2BB7A

Mn form of e. coli methionine aminopeptidase in complex with a quinolinyl sulfonamide inhibitor
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
258
structure length
258
Chain Sequence
IKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 84
structure length 258
sequence length 258
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2bb7A00
1O0XA 2NQ7A 1W2MA 5D6EA 2DFIA 2BHDA 2EVCA 2NQ6A 3IG4A 1W7VA 1QXWA 2GG7A 4IKTA 2OAZA 4Z7MA 2BWSA 1WL9A 1XGMA 1KQ0A 2BWYA 2B3KA 2GU7A 5D6FA 2Q95A 2HOWA 1QXYA 2Q93A 5CLSA 4ZWPA 1R58A 1B6AA 2P99A 1N51A 2ZSGA 3PKEA 4IECA 3PKDA 2BWXA 3PKCA 2GU4A 2EA2A 2G6PA 3IU7A 2BHAA 1QXZA 4U1BA 2Q8KA 3RORA 2BWWA 2MATA 2OKNA 4FO8A 3FMRA 2Q92A 4U6CA 1WBQA 3FMQA 4B28A 2Q96A 1KP0A 4FLJA 1A16A 3FM3A 3RVAA 4U6WA 1WY2A 2GTXA 4IU6A 3TAVA 2EA4A 4U75A 1XNZA 3MX6A 3MATA 2BH3A 1QZYA 2BN7A 1YW9A 2BWVA 2V3YA 2GG2A 2BB7A 2P9AA 4PNCA 4RZYA 2Q94A 3PKAA 1YJ3A 1R5HA 2GG8A 5FCFA 4U71A 2GZ5A 4QR8A 1WL6A 2GG9A 4IKRA 4HXXA 1WLRA 1XGOA 5CDVA 1BOAA 1C27A 4R60A 3Q6DA 2IW2A 1B59A 4FO7A 4IDYA 1C21A 1C22A 2BHBA 2GA2A 2GGCA 4IKUA 4S00A 4ZWOA 2V6CA 4U70A 5CDLA 1CHMA 1BN5A 1M35A 1YW7A 4FLKA 2ADUA 4U69A 3L7GA 2GU6A 4U6ZA 2B3LA 2P98A 4A6VA 2BWUA 1KQ9A 4S2RP 4FUKA 5CNXA 1WKMA 3MR1A 1R5GA 2GU5A 1YW8A 5CE6A 2V3ZA 4PV4A 3CTZA 3BIPA 4IKSA 4RGZ1 5JHUA 4MATA 1MATA 2GG0A 1C23A 3BIQA 2V3XA 4IF7A 4S01A 4ZNGA 2GGBA 4A6WA 2GG3A 5JFRA 3TB5A 1C24A 3CB6A 5JI6A 2B3HA 4RZZA 4S2TP 1YVMA 4OOKA 4FLIA 1Y1NA 3CB5A 1XGNA 2BWTA 4U6EA 4U73A 4U6JA 4JUQA 3D27A 1WN1A 3IU9A 4KM3A 4FLLA 5E5BA 2EVMA 3PKBA 3BITA 4EGEA 2BHCA 3S6BA 5FCHA 1JAWA 4FKCA 5CDEA 2EVOA 4IPAA 4U76A 3IU8A 3L24A 5CIKA 4ZWUA 1PV9A 2GG5A 1XGSA
chains in the Genus database with same CATH superfamily
1O0XA 2NQ7A 1W2MA 5D6EA 2DFIA 2BHDA 2EVCA 2NQ6A 3IG4A 1W7VA 1QXWA 2GG7A 4IKTA 2OAZA 4Z7MA 2BWSA 1WL9A 1XGMA 1KQ0A 2BWYA 2B3KA 2GU7A 5D6FA 2Q95A 2HOWA 1QXYA 2Q93A 5CLSA 4ZWPA 1R58A 1B6AA 2P99A 1N51A 2ZSGA 3PKEA 4IECA 3PKDA 2BWXA 3PKCA 2GU4A 2EA2A 2G6PA 3IU7A 2BHAA 1QXZA 4U1BA 2Q8KA 3RORA 2BWWA 2MATA 2OKNA 4FO8A 3FMRA 2Q92A 4U6CA 1WBQA 3FMQA 4B28A 2Q96A 