1YVMA

E. coli methionine aminopeptidase in complex with thiabendazole
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli
publication title Metal Ions as Cofactors for the Binding of Inhibitors to Methionine Aminopeptidase: A Critical View of the Relevance of In Vitro Metalloenzyme Assays.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1yvmA00
1YW8A 1M35A 3PKEA 4IKUA 5FCFA 2GG7A 4IPAA 4U6JA 1WN1A 2BWYA 4FLLA 4FO7A 5CE6A 1MATA 1KQ0A 1R5HA 2GG3A 2MATA 3TB5A 4ZWUA 1XNZA 5JHUA 3CB6A 4OOKA 3BIQA 5JFRA 4QR8A 1R5GA 1WY2A 3IU9A 3IU8A 4U75A 1YW9A 1CHMA 1XGSA 4KM3A 2NQ6A 4U71A 2ADUA 3BITA 1XGNA 2GTXA 1C27A 2GGCA 4B28A 2BWUA 1WBQA 5FCHA 1B59A 1WLRA 3MR1A 2BWTA 2GG2A 4R60A 3L24A 1XGMA 4RZYA 2BWWA 2ZSGA 1O0XA 3BIPA 1YW7A 2V3XA 4RZZA 2GG0A 2EA2A 4FO8A 1QXYA 2BWSA 2BB7A 4U76A 4IU6A 2Q93A 3PKBA 1QXZA 2HOWA 4FKCA 1W2MA 1QXWA 1WL9A 2V3ZA 1B6AA 3IU7A 2Q95A 2GG9A 4MATA 2V6CA 2BH3A 2G6PA 5CDLA 2OKNA 2GU6A 2OAZA 2EVCA 1QZYA 2EA4A 2B3LA 4U6ZA 3S6BA 4IKTA 1JAWA 5E5BA 5CLSA 3PKAA 2BHBA 1KP0A 4ZNGA 2GU4A 4U70A 4U6CA 1YVMA 2Q8KA 3L7GA 5CDEA 2BHCA 3IG4A 4FLIA 4HXXA 1PV9A 2GZ5A 4EGEA 2Q92A 2IW2A 3FMQA 1N51A 1XGOA 2BN7A 1WL6A 1C23A 5CDVA 2B3KA 1YJ3A 3Q6DA 2DFIA 2GU5A 3MATA 2BHDA 2BWVA 4IDYA 4A6WA 4IECA 5JI6A 3PKCA 1C22A 3CB5A 4RGZ1 4U73A 4S2RP 1BN5A 2P99A 1C21A 4S2TP 2BHAA 5CNXA 2V3YA 4U69A 1KQ9A 4IKRA 2GA2A 5CIKA 1A16A 5D6EA 3FM3A 4U1BA 2Q96A 4IF7A 1R58A 3MX6A 1C24A 4JUQA 3TAVA 2EVMA 4FLKA 2B3HA 4FUKA 2NQ7A 1Y1NA 2GGBA 1W7VA 3CTZA 4FLJA 4IKSA 2P9AA 1WKMA 3FMRA 4S01A 1BOAA 4PV4A 4ZWOA 4U6EA 2GG8A 4S00A 3RORA 2EVOA 4Z7MA 2BWXA 3RVAA 5D6FA 3D27A 3PKDA 4PNCA 4A6VA 2GG5A 2Q94A 4ZWPA 4U6WA 2P98A 2GU7A
chains in the Genus database with same CATH superfamily
1YW8A 1M35A 3PKEA 4IKUA 5FCFA 2GG7A 4IPAA 4U6JA 1WN1A 2BWYA 4FLLA 4FO7A 5CE6A 1MATA 1KQ0A 1R5HA 2GG3A 2MATA 3TB5A 4ZWUA 1XNZA 5JHUA 3CB6A 4OOKA 3BIQA 5JFRA 4QR8A 1R5GA 1WY2A 3IU9A 3IU8A 4U75A 1YW9A 1CHMA 1XGSA 4KM3A 2NQ6A 4U71A 2ADUA 3BITA 1XGNA 2GTXA 1C27A 2GGCA 4B28A 2BWUA 1WBQA 5FCHA 1B59A 1WLRA 3MR1A 2BWTA 2GG2A 4R60A 3L24A 1XGMA 4RZYA 2BWWA 2ZSGA 1O0XA 