1XNZA

Crystal structure of mn(ii) form of e. coli. methionine aminopeptidase in complex with 5-(2-chlorophenyl)furan-2-carboxylic acid
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Metalloform-Selective Inhibitors of Escherichia coli Methionine Aminopeptidase and X-ray Structure of a Mn(II)-Form Enzyme Complexed with an Inhibitor.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 90
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2004-10-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1xnzA00
4KM3A 1PV9A 2B3LA 1R58A 1WL9A 2BWWA 2GZ5A 1B59A 4U6WA 4U1BA 3TAVA 4FO7A 4FLIA 1O0XA 1C23A 3RVAA 2P99A 2ADUA 4OOKA 1WLRA 2GG9A 5CIKA 3MR1A 1Y1NA 4IKUA 2BHDA 1XGSA 1QXWA 2GGBA 1KP0A 4HXXA 1C21A 2Q92A 2BB7A 2V6CA 2BWUA 2BWYA 5CNXA 2EA2A 3MX6A 2P98A 4U73A 2Q94A 2V3YA 2B3KA 2V3ZA 4S2TP 2BN7A 3PKDA 2DFIA 4FLKA 1QXYA 2BHCA 1MATA 4ZWOA 2BWXA 3CB5A 1JAWA 1KQ9A 1WN1A 1XGNA 4FKCA 1BOAA 3RORA 4U6CA 3BIPA 2GGCA 2OAZA 2GG0A 1KQ0A 3BITA 2EVOA 2P9AA 5CE6A 2Q95A 2GG8A 2OKNA 3D27A 3PKAA 4U6ZA 2EA4A 5JHUA 1BN5A 2GU5A 1YW8A 1WY2A 2EVMA 2GG3A 1C24A 4IDYA 4U75A 1W2MA 2GG7A 5CDVA 2GU4A 4PV4A 3MATA 5FCHA 3CB6A 3PKCA 5E5BA 5CDLA 1XGMA 1W7VA 4EGEA 4IECA 2BWVA 1XGOA 2GU6A 4FO8A 4RZYA 1N51A 4U69A 2Q96A 4A6WA 2BHAA 3PKBA 4U70A 2V3XA 3FMQA 2GG5A 2NQ6A 1R5GA 1YW7A 5CDEA 4Z7MA 4S2RP 1QXZA 3Q6DA 2BHBA 3IU8A 2MATA 4IKTA 5D6EA 1C22A 1R5HA 2GG2A 3L24A 2BH3A 3L7GA 4IKSA 5D6FA 2ZSGA 1WKMA 3FM3A 5CLSA 4FLLA 4U76A 4JUQA 1M35A 5JI6A 2EVCA 3IU7A 4FLJA 4QR8A 4S01A 4IPAA 4ZNGA 1QZYA 2BWSA 2G6PA 4ZWUA 4PNCA 2BWTA 4B28A 4U6JA 1YW9A 3BIQA 3CTZA 4MATA 4R60A 4IF7A 2GTXA 5FCFA 2GA2A 1XNZA 1A16A 1CHMA 4RGZ1 2Q8KA 4U71A 5JFRA 4RZZA 3PKEA 1C27A 1WBQA 2NQ7A 4ZWPA 2HOWA 3FMRA 3TB5A 1YVMA 2GU7A 3IU9A 4A6VA 2Q93A 1B6AA 4IU6A 4FUKA 2B3HA 4S00A 4U6EA 2IW2A 3S6BA 3IG4A 1WL6A 1YJ3A 4IKRA
chains in the Genus database with same CATH superfamily
