1C22A

E. coli methionine aminopeptidase: trifluoromethionine complex
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords METHIONINE AMINOPEPTIDASE
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c22A00
4EGEA 4PV4A 5CNXA 1R5HA 4S00A 3D27A 4IECA 1N51A 4IKTA 2NQ6A 1C22A 2BHDA 3FMQA 1W7VA 2OAZA 2EA2A 4FLIA 4RZZA 5D6FA 2EA4A 2GG0A 3CB5A 4FLLA 3L7GA 1WN1A 2BWXA 2V3ZA 4Z7MA 2BWYA 1O0XA 2GU6A 4U69A 2GG2A 3MX6A 4QR8A 2P99A 2Q8KA 5CLSA 2BB7A 3IU8A 1WKMA 4U76A 1C24A 1A16A 2Q95A 4ZNGA 2IW2A 4RGZ1 1XGNA 2BWWA 5CDLA 1B59A 2ZSGA 4IKRA 2P9AA 2GZ5A 2OKNA 3BIPA 4U6ZA 2GU5A 4FLKA 2EVCA 2BH3A 1YJ3A 2BWSA 2BHCA 4ZWPA 3BITA 4IDYA 4FUKA 4IU6A 4S2TP 4U6JA 4FO8A 4RZYA 1KP0A 4U6CA 3S6BA 1M35A 1QXZA 2Q92A 3PKCA 4OOKA 2GG5A 5E5BA 2Q94A 2BHBA 1MATA 2GGCA 4MATA 4U73A 4R60A 4ZWOA 4A6WA 2B3HA 2GG7A 1XGOA 3L24A 1R5GA 1WY2A 4ZWUA 4FO7A 4FLJA 3FM3A 4U70A 1CHMA 3PKDA 2GG3A 3MATA 5JFRA 3PKAA 1PV9A 2B3KA 2B3LA 1YW7A 1QZYA 1YW8A 1YW9A 2GU7A 4IPAA 1R58A 5JHUA 1BOAA 2MATA 1WL6A 2EVOA 4IF7A 5JI6A 1BN5A 2BWUA 4U1BA 2V6CA 5CIKA 2BHAA 1XNZA 2EVMA 3TAVA 2Q93A 1WLRA 4U75A 1WBQA 3PKBA 5FCFA 2HOWA 2GG9A 3CB6A 4IKSA 4S2RP 1B6AA 2BWVA 1WL9A 2BWTA 1XGMA 1KQ0A 3TB5A 4U71A 2ADUA 5D6EA 4IKUA 4HXXA 5CDVA 1QXWA 1KQ9A 1Y1NA 3RVAA 3BIQA 2GGBA 2DFIA 4B28A 1JAWA 2P98A 1YVMA 2GG8A 4U6EA 3IG4A 2BN7A 4PNCA 1C27A 2V3YA 2Q96A 2GTXA 3IU7A 4S01A 3PKEA 4A6VA 1C23A 2V3XA 3MR1A 4KM3A 4U6WA 1QXYA 2G6PA 3CTZA 5CDEA 5FCHA 1W2MA 3Q6DA 4FKCA 1C21A 2NQ7A 2GU4A 1XGSA 2GA2A 4JUQA 3RORA 5CE6A 3FMRA 3IU9A
chains in the Genus database with same CATH superfamily
4EGEA 4PV4A 5CNXA 1R5HA 4S00A 3D27A 4IECA 1N51A 4IKTA 2NQ6A 1C22A 2BHDA 3FMQA 1W7VA 2OAZA 2EA2A 4FLIA 4RZZA 5D6FA 2EA4A 2GG0A 3CB5A 4FLLA 3L7GA 1WN1A 2BWXA 2V3ZA 4Z7MA 2BWYA 1O0XA 2GU6A 4U69A 2GG2A 3MX6A 4QR8A 2P99A 2Q8KA 5CLSA 2BB7A 3IU8A 1WKMA 4U76A 1C24A 1A16A 2Q95A 4ZNGA 2IW2A 4RGZ1 1XGNA 2BWWA 5CDLA 1B59A 2ZSGA 4IKRA 2P9AA 2GZ5A 2OKNA 3BIPA 4U6ZA 2GU5A 4FLKA 2EVCA 2BH3A 1YJ3A 2BWSA 2BHCA 4ZWPA 3BITA 4IDYA 4FUKA 4IU6A 4S2TP 4U6JA 4FO8A 4RZYA 1KP0A 4U6CA 3S6BA 