1QXZA

Crystal structure of s. aureus methionine aminopeptidase in complex with a ketoheterocycle inhibitor 119
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
249
structure length
249
Chain Sequence
MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of staphylococcusaureus methionine aminopeptidase complexed with keto heterocycle and aminoketone inhibitors reveal the formation of a tetrahedral intermediate.
pubmed doi rcsb
molecule tags Hydrolase
source organism Staphylococcus aureus
molecule keywords methionyl aminopeptidase
total genus 81
structure length 249
sequence length 249
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2003-09-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1qxzA00
1R5GA 2BHCA 2GGBA 2DFIA 2GZ5A 3L7GA 2Q95A 2BWVA 3MR1A 4IPAA 4RGZ1 4S01A 4U6EA 1KQ9A 2G6PA 1A16A 3BITA 3IU9A 4PV4A 4EGEA 2ZSGA 4IECA 2EVMA 1C22A 2B3KA 3TB5A 2BWXA 4FLJA 3IG4A 4U6WA 2EA4A 3FMRA 1BOAA 2GG7A 2HOWA 3TAVA 4IU6A 1C24A 4U6CA 4A6VA 5CNXA 2V3ZA 1WL6A 5CIKA 3RORA 5CDLA 4A6WA 1C27A 2B3LA 4ZWUA 3D27A 2GTXA 2BB7A 3Q6DA 5JHUA 5CDEA 4U70A 1JAWA 2Q96A 5FCFA 2GGCA 5JFRA 2BHBA 4IKUA 1QXWA 2Q8KA 2GG9A 2GU4A 1R58A 2BWWA 3IU7A 3PKAA 4PNCA 3FMQA 5CE6A 2EVOA 4B28A 4S00A 1M35A 1WY2A 5D6EA 5CLSA 5JI6A 4FLIA 1YVMA 1XNZA 1WL9A 2V6CA 1PV9A 4RZZA 1O0XA 2GG3A 2B3HA 4MATA 4U6ZA 3RVAA 2P9AA 2OAZA 3IU8A 1C21A 1WLRA 2Q93A 4IDYA 5FCHA 2GG0A 3CTZA 4IF7A 5D6FA 2V3YA 2GU5A 1B59A 3PKDA 3PKCA 4FO7A 1R5HA 4U75A 2NQ6A 1CHMA 1YW9A 5E5BA 2GG2A 1QXYA 4FKCA 1XGMA 4IKSA 1W2MA 4U69A 3FM3A 3BIQA 2BWSA 3CB5A 1XGNA 2Q94A 1WBQA 4FO8A 1MATA 3CB6A 2BWTA 2EVCA 4HXXA 1C23A 2MATA 4JUQA 2GA2A 4ZNGA 3MX6A 2BHDA 2OKNA 2P99A 4OOKA 4Z7MA 1YW7A 2GU7A 2P98A 4FUKA 4ZWPA 2GG5A 4IKTA 1XGSA 1KP0A 1YJ3A 4U71A 4KM3A 4U73A 1W7VA 1WKMA 4FLLA 4RZYA 1QXZA 2GU6A 2BHAA 3MATA 2V3XA 2BWYA 2BN7A 1KQ0A 1Y1NA 1WN1A 2NQ7A 3L24A 4IKRA 1N51A 1XGOA 2IW2A 1QZYA 3BIPA 4U6JA 3S6BA 2BWUA 1B6AA 1BN5A 1YW8A 3PKBA 2ADUA 4S2RP 4S2TP 2Q92A 3PKEA 4U1BA 4U76A 2BH3A 4ZWOA 5CDVA 4FLKA 4R60A 2EA2A 4QR8A 2GG8A
chains in the Genus database with same CATH superfamily
