1YVMA

E. coli methionine aminopeptidase in complex with thiabendazole
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Metal Ions as Cofactors for the Binding of Inhibitors to Methionine Aminopeptidase: A Critical View of the Relevance of In Vitro Metalloenzyme Assays.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1yvmA00
4PNCA 2OKNA 1YJ3A 2Q95A 4U69A 4A6VA 2BN7A 2BWWA 4U6JA 1YW7A 2EVOA 2EVMA 2V3XA 1C24A 1C22A 3IU8A 2BH3A 2P99A 2ZSGA 3S6BA 1R5GA 2GG8A 1QZYA 2Q93A 2IW2A 2BWSA 3IG4A 2P9AA 4JUQA 4HXXA 4RZYA 2EA4A 4U76A 2BHBA 4OOKA 4RGZ1 1R5HA 1KQ9A 2GU7A 1W2MA 3PKBA 4IPAA 4IECA 5CDLA 4S00A 1Y1NA 3PKDA 1XNZA 4FLKA 1XGMA 4MATA 2GGCA 2Q8KA 2EVCA 2B3HA 3PKAA 1B59A 4U70A 1XGOA 1PV9A 2MATA 4U6ZA 1M35A 4FLJA 2BWUA 1R58A 2OAZA 1C27A 2GG5A 3CB6A 4S2TP 1B6AA 5JI6A 1YW8A 1WKMA 2BB7A 4FLLA 5JHUA 4EGEA 1XGSA 3RORA 3TAVA 2BWXA 4U6WA 1WBQA 1KP0A 2BWVA 2EA2A 2NQ6A 4FUKA 4QR8A 5D6EA 4IF7A 1YW9A 3BITA 3L7GA 4IU6A 3BIPA 4ZWUA 4PV4A 1WL9A 4U71A 4Z7MA 3FM3A 2Q92A 2V3ZA 4ZNGA 1KQ0A 2GG9A 4U75A 5D6FA 5CDEA 2GTXA 2GG0A 3MATA 4ZWPA 1C21A 1BOAA 1WLRA 2V3YA 4FO7A 4RZZA 2P98A 4S01A 5FCHA 4U73A 2DFIA 3IU9A 4R60A 3MR1A 2BWTA 2GU5A 4IKUA 2BHCA 4IKSA 2V6CA 2GU6A 4S2RP 3MX6A 4FLIA 2GGBA 2GA2A 3Q6DA 3FMRA 4U6EA 4IKRA 1CHMA 3CB5A 4FO8A 5CDVA 4ZWOA 1XGNA 3PKEA 2BHAA 4U6CA 2B3KA 5CLSA 2B3LA 2GG3A 1QXYA 5JFRA 2BHDA 2ADUA 4FKCA 1O0XA 4IDYA 3PKCA 2G6PA 2GZ5A 3D27A 3IU7A 1W7VA 2GU4A 3FMQA 5E5BA 1A16A 1JAWA 5CNXA 2Q94A 5FCFA 2GG7A 5CE6A 3CTZA 1WY2A 2GG2A 2HOWA 3TB5A 3L24A 1QXZA 1QXWA 2NQ7A 2Q96A 4U1BA 1C23A 3RVAA 4B28A 1MATA 3BIQA 2BWYA 4IKTA 1WL6A 4A6WA 1N51A 1YVMA 1BN5A 5CIKA 1WN1A 4KM3A
chains in the Genus database with same CATH superfamily
4PNCA 2OKNA 1YJ3A 2Q95A 4U69A 4A6VA 2BN7A 2BWWA 4U6JA 1YW7A 2EVOA 2EVMA 2V3XA 1C24A 1C22A 3IU8A 2BH3A 2P99A 2ZSGA 3S6BA 1R5GA 2GG8A 1QZYA 2Q93A 2IW2A 2BWSA 3IG4A 2P9AA 4JUQA 4HXXA 4RZYA 2EA4A 4U76A 2BHBA 4OOKA 4RGZ1 1R5HA 1KQ9A 2GU7A 1W2MA 3PKBA 4IPAA 4IECA 5CDLA 4S00A 1Y1NA 3PKDA 1XNZA 4FLKA 1XGMA 4MATA 2GGCA 2Q8KA 2EVCA 2B3HA 3PKAA 1B59A 4U70A 1XGOA 1PV9A 2MATA 4U6ZA 