1QXYA

Crystal structure of s. aureus methionine aminopeptidase in complex with a ketoheterocycle 618
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
249
structure length
249
Chain Sequence
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKI
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Staphylococcus aureus
publication title Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.
pubmed doi rcsb
molecule keywords methionyl aminopeptidase
total genus 81
structure length 249
sequence length 249
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2003-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1qxyA00
1BN5A 4RZZA 5D6FA 3BIQA 2Q94A 3RORA 2Q96A 2BB7A 1JAWA 1XNZA 2GG3A 1PV9A 2BN7A 5FCFA 4RGZ1 4S00A 2NQ7A 1M35A 1YVMA 2P98A 1N51A 3CTZA 3L7GA 4U71A 2EA4A 2GG7A 1R5HA 1C23A 2Q93A 1XGMA 3IU9A 1WY2A 1C24A 1CHMA 3PKDA 3PKCA 3CB6A 4MATA 4U75A 2Q95A 2BWSA 3FMQA 3MR1A 4R60A 2EVOA 4U73A 2DFIA 2GG0A 2BWYA 5CE6A 2BH3A 1W2MA 4ZWUA 1KQ9A 2B3HA 3IG4A 1WKMA 4FLLA 1R58A 3MATA 1YJ3A 1R5GA 4Z7MA 1O0XA 1YW9A 1XGNA 2ZSGA 4QR8A 4FUKA 5JHUA 4IKRA 1WL9A 3D27A 4U6ZA 3FMRA 2GZ5A 5D6EA 3IU8A 1WN1A 2BHCA 1QXWA 2GG9A 1QXZA 4A6WA 4ZWOA 1MATA 5E5BA 5JFRA 2BWXA 2IW2A 4IU6A 2GG8A 2BHBA 4IDYA 2V6CA 2BWWA 2V3XA 4FLJA 1YW8A 4U6CA 3PKAA 1A16A 4U1BA 2GG2A 1KQ0A 4JUQA 1WL6A 2GGCA 1YW7A 2GU6A 4IF7A 2G6PA 1C22A 2BHDA 2GU7A 4OOKA 4KM3A 5CLSA 4IPAA 2OAZA 1Y1NA 2P9AA 4U70A 5CDLA 4FLKA 3L24A 3PKEA 4S2RP 4RZYA 4PNCA 4FO7A 5FCHA 2GU4A 3MX6A 1C27A 2BWVA 5JI6A 4FLIA 2GGBA 1WLRA 2ADUA 3S6BA 3Q6DA 3PKBA 3CB5A 4PV4A 3RVAA 3TAVA 3BIPA 1B6AA 2B3KA 1WBQA 2GTXA 2GG5A 4U76A 3IU7A 1KP0A 4B28A 2V3YA 2Q8KA 2EVMA 2P99A 4FKCA 2BWUA 4S01A 4U69A 4U6WA 4IKTA 2GA2A 2BHAA 2V3ZA 1B59A 2EA2A 2EVCA 5CIKA 2MATA 2BWTA 1BOAA 2NQ6A 4IECA 4ZWPA 1W7VA 1XGOA 2GU5A 1XGSA 2Q92A 4FO8A 4A6VA 2OKNA 5CDVA 3TB5A 3FM3A 4IKUA 4S2TP 4U6EA 4ZNGA 4IKSA 5CNXA 4EGEA 3BITA 5CDEA 1C21A 1QXYA 2B3LA 2HOWA 4HXXA 4U6JA 1QZYA
chains in the Genus database with same CATH superfamily
