2P9AA

E. coli methionine aminopeptidase dimetalated with inhibitor ye6
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule keywords Methionine aminopeptidase
publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
source organism Escherichia coli
molecule tags Hydrolase
total genus 83
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p9aA00
4U69A 3CB6A 1YJ3A 3D27A 1QXZA 1R5HA 4PV4A 2GG5A 1C21A 5JFRA 2GA2A 3FMRA 4U76A 2V3ZA 2GZ5A 4MATA 2GU7A 4S00A 2NQ6A 4FLKA 1WKMA 2DFIA 3IU9A 1YW9A 2OAZA 2BWYA 1QXYA 2Q96A 3IG4A 1R5GA 1QZYA 2GG8A 2GTXA 2V3YA 3PKAA 3S6BA 2G6PA 1KP0A 3PKCA 2B3KA 1CHMA 2BWWA 3L24A 4S2TP 3FMQA 1N51A 4IPAA 2ADUA 2EVMA 2BWVA 3MATA 2Q92A 2V6CA 4U70A 4FKCA 2BHCA 4A6VA 3TAVA 4RZYA 4ZWOA 1B59A 2ZSGA 4U6ZA 2EA2A 2P98A 1XGNA 4U1BA 1KQ9A 2OKNA 5JHUA 1YW8A 2BWUA 3BIQA 5FCFA 2GG3A 1M35A 5CDLA 4S2RP 2IW2A 4FLLA 2GG7A 5CIKA 4IKUA 4ZWPA 1MATA 4FLJA 4A6WA 1O0XA 2BHDA 3FM3A 1R58A 3MR1A 2GGCA 1B6AA 4S01A 1WL9A 4IU6A 1WL6A 4OOKA 4RZZA 4ZNGA 4ZWUA 4IKRA 2HOWA 2BWSA 4FO7A 2BHBA 1W7VA 2EA4A 2GG0A 4IKSA 4U73A 4U71A 5CDVA 1BOAA 1JAWA 1C22A 1WY2A 1C23A 2Q94A 4PNCA 2Q93A 2GU6A 5CDEA 2GG2A 2P99A 2BWTA 4R60A 5D6EA 1W2MA 1WLRA 2GU4A 3RVAA 5JI6A 2BN7A 5FCHA 4U6WA 4U6EA 1C24A 2BHAA 3L7GA 2GU5A 3PKEA 2Q95A 1XGSA 4IDYA 4U75A 1YVMA 3PKDA 2BH3A 1QXWA 2V3XA 3CTZA 4KM3A 3PKBA 4B28A 4U6JA 1KQ0A 1PV9A 1XGMA 1BN5A 1XNZA 2P9AA 3IU7A 4QR8A 1Y1NA 3BIPA 4RGZ1 4U6CA 5D6FA 5CE6A 4FO8A 5CNXA 4IKTA 1YW7A 4EGEA 1WN1A 2BWXA 3RORA 5E5BA 4Z7MA 3TB5A 4FLIA 3IU8A 4IECA 2MATA 4FUKA 1C27A 3CB5A 4JUQA 2BB7A 2GGBA 2EVCA 4HXXA 2B3HA 2GG9A 1A16A 1WBQA 3BITA 2EVOA 2Q8KA 3MX6A 5CLSA 2NQ7A 4IF7A 1XGOA 3Q6DA 2B3LA
chains in the Genus database with same CATH superfamily
4U69A 3CB6A 1YJ3A 3D27A 1QXZA 1R5HA 4PV4A 2GG5A 1C21A 5JFRA 2GA2A 3FMRA 4U76A 2V3ZA 2GZ5A 4MATA 2GU7A 4S00A 2NQ6A 4FLKA 1WKMA 2DFIA 3IU9A 1YW9A 2OAZA 2BWYA 1QXYA 2Q96A 3IG4A 1R5GA 1QZYA 2GG8A 2GTXA 2V3YA 3PKAA 3S6BA 2G6PA 1KP0A 3PKCA 2B3KA 1CHMA 2BWWA 3L24A 4S2TP 3FMQA 1N51A 4IPAA 2ADUA 2EVMA 2BWVA 3MATA 2Q92A 2V6CA 4U70A 4FKCA 2BHCA 4A6VA 3TAVA 4RZYA 4ZWOA 