1XNZA

Crystal structure of mn(ii) form of e. coli. methionine aminopeptidase in complex with 5-(2-chlorophenyl)furan-2-carboxylic acid
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Metalloform-Selective Inhibitors of Escherichia coli Methionine Aminopeptidase and X-ray Structure of a Mn(II)-Form Enzyme Complexed with an Inhibitor.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 90
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2004-10-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1xnzA00
3PKEA 2BWVA 4IU6A 1YW7A 1KQ0A 2Q95A 3S6BA 4FO8A 4U6EA 2GU6A 4S2RP 4U71A 2BN7A 3CB5A 2NQ6A 2BWTA 4IF7A 2BHCA 2B3LA 4QR8A 2V3XA 4FLLA 2GU4A 4S00A 3MX6A 1WBQA 3BIPA 1YW8A 3TAVA 2Q93A 1M35A 5E5BA 2GTXA 2GG0A 4S2TP 1N51A 5D6FA 2EA2A 4ZNGA 4U6CA 1QXWA 2EVOA 3PKAA 2BHBA 1XNZA 3L7GA 2GU5A 1WN1A 3FM3A 2BH3A 5CE6A 1XGMA 2BB7A 1O0XA 5JFRA 5JI6A 1W7VA 1WY2A 2OAZA 2P98A 4U6WA 4PNCA 4EGEA 4ZWUA 3PKBA 4A6WA 4KM3A 1WKMA 2B3KA 5CLSA 4R60A 4FUKA 4FLKA 1B59A 4S01A 3IG4A 4IKRA 3TB5A 2Q96A 1BOAA 2DFIA 4FKCA 3L24A 1CHMA 4FLIA 1XGNA 1QXYA 2EVCA 1KP0A 4OOKA 2GG3A 1R5GA 2Q94A 2GG7A 4U73A 2GGBA 4B28A 2P99A 2V6CA 5FCHA 5CDLA 4IDYA 2V3ZA 4IKTA 2V3YA 3D27A 5CDVA 3RVAA 4FLJA 5CNXA 1R58A 2GG5A 4U6JA 1B6AA 1A16A 1WLRA 2P9AA 1QZYA 4U69A 3IU7A 2BHDA 4IECA 1WL6A 2GGCA 2OKNA 3BITA 1C23A 2GA2A 4RZYA 5CDEA 1MATA 2IW2A 1C22A 1C24A 2GG2A 4IKSA 4RGZ1 3FMRA 3RORA 2GG9A 2BWUA 1R5HA 1WL9A 1W2MA 4MATA 5FCFA 1YW9A 4U76A 4U75A 1Y1NA 4RZZA 2Q92A 4IKUA 5CIKA 3BIQA 2EVMA 4A6VA 3MATA 2BWXA 3CB6A 2B3HA 2ZSGA 2NQ7A 1YJ3A 1PV9A 2HOWA 1C27A 2GU7A 4U6ZA 2MATA 3IU9A 1XGSA 3PKCA 4ZWOA 5JHUA 2BWYA 3FMQA 5D6EA 2EA4A 2GZ5A 2BWWA 1BN5A 4U70A 2BWSA 2BHAA 4JUQA 1YVMA 4HXXA 4U1BA 2GG8A 1KQ9A 1XGOA 2G6PA 4ZWPA 1JAWA 4IPAA 2ADUA 3MR1A 1C21A 3PKDA 3IU8A 4FO7A 3Q6DA 4PV4A 2Q8KA 4Z7MA 1QXZA 3CTZA
chains in the Genus database with same CATH superfamily
