1C22A

E. coli methionine aminopeptidase: trifluoromethionine complex
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords METHIONINE AMINOPEPTIDASE
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c22A00
4ZNGA 2GU7A 2BB7A 4S00A 1CHMA 4ZWUA 4U6EA 2GG8A 2BWYA 3TB5A 1YJ3A 4FO7A 4KM3A 4U6JA 1O0XA 4A6VA 4FLIA 2GZ5A 2P99A 4IU6A 2BHCA 4ZWOA 1WKMA 1R58A 2OKNA 3IU9A 2GGCA 2BHDA 1KQ0A 3L7GA 1C24A 1KP0A 1QZYA 3PKBA 4QR8A 4B28A 5CDVA 3IG4A 2IW2A 2NQ7A 3IU7A 2BWSA 4MATA 2B3LA 1C22A 2GGBA 4U73A 2GG7A 3D27A 3CB6A 3BIPA 4U6WA 1R5HA 2OAZA 3PKAA 4U1BA 3S6BA 1R5GA 2NQ6A 2EVOA 2GG5A 4S2TP 4PV4A 2P9AA 1XGMA 2Q8KA 1KQ9A 1BOAA 1WL9A 2B3HA 3FM3A 4S01A 3MR1A 5D6EA 2ADUA 1XGNA 3PKEA 1PV9A 1M35A 1MATA 4IKRA 1XNZA 1WBQA 1XGSA 4FO8A 4U71A 1WN1A 1YVMA 4IECA 4R60A 2Q95A 2V3ZA 4HXXA 3MATA 2BHAA 3FMQA 2GU5A 2Q96A 2V6CA 4FUKA 5JFRA 5JHUA 4S2RP 2GA2A 4U6ZA 1QXZA 1W7VA 2GG0A 5JI6A 2Q92A 4IF7A 4U6CA 4PNCA 4RZZA 3L24A 5E5BA 2B3KA 5CDLA 2DFIA 4JUQA 2BN7A 2EVMA 1C23A 4U76A 3IU8A 4FLLA 4OOKA 1WLRA 2MATA 4A6WA 2V3YA 4FKCA 5CNXA 5CDEA 3PKCA 5CE6A 1YW8A 4IDYA 2GU4A 4IKUA 2EA2A 4IKTA 1JAWA 2V3XA 4FLKA 5CIKA 5D6FA 2BWUA 4ZWPA 2GG9A 2G6PA 4IPAA 4EGEA 3BIQA 2GU6A 3PKDA 1WY2A 1BN5A 2GG2A 2Q93A 3CB5A 2EA4A 3Q6DA 1QXYA 5FCHA 4RZYA 1C21A 1N51A 2BHBA 1Y1NA 1QXWA 4U75A 2BH3A 2BWTA 4IKSA 2EVCA 4U70A 4RGZ1 4U69A 1B59A 3FMRA 3RORA 2GTXA 2Q94A 5CLSA 1W2MA 2BWVA 4FLJA 3CTZA 3MX6A 3BITA 1WL6A 2GG3A 5FCFA 1YW9A 1YW7A 2BWXA 2HOWA 2P98A 1B6AA 1C27A 2ZSGA 3TAVA 3RVAA 4Z7MA 1XGOA 1A16A 2BWWA
chains in the Genus database with same CATH superfamily
4ZNGA 2GU7A 2BB7A 4S00A 1CHMA 4ZWUA 4U6EA 2GG8A 2BWYA 3TB5A 1YJ3A 4FO7A 4KM3A 4U6JA 1O0XA 4A6VA 4FLIA 2GZ5A 2P99A 4IU6A 2BHCA 4ZWOA 1WKMA 1R58A 2OKNA 3IU9A 2GGCA 2BHDA 1KQ0A 3L7GA 1C24A 1KP0A 1QZYA 3PKBA 4QR8A 4B28A 5CDVA 3IG4A 2IW2A 2NQ7A 3IU7A 2BWSA 4MATA 2B3LA 1C22A 2GGBA 4U73A 2GG7A 3D27A 3CB6A 3BIPA 4U6WA 1R5HA 2OAZA 3PKAA 4U1BA 3S6BA 1R5GA 2NQ6A 2EVOA 2GG5A 4S2TP 4PV4A 2P9AA 1XGMA 2Q8KA 1KQ9A 1BOAA 1WL9A 2B3HA 3FM3A 4S01A 3MR1A 5D6EA 2ADUA 1XGNA 3PKEA 1PV9A 1M35A 