1YVMA

E. coli methionine aminopeptidase in complex with thiabendazole
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Metal Ions as Cofactors for the Binding of Inhibitors to Methionine Aminopeptidase: A Critical View of the Relevance of In Vitro Metalloenzyme Assays.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-02-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 1yvmA00
2GGCA 5D6EA 4JUQA 1WKMA 3MR1A 4U69A 2Q94A 2IW2A 1C23A 4FO8A 4A6WA 2BWYA 2OAZA 4PNCA 1CHMA 1XGNA 4OOKA 2GU4A 2NQ7A 2EVMA 3L7GA 3MX6A 2V6CA 3MATA 3PKBA 4ZWPA 2BHBA 2GA2A 5FCHA 4FLIA 4S00A 5CLSA 2GG9A 4FKCA 1JAWA 1WLRA 4IKUA 2Q96A 1R5GA 2BWXA 5CIKA 5CE6A 2GZ5A 3BIPA 1B6AA 2BWVA 4FLLA 1BN5A 4IECA 5D6FA 4U75A 3PKEA 4U71A 5CDVA 1Y1NA 3L24A 2BHCA 4U73A 3FM3A 5E5BA 3FMQA 3FMRA 2Q8KA 2HOWA 4IKSA 1WL6A 3PKCA 4QR8A 1BOAA 3RORA 2EA4A 2Q93A 2EVOA 4HXXA 3BITA 1R58A 3IU7A 4IPAA 2EA2A 2DFIA 2P9AA 4IDYA 2BB7A 4U6WA 1W7VA 3CB5A 3D27A 2GU5A 3PKAA 2V3ZA 3IU9A 2GTXA 2BWWA 2P98A 1YW8A 4FO7A 4EGEA 4RZYA 1A16A 4S2RP 2B3KA 4U76A 3IG4A 2GU7A 2GU6A 1PV9A 2ZSGA 1KP0A 2NQ6A 4S2TP 5CDLA 3PKDA 2B3HA 1M35A 2GG7A 1XGOA 2BN7A 4KM3A 3RVAA 2P99A 2Q95A 1C27A 4U6ZA 2BWTA 2V3YA 1YJ3A 2GG3A 1XNZA 4RGZ1 4FLKA 1N51A 3IU8A 1MATA 1XGSA 1KQ9A 3TAVA 3Q6DA 4U1BA 1R5HA 1WBQA 3BIQA 4U70A 4R60A 5JFRA 2V3XA 1WL9A 1B59A 2BHAA 4IF7A 2MATA 2Q92A 4IKTA 3TB5A 4A6VA 1YVMA 2BHDA 3CB6A 2OKNA 4B28A 2B3LA 4ZWUA 5CDEA 2BWUA 4IKRA 4MATA 5FCFA 5JI6A 2GG8A 1W2MA 1WN1A 4U6CA 5JHUA 1QZYA 4ZNGA 2BH3A 2BWSA 4U6EA 1C21A 1YW9A 2GG5A 2GG0A 4RZZA 1WY2A 2G6PA 4U6JA 4IU6A 5CNXA 3S6BA 1XGMA 1C24A 4Z7MA 1O0XA 4FLJA 2GGBA 1KQ0A 1QXWA 2GG2A 2ADUA 1QXYA 1C22A 1YW7A 4S01A 4PV4A 1QXZA 2EVCA 4FUKA 4ZWOA 3CTZA
chains in the Genus database with same CATH superfamily
2GGCA 5D6EA 4JUQA 1WKMA 3MR1A 4U69A 2Q94A 2IW2A 1C23A 4FO8A 4A6WA 2BWYA 2OAZA 4PNCA 1CHMA 1XGNA 4OOKA 2GU4A 2NQ7A 2EVMA 3L7GA 3MX6A 2V6CA 3MATA 3PKBA 4ZWPA 2BHBA 2GA2A 5FCHA 4FLIA 4S00A 5CLSA 2GG9A 4FKCA 1JAWA 1WLRA 4IKUA 2Q96A 1R5GA 2BWXA 5CIKA 5CE6A 2GZ5A 3BIPA 1B6AA 2BWVA 4FLLA 1BN5A 4IECA 5D6FA 4U75A 3PKEA 4U71A 5CDVA 1Y1NA 