1C22A

E. coli methionine aminopeptidase: trifluoromethionine complex
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords METHIONINE AMINOPEPTIDASE
publication title Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues.
pubmed doi rcsb
source organism Escherichia coli
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-07-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1c22A00
2Q92A 2GU5A 3PKCA 2Q8KA 2P98A 1BOAA 1QXZA 1R5HA 3MATA 2BHAA 1PV9A 2GG7A 4S00A 5CNXA 4FUKA 2NQ7A 4A6WA 1WLRA 4B28A 5FCHA 1YJ3A 2BWUA 4RGZ1 1W2MA 2B3LA 3TB5A 3D27A 2B3KA 4IF7A 4U6EA 3BITA 2BB7A 2BWSA 4U6CA 5CDLA 1QZYA 4U70A 5JI6A 1C22A 3BIPA 2ADUA 4OOKA 1M35A 3FM3A 3FMRA 1R5GA 3MX6A 4IECA 3S6BA 4ZWUA 4U73A 2BWVA 2V3ZA 1A16A 4IKSA 1Y1NA 2OAZA 3IU7A 2BHCA 3Q6DA 2V3YA 1KQ0A 1KQ9A 4A6VA 5CIKA 1O0XA 4EGEA 2P9AA 4FLKA 2GU7A 5CE6A 1R58A 4PNCA 1JAWA 1C24A 1B6AA 2BHDA 4ZNGA 4IU6A 1XGNA 1YW8A 4HXXA 2Q93A 4S01A 2ZSGA 2BN7A 4U6WA 4ZWOA 1QXYA 2OKNA 2HOWA 4IKUA 3PKBA 2IW2A 1XGOA 2BHBA 2GG2A 2GGBA 5CDVA 3PKEA 2GG9A 3BIQA 3PKDA 3IU9A 2GU6A 2Q96A 4QR8A 2EA4A 2GZ5A 2P99A 3PKAA 3IG4A 4U6ZA 4U76A 2EVCA 2GTXA 2Q94A 2GG0A 2BWYA 1WY2A 5CDEA 5E5BA 4FLJA 1KP0A 4FO8A 1XGSA 3MR1A 1WKMA 2DFIA 3CTZA 2GG8A 4R60A 1BN5A 1B59A 4U75A 4RZYA 4FKCA 1QXWA 1YVMA 2EVMA 4IKRA 1YW7A 1C21A 2V6CA 4S2RP 3RORA 2GG3A 4FLIA 2V3XA 4ZWPA 2G6PA 3L7GA 2GG5A 1N51A 2BWTA 2BWWA 4U71A 4MATA 2EVOA 3CB5A 2BWXA 1XNZA 5FCFA 3L24A 2GA2A 4RZZA 4KM3A 4IKTA 4U69A 4S2TP 2GU4A 1CHMA 3FMQA 4FO7A 1C27A 1YW9A 3TAVA 3RVAA 4IDYA 4PV4A 5D6FA 3CB6A 1XGMA 3IU8A 2EA2A 2GGCA 5JFRA 4U1BA 1C23A 5CLSA 1W7VA 1WBQA 1WL9A 4JUQA 4U6JA 2BH3A 4Z7MA 5D6EA 2B3HA 2MATA 2NQ6A 1WL6A 4FLLA 1MATA 2Q95A 1WN1A 5JHUA 4IPAA
chains in the Genus database with same CATH superfamily
2Q92A 2GU5A 3PKCA 2Q8KA 2P98A 1BOAA 1QXZA 1R5HA 3MATA 2BHAA 1PV9A 2GG7A 4S00A 5CNXA 4FUKA 2NQ7A 4A6WA 1WLRA 4B28A 5FCHA 1YJ3A 2BWUA 4RGZ1 1W2MA 2B3LA 3TB5A 3D27A 2B3KA 4IF7A 4U6EA 3BITA 2BB7A 2BWSA 4U6CA 5CDLA 1QZYA 4U70A 5JI6A 1C22A 3BIPA 2ADUA 4OOKA 1M35A 3FM3A 3FMRA 1R5GA 3MX6A 4IECA 3S6BA 4ZWUA 4U73A 2BWVA 2V3ZA 1A16A 