1KP0A 4FLJA 1A16A 3FM3A 3RVAA 4U6WA 1WY2A 2GTXA 4IU6A 3TAVA 2EA4A 4U75A 1XNZA 3MX6A 3MATA 2BH3A 1QZYA 2BN7A 1YW9A 2BWVA 2V3YA 2GG2A 2BB7A 2P9AA 4PNCA 4RZYA 2Q94A 3PKAA 1YJ3A 1R5HA 2GG8A 5FCFA 4U71A 2GZ5A 4QR8A 1WL6A 2GG9A 4IKRA 4HXXA 1WLRA 1XGOA 5CDVA 1BOAA 1C27A 4R60A 3Q6DA 2IW2A 1B59A 4FO7A 4IDYA 1C21A 1C22A 2BHBA 2GA2A 2GGCA 4IKUA 4S00A 4ZWOA 2V6CA 4U70A 5CDLA 1CHMA 1BN5A 1M35A 1YW7A 4FLKA 2ADUA 4U69A 3L7GA 2GU6A 4U6ZA 2B3LA 2P98A 4A6VA 2BWUA 1KQ9A 4S2RP 4FUKA 5CNXA 1WKMA 3MR1A 1R5GA 2GU5A 1YW8A 5CE6A 2V3ZA 4PV4A 3CTZA 3BIPA 4IKSA 4RGZ1 5JHUA 4MATA 1MATA 2GG0A 1C23A 3BIQA 2V3XA 4IF7A 4S01A 4ZNGA 2GGBA 4A6WA 2GG3A 5JFRA 3TB5A 1C24A 3CB6A 5JI6A 2B3HA 4RZZA 4S2TP 1YVMA 4OOKA 4FLIA 1Y1NA 3CB5A 1XGNA 2BWTA 4U6EA 4U73A 4U6JA 4JUQA 3D27A 1WN1A 3IU9A 4KM3A 4FLLA 5E5BA 2EVMA 3PKBA 3BITA 4EGEA 2BHCA 3S6BA 5FCHA 1JAWA 4FKCA 5CDEA 2EVOA 4IPAA 4U76A 3IU8A 3L24A 5CIKA 4ZWUA 1PV9A 2GG5A 1XGSA
chains in the Genus database with same CATH topology
1O0XA 2NQ7A 1W2MA 5D6EA 2DFIA 2BHDA 2EVCA 2NQ6A 3IG4A 1W7VA 1QXWA 2GG7A 4IKTA 2OAZA 4Z7MA 2BWSA 1WL9A 1XGMA 1KQ0A 2BWYA 2B3KA 2GU7A 5D6FA 2Q95A 2HOWA 1QXYA 2Q93A 5CLSA 4ZWPA 1R58A 1B6AA 2P99A 1N51A 2ZSGA 3PKEA 4IECA 3PKDA 2BWXA 3PKCA 2GU4A 2EA2A 2G6PA 3IU7A 2BHAA 1QXZA 4U1BA 2Q8KA 3RORA 2BWWA 2MATA 2OKNA 4FO8A 3FMRA 2Q92A 4U6CA 1WBQA 3FMQA 4B28A 2Q96A 1KP0A 4FLJA 1A16A 3FM3A 3RVAA 4U6WA 1WY2A 2GTXA 4IU6A 3TAVA 2EA4A 4U75A 1XNZA 3MX6A 3MATA 2BH3A 1QZYA 2BN7A 1YW9A 2BWVA 2V3YA 2GG2A 2BB7A 2P9AA 4PNCA 4RZYA 2Q94A 3PKAA 1YJ3A 1R5HA 2GG8A 5FCFA 4U71A 2GZ5A 4QR8A 1WL6A 2GG9A 4IKRA 4HXXA 1WLRA 1XGOA 5CDVA 1BOAA 1C27A 4R60A 3Q6DA 2IW2A 1B59A 4FO7A 4IDYA 1C21A 1C22A 2BHBA 2GA2A 2GGCA 4IKUA 4S00A 4ZWOA 2V6CA 4U70A 5CDLA 1CHMA 1BN5A 1M35A 1YW7A 4FLKA 2ADUA 4U69A 3L7GA 2GU6A 4U6ZA 2B3LA 2P98A 4A6VA 2BWUA 1KQ9A 4S2RP 4FUKA 5CNXA 1WKMA 3MR1A 1R5GA 2GU5A 1YW8A 5CE6A 2V3ZA 4PV4A 3CTZA 3BIPA 4IKSA 4RGZ1 5JHUA 4MATA 1MATA 2GG0A 1C23A 3BIQA 2V3XA 4IF7A 4S01A 4ZNGA 2GGBA 4A6WA 2GG3A 5JFRA 3TB5A 1C24A 3CB6A 5JI6A 2B3HA 4RZZA 4S2TP 1YVMA 4OOKA 4FLIA 1Y1NA 3CB5A 1XGNA 2BWTA 4U6EA 