1XNZA

Crystal structure of mn(ii) form of e. coli. methionine aminopeptidase in complex with 5-(2-chlorophenyl)furan-2-carboxylic acid
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Metalloform-Selective Inhibitors of Escherichia coli Methionine Aminopeptidase and X-ray Structure of a Mn(II)-Form Enzyme Complexed with an Inhibitor.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Escherichia coli
total genus 90
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2004-10-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1xnzA00
1JAWA 5CDEA 4IKRA 2V3ZA 1XGOA 2BN7A 2IW2A 2Q8KA 1A16A 1N51A 4U6JA 4S2RP 5FCHA 1C22A 1B59A 1PV9A 4S01A 3CTZA 2BH3A 2GG3A 4FLJA 4A6VA 2DFIA 1R5GA 1YW7A 4RZYA 1O0XA 2B3HA 1KP0A 3PKCA 1C27A 4HXXA 3IU8A 5E5BA 2GU6A 4IKTA 4IPAA 2BWTA 2GTXA 4IKUA 4QR8A 4KM3A 1QXWA 4RZZA 4EGEA 2EA4A 2GZ5A 3PKBA 1W7VA 2BHBA 2V3XA 5CLSA 3S6BA 4U70A 1MATA 2GGCA 5CIKA 5JHUA 4U76A 2P9AA 4OOKA 2GG8A 2BWYA 1WL6A 4IKSA 2MATA 2BWVA 1R58A 1WKMA 4ZWUA 2OKNA 4R60A 2Q95A 4PNCA 1WLRA 5JI6A 2P99A 2V6CA 4FLIA 1WBQA 4IECA 1WY2A 4U71A 3RVAA 1YW9A 2GG5A 4IU6A 1M35A 2ZSGA 2BWXA 4IF7A 2GG2A 5CE6A 5D6EA 2B3KA 5CDLA 1XGSA 2Q96A 3BIQA 4ZWPA 1C23A 5CDVA 4U1BA 5JFRA 2G6PA 4U6ZA 4FUKA 2EVOA 2Q93A 1C21A 4B28A 2Q94A 2GG7A 4U73A 2GG9A 2BWSA 3PKDA 4U6WA 4IDYA 2ADUA 1KQ9A 1C24A 2OAZA 4FLLA 2BHAA 4FO8A 5CNXA 4FO7A 2HOWA 1YJ3A 4ZNGA 3Q6DA 1W2MA 3PKAA 1XNZA 4Z7MA 2V3YA 1B6AA 1QZYA 3FM3A 3TB5A 2EVCA 1BN5A 2GG0A 2GU7A 1BOAA 4U6CA 3TAVA 3IG4A 4S00A 5FCFA 3D27A 4MATA 1CHMA 1KQ0A 2GGBA 3MX6A 2GA2A 1QXZA 1Y1NA 3BITA 3FMQA 4U69A 4PV4A 1WN1A 2EA2A 2P98A 4U6EA 2GU4A 2GU5A 2NQ7A 1R5HA 3L24A 4FLKA 3FMRA 4A6WA 2BB7A 1QXYA 2EVMA 3CB5A 3IU9A 4ZWOA 4FKCA 2BHDA 5D6FA 2Q92A 2NQ6A 2BHCA 1XGMA 1XGNA 2B3LA 4S2TP 3RORA 1YVMA 2BWWA 2BWUA 3MR1A 4RGZ1 1WL9A 3PKEA 3BIPA 3L7GA 3IU7A 3CB6A 4JUQA 4U75A 1YW8A 3MATA
chains in the Genus database with same CATH superfamily
