1QXWA

Crystal structure of staphyloccocus aureus in complex with an aminoketone inhibitor 54135.
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
249
structure length
249
Chain Sequence
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Staphylococcus aureus
publication title Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.
pubmed doi rcsb
molecule keywords methionyl aminopeptidase
total genus 82
structure length 249
sequence length 249
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2003-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1qxwA00
1MATA 2V3YA 2GU5A 2BWWA 1WL6A 2GU4A 2Q92A 4JUQA 4IKTA 3IU8A 2BH3A 1R5HA 2BWYA 2GA2A 1QXYA 4U6CA 2V3ZA 4FKCA 1QXWA 3CTZA 2GG5A 4FO7A 5E5BA 1KQ0A 3D27A 2Q8KA 2GTXA 4A6WA 2BHBA 3TB5A 3MATA 4IKSA 3MX6A 2GU6A 1YW8A 2DFIA 4MATA 1WL9A 4U6WA 4RGZ1 3BIPA 3TAVA 4EGEA 1YVMA 4U6EA 3PKBA 3BIQA 2P98A 2EA2A 2BHAA 1B6AA 4U6ZA 4R60A 1M35A 4ZWPA 1W7VA 4IKUA 4S2TP 3PKDA 4A6VA 4RZYA 4QR8A 2V6CA 1CHMA 2V3XA 3FMQA 1C27A 4OOKA 4U76A 2GG0A 1Y1NA 4IF7A 4U75A 2EA4A 2BWXA 2HOWA 1R58A 4S00A 2OAZA 1YW9A 5JFRA 2GG8A 2BB7A 3FM3A 4U69A 2BN7A 2GGBA 4IKRA 4U1BA 3IG4A 2NQ6A 4FLLA 1KP0A 1XGMA 1C21A 2BHCA 4IPAA 4FUKA 1XGSA 5CNXA 2EVMA 1WLRA 2Q93A 3Q6DA 5CDEA 1N51A 4ZWUA 1PV9A 2GG9A 2GG2A 3CB6A 3RVAA 1BOAA 1C23A 1XNZA 4HXXA 1KQ9A 1WN1A 2BWSA 2GG3A 2Q94A 2GGCA 3IU7A 4FLKA 3L7GA 5JI6A 4S2RP 4B28A 5CIKA 4U71A 4FLJA 2ADUA 4FLIA 2EVOA 4IU6A 4U6JA 2B3KA 2BWTA 2BWUA 2BWVA 2GG7A 2ZSGA 4IECA 3IU9A 1WKMA 1YJ3A 4U70A 1WBQA 1B59A 2Q96A 2B3LA 3L24A 5FCFA 4KM3A 4PNCA 2IW2A 2G6PA 3PKAA 2Q95A 1JAWA 5CE6A 1R5GA 4PV4A 1A16A 1O0XA 2GU7A 5CDVA 5D6FA 4Z7MA 5FCHA 3PKEA 3S6BA 2BHDA 1W2MA 4ZNGA 2P9AA 2GZ5A 4S01A 4IDYA 5D6EA 5CDLA 3FMRA 2B3HA 4ZWOA 1WY2A 3CB5A 3RORA 1C24A 3BITA 1QZYA 2MATA 3MR1A 4U73A 1XGNA 2OKNA 2P99A 2EVCA 1C22A 3PKCA 4RZZA 5JHUA 4FO8A 1BN5A 5CLSA 1QXZA 1XGOA 1YW7A 2NQ7A
chains in the Genus database with same CATH superfamily
