2B3LA

Crystal structure of type i human methionine aminopeptidase in the apo form
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
305
structure length
305
Chain Sequence
PYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
total genus 98
structure length 305
sequence length 305
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2b3lA00
5D6EA 4U69A 2DFIA 4EGEA 3BIQA 3PKEA 4IKRA 4S00A 2ZSGA 3MX6A 1A16A 2OAZA 3RORA 2HOWA 1B6AA 3CTZA 1R58A 3IU7A 4Z7MA 2BWSA 2BB7A 4A6WA 3RVAA 4IECA 5D6FA 1XNZA 1C27A 2B3KA 3IU8A 3L24A 4U75A 4FLKA 2BWWA 3PKCA 2GTXA 4PV4A 2P99A 1XGSA 3BITA 4RZZA 2BWVA 1W2MA 1YW9A 1WN1A 1WKMA 2GG8A 1XGMA 3L7GA 4PNCA 2GU4A 3S6BA 5JI6A 1R5GA 4U1BA 4U6CA 3FMRA 2Q92A 5CDLA 4FO7A 4OOKA 2G6PA 5JHUA 4S2RP 4U71A 1BN5A 2GU6A 4U6EA 1C22A 3IU9A 2GG0A 2P9AA 1C24A 4S01A 4U73A 4FLIA 4IDYA 1QXWA 1QZYA 2V3ZA 1JAWA 4S2TP 4QR8A 4ZWUA 4IF7A 5CDEA 1MATA 1YW7A 3Q6DA 2Q94A 1C21A 5CE6A 5E5BA 2P98A 3CB6A 2BH3A 5CDVA 4HXXA 1Y1NA 2GG9A 3MATA 2IW2A 2GG3A 3PKDA 2GG7A 2MATA 1KQ0A 4IU6A 1KQ9A 1YVMA 2BHAA 2GU5A 2GG2A 4R60A 5FCFA 1CHMA 1PV9A 1WBQA 1R5HA 3CB5A 2GGBA 4FO8A 2BHBA 4U6JA 5CLSA 5CNXA 1WY2A 3FMQA 3IG4A 3TAVA 4IKTA 2BWXA 2NQ6A 1N51A 2EVCA 3MR1A 3FM3A 2Q96A 3TB5A 4FKCA 4U6ZA 1QXYA 4KM3A 2EA4A 2Q8KA 2GGCA 1QXZA 4U76A 5CIKA 2BHDA 4IKUA 1WL9A 2BN7A 4JUQA 2V3XA 4IPAA 2GZ5A 1KP0A 5JFRA 2BHCA 1BOAA 2V3YA 3BIPA 2EVMA 2B3LA 5FCHA 3PKBA 4FLJA 2V6CA 1YJ3A 4FLLA 3PKAA 2NQ7A 1B59A 1O0XA 1WLRA 2BWUA 4IKSA 3D27A 4ZNGA 4U6WA 4MATA 1XGOA 1YW8A 2EA2A 2BWYA 1C23A 4B28A 2ADUA 2B3HA 2GA2A 2Q93A 1W7VA 4FUKA 4U70A 2Q95A 4ZWPA 4RGZ1 2EVOA 4ZWOA 4RZYA 1M35A 2BWTA 1XGNA 2GG5A 2GU7A 4A6VA 1WL6A 2OKNA
chains in the Genus database with same CATH superfamily
5D6EA 4U69A 2DFIA 4EGEA 3BIQA 3PKEA 4IKRA 4S00A 2ZSGA 3MX6A 1A16A 2OAZA 3RORA 2HOWA 1B6AA 3CTZA 1R58A 3IU7A 4Z7MA 2BWSA 2BB7A 4A6WA 3RVAA 4IECA 5D6FA 1XNZA 1C27A 2B3KA 3IU8A 3L24A 4U75A 4FLKA 2BWWA 3PKCA 2GTXA 4PV4A 2P99A 1XGSA 3BITA 4RZZA 2BWVA 1W2MA 1YW9A 1WN1A 1WKMA 2GG8A 1XGMA 3L7GA 4PNCA 2GU4A 3S6BA 5JI6A 1R5GA 4U1BA 4U6CA 3FMRA 2Q92A 5CDLA 4FO7A 4OOKA 