4IKSA 1Y1NA 2OAZA 3IU7A 2BHCA 3Q6DA 2V3YA 1KQ0A 1KQ9A 4A6VA 5CIKA 1O0XA 4EGEA 2P9AA 4FLKA 2GU7A 5CE6A 1R58A 4PNCA 1JAWA 1C24A 1B6AA 2BHDA 4ZNGA 4IU6A 1XGNA 1YW8A 4HXXA 2Q93A 4S01A 2ZSGA 2BN7A 4U6WA 4ZWOA 1QXYA 2OKNA 2HOWA 4IKUA 3PKBA 2IW2A 1XGOA 2BHBA 2GG2A 2GGBA 5CDVA 3PKEA 2GG9A 3BIQA 3PKDA 3IU9A 2GU6A 2Q96A 4QR8A 2EA4A 2GZ5A 2P99A 3PKAA 3IG4A 4U6ZA 4U76A 2EVCA 2GTXA 2Q94A 2GG0A 2BWYA 1WY2A 5CDEA 5E5BA 4FLJA 1KP0A 4FO8A 1XGSA 3MR1A 1WKMA 2DFIA 3CTZA 2GG8A 4R60A 1BN5A 1B59A 4U75A 4RZYA 4FKCA 1QXWA 1YVMA 2EVMA 4IKRA 1YW7A 1C21A 2V6CA 4S2RP 3RORA 2GG3A 4FLIA 2V3XA 4ZWPA 2G6PA 3L7GA 2GG5A 1N51A 2BWTA 2BWWA 4U71A 4MATA 2EVOA 3CB5A 2BWXA 1XNZA 5FCFA 3L24A 2GA2A 4RZZA 4KM3A 4IKTA 4U69A 4S2TP 2GU4A 1CHMA 3FMQA 4FO7A 1C27A 1YW9A 3TAVA 3RVAA 4IDYA 4PV4A 5D6FA 3CB6A 1XGMA 3IU8A 2EA2A 2GGCA 5JFRA 4U1BA 1C23A 5CLSA 1W7VA 1WBQA 1WL9A 4JUQA 4U6JA 2BH3A 4Z7MA 5D6EA 2B3HA 2MATA 2NQ6A 1WL6A 4FLLA 1MATA 2Q95A 1WN1A 5JHUA 4IPAA
chains in the Genus database with same CATH topology
2Q92A 2GU5A 3PKCA 2Q8KA 2P98A 1BOAA 1QXZA 1R5HA 3MATA 2BHAA 1PV9A 2GG7A 4S00A 5CNXA 4FUKA 2NQ7A 4A6WA 1WLRA 4B28A 5FCHA 1YJ3A 2BWUA 4RGZ1 1W2MA 2B3LA 3TB5A 3D27A 2B3KA 4IF7A 4U6EA 3BITA 2BB7A 2BWSA 4U6CA 5CDLA 1QZYA 4U70A 5JI6A 1C22A 3BIPA 2ADUA 4OOKA 1M35A 3FM3A 3FMRA 1R5GA 3MX6A 4IECA 3S6BA 4ZWUA 4U73A 2BWVA 2V3ZA 1A16A 4IKSA 1Y1NA 2OAZA 3IU7A 2BHCA 3Q6DA 2V3YA 1KQ0A 1KQ9A 4A6VA 5CIKA 1O0XA 4EGEA 2P9AA 4FLKA 2GU7A 5CE6A 1R58A 4PNCA 1JAWA 1C24A 1B6AA 2BHDA 4ZNGA 4IU6A 1XGNA 1YW8A 4HXXA 2Q93A 4S01A 2ZSGA 2BN7A 4U6WA 4ZWOA 1QXYA 2OKNA 2HOWA 4IKUA 3PKBA 2IW2A 1XGOA 2BHBA 2GG2A 2GGBA 5CDVA 3PKEA 2GG9A 3BIQA 3PKDA 3IU9A 2GU6A 2Q96A 4QR8A 2EA4A 2GZ5A 2P99A 3PKAA 3IG4A 4U6ZA 4U76A 2EVCA 2GTXA 2Q94A 2GG0A 2BWYA 1WY2A 5CDEA 5E5BA 4FLJA 1KP0A 4FO8A 1XGSA 3MR1A 1WKMA 2DFIA 3CTZA 2GG8A 4R60A 1BN5A 1B59A 4U75A 4RZYA 4FKCA 1QXWA 1YVMA 2EVMA 4IKRA 1YW7A 1C21A 2V6CA 4S2RP 3RORA 2GG3A 4FLIA 2V3XA 4ZWPA 2G6PA 3L7GA 2GG5A 1N51A 2BWTA 2BWWA 4U71A 4MATA 2EVOA 3CB5A 2BWXA 1XNZA 5FCFA 3L24A 2GA2A 4RZZA 4KM3A 4IKTA 4U69A 4S2TP 2GU4A 1CHMA 3FMQA 4FO7A 1C27A 