4U6JA

Hsmetap in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6jA00
4PV4A 4RZYA 4U6ZA 2GA2A 5CLSA 1YVMA 2BWVA 3IG4A 4RZZA 2MATA 5FCHA 3FM3A 4A6VA 4RGZ1 2B3KA 4U75A 1M35A 4IKUA 1XGNA 5JHUA 2Q92A 1C22A 2V3ZA 4U70A 4ZNGA 1R5HA 3FMQA 5CE6A 1C24A 2GTXA 4QR8A 3BIQA 2BHDA 2GG0A 2Q95A 1KQ9A 2Q96A 3L24A 3PKDA 5FCFA 2GZ5A 4ZWUA 2GG3A 2GU5A 1XGSA 2V6CA 1N51A 2Q8KA 3L7GA 1BOAA 4HXXA 5D6FA 1WL9A 1B59A 1YW7A 2P98A 4U69A 1W2MA 3D27A 1CHMA 3IU7A 3PKCA 3TAVA 2EA4A 1MATA 3IU9A 2EVCA 2BHAA 3PKBA 4FKCA 4ZWOA 4IDYA 1YW9A 4IECA 1KP0A 2P99A 4FUKA 1B6AA 4U1BA 1WBQA 4Z7MA 4PNCA 3RORA 2GU6A 4S2TP 2BWYA 2Q93A 2EVMA 1C21A 4U76A 4U71A 1R58A 2GG2A 5E5BA 4IKRA 4OOKA 1QXWA 3IU8A 1JAWA 1QXYA 3MATA 2BWWA 2OAZA 4FO8A 1KQ0A 1XGMA 3CTZA 4U73A 1YW8A 2BN7A 2GU4A 4IKSA 1QXZA 2GGBA 1W7VA 4FLKA 3S6BA 1QZYA 2BWSA 4S00A 2DFIA 3BITA 5CDEA 4FO7A 4S01A 1A16A 4IF7A 5CDLA 4U6EA 3MR1A 2BHBA 3CB5A 5CDVA 1C27A 1O0XA 1WL6A 4S2RP 4A6WA 1WN1A 4FLIA 4KM3A 2NQ7A 2GGCA 4U6CA 2NQ6A 1BN5A 4U6JA 4EGEA 2V3XA 1XGOA 2B3HA 2ZSGA 3CB6A 5JI6A 1XNZA 5CNXA 2BB7A 2EVOA 5D6EA 1WLRA 2IW2A 4MATA 2GG8A 1WY2A 2GU7A 2HOWA 2EA2A 2OKNA 1C23A 1PV9A 4FLLA 2BH3A 2BWUA 1R5GA 2GG9A 1YJ3A 2Q94A 3FMRA 4B28A 5CIKA 5JFRA 3BIPA 3Q6DA 2P9AA 2BWXA 2GG7A 4R60A 4FLJA 2BHCA 2BWTA 3MX6A 3PKAA 4IU6A 2B3LA 3TB5A 4IPAA 2V3YA 1WKMA 1Y1NA 4IKTA 2G6PA 4ZWPA 4U6WA 4JUQA 3RVAA 2GG5A 2ADUA 3PKEA
chains in the Genus database with same CATH superfamily
4PV4A 4RZYA 4U6ZA 2GA2A 5CLSA 1YVMA 2BWVA 3IG4A 4RZZA 2MATA 5FCHA 3FM3A 4A6VA 4RGZ1 2B3KA 4U75A 1M35A 4IKUA 1XGNA 5JHUA 2Q92A 1C22A 2V3ZA 4U70A 4ZNGA 1R5HA 3FMQA 5CE6A 1C24A 2GTXA 4QR8A 3BIQA 2BHDA 2GG0A 2Q95A 1KQ9A 2Q96A 3L24A 3PKDA 5FCFA 2GZ5A 4ZWUA 2GG3A 2GU5A 1XGSA 2V6CA 1N51A 2Q8KA 3L7GA 1BOAA 4HXXA 5D6FA 1WL9A 1B59A 1YW7A 2P98A 4U69A 1W2MA 3D27A 1CHMA 3IU7A 3PKCA 3TAVA 2EA4A 1MATA 3IU9A 2EVCA 2BHAA 3PKBA 4FKCA 4ZWOA 4IDYA 1YW9A 4IECA 1KP0A 2P99A 4FUKA 1B6AA 4U1BA 1WBQA 4Z7MA 4PNCA 3RORA 2GU6A 4S2TP 2BWYA 2Q93A 2EVMA 1C21A 4U76A 4U71A 1R58A 2GG2A 5E5BA 4IKRA 4OOKA 1QXWA 