1C22A

E. coli methionine aminopeptidase: trifluoromethionine complex
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords METHIONINE AMINOPEPTIDASE
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c22A00
4A6WA 2BN7A 1XGOA 1B6AA 3CTZA 2B3HA 4IECA 4B28A 3PKDA 4IKTA 3FMRA 2EA4A 1YW8A 2OKNA 4IF7A 2P98A 3IG4A 5JI6A 2NQ7A 3BITA 4U1BA 1QXYA 2G6PA 2GG8A 2GTXA 1C27A 2V3ZA 1WBQA 5FCFA 4U6CA 5CIKA 5D6FA 2BWXA 3L7GA 2BWYA 2GG9A 4S01A 4HXXA 2ZSGA 5CE6A 5D6EA 4FLLA 2Q96A 4QR8A 4ZNGA 1WL6A 3PKBA 2BWUA 2Q92A 3L24A 4U76A 2BB7A 4U6EA 4RZZA 4OOKA 2EVOA 1PV9A 4S2TP 1XNZA 4S2RP 4IU6A 4IKSA 1XGNA 3TB5A 2P9AA 3IU7A 3Q6DA 2ADUA 2Q93A 4FKCA 2GG7A 2BWTA 1KQ9A 1QXZA 5JHUA 2BHAA 4IPAA 1QZYA 3MX6A 2V3YA 2EA2A 1WY2A 1XGSA 2EVMA 2BWSA 3RORA 3PKEA 1W7VA 2Q95A 1BN5A 4FLJA 2GA2A 4U75A 1WN1A 1R5GA 1B59A 1YJ3A 4U73A 5JFRA 4JUQA 4IDYA 4R60A 2V6CA 2GU4A 2NQ6A 4FUKA 1MATA 1WL9A 2Q94A 1XGMA 3RVAA 4FLKA 3D27A 5CDLA 2GGBA 1C22A 2P99A 3PKCA 3CB6A 2HOWA 1WKMA 1YW7A 3BIQA 1YVMA 4S00A 1A16A 5E5BA 4A6VA 2GU6A 4ZWUA 4U6WA 2V3XA 4FO8A 4U6ZA 4PNCA 2MATA 4U70A 1QXWA 1KQ0A 4ZWOA 2Q8KA 2OAZA 2BWWA 4MATA 2B3KA 2GZ5A 1C23A 3BIPA 2EVCA 4U69A 4EGEA 2BWVA 2GU7A 1R5HA 3FMQA 4IKUA 4Z7MA 2GG2A 4PV4A 1BOAA 4KM3A 3IU8A 1CHMA 1W2MA 1M35A 2GU5A 4ZWPA 1WLRA 5CLSA 1JAWA 1N51A 2DFIA 2GG3A 1C24A 5CNXA 1O0XA 1R58A 2BHDA 3FM3A 3PKAA 2B3LA 1C21A 1KP0A 5CDEA 1Y1NA 4RZYA 5CDVA 4U71A 2IW2A 4FO7A 3S6BA 2GG0A 4IKRA 3TAVA 2GGCA 4FLIA 4RGZ1 2BHCA 2BH3A 3CB5A 4U6JA 3MATA 2GG5A 3IU9A 2BHBA 3MR1A 1YW9A 5FCHA
chains in the Genus database with same CATH superfamily
4A6WA 2BN7A 1XGOA 1B6AA 3CTZA 2B3HA 4IECA 4B28A 3PKDA 4IKTA 3FMRA 2EA4A 1YW8A 2OKNA 4IF7A 2P98A 3IG4A 5JI6A 2NQ7A 3BITA 4U1BA 1QXYA 2G6PA 2GG8A 2GTXA 1C27A 2V3ZA 1WBQA 5FCFA 4U6CA 5CIKA 5D6FA 2BWXA 3L7GA 2BWYA 2GG9A 4S01A 4HXXA 2ZSGA 5CE6A 5D6EA 4FLLA 2Q96A 4QR8A 4ZNGA 1WL6A 3PKBA 2BWUA 2Q92A 3L24A 4U76A 2BB7A 4U6EA 4RZZA 4OOKA 2EVOA 1PV9A 4S2TP 1XNZA 4S2RP 4IU6A 4IKSA 1XGNA 3TB5A 2P9AA 3IU7A 3Q6DA 2ADUA 2Q93A 4FKCA 2GG7A 2BWTA 1KQ9A 1QXZA 5JHUA 2BHAA 4IPAA 1QZYA 3MX6A 