2P9AA

E. coli methionine aminopeptidase dimetalated with inhibitor ye6
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Escherichia coli
total genus 83
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p9aA00
1W7VA 5JFRA 1QXYA 2V3YA 5CNXA 1R5HA 1YJ3A 2B3LA 2V3ZA 5FCFA 4JUQA 2BWXA 3PKDA 2B3KA 4U75A 4U6WA 2BWYA 5CDEA 2P98A 4R60A 5FCHA 1PV9A 1WBQA 2Q95A 1WL9A 3IU8A 4S00A 2BN7A 2HOWA 4FLJA 2GG3A 2GU6A 2EA4A 2EVMA 2G6PA 2GG8A 3MATA 1C23A 1R58A 2P99A 1WLRA 1KQ0A 1WKMA 1XGMA 2EVOA 3FM3A 3PKEA 4IKUA 1WY2A 5JHUA 3BITA 2EA2A 2V6CA 3L24A 2Q93A 4U76A 1Y1NA 2BHAA 1CHMA 1MATA 4FO8A 4U1BA 3IU7A 4RZZA 2Q8KA 4S01A 3TAVA 4A6VA 3IU9A 4KM3A 4ZWPA 4U6EA 2GG2A 4IF7A 2GU4A 1YW7A 2GU7A 5CE6A 4U70A 5CIKA 2BWVA 2GTXA 5JI6A 3PKAA 4IKSA 1YW9A 3TB5A 1QZYA 2DFIA 1W2MA 2BHCA 4FLLA 2GZ5A 4IKRA 5CLSA 2Q94A 3MR1A 3L7GA 4HXXA 2EVCA 3CB6A 1C24A 2GGCA 1B59A 1XGOA 1QXZA 4OOKA 2BHBA 4RZYA 2P9AA 1KQ9A 1R5GA 1XGNA 2ADUA 2BH3A 2GG7A 4Z7MA 4IPAA 3S6BA 4U73A 5CDLA 1BN5A 2ZSGA 4S2TP 3CTZA 4ZWOA 1N51A 2GU5A 4PV4A 4EGEA 1C27A 5CDVA 3BIPA 1WL6A 1C22A 2GG9A 3MX6A 4PNCA 1BOAA 4A6WA 4FO7A 4U6JA 1O0XA 2NQ6A 2BWSA 2GA2A 1JAWA 1QXWA 2B3HA 2BWWA 4U6CA 2Q92A 3PKBA 2GGBA 4ZNGA 2V3XA 4ZWUA 2BB7A 3CB5A 4IU6A 3RORA 4FLKA 1YW8A 3FMQA 5D6EA 2GG5A 1M35A 2OAZA 4IKTA 2BHDA 4S2RP 3Q6DA 5E5BA 1XGSA 3PKCA 3RVAA 3IG4A 3BIQA 4QR8A 3D27A 4FKCA 4RGZ1 4FLIA 1YVMA 4IECA 2GG0A 2Q96A 4IDYA 4U69A 5D6FA 1KP0A 2BWUA 3FMRA 1WN1A 4MATA 1C21A 4B28A 2IW2A 1A16A 2MATA 4FUKA 1B6AA 2NQ7A 4U6ZA 2BWTA 1XNZA 4U71A 2OKNA
chains in the Genus database with same CATH superfamily
1W7VA 5JFRA 1QXYA 2V3YA 5CNXA 1R5HA 1YJ3A 2B3LA 2V3ZA 5FCFA 4JUQA 2BWXA 3PKDA 2B3KA 4U75A 4U6WA 2BWYA 5CDEA 2P98A 4R60A 5FCHA 1PV9A 1WBQA 2Q95A 1WL9A 3IU8A 4S00A 2BN7A 2HOWA 4FLJA 2GG3A 2GU6A 2EA4A 2EVMA 2G6PA 2GG8A 3MATA 1C23A 1R58A 2P99A 1WLRA 1KQ0A 1WKMA 1XGMA 2EVOA 3FM3A 3PKEA 4IKUA 1WY2A 5JHUA 3BITA 2EA2A 2V6CA 3L24A 2Q93A 4U76A 1Y1NA 2BHAA 1CHMA 1MATA 4FO8A 4U1BA 3IU7A 4RZZA 2Q8KA 4S01A 3TAVA 4A6VA 3IU9A 4KM3A 4ZWPA 4U6EA 2GG2A 4IF7A 2GU4A 1YW7A 2GU7A 5CE6A 