3IU8A 1JAWA 1QXYA 3MATA 2BWWA 2OAZA 4FO8A 1KQ0A 1XGMA 3CTZA 4U73A 1YW8A 2BN7A 2GU4A 4IKSA 1QXZA 2GGBA 1W7VA 4FLKA 3S6BA 1QZYA 2BWSA 4S00A 2DFIA 3BITA 5CDEA 4FO7A 4S01A 1A16A 4IF7A 5CDLA 4U6EA 3MR1A 2BHBA 3CB5A 5CDVA 1C27A 1O0XA 1WL6A 4S2RP 4A6WA 1WN1A 4FLIA 4KM3A 2NQ7A 2GGCA 4U6CA 2NQ6A 1BN5A 4U6JA 4EGEA 2V3XA 1XGOA 2B3HA 2ZSGA 3CB6A 5JI6A 1XNZA 5CNXA 2BB7A 2EVOA 5D6EA 1WLRA 2IW2A 4MATA 2GG8A 1WY2A 2GU7A 2HOWA 2EA2A 2OKNA 1C23A 1PV9A 4FLLA 2BH3A 2BWUA 1R5GA 2GG9A 1YJ3A 2Q94A 3FMRA 4B28A 5CIKA 5JFRA 3BIPA 3Q6DA 2P9AA 2BWXA 2GG7A 4R60A 4FLJA 2BHCA 2BWTA 3MX6A 3PKAA 4IU6A 2B3LA 3TB5A 4IPAA 2V3YA 1WKMA 1Y1NA 4IKTA 2G6PA 4ZWPA 4U6WA 4JUQA 3RVAA 2GG5A 2ADUA 3PKEA
chains in the Genus database with same CATH topology
4PV4A 4RZYA 4U6ZA 2GA2A 5CLSA 1YVMA 2BWVA 3IG4A 4RZZA 2MATA 5FCHA 3FM3A 4A6VA 4RGZ1 2B3KA 4U75A 1M35A 4IKUA 1XGNA 5JHUA 2Q92A 1C22A 2V3ZA 4U70A 4ZNGA 1R5HA 3FMQA 5CE6A 1C24A 2GTXA 4QR8A 3BIQA 2BHDA 2GG0A 2Q95A 1KQ9A 2Q96A 3L24A 3PKDA 5FCFA 2GZ5A 4ZWUA 2GG3A 2GU5A 1XGSA 2V6CA 1N51A 2Q8KA 3L7GA 1BOAA 4HXXA 5D6FA 1WL9A 1B59A 1YW7A 2P98A 4U69A 1W2MA 3D27A 1CHMA 3IU7A 3PKCA 3TAVA 2EA4A 1MATA 3IU9A 2EVCA 2BHAA 3PKBA 4FKCA 4ZWOA 4IDYA 1YW9A 4IECA 1KP0A 2P99A 4FUKA 1B6AA 4U1BA 1WBQA 4Z7MA 4PNCA 3RORA 2GU6A 4S2TP 2BWYA 2Q93A 2EVMA 1C21A 4U76A 4U71A 1R58A 2GG2A 5E5BA 4IKRA 4OOKA 1QXWA 3IU8A 1JAWA 1QXYA 3MATA 2BWWA 2OAZA 4FO8A 1KQ0A 1XGMA 3CTZA 4U73A 1YW8A 2BN7A 2GU4A 4IKSA 1QXZA 2GGBA 1W7VA 4FLKA 3S6BA 1QZYA 2BWSA 4S00A 2DFIA 3BITA 5CDEA 4FO7A 4S01A 1A16A 4IF7A 5CDLA 4U6EA 3MR1A 2BHBA 3CB5A 5CDVA 1C27A 1O0XA 1WL6A 4S2RP 4A6WA 1WN1A 4FLIA 4KM3A 2NQ7A 2GGCA 4U6CA 2NQ6A 1BN5A 4U6JA 4EGEA 2V3XA 1XGOA 2B3HA 2ZSGA 3CB6A 5JI6A 1XNZA 5CNXA 2BB7A 2EVOA 5D6EA 1WLRA 2IW2A 4MATA 2GG8A 1WY2A 2GU7A 2HOWA 2EA2A 2OKNA 1C23A 1PV9A 4FLLA 2BH3A 2BWUA 1R5GA 2GG9A 1YJ3A 2Q94A 3FMRA 4B28A 5CIKA 5JFRA 3BIPA 3Q6DA 2P9AA 2BWXA 2GG7A 4R60A 4FLJA 2BHCA 2BWTA 3MX6A 3PKAA 4IU6A 2B3LA 3TB5A 4IPAA 2V3YA 1WKMA 1Y1NA 4IKTA 2G6PA 4ZWPA 4U6WA 4JUQA 3RVAA 2GG5A 2ADUA 