1MATA 2V3YA 2GU5A 2BWWA 1WL6A 2GU4A 2Q92A 4JUQA 4IKTA 3IU8A 2BH3A 1R5HA 2BWYA 2GA2A 1QXYA 4U6CA 2V3ZA 4FKCA 1QXWA 3CTZA 2GG5A 4FO7A 5E5BA 1KQ0A 3D27A 2Q8KA 2GTXA 4A6WA 2BHBA 3TB5A 3MATA 4IKSA 3MX6A 2GU6A 1YW8A 2DFIA 4MATA 1WL9A 4U6WA 4RGZ1 3BIPA 3TAVA 4EGEA 1YVMA 4U6EA 3PKBA 3BIQA 2P98A 2EA2A 2BHAA 1B6AA 4U6ZA 4R60A 1M35A 4ZWPA 1W7VA 4IKUA 4S2TP 3PKDA 4A6VA 4RZYA 4QR8A 2V6CA 1CHMA 2V3XA 3FMQA 1C27A 4OOKA 4U76A 2GG0A 1Y1NA 4IF7A 4U75A 2EA4A 2BWXA 2HOWA 1R58A 4S00A 2OAZA 1YW9A 5JFRA 2GG8A 2BB7A 3FM3A 4U69A 2BN7A 2GGBA 4IKRA 4U1BA 3IG4A 2NQ6A 4FLLA 1KP0A 1XGMA 1C21A 2BHCA 4IPAA 4FUKA 1XGSA 5CNXA 2EVMA 1WLRA 2Q93A 3Q6DA 5CDEA 1N51A 4ZWUA 1PV9A 2GG9A 2GG2A 3CB6A 3RVAA 1BOAA 1C23A 1XNZA 4HXXA 1KQ9A 1WN1A 2BWSA 2GG3A 2Q94A 2GGCA 3IU7A 4FLKA 3L7GA 5JI6A 4S2RP 4B28A 5CIKA 4U71A 4FLJA 2ADUA 4FLIA 2EVOA 4IU6A 4U6JA 2B3KA 2BWTA 2BWUA 2BWVA 2GG7A 2ZSGA 4IECA 3IU9A 1WKMA 1YJ3A 4U70A 1WBQA 1B59A 2Q96A 2B3LA 3L24A 5FCFA 4KM3A 4PNCA 2IW2A 2G6PA 3PKAA 2Q95A 1JAWA 5CE6A 1R5GA 4PV4A 1A16A 1O0XA 2GU7A 5CDVA 5D6FA 4Z7MA 5FCHA 3PKEA 3S6BA 2BHDA 1W2MA 4ZNGA 2P9AA 2GZ5A 4S01A 4IDYA 5D6EA 5CDLA 3FMRA 2B3HA 4ZWOA 1WY2A 3CB5A 3RORA 1C24A 3BITA 1QZYA 2MATA 3MR1A 4U73A 1XGNA 2OKNA 2P99A 2EVCA 1C22A 3PKCA 4RZZA 5JHUA 4FO8A 1BN5A 5CLSA 1QXZA 1XGOA 1YW7A 2NQ7A
chains in the Genus database with same CATH topology
1MATA 2V3YA 2GU5A 2BWWA 1WL6A 2GU4A 2Q92A 4JUQA 4IKTA 3IU8A 2BH3A 1R5HA 2BWYA 2GA2A 1QXYA 4U6CA 2V3ZA 4FKCA 1QXWA 3CTZA 2GG5A 4FO7A 5E5BA 1KQ0A 3D27A 2Q8KA 2GTXA 4A6WA 2BHBA 3TB5A 3MATA 4IKSA 3MX6A 2GU6A 1YW8A 2DFIA 4MATA 1WL9A 4U6WA 4RGZ1 3BIPA 3TAVA 4EGEA 1YVMA 4U6EA 3PKBA 3BIQA 2P98A 2EA2A 2BHAA 1B6AA 4U6ZA 4R60A 1M35A 4ZWPA 1W7VA 4IKUA 4S2TP 3PKDA 4A6VA 4RZYA 4QR8A 2V6CA 1CHMA 2V3XA 3FMQA 1C27A 4OOKA 4U76A 2GG0A 1Y1NA 4IF7A 4U75A 2EA4A 2BWXA 2HOWA 1R58A 4S00A 2OAZA 1YW9A 5JFRA 2GG8A 2BB7A 3FM3A 4U69A 2BN7A 2GGBA 4IKRA 4U1BA 3IG4A 2NQ6A 4FLLA 1KP0A 1XGMA 1C21A 2BHCA 4IPAA 4FUKA 1XGSA 5CNXA 2EVMA 1WLRA 2Q93A 3Q6DA 5CDEA 1N51A 4ZWUA 1PV9A 2GG9A 2GG2A 3CB6A 3RVAA 1BOAA 1C23A 1XNZA 4HXXA 1KQ9A 1WN1A 2BWSA 2GG3A 2Q94A 2GGCA 3IU7A 4FLKA 3L7GA 5JI6A 4S2RP 4B28A 5CIKA 4U71A 4FLJA 2ADUA 4FLIA 2EVOA 4IU6A 4U6JA 2B3KA 2BWTA 2BWUA 2BWVA 2GG7A 2ZSGA 4IECA 3IU9A 1WKMA 1YJ3A 4U70A 1WBQA 1B59A 2Q96A 2B3LA 3L24A 5FCFA 4KM3A 4PNCA 2IW2A 2G6PA 