1R5GA 2BHCA 2GGBA 2DFIA 2GZ5A 3L7GA 2Q95A 2BWVA 3MR1A 4IPAA 4RGZ1 4S01A 4U6EA 1KQ9A 2G6PA 1A16A 3BITA 3IU9A 4PV4A 4EGEA 2ZSGA 4IECA 2EVMA 1C22A 2B3KA 3TB5A 2BWXA 4FLJA 3IG4A 4U6WA 2EA4A 3FMRA 1BOAA 2GG7A 2HOWA 3TAVA 4IU6A 1C24A 4U6CA 4A6VA 5CNXA 2V3ZA 1WL6A 5CIKA 3RORA 5CDLA 4A6WA 1C27A 2B3LA 4ZWUA 3D27A 2GTXA 2BB7A 3Q6DA 5JHUA 5CDEA 4U70A 1JAWA 2Q96A 5FCFA 2GGCA 5JFRA 2BHBA 4IKUA 1QXWA 2Q8KA 2GG9A 2GU4A 1R58A 2BWWA 3IU7A 3PKAA 4PNCA 3FMQA 5CE6A 2EVOA 4B28A 4S00A 1M35A 1WY2A 5D6EA 5CLSA 5JI6A 4FLIA 1YVMA 1XNZA 1WL9A 2V6CA 1PV9A 4RZZA 1O0XA 2GG3A 2B3HA 4MATA 4U6ZA 3RVAA 2P9AA 2OAZA 3IU8A 1C21A 1WLRA 2Q93A 4IDYA 5FCHA 2GG0A 3CTZA 4IF7A 5D6FA 2V3YA 2GU5A 1B59A 3PKDA 3PKCA 4FO7A 1R5HA 4U75A 2NQ6A 1CHMA 1YW9A 5E5BA 2GG2A 1QXYA 4FKCA 1XGMA 4IKSA 1W2MA 4U69A 3FM3A 3BIQA 2BWSA 3CB5A 1XGNA 2Q94A 1WBQA 4FO8A 1MATA 3CB6A 2BWTA 2EVCA 4HXXA 1C23A 2MATA 4JUQA 2GA2A 4ZNGA 3MX6A 2BHDA 2OKNA 2P99A 4OOKA 4Z7MA 1YW7A 2GU7A 2P98A 4FUKA 4ZWPA 2GG5A 4IKTA 1XGSA 1KP0A 1YJ3A 4U71A 4KM3A 4U73A 1W7VA 1WKMA 4FLLA 4RZYA 1QXZA 2GU6A 2BHAA 3MATA 2V3XA 2BWYA 2BN7A 1KQ0A 1Y1NA 1WN1A 2NQ7A 3L24A 4IKRA 1N51A 1XGOA 2IW2A 1QZYA 3BIPA 4U6JA 3S6BA 2BWUA 1B6AA 1BN5A 1YW8A 3PKBA 2ADUA 4S2RP 4S2TP 2Q92A 3PKEA 4U1BA 4U76A 2BH3A 4ZWOA 5CDVA 4FLKA 4R60A 2EA2A 4QR8A 2GG8A
chains in the Genus database with same CATH topology
1R5GA 2BHCA 2GGBA 2DFIA 2GZ5A 3L7GA 2Q95A 2BWVA 3MR1A 4IPAA 4RGZ1 4S01A 4U6EA 1KQ9A 2G6PA 1A16A 3BITA 3IU9A 4PV4A 4EGEA 2ZSGA 4IECA 2EVMA 1C22A 2B3KA 3TB5A 2BWXA 4FLJA 3IG4A 4U6WA 2EA4A 3FMRA 1BOAA 2GG7A 2HOWA 3TAVA 4IU6A 1C24A 4U6CA 4A6VA 5CNXA 2V3ZA 1WL6A 5CIKA 3RORA 5CDLA 4A6WA 1C27A 2B3LA 4ZWUA 3D27A 2GTXA 2BB7A 3Q6DA 5JHUA 5CDEA 4U70A 1JAWA 2Q96A 5FCFA 2GGCA 5JFRA 2BHBA 4IKUA 1QXWA 2Q8KA 2GG9A 2GU4A 1R58A 2BWWA 3IU7A 3PKAA 4PNCA 3FMQA 5CE6A 2EVOA 4B28A 4S00A 1M35A 1WY2A 5D6EA 5CLSA 5JI6A 4FLIA 1YVMA 1XNZA 1WL9A 2V6CA 1PV9A 4RZZA 1O0XA 2GG3A 2B3HA 4MATA 4U6ZA 3RVAA 2P9AA 2OAZA 3IU8A 1C21A 1WLRA 2Q93A 4IDYA 5FCHA 2GG0A 3CTZA 4IF7A 5D6FA 2V3YA 2GU5A 1B59A 3PKDA 3PKCA 4FO7A 1R5HA 4U75A 2NQ6A 1CHMA 1YW9A 5E5BA 2GG2A 1QXYA 4FKCA 1XGMA 4IKSA 1W2MA 4U69A 3FM3A 3BIQA 2BWSA 3CB5A 1XGNA 2Q94A 1WBQA 4FO8A 1MATA 3CB6A 2BWTA 2EVCA 4HXXA 1C23A 2MATA 