4U73A 4U6JA 4JUQA 3D27A 1WN1A 3IU9A 4KM3A 4FLLA 5E5BA 2EVMA 3PKBA 3BITA 4EGEA 2BHCA 3S6BA 5FCHA 1JAWA 4FKCA 5CDEA 2EVOA 4IPAA 4U76A 3IU8A 3L24A 5CIKA 4ZWUA 1PV9A 2GG5A 1XGSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O0X A;  2NQ7 A;  1W2M A;  5D6E A;  2DFI A;  2BHD A;  2EVC A;  2NQ6 A;  3IG4 A;  1W7V A;  1QXW A;  2GG7 A;  4IKT A;  2OAZ A;  4Z7M A;  2BWS A;  1WL9 A;  1XGM A;  1KQ0 A;  2BWY A;  2B3K A;  2GU7 A;  5D6F A;  2Q95 A;  2HOW A;  1QXY A;  2Q93 A;  5CLS A;  4ZWP A;  1R58 A;  1B6A A;  2P99 A;  1N51 A;  2ZSG A;  3PKE A;  4IEC A;  3PKD A;  2BWX A;  3PKC A;  2GU4 A;  2EA2 A;  2G6P A;  3IU7 A;  2BHA A;  1QXZ A;  4U1B A;  2Q8K A;  3ROR A;  2BWW A;  2MAT A;  2OKN A;  4FO8 A;  3FMR A;  2Q92 A;  4U6C A;  1WBQ A;  3FMQ A;  4B28 A;  2Q96 A;  1KP0 A;  4FLJ A;  1A16 A;  3FM3 A;  3RVA A;  4U6W A;  1WY2 A;  2GTX A;  4IU6 A;  3TAV A;  2EA4 A;  4U75 A;  1XNZ A;  3MX6 A;  3MAT A;  2BH3 A;  1QZY A;  2BN7 A;  1YW9 A;  2BWV A;  2V3Y A;  2GG2 A;  2BB7 A;  2P9A A;  4PNC A;  4RZY A;  2Q94 A;  3PKA A;  1YJ3 A;  1R5H A;  2GG8 A;  5FCF A;  4U71 A;  2GZ5 A;  4QR8 A;  1WL6 A;  2GG9 A;  4IKR A;  4HXX A;  1WLR A;  1XGO A;  5CDV A;  1BOA A;  1C27 A;  4R60 A;  3Q6D A;  2IW2 A;  1B59 A;  4FO7 A;  4IDY A;  1C21 A;  1C22 A;  2BHB A;  2GA2 A;  2GGC A;  4IKU A;  4S00 A;  4ZWO A;  2V6C A;  4U70 A;  5CDL A;  1CHM A;  1BN5 A;  1M35 A;  1YW7 A;  4FLK A;  2ADU A;  4U69 A;  3L7G A;  2GU6 A;  4U6Z A;  2B3L A;  2P98 A;  4A6V A;  2BWU A;  1KQ9 A;  4S2R P;  4FUK A;  5CNX A;  1WKM A;  3MR1 A;  1R5G A;  2GU5 A;  1YW8 A;  5CE6 A;  2V3Z A;  4PV4 A;  3CTZ A;  3BIP A;  4IKS A;  4RGZ 1;  5JHU A;  4MAT A;  1MAT A;  2GG0 A;  1C23 A;  3BIQ A;  2V3X A;  4IF7 A;  4S01 A;  4ZNG A;  2GGB A;  4A6W A;  2GG3 A;  5JFR A;  3TB5 A;  1C24 A;  3CB6 A;  5JI6 A;  2B3H A;  4RZZ A;  4S2T P;  1YVM A;  4OOK A;  4FLI A;  1Y1N A;  3CB5 A;  1XGN A;  2BWT A;  4U6E A;  4U73 A;  4U6J A;  4JUQ A;  3D27 A;  1WN1 A;  3IU9 A;  4KM3 A;  4FLL A;  5E5B A;  2EVM A;  3PKB A;  3BIT A;  4EGE A;  2BHC A;  3S6B A;  5FCH A;  1JAW A;  4FKC A;  5CDE A;  2EVO A;  4IPA A;  4U76 A;  3IU8 A;  3L24 A;  5CIK A;  4ZWU A;  1PV9 A;  2GG5 A;  1XGS A; 