4KM3A 1PV9A 2B3LA 1R58A 1WL9A 2BWWA 2GZ5A 1B59A 4U6WA 4U1BA 3TAVA 4FO7A 4FLIA 1O0XA 1C23A 3RVAA 2P99A 2ADUA 4OOKA 1WLRA 2GG9A 5CIKA 3MR1A 1Y1NA 4IKUA 2BHDA 1XGSA 1QXWA 2GGBA 1KP0A 4HXXA 1C21A 2Q92A 2BB7A 2V6CA 2BWUA 2BWYA 5CNXA 2EA2A 3MX6A 2P98A 4U73A 2Q94A 2V3YA 2B3KA 2V3ZA 4S2TP 2BN7A 3PKDA 2DFIA 4FLKA 1QXYA 2BHCA 1MATA 4ZWOA 2BWXA 3CB5A 1JAWA 1KQ9A 1WN1A 1XGNA 4FKCA 1BOAA 3RORA 4U6CA 3BIPA 2GGCA 2OAZA 2GG0A 1KQ0A 3BITA 2EVOA 2P9AA 5CE6A 2Q95A 2GG8A 2OKNA 3D27A 3PKAA 4U6ZA 2EA4A 5JHUA 1BN5A 2GU5A 1YW8A 1WY2A 2EVMA 2GG3A 1C24A 4IDYA 4U75A 1W2MA 2GG7A 5CDVA 2GU4A 4PV4A 3MATA 5FCHA 3CB6A 3PKCA 5E5BA 5CDLA 1XGMA 1W7VA 4EGEA 4IECA 2BWVA 1XGOA 2GU6A 4FO8A 4RZYA 1N51A 4U69A 2Q96A 4A6WA 2BHAA 3PKBA 4U70A 2V3XA 3FMQA 2GG5A 2NQ6A 1R5GA 1YW7A 5CDEA 4Z7MA 4S2RP 1QXZA 3Q6DA 2BHBA 3IU8A 2MATA 4IKTA 5D6EA 1C22A 1R5HA 2GG2A 3L24A 2BH3A 3L7GA 4IKSA 5D6FA 2ZSGA 1WKMA 3FM3A 5CLSA 4FLLA 4U76A 4JUQA 1M35A 5JI6A 2EVCA 3IU7A 4FLJA 4QR8A 4S01A 4IPAA 4ZNGA 1QZYA 2BWSA 2G6PA 4ZWUA 4PNCA 2BWTA 4B28A 4U6JA 1YW9A 3BIQA 3CTZA 4MATA 4R60A 4IF7A 2GTXA 5FCFA 2GA2A 1XNZA 1A16A 1CHMA 4RGZ1 2Q8KA 4U71A 5JFRA 4RZZA 3PKEA 1C27A 1WBQA 2NQ7A 4ZWPA 2HOWA 3FMRA 3TB5A 1YVMA 2GU7A 3IU9A 4A6VA 2Q93A 1B6AA 4IU6A 4FUKA 2B3HA 4S00A 4U6EA 2IW2A 3S6BA 3IG4A 1WL6A 1YJ3A 4IKRA
chains in the Genus database with same CATH topology
4KM3A 1PV9A 2B3LA 1R58A 1WL9A 2BWWA 2GZ5A 1B59A 4U6WA 4U1BA 3TAVA 4FO7A 4FLIA 1O0XA 1C23A 3RVAA 2P99A 2ADUA 4OOKA 1WLRA 2GG9A 5CIKA 3MR1A 1Y1NA 4IKUA 2BHDA 1XGSA 1QXWA 2GGBA 1KP0A 4HXXA 1C21A 2Q92A 2BB7A 2V6CA 2BWUA 2BWYA 5CNXA 2EA2A 3MX6A 2P98A 4U73A 2Q94A 2V3YA 2B3KA 2V3ZA 4S2TP 2BN7A 3PKDA 2DFIA 4FLKA 1QXYA 2BHCA 1MATA 4ZWOA 2BWXA 3CB5A 1JAWA 1KQ9A 1WN1A 1XGNA 4FKCA 1BOAA 3RORA 4U6CA 3BIPA 2GGCA 2OAZA 2GG0A 1KQ0A 3BITA 2EVOA 2P9AA 5CE6A 2Q95A 2GG8A 2OKNA 3D27A 3PKAA 4U6ZA 2EA4A 5JHUA 1BN5A 2GU5A 1YW8A 1WY2A 2EVMA 2GG3A 1C24A 4IDYA 4U75A 1W2MA 2GG7A 5CDVA 2GU4A 4PV4A 3MATA 5FCHA 3CB6A 3PKCA 5E5BA 5CDLA 1XGMA 1W7VA 4EGEA 4IECA 2BWVA 1XGOA 2GU6A 4FO8A 4RZYA 1N51A 4U69A 2Q96A 4A6WA 2BHAA 3PKBA 4U70A 2V3XA 3FMQA 2GG5A 2NQ6A 1R5GA 1YW7A 5CDEA 4Z7MA 4S2RP 1QXZA 3Q6DA 2BHBA 3IU8A 2MATA 4IKTA 5D6EA 1C22A 1R5HA 2GG2A 3L24A 2BH3A 3L7GA 4IKSA 5D6FA 2ZSGA 1WKMA 3FM3A 5CLSA 4FLLA 4U76A 4JUQA 1M35A 5JI6A 2EVCA 3IU7A 4FLJA 4QR8A 4S01A 4IPAA 4ZNGA 1QZYA 2BWSA 2G6PA 4ZWUA 4PNCA 