1C21A

E. coli methionine aminopeptidase: methionine complex
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords METHIONINE AMINOPEPTIDASE
publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
source organism Escherichia coli
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c21A00
1B6AA 2BB7A 4IPAA 1XGMA 2BWYA 2BWXA 4IU6A 4PNCA 4KM3A 4IKRA 3MATA 5D6EA 2V3XA 2BWSA 2EA4A 2GG7A 4IF7A 4FLJA 1C23A 4U6ZA 2EVCA 2P99A 3TAVA 4IKTA 2BWWA 4S01A 1XGOA 2GG3A 5FCFA 3CB6A 5JHUA 1W2MA 4FKCA 3S6BA 2P98A 2Q8KA 1N51A 1C27A 1M35A 2IW2A 2V3ZA 1YW7A 1PV9A 2P9AA 4RZYA 2GTXA 2BN7A 1R5HA 4U6JA 1QXYA 2BHAA 2B3LA 4IKSA 4OOKA 5D6FA 2Q96A 2Q94A 3RVAA 2BWUA 5FCHA 1QXZA 4QR8A 4Z7MA 2G6PA 1WN1A 1KQ9A 5CDVA 1W7VA 3PKBA 4IDYA 2Q95A 1Y1NA 4R60A 4RZZA 2OKNA 3IU9A 4ZNGA 2EA2A 2Q93A 2EVOA 5CIKA 4FLIA 4S2RP 5CNXA 2GG5A 3MX6A 5CE6A 1WL6A 1C21A 2V3YA 3PKEA 1O0XA 2GG9A 4ZWPA 2B3HA 5E5BA 1WL9A 1YJ3A 3CB5A 4FUKA 2BHBA 2GG8A 3BIPA 4B28A 4FO8A 2BWVA 3IG4A 4ZWOA 3D27A 2GU6A 3CTZA 2BWTA 3PKAA 4PV4A 5CLSA 1MATA 1JAWA 2GZ5A 1QZYA 2ZSGA 4EGEA 4U70A 3FMRA 2GU4A 1WLRA 3TB5A 5CDEA 2BHDA 1BOAA 2GGCA 2V6CA 4FLKA 2MATA 4FO7A 4U6EA 4FLLA 2GU5A 4U6WA 2GG0A 1KP0A 4U1BA 3L7GA 1B59A 1C24A 4ZWUA 2Q92A 4JUQA 3PKDA 2EVMA 1WBQA 1KQ0A 1XNZA 3MR1A 4IKUA 3IU8A 1YW8A 1XGSA 2DFIA 1BN5A 4U73A 2B3KA 3BIQA 5JI6A 2NQ7A 1YVMA 1CHMA 3L24A 2HOWA 2GG2A 4U6CA 4U75A 5JFRA 4RGZ1 2NQ6A 4U76A 4S2TP 1QXWA 4U71A 2OAZA 2BH3A 3FMQA 1C22A 1A16A 3BITA 4IECA 2ADUA 4U69A 1XGNA 2GA2A 5CDLA 4A6VA 2BHCA 4MATA 4A6WA 1R5GA 2GU7A 3Q6DA 3RORA 1R58A 3FM3A 1WKMA 1WY2A 2GGBA 3IU7A 1YW9A 4HXXA 4S00A 3PKCA
chains in the Genus database with same CATH superfamily
1B6AA 2BB7A 4IPAA 1XGMA 2BWYA 2BWXA 4IU6A 4PNCA 4KM3A 4IKRA 3MATA 5D6EA 2V3XA 2BWSA 2EA4A 2GG7A 4IF7A 4FLJA 1C23A 4U6ZA 2EVCA 2P99A 3TAVA 4IKTA 2BWWA 4S01A 1XGOA 2GG3A 5FCFA 3CB6A 5JHUA 1W2MA 4FKCA 3S6BA 2P98A 2Q8KA 1N51A 1C27A 1M35A 2IW2A 2V3ZA 1YW7A 1PV9A 2P9AA 4RZYA 2GTXA 2BN7A 1R5HA 4U6JA 1QXYA 2BHAA 2B3LA 4IKSA 4OOKA 5D6FA 2Q96A 2Q94A 3RVAA 2BWUA 5FCHA 1QXZA 4QR8A 4Z7MA 2G6PA 1WN1A 1KQ9A 5CDVA 1W7VA 