2G6PA 5JHUA 4S2RP 4U71A 1BN5A 2GU6A 4U6EA 1C22A 3IU9A 2GG0A 2P9AA 1C24A 4S01A 4U73A 4FLIA 4IDYA 1QXWA 1QZYA 2V3ZA 1JAWA 4S2TP 4QR8A 4ZWUA 4IF7A 5CDEA 1MATA 1YW7A 3Q6DA 2Q94A 1C21A 5CE6A 5E5BA 2P98A 3CB6A 2BH3A 5CDVA 4HXXA 1Y1NA 2GG9A 3MATA 2IW2A 2GG3A 3PKDA 2GG7A 2MATA 1KQ0A 4IU6A 1KQ9A 1YVMA 2BHAA 2GU5A 2GG2A 4R60A 5FCFA 1CHMA 1PV9A 1WBQA 1R5HA 3CB5A 2GGBA 4FO8A 2BHBA 4U6JA 5CLSA 5CNXA 1WY2A 3FMQA 3IG4A 3TAVA 4IKTA 2BWXA 2NQ6A 1N51A 2EVCA 3MR1A 3FM3A 2Q96A 3TB5A 4FKCA 4U6ZA 1QXYA 4KM3A 2EA4A 2Q8KA 2GGCA 1QXZA 4U76A 5CIKA 2BHDA 4IKUA 1WL9A 2BN7A 4JUQA 2V3XA 4IPAA 2GZ5A 1KP0A 5JFRA 2BHCA 1BOAA 2V3YA 3BIPA 2EVMA 2B3LA 5FCHA 3PKBA 4FLJA 2V6CA 1YJ3A 4FLLA 3PKAA 2NQ7A 1B59A 1O0XA 1WLRA 2BWUA 4IKSA 3D27A 4ZNGA 4U6WA 4MATA 1XGOA 1YW8A 2EA2A 2BWYA 1C23A 4B28A 2ADUA 2B3HA 2GA2A 2Q93A 1W7VA 4FUKA 4U70A 2Q95A 4ZWPA 4RGZ1 2EVOA 4ZWOA 4RZYA 1M35A 2BWTA 1XGNA 2GG5A 2GU7A 4A6VA 1WL6A 2OKNA
chains in the Genus database with same CATH topology
5D6EA 4U69A 2DFIA 4EGEA 3BIQA 3PKEA 4IKRA 4S00A 2ZSGA 3MX6A 1A16A 2OAZA 3RORA 2HOWA 1B6AA 3CTZA 1R58A 3IU7A 4Z7MA 2BWSA 2BB7A 4A6WA 3RVAA 4IECA 5D6FA 1XNZA 1C27A 2B3KA 3IU8A 3L24A 4U75A 4FLKA 2BWWA 3PKCA 2GTXA 4PV4A 2P99A 1XGSA 3BITA 4RZZA 2BWVA 1W2MA 1YW9A 1WN1A 1WKMA 2GG8A 1XGMA 3L7GA 4PNCA 2GU4A 3S6BA 5JI6A 1R5GA 4U1BA 4U6CA 3FMRA 2Q92A 5CDLA 4FO7A 4OOKA 2G6PA 5JHUA 4S2RP 4U71A 1BN5A 2GU6A 4U6EA 1C22A 3IU9A 2GG0A 2P9AA 1C24A 4S01A 4U73A 4FLIA 4IDYA 1QXWA 1QZYA 2V3ZA 1JAWA 4S2TP 4QR8A 4ZWUA 4IF7A 5CDEA 1MATA 1YW7A 3Q6DA 2Q94A 1C21A 5CE6A 5E5BA 2P98A 3CB6A 2BH3A 5CDVA 4HXXA 1Y1NA 2GG9A 3MATA 2IW2A 2GG3A 3PKDA 2GG7A 2MATA 1KQ0A 4IU6A 1KQ9A 1YVMA 2BHAA 2GU5A 2GG2A 4R60A 5FCFA 1CHMA 1PV9A 1WBQA 1R5HA 3CB5A 2GGBA 4FO8A 2BHBA 4U6JA 5CLSA 5CNXA 1WY2A 3FMQA 3IG4A 3TAVA 4IKTA 2BWXA 2NQ6A 1N51A 2EVCA 3MR1A 3FM3A 2Q96A 3TB5A 4FKCA 4U6ZA 1QXYA 4KM3A 2EA4A 2Q8KA 2GGCA 1QXZA 4U76A 5CIKA 2BHDA 4IKUA 1WL9A 2BN7A 4JUQA 2V3XA 4IPAA 2GZ5A 1KP0A 5JFRA 2BHCA 1BOAA 2V3YA 3BIPA 2EVMA 2B3LA 5FCHA 3PKBA 4FLJA 2V6CA 1YJ3A 4FLLA 3PKAA 2NQ7A 1B59A 1O0XA 1WLRA 2BWUA 4IKSA 3D27A 4ZNGA 4U6WA 