1BN5A 4RZZA 5D6FA 3BIQA 2Q94A 3RORA 2Q96A 2BB7A 1JAWA 1XNZA 2GG3A 1PV9A 2BN7A 5FCFA 4RGZ1 4S00A 2NQ7A 1M35A 1YVMA 2P98A 1N51A 3CTZA 3L7GA 4U71A 2EA4A 2GG7A 1R5HA 1C23A 2Q93A 1XGMA 3IU9A 1WY2A 1C24A 1CHMA 3PKDA 3PKCA 3CB6A 4MATA 4U75A 2Q95A 2BWSA 3FMQA 3MR1A 4R60A 2EVOA 4U73A 2DFIA 2GG0A 2BWYA 5CE6A 2BH3A 1W2MA 4ZWUA 1KQ9A 2B3HA 3IG4A 1WKMA 4FLLA 1R58A 3MATA 1YJ3A 1R5GA 4Z7MA 1O0XA 1YW9A 1XGNA 2ZSGA 4QR8A 4FUKA 5JHUA 4IKRA 1WL9A 3D27A 4U6ZA 3FMRA 2GZ5A 5D6EA 3IU8A 1WN1A 2BHCA 1QXWA 2GG9A 1QXZA 4A6WA 4ZWOA 1MATA 5E5BA 5JFRA 2BWXA 2IW2A 4IU6A 2GG8A 2BHBA 4IDYA 2V6CA 2BWWA 2V3XA 4FLJA 1YW8A 4U6CA 3PKAA 1A16A 4U1BA 2GG2A 1KQ0A 4JUQA 1WL6A 2GGCA 1YW7A 2GU6A 4IF7A 2G6PA 1C22A 2BHDA 2GU7A 4OOKA 4KM3A 5CLSA 4IPAA 2OAZA 1Y1NA 2P9AA 4U70A 5CDLA 4FLKA 3L24A 3PKEA 4S2RP 4RZYA 4PNCA 4FO7A 5FCHA 2GU4A 3MX6A 1C27A 2BWVA 5JI6A 4FLIA 2GGBA 1WLRA 2ADUA 3S6BA 3Q6DA 3PKBA 3CB5A 4PV4A 3RVAA 3TAVA 3BIPA 1B6AA 2B3KA 1WBQA 2GTXA 2GG5A 4U76A 3IU7A 1KP0A 4B28A 2V3YA 2Q8KA 2EVMA 2P99A 4FKCA 2BWUA 4S01A 4U69A 4U6WA 4IKTA 2GA2A 2BHAA 2V3ZA 1B59A 2EA2A 2EVCA 5CIKA 2MATA 2BWTA 1BOAA 2NQ6A 4IECA 4ZWPA 1W7VA 1XGOA 2GU5A 1XGSA 2Q92A 4FO8A 4A6VA 2OKNA 5CDVA 3TB5A 3FM3A 4IKUA 4S2TP 4U6EA 4ZNGA 4IKSA 5CNXA 4EGEA 3BITA 5CDEA 1C21A 1QXYA 2B3LA 2HOWA 4HXXA 4U6JA 1QZYA
chains in the Genus database with same CATH topology
1BN5A 4RZZA 5D6FA 3BIQA 2Q94A 3RORA 2Q96A 2BB7A 1JAWA 1XNZA 2GG3A 1PV9A 2BN7A 5FCFA 4RGZ1 4S00A 2NQ7A 1M35A 1YVMA 2P98A 1N51A 3CTZA 3L7GA 4U71A 2EA4A 2GG7A 1R5HA 1C23A 2Q93A 1XGMA 3IU9A 1WY2A 1C24A 1CHMA 3PKDA 3PKCA 3CB6A 4MATA 4U75A 2Q95A 2BWSA 3FMQA 3MR1A 4R60A 2EVOA 4U73A 2DFIA 2GG0A 2BWYA 5CE6A 2BH3A 1W2MA 4ZWUA 1KQ9A 2B3HA 3IG4A 1WKMA 4FLLA 1R58A 3MATA 1YJ3A 1R5GA 4Z7MA 1O0XA 1YW9A 1XGNA 2ZSGA 4QR8A 4FUKA 5JHUA 4IKRA 1WL9A 3D27A 4U6ZA 3FMRA 2GZ5A 5D6EA 3IU8A 1WN1A 2BHCA 1QXWA 2GG9A 1QXZA 4A6WA 4ZWOA 1MATA 5E5BA 5JFRA 2BWXA 2IW2A 4IU6A 2GG8A 2BHBA 4IDYA 2V6CA 2BWWA 2V3XA 4FLJA 1YW8A 4U6CA 3PKAA 1A16A 4U1BA 2GG2A 1KQ0A 4JUQA 1WL6A 2GGCA 1YW7A 2GU6A 4IF7A 2G6PA 1C22A 2BHDA 2GU7A 4OOKA 4KM3A 5CLSA 4IPAA 2OAZA 1Y1NA 2P9AA 4U70A 5CDLA 4FLKA 3L24A 3PKEA 4S2RP 4RZYA 4PNCA 4FO7A 5FCHA 2GU4A 3MX6A 1C27A 2BWVA 5JI6A 4FLIA 2GGBA 1WLRA 2ADUA 3S6BA 3Q6DA 3PKBA 3CB5A 4PV4A 3RVAA 3TAVA 3BIPA 1B6AA 2B3KA 