3PKAA 2Q95A 1JAWA 5CE6A 1R5GA 4PV4A 1A16A 1O0XA 2GU7A 5CDVA 5D6FA 4Z7MA 5FCHA 3PKEA 3S6BA 2BHDA 1W2MA 4ZNGA 2P9AA 2GZ5A 4S01A 4IDYA 5D6EA 5CDLA 3FMRA 2B3HA 4ZWOA 1WY2A 3CB5A 3RORA 1C24A 3BITA 1QZYA 2MATA 3MR1A 4U73A 1XGNA 2OKNA 2P99A 2EVCA 1C22A 3PKCA 4RZZA 5JHUA 4FO8A 1BN5A 5CLSA 1QXZA 1XGOA 1YW7A 2NQ7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MAT A;  2V3Y A;  2GU5 A;  2BWW A;  1WL6 A;  2GU4 A;  2Q92 A;  4JUQ A;  4IKT A;  3IU8 A;  2BH3 A;  1R5H A;  2BWY A;  2GA2 A;  1QXY A;  4U6C A;  2V3Z A;  4FKC A;  1QXW A;  3CTZ A;  2GG5 A;  4FO7 A;  5E5B A;  1KQ0 A;  3D27 A;  2Q8K A;  2GTX A;  4A6W A;  2BHB A;  3TB5 A;  3MAT A;  4IKS A;  3MX6 A;  2GU6 A;  1YW8 A;  2DFI A;  4MAT A;  1WL9 A;  4U6W A;  4RGZ 1;  3BIP A;  3TAV A;  4EGE A;  1YVM A;  4U6E A;  3PKB A;  3BIQ A;  2P98 A;  2EA2 A;  2BHA A;  1B6A A;  4U6Z A;  4R60 A;  1M35 A;  4ZWP A;  1W7V A;  4IKU A;  4S2T P;  3PKD A;  4A6V A;  4RZY A;  4QR8 A;  2V6C A;  1CHM A;  2V3X A;  3FMQ A;  1C27 A;  4OOK A;  4U76 A;  2GG0 A;  1Y1N A;  4IF7 A;  4U75 A;  2EA4 A;  2BWX A;  2HOW A;  1R58 A;  4S00 A;  2OAZ A;  1YW9 A;  5JFR A;  2GG8 A;  2BB7 A;  3FM3 A;  4U69 A;  2BN7 A;  2GGB A;  4IKR A;  4U1B A;  3IG4 A;  2NQ6 A;  4FLL A;  1KP0 A;  1XGM A;  1C21 A;  2BHC A;  4IPA A;  4FUK A;  1XGS A;  5CNX A;  2EVM A;  1WLR A;  2Q93 A;  3Q6D A;  5CDE A;  1N51 A;  4ZWU A;  1PV9 A;  2GG9 A;  2GG2 A;  3CB6 A;  3RVA A;  1BOA A;  1C23 A;  1XNZ A;  4HXX A;  1KQ9 A;  1WN1 A;  2BWS A;  2GG3 A;  2Q94 A;  2GGC A;  3IU7 A;  4FLK A;  3L7G A;  5JI6 A;  4S2R P;  4B28 A;  5CIK A;  4U71 A;  4FLJ A;  2ADU A;  4FLI A;  2EVO A;  4IU6 A;  4U6J A;  2B3K A;  2BWT A;  2BWU A;  2BWV A;  2GG7 A;  2ZSG A;  4IEC A;  3IU9 A;  1WKM A;  1YJ3 A;  4U70 A;  1WBQ A;  1B59 A;  2Q96 A;  2B3L A;  3L24 A;  5FCF A;  4KM3 A;  4PNC A;  2IW2 A;  2G6P A;  3PKA A;  2Q95 A;  1JAW A;  5CE6 A;  1R5G A;  4PV4 A;  1A16 A;  1O0X A;  2GU7 A;  5CDV A;  5D6F A;  4Z7M A;  5FCH A;  3PKE A;  3S6B A;  2BHD A;  1W2M A;  4ZNG A;  2P9A A;  2GZ5 A;  4S01 A;  4IDY A;  5D6E A;  5CDL A;  3FMR A;  2B3H A;  4ZWO A;  1WY2 A;  3CB5 A;  3ROR A;  1C24 A;  3BIT A;  1QZY A;  2MAT A;  3MR1 A;  4U73 A;  1XGN A;  2OKN A;  2P99 A;  2EVC A;  1C22 A;  3PKC A;  4RZZ A;  5JHU A;  4FO8 A;  1BN5 A;  5CLS A;  1QXZ A;  1XGO A;  1YW7 A;  2NQ7 A; 