4U70A 5CIKA 2BWVA 2GTXA 5JI6A 3PKAA 4IKSA 1YW9A 3TB5A 1QZYA 2DFIA 1W2MA 2BHCA 4FLLA 2GZ5A 4IKRA 5CLSA 2Q94A 3MR1A 3L7GA 4HXXA 2EVCA 3CB6A 1C24A 2GGCA 1B59A 1XGOA 1QXZA 4OOKA 2BHBA 4RZYA 2P9AA 1KQ9A 1R5GA 1XGNA 2ADUA 2BH3A 2GG7A 4Z7MA 4IPAA 3S6BA 4U73A 5CDLA 1BN5A 2ZSGA 4S2TP 3CTZA 4ZWOA 1N51A 2GU5A 4PV4A 4EGEA 1C27A 5CDVA 3BIPA 1WL6A 1C22A 2GG9A 3MX6A 4PNCA 1BOAA 4A6WA 4FO7A 4U6JA 1O0XA 2NQ6A 2BWSA 2GA2A 1JAWA 1QXWA 2B3HA 2BWWA 4U6CA 2Q92A 3PKBA 2GGBA 4ZNGA 2V3XA 4ZWUA 2BB7A 3CB5A 4IU6A 3RORA 4FLKA 1YW8A 3FMQA 5D6EA 2GG5A 1M35A 2OAZA 4IKTA 2BHDA 4S2RP 3Q6DA 5E5BA 1XGSA 3PKCA 3RVAA 3IG4A 3BIQA 4QR8A 3D27A 4FKCA 4RGZ1 4FLIA 1YVMA 4IECA 2GG0A 2Q96A 4IDYA 4U69A 5D6FA 1KP0A 2BWUA 3FMRA 1WN1A 4MATA 1C21A 4B28A 2IW2A 1A16A 2MATA 4FUKA 1B6AA 2NQ7A 4U6ZA 2BWTA 1XNZA 4U71A 2OKNA
chains in the Genus database with same CATH topology
1W7VA 5JFRA 1QXYA 2V3YA 5CNXA 1R5HA 1YJ3A 2B3LA 2V3ZA 5FCFA 4JUQA 2BWXA 3PKDA 2B3KA 4U75A 4U6WA 2BWYA 5CDEA 2P98A 4R60A 5FCHA 1PV9A 1WBQA 2Q95A 1WL9A 3IU8A 4S00A 2BN7A 2HOWA 4FLJA 2GG3A 2GU6A 2EA4A 2EVMA 2G6PA 2GG8A 3MATA 1C23A 1R58A 2P99A 1WLRA 1KQ0A 1WKMA 1XGMA 2EVOA 3FM3A 3PKEA 4IKUA 1WY2A 5JHUA 3BITA 2EA2A 2V6CA 3L24A 2Q93A 4U76A 1Y1NA 2BHAA 1CHMA 1MATA 4FO8A 4U1BA 3IU7A 4RZZA 2Q8KA 4S01A 3TAVA 4A6VA 3IU9A 4KM3A 4ZWPA 4U6EA 2GG2A 4IF7A 2GU4A 1YW7A 2GU7A 5CE6A 4U70A 5CIKA 2BWVA 2GTXA 5JI6A 3PKAA 4IKSA 1YW9A 3TB5A 1QZYA 2DFIA 1W2MA 2BHCA 4FLLA 2GZ5A 4IKRA 5CLSA 2Q94A 3MR1A 3L7GA 4HXXA 2EVCA 3CB6A 1C24A 2GGCA 1B59A 1XGOA 1QXZA 4OOKA 2BHBA 4RZYA 2P9AA 1KQ9A 1R5GA 1XGNA 2ADUA 2BH3A 2GG7A 4Z7MA 4IPAA 3S6BA 4U73A 5CDLA 1BN5A 2ZSGA 4S2TP 3CTZA 4ZWOA 1N51A 2GU5A 4PV4A 4EGEA 1C27A 5CDVA 3BIPA 1WL6A 1C22A 2GG9A 3MX6A 4PNCA 1BOAA 4A6WA 4FO7A 4U6JA 1O0XA 2NQ6A 2BWSA 2GA2A 1JAWA 1QXWA 2B3HA 2BWWA 4U6CA 2Q92A 3PKBA 2GGBA 4ZNGA 2V3XA 4ZWUA 2BB7A 3CB5A 4IU6A 3RORA 4FLKA 1YW8A 3FMQA 5D6EA 2GG5A 1M35A 2OAZA 4IKTA 2BHDA 4S2RP 3Q6DA 5E5BA 1XGSA 3PKCA 3RVAA 3IG4A 3BIQA 4QR8A 3D27A 4FKCA 4RGZ1 4FLIA 1YVMA 4IECA 2GG0A 2Q96A 4IDYA 4U69A 5D6FA 1KP0A 2BWUA 3FMRA 