1YW9A 3TAVA 3RVAA 4IDYA 4PV4A 5D6FA 3CB6A 1XGMA 3IU8A 2EA2A 2GGCA 5JFRA 4U1BA 1C23A 5CLSA 1W7VA 1WBQA 1WL9A 4JUQA 4U6JA 2BH3A 4Z7MA 5D6EA 2B3HA 2MATA 2NQ6A 1WL6A 4FLLA 1MATA 2Q95A 1WN1A 5JHUA 4IPAA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2Q92 A;  2GU5 A;  3PKC A;  2Q8K A;  2P98 A;  1BOA A;  1QXZ A;  1R5H A;  3MAT A;  2BHA A;  1PV9 A;  2GG7 A;  4S00 A;  5CNX A;  4FUK A;  2NQ7 A;  4A6W A;  1WLR A;  4B28 A;  5FCH A;  1YJ3 A;  2BWU A;  4RGZ 1;  1W2M A;  2B3L A;  3TB5 A;  3D27 A;  2B3K A;  4IF7 A;  4U6E A;  3BIT A;  2BB7 A;  2BWS A;  4U6C A;  5CDL A;  1QZY A;  4U70 A;  5JI6 A;  1C22 A;  3BIP A;  2ADU A;  4OOK A;  1M35 A;  3FM3 A;  3FMR A;  1R5G A;  3MX6 A;  4IEC A;  3S6B A;  4ZWU A;  4U73 A;  2BWV A;  2V3Z A;  1A16 A;  4IKS A;  1Y1N A;  2OAZ A;  3IU7 A;  2BHC A;  3Q6D A;  2V3Y A;  1KQ0 A;  1KQ9 A;  4A6V A;  5CIK A;  1O0X A;  4EGE A;  2P9A A;  4FLK A;  2GU7 A;  5CE6 A;  1R58 A;  4PNC A;  1JAW A;  1C24 A;  1B6A A;  2BHD A;  4ZNG A;  4IU6 A;  1XGN A;  1YW8 A;  4HXX A;  2Q93 A;  4S01 A;  2ZSG A;  2BN7 A;  4U6W A;  4ZWO A;  1QXY A;  2OKN A;  2HOW A;  4IKU A;  3PKB A;  2IW2 A;  1XGO A;  2BHB A;  2GG2 A;  2GGB A;  5CDV A;  3PKE A;  2GG9 A;  3BIQ A;  3PKD A;  3IU9 A;  2GU6 A;  2Q96 A;  4QR8 A;  2EA4 A;  2GZ5 A;  2P99 A;  3PKA A;  3IG4 A;  4U6Z A;  4U76 A;  2EVC A;  2GTX A;  2Q94 A;  2GG0 A;  2BWY A;  1WY2 A;  5CDE A;  5E5B A;  4FLJ A;  1KP0 A;  4FO8 A;  1XGS A;  3MR1 A;  1WKM A;  2DFI A;  3CTZ A;  2GG8 A;  4R60 A;  1BN5 A;  1B59 A;  4U75 A;  4RZY A;  4FKC A;  1QXW A;  1YVM A;  2EVM A;  4IKR A;  1YW7 A;  1C21 A;  2V6C A;  4S2R P;  3ROR A;  2GG3 A;  4FLI A;  2V3X A;  4ZWP A;  2G6P A;  3L7G A;  2GG5 A;  1N51 A;  2BWT A;  2BWW A;  4U71 A;  4MAT A;  2EVO A;  3CB5 A;  2BWX A;  1XNZ A;  5FCF A;  3L24 A;  2GA2 A;  4RZZ A;  4KM3 A;  4IKT A;  4U69 A;  4S2T P;  2GU4 A;  1CHM A;  3FMQ A;  4FO7 A;  1C27 A;  1YW9 A;  3TAV A;  3RVA A;  4IDY A;  4PV4 A;  5D6F A;  3CB6 A;  1XGM A;  3IU8 A;  2EA2 A;  2GGC A;  5JFR A;  4U1B A;  1C23 A;  5CLS A;  1W7V A;  1WBQ A;  1WL9 A;  4JUQ A;  4U6J A;  2BH3 A;  4Z7M A;  5D6E A;  2B3H A;  2MAT A;  2NQ6 A;  1WL6 A;  4FLL A;  1MAT A;  2Q95 A;  1WN1 A;  5JHU A;  4IPA A; 