2V3YA 2EA2A 1WY2A 1XGSA 2EVMA 2BWSA 3RORA 3PKEA 1W7VA 2Q95A 1BN5A 4FLJA 2GA2A 4U75A 1WN1A 1R5GA 1B59A 1YJ3A 4U73A 5JFRA 4JUQA 4IDYA 4R60A 2V6CA 2GU4A 2NQ6A 4FUKA 1MATA 1WL9A 2Q94A 1XGMA 3RVAA 4FLKA 3D27A 5CDLA 2GGBA 1C22A 2P99A 3PKCA 3CB6A 2HOWA 1WKMA 1YW7A 3BIQA 1YVMA 4S00A 1A16A 5E5BA 4A6VA 2GU6A 4ZWUA 4U6WA 2V3XA 4FO8A 4U6ZA 4PNCA 2MATA 4U70A 1QXWA 1KQ0A 4ZWOA 2Q8KA 2OAZA 2BWWA 4MATA 2B3KA 2GZ5A 1C23A 3BIPA 2EVCA 4U69A 4EGEA 2BWVA 2GU7A 1R5HA 3FMQA 4IKUA 4Z7MA 2GG2A 4PV4A 1BOAA 4KM3A 3IU8A 1CHMA 1W2MA 1M35A 2GU5A 4ZWPA 1WLRA 5CLSA 1JAWA 1N51A 2DFIA 2GG3A 1C24A 5CNXA 1O0XA 1R58A 2BHDA 3FM3A 3PKAA 2B3LA 1C21A 1KP0A 5CDEA 1Y1NA 4RZYA 5CDVA 4U71A 2IW2A 4FO7A 3S6BA 2GG0A 4IKRA 3TAVA 2GGCA 4FLIA 4RGZ1 2BHCA 2BH3A 3CB5A 4U6JA 3MATA 2GG5A 3IU9A 2BHBA 3MR1A 1YW9A 5FCHA
chains in the Genus database with same CATH topology
4A6WA 2BN7A 1XGOA 1B6AA 3CTZA 2B3HA 4IECA 4B28A 3PKDA 4IKTA 3FMRA 2EA4A 1YW8A 2OKNA 4IF7A 2P98A 3IG4A 5JI6A 2NQ7A 3BITA 4U1BA 1QXYA 2G6PA 2GG8A 2GTXA 1C27A 2V3ZA 1WBQA 5FCFA 4U6CA 5CIKA 5D6FA 2BWXA 3L7GA 2BWYA 2GG9A 4S01A 4HXXA 2ZSGA 5CE6A 5D6EA 4FLLA 2Q96A 4QR8A 4ZNGA 1WL6A 3PKBA 2BWUA 2Q92A 3L24A 4U76A 2BB7A 4U6EA 4RZZA 4OOKA 2EVOA 1PV9A 4S2TP 1XNZA 4S2RP 4IU6A 4IKSA 1XGNA 3TB5A 2P9AA 3IU7A 3Q6DA 2ADUA 2Q93A 4FKCA 2GG7A 2BWTA 1KQ9A 1QXZA 5JHUA 2BHAA 4IPAA 1QZYA 3MX6A 2V3YA 2EA2A 1WY2A 1XGSA 2EVMA 2BWSA 3RORA 3PKEA 1W7VA 2Q95A 1BN5A 4FLJA 2GA2A 4U75A 1WN1A 1R5GA 1B59A 1YJ3A 4U73A 5JFRA 4JUQA 4IDYA 4R60A 2V6CA 2GU4A 2NQ6A 4FUKA 1MATA 1WL9A 2Q94A 1XGMA 3RVAA 4FLKA 3D27A 5CDLA 2GGBA 1C22A 2P99A 3PKCA 3CB6A 2HOWA 1WKMA 1YW7A 3BIQA 1YVMA 4S00A 1A16A 5E5BA 4A6VA 2GU6A 4ZWUA 4U6WA 2V3XA 4FO8A 4U6ZA 4PNCA 2MATA 4U70A 1QXWA 1KQ0A 4ZWOA 2Q8KA 2OAZA 2BWWA 4MATA 2B3KA 2GZ5A 1C23A 3BIPA 2EVCA 4U69A 4EGEA 2BWVA 2GU7A 1R5HA 3FMQA 4IKUA 4Z7MA 2GG2A 4PV4A 1BOAA 4KM3A 3IU8A 1CHMA 1W2MA 1M35A 2GU5A 4ZWPA 1WLRA 5CLSA 1JAWA 1N51A 2DFIA 2GG3A 1C24A 5CNXA 1O0XA 1R58A 2BHDA 3FM3A 3PKAA 2B3LA 1C21A 1KP0A 5CDEA 1Y1NA 4RZYA 5CDVA 4U71A 2IW2A 4FO7A 3S6BA 2GG0A 4IKRA 