2BWTA 4B28A 4U6JA 1YW9A 3BIQA 3CTZA 4MATA 4R60A 4IF7A 2GTXA 5FCFA 2GA2A 1XNZA 1A16A 1CHMA 4RGZ1 2Q8KA 4U71A 5JFRA 4RZZA 3PKEA 1C27A 1WBQA 2NQ7A 4ZWPA 2HOWA 3FMRA 3TB5A 1YVMA 2GU7A 3IU9A 4A6VA 2Q93A 1B6AA 4IU6A 4FUKA 2B3HA 4S00A 4U6EA 2IW2A 3S6BA 3IG4A 1WL6A 1YJ3A 4IKRA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4KM3 A;  1PV9 A;  2B3L A;  1R58 A;  1WL9 A;  2BWW A;  2GZ5 A;  1B59 A;  4U6W A;  4U1B A;  3TAV A;  4FO7 A;  4FLI A;  1O0X A;  1C23 A;  3RVA A;  2P99 A;  2ADU A;  4OOK A;  1WLR A;  2GG9 A;  5CIK A;  3MR1 A;  1Y1N A;  4IKU A;  2BHD A;  1XGS A;  1QXW A;  2GGB A;  1KP0 A;  4HXX A;  1C21 A;  2Q92 A;  2BB7 A;  2V6C A;  2BWU A;  2BWY A;  5CNX A;  2EA2 A;  3MX6 A;  2P98 A;  4U73 A;  2Q94 A;  2V3Y A;  2B3K A;  2V3Z A;  4S2T P;  2BN7 A;  3PKD A;  2DFI A;  4FLK A;  1QXY A;  2BHC A;  1MAT A;  4ZWO A;  2BWX A;  3CB5 A;  1JAW A;  1KQ9 A;  1WN1 A;  1XGN A;  4FKC A;  1BOA A;  3ROR A;  4U6C A;  3BIP A;  2GGC A;  2OAZ A;  2GG0 A;  1KQ0 A;  3BIT A;  2EVO A;  2P9A A;  5CE6 A;  2Q95 A;  2GG8 A;  2OKN A;  3D27 A;  3PKA A;  4U6Z A;  2EA4 A;  5JHU A;  1BN5 A;  2GU5 A;  1YW8 A;  1WY2 A;  2EVM A;  2GG3 A;  1C24 A;  4IDY A;  4U75 A;  1W2M A;  2GG7 A;  5CDV A;  2GU4 A;  4PV4 A;  3MAT A;  5FCH A;  3CB6 A;  3PKC A;  5E5B A;  5CDL A;  1XGM A;  1W7V A;  4EGE A;  4IEC A;  2BWV A;  1XGO A;  2GU6 A;  4FO8 A;  4RZY A;  1N51 A;  4U69 A;  2Q96 A;  4A6W A;  2BHA A;  3PKB A;  4U70 A;  2V3X A;  3FMQ A;  2GG5 A;  2NQ6 A;  1R5G A;  1YW7 A;  5CDE A;  4Z7M A;  4S2R P;  1QXZ A;  3Q6D A;  2BHB A;  3IU8 A;  2MAT A;  4IKT A;  5D6E A;  1C22 A;  1R5H A;  2GG2 A;  3L24 A;  2BH3 A;  3L7G A;  4IKS A;  5D6F A;  2ZSG A;  1WKM A;  3FM3 A;  5CLS A;  4FLL A;  4U76 A;  4JUQ A;  1M35 A;  5JI6 A;  2EVC A;  3IU7 A;  4FLJ A;  4QR8 A;  4S01 A;  4IPA A;  4ZNG A;  1QZY A;  2BWS A;  2G6P A;  4ZWU A;  4PNC A;  2BWT A;  4B28 A;  4U6J A;  1YW9 A;  3BIQ A;  3CTZ A;  4MAT A;  4R60 A;  4IF7 A;  2GTX A;  5FCF A;  2GA2 A;  1XNZ A;  1A16 A;  1CHM A;  4RGZ 1;  2Q8K A;  4U71 A;  5JFR A;  4RZZ A;  3PKE A;  1C27 A;  1WBQ A;  2NQ7 A;  4ZWP A;  2HOW A;  3FMR A;  3TB5 A;  1YVM A;  2GU7 A;  3IU9 A;  4A6V A;  2Q93 A;  1B6A A;  4IU6 A;  4FUK A;  2B3H A;  4S00 A;  4U6E A;  2IW2 A;  3S6B A;  3IG4 A;  1WL6 A;  1YJ3 A;  4IKR A; 