1JAWA 5CDEA 4IKRA 2V3ZA 1XGOA 2BN7A 2IW2A 2Q8KA 1A16A 1N51A 4U6JA 4S2RP 5FCHA 1C22A 1B59A 1PV9A 4S01A 3CTZA 2BH3A 2GG3A 4FLJA 4A6VA 2DFIA 1R5GA 1YW7A 4RZYA 1O0XA 2B3HA 1KP0A 3PKCA 1C27A 4HXXA 3IU8A 5E5BA 2GU6A 4IKTA 4IPAA 2BWTA 2GTXA 4IKUA 4QR8A 4KM3A 1QXWA 4RZZA 4EGEA 2EA4A 2GZ5A 3PKBA 1W7VA 2BHBA 2V3XA 5CLSA 3S6BA 4U70A 1MATA 2GGCA 5CIKA 5JHUA 4U76A 2P9AA 4OOKA 2GG8A 2BWYA 1WL6A 4IKSA 2MATA 2BWVA 1R58A 1WKMA 4ZWUA 2OKNA 4R60A 2Q95A 4PNCA 1WLRA 5JI6A 2P99A 2V6CA 4FLIA 1WBQA 4IECA 1WY2A 4U71A 3RVAA 1YW9A 2GG5A 4IU6A 1M35A 2ZSGA 2BWXA 4IF7A 2GG2A 5CE6A 5D6EA 2B3KA 5CDLA 1XGSA 2Q96A 3BIQA 4ZWPA 1C23A 5CDVA 4U1BA 5JFRA 2G6PA 4U6ZA 4FUKA 2EVOA 2Q93A 1C21A 4B28A 2Q94A 2GG7A 4U73A 2GG9A 2BWSA 3PKDA 4U6WA 4IDYA 2ADUA 1KQ9A 1C24A 2OAZA 4FLLA 2BHAA 4FO8A 5CNXA 4FO7A 2HOWA 1YJ3A 4ZNGA 3Q6DA 1W2MA 3PKAA 1XNZA 4Z7MA 2V3YA 1B6AA 1QZYA 3FM3A 3TB5A 2EVCA 1BN5A 2GG0A 2GU7A 1BOAA 4U6CA 3TAVA 3IG4A 4S00A 5FCFA 3D27A 4MATA 1CHMA 1KQ0A 2GGBA 3MX6A 2GA2A 1QXZA 1Y1NA 3BITA 3FMQA 4U69A 4PV4A 1WN1A 2EA2A 2P98A 4U6EA 2GU4A 2GU5A 2NQ7A 1R5HA 3L24A 4FLKA 3FMRA 4A6WA 2BB7A 1QXYA 2EVMA 3CB5A 3IU9A 4ZWOA 4FKCA 2BHDA 5D6FA 2Q92A 2NQ6A 2BHCA 1XGMA 1XGNA 2B3LA 4S2TP 3RORA 1YVMA 2BWWA 2BWUA 3MR1A 4RGZ1 1WL9A 3PKEA 3BIPA 3L7GA 3IU7A 3CB6A 4JUQA 4U75A 1YW8A 3MATA
chains in the Genus database with same CATH topology
1JAWA 5CDEA 4IKRA 2V3ZA 1XGOA 2BN7A 2IW2A 2Q8KA 1A16A 1N51A 4U6JA 4S2RP 5FCHA 1C22A 1B59A 1PV9A 4S01A 3CTZA 2BH3A 2GG3A 4FLJA 4A6VA 2DFIA 1R5GA 1YW7A 4RZYA 1O0XA 2B3HA 1KP0A 3PKCA 1C27A 4HXXA 3IU8A 5E5BA 2GU6A 4IKTA 4IPAA 2BWTA 2GTXA 4IKUA 4QR8A 4KM3A 1QXWA 4RZZA 4EGEA 2EA4A 2GZ5A 3PKBA 1W7VA 2BHBA 2V3XA 5CLSA 3S6BA 4U70A 1MATA 2GGCA 5CIKA 5JHUA 4U76A 2P9AA 4OOKA 2GG8A 2BWYA 1WL6A 4IKSA 2MATA 2BWVA 1R58A 1WKMA 4ZWUA 2OKNA 4R60A 2Q95A 4PNCA 1WLRA 5JI6A 2P99A 2V6CA 4FLIA 1WBQA 4IECA 1WY2A 4U71A 3RVAA 1YW9A 2GG5A 4IU6A 1M35A 2ZSGA 2BWXA 4IF7A 2GG2A 5CE6A 5D6EA 2B3KA 5CDLA 1XGSA 2Q96A 3BIQA 4ZWPA 1C23A 5CDVA 4U1BA 5JFRA 2G6PA 4U6ZA 4FUKA 2EVOA 2Q93A 1C21A 4B28A 2Q94A 2GG7A 4U73A 2GG9A 2BWSA 3PKDA 4U6WA 4IDYA 2ADUA 1KQ9A 1C24A 2OAZA 4FLLA 2BHAA 4FO8A 5CNXA 4FO7A 2HOWA 1YJ3A 4ZNGA 3Q6DA 1W2MA 3PKAA 1XNZA 4Z7MA 2V3YA 1B6AA 1QZYA 3FM3A 3TB5A 2EVCA 1BN5A 2GG0A 2GU7A 1BOAA 4U6CA 3TAVA 3IG4A 4S00A 5FCFA 3D27A 4MATA 1CHMA 1KQ0A 2GGBA 3MX6A 2GA2A 1QXZA 1Y1NA 