4JUQA 2GA2A 4ZNGA 3MX6A 2BHDA 2OKNA 2P99A 4OOKA 4Z7MA 1YW7A 2GU7A 2P98A 4FUKA 4ZWPA 2GG5A 4IKTA 1XGSA 1KP0A 1YJ3A 4U71A 4KM3A 4U73A 1W7VA 1WKMA 4FLLA 4RZYA 1QXZA 2GU6A 2BHAA 3MATA 2V3XA 2BWYA 2BN7A 1KQ0A 1Y1NA 1WN1A 2NQ7A 3L24A 4IKRA 1N51A 1XGOA 2IW2A 1QZYA 3BIPA 4U6JA 3S6BA 2BWUA 1B6AA 1BN5A 1YW8A 3PKBA 2ADUA 4S2RP 4S2TP 2Q92A 3PKEA 4U1BA 4U76A 2BH3A 4ZWOA 5CDVA 4FLKA 4R60A 2EA2A 4QR8A 2GG8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R5G A;  2BHC A;  2GGB A;  2DFI A;  2GZ5 A;  3L7G A;  2Q95 A;  2BWV A;  3MR1 A;  4IPA A;  4RGZ 1;  4S01 A;  4U6E A;  1KQ9 A;  2G6P A;  1A16 A;  3BIT A;  3IU9 A;  4PV4 A;  4EGE A;  2ZSG A;  4IEC A;  2EVM A;  1C22 A;  2B3K A;  3TB5 A;  2BWX A;  4FLJ A;  3IG4 A;  4U6W A;  2EA4 A;  3FMR A;  1BOA A;  2GG7 A;  2HOW A;  3TAV A;  4IU6 A;  1C24 A;  4U6C A;  4A6V A;  5CNX A;  2V3Z A;  1WL6 A;  5CIK A;  3ROR A;  5CDL A;  4A6W A;  1C27 A;  2B3L A;  4ZWU A;  3D27 A;  2GTX A;  2BB7 A;  3Q6D A;  5JHU A;  5CDE A;  4U70 A;  1JAW A;  2Q96 A;  5FCF A;  2GGC A;  5JFR A;  2BHB A;  4IKU A;  1QXW A;  2Q8K A;  2GG9 A;  2GU4 A;  1R58 A;  2BWW A;  3IU7 A;  3PKA A;  4PNC A;  3FMQ A;  5CE6 A;  2EVO A;  4B28 A;  4S00 A;  1M35 A;  1WY2 A;  5D6E A;  5CLS A;  5JI6 A;  4FLI A;  1YVM A;  1XNZ A;  1WL9 A;  2V6C A;  1PV9 A;  4RZZ A;  1O0X A;  2GG3 A;  2B3H A;  4MAT A;  4U6Z A;  3RVA A;  2P9A A;  2OAZ A;  3IU8 A;  1C21 A;  1WLR A;  2Q93 A;  4IDY A;  5FCH A;  2GG0 A;  3CTZ A;  4IF7 A;  5D6F A;  2V3Y A;  2GU5 A;  1B59 A;  3PKD A;  3PKC A;  4FO7 A;  1R5H A;  4U75 A;  2NQ6 A;  1CHM A;  1YW9 A;  5E5B A;  2GG2 A;  1QXY A;  4FKC A;  1XGM A;  4IKS A;  1W2M A;  4U69 A;  3FM3 A;  3BIQ A;  2BWS A;  3CB5 A;  1XGN A;  2Q94 A;  1WBQ A;  4FO8 A;  1MAT A;  3CB6 A;  2BWT A;  2EVC A;  4HXX A;  1C23 A;  2MAT A;  4JUQ A;  2GA2 A;  4ZNG A;  3MX6 A;  2BHD A;  2OKN A;  2P99 A;  4OOK A;  4Z7M A;  1YW7 A;  2GU7 A;  2P98 A;  4FUK A;  4ZWP A;  2GG5 A;  4IKT A;  1XGS A;  1KP0 A;  1YJ3 A;  4U71 A;  4KM3 A;  4U73 A;  1W7V A;  1WKM A;  4FLL A;  4RZY A;  1QXZ A;  2GU6 A;  2BHA A;  3MAT A;  2V3X A;  2BWY A;  2BN7 A;  1KQ0 A;  1Y1N A;  1WN1 A;  2NQ7 A;  3L24 A;  4IKR A;  1N51 A;  1XGO A;  2IW2 A;  1QZY A;  3BIP A;  4U6J A;  3S6B A;  2BWU A;  1B6A A;  1BN5 A;  1YW8 A;  3PKB A;  2ADU A;  4S2R P;  4S2T P;  2Q92 A;  3PKE A;  4U1B A;  4U76 A;  2BH3 A;  4ZWO A;  5CDV A;  4FLK A;  4R60 A;  2EA2 A;  4QR8 A;  2GG8 A; 
