2P9AA

E. coli methionine aminopeptidase dimetalated with inhibitor ye6
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli
publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 83
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p9aA00
4FLJA 5D6EA 3BIQA 4U6ZA 4KM3A 2EVMA 2GGCA 2BH3A 2MATA 2BWUA 2Q8KA 2OKNA 2V3ZA 2BWYA 3BIPA 1WY2A 1C22A 2V3XA 4FO7A 4FKCA 5FCFA 3MATA 1BN5A 2OAZA 3RORA 2BHAA 2GTXA 4IKUA 5CE6A 1QXYA 2P9AA 3FMQA 3IU8A 3L24A 4IF7A 2GG3A 2V6CA 3MX6A 5JI6A 5CDEA 1XGNA 2EA4A 1WLRA 5CDVA 2Q96A 5E5BA 4PNCA 1YW9A 4ZWPA 3PKEA 3Q6DA 1C21A 4MATA 1JAWA 1CHMA 4Z7MA 1A16A 4U6EA 3FM3A 4U76A 2NQ6A 2BWVA 3IU7A 1W2MA 1WKMA 2GU4A 1M35A 1O0XA 3TAVA 4IECA 4ZWUA 1YW8A 1KP0A 1N51A 4IU6A 4U6JA 3S6BA 1XGOA 5CDLA 1XGSA 2GGBA 2HOWA 4ZWOA 4U73A 3RVAA 2Q95A 1C27A 1QXZA 4IPAA 2DFIA 4U69A 2G6PA 2Q94A 3D27A 2GG9A 1R58A 1XNZA 4FLIA 1MATA 4B28A 1C24A 3BITA 1C23A 4S2RP 5CIKA 3IG4A 3L7GA 4OOKA 2GU7A 5JHUA 1R5HA 5JFRA 4S2TP 2GG2A 4U75A 2B3HA 4EGEA 2P98A 2Q93A 2GG0A 2GU6A 2EVCA 4ZNGA 4A6VA 1W7VA 2BWWA 4FUKA 1PV9A 5CNXA 3IU9A 1BOAA 2B3KA 4R60A 4U70A 5CLSA 1KQ9A 3CTZA 2GZ5A 3PKCA 2EVOA 1WL9A 1YVMA 2NQ7A 1R5GA 3MR1A 4A6WA 1XGMA 2EA2A 3CB5A 2BN7A 3PKBA 4JUQA 2GG8A 4PV4A 4S01A 4RGZ1 5FCHA 2V3YA 2BHDA 2GA2A 3FMRA 4IDYA 2GG7A 4U6CA 2GG5A 4RZZA 2Q92A 4U1BA 1QZYA 1YW7A 3TB5A 1WBQA 4IKRA 4IKSA 1B6AA 4FO8A 1QXWA 1Y1NA 2B3LA 3CB6A 2P99A 1YJ3A 4RZYA 1B59A 2BWSA 4U6WA 2GU5A 4U71A 2BWXA 2BHCA 2ADUA 1WL6A 4S00A 2ZSGA 4IKTA 4FLLA 1WN1A 2IW2A 5D6FA 2BHBA 4FLKA 3PKDA 4HXXA 2BWTA 2BB7A 1KQ0A 4QR8A 3PKAA
chains in the Genus database with same CATH superfamily
4FLJA 5D6EA 3BIQA 4U6ZA 4KM3A 2EVMA 2GGCA 2BH3A 2MATA 2BWUA 2Q8KA 2OKNA 2V3ZA 2BWYA 3BIPA 1WY2A 1C22A 2V3XA 4FO7A 4FKCA 5FCFA 3MATA 1BN5A 2OAZA 3RORA 2BHAA 2GTXA 4IKUA 5CE6A 1QXYA 2P9AA 3FMQA 3IU8A 3L24A 4IF7A 2GG3A 2V6CA 3MX6A 5JI6A 5CDEA 1XGNA 2EA4A 1WLRA 5CDVA 2Q96A 5E5BA 4PNCA 1YW9A 4ZWPA 3PKEA 3Q6DA 1C21A 4MATA 1JAWA 1CHMA 4Z7MA 1A16A 4U6EA 3FM3A 4U76A 2NQ6A 2BWVA 3IU7A 1W2MA 1WKMA 2GU4A 1M35A 1O0XA 3TAVA 4IECA 4ZWUA 1YW8A 1KP0A 1N51A 