3BITA 3FMQA 4U69A 4PV4A 1WN1A 2EA2A 2P98A 4U6EA 2GU4A 2GU5A 2NQ7A 1R5HA 3L24A 4FLKA 3FMRA 4A6WA 2BB7A 1QXYA 2EVMA 3CB5A 3IU9A 4ZWOA 4FKCA 2BHDA 5D6FA 2Q92A 2NQ6A 2BHCA 1XGMA 1XGNA 2B3LA 4S2TP 3RORA 1YVMA 2BWWA 2BWUA 3MR1A 4RGZ1 1WL9A 3PKEA 3BIPA 3L7GA 3IU7A 3CB6A 4JUQA 4U75A 1YW8A 3MATA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1JAW A;  5CDE A;  4IKR A;  2V3Z A;  1XGO A;  2BN7 A;  2IW2 A;  2Q8K A;  1A16 A;  1N51 A;  4U6J A;  4S2R P;  5FCH A;  1C22 A;  1B59 A;  1PV9 A;  4S01 A;  3CTZ A;  2BH3 A;  2GG3 A;  4FLJ A;  4A6V A;  2DFI A;  1R5G A;  1YW7 A;  4RZY A;  1O0X A;  2B3H A;  1KP0 A;  3PKC A;  1C27 A;  4HXX A;  3IU8 A;  5E5B A;  2GU6 A;  4IKT A;  4IPA A;  2BWT A;  2GTX A;  4IKU A;  4QR8 A;  4KM3 A;  1QXW A;  4RZZ A;  4EGE A;  2EA4 A;  2GZ5 A;  3PKB A;  1W7V A;  2BHB A;  2V3X A;  5CLS A;  3S6B A;  4U70 A;  1MAT A;  2GGC A;  5CIK A;  5JHU A;  4U76 A;  2P9A A;  4OOK A;  2GG8 A;  2BWY A;  1WL6 A;  4IKS A;  2MAT A;  2BWV A;  1R58 A;  1WKM A;  4ZWU A;  2OKN A;  4R60 A;  2Q95 A;  4PNC A;  1WLR A;  5JI6 A;  2P99 A;  2V6C A;  4FLI A;  1WBQ A;  4IEC A;  1WY2 A;  4U71 A;  3RVA A;  1YW9 A;  2GG5 A;  4IU6 A;  1M35 A;  2ZSG A;  2BWX A;  4IF7 A;  2GG2 A;  5CE6 A;  5D6E A;  2B3K A;  5CDL A;  1XGS A;  2Q96 A;  3BIQ A;  4ZWP A;  1C23 A;  5CDV A;  4U1B A;  5JFR A;  2G6P A;  4U6Z A;  4FUK A;  2EVO A;  2Q93 A;  1C21 A;  4B28 A;  2Q94 A;  2GG7 A;  4U73 A;  2GG9 A;  2BWS A;  3PKD A;  4U6W A;  4IDY A;  2ADU A;  1KQ9 A;  1C24 A;  2OAZ A;  4FLL A;  2BHA A;  4FO8 A;  5CNX A;  4FO7 A;  2HOW A;  1YJ3 A;  4ZNG A;  3Q6D A;  1W2M A;  3PKA A;  1XNZ A;  4Z7M A;  2V3Y A;  1B6A A;  1QZY A;  3FM3 A;  3TB5 A;  2EVC A;  1BN5 A;  2GG0 A;  2GU7 A;  1BOA A;  4U6C A;  3TAV A;  3IG4 A;  4S00 A;  5FCF A;  3D27 A;  4MAT A;  1CHM A;  1KQ0 A;  2GGB A;  3MX6 A;  2GA2 A;  1QXZ A;  1Y1N A;  3BIT A;  3FMQ A;  4U69 A;  4PV4 A;  1WN1 A;  2EA2 A;  2P98 A;  4U6E A;  2GU4 A;  2GU5 A;  2NQ7 A;  1R5H A;  3L24 A;  4FLK A;  3FMR A;  4A6W A;  2BB7 A;  1QXY A;  2EVM A;  3CB5 A;  3IU9 A;  4ZWO A;  4FKC A;  2BHD A;  5D6F A;  2Q92 A;  2NQ6 A;  2BHC A;  1XGM A;  1XGN A;  2B3L A;  4S2T P;  3ROR A;  1YVM A;  2BWW A;  2BWU A;  3MR1 A;  4RGZ 1;  1WL9 A;  3PKE A;  3BIP A;  3L7G A;  3IU7 A;  3CB6 A;  4JUQ A;  4U75 A;  1YW8 A;  3MAT A; 