3PKEA 2BWVA 4IU6A 1YW7A 1KQ0A 2Q95A 3S6BA 4FO8A 4U6EA 2GU6A 4S2RP 4U71A 2BN7A 3CB5A 2NQ6A 2BWTA 4IF7A 2BHCA 2B3LA 4QR8A 2V3XA 4FLLA 2GU4A 4S00A 3MX6A 1WBQA 3BIPA 1YW8A 3TAVA 2Q93A 1M35A 5E5BA 2GTXA 2GG0A 4S2TP 1N51A 5D6FA 2EA2A 4ZNGA 4U6CA 1QXWA 2EVOA 3PKAA 2BHBA 1XNZA 3L7GA 2GU5A 1WN1A 3FM3A 2BH3A 5CE6A 1XGMA 2BB7A 1O0XA 5JFRA 5JI6A 1W7VA 1WY2A 2OAZA 2P98A 4U6WA 4PNCA 4EGEA 4ZWUA 3PKBA 4A6WA 4KM3A 1WKMA 2B3KA 5CLSA 4R60A 4FUKA 4FLKA 1B59A 4S01A 3IG4A 4IKRA 3TB5A 2Q96A 1BOAA 2DFIA 4FKCA 3L24A 1CHMA 4FLIA 1XGNA 1QXYA 2EVCA 1KP0A 4OOKA 2GG3A 1R5GA 2Q94A 2GG7A 4U73A 2GGBA 4B28A 2P99A 2V6CA 5FCHA 5CDLA 4IDYA 2V3ZA 4IKTA 2V3YA 3D27A 5CDVA 3RVAA 4FLJA 5CNXA 1R58A 2GG5A 4U6JA 1B6AA 1A16A 1WLRA 2P9AA 1QZYA 4U69A 3IU7A 2BHDA 4IECA 1WL6A 2GGCA 2OKNA 3BITA 1C23A 2GA2A 4RZYA 5CDEA 1MATA 2IW2A 1C22A 1C24A 2GG2A 4IKSA 4RGZ1 3FMRA 3RORA 2GG9A 2BWUA 1R5HA 1WL9A 1W2MA 4MATA 5FCFA 1YW9A 4U76A 4U75A 1Y1NA 4RZZA 2Q92A 4IKUA 5CIKA 3BIQA 2EVMA 4A6VA 3MATA 2BWXA 3CB6A 2B3HA 2ZSGA 2NQ7A 1YJ3A 1PV9A 2HOWA 1C27A 2GU7A 4U6ZA 2MATA 3IU9A 1XGSA 3PKCA 4ZWOA 5JHUA 2BWYA 3FMQA 5D6EA 2EA4A 2GZ5A 2BWWA 1BN5A 4U70A 2BWSA 2BHAA 4JUQA 1YVMA 4HXXA 4U1BA 2GG8A 1KQ9A 1XGOA 2G6PA 4ZWPA 1JAWA 4IPAA 2ADUA 3MR1A 1C21A 3PKDA 3IU8A 4FO7A 3Q6DA 4PV4A 2Q8KA 4Z7MA 1QXZA 3CTZA
chains in the Genus database with same CATH topology
3PKEA 2BWVA 4IU6A 1YW7A 1KQ0A 2Q95A 3S6BA 4FO8A 4U6EA 2GU6A 4S2RP 4U71A 2BN7A 3CB5A 2NQ6A 2BWTA 4IF7A 2BHCA 2B3LA 4QR8A 2V3XA 4FLLA 2GU4A 4S00A 3MX6A 1WBQA 3BIPA 1YW8A 3TAVA 2Q93A 1M35A 5E5BA 2GTXA 2GG0A 4S2TP 1N51A 5D6FA 2EA2A 4ZNGA 4U6CA 1QXWA 2EVOA 3PKAA 2BHBA 1XNZA 3L7GA 2GU5A 1WN1A 3FM3A 2BH3A 5CE6A 1XGMA 2BB7A 1O0XA 5JFRA 5JI6A 1W7VA 1WY2A 2OAZA 2P98A 4U6WA 4PNCA 4EGEA 4ZWUA 3PKBA 4A6WA 4KM3A 1WKMA 2B3KA 5CLSA 4R60A 4FUKA 4FLKA 1B59A 4S01A 3IG4A 4IKRA 3TB5A 2Q96A 1BOAA 2DFIA 4FKCA 3L24A 1CHMA 4FLIA 1XGNA 1QXYA 2EVCA 1KP0A 4OOKA 2GG3A 1R5GA 2Q94A 2GG7A 4U73A 2GGBA 4B28A 2P99A 2V6CA 5FCHA 5CDLA 4IDYA 2V3ZA 4IKTA 2V3YA 3D27A 5CDVA 3RVAA 4FLJA 5CNXA 1R58A 2GG5A 4U6JA 1B6AA 1A16A 1WLRA 2P9AA 1QZYA 4U69A 3IU7A 2BHDA 4IECA 1WL6A 2GGCA 2OKNA 3BITA 1C23A 2GA2A 4RZYA 5CDEA 1MATA 2IW2A 1C22A 1C24A 2GG2A 4IKSA 4RGZ1 3FMRA 3RORA 2GG9A 2BWUA 1R5HA 1WL9A 1W2MA 4MATA 5FCFA 1YW9A 4U76A 4U75A 1Y1NA 4RZZA 2Q92A 4IKUA 5CIKA 3BIQA 2EVMA 4A6VA 3MATA 2BWXA 3CB6A 2B3HA 2ZSGA 2NQ7A 