4MATA 1XGOA 1YW8A 2EA2A 2BWYA 1C23A 4B28A 2ADUA 2B3HA 2GA2A 2Q93A 1W7VA 4FUKA 4U70A 2Q95A 4ZWPA 4RGZ1 2EVOA 4ZWOA 4RZYA 1M35A 2BWTA 1XGNA 2GG5A 2GU7A 4A6VA 1WL6A 2OKNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5D6E A;  4U69 A;  2DFI A;  4EGE A;  3BIQ A;  3PKE A;  4IKR A;  4S00 A;  2ZSG A;  3MX6 A;  1A16 A;  2OAZ A;  3ROR A;  2HOW A;  1B6A A;  3CTZ A;  1R58 A;  3IU7 A;  4Z7M A;  2BWS A;  2BB7 A;  4A6W A;  3RVA A;  4IEC A;  5D6F A;  1XNZ A;  1C27 A;  2B3K A;  3IU8 A;  3L24 A;  4U75 A;  4FLK A;  2BWW A;  3PKC A;  2GTX A;  4PV4 A;  2P99 A;  1XGS A;  3BIT A;  4RZZ A;  2BWV A;  1W2M A;  1YW9 A;  1WN1 A;  1WKM A;  2GG8 A;  1XGM A;  3L7G A;  4PNC A;  2GU4 A;  3S6B A;  5JI6 A;  1R5G A;  4U1B A;  4U6C A;  3FMR A;  2Q92 A;  5CDL A;  4FO7 A;  4OOK A;  2G6P A;  5JHU A;  4S2R P;  4U71 A;  1BN5 A;  2GU6 A;  4U6E A;  1C22 A;  3IU9 A;  2GG0 A;  2P9A A;  1C24 A;  4S01 A;  4U73 A;  4FLI A;  4IDY A;  1QXW A;  1QZY A;  2V3Z A;  1JAW A;  4S2T P;  4QR8 A;  4ZWU A;  4IF7 A;  5CDE A;  1MAT A;  1YW7 A;  3Q6D A;  2Q94 A;  1C21 A;  5CE6 A;  5E5B A;  2P98 A;  3CB6 A;  2BH3 A;  5CDV A;  4HXX A;  1Y1N A;  2GG9 A;  3MAT A;  2IW2 A;  2GG3 A;  3PKD A;  2GG7 A;  2MAT A;  1KQ0 A;  4IU6 A;  1KQ9 A;  1YVM A;  2BHA A;  2GU5 A;  2GG2 A;  4R60 A;  5FCF A;  1CHM A;  1PV9 A;  1WBQ A;  1R5H A;  3CB5 A;  2GGB A;  4FO8 A;  2BHB A;  4U6J A;  5CLS A;  5CNX A;  1WY2 A;  3FMQ A;  3IG4 A;  3TAV A;  4IKT A;  2BWX A;  2NQ6 A;  1N51 A;  2EVC A;  3MR1 A;  3FM3 A;  2Q96 A;  3TB5 A;  4FKC A;  4U6Z A;  1QXY A;  4KM3 A;  2EA4 A;  2Q8K A;  2GGC A;  1QXZ A;  4U76 A;  5CIK A;  2BHD A;  4IKU A;  1WL9 A;  2BN7 A;  4JUQ A;  2V3X A;  4IPA A;  2GZ5 A;  1KP0 A;  5JFR A;  2BHC A;  1BOA A;  2V3Y A;  3BIP A;  2EVM A;  2B3L A;  5FCH A;  3PKB A;  4FLJ A;  2V6C A;  1YJ3 A;  4FLL A;  3PKA A;  2NQ7 A;  1B59 A;  1O0X A;  1WLR A;  2BWU A;  4IKS A;  3D27 A;  4ZNG A;  4U6W A;  4MAT A;  1XGO A;  1YW8 A;  2EA2 A;  2BWY A;  1C23 A;  4B28 A;  2ADU A;  2B3H A;  2GA2 A;  2Q93 A;  1W7V A;  4FUK A;  4U70 A;  2Q95 A;  4ZWP A;  4RGZ 1;  2EVO A;  4ZWO A;  4RZY A;  1M35 A;  2BWT A;  1XGN A;  2GG5 A;  2GU7 A;  4A6V A;  1WL6 A;  2OKN A; 