#chains in the Genus database with same CATH topology
 4KM3 A;  1PV9 A;  2B3L A;  1R58 A;  1WL9 A;  2BWW A;  2GZ5 A;  1B59 A;  4U6W A;  4U1B A;  3TAV A;  4FO7 A;  4FLI A;  1O0X A;  1C23 A;  3RVA A;  2P99 A;  2ADU A;  4OOK A;  1WLR A;  2GG9 A;  5CIK A;  3MR1 A;  1Y1N A;  4IKU A;  2BHD A;  1XGS A;  1QXW A;  2GGB A;  1KP0 A;  4HXX A;  1C21 A;  2Q92 A;  2BB7 A;  2V6C A;  2BWU A;  2BWY A;  5CNX A;  2EA2 A;  3MX6 A;  2P98 A;  4U73 A;  2Q94 A;  2V3Y A;  2B3K A;  2V3Z A;  4S2T P;  2BN7 A;  3PKD A;  2DFI A;  4FLK A;  1QXY A;  2BHC A;  1MAT A;  4ZWO A;  2BWX A;  3CB5 A;  1JAW A;  1KQ9 A;  1WN1 A;  1XGN A;  4FKC A;  1BOA A;  3ROR A;  4U6C A;  3BIP A;  2GGC A;  2OAZ A;  2GG0 A;  1KQ0 A;  3BIT A;  2EVO A;  2P9A A;  5CE6 A;  2Q95 A;  2GG8 A;  2OKN A;  3D27 A;  3PKA A;  4U6Z A;  2EA4 A;  5JHU A;  1BN5 A;  2GU5 A;  1YW8 A;  1WY2 A;  2EVM A;  2GG3 A;  1C24 A;  4IDY A;  4U75 A;  1W2M A;  2GG7 A;  5CDV A;  2GU4 A;  4PV4 A;  3MAT A;  5FCH A;  3CB6 A;  3PKC A;  5E5B A;  5CDL A;  1XGM A;  1W7V A;  4EGE A;  4IEC A;  2BWV A;  1XGO A;  2GU6 A;  4FO8 A;  4RZY A;  1N51 A;  4U69 A;  2Q96 A;  4A6W A;  2BHA A;  3PKB A;  4U70 A;  2V3X A;  3FMQ A;  2GG5 A;  2NQ6 A;  1R5G A;  1YW7 A;  5CDE A;  4Z7M A;  4S2R P;  1QXZ A;  3Q6D A;  2BHB A;  3IU8 A;  2MAT A;  4IKT A;  5D6E A;  1C22 A;  1R5H A;  2GG2 A;  3L24 A;  2BH3 A;  3L7G A;  4IKS A;  5D6F A;  2ZSG A;  1WKM A;  3FM3 A;  5CLS A;  4FLL A;  4U76 A;  4JUQ A;  1M35 A;  5JI6 A;  2EVC A;  3IU7 A;  4FLJ A;  4QR8 A;  4S01 A;  4IPA A;  4ZNG A;  1QZY A;  2BWS A;  2G6P A;  4ZWU A;  4PNC A;  2BWT A;  4B28 A;  4U6J A;  1YW9 A;  3BIQ A;  3CTZ A;  4MAT A;  4R60 A;  4IF7 A;  2GTX A;  5FCF A;  2GA2 A;  1XNZ A;  1A16 A;  1CHM A;  4RGZ 1;  2Q8K A;  4U71 A;  5JFR A;  4RZZ A;  3PKE A;  1C27 A;  1WBQ A;  2NQ7 A;  4ZWP A;  2HOW A;  3FMR A;  3TB5 A;  1YVM A;  2GU7 A;  3IU9 A;  4A6V A;  2Q93 A;  1B6A A;  4IU6 A;  4FUK A;  2B3H A;  4S00 A;  4U6E A;  2IW2 A;  3S6B A;  3IG4 A;  1WL6 A;  1YJ3 A;  4IKR A; 