1B59A 2ZSGA 4U6ZA 2EA2A 2P98A 1XGNA 4U1BA 1KQ9A 2OKNA 5JHUA 1YW8A 2BWUA 3BIQA 5FCFA 2GG3A 1M35A 5CDLA 4S2RP 2IW2A 4FLLA 2GG7A 5CIKA 4IKUA 4ZWPA 1MATA 4FLJA 4A6WA 1O0XA 2BHDA 3FM3A 1R58A 3MR1A 2GGCA 1B6AA 4S01A 1WL9A 4IU6A 1WL6A 4OOKA 4RZZA 4ZNGA 4ZWUA 4IKRA 2HOWA 2BWSA 4FO7A 2BHBA 1W7VA 2EA4A 2GG0A 4IKSA 4U73A 4U71A 5CDVA 1BOAA 1JAWA 1C22A 1WY2A 1C23A 2Q94A 4PNCA 2Q93A 2GU6A 5CDEA 2GG2A 2P99A 2BWTA 4R60A 5D6EA 1W2MA 1WLRA 2GU4A 3RVAA 5JI6A 2BN7A 5FCHA 4U6WA 4U6EA 1C24A 2BHAA 3L7GA 2GU5A 3PKEA 2Q95A 1XGSA 4IDYA 4U75A 1YVMA 3PKDA 2BH3A 1QXWA 2V3XA 3CTZA 4KM3A 3PKBA 4B28A 4U6JA 1KQ0A 1PV9A 1XGMA 1BN5A 1XNZA 2P9AA 3IU7A 4QR8A 1Y1NA 3BIPA 4RGZ1 4U6CA 5D6FA 5CE6A 4FO8A 5CNXA 4IKTA 1YW7A 4EGEA 1WN1A 2BWXA 3RORA 5E5BA 4Z7MA 3TB5A 4FLIA 3IU8A 4IECA 2MATA 4FUKA 1C27A 3CB5A 4JUQA 2BB7A 2GGBA 2EVCA 4HXXA 2B3HA 2GG9A 1A16A 1WBQA 3BITA 2EVOA 2Q8KA 3MX6A 5CLSA 2NQ7A 4IF7A 1XGOA 3Q6DA 2B3LA
chains in the Genus database with same CATH topology
4U69A 3CB6A 1YJ3A 3D27A 1QXZA 1R5HA 4PV4A 2GG5A 1C21A 5JFRA 2GA2A 3FMRA 4U76A 2V3ZA 2GZ5A 4MATA 2GU7A 4S00A 2NQ6A 4FLKA 1WKMA 2DFIA 3IU9A 1YW9A 2OAZA 2BWYA 1QXYA 2Q96A 3IG4A 1R5GA 1QZYA 2GG8A 2GTXA 2V3YA 3PKAA 3S6BA 2G6PA 1KP0A 3PKCA 2B3KA 1CHMA 2BWWA 3L24A 4S2TP 3FMQA 1N51A 4IPAA 2ADUA 2EVMA 2BWVA 3MATA 2Q92A 2V6CA 4U70A 4FKCA 2BHCA 4A6VA 3TAVA 4RZYA 4ZWOA 1B59A 2ZSGA 4U6ZA 2EA2A 2P98A 1XGNA 4U1BA 1KQ9A 2OKNA 5JHUA 1YW8A 2BWUA 3BIQA 5FCFA 2GG3A 1M35A 5CDLA 4S2RP 2IW2A 4FLLA 2GG7A 5CIKA 4IKUA 4ZWPA 1MATA 4FLJA 4A6WA 1O0XA 2BHDA 3FM3A 1R58A 3MR1A 2GGCA 1B6AA 4S01A 1WL9A 4IU6A 1WL6A 4OOKA 4RZZA 4ZNGA 4ZWUA 4IKRA 2HOWA 2BWSA 4FO7A 2BHBA 1W7VA 2EA4A 2GG0A 4IKSA 4U73A 4U71A 5CDVA 1BOAA 1JAWA 1C22A 1WY2A 1C23A 2Q94A 4PNCA 2Q93A 2GU6A 5CDEA 2GG2A 2P99A 2BWTA 4R60A 5D6EA 1W2MA 1WLRA 2GU4A 3RVAA 5JI6A 2BN7A 5FCHA 4U6WA 4U6EA 1C24A 2BHAA 3L7GA 2GU5A 3PKEA 2Q95A 1XGSA 4IDYA 4U75A 1YVMA 3PKDA 2BH3A 1QXWA 2V3XA 3CTZA 4KM3A 3PKBA 4B28A 4U6JA 1KQ0A 1PV9A 1XGMA 1BN5A 1XNZA 2P9AA 3IU7A 4QR8A 1Y1NA 3BIPA 4RGZ1 4U6CA 5D6FA 5CE6A 4FO8A 5CNXA 4IKTA 1YW7A 4EGEA 1WN1A 2BWXA 3RORA 