1C23A

E. coli methionine aminopeptidase: methionine phosphonate complex
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli
publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
molecule keywords METHIONINE AMINOPEPTIDASE
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c23A00
5CDLA 2Q93A 2ZSGA 2BWSA 4IKRA 2EVMA 4U75A 4U73A 4FLLA 3BIPA 1MATA 2DFIA 5JFRA 2B3KA 2Q95A 1C24A 3PKBA 1YW9A 1C22A 2GA2A 3BIQA 1WL6A 4ZWOA 1XGNA 4PNCA 4ZWUA 1B6AA 1C21A 5E5BA 4S01A 2V3XA 1Y1NA 4U1BA 3Q6DA 5D6FA 4RZZA 4U6EA 2IW2A 2B3LA 3L24A 1KQ9A 3IU8A 3FM3A 1KP0A 4IKSA 2P99A 3PKCA 1XGMA 3CTZA 2EVOA 5CDEA 3RVAA 2P98A 1YW8A 3TB5A 1R5GA 2GU6A 2OAZA 4FLKA 2HOWA 1YVMA 4IECA 4RGZ1 2BWXA 1YJ3A 1XNZA 2NQ6A 1KQ0A 2V3ZA 1C23A 4Z7MA 4FO7A 2NQ7A 4MATA 5CE6A 5CNXA 1QZYA 2Q96A 1R5HA 2GGBA 5CLSA 3IU7A 1WN1A 1B59A 2BHCA 2V6CA 2GG7A 2OKNA 2BHDA 2BHBA 4EGEA 1QXYA 4FKCA 1XGOA 2GGCA 4S2RP 5D6EA 4U70A 2V3YA 3S6BA 3MR1A 1WY2A 4U6CA 4IKUA 4B28A 1A16A 4U76A 3PKAA 4IU6A 4IDYA 2EA2A 3MATA 4R60A 1YW7A 2GZ5A 4S00A 4RZYA 5JHUA 4S2TP 2BHAA 4OOKA 1C27A 1W2MA 2BWUA 4U69A 2GG9A 2GG0A 2GU5A 1M35A 2Q92A 2Q8KA 2EA4A 3MX6A 1QXWA 1BOAA 2BN7A 4A6WA 4PV4A 1JAWA 5FCFA 1BN5A 1W7VA 2BB7A 3CB6A 3D27A 3FMRA 4A6VA 1WL9A 2GG5A 5CIKA 4FLIA 1XGSA 4FUKA 3BITA 5CDVA 2BH3A 2BWTA 4ZWPA 3FMQA 2BWVA 4FO8A 3L7GA 4IPAA 4U6WA 2GG3A 2MATA 3TAVA 2EVCA 1PV9A 1N51A 2GU7A 4QR8A 2BWYA 5FCHA 2GG2A 1R58A 2P9AA 2ADUA 3PKEA 3IG4A 3PKDA 1WBQA 4HXXA 5JI6A 2GU4A 3IU9A 2G6PA 4U6ZA 4IF7A 2GTXA 4IKTA 2Q94A 1WLRA 4JUQA 3RORA 1O0XA 3CB5A 4FLJA 2BWWA 4ZNGA 2B3HA 2GG8A 4U71A 4KM3A 1WKMA 1CHMA 1QXZA 4U6JA
chains in the Genus database with same CATH superfamily
5CDLA 2Q93A 2ZSGA 2BWSA 4IKRA 2EVMA 4U75A 4U73A 4FLLA 3BIPA 1MATA 2DFIA 5JFRA 2B3KA 2Q95A 1C24A 3PKBA 1YW9A 1C22A 2GA2A 3BIQA 1WL6A 4ZWOA 1XGNA 4PNCA 4ZWUA 1B6AA 1C21A 5E5BA 4S01A 2V3XA 1Y1NA 4U1BA 3Q6DA 5D6FA 4RZZA 4U6EA 2IW2A 2B3LA 3L24A 1KQ9A 3IU8A 3FM3A 1KP0A 4IKSA 2P99A 3PKCA 1XGMA 3CTZA 2EVOA 5CDEA 3RVAA 2P98A 1YW8A 3TB5A 1R5GA 2GU6A 2OAZA 4FLKA 2HOWA 1YVMA 4IECA 4RGZ1 2BWXA 1YJ3A 1XNZA 2NQ6A 1KQ0A 