1YJ3A 1PV9A 2HOWA 1C27A 2GU7A 4U6ZA 2MATA 3IU9A 1XGSA 3PKCA 4ZWOA 5JHUA 2BWYA 3FMQA 5D6EA 2EA4A 2GZ5A 2BWWA 1BN5A 4U70A 2BWSA 2BHAA 4JUQA 1YVMA 4HXXA 4U1BA 2GG8A 1KQ9A 1XGOA 2G6PA 4ZWPA 1JAWA 4IPAA 2ADUA 3MR1A 1C21A 3PKDA 3IU8A 4FO7A 3Q6DA 4PV4A 2Q8KA 4Z7MA 1QXZA 3CTZA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3PKE A;  2BWV A;  4IU6 A;  1YW7 A;  1KQ0 A;  2Q95 A;  3S6B A;  4FO8 A;  4U6E A;  2GU6 A;  4S2R P;  4U71 A;  2BN7 A;  3CB5 A;  2NQ6 A;  2BWT A;  4IF7 A;  2BHC A;  2B3L A;  4QR8 A;  2V3X A;  4FLL A;  2GU4 A;  4S00 A;  3MX6 A;  1WBQ A;  3BIP A;  1YW8 A;  3TAV A;  2Q93 A;  1M35 A;  5E5B A;  2GTX A;  2GG0 A;  4S2T P;  1N51 A;  5D6F A;  2EA2 A;  4ZNG A;  4U6C A;  1QXW A;  2EVO A;  3PKA A;  2BHB A;  1XNZ A;  3L7G A;  2GU5 A;  1WN1 A;  3FM3 A;  2BH3 A;  5CE6 A;  1XGM A;  2BB7 A;  1O0X A;  5JFR A;  5JI6 A;  1W7V A;  1WY2 A;  2OAZ A;  2P98 A;  4U6W A;  4PNC A;  4EGE A;  4ZWU A;  3PKB A;  4A6W A;  4KM3 A;  1WKM A;  2B3K A;  5CLS A;  4R60 A;  4FUK A;  4FLK A;  1B59 A;  4S01 A;  3IG4 A;  4IKR A;  3TB5 A;  2Q96 A;  1BOA A;  2DFI A;  4FKC A;  3L24 A;  1CHM A;  4FLI A;  1XGN A;  1QXY A;  2EVC A;  1KP0 A;  4OOK A;  2GG3 A;  1R5G A;  2Q94 A;  2GG7 A;  4U73 A;  2GGB A;  4B28 A;  2P99 A;  2V6C A;  5FCH A;  5CDL A;  4IDY A;  2V3Z A;  4IKT A;  2V3Y A;  3D27 A;  5CDV A;  3RVA A;  4FLJ A;  5CNX A;  1R58 A;  2GG5 A;  4U6J A;  1B6A A;  1A16 A;  1WLR A;  2P9A A;  1QZY A;  4U69 A;  3IU7 A;  2BHD A;  4IEC A;  1WL6 A;  2GGC A;  2OKN A;  3BIT A;  1C23 A;  2GA2 A;  4RZY A;  5CDE A;  1MAT A;  2IW2 A;  1C22 A;  1C24 A;  2GG2 A;  4IKS A;  4RGZ 1;  3FMR A;  3ROR A;  2GG9 A;  2BWU A;  1R5H A;  1WL9 A;  1W2M A;  4MAT A;  5FCF A;  1YW9 A;  4U76 A;  4U75 A;  1Y1N A;  4RZZ A;  2Q92 A;  4IKU A;  5CIK A;  3BIQ A;  2EVM A;  4A6V A;  3MAT A;  2BWX A;  3CB6 A;  2B3H A;  2ZSG A;  2NQ7 A;  1YJ3 A;  1PV9 A;  2HOW A;  1C27 A;  2GU7 A;  4U6Z A;  2MAT A;  3IU9 A;  1XGS A;  3PKC A;  4ZWO A;  5JHU A;  2BWY A;  3FMQ A;  5D6E A;  2EA4 A;  2GZ5 A;  2BWW A;  1BN5 A;  4U70 A;  2BWS A;  2BHA A;  4JUQ A;  1YVM A;  4HXX A;  4U1B A;  2GG8 A;  1KQ9 A;  1XGO A;  2G6P A;  4ZWP A;  1JAW A;  4IPA A;  2ADU A;  3MR1 A;  1C21 A;  3PKD A;  3IU8 A;  4FO7 A;  3Q6D A;  4PV4 A;  2Q8K A;  4Z7M A;  1QXZ A;  3CTZ A; 