1M35A 4FLJA 2BWUA 1R58A 2OAZA 1C27A 2GG5A 3CB6A 4S2TP 1B6AA 5JI6A 1YW8A 1WKMA 2BB7A 4FLLA 5JHUA 4EGEA 1XGSA 3RORA 3TAVA 2BWXA 4U6WA 1WBQA 1KP0A 2BWVA 2EA2A 2NQ6A 4FUKA 4QR8A 5D6EA 4IF7A 1YW9A 3BITA 3L7GA 4IU6A 3BIPA 4ZWUA 4PV4A 1WL9A 4U71A 4Z7MA 3FM3A 2Q92A 2V3ZA 4ZNGA 1KQ0A 2GG9A 4U75A 5D6FA 5CDEA 2GTXA 2GG0A 3MATA 4ZWPA 1C21A 1BOAA 1WLRA 2V3YA 4FO7A 4RZZA 2P98A 4S01A 5FCHA 4U73A 2DFIA 3IU9A 4R60A 3MR1A 2BWTA 2GU5A 4IKUA 2BHCA 4IKSA 2V6CA 2GU6A 4S2RP 3MX6A 4FLIA 2GGBA 2GA2A 3Q6DA 3FMRA 4U6EA 4IKRA 1CHMA 3CB5A 4FO8A 5CDVA 4ZWOA 1XGNA 3PKEA 2BHAA 4U6CA 2B3KA 5CLSA 2B3LA 2GG3A 1QXYA 5JFRA 2BHDA 2ADUA 4FKCA 1O0XA 4IDYA 3PKCA 2G6PA 2GZ5A 3D27A 3IU7A 1W7VA 2GU4A 3FMQA 5E5BA 1A16A 1JAWA 5CNXA 2Q94A 5FCFA 2GG7A 5CE6A 3CTZA 1WY2A 2GG2A 2HOWA 3TB5A 3L24A 1QXZA 1QXWA 2NQ7A 2Q96A 4U1BA 1C23A 3RVAA 4B28A 1MATA 3BIQA 2BWYA 4IKTA 1WL6A 4A6WA 1N51A 1YVMA 1BN5A 5CIKA 1WN1A 4KM3A
chains in the Genus database with same CATH topology
4PNCA 2OKNA 1YJ3A 2Q95A 4U69A 4A6VA 2BN7A 2BWWA 4U6JA 1YW7A 2EVOA 2EVMA 2V3XA 1C24A 1C22A 3IU8A 2BH3A 2P99A 2ZSGA 3S6BA 1R5GA 2GG8A 1QZYA 2Q93A 2IW2A 2BWSA 3IG4A 2P9AA 4JUQA 4HXXA 4RZYA 2EA4A 4U76A 2BHBA 4OOKA 4RGZ1 1R5HA 1KQ9A 2GU7A 1W2MA 3PKBA 4IPAA 4IECA 5CDLA 4S00A 1Y1NA 3PKDA 1XNZA 4FLKA 1XGMA 4MATA 2GGCA 2Q8KA 2EVCA 2B3HA 3PKAA 1B59A 4U70A 1XGOA 1PV9A 2MATA 4U6ZA 1M35A 4FLJA 2BWUA 1R58A 2OAZA 1C27A 2GG5A 3CB6A 4S2TP 1B6AA 5JI6A 1YW8A 1WKMA 2BB7A 4FLLA 5JHUA 4EGEA 1XGSA 3RORA 3TAVA 2BWXA 4U6WA 1WBQA 1KP0A 2BWVA 2EA2A 2NQ6A 4FUKA 4QR8A 5D6EA 4IF7A 1YW9A 3BITA 3L7GA 4IU6A 3BIPA 4ZWUA 4PV4A 1WL9A 4U71A 4Z7MA 3FM3A 2Q92A 2V3ZA 4ZNGA 1KQ0A 2GG9A 4U75A 5D6FA 5CDEA 2GTXA 2GG0A 3MATA 4ZWPA 1C21A 1BOAA 1WLRA 2V3YA 4FO7A 4RZZA 2P98A 4S01A 5FCHA 4U73A 2DFIA 3IU9A 4R60A 3MR1A 2BWTA 2GU5A 4IKUA 2BHCA 4IKSA 2V6CA 2GU6A 4S2RP 3MX6A 4FLIA 2GGBA 2GA2A 3Q6DA 3FMRA 4U6EA 4IKRA 1CHMA 3CB5A 4FO8A 5CDVA 4ZWOA 1XGNA 3PKEA 2BHAA 4U6CA 2B3KA 5CLSA 2B3LA 2GG3A 1QXYA 5JFRA 2BHDA 2ADUA 4FKCA 1O0XA 4IDYA 3PKCA 2G6PA 2GZ5A 3D27A 3IU7A 1W7VA 2GU4A 3FMQA 5E5BA 1A16A 1JAWA 5CNXA 2Q94A 5FCFA 2GG7A 