2V3ZA 1C23A 4Z7MA 4FO7A 2NQ7A 4MATA 5CE6A 5CNXA 1QZYA 2Q96A 1R5HA 2GGBA 5CLSA 3IU7A 1WN1A 1B59A 2BHCA 2V6CA 2GG7A 2OKNA 2BHDA 2BHBA 4EGEA 1QXYA 4FKCA 1XGOA 2GGCA 4S2RP 5D6EA 4U70A 2V3YA 3S6BA 3MR1A 1WY2A 4U6CA 4IKUA 4B28A 1A16A 4U76A 3PKAA 4IU6A 4IDYA 2EA2A 3MATA 4R60A 1YW7A 2GZ5A 4S00A 4RZYA 5JHUA 4S2TP 2BHAA 4OOKA 1C27A 1W2MA 2BWUA 4U69A 2GG9A 2GG0A 2GU5A 1M35A 2Q92A 2Q8KA 2EA4A 3MX6A 1QXWA 1BOAA 2BN7A 4A6WA 4PV4A 1JAWA 5FCFA 1BN5A 1W7VA 2BB7A 3CB6A 3D27A 3FMRA 4A6VA 1WL9A 2GG5A 5CIKA 4FLIA 1XGSA 4FUKA 3BITA 5CDVA 2BH3A 2BWTA 4ZWPA 3FMQA 2BWVA 4FO8A 3L7GA 4IPAA 4U6WA 2GG3A 2MATA 3TAVA 2EVCA 1PV9A 1N51A 2GU7A 4QR8A 2BWYA 5FCHA 2GG2A 1R58A 2P9AA 2ADUA 3PKEA 3IG4A 3PKDA 1WBQA 4HXXA 5JI6A 2GU4A 3IU9A 2G6PA 4U6ZA 4IF7A 2GTXA 4IKTA 2Q94A 1WLRA 4JUQA 3RORA 1O0XA 3CB5A 4FLJA 2BWWA 4ZNGA 2B3HA 2GG8A 4U71A 4KM3A 1WKMA 1CHMA 1QXZA 4U6JA
chains in the Genus database with same CATH topology
5CDLA 2Q93A 2ZSGA 2BWSA 4IKRA 2EVMA 4U75A 4U73A 4FLLA 3BIPA 1MATA 2DFIA 5JFRA 2B3KA 2Q95A 1C24A 3PKBA 1YW9A 1C22A 2GA2A 3BIQA 1WL6A 4ZWOA 1XGNA 4PNCA 4ZWUA 1B6AA 1C21A 5E5BA 4S01A 2V3XA 1Y1NA 4U1BA 3Q6DA 5D6FA 4RZZA 4U6EA 2IW2A 2B3LA 3L24A 1KQ9A 3IU8A 3FM3A 1KP0A 4IKSA 2P99A 3PKCA 1XGMA 3CTZA 2EVOA 5CDEA 3RVAA 2P98A 1YW8A 3TB5A 1R5GA 2GU6A 2OAZA 4FLKA 2HOWA 1YVMA 4IECA 4RGZ1 2BWXA 1YJ3A 1XNZA 2NQ6A 1KQ0A 2V3ZA 1C23A 4Z7MA 4FO7A 2NQ7A 4MATA 5CE6A 5CNXA 1QZYA 2Q96A 1R5HA 2GGBA 5CLSA 3IU7A 1WN1A 1B59A 2BHCA 2V6CA 2GG7A 2OKNA 2BHDA 2BHBA 4EGEA 1QXYA 4FKCA 1XGOA 2GGCA 4S2RP 5D6EA 4U70A 2V3YA 3S6BA 3MR1A 1WY2A 4U6CA 4IKUA 4B28A 1A16A 4U76A 3PKAA 4IU6A 4IDYA 2EA2A 3MATA 4R60A 1YW7A 2GZ5A 4S00A 4RZYA 5JHUA 4S2TP 2BHAA 4OOKA 1C27A 1W2MA 2BWUA 4U69A 2GG9A 2GG0A 2GU5A 1M35A 2Q92A 2Q8KA 2EA4A 3MX6A 1QXWA 1BOAA 2BN7A 4A6WA 4PV4A 1JAWA 5FCFA 1BN5A 1W7VA 2BB7A 3CB6A 3D27A 3FMRA 4A6VA 1WL9A 2GG5A 5CIKA 4FLIA 1XGSA 4FUKA 3BITA 5CDVA 2BH3A 2BWTA 4ZWPA 3FMQA 2BWVA 4FO8A 3L7GA 4IPAA 4U6WA 2GG3A 2MATA 3TAVA 2EVCA 1PV9A 1N51A 2GU7A 4QR8A 2BWYA 5FCHA 2GG2A 1R58A 2P9AA 2ADUA 3PKEA 3IG4A 3PKDA 1WBQA 4HXXA 5JI6A 2GU4A 