5E5BA 4Z7MA 3TB5A 4FLIA 3IU8A 4IECA 2MATA 4FUKA 1C27A 3CB5A 4JUQA 2BB7A 2GGBA 2EVCA 4HXXA 2B3HA 2GG9A 1A16A 1WBQA 3BITA 2EVOA 2Q8KA 3MX6A 5CLSA 2NQ7A 4IF7A 1XGOA 3Q6DA 2B3LA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4U69 A;  3CB6 A;  1YJ3 A;  3D27 A;  1QXZ A;  1R5H A;  4PV4 A;  2GG5 A;  1C21 A;  5JFR A;  2GA2 A;  3FMR A;  4U76 A;  2V3Z A;  2GZ5 A;  4MAT A;  2GU7 A;  4S00 A;  2NQ6 A;  4FLK A;  1WKM A;  2DFI A;  3IU9 A;  1YW9 A;  2OAZ A;  2BWY A;  1QXY A;  2Q96 A;  3IG4 A;  1R5G A;  1QZY A;  2GG8 A;  2GTX A;  2V3Y A;  3PKA A;  3S6B A;  2G6P A;  1KP0 A;  3PKC A;  2B3K A;  1CHM A;  2BWW A;  3L24 A;  4S2T P;  3FMQ A;  1N51 A;  4IPA A;  2ADU A;  2EVM A;  2BWV A;  3MAT A;  2Q92 A;  2V6C A;  4U70 A;  4FKC A;  2BHC A;  4A6V A;  3TAV A;  4RZY A;  4ZWO A;  1B59 A;  2ZSG A;  4U6Z A;  2EA2 A;  2P98 A;  1XGN A;  4U1B A;  1KQ9 A;  2OKN A;  5JHU A;  1YW8 A;  2BWU A;  3BIQ A;  5FCF A;  2GG3 A;  1M35 A;  5CDL A;  4S2R P;  2IW2 A;  4FLL A;  2GG7 A;  5CIK A;  4IKU A;  4ZWP A;  1MAT A;  4FLJ A;  4A6W A;  1O0X A;  2BHD A;  3FM3 A;  1R58 A;  3MR1 A;  2GGC A;  1B6A A;  4S01 A;  1WL9 A;  4IU6 A;  1WL6 A;  4OOK A;  4RZZ A;  4ZNG A;  4ZWU A;  4IKR A;  2HOW A;  2BWS A;  4FO7 A;  2BHB A;  1W7V A;  2EA4 A;  2GG0 A;  4IKS A;  4U73 A;  4U71 A;  5CDV A;  1BOA A;  1JAW A;  1C22 A;  1WY2 A;  1C23 A;  2Q94 A;  4PNC A;  2Q93 A;  2GU6 A;  5CDE A;  2GG2 A;  2P99 A;  2BWT A;  4R60 A;  5D6E A;  1W2M A;  1WLR A;  2GU4 A;  3RVA A;  5JI6 A;  2BN7 A;  5FCH A;  4U6W A;  4U6E A;  1C24 A;  2BHA A;  3L7G A;  2GU5 A;  3PKE A;  2Q95 A;  1XGS A;  4IDY A;  4U75 A;  1YVM A;  3PKD A;  2BH3 A;  1QXW A;  2V3X A;  3CTZ A;  4KM3 A;  3PKB A;  4B28 A;  4U6J A;  1KQ0 A;  1PV9 A;  1XGM A;  1BN5 A;  1XNZ A;  2P9A A;  3IU7 A;  4QR8 A;  1Y1N A;  3BIP A;  4RGZ 1;  4U6C A;  5D6F A;  5CE6 A;  4FO8 A;  5CNX A;  4IKT A;  1YW7 A;  4EGE A;  1WN1 A;  2BWX A;  3ROR A;  5E5B A;  4Z7M A;  3TB5 A;  4FLI A;  3IU8 A;  4IEC A;  2MAT A;  4FUK A;  1C27 A;  3CB5 A;  4JUQ A;  2BB7 A;  2GGB A;  2EVC A;  4HXX A;  2B3H A;  2GG9 A;  1A16 A;  1WBQ A;  3BIT A;  2EVO A;  2Q8K A;  3MX6 A;  5CLS A;  2NQ7 A;  4IF7 A;  1XGO A;  3Q6D A;  2B3L A; 