3PKEA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4PV4 A;  4RZY A;  4U6Z A;  2GA2 A;  5CLS A;  1YVM A;  2BWV A;  3IG4 A;  4RZZ A;  2MAT A;  5FCH A;  3FM3 A;  4A6V A;  4RGZ 1;  2B3K A;  4U75 A;  1M35 A;  4IKU A;  1XGN A;  5JHU A;  2Q92 A;  1C22 A;  2V3Z A;  4U70 A;  4ZNG A;  1R5H A;  3FMQ A;  5CE6 A;  1C24 A;  2GTX A;  4QR8 A;  3BIQ A;  2BHD A;  2GG0 A;  2Q95 A;  1KQ9 A;  2Q96 A;  3L24 A;  3PKD A;  5FCF A;  2GZ5 A;  4ZWU A;  2GG3 A;  2GU5 A;  1XGS A;  2V6C A;  1N51 A;  2Q8K A;  3L7G A;  1BOA A;  4HXX A;  5D6F A;  1WL9 A;  1B59 A;  1YW7 A;  2P98 A;  4U69 A;  1W2M A;  3D27 A;  1CHM A;  3IU7 A;  3PKC A;  3TAV A;  2EA4 A;  1MAT A;  3IU9 A;  2EVC A;  2BHA A;  3PKB A;  4FKC A;  4ZWO A;  4IDY A;  1YW9 A;  4IEC A;  1KP0 A;  2P99 A;  4FUK A;  1B6A A;  4U1B A;  1WBQ A;  4Z7M A;  4PNC A;  3ROR A;  2GU6 A;  4S2T P;  2BWY A;  2Q93 A;  2EVM A;  1C21 A;  4U76 A;  4U71 A;  1R58 A;  2GG2 A;  5E5B A;  4IKR A;  4OOK A;  1QXW A;  3IU8 A;  1JAW A;  1QXY A;  3MAT A;  2BWW A;  2OAZ A;  4FO8 A;  1KQ0 A;  1XGM A;  3CTZ A;  4U73 A;  1YW8 A;  2BN7 A;  2GU4 A;  4IKS A;  1QXZ A;  2GGB A;  1W7V A;  4FLK A;  3S6B A;  1QZY A;  2BWS A;  4S00 A;  2DFI A;  3BIT A;  5CDE A;  4FO7 A;  4S01 A;  1A16 A;  4IF7 A;  5CDL A;  4U6E A;  3MR1 A;  2BHB A;  3CB5 A;  5CDV A;  1C27 A;  1O0X A;  1WL6 A;  4S2R P;  4A6W A;  1WN1 A;  4FLI A;  4KM3 A;  2NQ7 A;  2GGC A;  4U6C A;  2NQ6 A;  1BN5 A;  4U6J A;  4EGE A;  2V3X A;  1XGO A;  2B3H A;  2ZSG A;  3CB6 A;  5JI6 A;  1XNZ A;  5CNX A;  2BB7 A;  2EVO A;  5D6E A;  1WLR A;  2IW2 A;  4MAT A;  2GG8 A;  1WY2 A;  2GU7 A;  2HOW A;  2EA2 A;  2OKN A;  1C23 A;  1PV9 A;  4FLL A;  2BH3 A;  2BWU A;  1R5G A;  2GG9 A;  1YJ3 A;  2Q94 A;  3FMR A;  4B28 A;  5CIK A;  5JFR A;  3BIP A;  3Q6D A;  2P9A A;  2BWX A;  2GG7 A;  4R60 A;  4FLJ A;  2BHC A;  2BWT A;  3MX6 A;  3PKA A;  4IU6 A;  2B3L A;  3TB5 A;  4IPA A;  2V3Y A;  1WKM A;  1Y1N A;  4IKT A;  2G6P A;  4ZWP A;  4U6W A;  4JUQ A;  3RVA A;  2GG5 A;  2ADU A;  3PKE A; 
#chains in the Genus database with same CATH topology