3BIPA 1YW7A 2V3XA 4RZZA 2GG0A 2EA2A 4FO8A 1QXYA 2BWSA 2BB7A 4U76A 4IU6A 2Q93A 3PKBA 1QXZA 2HOWA 4FKCA 1W2MA 1QXWA 1WL9A 2V3ZA 1B6AA 3IU7A 2Q95A 2GG9A 4MATA 2V6CA 2BH3A 2G6PA 5CDLA 2OKNA 2GU6A 2OAZA 2EVCA 1QZYA 2EA4A 2B3LA 4U6ZA 3S6BA 4IKTA 1JAWA 5E5BA 5CLSA 3PKAA 2BHBA 1KP0A 4ZNGA 2GU4A 4U70A 4U6CA 1YVMA 2Q8KA 3L7GA 5CDEA 2BHCA 3IG4A 4FLIA 4HXXA 1PV9A 2GZ5A 4EGEA 2Q92A 2IW2A 3FMQA 1N51A 1XGOA 2BN7A 1WL6A 1C23A 5CDVA 2B3KA 1YJ3A 3Q6DA 2DFIA 2GU5A 3MATA 2BHDA 2BWVA 4IDYA 4A6WA 4IECA 5JI6A 3PKCA 1C22A 3CB5A 4RGZ1 4U73A 4S2RP 1BN5A 2P99A 1C21A 4S2TP 2BHAA 5CNXA 2V3YA 4U69A 1KQ9A 4IKRA 2GA2A 5CIKA 1A16A 5D6EA 3FM3A 4U1BA 2Q96A 4IF7A 1R58A 3MX6A 1C24A 4JUQA 3TAVA 2EVMA 4FLKA 2B3HA 4FUKA 2NQ7A 1Y1NA 2GGBA 1W7VA 3CTZA 4FLJA 4IKSA 2P9AA 1WKMA 3FMRA 4S01A 1BOAA 4PV4A 4ZWOA 4U6EA 2GG8A 4S00A 3RORA 2EVOA 4Z7MA 2BWXA 3RVAA 5D6FA 3D27A 3PKDA 4PNCA 4A6VA 2GG5A 2Q94A 4ZWPA 4U6WA 2P98A 2GU7A
chains in the Genus database with same CATH topology
1YW8A 1M35A 3PKEA 4IKUA 5FCFA 2GG7A 4IPAA 4U6JA 1WN1A 2BWYA 4FLLA 4FO7A 5CE6A 1MATA 1KQ0A 1R5HA 2GG3A 2MATA 3TB5A 4ZWUA 1XNZA 5JHUA 3CB6A 4OOKA 3BIQA 5JFRA 4QR8A 1R5GA 1WY2A 3IU9A 3IU8A 4U75A 1YW9A 1CHMA 1XGSA 4KM3A 2NQ6A 4U71A 2ADUA 3BITA 1XGNA 2GTXA 1C27A 2GGCA 4B28A 2BWUA 1WBQA 5FCHA 1B59A 1WLRA 3MR1A 2BWTA 2GG2A 4R60A 3L24A 1XGMA 4RZYA 2BWWA 2ZSGA 1O0XA 3BIPA 1YW7A 2V3XA 4RZZA 2GG0A 2EA2A 4FO8A 1QXYA 2BWSA 2BB7A 4U76A 4IU6A 2Q93A 3PKBA 1QXZA 2HOWA 4FKCA 1W2MA 1QXWA 1WL9A 2V3ZA 1B6AA 3IU7A 2Q95A 2GG9A 4MATA 2V6CA 2BH3A 2G6PA 5CDLA 2OKNA 2GU6A 2OAZA 2EVCA 1QZYA 2EA4A 2B3LA 4U6ZA 3S6BA 4IKTA 1JAWA 5E5BA 5CLSA 3PKAA 2BHBA 1KP0A 4ZNGA 2GU4A 4U70A 4U6CA 1YVMA 2Q8KA 3L7GA 5CDEA 2BHCA 3IG4A 4FLIA 4HXXA 1PV9A 2GZ5A 4EGEA 2Q92A 2IW2A 3FMQA 1N51A 1XGOA 2BN7A 1WL6A 1C23A 5CDVA 2B3KA 1YJ3A 3Q6DA 2DFIA 2GU5A 3MATA 2BHDA 2BWVA 4IDYA 4A6WA 4IECA 5JI6A 3PKCA 1C22A 3CB5A 4RGZ1 4U73A 4S2RP 1BN5A 2P99A 1C21A 4S2TP 2BHAA 5CNXA 2V3YA 4U69A 1KQ9A 4IKRA 2GA2A 5CIKA 1A16A 5D6EA 3FM3A 4U1BA 2Q96A 4IF7A 1R58A 3MX6A 1C24A 4JUQA 3TAVA 2EVMA 4FLKA 2B3HA 4FUKA 2NQ7A 1Y1NA 2GGBA 1W7VA 