1WN1A 4MATA 1C21A 4B28A 2IW2A 1A16A 2MATA 4FUKA 1B6AA 2NQ7A 4U6ZA 2BWTA 1XNZA 4U71A 2OKNA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1W7V A;  5JFR A;  1QXY A;  2V3Y A;  5CNX A;  1R5H A;  1YJ3 A;  2B3L A;  2V3Z A;  5FCF A;  4JUQ A;  2BWX A;  3PKD A;  2B3K A;  4U75 A;  4U6W A;  2BWY A;  5CDE A;  2P98 A;  4R60 A;  5FCH A;  1PV9 A;  1WBQ A;  2Q95 A;  1WL9 A;  3IU8 A;  4S00 A;  2BN7 A;  2HOW A;  4FLJ A;  2GG3 A;  2GU6 A;  2EA4 A;  2EVM A;  2G6P A;  2GG8 A;  3MAT A;  1C23 A;  1R58 A;  2P99 A;  1WLR A;  1KQ0 A;  1WKM A;  1XGM A;  2EVO A;  3FM3 A;  3PKE A;  4IKU A;  1WY2 A;  5JHU A;  3BIT A;  2EA2 A;  2V6C A;  3L24 A;  2Q93 A;  4U76 A;  1Y1N A;  2BHA A;  1CHM A;  1MAT A;  4FO8 A;  4U1B A;  3IU7 A;  4RZZ A;  2Q8K A;  4S01 A;  3TAV A;  4A6V A;  3IU9 A;  4KM3 A;  4ZWP A;  4U6E A;  2GG2 A;  4IF7 A;  2GU4 A;  1YW7 A;  2GU7 A;  5CE6 A;  4U70 A;  5CIK A;  2BWV A;  2GTX A;  5JI6 A;  3PKA A;  4IKS A;  1YW9 A;  3TB5 A;  1QZY A;  2DFI A;  1W2M A;  2BHC A;  4FLL A;  2GZ5 A;  4IKR A;  5CLS A;  2Q94 A;  3MR1 A;  3L7G A;  4HXX A;  2EVC A;  3CB6 A;  1C24 A;  2GGC A;  1B59 A;  1XGO A;  1QXZ A;  4OOK A;  2BHB A;  4RZY A;  2P9A A;  1KQ9 A;  1R5G A;  1XGN A;  2ADU A;  2BH3 A;  2GG7 A;  4Z7M A;  4IPA A;  3S6B A;  4U73 A;  5CDL A;  1BN5 A;  2ZSG A;  4S2T P;  3CTZ A;  4ZWO A;  1N51 A;  2GU5 A;  4PV4 A;  4EGE A;  1C27 A;  5CDV A;  3BIP A;  1WL6 A;  1C22 A;  2GG9 A;  3MX6 A;  4PNC A;  1BOA A;  4A6W A;  4FO7 A;  4U6J A;  1O0X A;  2NQ6 A;  2BWS A;  2GA2 A;  1JAW A;  1QXW A;  2B3H A;  2BWW A;  4U6C A;  2Q92 A;  3PKB A;  2GGB A;  4ZNG A;  2V3X A;  4ZWU A;  2BB7 A;  3CB5 A;  4IU6 A;  3ROR A;  4FLK A;  1YW8 A;  3FMQ A;  5D6E A;  2GG5 A;  1M35 A;  2OAZ A;  4IKT A;  2BHD A;  4S2R P;  3Q6D A;  5E5B A;  1XGS A;  3PKC A;  3RVA A;  3IG4 A;  3BIQ A;  4QR8 A;  3D27 A;  4FKC A;  4RGZ 1;  4FLI A;  1YVM A;  4IEC A;  2GG0 A;  2Q96 A;  4IDY A;  4U69 A;  5D6F A;  1KP0 A;  2BWU A;  3FMR A;  1WN1 A;  4MAT A;  1C21 A;  4B28 A;  2IW2 A;  1A16 A;  2MAT A;  4FUK A;  1B6A A;  2NQ7 A;  4U6Z A;  2BWT A;  1XNZ A;  4U71 A;  2OKN A; 
