2BB7A

Mn form of e. coli methionine aminopeptidase in complex with a quinolinyl sulfonamide inhibitor
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
258
structure length
258
Chain Sequence
IKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli
publication title Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 84
structure length 258
sequence length 258
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2bb7A00
2OKNA 4S01A 3S6BA 3TAVA 2B3KA 5CDEA 2BHCA 1B6AA 4MATA 1WBQA 3PKDA 1KQ0A 2MATA 4U6WA 5JI6A 5JHUA 1BN5A 4IKTA 1O0XA 3FMQA 1XGMA 4R60A 4KM3A 4S2RP 1R5GA 3MX6A 2BHAA 5CE6A 1R5HA 1YVMA 2GTXA 4S2TP 4FO7A 2Q94A 3PKCA 4U6CA 4U71A 4U76A 2BWVA 4A6VA 3IG4A 4FUKA 4OOKA 1XGNA 1C27A 2BB7A 4U70A 1XGOA 2HOWA 2Q95A 5CDVA 2GG0A 1WLRA 3D27A 2EVCA 5D6FA 1B59A 4HXXA 2Q93A 1KQ9A 2BN7A 2BWYA 4IF7A 4A6WA 2V3ZA 1WL6A 2IW2A 2ZSGA 4IKSA 2NQ7A 3MATA 5FCHA 2BHDA 3Q6DA 4U6EA 2BWTA 3L24A 5E5BA 2P99A 2B3HA 4IECA 4ZWOA 1QZYA 1N51A 4IU6A 2BWWA 1W7VA 2BWUA 3L7GA 4B28A 3MR1A 5JFRA 5CLSA 3PKBA 2V3YA 2Q8KA 4RZYA 2GG8A 2GG2A 2P98A 1QXYA 5CNXA 2EA4A 2V6CA 4RZZA 4U69A 1YW7A 2GG5A 1PV9A 1QXWA 3FMRA 1C24A 4FLIA 4S00A 4U6ZA 4U75A 2BH3A 1A16A 4IDYA 4ZWPA 3RORA 2DFIA 2EVOA 2ADUA 3PKAA 3TB5A 5CDLA 2GGCA 3FM3A 3IU9A 2GU6A 4FKCA 2GG7A 1R58A 2Q92A 3IU8A 4IPAA 1XGSA 1CHMA 3IU7A 3CB6A 2BHBA 2B3LA 3RVAA 3BIQA 4U73A 1MATA 2GZ5A 2BWXA 2GA2A 4ZNGA 1WY2A 2GU4A 2NQ6A 1WL9A 4FLJA 1QXZA 2P9AA 5FCFA 1C21A 4IKUA 4PNCA 2G6PA 4JUQA 1YJ3A 2V3XA 4PV4A 3CB5A 4FO8A 1W2MA 4EGEA 2GGBA 1JAWA 2OAZA 4U1BA 2GG3A 2Q96A 1Y1NA 1M35A 1XNZA 2GU5A 1KP0A 3BIPA 2GG9A 4IKRA 1BOAA 1C22A 4FLKA 1YW8A 3BITA 2GU7A 2EVMA 5D6EA 5CIKA 4FLLA 4U6JA 4QR8A 3CTZA 4Z7MA 4RGZ1 4ZWUA 1C23A 1WKMA 1WN1A 2BWSA 2EA2A 1YW9A 3PKEA
chains in the Genus database with same CATH superfamily
