 A;  1B59 A;  2HOW A;  3ROR A;  1W2M A;  2GZ5 A;  5E5B A;  1KQ0 A;  3IU9 A;  2GA2 A;  2Q8K A;  2BWX A;  2GTX A;  5D6E A;  3CB6 A;  4U69 A;  3S6B A;  1C27 A;  2OKN A;  1KQ9 A;  5CIK A;  3IG4 A;  2BH3 A;  3CB5 A;  2EVC A;  1WL6 A;  2EA4 A;  4FLJ A;  1XGN A;  4ZWP A;  2BHD A;  4PNC A;  1R5H A;  2GU6 A;  1XGO A;  4U6C A;  4HXX A;  4S00 A;  1WLR A;  4IPA A;  1W7V A;  5JFR A;  3BIT A;  3FM3 A;  4RZZ A;  1R5G A;  3BIQ A;  3IU7 A;  3L24 A;  2V6C A;  4U1B A;  4QR8 A;  2OAZ A;  1YW8 A;  4FO7 A;  1YW9 A;  4FLL A;  3PKC A;  5FCF A;  4IF7 A;  2Q96 A;  4A6W A;  1CHM A;  3Q6D A;  4IKT A;  4S01 A;  2GG2 A;  1XGM A;  2BWT A;  1WN1 A;  3FMQ A;  4MAT A;  4OOK A;  4RGZ 1;  2Q95 A;  4IEC A;  2BWS A;  4U6W A;  4ZWU A;  5FCH A;  2Q92 A;  2GG9 A;  1YW7 A;  2B3L A;  5CDL A;  2EVO A;  4PV4 A;  1WY2 A;  1N51 A;  1BN5 A;  2BWW A;  2GU5 A;  2BN7 A;  3PKB A;  2EA2 A;  2GG0 A;  2GGC A;  3TB5 A;  4IU6 A;  2GU7 A;  2ADU A;  2B3H A;  5JHU A;  3PKA A;  2GG3 A;  2GG8 A;  3L7G A;  4FKC A;  3TAV A;  5JI6 A;  4IKR A;  2BWY A;  4U73 A;  4FO8 A;  2DFI A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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