1M35A 1QXZA 2Q92A 3PKCA 4OOKA 2GG5A 5E5BA 2Q94A 2BHBA 1MATA 2GGCA 4MATA 4U73A 4R60A 4ZWOA 4A6WA 2B3HA 2GG7A 1XGOA 3L24A 1R5GA 1WY2A 4ZWUA 4FO7A 4FLJA 3FM3A 4U70A 1CHMA 3PKDA 2GG3A 3MATA 5JFRA 3PKAA 1PV9A 2B3KA 2B3LA 1YW7A 1QZYA 1YW8A 1YW9A 2GU7A 4IPAA 1R58A 5JHUA 1BOAA 2MATA 1WL6A 2EVOA 4IF7A 5JI6A 1BN5A 2BWUA 4U1BA 2V6CA 5CIKA 2BHAA 1XNZA 2EVMA 3TAVA 2Q93A 1WLRA 4U75A 1WBQA 3PKBA 5FCFA 2HOWA 2GG9A 3CB6A 4IKSA 4S2RP 1B6AA 2BWVA 1WL9A 2BWTA 1XGMA 1KQ0A 3TB5A 4U71A 2ADUA 5D6EA 4IKUA 4HXXA 5CDVA 1QXWA 1KQ9A 1Y1NA 3RVAA 3BIQA 2GGBA 2DFIA 4B28A 1JAWA 2P98A 1YVMA 2GG8A 4U6EA 3IG4A 2BN7A 4PNCA 1C27A 2V3YA 2Q96A 2GTXA 3IU7A 4S01A 3PKEA 4A6VA 1C23A 2V3XA 3MR1A 4KM3A 4U6WA 1QXYA 2G6PA 3CTZA 5CDEA 5FCHA 1W2MA 3Q6DA 4FKCA 1C21A 2NQ7A 2GU4A 1XGSA 2GA2A 4JUQA 3RORA 5CE6A 3FMRA 3IU9A
chains in the Genus database with same CATH topology
4EGEA 4PV4A 5CNXA 1R5HA 4S00A 3D27A 4IECA 1N51A 4IKTA 2NQ6A 1C22A 2BHDA 3FMQA 1W7VA 2OAZA 2EA2A 4FLIA 4RZZA 5D6FA 2EA4A 2GG0A 3CB5A 4FLLA 3L7GA 1WN1A 2BWXA 2V3ZA 4Z7MA 2BWYA 1O0XA 2GU6A 4U69A 2GG2A 3MX6A 4QR8A 2P99A 2Q8KA 5CLSA 2BB7A 3IU8A 1WKMA 4U76A 1C24A 1A16A 2Q95A 4ZNGA 2IW2A 4RGZ1 1XGNA 2BWWA 5CDLA 1B59A 2ZSGA 4IKRA 2P9AA 2GZ5A 2OKNA 3BIPA 4U6ZA 2GU5A 4FLKA 2EVCA 2BH3A 1YJ3A 2BWSA 2BHCA 4ZWPA 3BITA 4IDYA 4FUKA 4IU6A 4S2TP 4U6JA 4FO8A 4RZYA 1KP0A 4U6CA 3S6BA 1M35A 1QXZA 2Q92A 3PKCA 4OOKA 2GG5A 5E5BA 2Q94A 2BHBA 1MATA 2GGCA 4MATA 4U73A 4R60A 4ZWOA 4A6WA 2B3HA 2GG7A 1XGOA 3L24A 1R5GA 1WY2A 4ZWUA 4FO7A 4FLJA 3FM3A 4U70A 1CHMA 3PKDA 2GG3A 3MATA 5JFRA 3PKAA 1PV9A 2B3KA 2B3LA 1YW7A 1QZYA 1YW8A 1YW9A 2GU7A 4IPAA 1R58A 5JHUA 1BOAA 2MATA 1WL6A 2EVOA 4IF7A 5JI6A 1BN5A 2BWUA 4U1BA 2V6CA 5CIKA 2BHAA 1XNZA 2EVMA 3TAVA 2Q93A 1WLRA 4U75A 1WBQA 3PKBA 5FCFA 2HOWA 2GG9A 3CB6A 4IKSA 4S2RP 1B6AA 2BWVA 1WL9A 2BWTA 1XGMA 1KQ0A 3TB5A 4U71A 2ADUA 5D6EA 4IKUA 4HXXA 5CDVA 1QXWA 1KQ9A 1Y1NA 3RVAA 3BIQA 2GGBA 2DFIA 4B28A 1JAWA 2P98A 1YVMA 2GG8A 4U6EA 3IG4A 2BN7A 4PNCA 1C27A 2V3YA 2Q96A 2GTXA 3IU7A 4S01A 3PKEA 4A6VA 1C23A 2V3XA 3MR1A 4KM3A 4U6WA 1QXYA 2G6PA 3CTZA 