1C27A

E. coli methionine aminopeptidase:norleucine phosphonate complex
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords METHIONINE AMINOPEPTIDASE
total genus 85
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c27A00
1WBQA 2BWWA 4OOKA 1WL6A 4A6VA 4Z7MA 1QXWA 4U6JA 1XGMA 1C22A 5D6EA 5CLSA 2Q8KA 1XGNA 2GU6A 4B28A 4FLKA 4R60A 2BHAA 1W2MA 5JHUA 1KQ0A 3IU7A 1QXYA 2BWSA 1BN5A 1R5HA 4S2TP 2GG5A 1C23A 2B3KA 1Y1NA 2IW2A 3S6BA 4U6EA 2BN7A 2P9AA 2GG8A 3Q6DA 1WY2A 1PV9A 2GGBA 4U6CA 5E5BA 5FCHA 1CHMA 1C21A 4FUKA 4IECA 1O0XA 2Q92A 2GU5A 2MATA 2P98A 2HOWA 4HXXA 4PNCA 4S2RP 4ZWPA 1QXZA 2OAZA 4KM3A 2EVOA 4IDYA 2BWYA 2GG0A 3TAVA 1KP0A 3PKEA 2GG7A 2GU4A 3MR1A 1JAWA 1YW8A 2BHCA 3L7GA 1B6AA 2GG3A 4JUQA 4FLIA 2BWUA 2NQ6A 4U69A 2GG9A 3CB6A 2BWTA 2GG2A 2Q96A 1YJ3A 2BB7A 4IKUA 4FLJA 1C24A 2GU7A 2BWVA 3IU9A 1BOAA 1WLRA 4A6WA 2BH3A 2V3YA 4IKTA 5CE6A 3CB5A 3RORA 2EA2A 5FCFA 3BIQA 2ZSGA 1XGOA 4IKSA 1B59A 3FM3A 4IU6A 2P99A 4RZZA 1A16A 5CDVA 4S01A 2B3HA 2GTXA 1YVMA 2Q93A 2EA4A 2EVMA 4RZYA 5JI6A 1R58A 4RGZ1 4EGEA 4U1BA 4MATA 3PKAA 4FKCA 2EVCA 1WN1A 3IG4A 4U76A 3PKBA 2NQ7A 4IPAA 4QR8A 3CTZA 4PV4A 2V6CA 3FMRA 4IKRA 4U71A 5D6FA 4U73A 4ZNGA 4FLLA 1MATA 1WKMA 2G6PA 2B3LA 1C27A 3MATA 4S00A 2V3ZA 2Q94A 2GZ5A 5CIKA 4IF7A 3PKDA 1WL9A 4FO8A 3L24A 2DFIA 1W7VA 1KQ9A 2ADUA 2GGCA 3IU8A 4U75A 3RVAA 1XNZA 1YW9A 2BHDA 1QZYA 3MX6A 3PKCA 3BITA 2BHBA 5JFRA 1XGSA 1M35A 3FMQA 2Q95A 3BIPA 4ZWUA 2BWXA 4FO7A 5CDEA 3D27A 1R5GA 4ZWOA 2OKNA 4U6WA 4U70A 5CNXA 1YW7A 4U6ZA 5CDLA 2V3XA 2GA2A 3TB5A 1N51A
chains in the Genus database with same CATH superfamily
1WBQA 2BWWA 4OOKA 1WL6A 4A6VA 4Z7MA 1QXWA 4U6JA 1XGMA 1C22A 5D6EA 5CLSA 2Q8KA 1XGNA 2GU6A 4B28A 4FLKA 4R60A 2BHAA 1W2MA 5JHUA 1KQ0A 3IU7A 1QXYA 2BWSA 1BN5A 1R5HA 4S2TP 2GG5A 1C23A 2B3KA 1Y1NA 2IW2A 3S6BA 4U6EA 2BN7A 2P9AA 2GG8A 3Q6DA 1WY2A 1PV9A 2GGBA 4U6CA 5E5BA 5FCHA 1CHMA 1C21A 4FUKA 4IECA 1O0XA 2Q92A 2GU5A 2MATA 2P98A 2HOWA 4HXXA 4PNCA 4S2RP 4ZWPA 1QXZA 2OAZA 4KM3A 2EVOA 4IDYA 2BWYA 2GG0A 3TAVA 1KP0A 3PKEA 2GG7A 2GU4A 3MR1A 1JAWA 1YW8A 2BHCA 3L7GA 