2OKNA 4S01A 3S6BA 3TAVA 2B3KA 5CDEA 2BHCA 1B6AA 4MATA 1WBQA 3PKDA 1KQ0A 2MATA 4U6WA 5JI6A 5JHUA 1BN5A 4IKTA 1O0XA 3FMQA 1XGMA 4R60A 4KM3A 4S2RP 1R5GA 3MX6A 2BHAA 5CE6A 1R5HA 1YVMA 2GTXA 4S2TP 4FO7A 2Q94A 3PKCA 4U6CA 4U71A 4U76A 2BWVA 4A6VA 3IG4A 4FUKA 4OOKA 1XGNA 1C27A 2BB7A 4U70A 1XGOA 2HOWA 2Q95A 5CDVA 2GG0A 1WLRA 3D27A 2EVCA 5D6FA 1B59A 4HXXA 2Q93A 1KQ9A 2BN7A 2BWYA 4IF7A 4A6WA 2V3ZA 1WL6A 2IW2A 2ZSGA 4IKSA 2NQ7A 3MATA 5FCHA 2BHDA 3Q6DA 4U6EA 2BWTA 3L24A 5E5BA 2P99A 2B3HA 4IECA 4ZWOA 1QZYA 1N51A 4IU6A 2BWWA 1W7VA 2BWUA 3L7GA 4B28A 3MR1A 5JFRA 5CLSA 3PKBA 2V3YA 2Q8KA 4RZYA 2GG8A 2GG2A 2P98A 1QXYA 5CNXA 2EA4A 2V6CA 4RZZA 4U69A 1YW7A 2GG5A 1PV9A 1QXWA 3FMRA 1C24A 4FLIA 4S00A 4U6ZA 4U75A 2BH3A 1A16A 4IDYA 4ZWPA 3RORA 2DFIA 2EVOA 2ADUA 3PKAA 3TB5A 5CDLA 2GGCA 3FM3A 3IU9A 2GU6A 4FKCA 2GG7A 1R58A 2Q92A 3IU8A 4IPAA 1XGSA 1CHMA 3IU7A 3CB6A 2BHBA 2B3LA 3RVAA 3BIQA 4U73A 1MATA 2GZ5A 2BWXA 2GA2A 4ZNGA 1WY2A 2GU4A 2NQ6A 1WL9A 4FLJA 1QXZA 2P9AA 5FCFA 1C21A 4IKUA 4PNCA 2G6PA 4JUQA 1YJ3A 2V3XA 4PV4A 3CB5A 4FO8A 1W2MA 4EGEA 2GGBA 1JAWA 2OAZA 4U1BA 2GG3A 2Q96A 1Y1NA 1M35A 1XNZA 2GU5A 1KP0A 3BIPA 2GG9A 4IKRA 1BOAA 1C22A 4FLKA 1YW8A 3BITA 2GU7A 2EVMA 5D6EA 5CIKA 4FLLA 4U6JA 4QR8A 3CTZA 4Z7MA 4RGZ1 4ZWUA 1C23A 1WKMA 1WN1A 2BWSA 2EA2A 1YW9A 3PKEA
chains in the Genus database with same CATH topology
2OKNA 4S01A 3S6BA 3TAVA 2B3KA 5CDEA 2BHCA 1B6AA 4MATA 1WBQA 3PKDA 1KQ0A 2MATA 4U6WA 5JI6A 5JHUA 1BN5A 4IKTA 1O0XA 3FMQA 1XGMA 4R60A 4KM3A 4S2RP 1R5GA 3MX6A 2BHAA 5CE6A 1R5HA 1YVMA 2GTXA 4S2TP 4FO7A 2Q94A 3PKCA 4U6CA 4U71A 4U76A 2BWVA 4A6VA 3IG4A 4FUKA 4OOKA 1XGNA 1C27A 2BB7A 4U70A 1XGOA 2HOWA 2Q95A 5CDVA 2GG0A 1WLRA 3D27A 2EVCA 5D6FA 1B59A 4HXXA 2Q93A 1KQ9A 2BN7A 2BWYA 4IF7A 4A6WA 2V3ZA 1WL6A 2IW2A 2ZSGA 4IKSA 2NQ7A 3MATA 5FCHA 2BHDA 3Q6DA 4U6EA 2BWTA 3L24A 5E5BA 2P99A 2B3HA 4IECA 4ZWOA 1QZYA 1N51A 4IU6A 2BWWA 1W7VA 2BWUA 3L7GA 4B28A 3MR1A 5JFRA 5CLSA 3PKBA 2V3YA 2Q8KA 4RZYA 2GG8A 2GG2A 2P98A 1QXYA 5CNXA 2EA4A 2V6CA 4RZZA 4U69A 1YW7A 2GG5A 1PV9A 1QXWA 3FMRA 1C24A 4FLIA 4S00A 4U6ZA 4U75A 2BH3A 1A16A 4IDYA 4ZWPA 3RORA 2DFIA 2EVOA 2ADUA 3PKAA 3TB5A 5CDLA 2GGCA 3FM3A 3IU9A 2GU6A 4FKCA 2GG7A 1R58A 2Q92A 3IU8A 4IPAA 1XGSA 1CHMA 3IU7A 3CB6A 2BHBA 2B3LA 3RVAA 3BIQA 4U73A 1MATA 2GZ5A 2BWXA 2GA2A 4ZNGA 1WY2A 2GU4A 2NQ6A 1WL9A 4FLJA 1QXZA 2P9AA 5FCFA 1C21A 4IKUA 4PNCA 2G6PA 4JUQA 1YJ3A 2V3XA 4PV4A 3CB5A 4FO8A 1W2MA 4EGEA 