#chains in the Genus database with same CATH topology
 5D6E A;  4U69 A;  2DFI A;  4EGE A;  3BIQ A;  3PKE A;  4IKR A;  4S00 A;  2ZSG A;  3MX6 A;  1A16 A;  2OAZ A;  3ROR A;  2HOW A;  1B6A A;  3CTZ A;  1R58 A;  3IU7 A;  4Z7M A;  2BWS A;  2BB7 A;  4A6W A;  3RVA A;  4IEC A;  5D6F A;  1XNZ A;  1C27 A;  2B3K A;  3IU8 A;  3L24 A;  4U75 A;  4FLK A;  2BWW A;  3PKC A;  2GTX A;  4PV4 A;  2P99 A;  1XGS A;  3BIT A;  4RZZ A;  2BWV A;  1W2M A;  1YW9 A;  1WN1 A;  1WKM A;  2GG8 A;  1XGM A;  3L7G A;  4PNC A;  2GU4 A;  3S6B A;  5JI6 A;  1R5G A;  4U1B A;  4U6C A;  3FMR A;  2Q92 A;  5CDL A;  4FO7 A;  4OOK A;  2G6P A;  5JHU A;  4S2R P;  4U71 A;  1BN5 A;  2GU6 A;  4U6E A;  1C22 A;  3IU9 A;  2GG0 A;  2P9A A;  1C24 A;  4S01 A;  4U73 A;  4FLI A;  4IDY A;  1QXW A;  1QZY A;  2V3Z A;  1JAW A;  4S2T P;  4QR8 A;  4ZWU A;  4IF7 A;  5CDE A;  1MAT A;  1YW7 A;  3Q6D A;  2Q94 A;  1C21 A;  5CE6 A;  5E5B A;  2P98 A;  3CB6 A;  2BH3 A;  5CDV A;  4HXX A;  1Y1N A;  2GG9 A;  3MAT A;  2IW2 A;  2GG3 A;  3PKD A;  2GG7 A;  2MAT A;  1KQ0 A;  4IU6 A;  1KQ9 A;  1YVM A;  2BHA A;  2GU5 A;  2GG2 A;  4R60 A;  5FCF A;  1CHM A;  1PV9 A;  1WBQ A;  1R5H A;  3CB5 A;  2GGB A;  4FO8 A;  2BHB A;  4U6J A;  5CLS A;  5CNX A;  1WY2 A;  3FMQ A;  3IG4 A;  3TAV A;  4IKT A;  2BWX A;  2NQ6 A;  1N51 A;  2EVC A;  3MR1 A;  3FM3 A;  2Q96 A;  3TB5 A;  4FKC A;  4U6Z A;  1QXY A;  4KM3 A;  2EA4 A;  2Q8K A;  2GGC A;  1QXZ A;  4U76 A;  5CIK A;  2BHD A;  4IKU A;  1WL9 A;  2BN7 A;  4JUQ A;  2V3X A;  4IPA A;  2GZ5 A;  1KP0 A;  5JFR A;  2BHC A;  1BOA A;  2V3Y A;  3BIP A;  2EVM A;  2B3L A;  5FCH A;  3PKB A;  4FLJ A;  2V6C A;  1YJ3 A;  4FLL A;  3PKA A;  2NQ7 A;  1B59 A;  1O0X A;  1WLR A;  2BWU A;  4IKS A;  3D27 A;  4ZNG A;  4U6W A;  4MAT A;  1XGO A;  1YW8 A;  2EA2 A;  2BWY A;  1C23 A;  4B28 A;  2ADU A;  2B3H A;  2GA2 A;  2Q93 A;  1W7V A;  4FUK A;  4U70 A;  2Q95 A;  4ZWP A;  4RGZ 1;  2EVO A;  4ZWO A;  4RZY A;  1M35 A;  2BWT A;  1XGN A;  2GG5 A;  2GU7 A;  4A6V A;  1WL6 A;  2OKN A; 