1MATA 4IKRA 1XNZA 1WBQA 1XGSA 4FO8A 4U71A 1WN1A 1YVMA 4IECA 4R60A 2Q95A 2V3ZA 4HXXA 3MATA 2BHAA 3FMQA 2GU5A 2Q96A 2V6CA 4FUKA 5JFRA 5JHUA 4S2RP 2GA2A 4U6ZA 1QXZA 1W7VA 2GG0A 5JI6A 2Q92A 4IF7A 4U6CA 4PNCA 4RZZA 3L24A 5E5BA 2B3KA 5CDLA 2DFIA 4JUQA 2BN7A 2EVMA 1C23A 4U76A 3IU8A 4FLLA 4OOKA 1WLRA 2MATA 4A6WA 2V3YA 4FKCA 5CNXA 5CDEA 3PKCA 5CE6A 1YW8A 4IDYA 2GU4A 4IKUA 2EA2A 4IKTA 1JAWA 2V3XA 4FLKA 5CIKA 5D6FA 2BWUA 4ZWPA 2GG9A 2G6PA 4IPAA 4EGEA 3BIQA 2GU6A 3PKDA 1WY2A 1BN5A 2GG2A 2Q93A 3CB5A 2EA4A 3Q6DA 1QXYA 5FCHA 4RZYA 1C21A 1N51A 2BHBA 1Y1NA 1QXWA 4U75A 2BH3A 2BWTA 4IKSA 2EVCA 4U70A 4RGZ1 4U69A 1B59A 3FMRA 3RORA 2GTXA 2Q94A 5CLSA 1W2MA 2BWVA 4FLJA 3CTZA 3MX6A 3BITA 1WL6A 2GG3A 5FCFA 1YW9A 1YW7A 2BWXA 2HOWA 2P98A 1B6AA 1C27A 2ZSGA 3TAVA 3RVAA 4Z7MA 1XGOA 1A16A 2BWWA
chains in the Genus database with same CATH topology
4ZNGA 2GU7A 2BB7A 4S00A 1CHMA 4ZWUA 4U6EA 2GG8A 2BWYA 3TB5A 1YJ3A 4FO7A 4KM3A 4U6JA 1O0XA 4A6VA 4FLIA 2GZ5A 2P99A 4IU6A 2BHCA 4ZWOA 1WKMA 1R58A 2OKNA 3IU9A 2GGCA 2BHDA 1KQ0A 3L7GA 1C24A 1KP0A 1QZYA 3PKBA 4QR8A 4B28A 5CDVA 3IG4A 2IW2A 2NQ7A 3IU7A 2BWSA 4MATA 2B3LA 1C22A 2GGBA 4U73A 2GG7A 3D27A 3CB6A 3BIPA 4U6WA 1R5HA 2OAZA 3PKAA 4U1BA 3S6BA 1R5GA 2NQ6A 2EVOA 2GG5A 4S2TP 4PV4A 2P9AA 1XGMA 2Q8KA 1KQ9A 1BOAA 1WL9A 2B3HA 3FM3A 4S01A 3MR1A 5D6EA 2ADUA 1XGNA 3PKEA 1PV9A 1M35A 1MATA 4IKRA 1XNZA 1WBQA 1XGSA 4FO8A 4U71A 1WN1A 1YVMA 4IECA 4R60A 2Q95A 2V3ZA 4HXXA 3MATA 2BHAA 3FMQA 2GU5A 2Q96A 2V6CA 4FUKA 5JFRA 5JHUA 4S2RP 2GA2A 4U6ZA 1QXZA 1W7VA 2GG0A 5JI6A 2Q92A 4IF7A 4U6CA 4PNCA 4RZZA 3L24A 5E5BA 2B3KA 5CDLA 2DFIA 4JUQA 2BN7A 2EVMA 1C23A 4U76A 3IU8A 4FLLA 4OOKA 1WLRA 2MATA 4A6WA 2V3YA 4FKCA 5CNXA 5CDEA 3PKCA 5CE6A 1YW8A 4IDYA 2GU4A 4IKUA 2EA2A 4IKTA 1JAWA 2V3XA 4FLKA 5CIKA 5D6FA 2BWUA 4ZWPA 2GG9A 2G6PA 4IPAA 4EGEA 3BIQA 2GU6A 3PKDA 1WY2A 1BN5A 2GG2A 2Q93A 3CB5A 2EA4A 3Q6DA 1QXYA 5FCHA 4RZYA 1C21A 1N51A 2BHBA 1Y1NA 1QXWA 4U75A 2BH3A 2BWTA 4IKSA 2EVCA 4U70A 4RGZ1 4U69A 1B59A 3FMRA 3RORA 2GTXA 2Q94A 5CLSA 1W2MA 2BWVA 4FLJA 3CTZA 3MX6A 3BITA 1WL6A 2GG3A 