3CTZA 4FLJA 4IKSA 2P9AA 1WKMA 3FMRA 4S01A 1BOAA 4PV4A 4ZWOA 4U6EA 2GG8A 4S00A 3RORA 2EVOA 4Z7MA 2BWXA 3RVAA 5D6FA 3D27A 3PKDA 4PNCA 4A6VA 2GG5A 2Q94A 4ZWPA 4U6WA 2P98A 2GU7A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1YW8 A;  1M35 A;  3PKE A;  4IKU A;  5FCF A;  2GG7 A;  4IPA A;  4U6J A;  1WN1 A;  2BWY A;  4FLL A;  4FO7 A;  5CE6 A;  1MAT A;  1KQ0 A;  1R5H A;  2GG3 A;  2MAT A;  3TB5 A;  4ZWU A;  1XNZ A;  5JHU A;  3CB6 A;  4OOK A;  3BIQ A;  5JFR A;  4QR8 A;  1R5G A;  1WY2 A;  3IU9 A;  3IU8 A;  4U75 A;  1YW9 A;  1CHM A;  1XGS A;  4KM3 A;  2NQ6 A;  4U71 A;  2ADU A;  3BIT A;  1XGN A;  2GTX A;  1C27 A;  2GGC A;  4B28 A;  2BWU A;  1WBQ A;  5FCH A;  1B59 A;  1WLR A;  3MR1 A;  2BWT A;  2GG2 A;  4R60 A;  3L24 A;  1XGM A;  4RZY A;  2BWW A;  2ZSG A;  1O0X A;  3BIP A;  1YW7 A;  2V3X A;  4RZZ A;  2GG0 A;  2EA2 A;  4FO8 A;  1QXY A;  2BWS A;  2BB7 A;  4U76 A;  4IU6 A;  2Q93 A;  3PKB A;  1QXZ A;  2HOW A;  4FKC A;  1W2M A;  1QXW A;  1WL9 A;  2V3Z A;  1B6A A;  3IU7 A;  2Q95 A;  2GG9 A;  4MAT A;  2V6C A;  2BH3 A;  2G6P A;  5CDL A;  2OKN A;  2GU6 A;  2OAZ A;  2EVC A;  1QZY A;  2EA4 A;  2B3L A;  4U6Z A;  3S6B A;  4IKT A;  1JAW A;  5E5B A;  5CLS A;  3PKA A;  2BHB A;  1KP0 A;  4ZNG A;  2GU4 A;  4U70 A;  4U6C A;  1YVM A;  2Q8K A;  3L7G A;  5CDE A;  2BHC A;  3IG4 A;  4FLI A;  4HXX A;  1PV9 A;  2GZ5 A;  4EGE A;  2Q92 A;  2IW2 A;  3FMQ A;  1N51 A;  1XGO A;  2BN7 A;  1WL6 A;  1C23 A;  5CDV A;  2B3K A;  1YJ3 A;  3Q6D A;  2DFI A;  2GU5 A;  3MAT A;  2BHD A;  2BWV A;  4IDY A;  4A6W A;  4IEC A;  5JI6 A;  3PKC A;  1C22 A;  3CB5 A;  4RGZ 1;  4U73 A;  4S2R P;  1BN5 A;  2P99 A;  1C21 A;  4S2T P;  2BHA A;  5CNX A;  2V3Y A;  4U69 A;  1KQ9 A;  4IKR A;  2GA2 A;  5CIK A;  1A16 A;  5D6E A;  3FM3 A;  4U1B A;  2Q96 A;  4IF7 A;  1R58 A;  3MX6 A;  1C24 A;  4JUQ A;  3TAV A;  2EVM A;  4FLK A;  2B3H A;  4FUK A;  2NQ7 A;  1Y1N A;  2GGB A;  1W7V A;  3CTZ A;  4FLJ A;  4IKS A;  2P9A A;  1WKM A;  3FMR A;  4S01 A;  1BOA A;  4PV4 A;  4ZWO A;  4U6E A;  2GG8 A;  4S00 A;  3ROR A;  2EVO A;  4Z7M A;  2BWX A;  3RVA A;  5D6F A;  3D27 A;  3PKD A;  4PNC A;  4A6V A;  2GG5 A;  2Q94 A;  4ZWP A;  4U6W A;  2P98 A;  2GU7 A; 