#chains in the Genus database with same CATH topology
 1O0X A;  2NQ7 A;  1W2M A;  5D6E A;  2DFI A;  2BHD A;  2EVC A;  2NQ6 A;  3IG4 A;  1W7V A;  1QXW A;  2GG7 A;  4IKT A;  2OAZ A;  4Z7M A;  2BWS A;  1WL9 A;  1XGM A;  1KQ0 A;  2BWY A;  2B3K A;  2GU7 A;  5D6F A;  2Q95 A;  2HOW A;  1QXY A;  2Q93 A;  5CLS A;  4ZWP A;  1R58 A;  1B6A A;  2P99 A;  1N51 A;  2ZSG A;  3PKE A;  4IEC A;  3PKD A;  2BWX A;  3PKC A;  2GU4 A;  2EA2 A;  2G6P A;  3IU7 A;  2BHA A;  1QXZ A;  4U1B A;  2Q8K A;  3ROR A;  2BWW A;  2MAT A;  2OKN A;  4FO8 A;  3FMR A;  2Q92 A;  4U6C A;  1WBQ A;  3FMQ A;  4B28 A;  2Q96 A;  1KP0 A;  4FLJ A;  1A16 A;  3FM3 A;  3RVA A;  4U6W A;  1WY2 A;  2GTX A;  4IU6 A;  3TAV A;  2EA4 A;  4U75 A;  1XNZ A;  3MX6 A;  3MAT A;  2BH3 A;  1QZY A;  2BN7 A;  1YW9 A;  2BWV A;  2V3Y A;  2GG2 A;  2BB7 A;  2P9A A;  4PNC A;  4RZY A;  2Q94 A;  3PKA A;  1YJ3 A;  1R5H A;  2GG8 A;  5FCF A;  4U71 A;  2GZ5 A;  4QR8 A;  1WL6 A;  2GG9 A;  4IKR A;  4HXX A;  1WLR A;  1XGO A;  5CDV A;  1BOA A;  1C27 A;  4R60 A;  3Q6D A;  2IW2 A;  1B59 A;  4FO7 A;  4IDY A;  1C21 A;  1C22 A;  2BHB A;  2GA2 A;  2GGC A;  4IKU A;  4S00 A;  4ZWO A;  2V6C A;  4U70 A;  5CDL A;  1CHM A;  1BN5 A;  1M35 A;  1YW7 A;  4FLK A;  2ADU A;  4U69 A;  3L7G A;  2GU6 A;  4U6Z A;  2B3L A;  2P98 A;  4A6V A;  2BWU A;  1KQ9 A;  4S2R P;  4FUK A;  5CNX A;  1WKM A;  3MR1 A;  1R5G A;  2GU5 A;  1YW8 A;  5CE6 A;  2V3Z A;  4PV4 A;  3CTZ A;  3BIP A;  4IKS A;  4RGZ 1;  5JHU A;  4MAT A;  1MAT A;  2GG0 A;  1C23 A;  3BIQ A;  2V3X A;  4IF7 A;  4S01 A;  4ZNG A;  2GGB A;  4A6W A;  2GG3 A;  5JFR A;  3TB5 A;  1C24 A;  3CB6 A;  5JI6 A;  2B3H A;  4RZZ A;  4S2T P;  1YVM A;  4OOK A;  4FLI A;  1Y1N A;  3CB5 A;  1XGN A;  2BWT A;  4U6E A;  4U73 A;  4U6J A;  4JUQ A;  3D27 A;  1WN1 A;  3IU9 A;  4KM3 A;  4FLL A;  5E5B A;  2EVM A;  3PKB A;  3BIT A;  4EGE A;  2BHC A;  3S6B A;  5FCH A;  1JAW A;  4FKC A;  5CDE A;  2EVO A;  4IPA A;  4U76 A;  3IU8 A;  3L24 A;  5CIK A;  4ZWU A;  1PV9 A;  2GG5 A;  1XGS A; 