#chains in the Genus database with same CATH topology
 1MAT A;  2V3Y A;  2GU5 A;  2BWW A;  1WL6 A;  2GU4 A;  2Q92 A;  4JUQ A;  4IKT A;  3IU8 A;  2BH3 A;  1R5H A;  2BWY A;  2GA2 A;  1QXY A;  4U6C A;  2V3Z A;  4FKC A;  1QXW A;  3CTZ A;  2GG5 A;  4FO7 A;  5E5B A;  1KQ0 A;  3D27 A;  2Q8K A;  2GTX A;  4A6W A;  2BHB A;  3TB5 A;  3MAT A;  4IKS A;  3MX6 A;  2GU6 A;  1YW8 A;  2DFI A;  4MAT A;  1WL9 A;  4U6W A;  4RGZ 1;  3BIP A;  3TAV A;  4EGE A;  1YVM A;  4U6E A;  3PKB A;  3BIQ A;  2P98 A;  2EA2 A;  2BHA A;  1B6A A;  4U6Z A;  4R60 A;  1M35 A;  4ZWP A;  1W7V A;  4IKU A;  4S2T P;  3PKD A;  4A6V A;  4RZY A;  4QR8 A;  2V6C A;  1CHM A;  2V3X A;  3FMQ A;  1C27 A;  4OOK A;  4U76 A;  2GG0 A;  1Y1N A;  4IF7 A;  4U75 A;  2EA4 A;  2BWX A;  2HOW A;  1R58 A;  4S00 A;  2OAZ A;  1YW9 A;  5JFR A;  2GG8 A;  2BB7 A;  3FM3 A;  4U69 A;  2BN7 A;  2GGB A;  4IKR A;  4U1B A;  3IG4 A;  2NQ6 A;  4FLL A;  1KP0 A;  1XGM A;  1C21 A;  2BHC A;  4IPA A;  4FUK A;  1XGS A;  5CNX A;  2EVM A;  1WLR A;  2Q93 A;  3Q6D A;  5CDE A;  1N51 A;  4ZWU A;  1PV9 A;  2GG9 A;  2GG2 A;  3CB6 A;  3RVA A;  1BOA A;  1C23 A;  1XNZ A;  4HXX A;  1KQ9 A;  1WN1 A;  2BWS A;  2GG3 A;  2Q94 A;  2GGC A;  3IU7 A;  4FLK A;  3L7G A;  5JI6 A;  4S2R P;  4B28 A;  5CIK A;  4U71 A;  4FLJ A;  2ADU A;  4FLI A;  2EVO A;  4IU6 A;  4U6J A;  2B3K A;  2BWT A;  2BWU A;  2BWV A;  2GG7 A;  2ZSG A;  4IEC A;  3IU9 A;  1WKM A;  1YJ3 A;  4U70 A;  1WBQ A;  1B59 A;  2Q96 A;  2B3L A;  3L24 A;  5FCF A;  4KM3 A;  4PNC A;  2IW2 A;  2G6P A;  3PKA A;  2Q95 A;  1JAW A;  5CE6 A;  1R5G A;  4PV4 A;  1A16 A;  1O0X A;  2GU7 A;  5CDV A;  5D6F A;  4Z7M A;  5FCH A;  3PKE A;  3S6B A;  2BHD A;  1W2M A;  4ZNG A;  2P9A A;  2GZ5 A;  4S01 A;  4IDY A;  5D6E A;  5CDL A;  3FMR A;  2B3H A;  4ZWO A;  1WY2 A;  3CB5 A;  3ROR A;  1C24 A;  3BIT A;  1QZY A;  2MAT A;  3MR1 A;  4U73 A;  1XGN A;  2OKN A;  2P99 A;  2EVC A;  1C22 A;  3PKC A;  4RZZ A;  5JHU A;  4FO8 A;  1BN5 A;  5CLS A;  1QXZ A;  1XGO A;  1YW7 A;  2NQ7 A; 