#chains in the Genus database with same CATH topology
 2Q92 A;  2GU5 A;  3PKC A;  2Q8K A;  2P98 A;  1BOA A;  1QXZ A;  1R5H A;  3MAT A;  2BHA A;  1PV9 A;  2GG7 A;  4S00 A;  5CNX A;  4FUK A;  2NQ7 A;  4A6W A;  1WLR A;  4B28 A;  5FCH A;  1YJ3 A;  2BWU A;  4RGZ 1;  1W2M A;  2B3L A;  3TB5 A;  3D27 A;  2B3K A;  4IF7 A;  4U6E A;  3BIT A;  2BB7 A;  2BWS A;  4U6C A;  5CDL A;  1QZY A;  4U70 A;  5JI6 A;  1C22 A;  3BIP A;  2ADU A;  4OOK A;  1M35 A;  3FM3 A;  3FMR A;  1R5G A;  3MX6 A;  4IEC A;  3S6B A;  4ZWU A;  4U73 A;  2BWV A;  2V3Z A;  1A16 A;  4IKS A;  1Y1N A;  2OAZ A;  3IU7 A;  2BHC A;  3Q6D A;  2V3Y A;  1KQ0 A;  1KQ9 A;  4A6V A;  5CIK A;  1O0X A;  4EGE A;  2P9A A;  4FLK A;  2GU7 A;  5CE6 A;  1R58 A;  4PNC A;  1JAW A;  1C24 A;  1B6A A;  2BHD A;  4ZNG A;  4IU6 A;  1XGN A;  1YW8 A;  4HXX A;  2Q93 A;  4S01 A;  2ZSG A;  2BN7 A;  4U6W A;  4ZWO A;  1QXY A;  2OKN A;  2HOW A;  4IKU A;  3PKB A;  2IW2 A;  1XGO A;  2BHB A;  2GG2 A;  2GGB A;  5CDV A;  3PKE A;  2GG9 A;  3BIQ A;  3PKD A;  3IU9 A;  2GU6 A;  2Q96 A;  4QR8 A;  2EA4 A;  2GZ5 A;  2P99 A;  3PKA A;  3IG4 A;  4U6Z A;  4U76 A;  2EVC A;  2GTX A;  2Q94 A;  2GG0 A;  2BWY A;  1WY2 A;  5CDE A;  5E5B A;  4FLJ A;  1KP0 A;  4FO8 A;  1XGS A;  3MR1 A;  1WKM A;  2DFI A;  3CTZ A;  2GG8 A;  4R60 A;  1BN5 A;  1B59 A;  4U75 A;  4RZY A;  4FKC A;  1QXW A;  1YVM A;  2EVM A;  4IKR A;  1YW7 A;  1C21 A;  2V6C A;  4S2R P;  3ROR A;  2GG3 A;  4FLI A;  2V3X A;  4ZWP A;  2G6P A;  3L7G A;  2GG5 A;  1N51 A;  2BWT A;  2BWW A;  4U71 A;  4MAT A;  2EVO A;  3CB5 A;  2BWX A;  1XNZ A;  5FCF A;  3L24 A;  2GA2 A;  4RZZ A;  4KM3 A;  4IKT A;  4U69 A;  4S2T P;  2GU4 A;  1CHM A;  3FMQ A;  4FO7 A;  1C27 A;  1YW9 A;  3TAV A;  3RVA A;  4IDY A;  4PV4 A;  5D6F A;  3CB6 A;  1XGM A;  3IU8 A;  2EA2 A;  2GGC A;  5JFR A;  4U1B A;  1C23 A;  5CLS A;  1W7V A;  1WBQ A;  1WL9 A;  4JUQ A;  4U6J A;  2BH3 A;  4Z7M A;  5D6E A;  2B3H A;  2MAT A;  2NQ6 A;  1WL6 A;  4FLL A;  1MAT A;  2Q95 A;  1WN1 A;  5JHU A;  4IPA A; 