 4PV4 A;  4RZY A;  4U6Z A;  2GA2 A;  5CLS A;  1YVM A;  2BWV A;  3IG4 A;  4RZZ A;  2MAT A;  5FCH A;  3FM3 A;  4A6V A;  4RGZ 1;  2B3K A;  4U75 A;  1M35 A;  4IKU A;  1XGN A;  5JHU A;  2Q92 A;  1C22 A;  2V3Z A;  4U70 A;  4ZNG A;  1R5H A;  3FMQ A;  5CE6 A;  1C24 A;  2GTX A;  4QR8 A;  3BIQ A;  2BHD A;  2GG0 A;  2Q95 A;  1KQ9 A;  2Q96 A;  3L24 A;  3PKD A;  5FCF A;  2GZ5 A;  4ZWU A;  2GG3 A;  2GU5 A;  1XGS A;  2V6C A;  1N51 A;  2Q8K A;  3L7G A;  1BOA A;  4HXX A;  5D6F A;  1WL9 A;  1B59 A;  1YW7 A;  2P98 A;  4U69 A;  1W2M A;  3D27 A;  1CHM A;  3IU7 A;  3PKC A;  3TAV A;  2EA4 A;  1MAT A;  3IU9 A;  2EVC A;  2BHA A;  3PKB A;  4FKC A;  4ZWO A;  4IDY A;  1YW9 A;  4IEC A;  1KP0 A;  2P99 A;  4FUK A;  1B6A A;  4U1B A;  1WBQ A;  4Z7M A;  4PNC A;  3ROR A;  2GU6 A;  4S2T P;  2BWY A;  2Q93 A;  2EVM A;  1C21 A;  4U76 A;  4U71 A;  1R58 A;  2GG2 A;  5E5B A;  4IKR A;  4OOK A;  1QXW A;  3IU8 A;  1JAW A;  1QXY A;  3MAT A;  2BWW A;  2OAZ A;  4FO8 A;  1KQ0 A;  1XGM A;  3CTZ A;  4U73 A;  1YW8 A;  2BN7 A;  2GU4 A;  4IKS A;  1QXZ A;  2GGB A;  1W7V A;  4FLK A;  3S6B A;  1QZY A;  2BWS A;  4S00 A;  2DFI A;  3BIT A;  5CDE A;  4FO7 A;  4S01 A;  1A16 A;  4IF7 A;  5CDL A;  4U6E A;  3MR1 A;  2BHB A;  3CB5 A;  5CDV A;  1C27 A;  1O0X A;  1WL6 A;  4S2R P;  4A6W A;  1WN1 A;  4FLI A;  4KM3 A;  2NQ7 A;  2GGC A;  4U6C A;  2NQ6 A;  1BN5 A;  4U6J A;  4EGE A;  2V3X A;  1XGO A;  2B3H A;  2ZSG A;  3CB6 A;  5JI6 A;  1XNZ A;  5CNX A;  2BB7 A;  2EVO A;  5D6E A;  1WLR A;  2IW2 A;  4MAT A;  2GG8 A;  1WY2 A;  2GU7 A;  2HOW A;  2EA2 A;  2OKN A;  1C23 A;  1PV9 A;  4FLL A;  2BH3 A;  2BWU A;  1R5G A;  2GG9 A;  1YJ3 A;  2Q94 A;  3FMR A;  4B28 A;  5CIK A;  5JFR A;  3BIP A;  3Q6D A;  2P9A A;  2BWX A;  2GG7 A;  4R60 A;  4FLJ A;  2BHC A;  2BWT A;  3MX6 A;  3PKA A;  4IU6 A;  2B3L A;  3TB5 A;  4IPA A;  2V3Y A;  1WKM A;  1Y1N A;  4IKT A;  2G6P A;  4ZWP A;  4U6W A;  4JUQ A;  3RVA A;  2GG5 A;  2ADU A;  3PKE A; 
#chains in the Genus database with same CATH homology