#chains in the Genus database with same CATH topology
 1JAW A;  5CDE A;  4IKR A;  2V3Z A;  1XGO A;  2BN7 A;  2IW2 A;  2Q8K A;  1A16 A;  1N51 A;  4U6J A;  4S2R P;  5FCH A;  1C22 A;  1B59 A;  1PV9 A;  4S01 A;  3CTZ A;  2BH3 A;  2GG3 A;  4FLJ A;  4A6V A;  2DFI A;  1R5G A;  1YW7 A;  4RZY A;  1O0X A;  2B3H A;  1KP0 A;  3PKC A;  1C27 A;  4HXX A;  3IU8 A;  5E5B A;  2GU6 A;  4IKT A;  4IPA A;  2BWT A;  2GTX A;  4IKU A;  4QR8 A;  4KM3 A;  1QXW A;  4RZZ A;  4EGE A;  2EA4 A;  2GZ5 A;  3PKB A;  1W7V A;  2BHB A;  2V3X A;  5CLS A;  3S6B A;  4U70 A;  1MAT A;  2GGC A;  5CIK A;  5JHU A;  4U76 A;  2P9A A;  4OOK A;  2GG8 A;  2BWY A;  1WL6 A;  4IKS A;  2MAT A;  2BWV A;  1R58 A;  1WKM A;  4ZWU A;  2OKN A;  4R60 A;  2Q95 A;  4PNC A;  1WLR A;  5JI6 A;  2P99 A;  2V6C A;  4FLI A;  1WBQ A;  4IEC A;  1WY2 A;  4U71 A;  3RVA A;  1YW9 A;  2GG5 A;  4IU6 A;  1M35 A;  2ZSG A;  2BWX A;  4IF7 A;  2GG2 A;  5CE6 A;  5D6E A;  2B3K A;  5CDL A;  1XGS A;  2Q96 A;  3BIQ A;  4ZWP A;  1C23 A;  5CDV A;  4U1B A;  5JFR A;  2G6P A;  4U6Z A;  4FUK A;  2EVO A;  2Q93 A;  1C21 A;  4B28 A;  2Q94 A;  2GG7 A;  4U73 A;  2GG9 A;  2BWS A;  3PKD A;  4U6W A;  4IDY A;  2ADU A;  1KQ9 A;  1C24 A;  2OAZ A;  4FLL A;  2BHA A;  4FO8 A;  5CNX A;  4FO7 A;  2HOW A;  1YJ3 A;  4ZNG A;  3Q6D A;  1W2M A;  3PKA A;  1XNZ A;  4Z7M A;  2V3Y A;  1B6A A;  1QZY A;  3FM3 A;  3TB5 A;  2EVC A;  1BN5 A;  2GG0 A;  2GU7 A;  1BOA A;  4U6C A;  3TAV A;  3IG4 A;  4S00 A;  5FCF A;  3D27 A;  4MAT A;  1CHM A;  1KQ0 A;  2GGB A;  3MX6 A;  2GA2 A;  1QXZ A;  1Y1N A;  3BIT A;  3FMQ A;  4U69 A;  4PV4 A;  1WN1 A;  2EA2 A;  2P98 A;  4U6E A;  2GU4 A;  2GU5 A;  2NQ7 A;  1R5H A;  3L24 A;  4FLK A;  3FMR A;  4A6W A;  2BB7 A;  1QXY A;  2EVM A;  3CB5 A;  3IU9 A;  4ZWO A;  4FKC A;  2BHD A;  5D6F A;  2Q92 A;  2NQ6 A;  2BHC A;  1XGM A;  1XGN A;  2B3L A;  4S2T P;  3ROR A;  1YVM A;  2BWW A;  2BWU A;  3MR1 A;  4RGZ 1;  1WL9 A;  3PKE A;  3BIP A;  3L7G A;  3IU7 A;  3CB6 A;  4JUQ A;  4U75 A;  1YW8 A;  3MAT A; 