5FCFA 1YW9A 1YW7A 2BWXA 2HOWA 2P98A 1B6AA 1C27A 2ZSGA 3TAVA 3RVAA 4Z7MA 1XGOA 1A16A 2BWWA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4ZNG A;  2GU7 A;  2BB7 A;  4S00 A;  1CHM A;  4ZWU A;  4U6E A;  2GG8 A;  2BWY A;  3TB5 A;  1YJ3 A;  4FO7 A;  4KM3 A;  4U6J A;  1O0X A;  4A6V A;  4FLI A;  2GZ5 A;  2P99 A;  4IU6 A;  2BHC A;  4ZWO A;  1WKM A;  1R58 A;  2OKN A;  3IU9 A;  2GGC A;  2BHD A;  1KQ0 A;  3L7G A;  1C24 A;  1KP0 A;  1QZY A;  3PKB A;  4QR8 A;  4B28 A;  5CDV A;  3IG4 A;  2IW2 A;  2NQ7 A;  3IU7 A;  2BWS A;  4MAT A;  2B3L A;  1C22 A;  2GGB A;  4U73 A;  2GG7 A;  3D27 A;  3CB6 A;  3BIP A;  4U6W A;  1R5H A;  2OAZ A;  3PKA A;  4U1B A;  3S6B A;  1R5G A;  2NQ6 A;  2EVO A;  2GG5 A;  4S2T P;  4PV4 A;  2P9A A;  1XGM A;  2Q8K A;  1KQ9 A;  1BOA A;  1WL9 A;  2B3H A;  3FM3 A;  4S01 A;  3MR1 A;  5D6E A;  2ADU A;  1XGN A;  3PKE A;  1PV9 A;  1M35 A;  1MAT A;  4IKR A;  1XNZ A;  1WBQ A;  1XGS A;  4FO8 A;  4U71 A;  1WN1 A;  1YVM A;  4IEC A;  4R60 A;  2Q95 A;  2V3Z A;  4HXX A;  3MAT A;  2BHA A;  3FMQ A;  2GU5 A;  2Q96 A;  2V6C A;  4FUK A;  5JFR A;  5JHU A;  4S2R P;  2GA2 A;  4U6Z A;  1QXZ A;  1W7V A;  2GG0 A;  5JI6 A;  2Q92 A;  4IF7 A;  4U6C A;  4PNC A;  4RZZ A;  3L24 A;  5E5B A;  2B3K A;  5CDL A;  2DFI A;  4JUQ A;  2BN7 A;  2EVM A;  1C23 A;  4U76 A;  3IU8 A;  4FLL A;  4OOK A;  1WLR A;  2MAT A;  4A6W A;  2V3Y A;  4FKC A;  5CNX A;  5CDE A;  3PKC A;  5CE6 A;  1YW8 A;  4IDY A;  2GU4 A;  4IKU A;  2EA2 A;  4IKT A;  1JAW A;  2V3X A;  4FLK A;  5CIK A;  5D6F A;  2BWU A;  4ZWP A;  2GG9 A;  2G6P A;  4IPA A;  4EGE A;  3BIQ A;  2GU6 A;  3PKD A;  1WY2 A;  1BN5 A;  2GG2 A;  2Q93 A;  3CB5 A;  2EA4 A;  3Q6D A;  1QXY A;  5FCH A;  4RZY A;  1C21 A;  1N51 A;  2BHB A;  1Y1N A;  1QXW A;  4U75 A;  2BH3 A;  2BWT A;  4IKS A;  2EVC A;  4U70 A;  4RGZ 1;  4U69 A;  1B59 A;  3FMR A;  3ROR A;  2GTX A;  2Q94 A;  5CLS A;  1W2M A;  2BWV A;  4FLJ A;  3CTZ A;  3MX6 A;  3BIT A;  1WL6 A;  2GG3 A;  5FCF A;  1YW9 A;  1YW7 A;  2BWX A;  2HOW A;  2P98 A;  1B6A A;  1C27 A;  2ZSG A;  3TAV A;  3RVA A;  4Z7M A;  1XGO A;  1A16 A;  2BWW A; 