#chains in the Genus database with same CATH topology
 3PKE A;  2BWV A;  4IU6 A;  1YW7 A;  1KQ0 A;  2Q95 A;  3S6B A;  4FO8 A;  4U6E A;  2GU6 A;  4S2R P;  4U71 A;  2BN7 A;  3CB5 A;  2NQ6 A;  2BWT A;  4IF7 A;  2BHC A;  2B3L A;  4QR8 A;  2V3X A;  4FLL A;  2GU4 A;  4S00 A;  3MX6 A;  1WBQ A;  3BIP A;  1YW8 A;  3TAV A;  2Q93 A;  1M35 A;  5E5B A;  2GTX A;  2GG0 A;  4S2T P;  1N51 A;  5D6F A;  2EA2 A;  4ZNG A;  4U6C A;  1QXW A;  2EVO A;  3PKA A;  2BHB A;  1XNZ A;  3L7G A;  2GU5 A;  1WN1 A;  3FM3 A;  2BH3 A;  5CE6 A;  1XGM A;  2BB7 A;  1O0X A;  5JFR A;  5JI6 A;  1W7V A;  1WY2 A;  2OAZ A;  2P98 A;  4U6W A;  4PNC A;  4EGE A;  4ZWU A;  3PKB A;  4A6W A;  4KM3 A;  1WKM A;  2B3K A;  5CLS A;  4R60 A;  4FUK A;  4FLK A;  1B59 A;  4S01 A;  3IG4 A;  4IKR A;  3TB5 A;  2Q96 A;  1BOA A;  2DFI A;  4FKC A;  3L24 A;  1CHM A;  4FLI A;  1XGN A;  1QXY A;  2EVC A;  1KP0 A;  4OOK A;  2GG3 A;  1R5G A;  2Q94 A;  2GG7 A;  4U73 A;  2GGB A;  4B28 A;  2P99 A;  2V6C A;  5FCH A;  5CDL A;  4IDY A;  2V3Z A;  4IKT A;  2V3Y A;  3D27 A;  5CDV A;  3RVA A;  4FLJ A;  5CNX A;  1R58 A;  2GG5 A;  4U6J A;  1B6A A;  1A16 A;  1WLR A;  2P9A A;  1QZY A;  4U69 A;  3IU7 A;  2BHD A;  4IEC A;  1WL6 A;  2GGC A;  2OKN A;  3BIT A;  1C23 A;  2GA2 A;  4RZY A;  5CDE A;  1MAT A;  2IW2 A;  1C22 A;  1C24 A;  2GG2 A;  4IKS A;  4RGZ 1;  3FMR A;  3ROR A;  2GG9 A;  2BWU A;  1R5H A;  1WL9 A;  1W2M A;  4MAT A;  5FCF A;  1YW9 A;  4U76 A;  4U75 A;  1Y1N A;  4RZZ A;  2Q92 A;  4IKU A;  5CIK A;  3BIQ A;  2EVM A;  4A6V A;  3MAT A;  2BWX A;  3CB6 A;  2B3H A;  2ZSG A;  2NQ7 A;  1YJ3 A;  1PV9 A;  2HOW A;  1C27 A;  2GU7 A;  4U6Z A;  2MAT A;  3IU9 A;  1XGS A;  3PKC A;  4ZWO A;  5JHU A;  2BWY A;  3FMQ A;  5D6E A;  2EA4 A;  2GZ5 A;  2BWW A;  1BN5 A;  4U70 A;  2BWS A;  2BHA A;  4JUQ A;  1YVM A;  4HXX A;  4U1B A;  2GG8 A;  1KQ9 A;  1XGO A;  2G6P A;  4ZWP A;  1JAW A;  4IPA A;  2ADU A;  3MR1 A;  1C21 A;  3PKD A;  3IU8 A;  4FO7 A;  3Q6D A;  4PV4 A;  2Q8K A;  4Z7M A;  1QXZ A;  3CTZ A; 