5CE6A 3CTZA 1WY2A 2GG2A 2HOWA 3TB5A 3L24A 1QXZA 1QXWA 2NQ7A 2Q96A 4U1BA 1C23A 3RVAA 4B28A 1MATA 3BIQA 2BWYA 4IKTA 1WL6A 4A6WA 1N51A 1YVMA 1BN5A 5CIKA 1WN1A 4KM3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4PNC A;  2OKN A;  1YJ3 A;  2Q95 A;  4U69 A;  4A6V A;  2BN7 A;  2BWW A;  4U6J A;  1YW7 A;  2EVO A;  2EVM A;  2V3X A;  1C24 A;  1C22 A;  3IU8 A;  2BH3 A;  2P99 A;  2ZSG A;  3S6B A;  1R5G A;  2GG8 A;  1QZY A;  2Q93 A;  2IW2 A;  2BWS A;  3IG4 A;  2P9A A;  4JUQ A;  4HXX A;  4RZY A;  2EA4 A;  4U76 A;  2BHB A;  4OOK A;  4RGZ 1;  1R5H A;  1KQ9 A;  2GU7 A;  1W2M A;  3PKB A;  4IPA A;  4IEC A;  5CDL A;  4S00 A;  1Y1N A;  3PKD A;  1XNZ A;  4FLK A;  1XGM A;  4MAT A;  2GGC A;  2Q8K A;  2EVC A;  2B3H A;  3PKA A;  1B59 A;  4U70 A;  1XGO A;  1PV9 A;  2MAT A;  4U6Z A;  1M35 A;  4FLJ A;  2BWU A;  1R58 A;  2OAZ A;  1C27 A;  2GG5 A;  3CB6 A;  4S2T P;  1B6A A;  5JI6 A;  1YW8 A;  1WKM A;  2BB7 A;  4FLL A;  5JHU A;  4EGE A;  1XGS A;  3ROR A;  3TAV A;  2BWX A;  4U6W A;  1WBQ A;  1KP0 A;  2BWV A;  2EA2 A;  2NQ6 A;  4FUK A;  4QR8 A;  5D6E A;  4IF7 A;  1YW9 A;  3BIT A;  3L7G A;  4IU6 A;  3BIP A;  4ZWU A;  4PV4 A;  1WL9 A;  4U71 A;  4Z7M A;  3FM3 A;  2Q92 A;  2V3Z A;  4ZNG A;  1KQ0 A;  2GG9 A;  4U75 A;  5D6F A;  5CDE A;  2GTX A;  2GG0 A;  3MAT A;  4ZWP A;  1C21 A;  1BOA A;  1WLR A;  2V3Y A;  4FO7 A;  4RZZ A;  2P98 A;  4S01 A;  5FCH A;  4U73 A;  2DFI A;  3IU9 A;  4R60 A;  3MR1 A;  2BWT A;  2GU5 A;  4IKU A;  2BHC A;  4IKS A;  2V6C A;  2GU6 A;  4S2R P;  3MX6 A;  4FLI A;  2GGB A;  2GA2 A;  3Q6D A;  3FMR A;  4U6E A;  4IKR A;  1CHM A;  3CB5 A;  4FO8 A;  5CDV A;  4ZWO A;  1XGN A;  3PKE A;  2BHA A;  4U6C A;  2B3K A;  5CLS A;  2B3L A;  2GG3 A;  1QXY A;  5JFR A;  2BHD A;  2ADU A;  4FKC A;  1O0X A;  4IDY A;  3PKC A;  2G6P A;  2GZ5 A;  3D27 A;  3IU7 A;  1W7V A;  2GU4 A;  3FMQ A;  5E5B A;  1A16 A;  1JAW A;  5CNX A;  2Q94 A;  5FCF A;  2GG7 A;  5CE6 A;  3CTZ A;  1WY2 A;  2GG2 A;  2HOW A;  3TB5 A;  3L24 A;  1QXZ A;  1QXW A;  2NQ7 A;  2Q96 A;  4U1B A;  1C23 A;  3RVA A;  4B28 A;  1MAT A;  3BIQ A;  2BWY A;  4IKT A;  1WL6 A;  4A6W A;  1N51 A;  1YVM A;  1BN5 A;  5CIK A;  1WN1 A;  4KM3 A; 