#chains in the Genus database with same CATH topology
 1R5G A;  2BHC A;  2GGB A;  2DFI A;  2GZ5 A;  3L7G A;  2Q95 A;  2BWV A;  3MR1 A;  4IPA A;  4RGZ 1;  4S01 A;  4U6E A;  1KQ9 A;  2G6P A;  1A16 A;  3BIT A;  3IU9 A;  4PV4 A;  4EGE A;  2ZSG A;  4IEC A;  2EVM A;  1C22 A;  2B3K A;  3TB5 A;  2BWX A;  4FLJ A;  3IG4 A;  4U6W A;  2EA4 A;  3FMR A;  1BOA A;  2GG7 A;  2HOW A;  3TAV A;  4IU6 A;  1C24 A;  4U6C A;  4A6V A;  5CNX A;  2V3Z A;  1WL6 A;  5CIK A;  3ROR A;  5CDL A;  4A6W A;  1C27 A;  2B3L A;  4ZWU A;  3D27 A;  2GTX A;  2BB7 A;  3Q6D A;  5JHU A;  5CDE A;  4U70 A;  1JAW A;  2Q96 A;  5FCF A;  2GGC A;  5JFR A;  2BHB A;  4IKU A;  1QXW A;  2Q8K A;  2GG9 A;  2GU4 A;  1R58 A;  2BWW A;  3IU7 A;  3PKA A;  4PNC A;  3FMQ A;  5CE6 A;  2EVO A;  4B28 A;  4S00 A;  1M35 A;  1WY2 A;  5D6E A;  5CLS A;  5JI6 A;  4FLI A;  1YVM A;  1XNZ A;  1WL9 A;  2V6C A;  1PV9 A;  4RZZ A;  1O0X A;  2GG3 A;  2B3H A;  4MAT A;  4U6Z A;  3RVA A;  2P9A A;  2OAZ A;  3IU8 A;  1C21 A;  1WLR A;  2Q93 A;  4IDY A;  5FCH A;  2GG0 A;  3CTZ A;  4IF7 A;  5D6F A;  2V3Y A;  2GU5 A;  1B59 A;  3PKD A;  3PKC A;  4FO7 A;  1R5H A;  4U75 A;  2NQ6 A;  1CHM A;  1YW9 A;  5E5B A;  2GG2 A;  1QXY A;  4FKC A;  1XGM A;  4IKS A;  1W2M A;  4U69 A;  3FM3 A;  3BIQ A;  2BWS A;  3CB5 A;  1XGN A;  2Q94 A;  1WBQ A;  4FO8 A;  1MAT A;  3CB6 A;  2BWT A;  2EVC A;  4HXX A;  1C23 A;  2MAT A;  4JUQ A;  2GA2 A;  4ZNG A;  3MX6 A;  2BHD A;  2OKN A;  2P99 A;  4OOK A;  4Z7M A;  1YW7 A;  2GU7 A;  2P98 A;  4FUK A;  4ZWP A;  2GG5 A;  4IKT A;  1XGS A;  1KP0 A;  1YJ3 A;  4U71 A;  4KM3 A;  4U73 A;  1W7V A;  1WKM A;  4FLL A;  4RZY A;  1QXZ A;  2GU6 A;  2BHA A;  3MAT A;  2V3X A;  2BWY A;  2BN7 A;  1KQ0 A;  1Y1N A;  1WN1 A;  2NQ7 A;  3L24 A;  4IKR A;  1N51 A;  1XGO A;  2IW2 A;  1QZY A;  3BIP A;  4U6J A;  3S6B A;  2BWU A;  1B6A A;  1BN5 A;  1YW8 A;  3PKB A;  2ADU A;  4S2R P;  4S2T P;  2Q92 A;  3PKE A;  4U1B A;  4U76 A;  2BH3 A;  4ZWO A;  5CDV A;  4FLK A;  4R60 A;  2EA2 A;  4QR8 A;  2GG8 A; 