#chains in the Genus database with same CATH homology
 1MAT A;  2V3Y A;  2GU5 A;  2BWW A;  1WL6 A;  2GU4 A;  2Q92 A;  4JUQ A;  4IKT A;  3IU8 A;  2BH3 A;  1R5H A;  2BWY A;  2GA2 A;  1QXY A;  4U6C A;  2V3Z A;  4FKC A;  1QXW A;  3CTZ A;  2GG5 A;  4FO7 A;  5E5B A;  1KQ0 A;  3D27 A;  2Q8K A;  2GTX A;  4A6W A;  2BHB A;  3TB5 A;  3MAT A;  4IKS A;  3MX6 A;  2GU6 A;  1YW8 A;  2DFI A;  4MAT A;  1WL9 A;  4U6W A;  4RGZ 1;  3BIP A;  3TAV A;  4EGE A;  1YVM A;  4U6E A;  3PKB A;  3BIQ A;  2P98 A;  2EA2 A;  2BHA A;  1B6A A;  4U6Z A;  4R60 A;  1M35 A;  4ZWP A;  1W7V A;  4IKU A;  4S2T P;  3PKD A;  4A6V A;  4RZY A;  4QR8 A;  2V6C A;  1CHM A;  2V3X A;  3FMQ A;  1C27 A;  4OOK A;  4U76 A;  2GG0 A;  1Y1N A;  4IF7 A;  4U75 A;  2EA4 A;  2BWX A;  2HOW A;  1R58 A;  4S00 A;  2OAZ A;  1YW9 A;  5JFR A;  2GG8 A;  2BB7 A;  3FM3 A;  4U69 A;  2BN7 A;  2GGB A;  4IKR A;  4U1B A;  3IG4 A;  2NQ6 A;  4FLL A;  1KP0 A;  1XGM A;  1C21 A;  2BHC A;  4IPA A;  4FUK A;  1XGS A;  5CNX A;  2EVM A;  1WLR A;  2Q93 A;  3Q6D A;  5CDE A;  1N51 A;  4ZWU A;  1PV9 A;  2GG9 A;  2GG2 A;  3CB6 A;  3RVA A;  1BOA A;  1C23 A;  1XNZ A;  4HXX A;  1KQ9 A;  1WN1 A;  2BWS A;  2GG3 A;  2Q94 A;  2GGC A;  3IU7 A;  4FLK A;  3L7G A;  5JI6 A;  4S2R P;  4B28 A;  5CIK A;  4U71 A;  4FLJ A;  2ADU A;  4FLI A;  2EVO A;  4IU6 A;  4U6J A;  2B3K A;  2BWT A;  2BWU A;  2BWV A;  2GG7 A;  2ZSG A;  4IEC A;  3IU9 A;  1WKM A;  1YJ3 A;  4U70 A;  1WBQ A;  1B59 A;  2Q96 A;  2B3L A;  3L24 A;  5FCF A;  4KM3 A;  4PNC A;  2IW2 A;  2G6P A;  3PKA A;  2Q95 A;  1JAW A;  5CE6 A;  1R5G A;  4PV4 A;  1A16 A;  1O0X A;  2GU7 A;  5CDV A;  5D6F A;  4Z7M A;  5FCH A;  3PKE A;  3S6B A;  2BHD A;  1W2M A;  4ZNG A;  2P9A A;  2GZ5 A;  4S01 A;  4IDY A;  5D6E A;  5CDL A;  3FMR A;  2B3H A;  4ZWO A;  1WY2 A;  3CB5 A;  3ROR A;  1C24 A;  3BIT A;  1QZY A;  2MAT A;  3MR1 A;  4U73 A;  1XGN A;  2OKN A;  2P99 A;  2EVC A;  1C22 A;  3PKC A;  4RZZ A;  5JHU A;  4FO8 A;  1BN5 A;  5CLS A;  1QXZ A;  1XGO A;  1YW7 A;  2NQ7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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