#chains in the Genus database with same CATH topology
 4PNC A;  2OKN A;  1YJ3 A;  2Q95 A;  4U69 A;  4A6V A;  2BN7 A;  2BWW A;  4U6J A;  1YW7 A;  2EVO A;  2EVM A;  2V3X A;  1C24 A;  1C22 A;  3IU8 A;  2BH3 A;  2P99 A;  2ZSG A;  3S6B A;  1R5G A;  2GG8 A;  1QZY A;  2Q93 A;  2IW2 A;  2BWS A;  3IG4 A;  2P9A A;  4JUQ A;  4HXX A;  4RZY A;  2EA4 A;  4U76 A;  2BHB A;  4OOK A;  4RGZ 1;  1R5H A;  1KQ9 A;  2GU7 A;  1W2M A;  3PKB A;  4IPA A;  4IEC A;  5CDL A;  4S00 A;  1Y1N A;  3PKD A;  1XNZ A;  4FLK A;  1XGM A;  4MAT A;  2GGC A;  2Q8K A;  2EVC A;  2B3H A;  3PKA A;  1B59 A;  4U70 A;  1XGO A;  1PV9 A;  2MAT A;  4U6Z A;  1M35 A;  4FLJ A;  2BWU A;  1R58 A;  2OAZ A;  1C27 A;  2GG5 A;  3CB6 A;  4S2T P;  1B6A A;  5JI6 A;  1YW8 A;  1WKM A;  2BB7 A;  4FLL A;  5JHU A;  4EGE A;  1XGS A;  3ROR A;  3TAV A;  2BWX A;  4U6W A;  1WBQ A;  1KP0 A;  2BWV A;  2EA2 A;  2NQ6 A;  4FUK A;  4QR8 A;  5D6E A;  4IF7 A;  1YW9 A;  3BIT A;  3L7G A;  4IU6 A;  3BIP A;  4ZWU A;  4PV4 A;  1WL9 A;  4U71 A;  4Z7M A;  3FM3 A;  2Q92 A;  2V3Z A;  4ZNG A;  1KQ0 A;  2GG9 A;  4U75 A;  5D6F A;  5CDE A;  2GTX A;  2GG0 A;  3MAT A;  4ZWP A;  1C21 A;  1BOA A;  1WLR A;  2V3Y A;  4FO7 A;  4RZZ A;  2P98 A;  4S01 A;  5FCH A;  4U73 A;  2DFI A;  3IU9 A;  4R60 A;  3MR1 A;  2BWT A;  2GU5 A;  4IKU A;  2BHC A;  4IKS A;  2V6C A;  2GU6 A;  4S2R P;  3MX6 A;  4FLI A;  2GGB A;  2GA2 A;  3Q6D A;  3FMR A;  4U6E A;  4IKR A;  1CHM A;  3CB5 A;  4FO8 A;  5CDV A;  4ZWO A;  1XGN A;  3PKE A;  2BHA A;  4U6C A;  2B3K A;  5CLS A;  2B3L A;  2GG3 A;  1QXY A;  5JFR A;  2BHD A;  2ADU A;  4FKC A;  1O0X A;  4IDY A;  3PKC A;  2G6P A;  2GZ5 A;  3D27 A;  3IU7 A;  1W7V A;  2GU4 A;  3FMQ A;  5E5B A;  1A16 A;  1JAW A;  5CNX A;  2Q94 A;  5FCF A;  2GG7 A;  5CE6 A;  3CTZ A;  1WY2 A;  2GG2 A;  2HOW A;  3TB5 A;  3L24 A;  1QXZ A;  1QXW A;  2NQ7 A;  2Q96 A;  4U1B A;  1C23 A;  3RVA A;  4B28 A;  1MAT A;  3BIQ A;  2BWY A;  4IKT A;  1WL6 A;  4A6W A;  1N51 A;  1YVM A;  1BN5 A;  5CIK A;  1WN1 A;  4KM3 A; 