2GGBA 1JAWA 2OAZA 4U1BA 2GG3A 2Q96A 1Y1NA 1M35A 1XNZA 2GU5A 1KP0A 3BIPA 2GG9A 4IKRA 1BOAA 1C22A 4FLKA 1YW8A 3BITA 2GU7A 2EVMA 5D6EA 5CIKA 4FLLA 4U6JA 4QR8A 3CTZA 4Z7MA 4RGZ1 4ZWUA 1C23A 1WKMA 1WN1A 2BWSA 2EA2A 1YW9A 3PKEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OKN A;  4S01 A;  3S6B A;  3TAV A;  2B3K A;  5CDE A;  2BHC A;  1B6A A;  4MAT A;  1WBQ A;  3PKD A;  1KQ0 A;  2MAT A;  4U6W A;  5JI6 A;  5JHU A;  1BN5 A;  4IKT A;  1O0X A;  3FMQ A;  1XGM A;  4R60 A;  4KM3 A;  4S2R P;  1R5G A;  3MX6 A;  2BHA A;  5CE6 A;  1R5H A;  1YVM A;  2GTX A;  4S2T P;  4FO7 A;  2Q94 A;  3PKC A;  4U6C A;  4U71 A;  4U76 A;  2BWV A;  4A6V A;  3IG4 A;  4FUK A;  4OOK A;  1XGN A;  1C27 A;  2BB7 A;  4U70 A;  1XGO A;  2HOW A;  2Q95 A;  5CDV A;  2GG0 A;  1WLR A;  3D27 A;  2EVC A;  5D6F A;  1B59 A;  4HXX A;  2Q93 A;  1KQ9 A;  2BN7 A;  2BWY A;  4IF7 A;  4A6W A;  2V3Z A;  1WL6 A;  2IW2 A;  2ZSG A;  4IKS A;  2NQ7 A;  3MAT A;  5FCH A;  2BHD A;  3Q6D A;  4U6E A;  2BWT A;  3L24 A;  5E5B A;  2P99 A;  2B3H A;  4IEC A;  4ZWO A;  1QZY A;  1N51 A;  4IU6 A;  2BWW A;  1W7V A;  2BWU A;  3L7G A;  4B28 A;  3MR1 A;  5JFR A;  5CLS A;  3PKB A;  2V3Y A;  2Q8K A;  4RZY A;  2GG8 A;  2GG2 A;  2P98 A;  1QXY A;  5CNX A;  2EA4 A;  2V6C A;  4RZZ A;  4U69 A;  1YW7 A;  2GG5 A;  1PV9 A;  1QXW A;  3FMR A;  1C24 A;  4FLI A;  4S00 A;  4U6Z A;  4U75 A;  2BH3 A;  1A16 A;  4IDY A;  4ZWP A;  3ROR A;  2DFI A;  2EVO A;  2ADU A;  3PKA A;  3TB5 A;  5CDL A;  2GGC A;  3FM3 A;  3IU9 A;  2GU6 A;  4FKC A;  2GG7 A;  1R58 A;  2Q92 A;  3IU8 A;  4IPA A;  1XGS A;  1CHM A;  3IU7 A;  3CB6 A;  2BHB A;  2B3L A;  3RVA A;  3BIQ A;  4U73 A;  1MAT A;  2GZ5 A;  2BWX A;  2GA2 A;  4ZNG A;  1WY2 A;  2GU4 A;  2NQ6 A;  1WL9 A;  4FLJ A;  1QXZ A;  2P9A A;  5FCF A;  1C21 A;  4IKU A;  4PNC A;  2G6P A;  4JUQ A;  1YJ3 A;  2V3X A;  4PV4 A;  3CB5 A;  4FO8 A;  1W2M A;  4EGE A;  2GGB A;  1JAW A;  2OAZ A;  4U1B A;  2GG3 A;  2Q96 A;  1Y1N A;  1M35 A;  1XNZ A;  2GU5 A;  1KP0 A;  3BIP A;  2GG9 A;  4IKR A;  1BOA A;  1C22 A;  4FLK A;  1YW8 A;  3BIT A;  2GU7 A;  2EVM A;  5D6E A;  5CIK A;  4FLL A;  4U6J A;  4QR8 A;  3CTZ A;  4Z7M A;  4RGZ 1;  4ZWU A;  1C23 A;  1WKM A;  1WN1 A;  2BWS A;  2EA2 A;  1YW9 A;  3PKE A; 