1B6AA 2GG3A 4JUQA 4FLIA 2BWUA 2NQ6A 4U69A 2GG9A 3CB6A 2BWTA 2GG2A 2Q96A 1YJ3A 2BB7A 4IKUA 4FLJA 1C24A 2GU7A 2BWVA 3IU9A 1BOAA 1WLRA 4A6WA 2BH3A 2V3YA 4IKTA 5CE6A 3CB5A 3RORA 2EA2A 5FCFA 3BIQA 2ZSGA 1XGOA 4IKSA 1B59A 3FM3A 4IU6A 2P99A 4RZZA 1A16A 5CDVA 4S01A 2B3HA 2GTXA 1YVMA 2Q93A 2EA4A 2EVMA 4RZYA 5JI6A 1R58A 4RGZ1 4EGEA 4U1BA 4MATA 3PKAA 4FKCA 2EVCA 1WN1A 3IG4A 4U76A 3PKBA 2NQ7A 4IPAA 4QR8A 3CTZA 4PV4A 2V6CA 3FMRA 4IKRA 4U71A 5D6FA 4U73A 4ZNGA 4FLLA 1MATA 1WKMA 2G6PA 2B3LA 1C27A 3MATA 4S00A 2V3ZA 2Q94A 2GZ5A 5CIKA 4IF7A 3PKDA 1WL9A 4FO8A 3L24A 2DFIA 1W7VA 1KQ9A 2ADUA 2GGCA 3IU8A 4U75A 3RVAA 1XNZA 1YW9A 2BHDA 1QZYA 3MX6A 3PKCA 3BITA 2BHBA 5JFRA 1XGSA 1M35A 3FMQA 2Q95A 3BIPA 4ZWUA 2BWXA 4FO7A 5CDEA 3D27A 1R5GA 4ZWOA 2OKNA 4U6WA 4U70A 5CNXA 1YW7A 4U6ZA 5CDLA 2V3XA 2GA2A 3TB5A 1N51A
chains in the Genus database with same CATH topology
1WBQA 2BWWA 4OOKA 1WL6A 4A6VA 4Z7MA 1QXWA 4U6JA 1XGMA 1C22A 5D6EA 5CLSA 2Q8KA 1XGNA 2GU6A 4B28A 4FLKA 4R60A 2BHAA 1W2MA 5JHUA 1KQ0A 3IU7A 1QXYA 2BWSA 1BN5A 1R5HA 4S2TP 2GG5A 1C23A 2B3KA 1Y1NA 2IW2A 3S6BA 4U6EA 2BN7A 2P9AA 2GG8A 3Q6DA 1WY2A 1PV9A 2GGBA 4U6CA 5E5BA 5FCHA 1CHMA 1C21A 4FUKA 4IECA 1O0XA 2Q92A 2GU5A 2MATA 2P98A 2HOWA 4HXXA 4PNCA 4S2RP 4ZWPA 1QXZA 2OAZA 4KM3A 2EVOA 4IDYA 2BWYA 2GG0A 3TAVA 1KP0A 3PKEA 2GG7A 2GU4A 3MR1A 1JAWA 1YW8A 2BHCA 3L7GA 1B6AA 2GG3A 4JUQA 4FLIA 2BWUA 2NQ6A 4U69A 2GG9A 3CB6A 2BWTA 2GG2A 2Q96A 1YJ3A 2BB7A 4IKUA 4FLJA 1C24A 2GU7A 2BWVA 3IU9A 1BOAA 1WLRA 4A6WA 2BH3A 2V3YA 4IKTA 5CE6A 3CB5A 3RORA 2EA2A 5FCFA 3BIQA 2ZSGA 1XGOA 4IKSA 1B59A 3FM3A 4IU6A 2P99A 4RZZA 1A16A 5CDVA 4S01A 2B3HA 2GTXA 1YVMA 2Q93A 2EA4A 2EVMA 4RZYA 5JI6A 1R58A 4RGZ1 4EGEA 4U1BA 4MATA 3PKAA 4FKCA 2EVCA 1WN1A 3IG4A 4U76A 3PKBA 2NQ7A 4IPAA 4QR8A 3CTZA 4PV4A 2V6CA 3FMRA 4IKRA 4U71A 5D6FA 4U73A 4ZNGA 4FLLA 1MATA 1WKMA 2G6PA 2B3LA 1C27A 3MATA 4S00A 2V3ZA 2Q94A 2GZ5A 5CIKA 4IF7A 3PKDA 1WL9A 4FO8A 3L24A 2DFIA 1W7VA 1KQ9A 2ADUA 2GGCA 3IU8A 4U75A 3RVAA 1XNZA 1YW9A 2BHDA 1QZYA 3MX6A 3PKCA 3BITA 2BHBA 5JFRA 1XGSA 1M35A 3FMQA 2Q95A 3BIPA 4ZWUA 2BWXA 