1WBQA 2GTXA 2GG5A 4U76A 3IU7A 1KP0A 4B28A 2V3YA 2Q8KA 2EVMA 2P99A 4FKCA 2BWUA 4S01A 4U69A 4U6WA 4IKTA 2GA2A 2BHAA 2V3ZA 1B59A 2EA2A 2EVCA 5CIKA 2MATA 2BWTA 1BOAA 2NQ6A 4IECA 4ZWPA 1W7VA 1XGOA 2GU5A 1XGSA 2Q92A 4FO8A 4A6VA 2OKNA 5CDVA 3TB5A 3FM3A 4IKUA 4S2TP 4U6EA 4ZNGA 4IKSA 5CNXA 4EGEA 3BITA 5CDEA 1C21A 1QXYA 2B3LA 2HOWA 4HXXA 4U6JA 1QZYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BN5 A;  4RZZ A;  5D6F A;  3BIQ A;  2Q94 A;  3ROR A;  2Q96 A;  2BB7 A;  1JAW A;  1XNZ A;  2GG3 A;  1PV9 A;  2BN7 A;  5FCF A;  4RGZ 1;  4S00 A;  2NQ7 A;  1M35 A;  1YVM A;  2P98 A;  1N51 A;  3CTZ A;  3L7G A;  4U71 A;  2EA4 A;  2GG7 A;  1R5H A;  1C23 A;  2Q93 A;  1XGM A;  3IU9 A;  1WY2 A;  1C24 A;  1CHM A;  3PKD A;  3PKC A;  3CB6 A;  4MAT A;  4U75 A;  2Q95 A;  2BWS A;  3FMQ A;  3MR1 A;  4R60 A;  2EVO A;  4U73 A;  2DFI A;  2GG0 A;  2BWY A;  5CE6 A;  2BH3 A;  1W2M A;  4ZWU A;  1KQ9 A;  2B3H A;  3IG4 A;  1WKM A;  4FLL A;  1R58 A;  3MAT A;  1YJ3 A;  1R5G A;  4Z7M A;  1O0X A;  1YW9 A;  1XGN A;  2ZSG A;  4QR8 A;  4FUK A;  5JHU A;  4IKR A;  1WL9 A;  3D27 A;  4U6Z A;  3FMR A;  2GZ5 A;  5D6E A;  3IU8 A;  1WN1 A;  2BHC A;  1QXW A;  2GG9 A;  1QXZ A;  4A6W A;  4ZWO A;  1MAT A;  5E5B A;  5JFR A;  2BWX A;  2IW2 A;  4IU6 A;  2GG8 A;  2BHB A;  4IDY A;  2V6C A;  2BWW A;  2V3X A;  4FLJ A;  1YW8 A;  4U6C A;  3PKA A;  1A16 A;  4U1B A;  2GG2 A;  1KQ0 A;  4JUQ A;  1WL6 A;  2GGC A;  1YW7 A;  2GU6 A;  4IF7 A;  2G6P A;  1C22 A;  2BHD A;  2GU7 A;  4OOK A;  4KM3 A;  5CLS A;  4IPA A;  2OAZ A;  1Y1N A;  2P9A A;  4U70 A;  5CDL A;  4FLK A;  3L24 A;  3PKE A;  4S2R P;  4RZY A;  4PNC A;  4FO7 A;  5FCH A;  2GU4 A;  3MX6 A;  1C27 A;  2BWV A;  5JI6 A;  4FLI A;  2GGB A;  1WLR A;  2ADU A;  3S6B A;  3Q6D A;  3PKB A;  3CB5 A;  4PV4 A;  3RVA A;  3TAV A;  3BIP A;  1B6A A;  2B3K A;  1WBQ A;  2GTX A;  2GG5 A;  4U76 A;  3IU7 A;  1KP0 A;  4B28 A;  2V3Y A;  2Q8K A;  2EVM A;  2P99 A;  4FKC A;  2BWU A;  4S01 A;  4U69 A;  4U6W A;  4IKT A;  2GA2 A;  2BHA A;  2V3Z A;  1B59 A;  2EA2 A;  2EVC A;  5CIK A;  2MAT A;  2BWT A;  1BOA A;  2NQ6 A;  4IEC A;  4ZWP A;  1W7V A;  1XGO A;  2GU5 A;  1XGS A;  2Q92 A;  4FO8 A;  4A6V A;  2OKN A;  5CDV A;  3TB5 A;  3FM3 A;  4IKU A;  4S2T P;  4U6E A;  4ZNG A;  4IKS A;  5CNX A;  4EGE A;  3BIT A;  5CDE A;  1C21 A;  1QXY A;  2B3L A;  2HOW A;  4HXX A;  4U6J A;  1QZY A; 