#chains in the Genus database with same CATH topology
 1YW8 A;  1M35 A;  3PKE A;  4IKU A;  5FCF A;  2GG7 A;  4IPA A;  4U6J A;  1WN1 A;  2BWY A;  4FLL A;  4FO7 A;  5CE6 A;  1MAT A;  1KQ0 A;  1R5H A;  2GG3 A;  2MAT A;  3TB5 A;  4ZWU A;  1XNZ A;  5JHU A;  3CB6 A;  4OOK A;  3BIQ A;  5JFR A;  4QR8 A;  1R5G A;  1WY2 A;  3IU9 A;  3IU8 A;  4U75 A;  1YW9 A;  1CHM A;  1XGS A;  4KM3 A;  2NQ6 A;  4U71 A;  2ADU A;  3BIT A;  1XGN A;  2GTX A;  1C27 A;  2GGC A;  4B28 A;  2BWU A;  1WBQ A;  5FCH A;  1B59 A;  1WLR A;  3MR1 A;  2BWT A;  2GG2 A;  4R60 A;  3L24 A;  1XGM A;  4RZY A;  2BWW A;  2ZSG A;  1O0X A;  3BIP A;  1YW7 A;  2V3X A;  4RZZ A;  2GG0 A;  2EA2 A;  4FO8 A;  1QXY A;  2BWS A;  2BB7 A;  4U76 A;  4IU6 A;  2Q93 A;  3PKB A;  1QXZ A;  2HOW A;  4FKC A;  1W2M A;  1QXW A;  1WL9 A;  2V3Z A;  1B6A A;  3IU7 A;  2Q95 A;  2GG9 A;  4MAT A;  2V6C A;  2BH3 A;  2G6P A;  5CDL A;  2OKN A;  2GU6 A;  2OAZ A;  2EVC A;  1QZY A;  2EA4 A;  2B3L A;  4U6Z A;  3S6B A;  4IKT A;  1JAW A;  5E5B A;  5CLS A;  3PKA A;  2BHB A;  1KP0 A;  4ZNG A;  2GU4 A;  4U70 A;  4U6C A;  1YVM A;  2Q8K A;  3L7G A;  5CDE A;  2BHC A;  3IG4 A;  4FLI A;  4HXX A;  1PV9 A;  2GZ5 A;  4EGE A;  2Q92 A;  2IW2 A;  3FMQ A;  1N51 A;  1XGO A;  2BN7 A;  1WL6 A;  1C23 A;  5CDV A;  2B3K A;  1YJ3 A;  3Q6D A;  2DFI A;  2GU5 A;  3MAT A;  2BHD A;  2BWV A;  4IDY A;  4A6W A;  4IEC A;  5JI6 A;  3PKC A;  1C22 A;  3CB5 A;  4RGZ 1;  4U73 A;  4S2R P;  1BN5 A;  2P99 A;  1C21 A;  4S2T P;  2BHA A;  5CNX A;  2V3Y A;  4U69 A;  1KQ9 A;  4IKR A;  2GA2 A;  5CIK A;  1A16 A;  5D6E A;  3FM3 A;  4U1B A;  2Q96 A;  4IF7 A;  1R58 A;  3MX6 A;  1C24 A;  4JUQ A;  3TAV A;  2EVM A;  4FLK A;  2B3H A;  4FUK A;  2NQ7 A;  1Y1N A;  2GGB A;  1W7V A;  3CTZ A;  4FLJ A;  4IKS A;  2P9A A;  1WKM A;  3FMR A;  4S01 A;  1BOA A;  4PV4 A;  4ZWO A;  4U6E A;  2GG8 A;  4S00 A;  3ROR A;  2EVO A;  4Z7M A;  2BWX A;  3RVA A;  5D6F A;  3D27 A;  3PKD A;  4PNC A;  4A6V A;  2GG5 A;  2Q94 A;  4ZWP A;  4U6W A;  2P98 A;  2GU7 A; 