5CDEA 5FCHA 1W2MA 3Q6DA 4FKCA 1C21A 2NQ7A 2GU4A 1XGSA 2GA2A 4JUQA 3RORA 5CE6A 3FMRA 3IU9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4EGE A;  4PV4 A;  5CNX A;  1R5H A;  4S00 A;  3D27 A;  4IEC A;  1N51 A;  4IKT A;  2NQ6 A;  1C22 A;  2BHD A;  3FMQ A;  1W7V A;  2OAZ A;  2EA2 A;  4FLI A;  4RZZ A;  5D6F A;  2EA4 A;  2GG0 A;  3CB5 A;  4FLL A;  3L7G A;  1WN1 A;  2BWX A;  2V3Z A;  4Z7M A;  2BWY A;  1O0X A;  2GU6 A;  4U69 A;  2GG2 A;  3MX6 A;  4QR8 A;  2P99 A;  2Q8K A;  5CLS A;  2BB7 A;  3IU8 A;  1WKM A;  4U76 A;  1C24 A;  1A16 A;  2Q95 A;  4ZNG A;  2IW2 A;  4RGZ 1;  1XGN A;  2BWW A;  5CDL A;  1B59 A;  2ZSG A;  4IKR A;  2P9A A;  2GZ5 A;  2OKN A;  3BIP A;  4U6Z A;  2GU5 A;  4FLK A;  2EVC A;  2BH3 A;  1YJ3 A;  2BWS A;  2BHC A;  4ZWP A;  3BIT A;  4IDY A;  4FUK A;  4IU6 A;  4S2T P;  4U6J A;  4FO8 A;  4RZY A;  1KP0 A;  4U6C A;  3S6B A;  1M35 A;  1QXZ A;  2Q92 A;  3PKC A;  4OOK A;  2GG5 A;  5E5B A;  2Q94 A;  2BHB A;  1MAT A;  2GGC A;  4MAT A;  4U73 A;  4R60 A;  4ZWO A;  4A6W A;  2B3H A;  2GG7 A;  1XGO A;  3L24 A;  1R5G A;  1WY2 A;  4ZWU A;  4FO7 A;  4FLJ A;  3FM3 A;  4U70 A;  1CHM A;  3PKD A;  2GG3 A;  3MAT A;  5JFR A;  3PKA A;  1PV9 A;  2B3K A;  2B3L A;  1YW7 A;  1QZY A;  1YW8 A;  1YW9 A;  2GU7 A;  4IPA A;  1R58 A;  5JHU A;  1BOA A;  2MAT A;  1WL6 A;  2EVO A;  4IF7 A;  5JI6 A;  1BN5 A;  2BWU A;  4U1B A;  2V6C A;  5CIK A;  2BHA A;  1XNZ A;  2EVM A;  3TAV A;  2Q93 A;  1WLR A;  4U75 A;  1WBQ A;  3PKB A;  5FCF A;  2HOW A;  2GG9 A;  3CB6 A;  4IKS A;  4S2R P;  1B6A A;  2BWV A;  1WL9 A;  2BWT A;  1XGM A;  1KQ0 A;  3TB5 A;  4U71 A;  2ADU A;  5D6E A;  4IKU A;  4HXX A;  5CDV A;  1QXW A;  1KQ9 A;  1Y1N A;  3RVA A;  3BIQ A;  2GGB A;  2DFI A;  4B28 A;  1JAW A;  2P98 A;  1YVM A;  2GG8 A;  4U6E A;  3IG4 A;  2BN7 A;  4PNC A;  1C27 A;  2V3Y A;  2Q96 A;  2GTX A;  3IU7 A;  4S01 A;  3PKE A;  4A6V A;  1C23 A;  2V3X A;  3MR1 A;  4KM3 A;  4U6W A;  1QXY A;  2G6P A;  3CTZ A;  5CDE A;  5FCH A;  1W2M A;  3Q6D A;  4FKC A;  1C21 A;  2NQ7 A;  2GU4 A;  1XGS A;  2GA2 A;  4JUQ A;  3ROR A;  5CE6 A;  3FMR A;  3IU9 A; 