#chains in the Genus database with same CATH homology
 5D6E A;  4U69 A;  2DFI A;  4EGE A;  3BIQ A;  3PKE A;  4IKR A;  4S00 A;  2ZSG A;  3MX6 A;  1A16 A;  2OAZ A;  3ROR A;  2HOW A;  1B6A A;  3CTZ A;  1R58 A;  3IU7 A;  4Z7M A;  2BWS A;  2BB7 A;  4A6W A;  3RVA A;  4IEC A;  5D6F A;  1XNZ A;  1C27 A;  2B3K A;  3IU8 A;  3L24 A;  4U75 A;  4FLK A;  2BWW A;  3PKC A;  2GTX A;  4PV4 A;  2P99 A;  1XGS A;  3BIT A;  4RZZ A;  2BWV A;  1W2M A;  1YW9 A;  1WN1 A;  1WKM A;  2GG8 A;  1XGM A;  3L7G A;  4PNC A;  2GU4 A;  3S6B A;  5JI6 A;  1R5G A;  4U1B A;  4U6C A;  3FMR A;  2Q92 A;  5CDL A;  4FO7 A;  4OOK A;  2G6P A;  5JHU A;  4S2R P;  4U71 A;  1BN5 A;  2GU6 A;  4U6E A;  1C22 A;  3IU9 A;  2GG0 A;  2P9A A;  1C24 A;  4S01 A;  4U73 A;  4FLI A;  4IDY A;  1QXW A;  1QZY A;  2V3Z A;  1JAW A;  4S2T P;  4QR8 A;  4ZWU A;  4IF7 A;  5CDE A;  1MAT A;  1YW7 A;  3Q6D A;  2Q94 A;  1C21 A;  5CE6 A;  5E5B A;  2P98 A;  3CB6 A;  2BH3 A;  5CDV A;  4HXX A;  1Y1N A;  2GG9 A;  3MAT A;  2IW2 A;  2GG3 A;  3PKD A;  2GG7 A;  2MAT A;  1KQ0 A;  4IU6 A;  1KQ9 A;  1YVM A;  2BHA A;  2GU5 A;  2GG2 A;  4R60 A;  5FCF A;  1CHM A;  1PV9 A;  1WBQ A;  1R5H A;  3CB5 A;  2GGB A;  4FO8 A;  2BHB A;  4U6J A;  5CLS A;  5CNX A;  1WY2 A;  3FMQ A;  3IG4 A;  3TAV A;  4IKT A;  2BWX A;  2NQ6 A;  1N51 A;  2EVC A;  3MR1 A;  3FM3 A;  2Q96 A;  3TB5 A;  4FKC A;  4U6Z A;  1QXY A;  4KM3 A;  2EA4 A;  2Q8K A;  2GGC A;  1QXZ A;  4U76 A;  5CIK A;  2BHD A;  4IKU A;  1WL9 A;  2BN7 A;  4JUQ A;  2V3X A;  4IPA A;  2GZ5 A;  1KP0 A;  5JFR A;  2BHC A;  1BOA A;  2V3Y A;  3BIP A;  2EVM A;  2B3L A;  5FCH A;  3PKB A;  4FLJ A;  2V6C A;  1YJ3 A;  4FLL A;  3PKA A;  2NQ7 A;  1B59 A;  1O0X A;  1WLR A;  2BWU A;  4IKS A;  3D27 A;  4ZNG A;  4U6W A;  4MAT A;  1XGO A;  1YW8 A;  2EA2 A;  2BWY A;  1C23 A;  4B28 A;  2ADU A;  2B3H A;  2GA2 A;  2Q93 A;  1W7V A;  4FUK A;  4U70 A;  2Q95 A;  4ZWP A;  4RGZ 1;  2EVO A;  4ZWO A;  4RZY A;  1M35 A;  2BWT A;  1XGN A;  2GG5 A;  2GU7 A;  4A6V A;  1WL6 A;  2OKN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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