#chains in the Genus database with same CATH homology
 4KM3 A;  1PV9 A;  2B3L A;  1R58 A;  1WL9 A;  2BWW A;  2GZ5 A;  1B59 A;  4U6W A;  4U1B A;  3TAV A;  4FO7 A;  4FLI A;  1O0X A;  1C23 A;  3RVA A;  2P99 A;  2ADU A;  4OOK A;  1WLR A;  2GG9 A;  5CIK A;  3MR1 A;  1Y1N A;  4IKU A;  2BHD A;  1XGS A;  1QXW A;  2GGB A;  1KP0 A;  4HXX A;  1C21 A;  2Q92 A;  2BB7 A;  2V6C A;  2BWU A;  2BWY A;  5CNX A;  2EA2 A;  3MX6 A;  2P98 A;  4U73 A;  2Q94 A;  2V3Y A;  2B3K A;  2V3Z A;  4S2T P;  2BN7 A;  3PKD A;  2DFI A;  4FLK A;  1QXY A;  2BHC A;  1MAT A;  4ZWO A;  2BWX A;  3CB5 A;  1JAW A;  1KQ9 A;  1WN1 A;  1XGN A;  4FKC A;  1BOA A;  3ROR A;  4U6C A;  3BIP A;  2GGC A;  2OAZ A;  2GG0 A;  1KQ0 A;  3BIT A;  2EVO A;  2P9A A;  5CE6 A;  2Q95 A;  2GG8 A;  2OKN A;  3D27 A;  3PKA A;  4U6Z A;  2EA4 A;  5JHU A;  1BN5 A;  2GU5 A;  1YW8 A;  1WY2 A;  2EVM A;  2GG3 A;  1C24 A;  4IDY A;  4U75 A;  1W2M A;  2GG7 A;  5CDV A;  2GU4 A;  4PV4 A;  3MAT A;  5FCH A;  3CB6 A;  3PKC A;  5E5B A;  5CDL A;  1XGM A;  1W7V A;  4EGE A;  4IEC A;  2BWV A;  1XGO A;  2GU6 A;  4FO8 A;  4RZY A;  1N51 A;  4U69 A;  2Q96 A;  4A6W A;  2BHA A;  3PKB A;  4U70 A;  2V3X A;  3FMQ A;  2GG5 A;  2NQ6 A;  1R5G A;  1YW7 A;  5CDE A;  4Z7M A;  4S2R P;  1QXZ A;  3Q6D A;  2BHB A;  3IU8 A;  2MAT A;  4IKT A;  5D6E A;  1C22 A;  1R5H A;  2GG2 A;  3L24 A;  2BH3 A;  3L7G A;  4IKS A;  5D6F A;  2ZSG A;  1WKM A;  3FM3 A;  5CLS A;  4FLL A;  4U76 A;  4JUQ A;  1M35 A;  5JI6 A;  2EVC A;  3IU7 A;  4FLJ A;  4QR8 A;  4S01 A;  4IPA A;  4ZNG A;  1QZY A;  2BWS A;  2G6P A;  4ZWU A;  4PNC A;  2BWT A;  4B28 A;  4U6J A;  1YW9 A;  3BIQ A;  3CTZ A;  4MAT A;  4R60 A;  4IF7 A;  2GTX A;  5FCF A;  2GA2 A;  1XNZ A;  1A16 A;  1CHM A;  4RGZ 1;  2Q8K A;  4U71 A;  5JFR A;  4RZZ A;  3PKE A;  1C27 A;  1WBQ A;  2NQ7 A;  4ZWP A;  2HOW A;  3FMR A;  3TB5 A;  1YVM A;  2GU7 A;  3IU9 A;  4A6V A;  2Q93 A;  1B6A A;  4IU6 A;  4FUK A;  2B3H A;  4S00 A;  4U6E A;  2IW2 A;  3S6B A;  3IG4 A;  1WL6 A;  1YJ3 A;  4IKR A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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