3L24A 2BHCA 4U73A 3FM3A 5E5BA 3FMQA 3FMRA 2Q8KA 2HOWA 4IKSA 1WL6A 3PKCA 4QR8A 1BOAA 3RORA 2EA4A 2Q93A 2EVOA 4HXXA 3BITA 1R58A 3IU7A 4IPAA 2EA2A 2DFIA 2P9AA 4IDYA 2BB7A 4U6WA 1W7VA 3CB5A 3D27A 2GU5A 3PKAA 2V3ZA 3IU9A 2GTXA 2BWWA 2P98A 1YW8A 4FO7A 4EGEA 4RZYA 1A16A 4S2RP 2B3KA 4U76A 3IG4A 2GU7A 2GU6A 1PV9A 2ZSGA 1KP0A 2NQ6A 4S2TP 5CDLA 3PKDA 2B3HA 1M35A 2GG7A 1XGOA 2BN7A 4KM3A 3RVAA 2P99A 2Q95A 1C27A 4U6ZA 2BWTA 2V3YA 1YJ3A 2GG3A 1XNZA 4RGZ1 4FLKA 1N51A 3IU8A 1MATA 1XGSA 1KQ9A 3TAVA 3Q6DA 4U1BA 1R5HA 1WBQA 3BIQA 4U70A 4R60A 5JFRA 2V3XA 1WL9A 1B59A 2BHAA 4IF7A 2MATA 2Q92A 4IKTA 3TB5A 4A6VA 1YVMA 2BHDA 3CB6A 2OKNA 4B28A 2B3LA 4ZWUA 5CDEA 2BWUA 4IKRA 4MATA 5FCFA 5JI6A 2GG8A 1W2MA 1WN1A 4U6CA 5JHUA 1QZYA 4ZNGA 2BH3A 2BWSA 4U6EA 1C21A 1YW9A 2GG5A 2GG0A 4RZZA 1WY2A 2G6PA 4U6JA 4IU6A 5CNXA 3S6BA 1XGMA 1C24A 4Z7MA 1O0XA 4FLJA 2GGBA 1KQ0A 1QXWA 2GG2A 2ADUA 1QXYA 1C22A 1YW7A 4S01A 4PV4A 1QXZA 2EVCA 4FUKA 4ZWOA 3CTZA
chains in the Genus database with same CATH topology
2GGCA 5D6EA 4JUQA 1WKMA 3MR1A 4U69A 2Q94A 2IW2A 1C23A 4FO8A 4A6WA 2BWYA 2OAZA 4PNCA 1CHMA 1XGNA 4OOKA 2GU4A 2NQ7A 2EVMA 3L7GA 3MX6A 2V6CA 3MATA 3PKBA 4ZWPA 2BHBA 2GA2A 5FCHA 4FLIA 4S00A 5CLSA 2GG9A 4FKCA 1JAWA 1WLRA 4IKUA 2Q96A 1R5GA 2BWXA 5CIKA 5CE6A 2GZ5A 3BIPA 1B6AA 2BWVA 4FLLA 1BN5A 4IECA 5D6FA 4U75A 3PKEA 4U71A 5CDVA 1Y1NA 3L24A 2BHCA 4U73A 3FM3A 5E5BA 3FMQA 3FMRA 2Q8KA 2HOWA 4IKSA 1WL6A 3PKCA 4QR8A 1BOAA 3RORA 2EA4A 2Q93A 2EVOA 4HXXA 3BITA 1R58A 3IU7A 4IPAA 2EA2A 2DFIA 2P9AA 4IDYA 2BB7A 4U6WA 1W7VA 3CB5A 3D27A 2GU5A 3PKAA 2V3ZA 3IU9A 2GTXA 2BWWA 2P98A 1YW8A 4FO7A 4EGEA 4RZYA 1A16A 4S2RP 2B3KA 4U76A 3IG4A 2GU7A 2GU6A 1PV9A 2ZSGA 1KP0A 2NQ6A 4S2TP 5CDLA 3PKDA 2B3HA 1M35A 2GG7A 1XGOA 2BN7A 4KM3A 3RVAA 2P99A 2Q95A 1C27A 4U6ZA 2BWTA 2V3YA 1YJ3A 2GG3A 1XNZA 4RGZ1 4FLKA 1N51A 3IU8A 1MATA 1XGSA 1KQ9A 3TAVA 3Q6DA 4U1BA 1R5HA 1WBQA 3BIQA 4U70A 4R60A 5JFRA 2V3XA 1WL9A 1B59A 2BHAA 4IF7A 2MATA 2Q92A 4IKTA 3TB5A 4A6VA 1YVMA 2BHDA 3CB6A 2OKNA 4B28A 2B3LA 4ZWUA 5CDEA 2BWUA 4IKRA 4MATA 5FCFA 5JI6A 2GG8A 1W2MA 1WN1A 4U6CA 5JHUA 1QZYA 4ZNGA 2BH3A 