3PKBA 4IDYA 2Q95A 1Y1NA 4R60A 4RZZA 2OKNA 3IU9A 4ZNGA 2EA2A 2Q93A 2EVOA 5CIKA 4FLIA 4S2RP 5CNXA 2GG5A 3MX6A 5CE6A 1WL6A 1C21A 2V3YA 3PKEA 1O0XA 2GG9A 4ZWPA 2B3HA 5E5BA 1WL9A 1YJ3A 3CB5A 4FUKA 2BHBA 2GG8A 3BIPA 4B28A 4FO8A 2BWVA 3IG4A 4ZWOA 3D27A 2GU6A 3CTZA 2BWTA 3PKAA 4PV4A 5CLSA 1MATA 1JAWA 2GZ5A 1QZYA 2ZSGA 4EGEA 4U70A 3FMRA 2GU4A 1WLRA 3TB5A 5CDEA 2BHDA 1BOAA 2GGCA 2V6CA 4FLKA 2MATA 4FO7A 4U6EA 4FLLA 2GU5A 4U6WA 2GG0A 1KP0A 4U1BA 3L7GA 1B59A 1C24A 4ZWUA 2Q92A 4JUQA 3PKDA 2EVMA 1WBQA 1KQ0A 1XNZA 3MR1A 4IKUA 3IU8A 1YW8A 1XGSA 2DFIA 1BN5A 4U73A 2B3KA 3BIQA 5JI6A 2NQ7A 1YVMA 1CHMA 3L24A 2HOWA 2GG2A 4U6CA 4U75A 5JFRA 4RGZ1 2NQ6A 4U76A 4S2TP 1QXWA 4U71A 2OAZA 2BH3A 3FMQA 1C22A 1A16A 3BITA 4IECA 2ADUA 4U69A 1XGNA 2GA2A 5CDLA 4A6VA 2BHCA 4MATA 4A6WA 1R5GA 2GU7A 3Q6DA 3RORA 1R58A 3FM3A 1WKMA 1WY2A 2GGBA 3IU7A 1YW9A 4HXXA 4S00A 3PKCA
chains in the Genus database with same CATH topology
1B6AA 2BB7A 4IPAA 1XGMA 2BWYA 2BWXA 4IU6A 4PNCA 4KM3A 4IKRA 3MATA 5D6EA 2V3XA 2BWSA 2EA4A 2GG7A 4IF7A 4FLJA 1C23A 4U6ZA 2EVCA 2P99A 3TAVA 4IKTA 2BWWA 4S01A 1XGOA 2GG3A 5FCFA 3CB6A 5JHUA 1W2MA 4FKCA 3S6BA 2P98A 2Q8KA 1N51A 1C27A 1M35A 2IW2A 2V3ZA 1YW7A 1PV9A 2P9AA 4RZYA 2GTXA 2BN7A 1R5HA 4U6JA 1QXYA 2BHAA 2B3LA 4IKSA 4OOKA 5D6FA 2Q96A 2Q94A 3RVAA 2BWUA 5FCHA 1QXZA 4QR8A 4Z7MA 2G6PA 1WN1A 1KQ9A 5CDVA 1W7VA 3PKBA 4IDYA 2Q95A 1Y1NA 4R60A 4RZZA 2OKNA 3IU9A 4ZNGA 2EA2A 2Q93A 2EVOA 5CIKA 4FLIA 4S2RP 5CNXA 2GG5A 3MX6A 5CE6A 1WL6A 1C21A 2V3YA 3PKEA 1O0XA 2GG9A 4ZWPA 2B3HA 5E5BA 1WL9A 1YJ3A 3CB5A 4FUKA 2BHBA 2GG8A 3BIPA 4B28A 4FO8A 2BWVA 3IG4A 4ZWOA 3D27A 2GU6A 3CTZA 2BWTA 3PKAA 4PV4A 5CLSA 1MATA 1JAWA 2GZ5A 1QZYA 2ZSGA 4EGEA 4U70A 3FMRA 2GU4A 1WLRA 3TB5A 5CDEA 2BHDA 1BOAA 2GGCA 2V6CA 4FLKA 2MATA 4FO7A 4U6EA 4FLLA 2GU5A 4U6WA 2GG0A 1KP0A 4U1BA 3L7GA 1B59A 1C24A 4ZWUA 2Q92A 4JUQA 3PKDA 2EVMA 1WBQA 1KQ0A 1XNZA 3MR1A 4IKUA 3IU8A 1YW8A 1XGSA 2DFIA 1BN5A 4U73A 2B3KA 3BIQA 5JI6A 2NQ7A 1YVMA 1CHMA 3L24A 2HOWA 2GG2A 4U6CA 4U75A 5JFRA 4RGZ1 2NQ6A 4U76A 4S2TP 1QXWA 4U71A 2OAZA 2BH3A 3FMQA 1C22A 1A16A 3BITA 4IECA 