#chains in the Genus database with same CATH topology
 1W7V A;  5JFR A;  1QXY A;  2V3Y A;  5CNX A;  1R5H A;  1YJ3 A;  2B3L A;  2V3Z A;  5FCF A;  4JUQ A;  2BWX A;  3PKD A;  2B3K A;  4U75 A;  4U6W A;  2BWY A;  5CDE A;  2P98 A;  4R60 A;  5FCH A;  1PV9 A;  1WBQ A;  2Q95 A;  1WL9 A;  3IU8 A;  4S00 A;  2BN7 A;  2HOW A;  4FLJ A;  2GG3 A;  2GU6 A;  2EA4 A;  2EVM A;  2G6P A;  2GG8 A;  3MAT A;  1C23 A;  1R58 A;  2P99 A;  1WLR A;  1KQ0 A;  1WKM A;  1XGM A;  2EVO A;  3FM3 A;  3PKE A;  4IKU A;  1WY2 A;  5JHU A;  3BIT A;  2EA2 A;  2V6C A;  3L24 A;  2Q93 A;  4U76 A;  1Y1N A;  2BHA A;  1CHM A;  1MAT A;  4FO8 A;  4U1B A;  3IU7 A;  4RZZ A;  2Q8K A;  4S01 A;  3TAV A;  4A6V A;  3IU9 A;  4KM3 A;  4ZWP A;  4U6E A;  2GG2 A;  4IF7 A;  2GU4 A;  1YW7 A;  2GU7 A;  5CE6 A;  4U70 A;  5CIK A;  2BWV A;  2GTX A;  5JI6 A;  3PKA A;  4IKS A;  1YW9 A;  3TB5 A;  1QZY A;  2DFI A;  1W2M A;  2BHC A;  4FLL A;  2GZ5 A;  4IKR A;  5CLS A;  2Q94 A;  3MR1 A;  3L7G A;  4HXX A;  2EVC A;  3CB6 A;  1C24 A;  2GGC A;  1B59 A;  1XGO A;  1QXZ A;  4OOK A;  2BHB A;  4RZY A;  2P9A A;  1KQ9 A;  1R5G A;  1XGN A;  2ADU A;  2BH3 A;  2GG7 A;  4Z7M A;  4IPA A;  3S6B A;  4U73 A;  5CDL A;  1BN5 A;  2ZSG A;  4S2T P;  3CTZ A;  4ZWO A;  1N51 A;  2GU5 A;  4PV4 A;  4EGE A;  1C27 A;  5CDV A;  3BIP A;  1WL6 A;  1C22 A;  2GG9 A;  3MX6 A;  4PNC A;  1BOA A;  4A6W A;  4FO7 A;  4U6J A;  1O0X A;  2NQ6 A;  2BWS A;  2GA2 A;  1JAW A;  1QXW A;  2B3H A;  2BWW A;  4U6C A;  2Q92 A;  3PKB A;  2GGB A;  4ZNG A;  2V3X A;  4ZWU A;  2BB7 A;  3CB5 A;  4IU6 A;  3ROR A;  4FLK A;  1YW8 A;  3FMQ A;  5D6E A;  2GG5 A;  1M35 A;  2OAZ A;  4IKT A;  2BHD A;  4S2R P;  3Q6D A;  5E5B A;  1XGS A;  3PKC A;  3RVA A;  3IG4 A;  3BIQ A;  4QR8 A;  3D27 A;  4FKC A;  4RGZ 1;  4FLI A;  1YVM A;  4IEC A;  2GG0 A;  2Q96 A;  4IDY A;  4U69 A;  5D6F A;  1KP0 A;  2BWU A;  3FMR A;  1WN1 A;  4MAT A;  1C21 A;  4B28 A;  2IW2 A;  1A16 A;  2MAT A;  4FUK A;  1B6A A;  2NQ7 A;  4U6Z A;  2BWT A;  1XNZ A;  4U71 A;  2OKN A; 
#chains in the Genus database with same CATH homology