#chains in the Genus database with same CATH topology
 4ZNG A;  2GU7 A;  2BB7 A;  4S00 A;  1CHM A;  4ZWU A;  4U6E A;  2GG8 A;  2BWY A;  3TB5 A;  1YJ3 A;  4FO7 A;  4KM3 A;  4U6J A;  1O0X A;  4A6V A;  4FLI A;  2GZ5 A;  2P99 A;  4IU6 A;  2BHC A;  4ZWO A;  1WKM A;  1R58 A;  2OKN A;  3IU9 A;  2GGC A;  2BHD A;  1KQ0 A;  3L7G A;  1C24 A;  1KP0 A;  1QZY A;  3PKB A;  4QR8 A;  4B28 A;  5CDV A;  3IG4 A;  2IW2 A;  2NQ7 A;  3IU7 A;  2BWS A;  4MAT A;  2B3L A;  1C22 A;  2GGB A;  4U73 A;  2GG7 A;  3D27 A;  3CB6 A;  3BIP A;  4U6W A;  1R5H A;  2OAZ A;  3PKA A;  4U1B A;  3S6B A;  1R5G A;  2NQ6 A;  2EVO A;  2GG5 A;  4S2T P;  4PV4 A;  2P9A A;  1XGM A;  2Q8K A;  1KQ9 A;  1BOA A;  1WL9 A;  2B3H A;  3FM3 A;  4S01 A;  3MR1 A;  5D6E A;  2ADU A;  1XGN A;  3PKE A;  1PV9 A;  1M35 A;  1MAT A;  4IKR A;  1XNZ A;  1WBQ A;  1XGS A;  4FO8 A;  4U71 A;  1WN1 A;  1YVM A;  4IEC A;  4R60 A;  2Q95 A;  2V3Z A;  4HXX A;  3MAT A;  2BHA A;  3FMQ A;  2GU5 A;  2Q96 A;  2V6C A;  4FUK A;  5JFR A;  5JHU A;  4S2R P;  2GA2 A;  4U6Z A;  1QXZ A;  1W7V A;  2GG0 A;  5JI6 A;  2Q92 A;  4IF7 A;  4U6C A;  4PNC A;  4RZZ A;  3L24 A;  5E5B A;  2B3K A;  5CDL A;  2DFI A;  4JUQ A;  2BN7 A;  2EVM A;  1C23 A;  4U76 A;  3IU8 A;  4FLL A;  4OOK A;  1WLR A;  2MAT A;  4A6W A;  2V3Y A;  4FKC A;  5CNX A;  5CDE A;  3PKC A;  5CE6 A;  1YW8 A;  4IDY A;  2GU4 A;  4IKU A;  2EA2 A;  4IKT A;  1JAW A;  2V3X A;  4FLK A;  5CIK A;  5D6F A;  2BWU A;  4ZWP A;  2GG9 A;  2G6P A;  4IPA A;  4EGE A;  3BIQ A;  2GU6 A;  3PKD A;  1WY2 A;  1BN5 A;  2GG2 A;  2Q93 A;  3CB5 A;  2EA4 A;  3Q6D A;  1QXY A;  5FCH A;  4RZY A;  1C21 A;  1N51 A;  2BHB A;  1Y1N A;  1QXW A;  4U75 A;  2BH3 A;  2BWT A;  4IKS A;  2EVC A;  4U70 A;  4RGZ 1;  4U69 A;  1B59 A;  3FMR A;  3ROR A;  2GTX A;  2Q94 A;  5CLS A;  1W2M A;  2BWV A;  4FLJ A;  3CTZ A;  3MX6 A;  3BIT A;  1WL6 A;  2GG3 A;  5FCF A;  1YW9 A;  1YW7 A;  2BWX A;  2HOW A;  2P98 A;  1B6A A;  1C27 A;  2ZSG A;  3TAV A;  3RVA A;  4Z7M A;  1XGO A;  1A16 A;  2BWW A; 
#chains in the Genus database with same CATH homology