4FO7A 5CDEA 3D27A 1R5GA 4ZWOA 2OKNA 4U6WA 4U70A 5CNXA 1YW7A 4U6ZA 5CDLA 2V3XA 2GA2A 3TB5A 1N51A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WBQ A;  2BWW A;  4OOK A;  1WL6 A;  4A6V A;  4Z7M A;  1QXW A;  4U6J A;  1XGM A;  1C22 A;  5D6E A;  5CLS A;  2Q8K A;  1XGN A;  2GU6 A;  4B28 A;  4FLK A;  4R60 A;  2BHA A;  1W2M A;  5JHU A;  1KQ0 A;  3IU7 A;  1QXY A;  2BWS A;  1BN5 A;  1R5H A;  4S2T P;  2GG5 A;  1C23 A;  2B3K A;  1Y1N A;  2IW2 A;  3S6B A;  4U6E A;  2BN7 A;  2P9A A;  2GG8 A;  3Q6D A;  1WY2 A;  1PV9 A;  2GGB A;  4U6C A;  5E5B A;  5FCH A;  1CHM A;  1C21 A;  4FUK A;  4IEC A;  1O0X A;  2Q92 A;  2GU5 A;  2MAT A;  2P98 A;  2HOW A;  4HXX A;  4PNC A;  4S2R P;  4ZWP A;  1QXZ A;  2OAZ A;  4KM3 A;  2EVO A;  4IDY A;  2BWY A;  2GG0 A;  3TAV A;  1KP0 A;  3PKE A;  2GG7 A;  2GU4 A;  3MR1 A;  1JAW A;  1YW8 A;  2BHC A;  3L7G A;  1B6A A;  2GG3 A;  4JUQ A;  4FLI A;  2BWU A;  2NQ6 A;  4U69 A;  2GG9 A;  3CB6 A;  2BWT A;  2GG2 A;  2Q96 A;  1YJ3 A;  2BB7 A;  4IKU A;  4FLJ A;  1C24 A;  2GU7 A;  2BWV A;  3IU9 A;  1BOA A;  1WLR A;  4A6W A;  2BH3 A;  2V3Y A;  4IKT A;  5CE6 A;  3CB5 A;  3ROR A;  2EA2 A;  5FCF A;  3BIQ A;  2ZSG A;  1XGO A;  4IKS A;  1B59 A;  3FM3 A;  4IU6 A;  2P99 A;  4RZZ A;  1A16 A;  5CDV A;  4S01 A;  2B3H A;  2GTX A;  1YVM A;  2Q93 A;  2EA4 A;  2EVM A;  4RZY A;  5JI6 A;  1R58 A;  4RGZ 1;  4EGE A;  4U1B A;  4MAT A;  3PKA A;  4FKC A;  2EVC A;  1WN1 A;  3IG4 A;  4U76 A;  3PKB A;  2NQ7 A;  4IPA A;  4QR8 A;  3CTZ A;  4PV4 A;  2V6C A;  3FMR A;  4IKR A;  4U71 A;  5D6F A;  4U73 A;  4ZNG A;  4FLL A;  1MAT A;  1WKM A;  2G6P A;  2B3L A;  1C27 A;  3MAT A;  4S00 A;  2V3Z A;  2Q94 A;  2GZ5 A;  5CIK A;  4IF7 A;  3PKD A;  1WL9 A;  4FO8 A;  3L24 A;  2DFI A;  1W7V A;  1KQ9 A;  2ADU A;  2GGC A;  3IU8 A;  4U75 A;  3RVA A;  1XNZ A;  1YW9 A;  2BHD A;  1QZY A;  3MX6 A;  3PKC A;  3BIT A;  2BHB A;  5JFR A;  1XGS A;  1M35 A;  3FMQ A;  2Q95 A;  3BIP A;  4ZWU A;  2BWX A;  4FO7 A;  5CDE A;  3D27 A;  1R5G A;  4ZWO A;  2OKN A;  4U6W A;  4U70 A;  5CNX A;  1YW7 A;  4U6Z A;  5CDL A;  2V3X A;  2GA2 A;  3TB5 A;  1N51 A; 