#chains in the Genus database with same CATH homology
 1O0X A;  2NQ7 A;  1W2M A;  5D6E A;  2DFI A;  2BHD A;  2EVC A;  2NQ6 A;  3IG4 A;  1W7V A;  1QXW A;  2GG7 A;  4IKT A;  2OAZ A;  4Z7M A;  2BWS A;  1WL9 A;  1XGM A;  1KQ0 A;  2BWY A;  2B3K A;  2GU7 A;  5D6F A;  2Q95 A;  2HOW A;  1QXY A;  2Q93 A;  5CLS A;  4ZWP A;  1R58 A;  1B6A A;  2P99 A;  1N51 A;  2ZSG A;  3PKE A;  4IEC A;  3PKD A;  2BWX A;  3PKC A;  2GU4 A;  2EA2 A;  2G6P A;  3IU7 A;  2BHA A;  1QXZ A;  4U1B A;  2Q8K A;  3ROR A;  2BWW A;  2MAT A;  2OKN A;  4FO8 A;  3FMR A;  2Q92 A;  4U6C A;  1WBQ A;  3FMQ A;  4B28 A;  2Q96 A;  1KP0 A;  4FLJ A;  1A16 A;  3FM3 A;  3RVA A;  4U6W A;  1WY2 A;  2GTX A;  4IU6 A;  3TAV A;  2EA4 A;  4U75 A;  1XNZ A;  3MX6 A;  3MAT A;  2BH3 A;  1QZY A;  2BN7 A;  1YW9 A;  2BWV A;  2V3Y A;  2GG2 A;  2BB7 A;  2P9A A;  4PNC A;  4RZY A;  2Q94 A;  3PKA A;  1YJ3 A;  1R5H A;  2GG8 A;  5FCF A;  4U71 A;  2GZ5 A;  4QR8 A;  1WL6 A;  2GG9 A;  4IKR A;  4HXX A;  1WLR A;  1XGO A;  5CDV A;  1BOA A;  1C27 A;  4R60 A;  3Q6D A;  2IW2 A;  1B59 A;  4FO7 A;  4IDY A;  1C21 A;  1C22 A;  2BHB A;  2GA2 A;  2GGC A;  4IKU A;  4S00 A;  4ZWO A;  2V6C A;  4U70 A;  5CDL A;  1CHM A;  1BN5 A;  1M35 A;  1YW7 A;  4FLK A;  2ADU A;  4U69 A;  3L7G A;  2GU6 A;  4U6Z A;  2B3L A;  2P98 A;  4A6V A;  2BWU A;  1KQ9 A;  4S2R P;  4FUK A;  5CNX A;  1WKM A;  3MR1 A;  1R5G A;  2GU5 A;  1YW8 A;  5CE6 A;  2V3Z A;  4PV4 A;  3CTZ A;  3BIP A;  4IKS A;  4RGZ 1;  5JHU A;  4MAT A;  1MAT A;  2GG0 A;  1C23 A;  3BIQ A;  2V3X A;  4IF7 A;  4S01 A;  4ZNG A;  2GGB A;  4A6W A;  2GG3 A;  5JFR A;  3TB5 A;  1C24 A;  3CB6 A;  5JI6 A;  2B3H A;  4RZZ A;  4S2T P;  1YVM A;  4OOK A;  4FLI A;  1Y1N A;  3CB5 A;  1XGN A;  2BWT A;  4U6E A;  4U73 A;  4U6J A;  4JUQ A;  3D27 A;  1WN1 A;  3IU9 A;  4KM3 A;  4FLL A;  5E5B A;  2EVM A;  3PKB A;  3BIT A;  4EGE A;  2BHC A;  3S6B A;  5FCH A;  1JAW A;  4FKC A;  5CDE A;  2EVO A;  4IPA A;  4U76 A;  3IU8 A;  3L24 A;  5CIK A;  4ZWU A;  1PV9 A;  2GG5 A;  1XGS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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