4IU6A 4U6JA 3S6BA 1XGOA 5CDLA 1XGSA 2GGBA 2HOWA 4ZWOA 4U73A 3RVAA 2Q95A 1C27A 1QXZA 4IPAA 2DFIA 4U69A 2G6PA 2Q94A 3D27A 2GG9A 1R58A 1XNZA 4FLIA 1MATA 4B28A 1C24A 3BITA 1C23A 4S2RP 5CIKA 3IG4A 3L7GA 4OOKA 2GU7A 5JHUA 1R5HA 5JFRA 4S2TP 2GG2A 4U75A 2B3HA 4EGEA 2P98A 2Q93A 2GG0A 2GU6A 2EVCA 4ZNGA 4A6VA 1W7VA 2BWWA 4FUKA 1PV9A 5CNXA 3IU9A 1BOAA 2B3KA 4R60A 4U70A 5CLSA 1KQ9A 3CTZA 2GZ5A 3PKCA 2EVOA 1WL9A 1YVMA 2NQ7A 1R5GA 3MR1A 4A6WA 1XGMA 2EA2A 3CB5A 2BN7A 3PKBA 4JUQA 2GG8A 4PV4A 4S01A 4RGZ1 5FCHA 2V3YA 2BHDA 2GA2A 3FMRA 4IDYA 2GG7A 4U6CA 2GG5A 4RZZA 2Q92A 4U1BA 1QZYA 1YW7A 3TB5A 1WBQA 4IKRA 4IKSA 1B6AA 4FO8A 1QXWA 1Y1NA 2B3LA 3CB6A 2P99A 1YJ3A 4RZYA 1B59A 2BWSA 4U6WA 2GU5A 4U71A 2BWXA 2BHCA 2ADUA 1WL6A 4S00A 2ZSGA 4IKTA 4FLLA 1WN1A 2IW2A 5D6FA 2BHBA 4FLKA 3PKDA 4HXXA 2BWTA 2BB7A 1KQ0A 4QR8A 3PKAA
chains in the Genus database with same CATH topology
4FLJA 5D6EA 3BIQA 4U6ZA 4KM3A 2EVMA 2GGCA 2BH3A 2MATA 2BWUA 2Q8KA 2OKNA 2V3ZA 2BWYA 3BIPA 1WY2A 1C22A 2V3XA 4FO7A 4FKCA 5FCFA 3MATA 1BN5A 2OAZA 3RORA 2BHAA 2GTXA 4IKUA 5CE6A 1QXYA 2P9AA 3FMQA 3IU8A 3L24A 4IF7A 2GG3A 2V6CA 3MX6A 5JI6A 5CDEA 1XGNA 2EA4A 1WLRA 5CDVA 2Q96A 5E5BA 4PNCA 1YW9A 4ZWPA 3PKEA 3Q6DA 1C21A 4MATA 1JAWA 1CHMA 4Z7MA 1A16A 4U6EA 3FM3A 4U76A 2NQ6A 2BWVA 3IU7A 1W2MA 1WKMA 2GU4A 1M35A 1O0XA 3TAVA 4IECA 4ZWUA 1YW8A 1KP0A 1N51A 4IU6A 4U6JA 3S6BA 1XGOA 5CDLA 1XGSA 2GGBA 2HOWA 4ZWOA 4U73A 3RVAA 2Q95A 1C27A 1QXZA 4IPAA 2DFIA 4U69A 2G6PA 2Q94A 3D27A 2GG9A 1R58A 1XNZA 4FLIA 1MATA 4B28A 1C24A 3BITA 1C23A 4S2RP 5CIKA 3IG4A 3L7GA 4OOKA 2GU7A 5JHUA 1R5HA 5JFRA 4S2TP 2GG2A 4U75A 2B3HA 4EGEA 2P98A 2Q93A 2GG0A 2GU6A 2EVCA 4ZNGA 4A6VA 1W7VA 2BWWA 4FUKA 1PV9A 5CNXA 3IU9A 1BOAA 2B3KA 4R60A 4U70A 5CLSA 1KQ9A 3CTZA 2GZ5A 3PKCA 2EVOA 1WL9A 1YVMA 2NQ7A 1R5GA 3MR1A 4A6WA 1XGMA 2EA2A 3CB5A 2BN7A 3PKBA 4JUQA 2GG8A 4PV4A 4S01A 4RGZ1 5FCHA 2V3YA 2BHDA 2GA2A 3FMRA 4IDYA 2GG7A 4U6CA 2GG5A 4RZZA 2Q92A 4U1BA 1QZYA 1YW7A 3TB5A 1WBQA 4IKRA 4IKSA 1B6AA 4FO8A 1QXWA 1Y1NA 2B3LA 3CB6A 2P99A 1YJ3A 4RZYA 1B59A 2BWSA 4U6WA 2GU5A 4U71A 2BWXA 2BHCA 