#chains in the Genus database with same CATH topology
 4U69 A;  3CB6 A;  1YJ3 A;  3D27 A;  1QXZ A;  1R5H A;  4PV4 A;  2GG5 A;  1C21 A;  5JFR A;  2GA2 A;  3FMR A;  4U76 A;  2V3Z A;  2GZ5 A;  4MAT A;  2GU7 A;  4S00 A;  2NQ6 A;  4FLK A;  1WKM A;  2DFI A;  3IU9 A;  1YW9 A;  2OAZ A;  2BWY A;  1QXY A;  2Q96 A;  3IG4 A;  1R5G A;  1QZY A;  2GG8 A;  2GTX A;  2V3Y A;  3PKA A;  3S6B A;  2G6P A;  1KP0 A;  3PKC A;  2B3K A;  1CHM A;  2BWW A;  3L24 A;  4S2T P;  3FMQ A;  1N51 A;  4IPA A;  2ADU A;  2EVM A;  2BWV A;  3MAT A;  2Q92 A;  2V6C A;  4U70 A;  4FKC A;  2BHC A;  4A6V A;  3TAV A;  4RZY A;  4ZWO A;  1B59 A;  2ZSG A;  4U6Z A;  2EA2 A;  2P98 A;  1XGN A;  4U1B A;  1KQ9 A;  2OKN A;  5JHU A;  1YW8 A;  2BWU A;  3BIQ A;  5FCF A;  2GG3 A;  1M35 A;  5CDL A;  4S2R P;  2IW2 A;  4FLL A;  2GG7 A;  5CIK A;  4IKU A;  4ZWP A;  1MAT A;  4FLJ A;  4A6W A;  1O0X A;  2BHD A;  3FM3 A;  1R58 A;  3MR1 A;  2GGC A;  1B6A A;  4S01 A;  1WL9 A;  4IU6 A;  1WL6 A;  4OOK A;  4RZZ A;  4ZNG A;  4ZWU A;  4IKR A;  2HOW A;  2BWS A;  4FO7 A;  2BHB A;  1W7V A;  2EA4 A;  2GG0 A;  4IKS A;  4U73 A;  4U71 A;  5CDV A;  1BOA A;  1JAW A;  1C22 A;  1WY2 A;  1C23 A;  2Q94 A;  4PNC A;  2Q93 A;  2GU6 A;  5CDE A;  2GG2 A;  2P99 A;  2BWT A;  4R60 A;  5D6E A;  1W2M A;  1WLR A;  2GU4 A;  3RVA A;  5JI6 A;  2BN7 A;  5FCH A;  4U6W A;  4U6E A;  1C24 A;  2BHA A;  3L7G A;  2GU5 A;  3PKE A;  2Q95 A;  1XGS A;  4IDY A;  4U75 A;  1YVM A;  3PKD A;  2BH3 A;  1QXW A;  2V3X A;  3CTZ A;  4KM3 A;  3PKB A;  4B28 A;  4U6J A;  1KQ0 A;  1PV9 A;  1XGM A;  1BN5 A;  1XNZ A;  2P9A A;  3IU7 A;  4QR8 A;  1Y1N A;  3BIP A;  4RGZ 1;  4U6C A;  5D6F A;  5CE6 A;  4FO8 A;  5CNX A;  4IKT A;  1YW7 A;  4EGE A;  1WN1 A;  2BWX A;  3ROR A;  5E5B A;  4Z7M A;  3TB5 A;  4FLI A;  3IU8 A;  4IEC A;  2MAT A;  4FUK A;  1C27 A;  3CB5 A;  4JUQ A;  2BB7 A;  2GGB A;  2EVC A;  4HXX A;  2B3H A;  2GG9 A;  1A16 A;  1WBQ A;  3BIT A;  2EVO A;  2Q8K A;  3MX6 A;  5CLS A;  2NQ7 A;  4IF7 A;  1XGO A;  3Q6D A;  2B3L A; 