#chains in the Genus database with same CATH topology
 1WBQ A;  2BWW A;  4OOK A;  1WL6 A;  4A6V A;  4Z7M A;  1QXW A;  4U6J A;  1XGM A;  1C22 A;  5D6E A;  5CLS A;  2Q8K A;  1XGN A;  2GU6 A;  4B28 A;  4FLK A;  4R60 A;  2BHA A;  1W2M A;  5JHU A;  1KQ0 A;  3IU7 A;  1QXY A;  2BWS A;  1BN5 A;  1R5H A;  4S2T P;  2GG5 A;  1C23 A;  2B3K A;  1Y1N A;  2IW2 A;  3S6B A;  4U6E A;  2BN7 A;  2P9A A;  2GG8 A;  3Q6D A;  1WY2 A;  1PV9 A;  2GGB A;  4U6C A;  5E5B A;  5FCH A;  1CHM A;  1C21 A;  4FUK A;  4IEC A;  1O0X A;  2Q92 A;  2GU5 A;  2MAT A;  2P98 A;  2HOW A;  4HXX A;  4PNC A;  4S2R P;  4ZWP A;  1QXZ A;  2OAZ A;  4KM3 A;  2EVO A;  4IDY A;  2BWY A;  2GG0 A;  3TAV A;  1KP0 A;  3PKE A;  2GG7 A;  2GU4 A;  3MR1 A;  1JAW A;  1YW8 A;  2BHC A;  3L7G A;  1B6A A;  2GG3 A;  4JUQ A;  4FLI A;  2BWU A;  2NQ6 A;  4U69 A;  2GG9 A;  3CB6 A;  2BWT A;  2GG2 A;  2Q96 A;  1YJ3 A;  2BB7 A;  4IKU A;  4FLJ A;  1C24 A;  2GU7 A;  2BWV A;  3IU9 A;  1BOA A;  1WLR A;  4A6W A;  2BH3 A;  2V3Y A;  4IKT A;  5CE6 A;  3CB5 A;  3ROR A;  2EA2 A;  5FCF A;  3BIQ A;  2ZSG A;  1XGO A;  4IKS A;  1B59 A;  3FM3 A;  4IU6 A;  2P99 A;  4RZZ A;  1A16 A;  5CDV A;  4S01 A;  2B3H A;  2GTX A;  1YVM A;  2Q93 A;  2EA4 A;  2EVM A;  4RZY A;  5JI6 A;  1R58 A;  4RGZ 1;  4EGE A;  4U1B A;  4MAT A;  3PKA A;  4FKC A;  2EVC A;  1WN1 A;  3IG4 A;  4U76 A;  3PKB A;  2NQ7 A;  4IPA A;  4QR8 A;  3CTZ A;  4PV4 A;  2V6C A;  3FMR A;  4IKR A;  4U71 A;  5D6F A;  4U73 A;  4ZNG A;  4FLL A;  1MAT A;  1WKM A;  2G6P A;  2B3L A;  1C27 A;  3MAT A;  4S00 A;  2V3Z A;  2Q94 A;  2GZ5 A;  5CIK A;  4IF7 A;  3PKD A;  1WL9 A;  4FO8 A;  3L24 A;  2DFI A;  1W7V A;  1KQ9 A;  2ADU A;  2GGC A;  3IU8 A;  4U75 A;  3RVA A;  1XNZ A;  1YW9 A;  2BHD A;  1QZY A;  3MX6 A;  3PKC A;  3BIT A;  2BHB A;  5JFR A;  1XGS A;  1M35 A;  3FMQ A;  2Q95 A;  3BIP A;  4ZWU A;  2BWX A;  4FO7 A;  5CDE A;  3D27 A;  1R5G A;  4ZWO A;  2OKN A;  4U6W A;  4U70 A;  5CNX A;  1YW7 A;  4U6Z A;  5CDL A;  2V3X A;  2GA2 A;  3TB5 A;  1N51 A; 
#chains in the Genus database with same CATH homology