3TAVA 2GGCA 4FLIA 4RGZ1 2BHCA 2BH3A 3CB5A 4U6JA 3MATA 2GG5A 3IU9A 2BHBA 3MR1A 1YW9A 5FCHA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A6W A;  2BN7 A;  1XGO A;  1B6A A;  3CTZ A;  2B3H A;  4IEC A;  4B28 A;  3PKD A;  4IKT A;  3FMR A;  2EA4 A;  1YW8 A;  2OKN A;  4IF7 A;  2P98 A;  3IG4 A;  5JI6 A;  2NQ7 A;  3BIT A;  4U1B A;  1QXY A;  2G6P A;  2GG8 A;  2GTX A;  1C27 A;  2V3Z A;  1WBQ A;  5FCF A;  4U6C A;  5CIK A;  5D6F A;  2BWX A;  3L7G A;  2BWY A;  2GG9 A;  4S01 A;  4HXX A;  2ZSG A;  5CE6 A;  5D6E A;  4FLL A;  2Q96 A;  4QR8 A;  4ZNG A;  1WL6 A;  3PKB A;  2BWU A;  2Q92 A;  3L24 A;  4U76 A;  2BB7 A;  4U6E A;  4RZZ A;  4OOK A;  2EVO A;  1PV9 A;  4S2T P;  1XNZ A;  4S2R P;  4IU6 A;  4IKS A;  1XGN A;  3TB5 A;  2P9A A;  3IU7 A;  3Q6D A;  2ADU A;  2Q93 A;  4FKC A;  2GG7 A;  2BWT A;  1KQ9 A;  1QXZ A;  5JHU A;  2BHA A;  4IPA A;  1QZY A;  3MX6 A;  2V3Y A;  2EA2 A;  1WY2 A;  1XGS A;  2EVM A;  2BWS A;  3ROR A;  3PKE A;  1W7V A;  2Q95 A;  1BN5 A;  4FLJ A;  2GA2 A;  4U75 A;  1WN1 A;  1R5G A;  1B59 A;  1YJ3 A;  4U73 A;  5JFR A;  4JUQ A;  4IDY A;  4R60 A;  2V6C A;  2GU4 A;  2NQ6 A;  4FUK A;  1MAT A;  1WL9 A;  2Q94 A;  1XGM A;  3RVA A;  4FLK A;  3D27 A;  5CDL A;  2GGB A;  1C22 A;  2P99 A;  3PKC A;  3CB6 A;  2HOW A;  1WKM A;  1YW7 A;  3BIQ A;  1YVM A;  4S00 A;  1A16 A;  5E5B A;  4A6V A;  2GU6 A;  4ZWU A;  4U6W A;  2V3X A;  4FO8 A;  4U6Z A;  4PNC A;  2MAT A;  4U70 A;  1QXW A;  1KQ0 A;  4ZWO A;  2Q8K A;  2OAZ A;  2BWW A;  4MAT A;  2B3K A;  2GZ5 A;  1C23 A;  3BIP A;  2EVC A;  4U69 A;  4EGE A;  2BWV A;  2GU7 A;  1R5H A;  3FMQ A;  4IKU A;  4Z7M A;  2GG2 A;  4PV4 A;  1BOA A;  4KM3 A;  3IU8 A;  1CHM A;  1W2M A;  1M35 A;  2GU5 A;  4ZWP A;  1WLR A;  5CLS A;  1JAW A;  1N51 A;  2DFI A;  2GG3 A;  1C24 A;  5CNX A;  1O0X A;  1R58 A;  2BHD A;  3FM3 A;  3PKA A;  2B3L A;  1C21 A;  1KP0 A;  5CDE A;  1Y1N A;  4RZY A;  5CDV A;  4U71 A;  2IW2 A;  4FO7 A;  3S6B A;  2GG0 A;  4IKR A;  3TAV A;  2GGC A;  4FLI A;  4RGZ 1;  2BHC A;  2BH3 A;  3CB5 A;  4U6J A;  3MAT A;  2GG5 A;  3IU9 A;  2BHB A;  3MR1 A;  1YW9 A;  5FCH A; 