#chains in the Genus database with same CATH homology
 1YW8 A;  1M35 A;  3PKE A;  4IKU A;  5FCF A;  2GG7 A;  4IPA A;  4U6J A;  1WN1 A;  2BWY A;  4FLL A;  4FO7 A;  5CE6 A;  1MAT A;  1KQ0 A;  1R5H A;  2GG3 A;  2MAT A;  3TB5 A;  4ZWU A;  1XNZ A;  5JHU A;  3CB6 A;  4OOK A;  3BIQ A;  5JFR A;  4QR8 A;  1R5G A;  1WY2 A;  3IU9 A;  3IU8 A;  4U75 A;  1YW9 A;  1CHM A;  1XGS A;  4KM3 A;  2NQ6 A;  4U71 A;  2ADU A;  3BIT A;  1XGN A;  2GTX A;  1C27 A;  2GGC A;  4B28 A;  2BWU A;  1WBQ A;  5FCH A;  1B59 A;  1WLR A;  3MR1 A;  2BWT A;  2GG2 A;  4R60 A;  3L24 A;  1XGM A;  4RZY A;  2BWW A;  2ZSG A;  1O0X A;  3BIP A;  1YW7 A;  2V3X A;  4RZZ A;  2GG0 A;  2EA2 A;  4FO8 A;  1QXY A;  2BWS A;  2BB7 A;  4U76 A;  4IU6 A;  2Q93 A;  3PKB A;  1QXZ A;  2HOW A;  4FKC A;  1W2M A;  1QXW A;  1WL9 A;  2V3Z A;  1B6A A;  3IU7 A;  2Q95 A;  2GG9 A;  4MAT A;  2V6C A;  2BH3 A;  2G6P A;  5CDL A;  2OKN A;  2GU6 A;  2OAZ A;  2EVC A;  1QZY A;  2EA4 A;  2B3L A;  4U6Z A;  3S6B A;  4IKT A;  1JAW A;  5E5B A;  5CLS A;  3PKA A;  2BHB A;  1KP0 A;  4ZNG A;  2GU4 A;  4U70 A;  4U6C A;  1YVM A;  2Q8K A;  3L7G A;  5CDE A;  2BHC A;  3IG4 A;  4FLI A;  4HXX A;  1PV9 A;  2GZ5 A;  4EGE A;  2Q92 A;  2IW2 A;  3FMQ A;  1N51 A;  1XGO A;  2BN7 A;  1WL6 A;  1C23 A;  5CDV A;  2B3K A;  1YJ3 A;  3Q6D A;  2DFI A;  2GU5 A;  3MAT A;  2BHD A;  2BWV A;  4IDY A;  4A6W A;  4IEC A;  5JI6 A;  3PKC A;  1C22 A;  3CB5 A;  4RGZ 1;  4U73 A;  4S2R P;  1BN5 A;  2P99 A;  1C21 A;  4S2T P;  2BHA A;  5CNX A;  2V3Y A;  4U69 A;  1KQ9 A;  4IKR A;  2GA2 A;  5CIK A;  1A16 A;  5D6E A;  3FM3 A;  4U1B A;  2Q96 A;  4IF7 A;  1R58 A;  3MX6 A;  1C24 A;  4JUQ A;  3TAV A;  2EVM A;  4FLK A;  2B3H A;  4FUK A;  2NQ7 A;  1Y1N A;  2GGB A;  1W7V A;  3CTZ A;  4FLJ A;  4IKS A;  2P9A A;  1WKM A;  3FMR A;  4S01 A;  1BOA A;  4PV4 A;  4ZWO A;  4U6E A;  2GG8 A;  4S00 A;  3ROR A;  2EVO A;  4Z7M A;  2BWX A;  3RVA A;  5D6F A;  3D27 A;  3PKD A;  4PNC A;  4A6V A;  2GG5 A;  2Q94 A;  4ZWP A;  4U6W A;  2P98 A;  2GU7 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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