2ADUA 1WL6A 4S00A 2ZSGA 4IKTA 4FLLA 1WN1A 2IW2A 5D6FA 2BHBA 4FLKA 3PKDA 4HXXA 2BWTA 2BB7A 1KQ0A 4QR8A 3PKAA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4FLJ A;  5D6E A;  3BIQ A;  4U6Z A;  4KM3 A;  2EVM A;  2GGC A;  2BH3 A;  2MAT A;  2BWU A;  2Q8K A;  2OKN A;  2V3Z A;  2BWY A;  3BIP A;  1WY2 A;  1C22 A;  2V3X A;  4FO7 A;  4FKC A;  5FCF A;  3MAT A;  1BN5 A;  2OAZ A;  3ROR A;  2BHA A;  2GTX A;  4IKU A;  5CE6 A;  1QXY A;  2P9A A;  3FMQ A;  3IU8 A;  3L24 A;  4IF7 A;  2GG3 A;  2V6C A;  3MX6 A;  5JI6 A;  5CDE A;  1XGN A;  2EA4 A;  1WLR A;  5CDV A;  2Q96 A;  5E5B A;  4PNC A;  1YW9 A;  4ZWP A;  3PKE A;  3Q6D A;  1C21 A;  4MAT A;  1JAW A;  1CHM A;  4Z7M A;  1A16 A;  4U6E A;  3FM3 A;  4U76 A;  2NQ6 A;  2BWV A;  3IU7 A;  1W2M A;  1WKM A;  2GU4 A;  1M35 A;  1O0X A;  3TAV A;  4IEC A;  4ZWU A;  1YW8 A;  1KP0 A;  1N51 A;  4IU6 A;  4U6J A;  3S6B A;  1XGO A;  5CDL A;  1XGS A;  2GGB A;  2HOW A;  4ZWO A;  4U73 A;  3RVA A;  2Q95 A;  1C27 A;  1QXZ A;  4IPA A;  2DFI A;  4U69 A;  2G6P A;  2Q94 A;  3D27 A;  2GG9 A;  1R58 A;  1XNZ A;  4FLI A;  1MAT A;  4B28 A;  1C24 A;  3BIT A;  1C23 A;  4S2R P;  5CIK A;  3IG4 A;  3L7G A;  4OOK A;  2GU7 A;  5JHU A;  1R5H A;  5JFR A;  4S2T P;  2GG2 A;  4U75 A;  2B3H A;  4EGE A;  2P98 A;  2Q93 A;  2GG0 A;  2GU6 A;  2EVC A;  4ZNG A;  4A6V A;  1W7V A;  2BWW A;  4FUK A;  1PV9 A;  5CNX A;  3IU9 A;  1BOA A;  2B3K A;  4R60 A;  4U70 A;  5CLS A;  1KQ9 A;  3CTZ A;  2GZ5 A;  3PKC A;  2EVO A;  1WL9 A;  1YVM A;  2NQ7 A;  1R5G A;  3MR1 A;  4A6W A;  1XGM A;  2EA2 A;  3CB5 A;  2BN7 A;  3PKB A;  4JUQ A;  2GG8 A;  4PV4 A;  4S01 A;  4RGZ 1;  5FCH A;  2V3Y A;  2BHD A;  2GA2 A;  3FMR A;  4IDY A;  2GG7 A;  4U6C A;  2GG5 A;  4RZZ A;  2Q92 A;  4U1B A;  1QZY A;  1YW7 A;  3TB5 A;  1WBQ A;  4IKR A;  4IKS A;  1B6A A;  4FO8 A;  1QXW A;  1Y1N A;  2B3L A;  3CB6 A;  2P99 A;  1YJ3 A;  4RZY A;  1B59 A;  2BWS A;  4U6W A;  2GU5 A;  4U71 A;  2BWX A;  2BHC A;  2ADU A;  1WL6 A;  4S00 A;  2ZSG A;  4IKT A;  4FLL A;  1WN1 A;  2IW2 A;  5D6F A;  2BHB A;  4FLK A;  3PKD A;  4HXX A;  2BWT A;  2BB7 A;  1KQ0 A;  4QR8 A;  3PKA A; 