#chains in the Genus database with same CATH topology
 4A6W A;  2BN7 A;  1XGO A;  1B6A A;  3CTZ A;  2B3H A;  4IEC A;  4B28 A;  3PKD A;  4IKT A;  3FMR A;  2EA4 A;  1YW8 A;  2OKN A;  4IF7 A;  2P98 A;  3IG4 A;  5JI6 A;  2NQ7 A;  3BIT A;  4U1B A;  1QXY A;  2G6P A;  2GG8 A;  2GTX A;  1C27 A;  2V3Z A;  1WBQ A;  5FCF A;  4U6C A;  5CIK A;  5D6F A;  2BWX A;  3L7G A;  2BWY A;  2GG9 A;  4S01 A;  4HXX A;  2ZSG A;  5CE6 A;  5D6E A;  4FLL A;  2Q96 A;  4QR8 A;  4ZNG A;  1WL6 A;  3PKB A;  2BWU A;  2Q92 A;  3L24 A;  4U76 A;  2BB7 A;  4U6E A;  4RZZ A;  4OOK A;  2EVO A;  1PV9 A;  4S2T P;  1XNZ A;  4S2R P;  4IU6 A;  4IKS A;  1XGN A;  3TB5 A;  2P9A A;  3IU7 A;  3Q6D A;  2ADU A;  2Q93 A;  4FKC A;  2GG7 A;  2BWT A;  1KQ9 A;  1QXZ A;  5JHU A;  2BHA A;  4IPA A;  1QZY A;  3MX6 A;  2V3Y A;  2EA2 A;  1WY2 A;  1XGS A;  2EVM A;  2BWS A;  3ROR A;  3PKE A;  1W7V A;  2Q95 A;  1BN5 A;  4FLJ A;  2GA2 A;  4U75 A;  1WN1 A;  1R5G A;  1B59 A;  1YJ3 A;  4U73 A;  5JFR A;  4JUQ A;  4IDY A;  4R60 A;  2V6C A;  2GU4 A;  2NQ6 A;  4FUK A;  1MAT A;  1WL9 A;  2Q94 A;  1XGM A;  3RVA A;  4FLK A;  3D27 A;  5CDL A;  2GGB A;  1C22 A;  2P99 A;  3PKC A;  3CB6 A;  2HOW A;  1WKM A;  1YW7 A;  3BIQ A;  1YVM A;  4S00 A;  1A16 A;  5E5B A;  4A6V A;  2GU6 A;  4ZWU A;  4U6W A;  2V3X A;  4FO8 A;  4U6Z A;  4PNC A;  2MAT A;  4U70 A;  1QXW A;  1KQ0 A;  4ZWO A;  2Q8K A;  2OAZ A;  2BWW A;  4MAT A;  2B3K A;  2GZ5 A;  1C23 A;  3BIP A;  2EVC A;  4U69 A;  4EGE A;  2BWV A;  2GU7 A;  1R5H A;  3FMQ A;  4IKU A;  4Z7M A;  2GG2 A;  4PV4 A;  1BOA A;  4KM3 A;  3IU8 A;  1CHM A;  1W2M A;  1M35 A;  2GU5 A;  4ZWP A;  1WLR A;  5CLS A;  1JAW A;  1N51 A;  2DFI A;  2GG3 A;  1C24 A;  5CNX A;  1O0X A;  1R58 A;  2BHD A;  3FM3 A;  3PKA A;  2B3L A;  1C21 A;  1KP0 A;  5CDE A;  1Y1N A;  4RZY A;  5CDV A;  4U71 A;  2IW2 A;  4FO7 A;  3S6B A;  2GG0 A;  4IKR A;  3TAV A;  2GGC A;  4FLI A;  4RGZ 1;  2BHC A;  2BH3 A;  3CB5 A;  4U6J A;  3MAT A;  2GG5 A;  3IU9 A;  2BHB A;  3MR1 A;  1YW9 A;  5FCH A; 
#chains in the Genus database with same CATH homology