2BWSA 4U6EA 1C21A 1YW9A 2GG5A 2GG0A 4RZZA 1WY2A 2G6PA 4U6JA 4IU6A 5CNXA 3S6BA 1XGMA 1C24A 4Z7MA 1O0XA 4FLJA 2GGBA 1KQ0A 1QXWA 2GG2A 2ADUA 1QXYA 1C22A 1YW7A 4S01A 4PV4A 1QXZA 2EVCA 4FUKA 4ZWOA 3CTZA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2GGC A;  5D6E A;  4JUQ A;  1WKM A;  3MR1 A;  4U69 A;  2Q94 A;  2IW2 A;  1C23 A;  4FO8 A;  4A6W A;  2BWY A;  2OAZ A;  4PNC A;  1CHM A;  1XGN A;  4OOK A;  2GU4 A;  2NQ7 A;  2EVM A;  3L7G A;  3MX6 A;  2V6C A;  3MAT A;  3PKB A;  4ZWP A;  2BHB A;  2GA2 A;  5FCH A;  4FLI A;  4S00 A;  5CLS A;  2GG9 A;  4FKC A;  1JAW A;  1WLR A;  4IKU A;  2Q96 A;  1R5G A;  2BWX A;  5CIK A;  5CE6 A;  2GZ5 A;  3BIP A;  1B6A A;  2BWV A;  4FLL A;  1BN5 A;  4IEC A;  5D6F A;  4U75 A;  3PKE A;  4U71 A;  5CDV A;  1Y1N A;  3L24 A;  2BHC A;  4U73 A;  3FM3 A;  5E5B A;  3FMQ A;  3FMR A;  2Q8K A;  2HOW A;  4IKS A;  1WL6 A;  3PKC A;  4QR8 A;  1BOA A;  3ROR A;  2EA4 A;  2Q93 A;  2EVO A;  4HXX A;  3BIT A;  1R58 A;  3IU7 A;  4IPA A;  2EA2 A;  2DFI A;  2P9A A;  4IDY A;  2BB7 A;  4U6W A;  1W7V A;  3CB5 A;  3D27 A;  2GU5 A;  3PKA A;  2V3Z A;  3IU9 A;  2GTX A;  2BWW A;  2P98 A;  1YW8 A;  4FO7 A;  4EGE A;  4RZY A;  1A16 A;  4S2R P;  2B3K A;  4U76 A;  3IG4 A;  2GU7 A;  2GU6 A;  1PV9 A;  2ZSG A;  1KP0 A;  2NQ6 A;  4S2T P;  5CDL A;  3PKD A;  2B3H A;  1M35 A;  2GG7 A;  1XGO A;  2BN7 A;  4KM3 A;  3RVA A;  2P99 A;  2Q95 A;  1C27 A;  4U6Z A;  2BWT A;  2V3Y A;  1YJ3 A;  2GG3 A;  1XNZ A;  4RGZ 1;  4FLK A;  1N51 A;  3IU8 A;  1MAT A;  1XGS A;  1KQ9 A;  3TAV A;  3Q6D A;  4U1B A;  1R5H A;  1WBQ A;  3BIQ A;  4U70 A;  4R60 A;  5JFR A;  2V3X A;  1WL9 A;  1B59 A;  2BHA A;  4IF7 A;  2MAT A;  2Q92 A;  4IKT A;  3TB5 A;  4A6V A;  1YVM A;  2BHD A;  3CB6 A;  2OKN A;  4B28 A;  2B3L A;  4ZWU A;  5CDE A;  2BWU A;  4IKR A;  4MAT A;  5FCF A;  5JI6 A;  2GG8 A;  1W2M A;  1WN1 A;  4U6C A;  5JHU A;  1QZY A;  4ZNG A;  2BH3 A;  2BWS A;  4U6E A;  1C21 A;  1YW9 A;  2GG5 A;  2GG0 A;  4RZZ A;  1WY2 A;  2G6P A;  4U6J A;  4IU6 A;  5CNX A;  3S6B A;  1XGM A;  1C24 A;  4Z7M A;  1O0X A;  4FLJ A;  2GGB A;  1KQ0 A;  1QXW A;  2GG2 A;  2ADU A;  1QXY A;  1C22 A;  1YW7 A;  4S01 A;  4PV4 A;  1QXZ A;  2EVC A;  4FUK A;  4ZWO A;  3CTZ A; 