#chains in the Genus database with same CATH topology
 2OKN A;  4S01 A;  3S6B A;  3TAV A;  2B3K A;  5CDE A;  2BHC A;  1B6A A;  4MAT A;  1WBQ A;  3PKD A;  1KQ0 A;  2MAT A;  4U6W A;  5JI6 A;  5JHU A;  1BN5 A;  4IKT A;  1O0X A;  3FMQ A;  1XGM A;  4R60 A;  4KM3 A;  4S2R P;  1R5G A;  3MX6 A;  2BHA A;  5CE6 A;  1R5H A;  1YVM A;  2GTX A;  4S2T P;  4FO7 A;  2Q94 A;  3PKC A;  4U6C A;  4U71 A;  4U76 A;  2BWV A;  4A6V A;  3IG4 A;  4FUK A;  4OOK A;  1XGN A;  1C27 A;  2BB7 A;  4U70 A;  1XGO A;  2HOW A;  2Q95 A;  5CDV A;  2GG0 A;  1WLR A;  3D27 A;  2EVC A;  5D6F A;  1B59 A;  4HXX A;  2Q93 A;  1KQ9 A;  2BN7 A;  2BWY A;  4IF7 A;  4A6W A;  2V3Z A;  1WL6 A;  2IW2 A;  2ZSG A;  4IKS A;  2NQ7 A;  3MAT A;  5FCH A;  2BHD A;  3Q6D A;  4U6E A;  2BWT A;  3L24 A;  5E5B A;  2P99 A;  2B3H A;  4IEC A;  4ZWO A;  1QZY A;  1N51 A;  4IU6 A;  2BWW A;  1W7V A;  2BWU A;  3L7G A;  4B28 A;  3MR1 A;  5JFR A;  5CLS A;  3PKB A;  2V3Y A;  2Q8K A;  4RZY A;  2GG8 A;  2GG2 A;  2P98 A;  1QXY A;  5CNX A;  2EA4 A;  2V6C A;  4RZZ A;  4U69 A;  1YW7 A;  2GG5 A;  1PV9 A;  1QXW A;  3FMR A;  1C24 A;  4FLI A;  4S00 A;  4U6Z A;  4U75 A;  2BH3 A;  1A16 A;  4IDY A;  4ZWP A;  3ROR A;  2DFI A;  2EVO A;  2ADU A;  3PKA A;  3TB5 A;  5CDL A;  2GGC A;  3FM3 A;  3IU9 A;  2GU6 A;  4FKC A;  2GG7 A;  1R58 A;  2Q92 A;  3IU8 A;  4IPA A;  1XGS A;  1CHM A;  3IU7 A;  3CB6 A;  2BHB A;  2B3L A;  3RVA A;  3BIQ A;  4U73 A;  1MAT A;  2GZ5 A;  2BWX A;  2GA2 A;  4ZNG A;  1WY2 A;  2GU4 A;  2NQ6 A;  1WL9 A;  4FLJ A;  1QXZ A;  2P9A A;  5FCF A;  1C21 A;  4IKU A;  4PNC A;  2G6P A;  4JUQ A;  1YJ3 A;  2V3X A;  4PV4 A;  3CB5 A;  4FO8 A;  1W2M A;  4EGE A;  2GGB A;  1JAW A;  2OAZ A;  4U1B A;  2GG3 A;  2Q96 A;  1Y1N A;  1M35 A;  1XNZ A;  2GU5 A;  1KP0 A;  3BIP A;  2GG9 A;  4IKR A;  1BOA A;  1C22 A;  4FLK A;  1YW8 A;  3BIT A;  2GU7 A;  2EVM A;  5D6E A;  5CIK A;  4FLL A;  4U6J A;  4QR8 A;  3CTZ A;  4Z7M A;  4RGZ 1;  4ZWU A;  1C23 A;  1WKM A;  1WN1 A;  2BWS A;  2EA2 A;  1YW9 A;  3PKE A; 