 4A6W A;  2BN7 A;  1XGO A;  1B6A A;  3CTZ A;  2B3H A;  4IEC A;  4B28 A;  3PKD A;  4IKT A;  3FMR A;  2EA4 A;  1YW8 A;  2OKN A;  4IF7 A;  2P98 A;  3IG4 A;  5JI6 A;  2NQ7 A;  3BIT A;  4U1B A;  1QXY A;  2G6P A;  2GG8 A;  2GTX A;  1C27 A;  2V3Z A;  1WBQ A;  5FCF A;  4U6C A;  5CIK A;  5D6F A;  2BWX A;  3L7G A;  2BWY A;  2GG9 A;  4S01 A;  4HXX A;  2ZSG A;  5CE6 A;  5D6E A;  4FLL A;  2Q96 A;  4QR8 A;  4ZNG A;  1WL6 A;  3PKB A;  2BWU A;  2Q92 A;  3L24 A;  4U76 A;  2BB7 A;  4U6E A;  4RZZ A;  4OOK A;  2EVO A;  1PV9 A;  4S2T P;  1XNZ A;  4S2R P;  4IU6 A;  4IKS A;  1XGN A;  3TB5 A;  2P9A A;  3IU7 A;  3Q6D A;  2ADU A;  2Q93 A;  4FKC A;  2GG7 A;  2BWT A;  1KQ9 A;  1QXZ A;  5JHU A;  2BHA A;  4IPA A;  1QZY A;  3MX6 A;  2V3Y A;  2EA2 A;  1WY2 A;  1XGS A;  2EVM A;  2BWS A;  3ROR A;  3PKE A;  1W7V A;  2Q95 A;  1BN5 A;  4FLJ A;  2GA2 A;  4U75 A;  1WN1 A;  1R5G A;  1B59 A;  1YJ3 A;  4U73 A;  5JFR A;  4JUQ A;  4IDY A;  4R60 A;  2V6C A;  2GU4 A;  2NQ6 A;  4FUK A;  1MAT A;  1WL9 A;  2Q94 A;  1XGM A;  3RVA A;  4FLK A;  3D27 A;  5CDL A;  2GGB A;  1C22 A;  2P99 A;  3PKC A;  3CB6 A;  2HOW A;  1WKM A;  1YW7 A;  3BIQ A;  1YVM A;  4S00 A;  1A16 A;  5E5B A;  4A6V A;  2GU6 A;  4ZWU A;  4U6W A;  2V3X A;  4FO8 A;  4U6Z A;  4PNC A;  2MAT A;  4U70 A;  1QXW A;  1KQ0 A;  4ZWO A;  2Q8K A;  2OAZ A;  2BWW A;  4MAT A;  2B3K A;  2GZ5 A;  1C23 A;  3BIP A;  2EVC A;  4U69 A;  4EGE A;  2BWV A;  2GU7 A;  1R5H A;  3FMQ A;  4IKU A;  4Z7M A;  2GG2 A;  4PV4 A;  1BOA A;  4KM3 A;  3IU8 A;  1CHM A;  1W2M A;  1M35 A;  2GU5 A;  4ZWP A;  1WLR A;  5CLS A;  1JAW A;  1N51 A;  2DFI A;  2GG3 A;  1C24 A;  5CNX A;  1O0X A;  1R58 A;  2BHD A;  3FM3 A;  3PKA A;  2B3L A;  1C21 A;  1KP0 A;  5CDE A;  1Y1N A;  4RZY A;  5CDV A;  4U71 A;  2IW2 A;  4FO7 A;  3S6B A;  2GG0 A;  4IKR A;  3TAV A;  2GGC A;  4FLI A;  4RGZ 1;  2BHC A;  2BH3 A;  3CB5 A;  4U6J A;  3MAT A;  2GG5 A;  3IU9 A;  2BHB A;  3MR1 A;  1YW9 A;  5FCH A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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