3IU9A 2G6PA 4U6ZA 4IF7A 2GTXA 4IKTA 2Q94A 1WLRA 4JUQA 3RORA 1O0XA 3CB5A 4FLJA 2BWWA 4ZNGA 2B3HA 2GG8A 4U71A 4KM3A 1WKMA 1CHMA 1QXZA 4U6JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CDL A;  2Q93 A;  2ZSG A;  2BWS A;  4IKR A;  2EVM A;  4U75 A;  4U73 A;  4FLL A;  3BIP A;  1MAT A;  2DFI A;  5JFR A;  2B3K A;  2Q95 A;  1C24 A;  3PKB A;  1YW9 A;  1C22 A;  2GA2 A;  3BIQ A;  1WL6 A;  4ZWO A;  1XGN A;  4PNC A;  4ZWU A;  1B6A A;  1C21 A;  5E5B A;  4S01 A;  2V3X A;  1Y1N A;  4U1B A;  3Q6D A;  5D6F A;  4RZZ A;  4U6E A;  2IW2 A;  2B3L A;  3L24 A;  1KQ9 A;  3IU8 A;  3FM3 A;  1KP0 A;  4IKS A;  2P99 A;  3PKC A;  1XGM A;  3CTZ A;  2EVO A;  5CDE A;  3RVA A;  2P98 A;  1YW8 A;  3TB5 A;  1R5G A;  2GU6 A;  2OAZ A;  4FLK A;  2HOW A;  1YVM A;  4IEC A;  4RGZ 1;  2BWX A;  1YJ3 A;  1XNZ A;  2NQ6 A;  1KQ0 A;  2V3Z A;  1C23 A;  4Z7M A;  4FO7 A;  2NQ7 A;  4MAT A;  5CE6 A;  5CNX A;  1QZY A;  2Q96 A;  1R5H A;  2GGB A;  5CLS A;  3IU7 A;  1WN1 A;  1B59 A;  2BHC A;  2V6C A;  2GG7 A;  2OKN A;  2BHD A;  2BHB A;  4EGE A;  1QXY A;  4FKC A;  1XGO A;  2GGC A;  4S2R P;  5D6E A;  4U70 A;  2V3Y A;  3S6B A;  3MR1 A;  1WY2 A;  4U6C A;  4IKU A;  4B28 A;  1A16 A;  4U76 A;  3PKA A;  4IU6 A;  4IDY A;  2EA2 A;  3MAT A;  4R60 A;  1YW7 A;  2GZ5 A;  4S00 A;  4RZY A;  5JHU A;  4S2T P;  2BHA A;  4OOK A;  1C27 A;  1W2M A;  2BWU A;  4U69 A;  2GG9 A;  2GG0 A;  2GU5 A;  1M35 A;  2Q92 A;  2Q8K A;  2EA4 A;  3MX6 A;  1QXW A;  1BOA A;  2BN7 A;  4A6W A;  4PV4 A;  1JAW A;  5FCF A;  1BN5 A;  1W7V A;  2BB7 A;  3CB6 A;  3D27 A;  3FMR A;  4A6V A;  1WL9 A;  2GG5 A;  5CIK A;  4FLI A;  1XGS A;  4FUK A;  3BIT A;  5CDV A;  2BH3 A;  2BWT A;  4ZWP A;  3FMQ A;  2BWV A;  4FO8 A;  3L7G A;  4IPA A;  4U6W A;  2GG3 A;  2MAT A;  3TAV A;  2EVC A;  1PV9 A;  1N51 A;  2GU7 A;  4QR8 A;  2BWY A;  5FCH A;  2GG2 A;  1R58 A;  2P9A A;  2ADU A;  3PKE A;  3IG4 A;  3PKD A;  1WBQ A;  4HXX A;  5JI6 A;  2GU4 A;  3IU9 A;  2G6P A;  4U6Z A;  4IF7 A;  2GTX A;  4IKT A;  2Q94 A;  1WLR A;  4JUQ A;  3ROR A;  1O0X A;  3CB5 A;  4FLJ A;  2BWW A;  4ZNG A;  2B3H A;  2GG8 A;  4U71 A;  4KM3 A;  1WKM A;  1CHM A;  1QXZ A;  4U6J A; 