 1WBQ A;  2BWW A;  4OOK A;  1WL6 A;  4A6V A;  4Z7M A;  1QXW A;  4U6J A;  1XGM A;  1C22 A;  5D6E A;  5CLS A;  2Q8K A;  1XGN A;  2GU6 A;  4B28 A;  4FLK A;  4R60 A;  2BHA A;  1W2M A;  5JHU A;  1KQ0 A;  3IU7 A;  1QXY A;  2BWS A;  1BN5 A;  1R5H A;  4S2T P;  2GG5 A;  1C23 A;  2B3K A;  1Y1N A;  2IW2 A;  3S6B A;  4U6E A;  2BN7 A;  2P9A A;  2GG8 A;  3Q6D A;  1WY2 A;  1PV9 A;  2GGB A;  4U6C A;  5E5B A;  5FCH A;  1CHM A;  1C21 A;  4FUK A;  4IEC A;  1O0X A;  2Q92 A;  2GU5 A;  2MAT A;  2P98 A;  2HOW A;  4HXX A;  4PNC A;  4S2R P;  4ZWP A;  1QXZ A;  2OAZ A;  4KM3 A;  2EVO A;  4IDY A;  2BWY A;  2GG0 A;  3TAV A;  1KP0 A;  3PKE A;  2GG7 A;  2GU4 A;  3MR1 A;  1JAW A;  1YW8 A;  2BHC A;  3L7G A;  1B6A A;  2GG3 A;  4JUQ A;  4FLI A;  2BWU A;  2NQ6 A;  4U69 A;  2GG9 A;  3CB6 A;  2BWT A;  2GG2 A;  2Q96 A;  1YJ3 A;  2BB7 A;  4IKU A;  4FLJ A;  1C24 A;  2GU7 A;  2BWV A;  3IU9 A;  1BOA A;  1WLR A;  4A6W A;  2BH3 A;  2V3Y A;  4IKT A;  5CE6 A;  3CB5 A;  3ROR A;  2EA2 A;  5FCF A;  3BIQ A;  2ZSG A;  1XGO A;  4IKS A;  1B59 A;  3FM3 A;  4IU6 A;  2P99 A;  4RZZ A;  1A16 A;  5CDV A;  4S01 A;  2B3H A;  2GTX A;  1YVM A;  2Q93 A;  2EA4 A;  2EVM A;  4RZY A;  5JI6 A;  1R58 A;  4RGZ 1;  4EGE A;  4U1B A;  4MAT A;  3PKA A;  4FKC A;  2EVC A;  1WN1 A;  3IG4 A;  4U76 A;  3PKB A;  2NQ7 A;  4IPA A;  4QR8 A;  3CTZ A;  4PV4 A;  2V6C A;  3FMR A;  4IKR A;  4U71 A;  5D6F A;  4U73 A;  4ZNG A;  4FLL A;  1MAT A;  1WKM A;  2G6P A;  2B3L A;  1C27 A;  3MAT A;  4S00 A;  2V3Z A;  2Q94 A;  2GZ5 A;  5CIK A;  4IF7 A;  3PKD A;  1WL9 A;  4FO8 A;  3L24 A;  2DFI A;  1W7V A;  1KQ9 A;  2ADU A;  2GGC A;  3IU8 A;  4U75 A;  3RVA A;  1XNZ A;  1YW9 A;  2BHD A;  1QZY A;  3MX6 A;  3PKC A;  3BIT A;  2BHB A;  5JFR A;  1XGS A;  1M35 A;  3FMQ A;  2Q95 A;  3BIP A;  4ZWU A;  2BWX A;  4FO7 A;  5CDE A;  3D27 A;  1R5G A;  4ZWO A;  2OKN A;  4U6W A;  4U70 A;  5CNX A;  1YW7 A;  4U6Z A;  5CDL A;  2V3X A;  2GA2 A;  3TB5 A;  1N51 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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