2ADUA 4U69A 1XGNA 2GA2A 5CDLA 4A6VA 2BHCA 4MATA 4A6WA 1R5GA 2GU7A 3Q6DA 3RORA 1R58A 3FM3A 1WKMA 1WY2A 2GGBA 3IU7A 1YW9A 4HXXA 4S00A 3PKCA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1B6A A;  2BB7 A;  4IPA A;  1XGM A;  2BWY A;  2BWX A;  4IU6 A;  4PNC A;  4KM3 A;  4IKR A;  3MAT A;  5D6E A;  2V3X A;  2BWS A;  2EA4 A;  2GG7 A;  4IF7 A;  4FLJ A;  1C23 A;  4U6Z A;  2EVC A;  2P99 A;  3TAV A;  4IKT A;  2BWW A;  4S01 A;  1XGO A;  2GG3 A;  5FCF A;  3CB6 A;  5JHU A;  1W2M A;  4FKC A;  3S6B A;  2P98 A;  2Q8K A;  1N51 A;  1C27 A;  1M35 A;  2IW2 A;  2V3Z A;  1YW7 A;  1PV9 A;  2P9A A;  4RZY A;  2GTX A;  2BN7 A;  1R5H A;  4U6J A;  1QXY A;  2BHA A;  2B3L A;  4IKS A;  4OOK A;  5D6F A;  2Q96 A;  2Q94 A;  3RVA A;  2BWU A;  5FCH A;  1QXZ A;  4QR8 A;  4Z7M A;  2G6P A;  1WN1 A;  1KQ9 A;  5CDV A;  1W7V A;  3PKB A;  4IDY A;  2Q95 A;  1Y1N A;  4R60 A;  4RZZ A;  2OKN A;  3IU9 A;  4ZNG A;  2EA2 A;  2Q93 A;  2EVO A;  5CIK A;  4FLI A;  4S2R P;  5CNX A;  2GG5 A;  3MX6 A;  5CE6 A;  1WL6 A;  1C21 A;  2V3Y A;  3PKE A;  1O0X A;  2GG9 A;  4ZWP A;  2B3H A;  5E5B A;  1WL9 A;  1YJ3 A;  3CB5 A;  4FUK A;  2BHB A;  2GG8 A;  3BIP A;  4B28 A;  4FO8 A;  2BWV A;  3IG4 A;  4ZWO A;  3D27 A;  2GU6 A;  3CTZ A;  2BWT A;  3PKA A;  4PV4 A;  5CLS A;  1MAT A;  1JAW A;  2GZ5 A;  1QZY A;  2ZSG A;  4EGE A;  4U70 A;  3FMR A;  2GU4 A;  1WLR A;  3TB5 A;  5CDE A;  2BHD A;  1BOA A;  2GGC A;  2V6C A;  4FLK A;  2MAT A;  4FO7 A;  4U6E A;  4FLL A;  2GU5 A;  4U6W A;  2GG0 A;  1KP0 A;  4U1B A;  3L7G A;  1B59 A;  1C24 A;  4ZWU A;  2Q92 A;  4JUQ A;  3PKD A;  2EVM A;  1WBQ A;  1KQ0 A;  1XNZ A;  3MR1 A;  4IKU A;  3IU8 A;  1YW8 A;  1XGS A;  2DFI A;  1BN5 A;  4U73 A;  2B3K A;  3BIQ A;  5JI6 A;  2NQ7 A;  1YVM A;  1CHM A;  3L24 A;  2HOW A;  2GG2 A;  4U6C A;  4U75 A;  5JFR A;  4RGZ 1;  2NQ6 A;  4U76 A;  4S2T P;  1QXW A;  4U71 A;  2OAZ A;  2BH3 A;  3FMQ A;  1C22 A;  1A16 A;  3BIT A;  4IEC A;  2ADU A;  4U69 A;  1XGN A;  2GA2 A;  5CDL A;  4A6V A;  2BHC A;  4MAT A;  4A6W A;  1R5G A;  2GU7 A;  3Q6D A;  3ROR A;  1R58 A;  3FM3 A;  1WKM A;  1WY2 A;  2GGB A;  3IU7 A;  1YW9 A;  4HXX A;  4S00 A;  3PKC A; 