#chains in the Genus database with same CATH topology
 4FLJ A;  5D6E A;  3BIQ A;  4U6Z A;  4KM3 A;  2EVM A;  2GGC A;  2BH3 A;  2MAT A;  2BWU A;  2Q8K A;  2OKN A;  2V3Z A;  2BWY A;  3BIP A;  1WY2 A;  1C22 A;  2V3X A;  4FO7 A;  4FKC A;  5FCF A;  3MAT A;  1BN5 A;  2OAZ A;  3ROR A;  2BHA A;  2GTX A;  4IKU A;  5CE6 A;  1QXY A;  2P9A A;  3FMQ A;  3IU8 A;  3L24 A;  4IF7 A;  2GG3 A;  2V6C A;  3MX6 A;  5JI6 A;  5CDE A;  1XGN A;  2EA4 A;  1WLR A;  5CDV A;  2Q96 A;  5E5B A;  4PNC A;  1YW9 A;  4ZWP A;  3PKE A;  3Q6D A;  1C21 A;  4MAT A;  1JAW A;  1CHM A;  4Z7M A;  1A16 A;  4U6E A;  3FM3 A;  4U76 A;  2NQ6 A;  2BWV A;  3IU7 A;  1W2M A;  1WKM A;  2GU4 A;  1M35 A;  1O0X A;  3TAV A;  4IEC A;  4ZWU A;  1YW8 A;  1KP0 A;  1N51 A;  4IU6 A;  4U6J A;  3S6B A;  1XGO A;  5CDL A;  1XGS A;  2GGB A;  2HOW A;  4ZWO A;  4U73 A;  3RVA A;  2Q95 A;  1C27 A;  1QXZ A;  4IPA A;  2DFI A;  4U69 A;  2G6P A;  2Q94 A;  3D27 A;  2GG9 A;  1R58 A;  1XNZ A;  4FLI A;  1MAT A;  4B28 A;  1C24 A;  3BIT A;  1C23 A;  4S2R P;  5CIK A;  3IG4 A;  3L7G A;  4OOK A;  2GU7 A;  5JHU A;  1R5H A;  5JFR A;  4S2T P;  2GG2 A;  4U75 A;  2B3H A;  4EGE A;  2P98 A;  2Q93 A;  2GG0 A;  2GU6 A;  2EVC A;  4ZNG A;  4A6V A;  1W7V A;  2BWW A;  4FUK A;  1PV9 A;  5CNX A;  3IU9 A;  1BOA A;  2B3K A;  4R60 A;  4U70 A;  5CLS A;  1KQ9 A;  3CTZ A;  2GZ5 A;  3PKC A;  2EVO A;  1WL9 A;  1YVM A;  2NQ7 A;  1R5G A;  3MR1 A;  4A6W A;  1XGM A;  2EA2 A;  3CB5 A;  2BN7 A;  3PKB A;  4JUQ A;  2GG8 A;  4PV4 A;  4S01 A;  4RGZ 1;  5FCH A;  2V3Y A;  2BHD A;  2GA2 A;  3FMR A;  4IDY A;  2GG7 A;  4U6C A;  2GG5 A;  4RZZ A;  2Q92 A;  4U1B A;  1QZY A;  1YW7 A;  3TB5 A;  1WBQ A;  4IKR A;  4IKS A;  1B6A A;  4FO8 A;  1QXW A;  1Y1N A;  2B3L A;  3CB6 A;  2P99 A;  1YJ3 A;  4RZY A;  1B59 A;  2BWS A;  4U6W A;  2GU5 A;  4U71 A;  2BWX A;  2BHC A;  2ADU A;  1WL6 A;  4S00 A;  2ZSG A;  4IKT A;  4FLL A;  1WN1 A;  2IW2 A;  5D6F A;  2BHB A;  4FLK A;  3PKD A;  4HXX A;  2BWT A;  2BB7 A;  1KQ0 A;  4QR8 A;  3PKA A; 
#chains in the Genus database with same CATH homology