#chains in the Genus database with same CATH topology
 4EGE A;  4PV4 A;  5CNX A;  1R5H A;  4S00 A;  3D27 A;  4IEC A;  1N51 A;  4IKT A;  2NQ6 A;  1C22 A;  2BHD A;  3FMQ A;  1W7V A;  2OAZ A;  2EA2 A;  4FLI A;  4RZZ A;  5D6F A;  2EA4 A;  2GG0 A;  3CB5 A;  4FLL A;  3L7G A;  1WN1 A;  2BWX A;  2V3Z A;  4Z7M A;  2BWY A;  1O0X A;  2GU6 A;  4U69 A;  2GG2 A;  3MX6 A;  4QR8 A;  2P99 A;  2Q8K A;  5CLS A;  2BB7 A;  3IU8 A;  1WKM A;  4U76 A;  1C24 A;  1A16 A;  2Q95 A;  4ZNG A;  2IW2 A;  4RGZ 1;  1XGN A;  2BWW A;  5CDL A;  1B59 A;  2ZSG A;  4IKR A;  2P9A A;  2GZ5 A;  2OKN A;  3BIP A;  4U6Z A;  2GU5 A;  4FLK A;  2EVC A;  2BH3 A;  1YJ3 A;  2BWS A;  2BHC A;  4ZWP A;  3BIT A;  4IDY A;  4FUK A;  4IU6 A;  4S2T P;  4U6J A;  4FO8 A;  4RZY A;  1KP0 A;  4U6C A;  3S6B A;  1M35 A;  1QXZ A;  2Q92 A;  3PKC A;  4OOK A;  2GG5 A;  5E5B A;  2Q94 A;  2BHB A;  1MAT A;  2GGC A;  4MAT A;  4U73 A;  4R60 A;  4ZWO A;  4A6W A;  2B3H A;  2GG7 A;  1XGO A;  3L24 A;  1R5G A;  1WY2 A;  4ZWU A;  4FO7 A;  4FLJ A;  3FM3 A;  4U70 A;  1CHM A;  3PKD A;  2GG3 A;  3MAT A;  5JFR A;  3PKA A;  1PV9 A;  2B3K A;  2B3L A;  1YW7 A;  1QZY A;  1YW8 A;  1YW9 A;  2GU7 A;  4IPA A;  1R58 A;  5JHU A;  1BOA A;  2MAT A;  1WL6 A;  2EVO A;  4IF7 A;  5JI6 A;  1BN5 A;  2BWU A;  4U1B A;  2V6C A;  5CIK A;  2BHA A;  1XNZ A;  2EVM A;  3TAV A;  2Q93 A;  1WLR A;  4U75 A;  1WBQ A;  3PKB A;  5FCF A;  2HOW A;  2GG9 A;  3CB6 A;  4IKS A;  4S2R P;  1B6A A;  2BWV A;  1WL9 A;  2BWT A;  1XGM A;  1KQ0 A;  3TB5 A;  4U71 A;  2ADU A;  5D6E A;  4IKU A;  4HXX A;  5CDV A;  1QXW A;  1KQ9 A;  1Y1N A;  3RVA A;  3BIQ A;  2GGB A;  2DFI A;  4B28 A;  1JAW A;  2P98 A;  1YVM A;  2GG8 A;  4U6E A;  3IG4 A;  2BN7 A;  4PNC A;  1C27 A;  2V3Y A;  2Q96 A;  2GTX A;  3IU7 A;  4S01 A;  3PKE A;  4A6V A;  1C23 A;  2V3X A;  3MR1 A;  4KM3 A;  4U6W A;  1QXY A;  2G6P A;  3CTZ A;  5CDE A;  5FCH A;  1W2M A;  3Q6D A;  4FKC A;  1C21 A;  2NQ7 A;  2GU4 A;  1XGS A;  2GA2 A;  4JUQ A;  3ROR A;  5CE6 A;  3FMR A;  3IU9 A; 
#chains in the Genus database with same CATH homology