#chains in the Genus database with same CATH topology
 1B6A A;  2BB7 A;  4IPA A;  1XGM A;  2BWY A;  2BWX A;  4IU6 A;  4PNC A;  4KM3 A;  4IKR A;  3MAT A;  5D6E A;  2V3X A;  2BWS A;  2EA4 A;  2GG7 A;  4IF7 A;  4FLJ A;  1C23 A;  4U6Z A;  2EVC A;  2P99 A;  3TAV A;  4IKT A;  2BWW A;  4S01 A;  1XGO A;  2GG3 A;  5FCF A;  3CB6 A;  5JHU A;  1W2M A;  4FKC A;  3S6B A;  2P98 A;  2Q8K A;  1N51 A;  1C27 A;  1M35 A;  2IW2 A;  2V3Z A;  1YW7 A;  1PV9 A;  2P9A A;  4RZY A;  2GTX A;  2BN7 A;  1R5H A;  4U6J A;  1QXY A;  2BHA A;  2B3L A;  4IKS A;  4OOK A;  5D6F A;  2Q96 A;  2Q94 A;  3RVA A;  2BWU A;  5FCH A;  1QXZ A;  4QR8 A;  4Z7M A;  2G6P A;  1WN1 A;  1KQ9 A;  5CDV A;  1W7V A;  3PKB A;  4IDY A;  2Q95 A;  1Y1N A;  4R60 A;  4RZZ A;  2OKN A;  3IU9 A;  4ZNG A;  2EA2 A;  2Q93 A;  2EVO A;  5CIK A;  4FLI A;  4S2R P;  5CNX A;  2GG5 A;  3MX6 A;  5CE6 A;  1WL6 A;  1C21 A;  2V3Y A;  3PKE A;  1O0X A;  2GG9 A;  4ZWP A;  2B3H A;  5E5B A;  1WL9 A;  1YJ3 A;  3CB5 A;  4FUK A;  2BHB A;  2GG8 A;  3BIP A;  4B28 A;  4FO8 A;  2BWV A;  3IG4 A;  4ZWO A;  3D27 A;  2GU6 A;  3CTZ A;  2BWT A;  3PKA A;  4PV4 A;  5CLS A;  1MAT A;  1JAW A;  2GZ5 A;  1QZY A;  2ZSG A;  4EGE A;  4U70 A;  3FMR A;  2GU4 A;  1WLR A;  3TB5 A;  5CDE A;  2BHD A;  1BOA A;  2GGC A;  2V6C A;  4FLK A;  2MAT A;  4FO7 A;  4U6E A;  4FLL A;  2GU5 A;  4U6W A;  2GG0 A;  1KP0 A;  4U1B A;  3L7G A;  1B59 A;  1C24 A;  4ZWU A;  2Q92 A;  4JUQ A;  3PKD A;  2EVM A;  1WBQ A;  1KQ0 A;  1XNZ A;  3MR1 A;  4IKU A;  3IU8 A;  1YW8 A;  1XGS A;  2DFI A;  1BN5 A;  4U73 A;  2B3K A;  3BIQ A;  5JI6 A;  2NQ7 A;  1YVM A;  1CHM A;  3L24 A;  2HOW A;  2GG2 A;  4U6C A;  4U75 A;  5JFR A;  4RGZ 1;  2NQ6 A;  4U76 A;  4S2T P;  1QXW A;  4U71 A;  2OAZ A;  2BH3 A;  3FMQ A;  1C22 A;  1A16 A;  3BIT A;  4IEC A;  2ADU A;  4U69 A;  1XGN A;  2GA2 A;  5CDL A;  4A6V A;  2BHC A;  4MAT A;  4A6W A;  1R5G A;  2GU7 A;  3Q6D A;  3ROR A;  1R58 A;  3FM3 A;  1WKM A;  1WY2 A;  2GGB A;  3IU7 A;  1YW9 A;  4HXX A;  4S00 A;  3PKC A; 