#chains in the Genus database with same CATH homology
 2OKN A;  4S01 A;  3S6B A;  3TAV A;  2B3K A;  5CDE A;  2BHC A;  1B6A A;  4MAT A;  1WBQ A;  3PKD A;  1KQ0 A;  2MAT A;  4U6W A;  5JI6 A;  5JHU A;  1BN5 A;  4IKT A;  1O0X A;  3FMQ A;  1XGM A;  4R60 A;  4KM3 A;  4S2R P;  1R5G A;  3MX6 A;  2BHA A;  5CE6 A;  1R5H A;  1YVM A;  2GTX A;  4S2T P;  4FO7 A;  2Q94 A;  3PKC A;  4U6C A;  4U71 A;  4U76 A;  2BWV A;  4A6V A;  3IG4 A;  4FUK A;  4OOK A;  1XGN A;  1C27 A;  2BB7 A;  4U70 A;  1XGO A;  2HOW A;  2Q95 A;  5CDV A;  2GG0 A;  1WLR A;  3D27 A;  2EVC A;  5D6F A;  1B59 A;  4HXX A;  2Q93 A;  1KQ9 A;  2BN7 A;  2BWY A;  4IF7 A;  4A6W A;  2V3Z A;  1WL6 A;  2IW2 A;  2ZSG A;  4IKS A;  2NQ7 A;  3MAT A;  5FCH A;  2BHD A;  3Q6D A;  4U6E A;  2BWT A;  3L24 A;  5E5B A;  2P99 A;  2B3H A;  4IEC A;  4ZWO A;  1QZY A;  1N51 A;  4IU6 A;  2BWW A;  1W7V A;  2BWU A;  3L7G A;  4B28 A;  3MR1 A;  5JFR A;  5CLS A;  3PKB A;  2V3Y A;  2Q8K A;  4RZY A;  2GG8 A;  2GG2 A;  2P98 A;  1QXY A;  5CNX A;  2EA4 A;  2V6C A;  4RZZ A;  4U69 A;  1YW7 A;  2GG5 A;  1PV9 A;  1QXW A;  3FMR A;  1C24 A;  4FLI A;  4S00 A;  4U6Z A;  4U75 A;  2BH3 A;  1A16 A;  4IDY A;  4ZWP A;  3ROR A;  2DFI A;  2EVO A;  2ADU A;  3PKA A;  3TB5 A;  5CDL A;  2GGC A;  3FM3 A;  3IU9 A;  2GU6 A;  4FKC A;  2GG7 A;  1R58 A;  2Q92 A;  3IU8 A;  4IPA A;  1XGS A;  1CHM A;  3IU7 A;  3CB6 A;  2BHB A;  2B3L A;  3RVA A;  3BIQ A;  4U73 A;  1MAT A;  2GZ5 A;  2BWX A;  2GA2 A;  4ZNG A;  1WY2 A;  2GU4 A;  2NQ6 A;  1WL9 A;  4FLJ A;  1QXZ A;  2P9A A;  5FCF A;  1C21 A;  4IKU A;  4PNC A;  2G6P A;  4JUQ A;  1YJ3 A;  2V3X A;  4PV4 A;  3CB5 A;  4FO8 A;  1W2M A;  4EGE A;  2GGB A;  1JAW A;  2OAZ A;  4U1B A;  2GG3 A;  2Q96 A;  1Y1N A;  1M35 A;  1XNZ A;  2GU5 A;  1KP0 A;  3BIP A;  2GG9 A;  4IKR A;  1BOA A;  1C22 A;  4FLK A;  1YW8 A;  3BIT A;  2GU7 A;  2EVM A;  5D6E A;  5CIK A;  4FLL A;  4U6J A;  4QR8 A;  3CTZ A;  4Z7M A;  4RGZ 1;  4ZWU A;  1C23 A;  1WKM A;  1WN1 A;  2BWS A;  2EA2 A;  1YW9 A;  3PKE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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