#chains in the Genus database with same CATH topology
 2GGC A;  5D6E A;  4JUQ A;  1WKM A;  3MR1 A;  4U69 A;  2Q94 A;  2IW2 A;  1C23 A;  4FO8 A;  4A6W A;  2BWY A;  2OAZ A;  4PNC A;  1CHM A;  1XGN A;  4OOK A;  2GU4 A;  2NQ7 A;  2EVM A;  3L7G A;  3MX6 A;  2V6C A;  3MAT A;  3PKB A;  4ZWP A;  2BHB A;  2GA2 A;  5FCH A;  4FLI A;  4S00 A;  5CLS A;  2GG9 A;  4FKC A;  1JAW A;  1WLR A;  4IKU A;  2Q96 A;  1R5G A;  2BWX A;  5CIK A;  5CE6 A;  2GZ5 A;  3BIP A;  1B6A A;  2BWV A;  4FLL A;  1BN5 A;  4IEC A;  5D6F A;  4U75 A;  3PKE A;  4U71 A;  5CDV A;  1Y1N A;  3L24 A;  2BHC A;  4U73 A;  3FM3 A;  5E5B A;  3FMQ A;  3FMR A;  2Q8K A;  2HOW A;  4IKS A;  1WL6 A;  3PKC A;  4QR8 A;  1BOA A;  3ROR A;  2EA4 A;  2Q93 A;  2EVO A;  4HXX A;  3BIT A;  1R58 A;  3IU7 A;  4IPA A;  2EA2 A;  2DFI A;  2P9A A;  4IDY A;  2BB7 A;  4U6W A;  1W7V A;  3CB5 A;  3D27 A;  2GU5 A;  3PKA A;  2V3Z A;  3IU9 A;  2GTX A;  2BWW A;  2P98 A;  1YW8 A;  4FO7 A;  4EGE A;  4RZY A;  1A16 A;  4S2R P;  2B3K A;  4U76 A;  3IG4 A;  2GU7 A;  2GU6 A;  1PV9 A;  2ZSG A;  1KP0 A;  2NQ6 A;  4S2T P;  5CDL A;  3PKD A;  2B3H A;  1M35 A;  2GG7 A;  1XGO A;  2BN7 A;  4KM3 A;  3RVA A;  2P99 A;  2Q95 A;  1C27 A;  4U6Z A;  2BWT A;  2V3Y A;  1YJ3 A;  2GG3 A;  1XNZ A;  4RGZ 1;  4FLK A;  1N51 A;  3IU8 A;  1MAT A;  1XGS A;  1KQ9 A;  3TAV A;  3Q6D A;  4U1B A;  1R5H A;  1WBQ A;  3BIQ A;  4U70 A;  4R60 A;  5JFR A;  2V3X A;  1WL9 A;  1B59 A;  2BHA A;  4IF7 A;  2MAT A;  2Q92 A;  4IKT A;  3TB5 A;  4A6V A;  1YVM A;  2BHD A;  3CB6 A;  2OKN A;  4B28 A;  2B3L A;  4ZWU A;  5CDE A;  2BWU A;  4IKR A;  4MAT A;  5FCF A;  5JI6 A;  2GG8 A;  1W2M A;  1WN1 A;  4U6C A;  5JHU A;  1QZY A;  4ZNG A;  2BH3 A;  2BWS A;  4U6E A;  1C21 A;  1YW9 A;  2GG5 A;  2GG0 A;  4RZZ A;  1WY2 A;  2G6P A;  4U6J A;  4IU6 A;  5CNX A;  3S6B A;  1XGM A;  1C24 A;  4Z7M A;  1O0X A;  4FLJ A;  2GGB A;  1KQ0 A;  1QXW A;  2GG2 A;  2ADU A;  1QXY A;  1C22 A;  1YW7 A;  4S01 A;  4PV4 A;  1QXZ A;  2EVC A;  4FUK A;  4ZWO A;  3CTZ A; 