#chains in the Genus database with same CATH topology
 5CDL A;  2Q93 A;  2ZSG A;  2BWS A;  4IKR A;  2EVM A;  4U75 A;  4U73 A;  4FLL A;  3BIP A;  1MAT A;  2DFI A;  5JFR A;  2B3K A;  2Q95 A;  1C24 A;  3PKB A;  1YW9 A;  1C22 A;  2GA2 A;  3BIQ A;  1WL6 A;  4ZWO A;  1XGN A;  4PNC A;  4ZWU A;  1B6A A;  1C21 A;  5E5B A;  4S01 A;  2V3X A;  1Y1N A;  4U1B A;  3Q6D A;  5D6F A;  4RZZ A;  4U6E A;  2IW2 A;  2B3L A;  3L24 A;  1KQ9 A;  3IU8 A;  3FM3 A;  1KP0 A;  4IKS A;  2P99 A;  3PKC A;  1XGM A;  3CTZ A;  2EVO A;  5CDE A;  3RVA A;  2P98 A;  1YW8 A;  3TB5 A;  1R5G A;  2GU6 A;  2OAZ A;  4FLK A;  2HOW A;  1YVM A;  4IEC A;  4RGZ 1;  2BWX A;  1YJ3 A;  1XNZ A;  2NQ6 A;  1KQ0 A;  2V3Z A;  1C23 A;  4Z7M A;  4FO7 A;  2NQ7 A;  4MAT A;  5CE6 A;  5CNX A;  1QZY A;  2Q96 A;  1R5H A;  2GGB A;  5CLS A;  3IU7 A;  1WN1 A;  1B59 A;  2BHC A;  2V6C A;  2GG7 A;  2OKN A;  2BHD A;  2BHB A;  4EGE A;  1QXY A;  4FKC A;  1XGO A;  2GGC A;  4S2R P;  5D6E A;  4U70 A;  2V3Y A;  3S6B A;  3MR1 A;  1WY2 A;  4U6C A;  4IKU A;  4B28 A;  1A16 A;  4U76 A;  3PKA A;  4IU6 A;  4IDY A;  2EA2 A;  3MAT A;  4R60 A;  1YW7 A;  2GZ5 A;  4S00 A;  4RZY A;  5JHU A;  4S2T P;  2BHA A;  4OOK A;  1C27 A;  1W2M A;  2BWU A;  4U69 A;  2GG9 A;  2GG0 A;  2GU5 A;  1M35 A;  2Q92 A;  2Q8K A;  2EA4 A;  3MX6 A;  1QXW A;  1BOA A;  2BN7 A;  4A6W A;  4PV4 A;  1JAW A;  5FCF A;  1BN5 A;  1W7V A;  2BB7 A;  3CB6 A;  3D27 A;  3FMR A;  4A6V A;  1WL9 A;  2GG5 A;  5CIK A;  4FLI A;  1XGS A;  4FUK A;  3BIT A;  5CDV A;  2BH3 A;  2BWT A;  4ZWP A;  3FMQ A;  2BWV A;  4FO8 A;  3L7G A;  4IPA A;  4U6W A;  2GG3 A;  2MAT A;  3TAV A;  2EVC A;  1PV9 A;  1N51 A;  2GU7 A;  4QR8 A;  2BWY A;  5FCH A;  2GG2 A;  1R58 A;  2P9A A;  2ADU A;  3PKE A;  3IG4 A;  3PKD A;  1WBQ A;  4HXX A;  5JI6 A;  2GU4 A;  3IU9 A;  2G6P A;  4U6Z A;  4IF7 A;  2GTX A;  4IKT A;  2Q94 A;  1WLR A;  4JUQ A;  3ROR A;  1O0X A;  3CB5 A;  4FLJ A;  2BWW A;  4ZNG A;  2B3H A;  2GG8 A;  4U71 A;  4KM3 A;  1WKM A;  1CHM A;  1QXZ A;  4U6J A; 