#chains in the Genus database with same CATH homology
 4PNC A;  2OKN A;  1YJ3 A;  2Q95 A;  4U69 A;  4A6V A;  2BN7 A;  2BWW A;  4U6J A;  1YW7 A;  2EVO A;  2EVM A;  2V3X A;  1C24 A;  1C22 A;  3IU8 A;  2BH3 A;  2P99 A;  2ZSG A;  3S6B A;  1R5G A;  2GG8 A;  1QZY A;  2Q93 A;  2IW2 A;  2BWS A;  3IG4 A;  2P9A A;  4JUQ A;  4HXX A;  4RZY A;  2EA4 A;  4U76 A;  2BHB A;  4OOK A;  4RGZ 1;  1R5H A;  1KQ9 A;  2GU7 A;  1W2M A;  3PKB A;  4IPA A;  4IEC A;  5CDL A;  4S00 A;  1Y1N A;  3PKD A;  1XNZ A;  4FLK A;  1XGM A;  4MAT A;  2GGC A;  2Q8K A;  2EVC A;  2B3H A;  3PKA A;  1B59 A;  4U70 A;  1XGO A;  1PV9 A;  2MAT A;  4U6Z A;  1M35 A;  4FLJ A;  2BWU A;  1R58 A;  2OAZ A;  1C27 A;  2GG5 A;  3CB6 A;  4S2T P;  1B6A A;  5JI6 A;  1YW8 A;  1WKM A;  2BB7 A;  4FLL A;  5JHU A;  4EGE A;  1XGS A;  3ROR A;  3TAV A;  2BWX A;  4U6W A;  1WBQ A;  1KP0 A;  2BWV A;  2EA2 A;  2NQ6 A;  4FUK A;  4QR8 A;  5D6E A;  4IF7 A;  1YW9 A;  3BIT A;  3L7G A;  4IU6 A;  3BIP A;  4ZWU A;  4PV4 A;  1WL9 A;  4U71 A;  4Z7M A;  3FM3 A;  2Q92 A;  2V3Z A;  4ZNG A;  1KQ0 A;  2GG9 A;  4U75 A;  5D6F A;  5CDE A;  2GTX A;  2GG0 A;  3MAT A;  4ZWP A;  1C21 A;  1BOA A;  1WLR A;  2V3Y A;  4FO7 A;  4RZZ A;  2P98 A;  4S01 A;  5FCH A;  4U73 A;  2DFI A;  3IU9 A;  4R60 A;  3MR1 A;  2BWT A;  2GU5 A;  4IKU A;  2BHC A;  4IKS A;  2V6C A;  2GU6 A;  4S2R P;  3MX6 A;  4FLI A;  2GGB A;  2GA2 A;  3Q6D A;  3FMR A;  4U6E A;  4IKR A;  1CHM A;  3CB5 A;  4FO8 A;  5CDV A;  4ZWO A;  1XGN A;  3PKE A;  2BHA A;  4U6C A;  2B3K A;  5CLS A;  2B3L A;  2GG3 A;  1QXY A;  5JFR A;  2BHD A;  2ADU A;  4FKC A;  1O0X A;  4IDY A;  3PKC A;  2G6P A;  2GZ5 A;  3D27 A;  3IU7 A;  1W7V A;  2GU4 A;  3FMQ A;  5E5B A;  1A16 A;  1JAW A;  5CNX A;  2Q94 A;  5FCF A;  2GG7 A;  5CE6 A;  3CTZ A;  1WY2 A;  2GG2 A;  2HOW A;  3TB5 A;  3L24 A;  1QXZ A;  1QXW A;  2NQ7 A;  2Q96 A;  4U1B A;  1C23 A;  3RVA A;  4B28 A;  1MAT A;  3BIQ A;  2BWY A;  4IKT A;  1WL6 A;  4A6W A;  1N51 A;  1YVM A;  1BN5 A;  5CIK A;  1WN1 A;  4KM3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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