#chains in the Genus database with same CATH homology
 1R5G A;  2BHC A;  2GGB A;  2DFI A;  2GZ5 A;  3L7G A;  2Q95 A;  2BWV A;  3MR1 A;  4IPA A;  4RGZ 1;  4S01 A;  4U6E A;  1KQ9 A;  2G6P A;  1A16 A;  3BIT A;  3IU9 A;  4PV4 A;  4EGE A;  2ZSG A;  4IEC A;  2EVM A;  1C22 A;  2B3K A;  3TB5 A;  2BWX A;  4FLJ A;  3IG4 A;  4U6W A;  2EA4 A;  3FMR A;  1BOA A;  2GG7 A;  2HOW A;  3TAV A;  4IU6 A;  1C24 A;  4U6C A;  4A6V A;  5CNX A;  2V3Z A;  1WL6 A;  5CIK A;  3ROR A;  5CDL A;  4A6W A;  1C27 A;  2B3L A;  4ZWU A;  3D27 A;  2GTX A;  2BB7 A;  3Q6D A;  5JHU A;  5CDE A;  4U70 A;  1JAW A;  2Q96 A;  5FCF A;  2GGC A;  5JFR A;  2BHB A;  4IKU A;  1QXW A;  2Q8K A;  2GG9 A;  2GU4 A;  1R58 A;  2BWW A;  3IU7 A;  3PKA A;  4PNC A;  3FMQ A;  5CE6 A;  2EVO A;  4B28 A;  4S00 A;  1M35 A;  1WY2 A;  5D6E A;  5CLS A;  5JI6 A;  4FLI A;  1YVM A;  1XNZ A;  1WL9 A;  2V6C A;  1PV9 A;  4RZZ A;  1O0X A;  2GG3 A;  2B3H A;  4MAT A;  4U6Z A;  3RVA A;  2P9A A;  2OAZ A;  3IU8 A;  1C21 A;  1WLR A;  2Q93 A;  4IDY A;  5FCH A;  2GG0 A;  3CTZ A;  4IF7 A;  5D6F A;  2V3Y A;  2GU5 A;  1B59 A;  3PKD A;  3PKC A;  4FO7 A;  1R5H A;  4U75 A;  2NQ6 A;  1CHM A;  1YW9 A;  5E5B A;  2GG2 A;  1QXY A;  4FKC A;  1XGM A;  4IKS A;  1W2M A;  4U69 A;  3FM3 A;  3BIQ A;  2BWS A;  3CB5 A;  1XGN A;  2Q94 A;  1WBQ A;  4FO8 A;  1MAT A;  3CB6 A;  2BWT A;  2EVC A;  4HXX A;  1C23 A;  2MAT A;  4JUQ A;  2GA2 A;  4ZNG A;  3MX6 A;  2BHD A;  2OKN A;  2P99 A;  4OOK A;  4Z7M A;  1YW7 A;  2GU7 A;  2P98 A;  4FUK A;  4ZWP A;  2GG5 A;  4IKT A;  1XGS A;  1KP0 A;  1YJ3 A;  4U71 A;  4KM3 A;  4U73 A;  1W7V A;  1WKM A;  4FLL A;  4RZY A;  1QXZ A;  2GU6 A;  2BHA A;  3MAT A;  2V3X A;  2BWY A;  2BN7 A;  1KQ0 A;  1Y1N A;  1WN1 A;  2NQ7 A;  3L24 A;  4IKR A;  1N51 A;  1XGO A;  2IW2 A;  1QZY A;  3BIP A;  4U6J A;  3S6B A;  2BWU A;  1B6A A;  1BN5 A;  1YW8 A;  3PKB A;  2ADU A;  4S2R P;  4S2T P;  2Q92 A;  3PKE A;  4U1B A;  4U76 A;  2BH3 A;  4ZWO A;  5CDV A;  4FLK A;  4R60 A;  2EA2 A;  4QR8 A;  2GG8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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