#chains in the Genus database with same CATH homology
 1JAW A;  5CDE A;  4IKR A;  2V3Z A;  1XGO A;  2BN7 A;  2IW2 A;  2Q8K A;  1A16 A;  1N51 A;  4U6J A;  4S2R P;  5FCH A;  1C22 A;  1B59 A;  1PV9 A;  4S01 A;  3CTZ A;  2BH3 A;  2GG3 A;  4FLJ A;  4A6V A;  2DFI A;  1R5G A;  1YW7 A;  4RZY A;  1O0X A;  2B3H A;  1KP0 A;  3PKC A;  1C27 A;  4HXX A;  3IU8 A;  5E5B A;  2GU6 A;  4IKT A;  4IPA A;  2BWT A;  2GTX A;  4IKU A;  4QR8 A;  4KM3 A;  1QXW A;  4RZZ A;  4EGE A;  2EA4 A;  2GZ5 A;  3PKB A;  1W7V A;  2BHB A;  2V3X A;  5CLS A;  3S6B A;  4U70 A;  1MAT A;  2GGC A;  5CIK A;  5JHU A;  4U76 A;  2P9A A;  4OOK A;  2GG8 A;  2BWY A;  1WL6 A;  4IKS A;  2MAT A;  2BWV A;  1R58 A;  1WKM A;  4ZWU A;  2OKN A;  4R60 A;  2Q95 A;  4PNC A;  1WLR A;  5JI6 A;  2P99 A;  2V6C A;  4FLI A;  1WBQ A;  4IEC A;  1WY2 A;  4U71 A;  3RVA A;  1YW9 A;  2GG5 A;  4IU6 A;  1M35 A;  2ZSG A;  2BWX A;  4IF7 A;  2GG2 A;  5CE6 A;  5D6E A;  2B3K A;  5CDL A;  1XGS A;  2Q96 A;  3BIQ A;  4ZWP A;  1C23 A;  5CDV A;  4U1B A;  5JFR A;  2G6P A;  4U6Z A;  4FUK A;  2EVO A;  2Q93 A;  1C21 A;  4B28 A;  2Q94 A;  2GG7 A;  4U73 A;  2GG9 A;  2BWS A;  3PKD A;  4U6W A;  4IDY A;  2ADU A;  1KQ9 A;  1C24 A;  2OAZ A;  4FLL A;  2BHA A;  4FO8 A;  5CNX A;  4FO7 A;  2HOW A;  1YJ3 A;  4ZNG A;  3Q6D A;  1W2M A;  3PKA A;  1XNZ A;  4Z7M A;  2V3Y A;  1B6A A;  1QZY A;  3FM3 A;  3TB5 A;  2EVC A;  1BN5 A;  2GG0 A;  2GU7 A;  1BOA A;  4U6C A;  3TAV A;  3IG4 A;  4S00 A;  5FCF A;  3D27 A;  4MAT A;  1CHM A;  1KQ0 A;  2GGB A;  3MX6 A;  2GA2 A;  1QXZ A;  1Y1N A;  3BIT A;  3FMQ A;  4U69 A;  4PV4 A;  1WN1 A;  2EA2 A;  2P98 A;  4U6E A;  2GU4 A;  2GU5 A;  2NQ7 A;  1R5H A;  3L24 A;  4FLK A;  3FMR A;  4A6W A;  2BB7 A;  1QXY A;  2EVM A;  3CB5 A;  3IU9 A;  4ZWO A;  4FKC A;  2BHD A;  5D6F A;  2Q92 A;  2NQ6 A;  2BHC A;  1XGM A;  1XGN A;  2B3L A;  4S2T P;  3ROR A;  1YVM A;  2BWW A;  2BWU A;  3MR1 A;  4RGZ 1;  1WL9 A;  3PKE A;  3BIP A;  3L7G A;  3IU7 A;  3CB6 A;  4JUQ A;  4U75 A;  1YW8 A;  3MAT A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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