 4ZNG A;  2GU7 A;  2BB7 A;  4S00 A;  1CHM A;  4ZWU A;  4U6E A;  2GG8 A;  2BWY A;  3TB5 A;  1YJ3 A;  4FO7 A;  4KM3 A;  4U6J A;  1O0X A;  4A6V A;  4FLI A;  2GZ5 A;  2P99 A;  4IU6 A;  2BHC A;  4ZWO A;  1WKM A;  1R58 A;  2OKN A;  3IU9 A;  2GGC A;  2BHD A;  1KQ0 A;  3L7G A;  1C24 A;  1KP0 A;  1QZY A;  3PKB A;  4QR8 A;  4B28 A;  5CDV A;  3IG4 A;  2IW2 A;  2NQ7 A;  3IU7 A;  2BWS A;  4MAT A;  2B3L A;  1C22 A;  2GGB A;  4U73 A;  2GG7 A;  3D27 A;  3CB6 A;  3BIP A;  4U6W A;  1R5H A;  2OAZ A;  3PKA A;  4U1B A;  3S6B A;  1R5G A;  2NQ6 A;  2EVO A;  2GG5 A;  4S2T P;  4PV4 A;  2P9A A;  1XGM A;  2Q8K A;  1KQ9 A;  1BOA A;  1WL9 A;  2B3H A;  3FM3 A;  4S01 A;  3MR1 A;  5D6E A;  2ADU A;  1XGN A;  3PKE A;  1PV9 A;  1M35 A;  1MAT A;  4IKR A;  1XNZ A;  1WBQ A;  1XGS A;  4FO8 A;  4U71 A;  1WN1 A;  1YVM A;  4IEC A;  4R60 A;  2Q95 A;  2V3Z A;  4HXX A;  3MAT A;  2BHA A;  3FMQ A;  2GU5 A;  2Q96 A;  2V6C A;  4FUK A;  5JFR A;  5JHU A;  4S2R P;  2GA2 A;  4U6Z A;  1QXZ A;  1W7V A;  2GG0 A;  5JI6 A;  2Q92 A;  4IF7 A;  4U6C A;  4PNC A;  4RZZ A;  3L24 A;  5E5B A;  2B3K A;  5CDL A;  2DFI A;  4JUQ A;  2BN7 A;  2EVM A;  1C23 A;  4U76 A;  3IU8 A;  4FLL A;  4OOK A;  1WLR A;  2MAT A;  4A6W A;  2V3Y A;  4FKC A;  5CNX A;  5CDE A;  3PKC A;  5CE6 A;  1YW8 A;  4IDY A;  2GU4 A;  4IKU A;  2EA2 A;  4IKT A;  1JAW A;  2V3X A;  4FLK A;  5CIK A;  5D6F A;  2BWU A;  4ZWP A;  2GG9 A;  2G6P A;  4IPA A;  4EGE A;  3BIQ A;  2GU6 A;  3PKD A;  1WY2 A;  1BN5 A;  2GG2 A;  2Q93 A;  3CB5 A;  2EA4 A;  3Q6D A;  1QXY A;  5FCH A;  4RZY A;  1C21 A;  1N51 A;  2BHB A;  1Y1N A;  1QXW A;  4U75 A;  2BH3 A;  2BWT A;  4IKS A;  2EVC A;  4U70 A;  4RGZ 1;  4U69 A;  1B59 A;  3FMR A;  3ROR A;  2GTX A;  2Q94 A;  5CLS A;  1W2M A;  2BWV A;  4FLJ A;  3CTZ A;  3MX6 A;  3BIT A;  1WL6 A;  2GG3 A;  5FCF A;  1YW9 A;  1YW7 A;  2BWX A;  2HOW A;  2P98 A;  1B6A A;  1C27 A;  2ZSG A;  3TAV A;  3RVA A;  4Z7M A;  1XGO A;  1A16 A;  2BWW A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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