#chains in the Genus database with same CATH topology
 1BN5 A;  4RZZ A;  5D6F A;  3BIQ A;  2Q94 A;  3ROR A;  2Q96 A;  2BB7 A;  1JAW A;  1XNZ A;  2GG3 A;  1PV9 A;  2BN7 A;  5FCF A;  4RGZ 1;  4S00 A;  2NQ7 A;  1M35 A;  1YVM A;  2P98 A;  1N51 A;  3CTZ A;  3L7G A;  4U71 A;  2EA4 A;  2GG7 A;  1R5H A;  1C23 A;  2Q93 A;  1XGM A;  3IU9 A;  1WY2 A;  1C24 A;  1CHM A;  3PKD A;  3PKC A;  3CB6 A;  4MAT A;  4U75 A;  2Q95 A;  2BWS A;  3FMQ A;  3MR1 A;  4R60 A;  2EVO A;  4U73 A;  2DFI A;  2GG0 A;  2BWY A;  5CE6 A;  2BH3 A;  1W2M A;  4ZWU A;  1KQ9 A;  2B3H A;  3IG4 A;  1WKM A;  4FLL A;  1R58 A;  3MAT A;  1YJ3 A;  1R5G A;  4Z7M A;  1O0X A;  1YW9 A;  1XGN A;  2ZSG A;  4QR8 A;  4FUK A;  5JHU A;  4IKR A;  1WL9 A;  3D27 A;  4U6Z A;  3FMR A;  2GZ5 A;  5D6E A;  3IU8 A;  1WN1 A;  2BHC A;  1QXW A;  2GG9 A;  1QXZ A;  4A6W A;  4ZWO A;  1MAT A;  5E5B A;  5JFR A;  2BWX A;  2IW2 A;  4IU6 A;  2GG8 A;  2BHB A;  4IDY A;  2V6C A;  2BWW A;  2V3X A;  4FLJ A;  1YW8 A;  4U6C A;  3PKA A;  1A16 A;  4U1B A;  2GG2 A;  1KQ0 A;  4JUQ A;  1WL6 A;  2GGC A;  1YW7 A;  2GU6 A;  4IF7 A;  2G6P A;  1C22 A;  2BHD A;  2GU7 A;  4OOK A;  4KM3 A;  5CLS A;  4IPA A;  2OAZ A;  1Y1N A;  2P9A A;  4U70 A;  5CDL A;  4FLK A;  3L24 A;  3PKE A;  4S2R P;  4RZY A;  4PNC A;  4FO7 A;  5FCH A;  2GU4 A;  3MX6 A;  1C27 A;  2BWV A;  5JI6 A;  4FLI A;  2GGB A;  1WLR A;  2ADU A;  3S6B A;  3Q6D A;  3PKB A;  3CB5 A;  4PV4 A;  3RVA A;  3TAV A;  3BIP A;  1B6A A;  2B3K A;  1WBQ A;  2GTX A;  2GG5 A;  4U76 A;  3IU7 A;  1KP0 A;  4B28 A;  2V3Y A;  2Q8K A;  2EVM A;  2P99 A;  4FKC A;  2BWU A;  4S01 A;  4U69 A;  4U6W A;  4IKT A;  2GA2 A;  2BHA A;  2V3Z A;  1B59 A;  2EA2 A;  2EVC A;  5CIK A;  2MAT A;  2BWT A;  1BOA A;  2NQ6 A;  4IEC A;  4ZWP A;  1W7V A;  1XGO A;  2GU5 A;  1XGS A;  2Q92 A;  4FO8 A;  4A6V A;  2OKN A;  5CDV A;  3TB5 A;  3FM3 A;  4IKU A;  4S2T P;  4U6E A;  4ZNG A;  4IKS A;  5CNX A;  4EGE A;  3BIT A;  5CDE A;  1C21 A;  1QXY A;  2B3L A;  2HOW A;  4HXX A;  4U6J A;  1QZY A; 