 4EGE A;  4PV4 A;  5CNX A;  1R5H A;  4S00 A;  3D27 A;  4IEC A;  1N51 A;  4IKT A;  2NQ6 A;  1C22 A;  2BHD A;  3FMQ A;  1W7V A;  2OAZ A;  2EA2 A;  4FLI A;  4RZZ A;  5D6F A;  2EA4 A;  2GG0 A;  3CB5 A;  4FLL A;  3L7G A;  1WN1 A;  2BWX A;  2V3Z A;  4Z7M A;  2BWY A;  1O0X A;  2GU6 A;  4U69 A;  2GG2 A;  3MX6 A;  4QR8 A;  2P99 A;  2Q8K A;  5CLS A;  2BB7 A;  3IU8 A;  1WKM A;  4U76 A;  1C24 A;  1A16 A;  2Q95 A;  4ZNG A;  2IW2 A;  4RGZ 1;  1XGN A;  2BWW A;  5CDL A;  1B59 A;  2ZSG A;  4IKR A;  2P9A A;  2GZ5 A;  2OKN A;  3BIP A;  4U6Z A;  2GU5 A;  4FLK A;  2EVC A;  2BH3 A;  1YJ3 A;  2BWS A;  2BHC A;  4ZWP A;  3BIT A;  4IDY A;  4FUK A;  4IU6 A;  4S2T P;  4U6J A;  4FO8 A;  4RZY A;  1KP0 A;  4U6C A;  3S6B A;  1M35 A;  1QXZ A;  2Q92 A;  3PKC A;  4OOK A;  2GG5 A;  5E5B A;  2Q94 A;  2BHB A;  1MAT A;  2GGC A;  4MAT A;  4U73 A;  4R60 A;  4ZWO A;  4A6W A;  2B3H A;  2GG7 A;  1XGO A;  3L24 A;  1R5G A;  1WY2 A;  4ZWU A;  4FO7 A;  4FLJ A;  3FM3 A;  4U70 A;  1CHM A;  3PKD A;  2GG3 A;  3MAT A;  5JFR A;  3PKA A;  1PV9 A;  2B3K A;  2B3L A;  1YW7 A;  1QZY A;  1YW8 A;  1YW9 A;  2GU7 A;  4IPA A;  1R58 A;  5JHU A;  1BOA A;  2MAT A;  1WL6 A;  2EVO A;  4IF7 A;  5JI6 A;  1BN5 A;  2BWU A;  4U1B A;  2V6C A;  5CIK A;  2BHA A;  1XNZ A;  2EVM A;  3TAV A;  2Q93 A;  1WLR A;  4U75 A;  1WBQ A;  3PKB A;  5FCF A;  2HOW A;  2GG9 A;  3CB6 A;  4IKS A;  4S2R P;  1B6A A;  2BWV A;  1WL9 A;  2BWT A;  1XGM A;  1KQ0 A;  3TB5 A;  4U71 A;  2ADU A;  5D6E A;  4IKU A;  4HXX A;  5CDV A;  1QXW A;  1KQ9 A;  1Y1N A;  3RVA A;  3BIQ A;  2GGB A;  2DFI A;  4B28 A;  1JAW A;  2P98 A;  1YVM A;  2GG8 A;  4U6E A;  3IG4 A;  2BN7 A;  4PNC A;  1C27 A;  2V3Y A;  2Q96 A;  2GTX A;  3IU7 A;  4S01 A;  3PKE A;  4A6V A;  1C23 A;  2V3X A;  3MR1 A;  4KM3 A;  4U6W A;  1QXY A;  2G6P A;  3CTZ A;  5CDE A;  5FCH A;  1W2M A;  3Q6D A;  4FKC A;  1C21 A;  2NQ7 A;  2GU4 A;  1XGS A;  2GA2 A;  4JUQ A;  3ROR A;  5CE6 A;  3FMR A;  3IU9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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