 4FLJ A;  5D6E A;  3BIQ A;  4U6Z A;  4KM3 A;  2EVM A;  2GGC A;  2BH3 A;  2MAT A;  2BWU A;  2Q8K A;  2OKN A;  2V3Z A;  2BWY A;  3BIP A;  1WY2 A;  1C22 A;  2V3X A;  4FO7 A;  4FKC A;  5FCF A;  3MAT A;  1BN5 A;  2OAZ A;  3ROR A;  2BHA A;  2GTX A;  4IKU A;  5CE6 A;  1QXY A;  2P9A A;  3FMQ A;  3IU8 A;  3L24 A;  4IF7 A;  2GG3 A;  2V6C A;  3MX6 A;  5JI6 A;  5CDE A;  1XGN A;  2EA4 A;  1WLR A;  5CDV A;  2Q96 A;  5E5B A;  4PNC A;  1YW9 A;  4ZWP A;  3PKE A;  3Q6D A;  1C21 A;  4MAT A;  1JAW A;  1CHM A;  4Z7M A;  1A16 A;  4U6E A;  3FM3 A;  4U76 A;  2NQ6 A;  2BWV A;  3IU7 A;  1W2M A;  1WKM A;  2GU4 A;  1M35 A;  1O0X A;  3TAV A;  4IEC A;  4ZWU A;  1YW8 A;  1KP0 A;  1N51 A;  4IU6 A;  4U6J A;  3S6B A;  1XGO A;  5CDL A;  1XGS A;  2GGB A;  2HOW A;  4ZWO A;  4U73 A;  3RVA A;  2Q95 A;  1C27 A;  1QXZ A;  4IPA A;  2DFI A;  4U69 A;  2G6P A;  2Q94 A;  3D27 A;  2GG9 A;  1R58 A;  1XNZ A;  4FLI A;  1MAT A;  4B28 A;  1C24 A;  3BIT A;  1C23 A;  4S2R P;  5CIK A;  3IG4 A;  3L7G A;  4OOK A;  2GU7 A;  5JHU A;  1R5H A;  5JFR A;  4S2T P;  2GG2 A;  4U75 A;  2B3H A;  4EGE A;  2P98 A;  2Q93 A;  2GG0 A;  2GU6 A;  2EVC A;  4ZNG A;  4A6V A;  1W7V A;  2BWW A;  4FUK A;  1PV9 A;  5CNX A;  3IU9 A;  1BOA A;  2B3K A;  4R60 A;  4U70 A;  5CLS A;  1KQ9 A;  3CTZ A;  2GZ5 A;  3PKC A;  2EVO A;  1WL9 A;  1YVM A;  2NQ7 A;  1R5G A;  3MR1 A;  4A6W A;  1XGM A;  2EA2 A;  3CB5 A;  2BN7 A;  3PKB A;  4JUQ A;  2GG8 A;  4PV4 A;  4S01 A;  4RGZ 1;  5FCH A;  2V3Y A;  2BHD A;  2GA2 A;  3FMR A;  4IDY A;  2GG7 A;  4U6C A;  2GG5 A;  4RZZ A;  2Q92 A;  4U1B A;  1QZY A;  1YW7 A;  3TB5 A;  1WBQ A;  4IKR A;  4IKS A;  1B6A A;  4FO8 A;  1QXW A;  1Y1N A;  2B3L A;  3CB6 A;  2P99 A;  1YJ3 A;  4RZY A;  1B59 A;  2BWS A;  4U6W A;  2GU5 A;  4U71 A;  2BWX A;  2BHC A;  2ADU A;  1WL6 A;  4S00 A;  2ZSG A;  4IKT A;  4FLL A;  1WN1 A;  2IW2 A;  5D6F A;  2BHB A;  4FLK A;  3PKD A;  4HXX A;  2BWT A;  2BB7 A;  1KQ0 A;  4QR8 A;  3PKA A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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