#chains in the Genus database with same CATH homology
 5CDL A;  2Q93 A;  2ZSG A;  2BWS A;  4IKR A;  2EVM A;  4U75 A;  4U73 A;  4FLL A;  3BIP A;  1MAT A;  2DFI A;  5JFR A;  2B3K A;  2Q95 A;  1C24 A;  3PKB A;  1YW9 A;  1C22 A;  2GA2 A;  3BIQ A;  1WL6 A;  4ZWO A;  1XGN A;  4PNC A;  4ZWU A;  1B6A A;  1C21 A;  5E5B A;  4S01 A;  2V3X A;  1Y1N A;  4U1B A;  3Q6D A;  5D6F A;  4RZZ A;  4U6E A;  2IW2 A;  2B3L A;  3L24 A;  1KQ9 A;  3IU8 A;  3FM3 A;  1KP0 A;  4IKS A;  2P99 A;  3PKC A;  1XGM A;  3CTZ A;  2EVO A;  5CDE A;  3RVA A;  2P98 A;  1YW8 A;  3TB5 A;  1R5G A;  2GU6 A;  2OAZ A;  4FLK A;  2HOW A;  1YVM A;  4IEC A;  4RGZ 1;  2BWX A;  1YJ3 A;  1XNZ A;  2NQ6 A;  1KQ0 A;  2V3Z A;  1C23 A;  4Z7M A;  4FO7 A;  2NQ7 A;  4MAT A;  5CE6 A;  5CNX A;  1QZY A;  2Q96 A;  1R5H A;  2GGB A;  5CLS A;  3IU7 A;  1WN1 A;  1B59 A;  2BHC A;  2V6C A;  2GG7 A;  2OKN A;  2BHD A;  2BHB A;  4EGE A;  1QXY A;  4FKC A;  1XGO A;  2GGC A;  4S2R P;  5D6E A;  4U70 A;  2V3Y A;  3S6B A;  3MR1 A;  1WY2 A;  4U6C A;  4IKU A;  4B28 A;  1A16 A;  4U76 A;  3PKA A;  4IU6 A;  4IDY A;  2EA2 A;  3MAT A;  4R60 A;  1YW7 A;  2GZ5 A;  4S00 A;  4RZY A;  5JHU A;  4S2T P;  2BHA A;  4OOK A;  1C27 A;  1W2M A;  2BWU A;  4U69 A;  2GG9 A;  2GG0 A;  2GU5 A;  1M35 A;  2Q92 A;  2Q8K A;  2EA4 A;  3MX6 A;  1QXW A;  1BOA A;  2BN7 A;  4A6W A;  4PV4 A;  1JAW A;  5FCF A;  1BN5 A;  1W7V A;  2BB7 A;  3CB6 A;  3D27 A;  3FMR A;  4A6V A;  1WL9 A;  2GG5 A;  5CIK A;  4FLI A;  1XGS A;  4FUK A;  3BIT A;  5CDV A;  2BH3 A;  2BWT A;  4ZWP A;  3FMQ A;  2BWV A;  4FO8 A;  3L7G A;  4IPA A;  4U6W A;  2GG3 A;  2MAT A;  3TAV A;  2EVC A;  1PV9 A;  1N51 A;  2GU7 A;  4QR8 A;  2BWY A;  5FCH A;  2GG2 A;  1R58 A;  2P9A A;  2ADU A;  3PKE A;  3IG4 A;  3PKD A;  1WBQ A;  4HXX A;  5JI6 A;  2GU4 A;  3IU9 A;  2G6P A;  4U6Z A;  4IF7 A;  2GTX A;  4IKT A;  2Q94 A;  1WLR A;  4JUQ A;  3ROR A;  1O0X A;  3CB5 A;  4FLJ A;  2BWW A;  4ZNG A;  2B3H A;  2GG8 A;  4U71 A;  4KM3 A;  1WKM A;  1CHM A;  1QXZ A;  4U6J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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