#chains in the Genus database with same CATH homology
 1B6A A;  2BB7 A;  4IPA A;  1XGM A;  2BWY A;  2BWX A;  4IU6 A;  4PNC A;  4KM3 A;  4IKR A;  3MAT A;  5D6E A;  2V3X A;  2BWS A;  2EA4 A;  2GG7 A;  4IF7 A;  4FLJ A;  1C23 A;  4U6Z A;  2EVC A;  2P99 A;  3TAV A;  4IKT A;  2BWW A;  4S01 A;  1XGO A;  2GG3 A;  5FCF A;  3CB6 A;  5JHU A;  1W2M A;  4FKC A;  3S6B A;  2P98 A;  2Q8K A;  1N51 A;  1C27 A;  1M35 A;  2IW2 A;  2V3Z A;  1YW7 A;  1PV9 A;  2P9A A;  4RZY A;  2GTX A;  2BN7 A;  1R5H A;  4U6J A;  1QXY A;  2BHA A;  2B3L A;  4IKS A;  4OOK A;  5D6F A;  2Q96 A;  2Q94 A;  3RVA A;  2BWU A;  5FCH A;  1QXZ A;  4QR8 A;  4Z7M A;  2G6P A;  1WN1 A;  1KQ9 A;  5CDV A;  1W7V A;  3PKB A;  4IDY A;  2Q95 A;  1Y1N A;  4R60 A;  4RZZ A;  2OKN A;  3IU9 A;  4ZNG A;  2EA2 A;  2Q93 A;  2EVO A;  5CIK A;  4FLI A;  4S2R P;  5CNX A;  2GG5 A;  3MX6 A;  5CE6 A;  1WL6 A;  1C21 A;  2V3Y A;  3PKE A;  1O0X A;  2GG9 A;  4ZWP A;  2B3H A;  5E5B A;  1WL9 A;  1YJ3 A;  3CB5 A;  4FUK A;  2BHB A;  2GG8 A;  3BIP A;  4B28 A;  4FO8 A;  2BWV A;  3IG4 A;  4ZWO A;  3D27 A;  2GU6 A;  3CTZ A;  2BWT A;  3PKA A;  4PV4 A;  5CLS A;  1MAT A;  1JAW A;  2GZ5 A;  1QZY A;  2ZSG A;  4EGE A;  4U70 A;  3FMR A;  2GU4 A;  1WLR A;  3TB5 A;  5CDE A;  2BHD A;  1BOA A;  2GGC A;  2V6C A;  4FLK A;  2MAT A;  4FO7 A;  4U6E A;  4FLL A;  2GU5 A;  4U6W A;  2GG0 A;  1KP0 A;  4U1B A;  3L7G A;  1B59 A;  1C24 A;  4ZWU A;  2Q92 A;  4JUQ A;  3PKD A;  2EVM A;  1WBQ A;  1KQ0 A;  1XNZ A;  3MR1 A;  4IKU A;  3IU8 A;  1YW8 A;  1XGS A;  2DFI A;  1BN5 A;  4U73 A;  2B3K A;  3BIQ A;  5JI6 A;  2NQ7 A;  1YVM A;  1CHM A;  3L24 A;  2HOW A;  2GG2 A;  4U6C A;  4U75 A;  5JFR A;  4RGZ 1;  2NQ6 A;  4U76 A;  4S2T P;  1QXW A;  4U71 A;  2OAZ A;  2BH3 A;  3FMQ A;  1C22 A;  1A16 A;  3BIT A;  4IEC A;  2ADU A;  4U69 A;  1XGN A;  2GA2 A;  5CDL A;  4A6V A;  2BHC A;  4MAT A;  4A6W A;  1R5G A;  2GU7 A;  3Q6D A;  3ROR A;  1R58 A;  3FM3 A;  1WKM A;  1WY2 A;  2GGB A;  3IU7 A;  1YW9 A;  4HXX A;  4S00 A;  3PKC A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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