#chains in the Genus database with same CATH homology
 2Q92 A;  2GU5 A;  3PKC A;  2Q8K A;  2P98 A;  1BOA A;  1QXZ A;  1R5H A;  3MAT A;  2BHA A;  1PV9 A;  2GG7 A;  4S00 A;  5CNX A;  4FUK A;  2NQ7 A;  4A6W A;  1WLR A;  4B28 A;  5FCH A;  1YJ3 A;  2BWU A;  4RGZ 1;  1W2M A;  2B3L A;  3TB5 A;  3D27 A;  2B3K A;  4IF7 A;  4U6E A;  3BIT A;  2BB7 A;  2BWS A;  4U6C A;  5CDL A;  1QZY A;  4U70 A;  5JI6 A;  1C22 A;  3BIP A;  2ADU A;  4OOK A;  1M35 A;  3FM3 A;  3FMR A;  1R5G A;  3MX6 A;  4IEC A;  3S6B A;  4ZWU A;  4U73 A;  2BWV A;  2V3Z A;  1A16 A;  4IKS A;  1Y1N A;  2OAZ A;  3IU7 A;  2BHC A;  3Q6D A;  2V3Y A;  1KQ0 A;  1KQ9 A;  4A6V A;  5CIK A;  1O0X A;  4EGE A;  2P9A A;  4FLK A;  2GU7 A;  5CE6 A;  1R58 A;  4PNC A;  1JAW A;  1C24 A;  1B6A A;  2BHD A;  4ZNG A;  4IU6 A;  1XGN A;  1YW8 A;  4HXX A;  2Q93 A;  4S01 A;  2ZSG A;  2BN7 A;  4U6W A;  4ZWO A;  1QXY A;  2OKN A;  2HOW A;  4IKU A;  3PKB A;  2IW2 A;  1XGO A;  2BHB A;  2GG2 A;  2GGB A;  5CDV A;  3PKE A;  2GG9 A;  3BIQ A;  3PKD A;  3IU9 A;  2GU6 A;  2Q96 A;  4QR8 A;  2EA4 A;  2GZ5 A;  2P99 A;  3PKA A;  3IG4 A;  4U6Z A;  4U76 A;  2EVC A;  2GTX A;  2Q94 A;  2GG0 A;  2BWY A;  1WY2 A;  5CDE A;  5E5B A;  4FLJ A;  1KP0 A;  4FO8 A;  1XGS A;  3MR1 A;  1WKM A;  2DFI A;  3CTZ A;  2GG8 A;  4R60 A;  1BN5 A;  1B59 A;  4U75 A;  4RZY A;  4FKC A;  1QXW A;  1YVM A;  2EVM A;  4IKR A;  1YW7 A;  1C21 A;  2V6C A;  4S2R P;  3ROR A;  2GG3 A;  4FLI A;  2V3X A;  4ZWP A;  2G6P A;  3L7G A;  2GG5 A;  1N51 A;  2BWT A;  2BWW A;  4U71 A;  4MAT A;  2EVO A;  3CB5 A;  2BWX A;  1XNZ A;  5FCF A;  3L24 A;  2GA2 A;  4RZZ A;  4KM3 A;  4IKT A;  4U69 A;  4S2T P;  2GU4 A;  1CHM A;  3FMQ A;  4FO7 A;  1C27 A;  1YW9 A;  3TAV A;  3RVA A;  4IDY A;  4PV4 A;  5D6F A;  3CB6 A;  1XGM A;  3IU8 A;  2EA2 A;  2GGC A;  5JFR A;  4U1B A;  1C23 A;  5CLS A;  1W7V A;  1WBQ A;  1WL9 A;  4JUQ A;  4U6J A;  2BH3 A;  4Z7M A;  5D6E A;  2B3H A;  2MAT A;  2NQ6 A;  1WL6 A;  4FLL A;  1MAT A;  2Q95 A;  1WN1 A;  5JHU A;  4IPA A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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