 1W7V A;  5JFR A;  1QXY A;  2V3Y A;  5CNX A;  1R5H A;  1YJ3 A;  2B3L A;  2V3Z A;  5FCF A;  4JUQ A;  2BWX A;  3PKD A;  2B3K A;  4U75 A;  4U6W A;  2BWY A;  5CDE A;  2P98 A;  4R60 A;  5FCH A;  1PV9 A;  1WBQ A;  2Q95 A;  1WL9 A;  3IU8 A;  4S00 A;  2BN7 A;  2HOW A;  4FLJ A;  2GG3 A;  2GU6 A;  2EA4 A;  2EVM A;  2G6P A;  2GG8 A;  3MAT A;  1C23 A;  1R58 A;  2P99 A;  1WLR A;  1KQ0 A;  1WKM A;  1XGM A;  2EVO A;  3FM3 A;  3PKE A;  4IKU A;  1WY2 A;  5JHU A;  3BIT A;  2EA2 A;  2V6C A;  3L24 A;  2Q93 A;  4U76 A;  1Y1N A;  2BHA A;  1CHM A;  1MAT A;  4FO8 A;  4U1B A;  3IU7 A;  4RZZ A;  2Q8K A;  4S01 A;  3TAV A;  4A6V A;  3IU9 A;  4KM3 A;  4ZWP A;  4U6E A;  2GG2 A;  4IF7 A;  2GU4 A;  1YW7 A;  2GU7 A;  5CE6 A;  4U70 A;  5CIK A;  2BWV A;  2GTX A;  5JI6 A;  3PKA A;  4IKS A;  1YW9 A;  3TB5 A;  1QZY A;  2DFI A;  1W2M A;  2BHC A;  4FLL A;  2GZ5 A;  4IKR A;  5CLS A;  2Q94 A;  3MR1 A;  3L7G A;  4HXX A;  2EVC A;  3CB6 A;  1C24 A;  2GGC A;  1B59 A;  1XGO A;  1QXZ A;  4OOK A;  2BHB A;  4RZY A;  2P9A A;  1KQ9 A;  1R5G A;  1XGN A;  2ADU A;  2BH3 A;  2GG7 A;  4Z7M A;  4IPA A;  3S6B A;  4U73 A;  5CDL A;  1BN5 A;  2ZSG A;  4S2T P;  3CTZ A;  4ZWO A;  1N51 A;  2GU5 A;  4PV4 A;  4EGE A;  1C27 A;  5CDV A;  3BIP A;  1WL6 A;  1C22 A;  2GG9 A;  3MX6 A;  4PNC A;  1BOA A;  4A6W A;  4FO7 A;  4U6J A;  1O0X A;  2NQ6 A;  2BWS A;  2GA2 A;  1JAW A;  1QXW A;  2B3H A;  2BWW A;  4U6C A;  2Q92 A;  3PKB A;  2GGB A;  4ZNG A;  2V3X A;  4ZWU A;  2BB7 A;  3CB5 A;  4IU6 A;  3ROR A;  4FLK A;  1YW8 A;  3FMQ A;  5D6E A;  2GG5 A;  1M35 A;  2OAZ A;  4IKT A;  2BHD A;  4S2R P;  3Q6D A;  5E5B A;  1XGS A;  3PKC A;  3RVA A;  3IG4 A;  3BIQ A;  4QR8 A;  3D27 A;  4FKC A;  4RGZ 1;  4FLI A;  1YVM A;  4IEC A;  2GG0 A;  2Q96 A;  4IDY A;  4U69 A;  5D6F A;  1KP0 A;  2BWU A;  3FMR A;  1WN1 A;  4MAT A;  1C21 A;  4B28 A;  2IW2 A;  1A16 A;  2MAT A;  4FUK A;  1B6A A;  2NQ7 A;  4U6Z A;  2BWT A;  1XNZ A;  4U71 A;  2OKN A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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