#chains in the Genus database with same CATH homology
 3PKE A;  2BWV A;  4IU6 A;  1YW7 A;  1KQ0 A;  2Q95 A;  3S6B A;  4FO8 A;  4U6E A;  2GU6 A;  4S2R P;  4U71 A;  2BN7 A;  3CB5 A;  2NQ6 A;  2BWT A;  4IF7 A;  2BHC A;  2B3L A;  4QR8 A;  2V3X A;  4FLL A;  2GU4 A;  4S00 A;  3MX6 A;  1WBQ A;  3BIP A;  1YW8 A;  3TAV A;  2Q93 A;  1M35 A;  5E5B A;  2GTX A;  2GG0 A;  4S2T P;  1N51 A;  5D6F A;  2EA2 A;  4ZNG A;  4U6C A;  1QXW A;  2EVO A;  3PKA A;  2BHB A;  1XNZ A;  3L7G A;  2GU5 A;  1WN1 A;  3FM3 A;  2BH3 A;  5CE6 A;  1XGM A;  2BB7 A;  1O0X A;  5JFR A;  5JI6 A;  1W7V A;  1WY2 A;  2OAZ A;  2P98 A;  4U6W A;  4PNC A;  4EGE A;  4ZWU A;  3PKB A;  4A6W A;  4KM3 A;  1WKM A;  2B3K A;  5CLS A;  4R60 A;  4FUK A;  4FLK A;  1B59 A;  4S01 A;  3IG4 A;  4IKR A;  3TB5 A;  2Q96 A;  1BOA A;  2DFI A;  4FKC A;  3L24 A;  1CHM A;  4FLI A;  1XGN A;  1QXY A;  2EVC A;  1KP0 A;  4OOK A;  2GG3 A;  1R5G A;  2Q94 A;  2GG7 A;  4U73 A;  2GGB A;  4B28 A;  2P99 A;  2V6C A;  5FCH A;  5CDL A;  4IDY A;  2V3Z A;  4IKT A;  2V3Y A;  3D27 A;  5CDV A;  3RVA A;  4FLJ A;  5CNX A;  1R58 A;  2GG5 A;  4U6J A;  1B6A A;  1A16 A;  1WLR A;  2P9A A;  1QZY A;  4U69 A;  3IU7 A;  2BHD A;  4IEC A;  1WL6 A;  2GGC A;  2OKN A;  3BIT A;  1C23 A;  2GA2 A;  4RZY A;  5CDE A;  1MAT A;  2IW2 A;  1C22 A;  1C24 A;  2GG2 A;  4IKS A;  4RGZ 1;  3FMR A;  3ROR A;  2GG9 A;  2BWU A;  1R5H A;  1WL9 A;  1W2M A;  4MAT A;  5FCF A;  1YW9 A;  4U76 A;  4U75 A;  1Y1N A;  4RZZ A;  2Q92 A;  4IKU A;  5CIK A;  3BIQ A;  2EVM A;  4A6V A;  3MAT A;  2BWX A;  3CB6 A;  2B3H A;  2ZSG A;  2NQ7 A;  1YJ3 A;  1PV9 A;  2HOW A;  1C27 A;  2GU7 A;  4U6Z A;  2MAT A;  3IU9 A;  1XGS A;  3PKC A;  4ZWO A;  5JHU A;  2BWY A;  3FMQ A;  5D6E A;  2EA4 A;  2GZ5 A;  2BWW A;  1BN5 A;  4U70 A;  2BWS A;  2BHA A;  4JUQ A;  1YVM A;  4HXX A;  4U1B A;  2GG8 A;  1KQ9 A;  1XGO A;  2G6P A;  4ZWP A;  1JAW A;  4IPA A;  2ADU A;  3MR1 A;  1C21 A;  3PKD A;  3IU8 A;  4FO7 A;  3Q6D A;  4PV4 A;  2Q8K A;  4Z7M A;  1QXZ A;  3CTZ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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