 4PV4 A;  4RZY A;  4U6Z A;  2GA2 A;  5CLS A;  1YVM A;  2BWV A;  3IG4 A;  4RZZ A;  2MAT A;  5FCH A;  3FM3 A;  4A6V A;  4RGZ 1;  2B3K A;  4U75 A;  1M35 A;  4IKU A;  1XGN A;  5JHU A;  2Q92 A;  1C22 A;  2V3Z A;  4U70 A;  4ZNG A;  1R5H A;  3FMQ A;  5CE6 A;  1C24 A;  2GTX A;  4QR8 A;  3BIQ A;  2BHD A;  2GG0 A;  2Q95 A;  1KQ9 A;  2Q96 A;  3L24 A;  3PKD A;  5FCF A;  2GZ5 A;  4ZWU A;  2GG3 A;  2GU5 A;  1XGS A;  2V6C A;  1N51 A;  2Q8K A;  3L7G A;  1BOA A;  4HXX A;  5D6F A;  1WL9 A;  1B59 A;  1YW7 A;  2P98 A;  4U69 A;  1W2M A;  3D27 A;  1CHM A;  3IU7 A;  3PKC A;  3TAV A;  2EA4 A;  1MAT A;  3IU9 A;  2EVC A;  2BHA A;  3PKB A;  4FKC A;  4ZWO A;  4IDY A;  1YW9 A;  4IEC A;  1KP0 A;  2P99 A;  4FUK A;  1B6A A;  4U1B A;  1WBQ A;  4Z7M A;  4PNC A;  3ROR A;  2GU6 A;  4S2T P;  2BWY A;  2Q93 A;  2EVM A;  1C21 A;  4U76 A;  4U71 A;  1R58 A;  2GG2 A;  5E5B A;  4IKR A;  4OOK A;  1QXW A;  3IU8 A;  1JAW A;  1QXY A;  3MAT A;  2BWW A;  2OAZ A;  4FO8 A;  1KQ0 A;  1XGM A;  3CTZ A;  4U73 A;  1YW8 A;  2BN7 A;  2GU4 A;  4IKS A;  1QXZ A;  2GGB A;  1W7V A;  4FLK A;  3S6B A;  1QZY A;  2BWS A;  4S00 A;  2DFI A;  3BIT A;  5CDE A;  4FO7 A;  4S01 A;  1A16 A;  4IF7 A;  5CDL A;  4U6E A;  3MR1 A;  2BHB A;  3CB5 A;  5CDV A;  1C27 A;  1O0X A;  1WL6 A;  4S2R P;  4A6W A;  1WN1 A;  4FLI A;  4KM3 A;  2NQ7 A;  2GGC A;  4U6C A;  2NQ6 A;  1BN5 A;  4U6J A;  4EGE A;  2V3X A;  1XGO A;  2B3H A;  2ZSG A;  3CB6 A;  5JI6 A;  1XNZ A;  5CNX A;  2BB7 A;  2EVO A;  5D6E A;  1WLR A;  2IW2 A;  4MAT A;  2GG8 A;  1WY2 A;  2GU7 A;  2HOW A;  2EA2 A;  2OKN A;  1C23 A;  1PV9 A;  4FLL A;  2BH3 A;  2BWU A;  1R5G A;  2GG9 A;  1YJ3 A;  2Q94 A;  3FMR A;  4B28 A;  5CIK A;  5JFR A;  3BIP A;  3Q6D A;  2P9A A;  2BWX A;  2GG7 A;  4R60 A;  4FLJ A;  2BHC A;  2BWT A;  3MX6 A;  3PKA A;  4IU6 A;  2B3L A;  3TB5 A;  4IPA A;  2V3Y A;  1WKM A;  1Y1N A;  4IKT A;  2G6P A;  4ZWP A;  4U6W A;  4JUQ A;  3RVA A;  2GG5 A;  2ADU A;  3PKE A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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