#chains in the Genus database with same CATH homology
 2GGC A;  5D6E A;  4JUQ A;  1WKM A;  3MR1 A;  4U69 A;  2Q94 A;  2IW2 A;  1C23 A;  4FO8 A;  4A6W A;  2BWY A;  2OAZ A;  4PNC A;  1CHM A;  1XGN A;  4OOK A;  2GU4 A;  2NQ7 A;  2EVM A;  3L7G A;  3MX6 A;  2V6C A;  3MAT A;  3PKB A;  4ZWP A;  2BHB A;  2GA2 A;  5FCH A;  4FLI A;  4S00 A;  5CLS A;  2GG9 A;  4FKC A;  1JAW A;  1WLR A;  4IKU A;  2Q96 A;  1R5G A;  2BWX A;  5CIK A;  5CE6 A;  2GZ5 A;  3BIP A;  1B6A A;  2BWV A;  4FLL A;  1BN5 A;  4IEC A;  5D6F A;  4U75 A;  3PKE A;  4U71 A;  5CDV A;  1Y1N A;  3L24 A;  2BHC A;  4U73 A;  3FM3 A;  5E5B A;  3FMQ A;  3FMR A;  2Q8K A;  2HOW A;  4IKS A;  1WL6 A;  3PKC A;  4QR8 A;  1BOA A;  3ROR A;  2EA4 A;  2Q93 A;  2EVO A;  4HXX A;  3BIT A;  1R58 A;  3IU7 A;  4IPA A;  2EA2 A;  2DFI A;  2P9A A;  4IDY A;  2BB7 A;  4U6W A;  1W7V A;  3CB5 A;  3D27 A;  2GU5 A;  3PKA A;  2V3Z A;  3IU9 A;  2GTX A;  2BWW A;  2P98 A;  1YW8 A;  4FO7 A;  4EGE A;  4RZY A;  1A16 A;  4S2R P;  2B3K A;  4U76 A;  3IG4 A;  2GU7 A;  2GU6 A;  1PV9 A;  2ZSG A;  1KP0 A;  2NQ6 A;  4S2T P;  5CDL A;  3PKD A;  2B3H A;  1M35 A;  2GG7 A;  1XGO A;  2BN7 A;  4KM3 A;  3RVA A;  2P99 A;  2Q95 A;  1C27 A;  4U6Z A;  2BWT A;  2V3Y A;  1YJ3 A;  2GG3 A;  1XNZ A;  4RGZ 1;  4FLK A;  1N51 A;  3IU8 A;  1MAT A;  1XGS A;  1KQ9 A;  3TAV A;  3Q6D A;  4U1B A;  1R5H A;  1WBQ A;  3BIQ A;  4U70 A;  4R60 A;  5JFR A;  2V3X A;  1WL9 A;  1B59 A;  2BHA A;  4IF7 A;  2MAT A;  2Q92 A;  4IKT A;  3TB5 A;  4A6V A;  1YVM A;  2BHD A;  3CB6 A;  2OKN A;  4B28 A;  2B3L A;  4ZWU A;  5CDE A;  2BWU A;  4IKR A;  4MAT A;  5FCF A;  5JI6 A;  2GG8 A;  1W2M A;  1WN1 A;  4U6C A;  5JHU A;  1QZY A;  4ZNG A;  2BH3 A;  2BWS A;  4U6E A;  1C21 A;  1YW9 A;  2GG5 A;  2GG0 A;  4RZZ A;  1WY2 A;  2G6P A;  4U6J A;  4IU6 A;  5CNX A;  3S6B A;  1XGM A;  1C24 A;  4Z7M A;  1O0X A;  4FLJ A;  2GGB A;  1KQ0 A;  1QXW A;  2GG2 A;  2ADU A;  1QXY A;  1C22 A;  1YW7 A;  4S01 A;  4PV4 A;  1QXZ A;  2EVC A;  4FUK A;  4ZWO A;  3CTZ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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