#chains in the Genus database with same CATH homology
 1BN5 A;  4RZZ A;  5D6F A;  3BIQ A;  2Q94 A;  3ROR A;  2Q96 A;  2BB7 A;  1JAW A;  1XNZ A;  2GG3 A;  1PV9 A;  2BN7 A;  5FCF A;  4RGZ 1;  4S00 A;  2NQ7 A;  1M35 A;  1YVM A;  2P98 A;  1N51 A;  3CTZ A;  3L7G A;  4U71 A;  2EA4 A;  2GG7 A;  1R5H A;  1C23 A;  2Q93 A;  1XGM A;  3IU9 A;  1WY2 A;  1C24 A;  1CHM A;  3PKD A;  3PKC A;  3CB6 A;  4MAT A;  4U75 A;  2Q95 A;  2BWS A;  3FMQ A;  3MR1 A;  4R60 A;  2EVO A;  4U73 A;  2DFI A;  2GG0 A;  2BWY A;  5CE6 A;  2BH3 A;  1W2M A;  4ZWU A;  1KQ9 A;  2B3H A;  3IG4 A;  1WKM A;  4FLL A;  1R58 A;  3MAT A;  1YJ3 A;  1R5G A;  4Z7M A;  1O0X A;  1YW9 A;  1XGN A;  2ZSG A;  4QR8 A;  4FUK A;  5JHU A;  4IKR A;  1WL9 A;  3D27 A;  4U6Z A;  3FMR A;  2GZ5 A;  5D6E A;  3IU8 A;  1WN1 A;  2BHC A;  1QXW A;  2GG9 A;  1QXZ A;  4A6W A;  4ZWO A;  1MAT A;  5E5B A;  5JFR A;  2BWX A;  2IW2 A;  4IU6 A;  2GG8 A;  2BHB A;  4IDY A;  2V6C A;  2BWW A;  2V3X A;  4FLJ A;  1YW8 A;  4U6C A;  3PKA A;  1A16 A;  4U1B A;  2GG2 A;  1KQ0 A;  4JUQ A;  1WL6 A;  2GGC A;  1YW7 A;  2GU6 A;  4IF7 A;  2G6P A;  1C22 A;  2BHD A;  2GU7 A;  4OOK A;  4KM3 A;  5CLS A;  4IPA A;  2OAZ A;  1Y1N A;  2P9A A;  4U70 A;  5CDL A;  4FLK A;  3L24 A;  3PKE A;  4S2R P;  4RZY A;  4PNC A;  4FO7 A;  5FCH A;  2GU4 A;  3MX6 A;  1C27 A;  2BWV A;  5JI6 A;  4FLI A;  2GGB A;  1WLR A;  2ADU A;  3S6B A;  3Q6D A;  3PKB A;  3CB5 A;  4PV4 A;  3RVA A;  3TAV A;  3BIP A;  1B6A A;  2B3K A;  1WBQ A;  2GTX A;  2GG5 A;  4U76 A;  3IU7 A;  1KP0 A;  4B28 A;  2V3Y A;  2Q8K A;  2EVM A;  2P99 A;  4FKC A;  2BWU A;  4S01 A;  4U69 A;  4U6W A;  4IKT A;  2GA2 A;  2BHA A;  2V3Z A;  1B59 A;  2EA2 A;  2EVC A;  5CIK A;  2MAT A;  2BWT A;  1BOA A;  2NQ6 A;  4IEC A;  4ZWP A;  1W7V A;  1XGO A;  2GU5 A;  1XGS A;  2Q92 A;  4FO8 A;  4A6V A;  2OKN A;  5CDV A;  3TB5 A;  3FM3 A;  4IKU A;  4S2T P;  4U6E A;  4ZNG A;  4IKS A;  5CNX A;  4EGE A;  3BIT A;  5CDE A;  1C21 A;  1QXY A;  2B3L A;  2HOW A;  4HXX A;  4U6J A;  1QZY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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