#chains in the Genus database with same CATH homology
 4U69 A;  3CB6 A;  1YJ3 A;  3D27 A;  1QXZ A;  1R5H A;  4PV4 A;  2GG5 A;  1C21 A;  5JFR A;  2GA2 A;  3FMR A;  4U76 A;  2V3Z A;  2GZ5 A;  4MAT A;  2GU7 A;  4S00 A;  2NQ6 A;  4FLK A;  1WKM A;  2DFI A;  3IU9 A;  1YW9 A;  2OAZ A;  2BWY A;  1QXY A;  2Q96 A;  3IG4 A;  1R5G A;  1QZY A;  2GG8 A;  2GTX A;  2V3Y A;  3PKA A;  3S6B A;  2G6P A;  1KP0 A;  3PKC A;  2B3K A;  1CHM A;  2BWW A;  3L24 A;  4S2T P;  3FMQ A;  1N51 A;  4IPA A;  2ADU A;  2EVM A;  2BWV A;  3MAT A;  2Q92 A;  2V6C A;  4U70 A;  4FKC A;  2BHC A;  4A6V A;  3TAV A;  4RZY A;  4ZWO A;  1B59 A;  2ZSG A;  4U6Z A;  2EA2 A;  2P98 A;  1XGN A;  4U1B A;  1KQ9 A;  2OKN A;  5JHU A;  1YW8 A;  2BWU A;  3BIQ A;  5FCF A;  2GG3 A;  1M35 A;  5CDL A;  4S2R P;  2IW2 A;  4FLL A;  2GG7 A;  5CIK A;  4IKU A;  4ZWP A;  1MAT A;  4FLJ A;  4A6W A;  1O0X A;  2BHD A;  3FM3 A;  1R58 A;  3MR1 A;  2GGC A;  1B6A A;  4S01 A;  1WL9 A;  4IU6 A;  1WL6 A;  4OOK A;  4RZZ A;  4ZNG A;  4ZWU A;  4IKR A;  2HOW A;  2BWS A;  4FO7 A;  2BHB A;  1W7V A;  2EA4 A;  2GG0 A;  4IKS A;  4U73 A;  4U71 A;  5CDV A;  1BOA A;  1JAW A;  1C22 A;  1WY2 A;  1C23 A;  2Q94 A;  4PNC A;  2Q93 A;  2GU6 A;  5CDE A;  2GG2 A;  2P99 A;  2BWT A;  4R60 A;  5D6E A;  1W2M A;  1WLR A;  2GU4 A;  3RVA A;  5JI6 A;  2BN7 A;  5FCH A;  4U6W A;  4U6E A;  1C24 A;  2BHA A;  3L7G A;  2GU5 A;  3PKE A;  2Q95 A;  1XGS A;  4IDY A;  4U75 A;  1YVM A;  3PKD A;  2BH3 A;  1QXW A;  2V3X A;  3CTZ A;  4KM3 A;  3PKB A;  4B28 A;  4U6J A;  1KQ0 A;  1PV9 A;  1XGM A;  1BN5 A;  1XNZ A;  2P9A A;  3IU7 A;  4QR8 A;  1Y1N A;  3BIP A;  4RGZ 1;  4U6C A;  5D6F A;  5CE6 A;  4FO8 A;  5CNX A;  4IKT A;  1YW7 A;  4EGE A;  1WN1 A;  2BWX A;  3ROR A;  5E5B A;  4Z7M A;  3TB5 A;  4FLI A;  3IU8 A;  4IEC A;  2MAT A;  4FUK A;  1C27 A;  3CB5 A;  4JUQ A;  2BB7 A;  2GGB A;  2EVC A;  4HXX A;  2B3H A;  2GG9 A;  1A16 A;  1WBQ A;  3BIT A;  2EVO A;  2Q8K A;  3MX6 A;  5CLS A;  2NQ7 A;  4IF7 A;  1XGO A;  3Q6D A;  2B3L A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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